Neuron最新文献_第8页

Sleep and the recovery from stress. 睡眠和从压力中恢复。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-17 DOI: 10.1016/j.neuron.2025.04.028

Xiao Yu, Mathieu Nollet, Nicholas P Franks, William Wisden

引用次数: 0

Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex. 多模态分析揭示了驱动灵长类前额皮质神经元电生理成熟的基因。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-14 DOI: 10.1016/j.neuron.2025.04.025

Yu Gao, Qiping Dong, Kalpana Hanthanan Arachchilage, Ryan D Risgaard, Moosa Syed, Jie Sheng, Danielle K Schmidt, Ting Jin, Shuang Liu, Soraya O Sandoval, Sara Knaack, Magnus T Eckholm, Rachel J Chen, Yu Guo, Dan Doherty, Ian Glass, Jon E Levine, Daifeng Wang, Qiang Chang, Xinyu Zhao, Andre M M Sousa

{"title":"Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex.","authors":"Yu Gao, Qiping Dong, Kalpana Hanthanan Arachchilage, Ryan D Risgaard, Moosa Syed, Jie Sheng, Danielle K Schmidt, Ting Jin, Shuang Liu, Soraya O Sandoval, Sara Knaack, Magnus T Eckholm, Rachel J Chen, Yu Guo, Dan Doherty, Ian Glass, Jon E Levine, Daifeng Wang, Qiang Chang, Xinyu Zhao, Andre M M Sousa","doi":"10.1016/j.neuron.2025.04.025","DOIUrl":"10.1016/j.neuron.2025.04.025","url":null,"abstract":"The prefrontal cortex (PFC) is critical for myriad high-cognitive functions and is associated with several neuropsychiatric disorders. Here, using Patch-seq and single-nucleus multiomic analyses, we identified genes and regulatory networks governing the maturation of distinct neuronal populations in the PFC of rhesus macaque. We discovered that specific electrophysiological properties exhibited distinct maturational kinetics and identified key genes underlying these properties. We unveiled that RAPGEF4 is important for the maturation of resting membrane potential and inward sodium current in both macaque and human. We demonstrated that knockdown of CHD8, a high-confidence autism risk gene, in human and macaque organotypic slices led to impaired maturation, via downregulation of key genes, including RAPGEF4. Restoring the expression of RAPGEF4 rescued the proper electrophysiological maturation of CHD8-deficient neurons. Our study revealed regulators of neuronal maturation during a critical period of PFC development in primates and implicated such regulators in molecular processes underlying autism.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal. 阿片类药物驱动的隔膜破坏揭示了神经紧张素表达神经元在戒断中的作用。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-14 DOI: 10.1016/j.neuron.2025.04.024

Rhiana C Simon, Weston T Fleming, Brandy A Briones, Marta Trzeciak, Pranav Senthilkumar, Kentaro K Ishii, Madelyn M Hjort, Madison M Martin, Koichi Hashikawa, Andrea D Sanders, Sam A Golden, Garret D Stuber

{"title":"Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal.","authors":"Rhiana C Simon, Weston T Fleming, Brandy A Briones, Marta Trzeciak, Pranav Senthilkumar, Kentaro K Ishii, Madelyn M Hjort, Madison M Martin, Koichi Hashikawa, Andrea D Sanders, Sam A Golden, Garret D Stuber","doi":"10.1016/j.neuron.2025.04.024","DOIUrl":"10.1016/j.neuron.2025.04.024","url":null,"abstract":"Opioid withdrawal is an intensively aversive experience and often drives relapse. The lateral septum (LS) is a forebrain structure that is important in aversion processing and has been linked to substance use disorders, but which LS cell types contribute to the maladaptive state of withdrawal is unknown. We used single-nucleus RNA sequencing to interrogate cell-type-specific gene expression changes induced by chronic morphine exposure and discovered that morphine globally disrupts LS cell types, but neurotensin-expressing neurons (LS-Nts) are selectively activated by naloxone. Using two-photon calcium imaging and ex vivo electrophysiology, we next demonstrate that LS-Nts neurons receive elevated glutamatergic drive in morphine-dependent mice and remain hyperactivated during withdrawal. Finally, we show that manipulating LS-Nts neurons during opioid withdrawal regulates pain coping and sociability. Together, these results suggest that LS-Nts neurons are a key neural substrate involved in opioid withdrawal and establish the LS as a crucial regulator of adaptive behaviors.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice. 表达p16的小胶质细胞和内皮细胞促进PS19小鼠的牛头病变和神经血管异常。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-14 DOI: 10.1016/j.neuron.2025.04.020

Sara I Graves, Charlton F Meyer, Karthik B Jeganathan, Darren J Baker

{"title":"p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice.","authors":"Sara I Graves, Charlton F Meyer, Karthik B Jeganathan, Darren J Baker","doi":"10.1016/j.neuron.2025.04.020","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.04.020","url":null,"abstract":"Cellular senescence is characterized by irreversible cell-cycle exit, a pro-inflammatory secretory phenotype, macromolecular damage, and deregulated metabolism. Senescent cells are highly associated with age-related diseases. We previously demonstrated that targeted elimination of senescent cells prevents neurodegenerative disease in tau (MAPTP301S;PS19) mutant mice. Here, we show that genetic ablation of the senescence mediator p16Ink4a is sufficient to attenuate senescence signatures in PS19 mice. Disease phenotypes-including neuroinflammation, phosphorylated tau, neurodegeneration, and cognitive impairment-were blunted in the absence of p16Ink4a. Additionally, we found that PS19 mouse brains display p16Ink4-dependent neurovascular alterations such as vessel dilation, increased vessel density, deregulated endothelial cell extracellular matrix, and astrocytic endfoot depolarization. Finally, we show that p16Ink4a deletion in endothelial cells and microglia alone attenuates many of the same phenotypes. Altogether, these results indicate that neurodegenerative disease in PS19 mice is driven, at least in part, by p16Ink4a-expressing endothelial cells and microglia.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq. 全生物体snRNA-seq揭示了Aβ42和Tau的不同全身影响。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-13 DOI: 10.1016/j.neuron.2025.04.017

Ye-Jin Park, Tzu-Chiao Lu, Tyler Jackson, Lindsey D Goodman, Lindsey Ran, Jiaye Chen, Chung-Yi Liang, Erin Harrison, Christina Ko, Xi Chen, Baiping Wang, Ao-Lin Hsu, Elizabeth Ochoa, Kevin F Bieniek, Shinya Yamamoto, Yi Zhu, Hui Zheng, Yanyan Qi, Hugo J Bellen, Hongjie Li

{"title":"Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq.","authors":"Ye-Jin Park, Tzu-Chiao Lu, Tyler Jackson, Lindsey D Goodman, Lindsey Ran, Jiaye Chen, Chung-Yi Liang, Erin Harrison, Christina Ko, Xi Chen, Baiping Wang, Ao-Lin Hsu, Elizabeth Ochoa, Kevin F Bieniek, Shinya Yamamoto, Yi Zhu, Hui Zheng, Yanyan Qi, Hugo J Bellen, Hongjie Li","doi":"10.1016/j.neuron.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.neuron.2025.04.017","url":null,"abstract":"Both neuronal and peripheral tissues become disrupted in Alzheimer's disease (AD). However, a comprehensive understanding of how AD impacts different tissues across the whole organism is lacking. Using Drosophila, we generated an AD Fly Cell Atlas (AD-FCA) based on whole-organism single-nucleus transcriptomes of 219 cell types from flies expressing AD-associated proteins, either human amyloid-β 42 peptide (Aβ42) or Tau, in neurons. We found that Aβ42 primarily affects the nervous system, including sensory neurons, while Tau induces accelerated aging in peripheral tissues. We identified a neuronal cluster enriched in Aβ42 flies, which has high lactate dehydrogenase (LDH) expression. This LDH-high cluster is conserved in 5XFAD mouse and human AD datasets. We found a conserved defect in fat metabolism from both fly and mouse tauopathy models. The AD-FCA offers new insights into how Aβ42 or Tau systemically and differentially affects a whole organism and provides a valuable resource for understanding brain-body communication in neurodegeneration.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network influence determines the impact of cortical ensembles on stimulus detection. 网络影响决定了皮层集合对刺激检测的影响。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-13 DOI: 10.1016/j.neuron.2025.04.023

Hayley A Bounds, Hillel Adesnik

引用次数: 0

Neural circuit underlying individual differences in visual escape habituation. 视觉逃避习惯个体差异背后的神经回路。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-08 DOI: 10.1016/j.neuron.2025.04.018

Xuemei Liu, Juan Lai, Chuanliang Han, Hao Zhong, Kang Huang, Yuanming Liu, Xutao Zhu, Pengfei Wei, Liming Tan, Fuqiang Xu, Liping Wang

引用次数: 0

An unexpected mediator of pain-driven opioid use in males-estrogen. 男性疼痛驱动阿片类药物使用的意想不到的中介-雌激素。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.008

Rebecca M Shansky

引用次数: 0

NAD⁺ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. NAD+通过CX43-PARP1轴修复衰老诱导的血脑屏障损伤。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 Epub Date: 2025-04-17 DOI: 10.1016/j.neuron.2025.04.002

Rui Zhan, Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, Dehua Chui, Y Eugene Chen, Zheng Sun, Erdan Dong, Yongjun Wang, Lemin Zheng

引用次数: 0

The nervous system and cancer: A grand challenge and a call to collaborate. 神经系统和癌症：一个巨大的挑战和合作的呼吁。

IF 14.7 1区医学

Neuron Pub Date : 2025-05-07 DOI: 10.1016/j.neuron.2025.04.009

Gabriela Carreno, Gemma M Balmer, Rebecca L Eccles

引用次数: 0