Neuron最新文献_第9页

A pontine center in descending pain control. 下行疼痛控制中的脑桥中枢。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 Epub Date: 2025-03-24 DOI: 10.1016/j.neuron.2025.02.028

Tianming Li, Wenjie Zhou, Jin Ke, Matthew Chen, Zhen Wang, Lauren Hayashi, Xiaojing Su, Wenbin Jia, Wenxi Huang, Chien-Sheng Wang, Kapsa Bengyella, Yang Yang, Rafael Hernandez, Yan Zhang, Xinglei Song, Tianle Xu, Tianwen Huang, Yuanyuan Liu

{"title":"A pontine center in descending pain control.","authors":"Tianming Li, Wenjie Zhou, Jin Ke, Matthew Chen, Zhen Wang, Lauren Hayashi, Xiaojing Su, Wenbin Jia, Wenxi Huang, Chien-Sheng Wang, Kapsa Bengyella, Yang Yang, Rafael Hernandez, Yan Zhang, Xinglei Song, Tianle Xu, Tianwen Huang, Yuanyuan Liu","doi":"10.1016/j.neuron.2025.02.028","DOIUrl":"10.1016/j.neuron.2025.02.028","url":null,"abstract":"Pain sensation changes according to expectation, context, and mood, illustrating how top-down circuits affect somatosensory processing. Here, we used an intersectional strategy to identify anatomical and molecular-spatial features of supraspinal descending neurons activated by distinct noxious stimulation. This approach captured known descending pain pathways as well as spinal projecting neurons that are anatomically mapped to Barrington's nucleus in the dorsal pontine tegmentum. We determined that this population of neurons expresses corticotropin-releasing hormone in Barrington's nucleus (BarCrh) and exhibits time-locked firing in response to noxious stimulation. Chemogenetic activation of BarCrh neurons attenuated nocifensive responses as well as tactile neuropathic pain, while silencing these neurons resulted in thermal hyperalgesia and mechanical allodynia. Mechanistically, we demonstrated that pain-related input from the ventrolateral periaqueductal gray recruits BarCrh neurons, reduces ascending nociceptive transmission, and preferentially activates spinal dynorphin neurons to mediate analgesia. Our data expose a pontine inhibitory descending pathway that powerfully controls nocifensive sensory input to the brain.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1789-1804.e7"},"PeriodicalIF":14.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pontospinal control of nociception via a negative feedback loop. 通过负反馈回路的桥脊控制伤害感觉。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 DOI: 10.1016/j.neuron.2025.05.007

Andrew D Vigotsky, Adrien Tassou, Grégory Scherrer

引用次数: 0

Stem cell sidekicks: ILC2s boost brain healing with a dash of Areg. 干细胞的伙伴：ILC2s通过少量Areg促进大脑愈合。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 DOI: 10.1016/j.neuron.2025.04.011

S Thomas Carmichael

引用次数: 0

Shedding light on the α-synuclein fibril fuzzy coat. 揭示α-突触核蛋白原纤维的绒毛被毛。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 DOI: 10.1016/j.neuron.2025.04.022

Joel C Watts

引用次数: 0

Key-value memory in the brain. 大脑中的关键值记忆。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 Epub Date: 2025-03-26 DOI: 10.1016/j.neuron.2025.02.029

Samuel J Gershman, Ila Fiete, Kazuki Irie

引用次数: 0

Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency. cxcr4相关原发性免疫缺陷的结构和精神运动缺陷的神经发育起源。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 DOI: 10.1016/j.neuron.2025.05.016

Giulia Demenego, Sara Mancinelli, Antonella Borreca, Rosalba Olga Proce, Vanessa Aragona, Matteo Miotto, Marco Cremonesi, Laura Zucchelli, Irene Corradini, Eugene Kim, Katarina Ilic, Edoardo Fraviga, Luca Pellegrino, Raffaele Badolato, Roberto Rusconi, Davide Pozzi, Marinos Kallikourdis, Diana Cash, Michela Matteoli, Simona Lodato

{"title":"Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency.","authors":"Giulia Demenego, Sara Mancinelli, Antonella Borreca, Rosalba Olga Proce, Vanessa Aragona, Matteo Miotto, Marco Cremonesi, Laura Zucchelli, Irene Corradini, Eugene Kim, Katarina Ilic, Edoardo Fraviga, Luca Pellegrino, Raffaele Badolato, Roberto Rusconi, Davide Pozzi, Marinos Kallikourdis, Diana Cash, Michela Matteoli, Simona Lodato","doi":"10.1016/j.neuron.2025.05.016","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.05.016","url":null,"abstract":"Inborn errors of immunity (IEI), as congenital chronic disorders, are often associated with neurobehavioral symptoms, traditionally considered secondary to patient burden. Their origin, however, has yet to be addressed. Here, we found that IEI-associated genes are expressed in neural lineages during human brain development, and in the absence of immunological challenges, IEI mutations directly impair neurodevelopmental trajectories, leading to psychomotor defects. Warts hypogammaglobulinemia immunodeficiency myelokathexis (WHIM) mice-bearing a mutation causing Cxcr4 hyperactivation-show developmental foliation defects of the cerebellum correlating with sensorimotor and affective dysfunctions, which recapitulate the alterations described in patients. WHIM cerebella single-cell profiling revealed major transcriptional deregulation in granule cell progenitors, whose aberrant proliferation and migration induce foliation and circuit defects. AMD3100 intracerebroventricular injection rescues both morphological and behavioral defects, demonstrating their brain-specific and Cxcr4-dependent origin. Collectively, our findings highlight the relevance of neurodevelopmental implications underlying psychomotor IEI manifestations, broadening our understanding of these conditions beyond immune dysfunctions.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neurobiology of overeating. 暴饮暴食的神经生物学。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 Epub Date: 2025-04-03 DOI: 10.1016/j.neuron.2025.03.010

Garret D Stuber, Valerie M Schwitzgebel, Christian Lüscher

{"title":"The neurobiology of overeating.","authors":"Garret D Stuber, Valerie M Schwitzgebel, Christian Lüscher","doi":"10.1016/j.neuron.2025.03.010","DOIUrl":"10.1016/j.neuron.2025.03.010","url":null,"abstract":"Food intake serves to maintain energy homeostasis; however, overeating can result in obesity, which is associated with serious health complications. In this review, we explore the intricate relationship between overeating, obesity, and the underlying neurobiological mechanisms. We review the homeostatic and hedonic feeding systems, highlighting the role of the hypothalamus and reward systems in controlling food intake and energy balance. Dysregulation in both these systems leads to overeating, as seen in genetic syndromes and environmental models affecting appetite regulation when consuming highly palatable food. The concept of \"food addiction\" is examined, drawing parallels to drug addiction. We discuss the cellular substrate for addiction-related behavior and current pharmacological obesity treatments-in particular, GLP-1 receptor agonists-showcasing synaptic plasticity in the context of overeating and palatable food exposure. A comprehensive model integrating insights from addiction research is proposed to guide effective interventions for maladaptive feeding behaviors. Ultimately, unraveling the neurobiological basis of overeating holds promise for addressing the pressing public health issue of obesity.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1680-1693"},"PeriodicalIF":14.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ILC2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke. ILC2指示神经干和祖细胞增强脑卒中后的神经修复。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 Epub Date: 2025-04-14 DOI: 10.1016/j.neuron.2025.03.014

Gaoyu Liu, Huachen Huang, Ying Wang, Yali Han, Jianye Wang, Mengxuan Shi, Pan Zhou, Chun Chen, Ying Yu, Qiang Liu, Jie Zhou

引用次数: 0

Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic pain. 感觉神经元中Piezo2感知的背根神经节血管运动触发阵发性神经性疼痛。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 Epub Date: 2025-03-27 DOI: 10.1016/j.neuron.2025.03.006

Wenrui Xie, Debora Denardin Lückemeyer, Katherine A Qualls, Arthur Silveira Prudente, Temugin Berta, Mingxia Gu, Judith A Strong, Xinzhong Dong, Jun-Ming Zhang

{"title":"Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic pain.","authors":"Wenrui Xie, Debora Denardin Lückemeyer, Katherine A Qualls, Arthur Silveira Prudente, Temugin Berta, Mingxia Gu, Judith A Strong, Xinzhong Dong, Jun-Ming Zhang","doi":"10.1016/j.neuron.2025.03.006","DOIUrl":"10.1016/j.neuron.2025.03.006","url":null,"abstract":"Spontaneous pain, characterized by episodic shooting or stabbing sensations, is a major complaint among neuropathic pain patients, yet its mechanisms remain poorly understood. Recent research indicates a connection between this pain condition and \"clustered firing,\" wherein adjacent sensory neurons fire simultaneously. This study presents evidence that the triggers of spontaneous pain and clustered firing are the dynamic movements of small blood vessels within the nerve-injured sensory ganglion, along with increased blood vessel density/angiogenesis and increased number of pericytes around blood vessels. Pharmacologically or mechanically evoked myogenic vascular responses increase both spontaneous pain and clustered firing in a mouse model of neuropathic pain. The mechanoreceptor Piezo2 in sensory neurons plays a critical role in detecting blood vessel movements. An anti-VEGF monoclonal antibody that inhibits angiogenesis effectively blocks spontaneous pain and clustered firing. These findings suggest targeting Piezo2, angiogenesis, or abnormal vascular dynamics as potential therapeutic strategies for neuropathic spontaneous pain.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1774-1788.e5"},"PeriodicalIF":14.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development. 不同物种和发育中阿片介导的海马和新皮层抑制的差异。

IF 14.7 1区医学

Neuron Pub Date : 2025-06-04 Epub Date: 2025-03-26 DOI: 10.1016/j.neuron.2025.03.005

Adam P Caccavano, Anna Vlachos, Nadiya McLean, Sarah Kimmel, June Hoan Kim, Geoffrey Vargish, Vivek Mahadevan, Lauren Hewitt, Anthony M Rossi, Ilona Spineux, Sherry Jingjing Wu, Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Yating Wang, Ramesh Chittajallu, Edra London, Xiaoqing Yuan, Steven Hunt, Daniel Abebe, Mark A G Eldridge, Alex C Cummins, Brendan E Hines, Anya Plotnikova, Arya Mohanty, Bruno B Averbeck, Kareem A Zaghloul, Jordane Dimidschstein, Gord Fishell, Kenneth A Pelkey, Chris J McBain

{"title":"Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development.","authors":"Adam P Caccavano, Anna Vlachos, Nadiya McLean, Sarah Kimmel, June Hoan Kim, Geoffrey Vargish, Vivek Mahadevan, Lauren Hewitt, Anthony M Rossi, Ilona Spineux, Sherry Jingjing Wu, Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Yating Wang, Ramesh Chittajallu, Edra London, Xiaoqing Yuan, Steven Hunt, Daniel Abebe, Mark A G Eldridge, Alex C Cummins, Brendan E Hines, Anya Plotnikova, Arya Mohanty, Bruno B Averbeck, Kareem A Zaghloul, Jordane Dimidschstein, Gord Fishell, Kenneth A Pelkey, Chris J McBain","doi":"10.1016/j.neuron.2025.03.005","DOIUrl":"10.1016/j.neuron.2025.03.005","url":null,"abstract":"Within adult rodent hippocampus (HPC), opioids suppress inhibitory parvalbumin-expressing interneurons (PV-INs), disinhibiting local microcircuits. However, it is unknown whether this disinhibitory motif is conserved across cortical regions, species, or development. We observed that PV-IN-mediated inhibition is robustly suppressed by opioids in HPC proper but not primary neocortex in mice and non-human primates, with spontaneous inhibitory tone in resected human tissue also following a consistent dichotomy. This hippocampal disinhibitory motif is established in early development when PV-INs and opioids regulate early population activity. Morphine pretreatment partially occludes this acute opioid-mediated suppression, with implications for the effects of opioids on hippocampal network activity important for learning and memory. Our findings demonstrate that PV-INs exhibit divergent opioid sensitivity across brain regions, which is remarkably conserved over evolution, and highlight the underappreciated role of opioids acting through immature PV-INs in shaping hippocampal development.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1805-1822.e7"},"PeriodicalIF":14.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0