Microglial ADGRG1: AD glial resilience generator.

IF 15 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-10-01 DOI:10.1016/j.neuron.2025.09.003

Kia M Barclay, Qingyun Li

引用次数: 0

Abstract

Microglial states underlying Alzheimer's disease (AD) have been well characterized in animal models and human samples, yet their regulation remains elusive. In this issue of Neuron, Zhu et al.¹ uncover Adgrg1, which governs a protective microglia phenotype through MYC activation.

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小胶质ADGRG1: AD胶质弹性发生器。

阿尔茨海默病（AD）背后的小胶质细胞状态已经在动物模型和人类样本中得到了很好的表征，但它们的调控仍然是难以捉摸的。在这一期的Neuron杂志上，Zhu等人发现了Adgrg1，它通过MYC激活来控制保护性小胶质细胞表型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.