IF 14.7 1区医学

Neuron Pub Date : 2024-10-07 DOI: 10.1016/j.neuron.2024.09.009

Anna Zhukovskaya, Christopher A Zimmerman, Lindsay Willmore, Alejandro Pan-Vazquez, Sanjeev R Janarthanan, Laura A Lynch, Annegret L Falkner, Ilana B Witten

{"title":"Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility.","authors":"Anna Zhukovskaya, Christopher A Zimmerman, Lindsay Willmore, Alejandro Pan-Vazquez, Sanjeev R Janarthanan, Laura A Lynch, Annegret L Falkner, Ilana B Witten","doi":"10.1016/j.neuron.2024.09.009","DOIUrl":"10.1016/j.neuron.2024.09.009","url":null,"abstract":"Some individuals are susceptible to chronic stress, and others are more resilient. While many brain regions implicated in learning are dysregulated after stress, little is known about whether and how neural teaching signals during stress differ between susceptible and resilient individuals. Here, we seek to determine if activity in the lateral habenula (LHb), which encodes a negative teaching signal, differs between susceptible and resilient mice during stress to produce different outcomes. After (but not before) chronic social defeat stress, the LHb is active when susceptible mice are in proximity of the aggressor strain. During stress, activity is higher in susceptible mice during aggressor interactions, and activation biases mice toward susceptibility. This manipulation generates a persistent and widespread increase in the balance of subcortical vs. cortical activity in susceptible mice. Taken together, our results indicate that heightened activity in the LHb during stress produces lasting brainwide and behavioral substrates of susceptibility.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social status as a latent variable in the amygdala of observers of social interactions. 社会地位是社会互动观察者杏仁核中的一个潜在变量。

IF 14.7 1区医学

Neuron Pub Date : 2024-10-03 DOI: 10.1016/j.neuron.2024.09.010

SeungHyun Lee, Ueli Rutishauser, Katalin M Gothard

引用次数: 0

A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice. 下丘脑-后脑回路中的一小部分应激反应神经元介导了小鼠抑郁样行为的发展。

IF 14.7 1区医学

Neuron Pub Date : 2024-10-03 DOI: 10.1016/j.neuron.2024.09.012

Zhiwei Zheng, Yiqin Liu, Ruiqi Mu, Xiaonan Guo, Yirong Feng, Chen Guo, Liang Yang, Wenxi Qiu, Qi Zhang, Wei Yang, Zhaoqi Dong, Shuang Qiu, Yiyan Dong, Yihui Cui

{"title":"A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice.","authors":"Zhiwei Zheng, Yiqin Liu, Ruiqi Mu, Xiaonan Guo, Yirong Feng, Chen Guo, Liang Yang, Wenxi Qiu, Qi Zhang, Wei Yang, Zhaoqi Dong, Shuang Qiu, Yiyan Dong, Yihui Cui","doi":"10.1016/j.neuron.2024.09.012","DOIUrl":"https://doi.org/10.1016/j.neuron.2024.09.012","url":null,"abstract":"Accumulating evidence has shown that various brain functions are associated with experience-activated neuronal ensembles. However, whether such neuronal ensembles are engaged in the pathogenesis of stress-induced depression remains elusive. Utilizing activity-dependent viral strategies in mice, we identified a small population of stress-responsive neurons, primarily located in the middle part of the lateral hypothalamus (mLH) and the medial part of the lateral habenula (LHbM). These neurons serve as \"starter cells\" to transmit stress-related information and mediate the development of depression-like behaviors during chronic stress. Starter cells in the mLH and LHbM form dominant connections, which are selectively potentiated by chronic stress. Silencing these connections during chronic stress prevents the development of depression-like behaviors, whereas activating these connections directly elicits depression-like behaviors without stress experience. Collectively, our findings dissect a core functional unit within the LH-LHb circuit that mediates the development of depression-like behaviors in mice.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":14.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquiring musculoskeletal skills with curriculum-based reinforcement learning. 通过基于课程的强化学习掌握肌肉骨骼技能。

IF 14.7 1区医学

Neuron Pub Date : 2024-10-01 DOI: 10.1016/j.neuron.2024.09.002

Alberto Silvio Chiappa, Pablo Tano, Nisheet Patel, Abigaïl Ingster, Alexandre Pouget, Alexander Mathis

引用次数: 0

Regenerating enteric neurites navigate the adult intestine using a glial positioning system? 再生肠神经元利用神经胶质定位系统为成人肠道导航？

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.08.023

Candice Fung, Pieter Vanden Berghe

引用次数: 0

Protective lifelines: Tunneling nanotubes connect neurons and microglia. 保护生命线隧道纳米管连接神经元和小胶质细胞

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.07.027

Jonas J Neher, Mikael Simons

引用次数: 0

A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets. 单细胞图谱解构了小鼠创伤性脑损伤多种模型的异质性，并确定了新的细胞特异性靶标。

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 Epub Date: 2024-07-16 DOI: 10.1016/j.neuron.2024.06.021

Ruchira M Jha, Dhivyaa Rajasundaram, Chaim Sneiderman, Brent T Schlegel, Casey O'Brien, Zujian Xiong, Keri Janesko-Feldman, Ria Trivedi, Vincent Vagni, Benjamin E Zusman, Joshua S Catapano, Adam Eberle, Shashvat M Desai, Ashutosh P Jadhav, Sandra Mihaljevic, Margaux Miller, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shima Shahjouie, Itay Raphael, Aditya Kumar, Chia-Ling Phuah, Ethan A Winkler, Dennis W Simon, Patrick M Kochanek, Gary Kohanbash

{"title":"A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets.","authors":"Ruchira M Jha, Dhivyaa Rajasundaram, Chaim Sneiderman, Brent T Schlegel, Casey O'Brien, Zujian Xiong, Keri Janesko-Feldman, Ria Trivedi, Vincent Vagni, Benjamin E Zusman, Joshua S Catapano, Adam Eberle, Shashvat M Desai, Ashutosh P Jadhav, Sandra Mihaljevic, Margaux Miller, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shima Shahjouie, Itay Raphael, Aditya Kumar, Chia-Ling Phuah, Ethan A Winkler, Dennis W Simon, Patrick M Kochanek, Gary Kohanbash","doi":"10.1016/j.neuron.2024.06.021","DOIUrl":"10.1016/j.neuron.2024.06.021","url":null,"abstract":"Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies. Identifying final common pathways/molecular signatures that integrate this heterogeneity informs biomarker and therapeutic-target development. We present the first large-scale murine single-cell atlas of the transcriptomic response to TBI (334,376 cells) across clinically relevant models, sex, brain region, and time as a foundational step in molecularly deconstructing TBI heterogeneity. Results were unique to cell populations, injury models, sex, brain regions, and time, highlighting the importance of cell-level resolution. We identify cell-specific targets and previously unrecognized roles for microglial and ependymal subtypes. Ependymal-4 was a hub of neuroinflammatory signaling. A distinct microglial lineage shared features with disease-associated microglia at 24 h, with persistent gene-expression changes in microglia-4 even 6 months after contusional TBI, contrasting all other cell types that mostly returned to naive levels. Regional and sexual dimorphism were noted. CEREBRI, our searchable atlas (https://shiny.crc.pitt.edu/cerebri/), identifies previously unrecognized cell subtypes/molecular targets and is a leverageable platform for future efforts in TBI and other diseases with overlapping pathophysiology.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3069-3088.e4"},"PeriodicalIF":14.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezo1 ion channels are capable of conformational signaling. Piezo1 离子通道能够进行构象信号转导。

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 Epub Date: 2024-07-22 DOI: 10.1016/j.neuron.2024.06.024

Amanda H Lewis, Marie E Cronin, Jörg Grandl

{"title":"Piezo1 ion channels are capable of conformational signaling.","authors":"Amanda H Lewis, Marie E Cronin, Jörg Grandl","doi":"10.1016/j.neuron.2024.06.024","DOIUrl":"10.1016/j.neuron.2024.06.024","url":null,"abstract":"Piezo1 is a mechanically activated ion channel that senses forces with short latency and high sensitivity. Piezos undergo large conformational changes, induce far-reaching deformation onto the membrane, and modulate the function of two-pore potassium (K2P) channels. Taken together, this led us to hypothesize that Piezos may be able to signal their conformational state to other nearby proteins. Here, we use chemical control to acutely restrict Piezo1 conformational flexibility and show that Piezo1 conformational changes, but not ion permeation through them, are required for modulating the K2P channel K2P2.1 (TREK1). Super-resolution imaging and stochastic simulations further reveal that both channels do not co-localize, which implies that modulation is not mediated through direct binding interactions; however, at high Piezo1 densities, most TREK1 channels are within the predicted Piezo1 membrane footprint, suggesting that the footprint may underlie conformational signaling. We speculate that physiological roles originally attributed to Piezo1 ionotropic function could, alternatively, involve conformational signaling.","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":"3161-3175.e5"},"PeriodicalIF":14.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cori Bargmann. 科里-巴尔格曼

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.09.008

Cori Bargmann

引用次数: 0

An abstract linguistic space for transmitting information from one mind to another. 一种抽象的语言空间，用于将信息从一个思维传递到另一个思维。

IF 14.7 1区医学

Neuron Pub Date : 2024-09-25 DOI: 10.1016/j.neuron.2024.09.005

Greta Tuckute, Evelina Fedorenko

引用次数: 0

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