Nicotine & Tobacco Research最新文献

{"title":"Determining composition and distribution of nicotinic acetylcholine receptors in mouse ventral tegmental area brain region with single-cell sequencing approach.","authors":"Jingmin He, Meidi Zhang, Pei Zhao, Yan Wang, Qiaoning Chang, Guoliang Chen, Zhongli Yang, Ming D Li","doi":"10.1093/ntr/ntaf075","DOIUrl":"https://doi.org/10.1093/ntr/ntaf075","url":null,"abstract":"<p><strong>Introduction: </strong>Nicotine affects on the central and peripheral neuron systems by interacting with nicotinic acetylcholine receptors (nAChRs). However, the distribution and composition of these nAChR subunits at single-cell level within ventral tegmental area (VTA) remain unclear.</p><p><strong>Methods: </strong>Single-cell nuclear suspension was prepared and sequenced from the VTA of nicotine-treated and saline-control C57BL/6 mice. Sequencing data were subjected to quality control and followed by cell type determination. The combination probability of nAChR subunits and acetylcholine metabolism products were estimated with Metacell and single cell Flux Estimation Analysis (scFEA), respectively. The relationships between gene modules and nAChRs were established using high-dimensional weighted gene co-expression network analysis (hdWGCNA).</p><p><strong>Results: </strong>Sequencing of 53,855 VTA cells from six mice identified eight cell types, with the strongest communication observed between neurons and other cell types. Neuron subtypes included dopamine (DA), gamma-aminobutyric acid (GABA), glutamate (GLU), and GABAergic neurons with glutamate characteristics (GABA+GLU). The co-expression probability of nAChR subunits were determined for each neuron type. scFEA revealed nicotine treatment increased acetylcholine and DA metabolites but decreased phosphatidylcholine. hdWGCNA revealed five modules were significantly correlated with nicotine treatment, nAChR subunits, and DA neurons, indicating a potential role for nAChR subunits on DA neurons.</p><p><strong>Conclusions: </strong>This study not only revealed differences in the expression of each nAChR subunit but also determined their composition and distribution at the single-neuron level within the VTA region.</p><p><strong>Implications: </strong>This study not only determined which subunit gene is expressed in which type of neuron, but also predicted potential combinations of different nAChR subunits for different neurons. Such information is critical and useful for researchers to understand the role of each nAChR subunit at the neuronal level.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The availability and marketing of nicotine pouches at tobacco-selling points-of-sale in Pakistan.","authors":"Midhat Farzeen, Crawford Moodie, Zohaib Khan, Sheraz Ahmad Khan, Saeed Ansari, Amina Khan, Kamran Siddiqi","doi":"10.1093/ntr/ntaf069","DOIUrl":"https://doi.org/10.1093/ntr/ntaf069","url":null,"abstract":"<p><strong>Introduction: </strong>Nicotine pouches are gaining popularity among young people. Within five years of their introduction, Pakistan has become the third-largest market for Velo, a leading brand among nicotine pouches. However, more information is needed to know about the availability and marketing of these products at point-of-sale (POS).</p><p><strong>Methods: </strong>In August 2023, we surveyed 711 POS across nine districts covering all four provinces of Pakistan. We collected data on the availability of different brands of nicotine pouches and their flavours, nicotine strengths, prices, and pack features. Furthermore, we recorded any POS advertising in a subsample of 382 POS.</p><p><strong>Results: </strong>In Pakistan, nicotine pouches were available in all four provinces, eight of nine surveyed districts, and 56 of 711 (7.9%) POS. Urban settings had wider availability and more variety than rural settings. Velo, available in six flavours and three different strengths, captured 85% of the market. On average, nicotine pouches cost 133 Pakistani Rupees (SD 18.9, range 100-190 PKR) or 0.44 US dollars. Display stands advertising nicotine pouches were observed in 12.3% (46/382) POS.</p><p><strong>Conclusions: </strong>Nicotine pouches are widely available across Pakistan. A range of flavours and strengths are being sold at an affordable price, making it attractive, particularly for young people. Continued surveillance of these products is needed. Their perceptions and use, and their impact on the tobacco uptake in youth, also need further research.</p><p><strong>Implications: </strong>We observed widespread availability of Velo and the growing nicotine pouch market in Pakistan, underscoring the urgent need for regulation. These products appeal to youth with diverse flavors and affordability, raising concerns about experimentation leading to addiction. Policymakers must prioritize regulating manufacturing, sales, and marketing to limit youth access. Limited research in Asia necessitates longitudinal studies to explore oral health impact of using these products. Continued monitoring of promotions at points of sale, along with studies on youth perceptions, usage patterns, and influence on tobacco uptake, is critical for effective policy development.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Appeal of Nicotine Pouch Packaging, Flavour and Nicotine Descriptors among Adults in the UK: An Online Experiment.","authors":"Eve Taylor, Madeleine Ebdon, Matilda Nottage, Erikas Simonavicius, Leonie Brose, Ann McNeill, Deborah Arnott, Hazel Cheeseman, Laura Bunce, Katherine East","doi":"10.1093/ntr/ntaf072","DOIUrl":"https://doi.org/10.1093/ntr/ntaf072","url":null,"abstract":"<p><strong>Introdcution: </strong>Nicotine pouches have the potential to be used for tobacco harm reduction. Pouches can currently be sold in brightly coloured packaging with conceptual flavour and nicotine descriptors, which may appeal to youth. Therefore, the UK government are considering packaging regulations. We examined the impact of standardised packaging, limiting flavour names and standardising nicotine descriptors on appeal and harm perceptions of nicotine pouches among adults.</p><p><strong>Methods: </strong>A 2024 Prolific Academic online experiment among UK Adults (N=2,967) was used. Participants were randomised to one of four packaging conditions: (1) branded, (2) standardised with usual descriptors, (3) standardised with limited flavour descriptors, and (4) standardised with limited flavour and standardised nicotine descriptors. Logistic regressions examined associations between packaging conditions and (a) no interest in trying the products displayed and (b) harm perceptions relative to cigarettes.</p><p><strong>Results: </strong>There were no significant differences in reporting no interest in trying nicotine pouches in branded compared to standardised packaging with usual descriptors, standardised packaging with limited flavour descriptors, and standardised packaging with limited flavour and nicotine descriptors. When stratified by vaping/smoking status, participants who currently vaped had lower odds of reporting no interest in standardised packaging with limited flavour descriptors, compared to branded. There were no significant differences in harm perceptions by packaging condition.</p><p><strong>Conclusions: </strong>Overall, standardising packaging, limiting flavour descriptors, and standardising nicotine descriptors had little effect on adults' interest in trying nicotine pouches or their perceptions of relative harm. There were, however, some differences by vaping status.</p><p><strong>Implications: </strong>Findings suggest that if a standardised packaging, flavour and nicotine descriptors policy is introduced for nicotine pouches to deter youth use, there might be little impact on appeal or harm perceptions among adults. This is important because nicotine pouches could be a helpful part of the toolkit for tobacco harm reduction.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Harm Visibility for Pictorial Health Warning Labels on Cigars.","authors":"Sonia A Clark, Sarah D Kowitt, Kristen L Jarman, Allison J Lazard, Tara L Queen, Leah M Ranney, Jennifer Cornacchione Ross, Paschal Sheeran, James F Thrasher, Adam O Goldstein","doi":"10.1093/ntr/ntae113","DOIUrl":"10.1093/ntr/ntae113","url":null,"abstract":"<p><strong>Introduction: </strong>Pictorial health warning labels (HWLs) can communicate the harms of tobacco product use, yet little research exists for cigars. We sought to identify the most effective types of images to pair with newly developed cigar HWLs.</p><p><strong>Aims and methods: </strong>In September 2021, we conducted an online survey experiment with US adults who reported using little cigars, cigarillos, or large cigars in the past 30 days (n = 753). After developing nine statements about health effects of cigar use, we randomized participants to view one of three levels of harm visibility paired with each statement, either: (1) an image depicting internal harm not visible outside the body, (2) an image depicting external harm visible outside of the body, or (3) two images depicting both internal and external harm. After viewing each image, participants answered questions on perceived message effectiveness (PME), negative affect, and visual-verbal redundancy (VVR). We used linear mixed models to examine the effect of harm visibility on each outcome, controlling for warning statement.</p><p><strong>Results: </strong>Warnings with both and external harm depictions performed significantly better than the internal harm depictions across all outcomes, including PME (B = 0.21 and B = 0.17), negative affect (B = 0.26 and B = 0.25), and VVR (B = 0.24 and B = 0.17), respectively (all p < .001). Compared to both, the external depiction of harm did not significantly change PME or negative affect but did significantly lower VVR (B = -0.07, p = .01).</p><p><strong>Conclusions: </strong>Future cigar pictorial HWLs may benefit from including images depicting both or external harm depictions. Future research should examine harm visibility's effect for other tobacco pictorial HWLs.</p><p><strong>Implications: </strong>The cigar health warning labels (HWLs) proposed by the US Food and Drug Administration are text-only. We conducted an online survey experiment among people who use cigars to examine the effectiveness of warnings with images depicting different levels of harm visibility. We found HWLs with images depicting both an internal and external depiction of cigar harm, or an external depiction of harm alone, performed better overall than images portraying internal depictions of harm. These findings provide important regulatory evidence regarding what type of images may increase warning effectiveness and offer a promising route for future cigar HWL development.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"714-721"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic Cigarettes as a Recommended Smoking Cessation Tool During Pregnancy: We Are Not There Yet.","authors":"Pingsheng Wu, Hui Nian, Steven M Brunwasser","doi":"10.1093/ntr/ntae247","DOIUrl":"10.1093/ntr/ntae247","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"779-780"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking.","authors":"Deniz Bagdas, Nii A Addy","doi":"10.1093/ntr/ntae241","DOIUrl":"10.1093/ntr/ntae241","url":null,"abstract":"<p><strong>Introduction: </strong>The influence of early exposure to sweet and fruit flavors on subsequent nicotine use behaviors during adolescence remains poorly understood. To address this gap, we utilized a rodent model to simulate childhood flavor exposure and examine its effects on later nicotine use behaviors.</p><p><strong>Aims and methods: </strong>We employed a two-bottle choice paradigm in weanling rats to mimic human childhood flavor exposure. Subsequently, we investigated the impact of early exposure to sweet (saccharin) and cherry fruit (benzaldehyde) flavors on adolescent nicotine use behaviors. This included assessing subsequent nicotine acquisition, maintenance, and seeking behaviors using intraoral flavor and intravenous nicotine self-administration.</p><p><strong>Results: </strong>Our findings reveal that rats exposed to saccharin during early development exhibited altered patterns of nicotine intake and seeking behaviors during adolescence. Specifically, rats demonstrated increased nicotine intake and seeking of saccharin flavored solutions when paired with nicotine, indicating a potential predisposition towards nicotine use following childhood flavor exposure. Intraoral benzaldehyde did not affect nicotine reinforcement in early sessions of self-administration, but significantly decreased nicotine reinforcement during later sessions. Both saccharin exposure alone or in combination with benzaldehyde promoted nicotine reinforcement. No significant sex differences in nicotine-related behaviors were observed.</p><p><strong>Conclusions: </strong>This study highlights the significance of early flavor exposure in shaping adolescent nicotine use behaviors. The findings suggest that childhood exposure to sweet flavors may contribute to heightened susceptibility to nicotine use and addiction later in life. Understanding these early influences is crucial for developing targeted interventions to prevent the onset of nicotine addiction during adolescence.</p><p><strong>Implications: </strong>Our study highlights the importance of how sweetness can contribute to and possibly even alter the effects of the flavor itself. The sweetness of a tobacco product does not solely stem from sweeteners, but it is also influenced by other components such as the propylene glycol (PG) and vegetable glycerin (VG) ratio (eg, higher VG) and the inclusion of flavors associated with sweetness (eg, vanillin and ethyl maltol). Therefore, sweet-associated constituents in tobacco products should be investigated further to inform regulatory policy. We believe that our findings can inform regulatory decisions on controlling sweet-associated constituents in tobacco products.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"666-675"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine Toxicity From Repeat Use of Nicotine Pouches.","authors":"Jessica T Kent, Garrick Mok, Emily Austin","doi":"10.1093/ntr/ntae111","DOIUrl":"10.1093/ntr/ntae111","url":null,"abstract":"<p><strong>Background: </strong>Nicotine pouches have emerged as a novel way to administer concentrated nicotine and come as a white powder in flavored, microfiber pouches placed between the cheek and gums to dissolve without requiring spitting. While marketed as a safe alternative to smoking, nicotine pouches have the potential for toxic exposure to users.</p><p><strong>Case presentation: </strong>We present a case of a 21-year-old male with acute nicotine toxicity through repeated administration of nicotine pouches. Over the course of 12 hours, he consumed 15 extra-strength nicotine pouches (10.9 mg per pouch) as a study tool to prepare for the next-day exams. He presented to the emergency department with bizarre behavior requiring admission for persistent confusion and nausea which resolved after 24 hours.</p><p><strong>Conclusions: </strong>This case represents the first case of acute nicotine toxicity secondary to nicotine pouch use. These pouches are emerging as a novel way to use nicotine and present a serious risk of inadvertent overdose and harm.</p><p><strong>Implications: </strong>Nicotine pouches are emerging as a novel way to use nicotine, and second to e-cigarettes, are the most frequently used nicotine product among youth. These pouches, which lack clear warning labels, are promoted among social media forums and present a serious risk of inadvertent overdose and harm, especially among young adults. Healthcare professionals should be aware of this risk, especially from acute, repeated exposures, and should ensure the public is cautioned appropriately.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"767-768"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#Discreetshipping: Selling E-cigarettes on TikTok.","authors":"Page D Dobbs, Eric D Schisler, Charlotte McCormick","doi":"10.1093/ntr/ntae081","DOIUrl":"10.1093/ntr/ntae081","url":null,"abstract":"<p><strong>Introduction: </strong>Youth and young adult use of e-cigarette products continues to remain high despite regulatory approaches to reduce youth access. This study sought to examine TikTok content regarding the sale and distribution of e-cigarettes.</p><p><strong>Aims and methods: </strong>TikTok videos (n = 475) and metadata posted between June 2022 and August 2023 were scraped using a TikTok application programming interface and popular hashtags used to sell vaping products (ie, #discreetshipping [40.8 million], #puffbundle [14.8 million], #hiddennic [1.0 million]). After watching the 25 most viewed videos (39 600-868 800 views), a codebook was developed. All metadata were annotated using 11 unique codes: Small business, brand, cannabis, bundled, hidden, fake, international sales, no ID, order via Instagram, order via another method, and cost.</p><p><strong>Results: </strong>Overall, 367 videos (with an average of 2017 likes) were deemed relevant. Videos advertised popular vaping brands (50.4%) that included cannabis products (45%). Products were described as bundled (28.6%), hidden (8.7%), and able to be shipped internationally (6%) without age verification (45.2%). Some videos (8.2%) evaded algorithms' detection of illegal activity by describing the post as \"Fake.\" Customers were directed to other social media platforms (most often Instagram, 57.5%) and/or other websites/links (58.3%) to purchase products; 22.1% advertised discounts, free shipping, or low costs (ranging from $25-$35).</p><p><strong>Conclusions: </strong>Social media platforms, such as TikTok and Instagram, are being used to circumvent e-cigarette regulatory policies. Regulatory agencies should expand enforcement strategies to include social media platforms where users are illegally selling and distributing e-cigarettes internationally to young audiences.</p><p><strong>Implications: </strong>TikTok users across the globe are violating local, state, and federal laws by selling e-cigarettes concealed inside other products or bundled in packages that avoid detection. TikTok videos posted by self-proclaimed small business owners advertise discreet shipping practices that evade age verification in order to sell nicotine and cannabis bundles worldwide. Accounts used phrases describing the post to be \"fake\" to avoid detection by algorithms or TikTok administrators. E-cigarette regulatory agencies can partner with social media platforms to close regulatory gaps.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"748-752"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral Interventions for Tobacco Cessation in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.","authors":"Abhijit Nadkarni, Leena Gaikwad, Miriam Sequeira, Pranay Javeri, Deepthy Benoy, Marimilha Grace Pacheco, Richard Velleman, Pratima Murthy, Felix Naughton","doi":"10.1093/ntr/ntae259","DOIUrl":"10.1093/ntr/ntae259","url":null,"abstract":"<p><strong>Introduction: </strong>An estimated 78% of the total deaths attributable to smoking tobacco use occurred in low- and middle-income countries (LMICs) in 2019. In addition, smokeless tobacco increases the risk of all-cause mortality, all cancers, including upper aero-digestive tract cancer, stomach cancer, ischemic heart disease and stroke, with 88% of the mortality burden being borne by the South-East Asian region. Evidence-based interventions from high-income countries (HICs) are not easily transferable to LMICs, as patterns of tobacco use, health beliefs associated with tobacco use, and awareness of specific health risks vary substantially.</p><p><strong>Methods: </strong>We synthesized the effectiveness of behavioral interventions for tobacco cessation in LMICs through a systematic review and meta-analysis. Interventional studies which delivered individual behavioral intervention and assessed abstinence from tobacco use were included. We examined the pooled intervention effect at 6 months postintervention follow-up.</p><p><strong>Results: </strong>For continuous abstinence at 6 months, the intervention was superior to the active comparator (RR 2.32; 95% CI 1.78 to 3.02) and usual care (RR 4.39; 95% CI 2.38 to 8.11). For point prevalence abstinence at six months, the intervention was superior to the active comparator (RR 1.76; 95% CI 1.28 to 2.44), and usual care (RR 2.37; 95% CI 1.47 to 3.81). The statistical heterogeneity was substantial to considerable for all comparisons. Only six studies had an overall low risk of bias. Publication bias was observed for all comparisons except for 6-month continuous outcomes.</p><p><strong>Conclusions: </strong>Implementation research is needed to understand factors for programme sustainability and equity of the impact of behavioral interventions in reducing tobacco use in LMICs.</p><p><strong>Implications: </strong>Our review is an important step towards understanding the effectiveness of behavior interventions for tobacco cessation suited for LMICs and which are responsive to the contextual needs of such countries.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"575-585"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a National Longitudinal Tobacco Cohort of Youth and Young Adults: The Tobacco Epidemic Evaluation Network (TEEN+) Study.","authors":"Elizabeth L Seaman, Jennifer M Kreslake, Jamie Cordova, Barbara Schillo, Frances Barlas, Kristy Marynak","doi":"10.1093/ntr/ntae064","DOIUrl":"10.1093/ntr/ntae064","url":null,"abstract":"<p><strong>Introduction: </strong>Timely and relevant data are critical to monitoring the rapidly changing youth vaping epidemic and for understanding the prevalence, patterns of use, knowledge, and perceptions of tobacco products. While e-cigarettes have been the most used tobacco product among youth for nearly a decade, new nicotine delivery products continue to be introduced to the US market. Flavored tobacco products, including flavored e-cigarettes, menthol cigarettes, and flavored cigars, drive disparities in use by young people.</p><p><strong>Aims and methods: </strong>To examine tobacco use among youth and young adults, the Monitoring E-Cigarette Use among Youth project established a longitudinal cohort of youth and young adults (13-24)-the Tobacco Epidemic Evaluation Network (TEEN+) study. TEEN+ focuses on e-cigarette and other tobacco products use and also includes questions about other substance use (eg, marijuana, alcohol), physical health, mental health, and social determinants of health (eg, discrimination, poverty, sexual and gender identity). Geocoding of responses allows for the evaluation of local tobacco control policies. The cohort includes an oversample of California residents to generate reliable and representative state-level estimates. This manuscript provides an overview of methods and baseline demographics from Wave 1.</p><p><strong>Results: </strong>The initial Wave 1 TEEN+ cohort included 10 255 in the national sample and 2761 in the California sample.</p><p><strong>Conclusions: </strong>TEEN+ study data complement nationally-representative cross-sectional studies and allow for rapid evaluation of local and state policies. This manuscript describes the study's probability-based sample recruitment. Furthermore, we identify this initiative as a resource for evaluating the impact of flavored tobacco restriction policies and informing policy implementation efforts.</p><p><strong>Implications: </strong>This manuscript provides an overview of the methodology and baseline characteristics for a new longitudinal cohort of youth and young adults, the Tobacco Epidemic Evaluation Network (TEEN+) study. The TEEN+ study data can be used to evaluate the impact of flavored tobacco product restriction policies and informing policy implementation efforts.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"644-651"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}