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Waterpipe Size Matters: The Effect of Waterpipe Size on Toxicant Exposures and Subjective Experiences. 水烟大小很重要:水烟大小对毒物暴露和主观体验的影响。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntae229
Danny Dabroy, Steven Alec Barrientos, Mohammed Ebrahimi Kalan, Ahmed Alarabi, Kevin Schug, Roman Goff, Sabrina Islam, Caroline O Cobb, Ziyad Ben Taleb
{"title":"Waterpipe Size Matters: The Effect of Waterpipe Size on Toxicant Exposures and Subjective Experiences.","authors":"Danny Dabroy, Steven Alec Barrientos, Mohammed Ebrahimi Kalan, Ahmed Alarabi, Kevin Schug, Roman Goff, Sabrina Islam, Caroline O Cobb, Ziyad Ben Taleb","doi":"10.1093/ntr/ntae229","DOIUrl":"10.1093/ntr/ntae229","url":null,"abstract":"<p><strong>Introduction: </strong>Waterpipe (WP) tobacco smoking remains popular among US young adults, yet specific regulations for WP devices are lacking. This study examines how WP device size (base volume and height) affects smoking behavior, toxicant exposures, and subjective experiences.</p><p><strong>Aims and methods: </strong>Thirty-eight individuals who smoke WP aged 21-39 participated in a randomized crossover study. Each completed three 45-min ad libitum smoking sessions using small, medium, and large WP sizes. Saliva nicotine and exhaled carbon monoxide (eCO) were measured before and after smoking. Puff topography was recorded during sessions, and subjective smoking experiences were collected afterwards.</p><p><strong>Results: </strong>Significant differences were observed in saliva nicotine between the three WP sizes, with higher concentrations for the small WP relative to larger sizes (p < .05). Exhaled CO was significantly higher after smoking the large WP compared to smaller sizes (p < .05). Puff topography revealed significant differences and followed a dose-response pattern, with larger size associated with longer puff duration, greater smoke volume inhaled, and larger puff volume (p < .05). The large WP was associated with enhanced subjective experiences for satisfaction and concentration compared to the small WP (p < .05).</p><p><strong>Conclusions: </strong>WP size substantially impacts smoking experiences and exposures. Regulation of WP size should be essential in comprehensive tobacco control policies aimed at curbing WP use among young adults. These findings will aid in the developing of WP size-specific standards to regulate the marketing and sales of WP devices. Such regulations should aim to minimize toxicant exposure by controlling the dimensions and design of WP components, which can significantly influence smoking behavior and toxicant intake.</p><p><strong>Implications: </strong>This study underscores the critical role of waterpipe (WP) size in shaping smoking behavior, experiences, and exposures among young adults.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1227-1235"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Constituents and Particle Size Distribution of Mainstream Emission From Electronic Waterpipe. 电子水管主流排放物的化学成分及粒径分布。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntaf028
Theodore P Klupinski, Anna Adetona, Alexander Ivanov, Aaron Richardson, Erich D Strozier, Laura L S Aume, Hani Karam, Stephanie D Makselan, Martha McCauley, Larry Mullins, Billie Stiffler, Eric A Lucas, Hyoshin Kim
{"title":"Chemical Constituents and Particle Size Distribution of Mainstream Emission From Electronic Waterpipe.","authors":"Theodore P Klupinski, Anna Adetona, Alexander Ivanov, Aaron Richardson, Erich D Strozier, Laura L S Aume, Hani Karam, Stephanie D Makselan, Martha McCauley, Larry Mullins, Billie Stiffler, Eric A Lucas, Hyoshin Kim","doi":"10.1093/ntr/ntaf028","DOIUrl":"10.1093/ntr/ntaf028","url":null,"abstract":"<p><strong>Introduction: </strong>An electronic waterpipe (electronic hookah) uses an electronic heating element to promote the vaporization and aerosolization of an e-liquid in a waterpipe. There is little or no published information characterizing the toxicant levels or particle size distributions (PSDs) of electronic waterpipe mainstream emission.</p><p><strong>Methods: </strong>Controlled laboratory experiments were performed to evaluate electronic waterpipe mainstream emission for 40 test conditions: 10 e-liquid products × 2 power settings × 2 puffing topographies. Data were collected for amounts of three volatile toxicants and selected semi-volatile compounds, mass of total particulate matter, and PSD within the size range of 5-1000 nm.</p><p><strong>Results: </strong>Amounts of the volatile toxicants acetaldehyde, acrolein, and benzene measured in mainstream emission were 33-505 µg/session, 27-415 µg/session, and 0.69-2.44 µg/session, respectively. The amounts of acetaldehyde and acrolein, when reported in units of µg/puff, are generally similar to some literature-reported amounts in e-cigarette mainstream emission and tobacco waterpipe smoke. A bimodal or trimodal PSD was typically observed, and substantial concentrations of nanoparticles were detected. The amounts (in µg/puff) of the volatile toxicants and several quantitative measures of PSD were significantly affected by power setting and puffing topography.</p><p><strong>Conclusions: </strong>Given the hazards of acetaldehyde and acrolein and the distinctive toxicological profile of nanoparticles, electronic waterpipe use may present significant toxicity concerns. Operation of an electronic waterpipe is a complex process in which physics, fluid dynamics, and chemistry interact to yield mainstream emission for which the composition is sensitive to changes from various sources.</p><p><strong>Implications: </strong>This publication, to our knowledge, is the first to report the amounts of toxicants and PSDs in electronic waterpipe mainstream emission. The results reported herein suggest that there may be significant toxicity concerns associated with electronic waterpipe use as indicated by the levels of volatile toxicants and the presence of nanoparticles in electronic waterpipe mainstream emission. This knowledge is valuable to support the research community and tobacco regulatory agencies in understanding the impact that electronic waterpipe use may have on public health.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1265-1273"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating Young Adult Uptake of Smoking by Area Across the United Kingdom. 英国各地区青少年吸烟率估算。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntae231
Sarah E Jackson, Harry Tattan-Birch, Nicholas S Hopkinson, Jamie Brown, Lion Shahab, Laura Bunce, Anthony A Laverty, Deborah Arnott
{"title":"Estimating Young Adult Uptake of Smoking by Area Across the United Kingdom.","authors":"Sarah E Jackson, Harry Tattan-Birch, Nicholas S Hopkinson, Jamie Brown, Lion Shahab, Laura Bunce, Anthony A Laverty, Deborah Arnott","doi":"10.1093/ntr/ntae231","DOIUrl":"10.1093/ntr/ntae231","url":null,"abstract":"<p><strong>Introduction: </strong>There is majority support in parliament and across the United Kingdom to implement a \"smoke-free generation\" policy which would mean people born on or after January 1, 2009, could never legally be sold tobacco. To explore the potential impact this policy could have, we estimated the number of young adults (18-25 years) currently taking up smoking each year by area across the United Kingdom.</p><p><strong>Methods: </strong>Using data from the Office for National Statistics (ONS), Annual Population Survey (APS), and Smoking Toolkit Study (STS), we estimated the total number of 18- to 25-year-olds taking up smoking each year, based on national estimates of population size (ONS) and the proportion who reported ever having regularly smoked (STS). We used local data on adult smoking rates (APS) to apportion the national estimated number of young adults taking up smoking to specific areas.</p><p><strong>Results: </strong>Around 127 500 18- to 25-year-olds in the United Kingdom start smoking regularly each year (~350 each day); 105 700 each year in England, 11 500 in Scotland, 6500 in Wales, and 3800 in Northern Ireland. Uptake estimates varied across localities: for example, North East Lincolnshire had the highest proportion of young adults taking up smoking each year (3.9%) and Wokingham had the lowest (0.9%).</p><p><strong>Conclusions: </strong>Despite reductions in smoking prevalence over recent decades, hundreds of young adults in the United Kingdom start smoking every day.</p><p><strong>Implications: </strong>Data on rates of uptake among individual local authorities can be used to focus attention locally prior to the introduction of new age of sale laws.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1300-1305"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smoking Behavior and Social Identity: Correlates of Phantom Smoking Among Lesbian, Gay, Bisexual, Transgender, and Other Sexual and Gender Diverse Young Adults. 吸烟行为与社会身份:女同性恋、男同性恋、双性恋、变性人和其他性取向与性别多元化的年轻成年人中幻影吸烟的相关因素》(Correlates of Phantom Smoking Among Lesbian, Gay, Bisexual, Transgender, and Other Sexual and Gender Diverse Young Adults)。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntae252
Jamie Guillory, Erik Crankshaw, Ishrat Z Alam, Laurel Curry, McKinley Saunders, Andie Malterud, Alex Budenz, Leah Hoffman, Ollie Ganz, Allison Alexander
{"title":"Smoking Behavior and Social Identity: Correlates of Phantom Smoking Among Lesbian, Gay, Bisexual, Transgender, and Other Sexual and Gender Diverse Young Adults.","authors":"Jamie Guillory, Erik Crankshaw, Ishrat Z Alam, Laurel Curry, McKinley Saunders, Andie Malterud, Alex Budenz, Leah Hoffman, Ollie Ganz, Allison Alexander","doi":"10.1093/ntr/ntae252","DOIUrl":"10.1093/ntr/ntae252","url":null,"abstract":"<p><strong>Introduction: </strong>LGBTQ+ populations and people who smoke face stigma. This may lead to distancing oneself from smoking-related stigma by becoming a phantom smoker (i.e., reporting smoking, but not identifying as a smoker).</p><p><strong>Aims and methods: </strong>We explored correlates of phantom cigarette smoking among LGBTQ+ young adults. Participants were US young adults (18-24 years) who identified as LGBTQ+, reported any past 30-day cigarette smoking, and had a valid response for smoker self-identification (unique N = 5545). We incorporated data from participants who completed one or more of the seven surveys from the FDA's This Free Life campaign evaluation (February 2016-July 2019). Multivariable panel regression models with unweighted data examined phantom smoking correlates.</p><p><strong>Results: </strong>Over 60% of the sample were phantom smokers. Compared with self-identified smokers, phantom smokers were younger, more likely to be gay men than lesbian/gay women, and more likely to be non-Hispanic White than non-Hispanic Black, Hispanic, or non-Hispanic people of other races/ethnicities. Phantom smokers were more likely to have a college plus education (vs. high school or less) and report past 30-day alcohol use. Phantom smokers smoked on fewer of the past 30 days and were less likely to report positive cessation attitudes, nicotine dependence, and current e-cigarette or other tobacco product use.</p><p><strong>Conclusions: </strong>This is the first known study to explore factors associated with phantom smoking among LGBTQ+ young adults. Over half of young adult smokers were phantom smokers. Tobacco education for LGBTQ+ populations should consider phantom smoking and cessation implications to tailor content for phantom and self-identified smokers.</p><p><strong>Implications: </strong>We examined predictors of phantom smoking (current smoking but denying smoker identity) among LGBTQ+ young adult smokers, which has not yet been explored among this population. Phantom (vs. self-identified) smokers were less likely to be lesbian/gay women (vs. gay men) or from a racial/ethnic minority group and more likely to report past 30-day alcohol use. Phantom smokers reported less tobacco use, lower nicotine dependence, and less favorable cessation attitudes. Phantom smokers comprised most smokers in our sample. Findings suggest the importance of addressing this unique aspect of LGBTQ+ smoking in research, clinical settings, and tailored tobacco public education messages.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1247-1255"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Cigarette-E-Cigarette Transitions With Respiratory Symptom Resolution. 卷烟-卷烟转换与呼吸道症状缓解的关系
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntae224
Jonathan B Berlowitz, Wubin Xie, Alyssa F Harlow, Hasmeena Kathuria, Emelia J Benjamin, Andrew C Stokes
{"title":"Association of Cigarette-E-Cigarette Transitions With Respiratory Symptom Resolution.","authors":"Jonathan B Berlowitz, Wubin Xie, Alyssa F Harlow, Hasmeena Kathuria, Emelia J Benjamin, Andrew C Stokes","doi":"10.1093/ntr/ntae224","DOIUrl":"10.1093/ntr/ntae224","url":null,"abstract":"<p><strong>Introduction: </strong>Adults increasingly use e-cigarettes for cigarette cessation because of the perceived reduced risk. While e-cigarette use is associated with reduced toxicant exposure compared with smoking, it is unclear whether transitioning from cigarettes to e-cigarettes is associated with resolution of respiratory symptoms.</p><p><strong>Methods: </strong>Data were obtained from the Population Assessment of Tobacco and Health (PATH) study waves 1-5. US adult participants were separated into observations with cigarette-e-cigarette exposure intervals determined from PATH waves 1-2, 2-3, and 3-4. Observations were included if the participant reported exclusively smoking at baseline and reported a baseline cough or wheeze. Mixed-effect Poisson models measured the association between cigarette-e-cigarette transitions over the two-wave exposure interval (from smoking to nonuse, exclusive e-cigarette use, continued smoking, or dual use) and the reported resolution of the participant's cough or wheeze.</p><p><strong>Results: </strong>Among 5210 (3362 unique) observations, transitioning from cigarettes to e-cigarettes was associated with increased rates of wheeze resolution (incidence rate ratio [IRR] = 1.33; 95% confidence interval [CI] = 1.01 to 1.75) but not cough resolution (IRR = 1.18; 95% CI = 0.93 to 1.50) compared with persistent smoking. Cigarette to dual-use transitions were not associated with improvements in symptom resolution, and those who switched to dual use and maintained or increased their smoking intensity had 15% decreased rates of respiratory symptom resolution compared with persistent smoking.</p><p><strong>Discussion: </strong>E-cigarette-assisted smoking cessation may increase rates of respiratory symptoms resolution among smokers who completely transition to e-cigarettes; however, there is risk for additional harm among those who initiate e-cigarette use without decreasing their smoking intensity.</p><p><strong>Implications: </strong>Government agencies are increasingly weighing the risks and benefits of e-cigarette-assisted cigarette cessation given the reduced harm associated with e-cigarette use. This study provides novel evidence that completely transitioning from cigarettes to e-cigarettes is associated with increased rates of resolution from self-reported wheeze symptoms. However, risk exists in e-cigarette-assisted cigarette cessation, as those who transitioned from exclusive cigarette smoking to dual use and did not reduce their cigarette smoking intensity had decreased rates of respiratory symptom resolution compared with persistent smokers.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1284-1288"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Seeing Cigarettes in the Retail Environment Associated With Impulse Purchases? Findings From Surveys in Disadvantaged and Non-disadvantaged Neighborhoods in the Netherlands. 在零售环境中看到香烟与冲动消费有关吗?对荷兰弱势和非弱势社区的调查结果。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntaf026
Nikita L Poole, Floor A van den Brand, Marc C Willemsen, Gera E Nagelhout
{"title":"Is Seeing Cigarettes in the Retail Environment Associated With Impulse Purchases? Findings From Surveys in Disadvantaged and Non-disadvantaged Neighborhoods in the Netherlands.","authors":"Nikita L Poole, Floor A van den Brand, Marc C Willemsen, Gera E Nagelhout","doi":"10.1093/ntr/ntaf026","DOIUrl":"10.1093/ntr/ntaf026","url":null,"abstract":"<p><strong>Background: </strong>The retail environment plays an important role in impulse purchase behavior. This study aims to examine the extent to which different sources of exposure to tobacco in the Dutch retail environment are associated with impulse purchases of tobacco. We investigate whether this association differs based on neighborhood disadvantage, demographic and smoking characteristics.</p><p><strong>Aims and methods: </strong>We employed a cross-sectional online survey design among 1223 Dutch adults who smoke from a probability-based panel database, with half residing in a disadvantaged neighborhood. We conducted multiple logistic regression analyses for impulse purchases with six sources of reported tobacco exposure in the retail environment. We tested for interactions with neighborhood disadvantage, demographic and smoking characteristics.</p><p><strong>Results: </strong>Five sources of exposure were associated with impulse purchases: seeing cigarette packages at the counter or checkout, tobacco advertisements, people smoking by the shop entrance, a friend buying cigarettes and a family member buying cigarettes. We found one significant interaction in the relationship between exposure and impulse purchases by previous quit attempts. Individuals who have attempted or intend to quit, younger respondents, and frequent tobacco purchasers were more likely to be exposed to tobacco and make impulse purchases. Living in a disadvantaged neighborhood was associated with greater exposure to tobacco in the retail environment.</p><p><strong>Conclusions: </strong>Several sources of exposure to tobacco in the retail environment, most notably seeing cigarettes at the checkout and family buying cigarettes, are associated with impulse tobacco purchases. These findings provide support for limiting the sale of tobacco to specialist shops to prevent impulse purchases.</p><p><strong>Implications: </strong>This study shows that even with a point-of-sale display ban, several other types of exposure to tobacco in the retail environment may trigger adults who smoke to make an impulse purchase. We provide further evidence that certain groups are at an increased risk of being exposed to tobacco and making impulse purchases. This study provides support for limiting the sale of tobacco to specialist shops. These findings are directly relevant not only for the Netherlands, but for other nations considering their next steps for tobacco control.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1274-1283"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Socioeconomic Variation in Tobacco Smoking Among the Adult Population in Ireland. 爱尔兰成年人吸烟的社会经济差异。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntae245
Gintare Valentelyte, Aishling Sheridan, Paul Kavanagh, Frank Doyle, Jan Sorensen
{"title":"Socioeconomic Variation in Tobacco Smoking Among the Adult Population in Ireland.","authors":"Gintare Valentelyte, Aishling Sheridan, Paul Kavanagh, Frank Doyle, Jan Sorensen","doi":"10.1093/ntr/ntae245","DOIUrl":"10.1093/ntr/ntae245","url":null,"abstract":"<p><strong>Introduction: </strong>Differences in smoking prevalence across socioeconomic groups are a major driver of health inequalities. Although smoking prevalence continues to decline across most developed countries, socioeconomic inequalities in smoking still persist. While Ireland is among a small number of countries with a tobacco-endgame goal set to achieve a smoking prevalence of 5% by 2025, the challenge this presents by socioeconomic status is uncharted.</p><p><strong>Aims and methods: </strong>We analyzed how differences in smoking status across various socioeconomic groups have changed over time in the adult population in Ireland. We used cross-sectional smoking data from the national population-based Healthy Ireland Survey for 2015-2022 (n = 52 494). Educational attainment and area-based deprivation were used as socioeconomic indicators. Socioeconomic differences and changes in inequality over time were identified using the relative index of inequality (RII). Multinomial logistic regression was used to analyze the association between socioeconomic status and daily smoking, occasional smoking, former smoking, and never smoking with adjustment for sex, age, and survey year.</p><p><strong>Results: </strong>We observed the highest daily smoking rates among the least educated (OR = 11.62; 95% CI = 9.91, 13.63) and individuals living in the most deprived areas (OR = 4.23; 95% CI = 3.55, 5.04). Additionally, we identified significant relative smoking inequalities over the observation period continued to increase, among the least educated (RII = 2.86, 95%CI = 2.63, 3.09) and individuals living in the most deprived areas (RII = 2.64, 95% CI = 2.36, 2.93).</p><p><strong>Conclusions: </strong>Despite generally reducing smoking prevalence, socioeconomic inequalities continue to widen among the smoking population in Ireland.</p><p><strong>Implications: </strong>As the tobacco endgame deadline of 2025 is fast approaching, this study highlights the urgent need to consider potential effects across the lowest socioeconomic status groups when implementing equity-oriented tobacco control policies.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1218-1226"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Predictors of Treatment Response to GLP-1 Receptor Agonists for Smoking Cessation. 探索GLP-1受体激动剂对戒烟治疗反应的预测因素。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntaf005
Luba Yammine, Constanza de Dios, Robert Suchting, Charles E Green, David A Nielsen, Consuelo Walss-Bass, Joy M Schmitz
{"title":"Exploring Predictors of Treatment Response to GLP-1 Receptor Agonists for Smoking Cessation.","authors":"Luba Yammine, Constanza de Dios, Robert Suchting, Charles E Green, David A Nielsen, Consuelo Walss-Bass, Joy M Schmitz","doi":"10.1093/ntr/ntaf005","DOIUrl":"10.1093/ntr/ntaf005","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding predictors of smoking cessation medication efficacy facilitates the ability to enhance treatment effectiveness. In our pilot trial, exenatide, a glucagon-like peptide-1 receptor agonist, adjunct to nicotine patch improved smoking abstinence compared to nicotine patch alone. This secondary analysis explores potential baseline characteristics associated with differential treatment response to exenatide.</p><p><strong>Aims and methods: </strong>The parent trial randomized (1:1) 84 smokers with prediabetes and/or overweight to once-weekly placebo or exenatide, 2 mg, subcutaneously. All participants received nicotine patch (21 mg) and brief smoking cessation counseling, with biologically confirmed 7-day point prevalence abstinence at week 6 (end-of-treatment) deemed the primary outcome. Bayesian generalized linear modeling explored differential response to treatment as a function of baseline patient characteristics, including demographic, psychosocial, clinical, smoking-related, and genetic factors. Posterior probability (PP) ≥ 75% that an effect exists was taken as a minimum threshold of evidence in favor of model effects.</p><p><strong>Results: </strong>Exenatide showed stronger benefit versus placebo in participants who smoked >20 cigarettes per day (PP = 81.7%) and in those without prediabetes (PP = 76.0%) or obesity (PP = 94.4%). Exenatide's efficacy was observed only in individuals with no/minimal depression symptoms but not in those with symptoms (PP = 91.2%). Finally, exenatide was more efficacious than placebo only in those with the CHRNA rs16969968 GG genotype (PP = 88.6%).</p><p><strong>Conclusions: </strong>The effect of exenatide on abstinence may be moderated by the number of cigarettes smoked daily, metabolic, psychological, and genetic factors. Larger prospective investigations are needed to confirm and extend these findings.</p><p><strong>Implications: </strong>Understanding predictors of smoking cessation medication efficacy enhances the ability to improve treatment effectiveness. In our pilot trial, extended-release exenatide, a GLP-1 receptor agonist, adjunct to nicotine patch, improved smoking abstinence in smokers with prediabetes and/or overweight. The current post-hoc analysis found that the effect of exenatide on smoking abstinence may be moderated by the number of cigarettes smoked daily, metabolic, psychological, and genetic factors. Larger investigations are needed to confirm and extend these findings.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1294-1300"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lost in the Smoke: Underrepresentation of Aging Adults in Nicotine and Tobacco Research. 迷失在烟雾中:老年人在尼古丁和烟草研究中的代表性不足。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntaf029
Bethea A Kleykamp, Hannah Smith, Mahima Dewan, Leanna M Kalinowski, Jacob Parsky, Jessica A Kulak
{"title":"Lost in the Smoke: Underrepresentation of Aging Adults in Nicotine and Tobacco Research.","authors":"Bethea A Kleykamp, Hannah Smith, Mahima Dewan, Leanna M Kalinowski, Jacob Parsky, Jessica A Kulak","doi":"10.1093/ntr/ntaf029","DOIUrl":"10.1093/ntr/ntaf029","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1311-1312"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Words Matter-A Call for Consistent and Accurate Scientific Language. 语言很重要——呼吁使用一致而准确的科学语言。
IF 3 2区 医学
Nicotine & Tobacco Research Pub Date : 2025-06-23 DOI: 10.1093/ntr/ntaf073
Caitlin Notley
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