Nicotine & Tobacco Research最新文献

{"title":"Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adult Rats with a Human Polymorphism (rs2304297) in the 3'-UTR of the CHRNA6 Gene.","authors":"Emily M Castro, Michelle T Nguyen, David Hany Georgy, Shahrdad Lotfipour","doi":"10.1093/ntr/ntaf147","DOIUrl":"https://doi.org/10.1093/ntr/ntaf147","url":null,"abstract":"<p><strong>Introduction: </strong>The widespread use of nicotine across ages culminates in substantial consequences on individual health, public health, and broader socioeconomic strain. Concerningly, adolescence is a uniquely vulnerable stage in which exploratory drug exposure imposes detrimental effects on reward circuitry, cognitive function, and neurochemical processes. A single nucleotide polymorphism (SNP), rs2304297, in the 3'-untranslated region (UTR) of the CHRNA6 gene has been linked to increased nicotine use in humans. To investigate the impact of this SNP, we engineered a humanized rat line and have demonstrated sex and genotype dependent effects on nicotine-induced behaviors in adolescent rats. Prior work identified neurochemical differences in the nucleus accumbens in both drug-naïve and nicotine treated humanized adolescent rats.</p><p><strong>Methods: </strong>In this study, we aim to determine how four days of nicotine pretreatment (2 x 30 μg/kg nicotine, i.v.) impacts behavior and dopamine-related protein expression in the critical ventral tegmental area and nucleus accumbens in female and male adolescent and adult human CHRNA6 3'-UTR SNP rats.</p><p><strong>Results: </strong>We show that nicotine enhances locomotor activity in adolescent female α6CC rats and male α6GG rats, while only enhancing locomotor activity in adult female α6CC rats. We found higher tyrosine hydroxylase (dopamine synthesis marker) levels in the ventral tegmental area of adolescent male α6GG rats compared to male α6CC rats independent of drug exposure.</p><p><strong>Conclusions: </strong>These findings demonstrate age differences in the sex and genotype dependent effects of the human CHRNA6 3'-UTR SNP in nicotine-induced behavior and provide novel evidence for genotype dependent differences in protein expression.</p><p><strong>Implications: </strong>The present study highlights novel genetic influences on nicotine-induced behavior that have unique age and sex differences.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in noticing and responding to, health warning labels on cigarette packages among adults who smoke: Findings from the ITC Four Country Surveys between 2002 and 2022.","authors":"Bibha Dhungel, Ron Borland, Hua-Hie Yong, Coral Gartner, Katherine A East, David Hammond, K Michael Cummings, Andrew Hyland, Maansi Bansal-Travers, Ann McNeill, Shannon Gravely, Geoffrey T Fong","doi":"10.1093/ntr/ntaf156","DOIUrl":"https://doi.org/10.1093/ntr/ntaf156","url":null,"abstract":"<p><strong>Introduction: </strong>We present data on 20-year (2002-2022) trends in reactions of smokers to Health Warning Label (HWL) changes (e.g., increasing warning size, requiring graphic images, mandating standardized packaging) in Canada, England, and Australia, compared to the US where HWLs did not change.</p><p><strong>Methods: </strong>We analyzed weighted data from 16 waves of the International Tobacco Control Four Country Survey, comprising 99 438 observations from 49 034 adults (ages 18+) who smoked cigarettes (daily or non-daily), tracking indicators of HWL effectiveness including noticing HWLs and related thoughts about harms from smoking and quitting.</p><p><strong>Results: </strong>The first HWL change studied in each country (Canada-2001; England-2003; Australia-2006) had the largest impact on all indicators of HWL effectiveness; subsequent changes in all three countries had less or no additional impact. Over 20 years, noticing and quitting thoughts (for daily smoking) decreased significantly in the US. In the last three waves (2018-2022), noticing remained lowest in the US. Thinking about harm and quitting were lower in the US than in Canada and England, but in Australia, levels of \"Thinking about harms\" were significantly lower than in the US. People smoking non-daily maintained higher levels on some key measures than those smoking daily.</p><p><strong>Conclusions: </strong>In countries with long histories of public education about smoking harms, periodically strengthening HWLs on cigarette packs appears to have diminishing impacts on smokers' reactions with long-term impacts of strong warnings small, especially for people smoking daily. The findings suggest short-term impacts of HWLs relate to the change from previous HWLs and not their absolute magnitude.</p><p><strong>Implications: </strong>HWLs on cigarette packs remain important for discouraging smoking, but the effects of strengthening warnings on smokers' reactions decline with time and are smaller where HWLs were already strong. Sustained effects may be greater for non-daily smokers. Countries with weak or no HWLs may benefit in the medium term from stronger HWLs, though returns diminish as HWL coverage increases. Future smoking models should not assume long-term large cessation effects from stronger HWLs as they can do in the short term but allow for a range of smaller impacts. This study did not assess HWLs' impact in preventing uptake.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"College Students' Awareness of California's Law Prohibiting Sales of Flavored Tobacco.","authors":"Nora Satybaldiyeva, Nina C Schleicher, Trent Johnson, Arzoo Alam, Judith J Prochaska, Lisa Henriksen","doi":"10.1093/ntr/ntaf160","DOIUrl":"https://doi.org/10.1093/ntr/ntaf160","url":null,"abstract":"<p><strong>Introduction: </strong>Laws prohibiting sales of flavored tobacco are increasingly prevalent across the US, with eight states and 402 localities passing such laws between 2010 and 2024. California's statewide law prohibiting sales of flavored tobacco products went into effect on December 21, 2022. It is unknown whether California college students are aware of this law.</p><p><strong>Methods: </strong>An online survey of California college students (ages 18-24) was conducted April 4-August 6, 2024 (n=3,919). Mixed models estimated associations between awareness of the state law and any tobacco product use (including nicotine vapes, cigarettes, cigars, hookah, and nicotine pouches), adjusting for sociodemographic characteristics.</p><p><strong>Results: </strong>Overall, only 20.8% of students were aware of the state law. Awareness differed by any tobacco use: 16.1% among never, 23.3% ever (not current), and 24.4% current. Compared to students who never used tobacco, students who reported ever using were more likely to be aware (aOR=1.50, 95% CI: 1.19, 1.90), as were those who reported current use (aOR=1.53, 95% CI: 1.24, 1.87). Among students who reported current use, those who used flavored tobacco were less likely to be aware compared to those who used unflavored tobacco (23.3% vs. 31.6%; aOR=0.59, 95% CI: 0.42, 0.83).</p><p><strong>Conclusions: </strong>More than 15 months after California prohibited flavored tobacco sales, only one in five college students was aware of the law. Surprisingly, awareness was lower among students who used flavored tobacco than those who used unflavored tobacco. Students who use unflavored tobacco may have greater awareness as a result of challenges with purchasing flavored tobacco.</p><p><strong>Implications: </strong>This is the first study to examine awareness of California's law prohibiting sales of flavored tobacco among young adults (ages 18-24). Only 20.8% of California college students were aware of the law. Notably, awareness was lower among students who reported current use of flavored tobacco compared to those who reported current use of unflavored tobacco. Some students may have faced difficulties purchasing flavored tobacco, which raised their awareness of the law. These results suggest the need for public health campaigns and retail signage to improve awareness of the law, particularly among young adults.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community Perceptions of Flavor Restriction Policies: A Scoping Review of Disaggregated Outcomes.","authors":"Tong Lin, Jill M Singer, Megan E Roberts","doi":"10.1093/ntr/ntaf157","DOIUrl":"https://doi.org/10.1093/ntr/ntaf157","url":null,"abstract":"<p><strong>Introduction: </strong>Increasingly, U.S. states and localities are passing policies to restrict menthol and other characterizing flavors in tobacco products. Given the disproportionate use of flavored tobacco among historically marginalized groups, such restrictions have the potential to promote health equity. This scoping review aimed to characterize community perceptions of flavor restrictions using an equity lens.</p><p><strong>Methods: </strong>We conducted a PubMed search for U.S.-based studies that reported on flavor restriction outcomes, disaggregated by race, ethnicity, or LGBTQ identity.</p><p><strong>Results: </strong>Across the 22 studies identified, two foci emerged: factors influencing the passage of flavor restrictions (e.g., policy support) and the impacts of implementing these restrictions (e.g., cessation intentions). Support for flavor restrictions varied by product and population: menthol cigarette restrictions received notably higher support among African American and Hispanic communities, while evidence for e-cigarette flavor restrictions was mixed-some studies reported minimal subgroup differences, whereas others reported higher support among specific racial/ethnic groups. A few studies discussed unintended consequences, such as product substitution or engagement with illicit channels; these studies were also mixed regarding which racial/ethnic groups would be most impacted. Key research gaps included long-term behavioral outcomes and outcomes across LGBTQ identities.</p><p><strong>Conclusions: </strong>While there are clear racial/ethnic differences for support of menthol cigarette bans, much of the literature on other types of flavor restrictions is mixed. Further research is needed to resolve these discrepancies and expand beyond race and ethnicity when disaggregating subgroups. Such efforts are critical to ensuring flavor restrictions achieve their intended public health benefits and advance health equity.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine and Tobacco Research Related to Sex/Gender: A 10-Year Update.","authors":"Elise E DeVito, Alicia M Allen, Andrea H Weinberger","doi":"10.1093/ntr/ntaf154","DOIUrl":"https://doi.org/10.1093/ntr/ntaf154","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biased Reaction and Higher Cortical Coherence Under Smoking Cue in Young Smokers.","authors":"Yiming Lu, Fang Dong, Juan Wang, Yanhong Xu, Yuxin Ma, Yongxin Cheng, Youwei Dong, Zhiwei Ren, Kai Yuan, Dahua Yu","doi":"10.1093/ntr/ntaf088","DOIUrl":"https://doi.org/10.1093/ntr/ntaf088","url":null,"abstract":"<p><strong>Introduction: </strong>Nicotine addiction is a widespread problem globally, causing millions of deaths and illnesses every year. People who start smoking at a young age are more likely to become addicted to nicotine. The cue-induced craving paradigm is used to study the nervous system related to nicotine dependence. The purpose of this study is to compare the coherence changes in functional connectivity in response to smoking stimuli between smokers and non-smokers.</p><p><strong>Methods: </strong>We recruited 32 young smokers and age-matched non-smokers. We calculated the inter-hemispheric and intra-hemispheric coherences under smoking stimuli and neutral stimuli for both groups and conducted correlation analyses with relevant scales.</p><p><strong>Results: </strong>Under smoking cue reactivity, compared with non-smokers, young smokers showed stronger inter-hemispheric delta coherence in the frontal region. In both the left and right hemispheres, smokers showed stronger intra-hemispheric delta coherence. Compared with neutral stimuli, smokers had stronger inter-hemispheric delta coherence in the frontal and central regions. In the left hemisphere, the intra-hemispheric delta coherence between frontal-central and frontal-occipital was stronger. In the right hemisphere, the delta and theta coherence across frontal-central region was stronger. Moreover, in young smokers, there was a significant correlation between frontal coherence and pack-year, as well as craving change under cue-induced stimuli.</p><p><strong>Conclusions: </strong>Nicotine may damage the coherence of the brains of young smokers, which may lead to impaired cognitive function, reduced decision-making ability, and a strong memory response to addiction-related cues.</p><p><strong>Implications: </strong>The enhanced brain coherence of young smokers under smoking stimuli and its relationship with smoking intensity and craving changes may represent a reduction in cortical efficiency and cognitive processing biases. And due to the attentional bias mechanism, smokers will allocate more resources to smoking stimuli and have a stronger craving.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the use of vaping products and other smoking cessation methods among adults who attempt to stop smoking: Findings from ITC Four Country Smoking and Vaping Surveys (2016-2020).","authors":"Kimberly D'Mello, Pete Driezen, Katherine A East, Geoffrey T Fong, David Hammond","doi":"10.1093/ntr/ntaf152","DOIUrl":"https://doi.org/10.1093/ntr/ntaf152","url":null,"abstract":"<p><strong>Introduction: </strong>E-cigarettes are an increasingly popular method of smoking cessation assistance; however, there is little research on whether this has affected the number of smokers who quit using \"any\" evidence-based cessation aid. This study examined trends in the use of cessation aids, including e-cigarettes and other evidence-based methods.</p><p><strong>Methods: </strong>Data are cross-sectional surveys in 2016, 2018, and 2020 from the ITC Four Country Smoking and Vaping Survey conducted in Canada, United States (US), England, and Australia. Respondents were adults (≥18) recruited by commercial panel firms who currently smoked, and/or quit smoking in the past 12-months. Respondents were asked about use of e-cigarettes, nicotine replacement therapies (NRT), prescription medications, quitlines, and counseling services during their last quit attempt (LQA). GEE regression models analyzed separately by country examined use of cessation assistance among 14 536 observations (Canada = 4880; US = 2917; England = 4846; Australia = 1898).</p><p><strong>Results: </strong>E-cigarettes (29.9%) and NRT (29.8%) were popular methods of cessation assistance at LQA. Using e-cigarettes at LQA increased in Australia (2016 = 11.1%; 2020 = 25.1%; p=.002) and England (2016 = 37.1%; 2018 = 46.7%; p=.002), with no significant change in Canada or the US. Across all countries, there was little change over time in the overall use of evidence-based cessation assistance. Nearly half of respondents used some form of cessation assistance excluding e-cigarettes. Approximately two-thirds used \"any\" form of evidence-based cessation including e-cigarettes at LQA, which decreased in Canada (2016 = 64.0%, 2020 = 58.9%; p=.010).</p><p><strong>Conclusion: </strong>While e-cigarettes are a popular cessation aid, use of other evidence-based cessation assistance has remained comparatively stable among adults that tried to quit smoking.</p><p><strong>Implications: </strong>The findings indicated that e-cigarettes are a popular cessation method among adults trying to quit smoking. Despite differences in e-cigarette use and regulatory environments in the four countries, rates of evidence-based cessation assistance were similar across countries and over time. E-cigarettes can be an effective method for stopping smoking; however, the current study suggests few, if any, changes in the proportion of adults who smoke using any evidence-based form of cessation assistance, despite changes in the use of e-cigarettes as a quit aid.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The world conference on tobacco control - mixed perspectives and controversies.","authors":"Cailtin Notley","doi":"10.1093/ntr/ntaf146","DOIUrl":"https://doi.org/10.1093/ntr/ntaf146","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Effects of Economic Growth and Unemployment on Tobacco Use: A Panel Data Approach.","authors":"Yunus Savaş, Veysel Erat, Dilek Alma Savaş","doi":"10.1093/ntr/ntae244","DOIUrl":"10.1093/ntr/ntae244","url":null,"abstract":"<p><strong>Introduction: </strong>The economic situation is recognized as a significant factor influencing tobacco consumption. Accordingly, this research aims to investigate the relationship between economic growth, unemployment, and tobacco use.</p><p><strong>Methods: </strong>This investigation employs data from 1985 to 2019 to elucidate the relationship between economic growth, unemployment, and tobacco consumption in a select group of Organization for Economic Co-operation and Development countries. Employing Pedroni and Johansen-Fisher panel co-integration tests, we assess the co-integrating relationships. Furthermore, FMOLS and DOLS techniques are applied, complemented by the Dumitrescu-Hurlin panel causality test.</p><p><strong>Results: </strong>FMOLS and DOLS results suggest that a 1% increase in gross domestic product (GDP) leads to a 6.46% and 7.29% rise in tobacco consumption, respectively, while GDP squared results in a 0.39% and 0.43% decrease. However, both tests failed to establish a significant relationship between tobacco consumption and unemployment. Co-integration was confirmed by Johansen-Fisher and Pedroni tests. Dumitrescu-Hurlin causality tests revealed the direction of Granger causality from economic growth to tobacco consumption, but not with unemployment.</p><p><strong>Conclusion: </strong>Tobacco consumption declined across all countries studied. Economic growth shows a positive association, while GDP squared has a negative association, indicating an inverted U-shaped relationship. No significant relationship was found with unemployment in the employed tests.</p><p><strong>Implications: </strong>In addition to the measures implemented by countries to reduce tobacco consumption, economic factors also exert a significant relation with smoking behavior. The available results suggest that economic growth is initially associated with an increase in tobacco consumption but the reduction in later stages indicating a long-term inverse relationship between economic growth and tobacco use.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1376-1384"},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Media Engagement and Quit Intentions Among Youth With Exclusive E-cigarette Use: The Moderating Role of Social Norms.","authors":"Rime Jebai, Traci Hong, Lynsie R Ranker, Jiaxi Wu, Aarushi Rohila, Jessica L Fetterman, Jennifer Cornacchione Ross","doi":"10.1093/ntr/ntaf031","DOIUrl":"10.1093/ntr/ntaf031","url":null,"abstract":"<p><strong>Introduction: </strong>E-cigarette use is prevalent among US youth. Little is known about the association between engagement with e-cigarette-related social media posts, vaping norms, and intention to quit e-cigarettes among youth who exclusively use e-cigarettes.</p><p><strong>Methods: </strong>A cross-sectional national online survey was conducted among a sample of youth aged 13-18 who reported exclusive e-cigarette use in the past 30 days. Logistic regression was used to estimate the association between engagement with e-cigarette-related posts on social media, vaping social norms, and intention to quit e-cigarettes. Two interaction terms were added between descriptive and injunctive norm variables and engagement with social media posts, respectively, to test the potential differential effect of social norms on intention to quit. Models were adjusted for demographic and e-cigarette use variables.</p><p><strong>Results: </strong>The sample (N = 143) was 62% females; 69% identified as White and 20% as Black. Engaging with e-cigarette-related posts on social media was associated with higher odds of an intention to quit e-cigarettes compared to those who never engaged with e-cigarette posts [adjusted aOR = 2.70, 95%CI (1.13,6.42)]. Intention to quit e-cigarettes was lower among youth who believed the use of e-cigarettes was common (descriptive norms) [0.71, (0.57,0.88)], and who described the views of people important to them as positive (vs. negative; injunctive norms) [0.26, (0.07,0.98)]. Youth who engaged with posts and had positive views from people important to them on e-cigarettes (injunctive norms) were less likely to express an intent to quit vaping (aOR = 0.10; p-value = .0394).</p><p><strong>Conclusions: </strong>Social media exposure and social norms may influence quit intentions among youth who exclusively use e-cigarettes. Targeted interventions on social media to address the potential of these factors in promoting cessation behaviors are needed.</p><p><strong>Implications: </strong>Our study highlights the interplay between social media engagement, descriptive and injunctive social norms of vaping, and intention to quit e-cigarette use among youth who exclusively use e-cigarettes. These insights are crucial for designing effective, targeted social media-based cessation interventions, promoting quitting intentions, and addressing misperceptions about vaping, thereby supporting youth cessation behaviors.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1438-1446"},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}