IF 14.7 1区医学

Neuron Pub Date : 2024-10-09 Epub Date: 2024-09-13 DOI: 10.1016/j.neuron.2024.08.014

Yang Hu, Kevin K Park, Liu Yang, Xin Wei, Qiang Yang, Kin-Sang Cho, Peter Thielen, Ann-Hwee Lee, Romain Cartoni, Laurie H Glimcher, Dong Feng Chen, Zhigang He

引用次数: 0

Negative feedback control of hypothalamic feeding circuits by the taste of food. 食物味道对下丘脑摄食回路的负反馈控制。

IF 14.7 1区医学

Neuron Pub Date : 2024-10-09 Epub Date: 2024-08-16 DOI: 10.1016/j.neuron.2024.07.017

Tara J Aitken, Zhengya Liu, Truong Ly, Sarah Shehata, Nilla Sivakumar, Naymalis La Santa Medina, Lindsay A Gray, Jingkun Zhang, Naz Dundar, Chris Barnes, Zachary A Knight

{"title":"Negative feedback control of hypothalamic feeding circuits by the taste of food.","authors":"Tara J Aitken, Zhengya Liu, Truong Ly, Sarah Shehata, Nilla Sivakumar, Naymalis La Santa Medina, Lindsay A Gray, Jingkun Zhang, Naz Dundar, Chris Barnes, Zachary A Knight","doi":"10.1016/j.neuron.2024.07.017","DOIUrl":"10.1016/j.neuron.2024.07.017","url":null,"abstract":"The rewarding taste of food is critical for motivating animals to eat, but whether taste has a parallel function in promoting meal termination is not well understood. Here, we show that hunger-promoting agouti-related peptide (AgRP) neurons are rapidly inhibited during each bout of ingestion by a signal linked to the taste of food. Blocking these transient dips in activity via closed-loop optogenetic stimulation increases food intake by selectively delaying the onset of satiety. We show that upstream leptin-receptor-expressing neurons in the dorsomedial hypothalamus (DMHLepR) are tuned to respond to sweet or fatty tastes and exhibit time-locked activation during feeding that is the mirror image of downstream AgRP cells. These findings reveal an unexpected role for taste in the negative feedback control of ingestion. They also reveal a mechanism by which AgRP neurons, which are the primary cells that drive hunger, are able to influence the moment-by-moment dynamics of food consumption.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3354-3370.e5"},"PeriodicalIF":14.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy, aging, and age-related neurodegeneration. 自噬、衰老和与年龄相关的神经退行性变

IF 14.7 1区医学

Neuron Pub Date : 2024-10-08 DOI: 10.1016/j.neuron.2024.09.015

Jennifer E Palmer, Niall Wilson, Sung Min Son, Pawel Obrocki, Lidia Wrobel, Matea Rob, Michael Takla, Viktor I Korolchuk, David C Rubinsztein

{"title":"Autophagy, aging, and age-related neurodegeneration.","authors":"Jennifer E Palmer, Niall Wilson, Sung Min Son, Pawel Obrocki, Lidia Wrobel, Matea Rob, Michael Takla, Viktor I Korolchuk, David C Rubinsztein","doi":"10.1016/j.neuron.2024.09.015","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.09.015","url":null,"abstract":"Autophagy is a conserved mechanism that degrades damaged or superfluous cellular contents and enables nutrient recycling under starvation conditions. Many neurodegeneration-associated proteins are autophagy substrates, and autophagy upregulation ameliorates disease in many animal models of neurodegeneration by enhancing the clearance of toxic proteins, proinflammatory molecules, and dysfunctional organelles. Autophagy inhibition also induces neuronal and glial senescence, a phenomenon that occurs with increasing age in non-diseased brains as well as in response to neurodegeneration-associated stresses. However, aging and many neurodegeneration-associated proteins and mutations impair autophagy. This creates a potentially detrimental feedback loop whereby the accumulation of these disease-associated proteins impairs their autophagic clearance, facilitating their further accumulation and aggregation. Thus, understanding how autophagy interacts with aging, senescence, and neurodegenerative diseases in a temporal, cellular, and genetic context is important for the future clinical application of autophagy-modulating therapies in aging and neurodegeneration.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waste clearance shapes aging brain health. 清除废物塑造老年大脑健康

IF 14.7 1区医学

Neuron Pub Date : 2024-10-08 DOI: 10.1016/j.neuron.2024.09.017

Li-Feng Jiang-Xie, Antoine Drieu, Jonathan Kipnis

引用次数: 0

Regenerating enteric neurites navigate the adult intestine using a glial positioning system? 再生肠神经元利用神经胶质定位系统为成人肠道导航？

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.08.023

Candice Fung, Pieter Vanden Berghe

引用次数: 0

Protective lifelines: Tunneling nanotubes connect neurons and microglia. 保护生命线隧道纳米管连接神经元和小胶质细胞

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.07.027

Jonas J Neher, Mikael Simons

引用次数: 0

A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets. 单细胞图谱解构了小鼠创伤性脑损伤多种模型的异质性，并确定了新的细胞特异性靶标。

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 Epub Date: 2024-07-16 DOI: 10.1016/j.neuron.2024.06.021

Ruchira M Jha, Dhivyaa Rajasundaram, Chaim Sneiderman, Brent T Schlegel, Casey O'Brien, Zujian Xiong, Keri Janesko-Feldman, Ria Trivedi, Vincent Vagni, Benjamin E Zusman, Joshua S Catapano, Adam Eberle, Shashvat M Desai, Ashutosh P Jadhav, Sandra Mihaljevic, Margaux Miller, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shima Shahjouie, Itay Raphael, Aditya Kumar, Chia-Ling Phuah, Ethan A Winkler, Dennis W Simon, Patrick M Kochanek, Gary Kohanbash

{"title":"A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets.","authors":"Ruchira M Jha, Dhivyaa Rajasundaram, Chaim Sneiderman, Brent T Schlegel, Casey O'Brien, Zujian Xiong, Keri Janesko-Feldman, Ria Trivedi, Vincent Vagni, Benjamin E Zusman, Joshua S Catapano, Adam Eberle, Shashvat M Desai, Ashutosh P Jadhav, Sandra Mihaljevic, Margaux Miller, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shima Shahjouie, Itay Raphael, Aditya Kumar, Chia-Ling Phuah, Ethan A Winkler, Dennis W Simon, Patrick M Kochanek, Gary Kohanbash","doi":"10.1016/j.neuron.2024.06.021","DOIUrl":"10.1016/j.neuron.2024.06.021","url":null,"abstract":"Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies. Identifying final common pathways/molecular signatures that integrate this heterogeneity informs biomarker and therapeutic-target development. We present the first large-scale murine single-cell atlas of the transcriptomic response to TBI (334,376 cells) across clinically relevant models, sex, brain region, and time as a foundational step in molecularly deconstructing TBI heterogeneity. Results were unique to cell populations, injury models, sex, brain regions, and time, highlighting the importance of cell-level resolution. We identify cell-specific targets and previously unrecognized roles for microglial and ependymal subtypes. Ependymal-4 was a hub of neuroinflammatory signaling. A distinct microglial lineage shared features with disease-associated microglia at 24 h, with persistent gene-expression changes in microglia-4 even 6 months after contusional TBI, contrasting all other cell types that mostly returned to naive levels. Regional and sexual dimorphism were noted. CEREBRI, our searchable atlas (https://shiny.crc.pitt.edu/cerebri/), identifies previously unrecognized cell subtypes/molecular targets and is a leverageable platform for future efforts in TBI and other diseases with overlapping pathophysiology.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3069-3088.e4"},"PeriodicalIF":14.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezo1 ion channels are capable of conformational signaling. Piezo1 离子通道能够进行构象信号转导。

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 Epub Date: 2024-07-22 DOI: 10.1016/j.neuron.2024.06.024

Amanda H Lewis, Marie E Cronin, Jörg Grandl

{"title":"Piezo1 ion channels are capable of conformational signaling.","authors":"Amanda H Lewis, Marie E Cronin, Jörg Grandl","doi":"10.1016/j.neuron.2024.06.024","DOIUrl":"10.1016/j.neuron.2024.06.024","url":null,"abstract":"Piezo1 is a mechanically activated ion channel that senses forces with short latency and high sensitivity. Piezos undergo large conformational changes, induce far-reaching deformation onto the membrane, and modulate the function of two-pore potassium (K2P) channels. Taken together, this led us to hypothesize that Piezos may be able to signal their conformational state to other nearby proteins. Here, we use chemical control to acutely restrict Piezo1 conformational flexibility and show that Piezo1 conformational changes, but not ion permeation through them, are required for modulating the K2P channel K2P2.1 (TREK1). Super-resolution imaging and stochastic simulations further reveal that both channels do not co-localize, which implies that modulation is not mediated through direct binding interactions; however, at high Piezo1 densities, most TREK1 channels are within the predicted Piezo1 membrane footprint, suggesting that the footprint may underlie conformational signaling. We speculate that physiological roles originally attributed to Piezo1 ionotropic function could, alternatively, involve conformational signaling.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3161-3175.e5"},"PeriodicalIF":14.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cori Bargmann. 科里-巴尔格曼

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.09.008

Cori Bargmann

引用次数: 0

An abstract linguistic space for transmitting information from one mind to another. 一种抽象的语言空间，用于将信息从一个思维传递到另一个思维。

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.09.005

Greta Tuckute, Evelina Fedorenko

引用次数: 0

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