Nicotine & Tobacco Research最新文献

{"title":"Parental nicotine exposure reconfigures prefrontal H3K9 acetylation and H3K4 dimethylation and induces enduring affective and nociceptive phenotypes in male rat offspring.","authors":"Seyedehfatemeh Hosseini, Maryam Bananej, Ramin Hajikhani, Mohammadreza Zarrindast, Ghorbangol Ashabi","doi":"10.1093/ntr/ntag043","DOIUrl":"https://doi.org/10.1093/ntr/ntag043","url":null,"abstract":"<p><strong>Introduction: </strong>Research has shown that nicotine exposure during gestation and early life stages can exert lasting effects on offspring, spanning multiple domains of study. This study investigates the lasting effects of nicotine exposure on the offspring of nicotine-abstinent parents on behavioral and molecular traits.</p><p><strong>Methods: </strong>Wistar rats were divided into five groups: Naïve, control, maternal nicotine exposure (MNE), paternal nicotine exposure (PNE), and combined MNE + PNE. Parents were injected with nicotine at a dose of 1 mg/kg twice daily, 6 hours apart, for 30 days, and 10 days after nicotine exposure, they were transferred to designated groups in cages for pregnancy. Behavioral assessments included conditioned place preference (CPP), elevated plus maze, open field, forced swimming test (FST), and formalin tests on male offspring after 60 days. The prefrontal cortex was analyzed for neuronal death and histone modifications.</p><p><strong>Results: </strong>Offspring in the MNE and MNE + PNE groups showed significantly decreased CPP scores compared to controls. Anxiety-like behaviors were evident across all experimental groups, with increased immobility in FST indicating depression-like behavior. The MNE + PNE group exhibited heightened pain responses compared to controls. Histological analysis revealed neuronal death and elevated caspase-3 activity in the prefrontal cortex across all groups.</p><p><strong>Conclusions: </strong>Epigenetic changes included lower levels of acetylated H3K9 and higher levels of di-methylated H3K4, showing that parental nicotine exposure significantly affected how genes are regulated. These findings highlight the enduring impact of parental nicotine exposure on offspring behavior and molecular pathways, emphasizing the need to understand the transgenerational effects of substance exposure.</p><p><strong>Implications: </strong>This study provides new evidence that parental nicotine exposure, even after a period of abstinence, leads to significant behavioral and epigenetic alterations in male rat offspring. These results underscore the enduring and transgenerational impact of nicotine, highlighting the importance of considering parental substance use history in understanding offspring neurodevelopmental and behavioral outcomes.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society for Research on Nicotine and Tobacco Europe Debate: Mandated reduction of nicotine in tobacco products is not the logical next step.","authors":"Katherine East, Kenneth E Warner","doi":"10.1093/ntr/ntag099","DOIUrl":"https://doi.org/10.1093/ntr/ntag099","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society for Research on Nicotine and Tobacco Europe Debate: The case for countries adopting a policy of reducing nicotine content of cigarettes and other smoked products to minimal levels.","authors":"Irina Stepanov, Robert West","doi":"10.1093/ntr/ntag100","DOIUrl":"https://doi.org/10.1093/ntr/ntag100","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pre-Pregnancy Menthol Cigarette Use on Smoking Cessation Across Pregnancy and Postpartum: A Longitudinal Analysis of the Population Assessment of Tobacco and Health (PATH) Study.","authors":"Eva Sharma, Jessica M Powers, Sarah Maloney, Laura R Stroud","doi":"10.1093/ntr/ntag089","DOIUrl":"https://doi.org/10.1093/ntr/ntag089","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to characterize smoking cessation at pregnancy and postpartum return to use as a function of pre-pregnancy menthol vs. non-menthol cigarette use.</p><p><strong>Methods: </strong>Data were drawn from Waves 1-5 (2013-2019) of the Population Assessment of Tobacco and Health (PATH) Study, using three longitudinal time-points indicating pre-pregnancy, pregnancy, and postpartum in 179 participants who reported exclusive cigarette smoking at pre-pregnancy and were currently pregnant during the middle interval. Outcomes included (1) quit attempts and successful quitting within 12 months of pregnancy change in past 30-day smoking frequency at pregnancy, and postpartum return to use. Generalized estimating equations were conducted adjusting for sociodemographic and smoking characteristics.</p><p><strong>Results: </strong>Approximately 47% of pregnant persons who smoked reported use of menthol cigarettes at pre-pregnancy, almost 80% attempted to quit/cut down during pregnancy, and 43.6% successfully quit. Approximately 56% of those who reported being quit at pregnancy returned to use in postpartum. Menthol use was associated with smoking on 1.13 fewer days among those who continued to smoke at pregnancy. Although pre-pregnancy menthol cigarette use was associated with greater nicotine dependence (fewer minutes to first cigarette; p < .05), menthol cigarette use was not significantly associated with quit attempts, successful cessation or changes in smoking frequency at pregnancy, or postpartum return to use (ps > .05).</p><p><strong>Conclusions: </strong>Our study did not find an impact of pre-pregnancy menthol cigarette use on quit attempts, cessation, or postpartum return to use. Findings suggest cessation efforts should focus on behavioral and contextual factors beyond cigarette mentholation alone.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society for Research on Nicotine and Tobacco Europe Debate: Is mandated reduction of nicotine in tobacco the logical next step or an unworkable policy?","authors":"Daniel Kotz","doi":"10.1093/ntr/ntag098","DOIUrl":"https://doi.org/10.1093/ntr/ntag098","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-frequency rTMS in combination with nicotine replacement therapy for smoking cessation: a phase II non-comparative Fleming-type randomized, double-blind, sham-controlled trial.","authors":"Anastasia Demina, Benjamin Petit, Agnès Soudry-Faure, Karine Goueslard, Benoit Trojak","doi":"10.1093/ntr/ntag097","DOIUrl":"https://doi.org/10.1093/ntr/ntag097","url":null,"abstract":"<p><strong>Introduction: </strong>Innovative interventions such as repetitive transcranial magnetic stimulation (rTMS) may hold promise for individuals seeking smoking cessation support. In this Phase II pilot trial, we explored the potential of low-frequency rTMS (1 Hz) combined with nicotine replacement therapy to contribute to sustained tobacco abstinence.</p><p><strong>Methods: </strong>A non-comparative single-step Fleming-type Phase II randomized, double-blind, sham-controlled design was used to test the eligibility of active rTMS for a Phase III trial. The primary outcome was biochemically confirmed Continuous Abstinence Rate (CAR) at six weeks post-randomization in the active rTMS group. Secondary outcomes included 12-week and 12-month CAR, craving, mood and safety evaluations in both groups.</p><p><strong>Results: </strong>78 participants were randomized to the active (n=39) or sham rTMS group (n=39). All participants received nicotine replacement therapy. In the active rTMS group, at 6-week follow-up, 16 patients (41%) were abstinent versus 18 patients (46%) in the sham rTMS group. At the 12-week and 12-month follow-up assessments, abstinence rates declined in both groups, with 26% and 15% of participants maintaining abstinence in the active rTMS group, compared with 15% and 10% in the sham group, respectively. Craving scores decreased in both groups, and mood scores were equally distributed. Eleven mild-to-moderate adverse events were reported in the active group versus twenty-three in the sham group.</p><p><strong>Conclusion: </strong>Given our definition of treatment efficacy, active low-frequency rTMS can be considered effective and eligible for a phase III trial. However, this result requires careful consideration since the sham rTMS group exhibited similar outcomes. The remaining uncertainty suggests a need for further research, particularly to assess nicotine's influence on cortical excitability.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Substance Exposure and Early Childhood Adversity: Implications for Child Autonomic Functioning at Early School-Age.","authors":"Madison R Kelm, Olivia Bell, Pamela Schuetze, Rachel C Marcus, Kristin J Perry, Rina D Eiden","doi":"10.1093/ntr/ntag088","DOIUrl":"https://doi.org/10.1093/ntr/ntag088","url":null,"abstract":"<p><strong>Introduction: </strong>We examined associations between prenatal tobacco exposure (controlling for other substance exposures) and autonomic functioning at early school-age via infancy autonomic regulation, harsh parenting, and cumulative postnatal adversities.</p><p><strong>Methods: </strong>216 mothers (74% Black/African-American) and infants (51% girls) recruited at delivery were assessed repeatedly. Prenatal substance exposure was measured using multiple biomarkers and calendar-based interviews. Harsh parenting and early childhood adversity were assessed from birth to early school-age. Child ANS functioning was indexed via respiratory sinus arrhythmia (RSA) and skin conductance (SCL) at early school-age (both at rest and reactivity to frustration).</p><p><strong>Results: </strong>Prenatal tobacco and cannabis exposure accounted for unique variance in higher baseline SCL and RSA, respectively. Prenatal tobacco exposure was also indirectly associated with lower baseline SCL and blunted SCL reactivity via increased early childhood adversity. There was stability in baseline RSA from infancy to early school-age with prenatal cocaine exposure and prenatal cannabis exposure associated with lower baseline RSA in infancy. Prenatal cocaine exposure was also associated with higher baseline SCL and higher SCL reactivity via more harsh parenting.</p><p><strong>Conclusions: </strong>Findings highlight unique direct and indirect effects of prenatal tobacco exposure on child ANS functioning at early school-age, controlling for exposure to other substances and co-occurring risks. Results underscore the importance of smoking cessation interventions in pregnancy that address prenatal polysubstance use.</p><p><strong>Implications: </strong>The present study adds to the sparse literature on effects of prenatal tobacco exposure on autonomic nervous system functioning controlling for other substance exposure and co-occurring postnatal risks in a prospective design. Findings highlight the importance of smoking cessation treatments for pregnant individuals who use other substances in addition to tobacco. Furthermore, universal parenting interventions may promote positive outcomes even in the context of substance use. Efforts to address parents' mental health and provide parental support in the context of substance use may be of great benefit to families.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive withdrawal-related reward deficits after nicotine self-administration in rats.","authors":"Ranjithkumar Chellian, Azin Behnood-Rod, Adriaan W Bruijnzeel","doi":"10.1093/ntr/ntag096","DOIUrl":"https://doi.org/10.1093/ntr/ntag096","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco use disorder is a chronic relapsing condition characterized by withdrawal symptoms following smoking cessation. Smoking cessation leads to anhedonia, which is a reduced ability to experience pleasure that contributes to relapse. To investigate the time course of withdrawal-related changes in reward function, we used intracranial self-stimulation (ICSS) to assess brain reward thresholds in rats during abstinence between intermittent long-access nicotine self-administration sessions.</p><p><strong>Methods: </strong>Rats were implanted with ICSS electrodes to assess reward function and intravenous catheters for nicotine self-administration. Elevations in brain reward thresholds reflect decreased sensitivity to rewarding electrical stimuli, a preclinical measure of anhedonia-like behavior. Male rats self-administered 0.06 mg/kg of nicotine intermittently (three days per week, 23 h/day) for seven weeks. Brain reward thresholds were assessed at multiple time points between self-administration sessions during weeks 1-7.</p><p><strong>Results: </strong>Elevations in thresholds were not observed during the first four weeks of nicotine self-administration. However, the brain reward thresholds were elevated in weeks 5 and 7, at least 12 h after nicotine self-administration, indicating progressive development of withdrawal-related alterations in reward function. The nicotinic receptor antagonist mecamylamine precipitated similar threshold elevations, supporting the development of nicotine dependence-related neuroadaptations.</p><p><strong>Conclusions: </strong>These findings indicate that changes in reward function consistent with anhedonia emerge gradually during the course of nicotine self-administration. Therefore, early behavioral or pharmacological interventions may help prevent the development of withdrawal-related anhedonia and reduce the risk of tobacco use disorder.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of nicotine vape products (E-cigarettes) as a smoking cessation aid for US adults: a narrative review of findings from the population assessment of tobacco and health study.","authors":"Shu Xu, Jianan Zhu, Yuxin Zhang, Jennifer Hill, Yang Feng, David Abrams, Raymond S Niaura","doi":"10.1093/ntr/ntag068","DOIUrl":"https://doi.org/10.1093/ntr/ntag068","url":null,"abstract":"<p><strong>Introduction: </strong>Controversy remains regarding whether nicotine vaping products (NVPs) are associated with cigarette cessation in observational research. Reviews have largely overlooked studies using the same data source. To address this gap, we conducted a narrative review to examine the heterogeneity in the reported association that used data from the same source, which may help to explain inconsistent findings.</p><p><strong>Methods: </strong>We identified empirical studies through PubMed and Google searches that exclusively used the Population Assessment of Tobacco and Health (PATH) Study data to examine associations between NVP use and smoking cessation among adults. Adapting Arksey and O'Malley's approach, we extracted and summarized key study characteristics, including inclusion criteria, participant characteristics, study durations, definitions of NPV exposure and smoking outcomes, covariate adjustment, and analytic methods. We also conducted regression and regression tree analyses to examine how these characteristics were related to study findings.</p><p><strong>Results: </strong>We identified 28 articles comprising 38 analyses of NVP use and cigarette cessation. Of these, 24 studies (63.2%) reported a positive association, concluding that NVP use predicted cessation. Substantial heterogeneity existed across study characteristics. Evidence suggests that daily NVP use may promote cessation, whereas studies restricted to participants with an intention to quit were less likely to observe cessation than those including participants regardless of quit intention.</p><p><strong>Conclusions: </strong>Researchers are advised against making broad claims based on any single PATH Study analysis of NVP use and smoking cessation. Rather, multiple studies using the same data source must be carefully examined in order to synthesize evidence and assess consistency of the findings.</p><p><strong>Implications: </strong>Whether NVPs help adult smokers quit remains controversial in observational research, partly due to heterogeneity in study characteristics across studies using the same data source. Our review of observational studies based exclusively on a single data source-an approach often overlooked-suggests that (1) daily NVP use may support smoking cessation, and (2) studies that restricted participants to those with an intention to quit were less likely to observe cessation than studies that included participants regardless of quit intention. These findings underscore the value of multiple analyses using the same data source to synthesize evidence and assess consistency.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescents' perceptions of roll-your-own tobacco: A focus group study in Argentina.","authors":"María Belén Arnaudo, Emilia Elicabe, Raúl Mejía, Crawford Moodie, Isabelle Uny","doi":"10.1093/ntr/ntag094","DOIUrl":"https://doi.org/10.1093/ntr/ntag094","url":null,"abstract":"<p><strong>Introduction: </strong>Roll-your-own (RYO) tobacco sales are increasing in Latin America, with the product widely available in Argentina. We are not aware of any research in Latin America exploring adolescents' perceptions of RYO tobacco, or any research exploring how adolescents view RYO packaging and accessories.</p><p><strong>Methods: </strong>We conducted eight focus groups (n=51) in four cities in Argentina (Córdoba, Quilmes, San Salvador de Jujuy, Santa Rosa), with participants stratified by gender, age (13-14, 15-17) and smoking susceptibility (susceptible, non-susceptible). Participants were asked about RYO, RYO packaging and accessories.</p><p><strong>Results: </strong>Participants were aware of RYO tobacco. Many had seen hand-rolled cigarettes but often associated them with marijuana joints. RYO pack colours, materials, and descriptors influenced appeal and harm perceptions, as did flavours. Packs with descriptors such as 'natural' or 'additive-free' were considered more appealing and less harmful. Some believed, based on the packaging and from listening to relatives, that RYO was less harmful than factory-made cigarettes due to the absence of additives. The general view was that the act of rolling may reduce the urge to smoke, as it requires additional effort, but that this effect would likely diminish once people became accustomed to it. Some participants suggested that it would be easier to lose track of the amount smoked when using RYO. Accessories were seen as appealing and compared to candy.</p><p><strong>Conclusions: </strong>Adolescents are familiar with RYO tobacco, with perceptions of harm and appeal influenced by packaging, flavour and social narratives. Like many adult RYO smokers, some participants viewed RYO as less harmful than factory-made cigarettes.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}