IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-10 DOI: 10.1016/j.neuron.2025.02.013

Jessica A Higginbotham, Julian G Abt, Rachel H Teich, Joanna J Dearman, Tania Lintz, Jose A Morón

{"title":"Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males.","authors":"Jessica A Higginbotham, Julian G Abt, Rachel H Teich, Joanna J Dearman, Tania Lintz, Jose A Morón","doi":"10.1016/j.neuron.2025.02.013","DOIUrl":"10.1016/j.neuron.2025.02.013","url":null,"abstract":"Pain relief is the most frequently reported motivation for opioid misuse, but it remains unclear how pain alters reward pathway function contributing to maladaptive opioid use and whether these neuroadaptations occur in a sex-specific manner. Here, we show that persistent inflammatory pain leads to augmented fentanyl self-administration in male, not female, rats. Wireless in vivo fiber photometry recordings and chemogenetic manipulations indicate that pain-facilitated fentanyl use is mediated by enhanced ventral tegmental area dopamine (VTADA) neuron responses during self-administration. In females, ovariectomy enhances fentanyl self-administration, but the protective effects of ovarian hormones are not solely mediated by estradiol per se. Instead, pain and high estradiol states-naturally occurring in intact females or artificially produced in males-suppress fentanyl self-administration and associated VTADA activity through VTA estrogen receptor beta signaling. These findings highlight the importance of assessing hormonal factors in opioid misuse liability in the context of pain.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1413-1429.e5"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience influences the refinement of feature selectivity in the mouse primary visual thalamus. 经验影响小鼠初级视觉丘脑特征选择性的完善

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-19 DOI: 10.1016/j.neuron.2025.02.023

Takuma Sonoda, Céleste-Élise Stephany, Kaleb Kelley, Di Kang, Rui Wu, Meghna R Uzgare, Michela Fagiolini, Michael E Greenberg, Chinfei Chen

{"title":"Experience influences the refinement of feature selectivity in the mouse primary visual thalamus.","authors":"Takuma Sonoda, Céleste-Élise Stephany, Kaleb Kelley, Di Kang, Rui Wu, Meghna R Uzgare, Michela Fagiolini, Michael E Greenberg, Chinfei Chen","doi":"10.1016/j.neuron.2025.02.023","DOIUrl":"10.1016/j.neuron.2025.02.023","url":null,"abstract":"Neurons exhibit selectivity for specific features: a property essential for extracting and encoding relevant information in the environment. This feature selectivity is thought to be modifiable by experience at the level of the cortex. Here, we demonstrate that selective exposure to a feature during development can alter the population representation of that feature in the primary visual thalamus. This thalamic plasticity is not due to changes in corticothalamic inputs and is blocked in mutant mice that exhibit deficits in retinogeniculate refinement, suggesting that plasticity is a direct result of changes in feedforward connectivity. Notably, experience-dependent changes in thalamic feature selectivity also occur in adult animals, although these changes are transient, unlike in juvenile animals, where they are long lasting. These results reveal an unexpected degree of plasticity in the visual thalamus and show that salient environmental features can be encoded in thalamic circuits during a discrete developmental window.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1352-1362.e4"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking through anhedonia: How ketamine reignites the drive for rewards. 突破快感缺乏症：氯胺酮如何重新点燃对奖励的渴望。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.03.025

Colleen A McClung

引用次数: 0

Shaping sight: Novel thalamic plasticity channels dLGN feature preference during visual critical period. 视觉塑造：视觉关键期新丘脑可塑性通道与lgn特征偏好。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.001

Chuying Zhou, Xiang Gao, Liming Tan

引用次数: 0

TMEM63B functions as a mammalian hyperosmolar sensor for thirst. TMEM63B作为哺乳动物口渴的高渗传感器。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-18 DOI: 10.1016/j.neuron.2025.02.012

Wenjie Zou, Siqi Deng, Xingyu Chen, Jiamin Ruan, Huize Wang, Wuqiang Zhan, Jingxin Wang, Zhiyong Liu, Zhiqiang Yan

引用次数: 0

PI3P: Rising to the (DPR) challenge in C9-ALS/FTD. PI3P：应对C9-ALS/FTD的（DPR）挑战。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.007

Janani Parameswaran, Zachary T McEachin

引用次数: 0

The predictive nature of spontaneous brain activity across scales and species. 跨尺度和跨物种的自发脑活动的预测性。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-17 DOI: 10.1016/j.neuron.2025.02.009

Anastasia Dimakou, Giovanni Pezzulo, Andrea Zangrossi, Maurizio Corbetta

{"title":"The predictive nature of spontaneous brain activity across scales and species.","authors":"Anastasia Dimakou, Giovanni Pezzulo, Andrea Zangrossi, Maurizio Corbetta","doi":"10.1016/j.neuron.2025.02.009","DOIUrl":"10.1016/j.neuron.2025.02.009","url":null,"abstract":"Emerging research suggests the brain operates as a \"prediction machine,\" continuously anticipating sensory, motor, and cognitive outcomes. Central to this capability is the brain's spontaneous activity-ongoing internal processes independent of external stimuli. Neuroimaging and computational studies support that this activity is integral to maintaining and refining mental models of our environment, body, and behaviors, akin to generative models in computation. During rest, spontaneous activity expands the variability of potential representations, enhancing the accuracy and adaptability of these models. When performing tasks, internal models direct brain regions to anticipate sensory and motor states, optimizing performance. This review synthesizes evidence from various species, from C. elegans to humans, highlighting three key aspects of spontaneous brain activity's role in prediction: the similarity between spontaneous and task-related activity, the encoding of behavioral and interoceptive priors, and the high metabolic cost of this activity, underscoring prediction as a fundamental function of brains across species.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1310-1332"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human pain neuroscience and the next generation of pain therapeutics. 人类疼痛神经科学和下一代疼痛疗法。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.005

Bryan A Copits, Michele Curatolo, Patrick M Dougherty, Robert W Gereau, Wenqin Luo, Maryann Martone, Hakan Olausson, Theodore J Price, William Renthal, Clifford J Woolf, Guoyan Zhao

引用次数: 0

A gut-wrenching tale of neuronal distress. 一个关于神经元痛苦的令人揪心的故事。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.03.033

Murillo Duarte-Silva, Meenakshi Rao

引用次数: 0

APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease. APOE 基因型决定了阿尔茨海默病的细胞特异性病理特征。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-03-19 DOI: 10.1016/j.neuron.2025.02.017

Zonghua Li, Yuka A Martens, Yingxue Ren, Yunjung Jin, Hiroaki Sekiya, Sydney V Doss, Naomi Kouri, Monica Castanedes-Casey, Trace A Christensen, Lindsay B Miller Nevalainen, Nanaka Takegami, Kai Chen, Chia-Chen Liu, Alexandra Soto-Beasley, Baayla D C Boon, Sydney A Labuzan, Tadafumi C Ikezu, Yixing Chen, Alexander D Bartkowiak, Gisela Xhafkollari, Allison M Wetmore, David A Bennett, Ross R Reichard, Ronald C Petersen, Takahisa Kanekiyo, Owen A Ross, Melissa E Murray, Dennis W Dickson, Guojun Bu, Na Zhao

{"title":"APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease.","authors":"Zonghua Li, Yuka A Martens, Yingxue Ren, Yunjung Jin, Hiroaki Sekiya, Sydney V Doss, Naomi Kouri, Monica Castanedes-Casey, Trace A Christensen, Lindsay B Miller Nevalainen, Nanaka Takegami, Kai Chen, Chia-Chen Liu, Alexandra Soto-Beasley, Baayla D C Boon, Sydney A Labuzan, Tadafumi C Ikezu, Yixing Chen, Alexander D Bartkowiak, Gisela Xhafkollari, Allison M Wetmore, David A Bennett, Ross R Reichard, Ronald C Petersen, Takahisa Kanekiyo, Owen A Ross, Melissa E Murray, Dennis W Dickson, Guojun Bu, Na Zhao","doi":"10.1016/j.neuron.2025.02.017","DOIUrl":"10.1016/j.neuron.2025.02.017","url":null,"abstract":"The apolipoprotein E (APOE) gene is the strongest genetic risk modifier for Alzheimer's disease (AD), with the APOE4 allele increasing risk and APOE2 decreasing it compared with the common APOE3 allele. Using single-nucleus RNA sequencing of the temporal cortex from APOE2 carriers, APOE3 homozygotes, and APOE4 carriers, we found that AD-associated transcriptomic changes were highly APOE genotype dependent. Comparing AD with controls, APOE2 carriers showed upregulated synaptic and myelination-related pathways, preserving synapses and myelination at the protein level. Conversely, these pathways were downregulated in APOE3 homozygotes, resulting in reduced synaptic and myelination proteins. In APOE4 carriers, excitatory neurons displayed reduced synaptic pathways similar to APOE3, but oligodendrocytes showed upregulated myelination pathways like APOE2. However, their synaptic and myelination protein levels remained unchanged or increased. APOE4 carriers also showed increased pro-inflammatory signatures in microglia but reduced responses to amyloid-β pathology. These findings reveal APOE genotype-specific molecular alterations in AD across cell types.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"1380-1397.e7"},"PeriodicalIF":14.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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