Erin L Sutfin, Seth M Noar, Allison J Lazard, Stephanie Belina, Alexandra R Zizzi, Rime Jebai, Cynthia K Suerken, Beth A Reboussin, Kimberly G Wagoner, Jennifer Cornacchione Ross
{"title":"Development and Testing of Waterpipe Tobacco Text and Pictorial Warnings among Young Adults in the U.S.","authors":"Erin L Sutfin, Seth M Noar, Allison J Lazard, Stephanie Belina, Alexandra R Zizzi, Rime Jebai, Cynthia K Suerken, Beth A Reboussin, Kimberly G Wagoner, Jennifer Cornacchione Ross","doi":"10.1093/ntr/ntaf170","DOIUrl":"https://doi.org/10.1093/ntr/ntaf170","url":null,"abstract":"<p><strong>Introduction: </strong>Waterpipe tobacco smoking (WTS) is associated with health harms, yet the U.S. requires only a single text warning.</p><p><strong>Methods: </strong>We developed thirty text warnings, across 12 health themes, based on scientific evidence and expert input. Text warnings were tested in an online survey among a national convenience sample of U.S. young adults (18-29, Study 1). We then selected six text warnings and paired each with three images, creating 18 pictorial warnings that were tested in an online survey among a second national convenience sample of U.S. young adults (18-29, Study 2).</p><p><strong>Results: </strong>Study 1 had 822 participants (33% past-year WTS, 43.6% susceptible, 23.5% not susceptible). Text warnings performed similarly, and there were no differences across themes on perceived message effectiveness (PME) (Means=3.59-3.79), learning (Means=2.71-2.91), or cognitive elaboration (Means=3.48-3.68). There were differences between user groups for PME (F1,2=32.26, p<0.05), cognitive elaboration (F1,2=32.26, p<0.05), and learning (F1,2=9.53, p<0.05); yet differences did not vary by theme. Study 2 had 902 participants (33.5% past-year WTS, 33.4% susceptible, 33.2% not susceptible). We found significant differences in PME, emotional reactions, and visual-verbal congruency between the three pictorial warnings tested for each text warnings; however, ratings were similar across user groups. We selected the most promising pictorial warning for each corresponding text warning.</p><p><strong>Conclusions: </strong>Text warnings covering a range of health harms may be effective and should be considered by the FDA. Moreover, the U.S. and other countries should consider utilizing pictorial warnings to further enhance comprehension and potential effectiveness in discouraging WTS.</p><p><strong>Implications: </strong>We developed and tested text and pictorial warnings that could be used to communicate the harms of waterpipe tobacco smoking (WTS) to young adults in the U.S., who have the highest rates of WTS. A wide range of text warning statements was found to elicit moderately high ratings of perceived message effectiveness and cognitive elaboration. A more comprehensive set of text warnings could provide further understanding of the harms of WTS. Moreover, pictorial warnings could further enhance comprehension of health harms and their potential effectiveness in discouraging WTS.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charlotte Xin Li, Pin-Chun Wang, Ariadna Feliu, Anthony A Laverty, Cristina Martinez, Filippos T Filippidis
{"title":"Perceptions of e-cigarettes and heated tobacco products among never users of nicotine in the European Union.","authors":"Charlotte Xin Li, Pin-Chun Wang, Ariadna Feliu, Anthony A Laverty, Cristina Martinez, Filippos T Filippidis","doi":"10.1093/ntr/ntaf168","DOIUrl":"https://doi.org/10.1093/ntr/ntaf168","url":null,"abstract":"<p><strong>Introduction: </strong>Emerging tobacco and nicotine products, such as e-cigarettes and heated tobacco products (HTPs), are gaining popularity, particularly among young people. This study examines the perceptions of e-cigarettes and HTPs among nicotine-naive individuals and their variations across sociodemographic subgroups.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of the Special Eurobarometer 99.3 (May-June 2023) among never users of tobacco or nicotine products in the European Union (EU) (n = 13 436). We estimated the weighted prevalence of perceptions of e-cigarettes and HTPs: appeal, perceived effectiveness for smoking cessation, support for them being regulated like cigarettes, and support for keeping them out of sight in points-of-sale. Multi-level Poisson regression models examined associations of sociodemographic factors with these perceptions.</p><p><strong>Results: </strong>Among never users in the EU, 2.6% found e-cigarettes appealing, while 2.0% found HTPs appealing. 50.8% and 58.8% of participants supported strict regulations and point-of-sale restrictions for these products, respectively. Younger age groups were more likely to find e-cigarettes (Prevalence Ratio [PR] = 1.70, for ages 15-39 vs. 55+) and HTPs (PR = 1.88, PR = 1.54 for ages 15-24 and 25-39) appealing and view them as effective for smoking cessation. Support for regulations similar to cigarettes was higher among women, individuals with higher education, those living with children, and those without financial difficulties.</p><p><strong>Conclusion: </strong>While the appeal of these products to never users remained low overall, the study found that young people were more likely to find them appealing, posing a risk for experimentation. Meanwhile, over 50% of respondents supported stricter regulations, which could influence policy changes in this area.</p><p><strong>Implications: </strong>Although appeal of e-cigarettes and Heated Tobacco Products (HTPs) was relatively low among people who have never used e-cigarettes, HTPs or smoking tobacco in the European Union, appeal was higher among younger age groups, which are often targeted by the industry. We also found substantial support for stricter regulatory policies for e-cigarettes and HTPs across the EU. These findings might encourage governments to increase restrictions around these emerging nicotine and tobacco products.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meng Yang, David K Lohrmann, Chunfeng Huang, Wura Jacobs, Hsien-Chang Lin
{"title":"Optimal Urinary Cotinine and Total Nicotine Equivalents (TNE-2) Cut-points for Distinguishing Tobacco Users from Non-Users among American Youth.","authors":"Meng Yang, David K Lohrmann, Chunfeng Huang, Wura Jacobs, Hsien-Chang Lin","doi":"10.1093/ntr/ntaf169","DOIUrl":"https://doi.org/10.1093/ntr/ntaf169","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco use remains a major public health concern, especially during adolescence when most tobacco habits begin. Tobacco use among youth is commonly assessed through self-reports, but the validity is questioned. Biomarkers, including cotinine and total nicotine equivalents (TNE-2), offer objective indicators of tobacco exposure. However, optimal cut-points for cotinine and TNE-2 to differentiate users and non-users among youth are lacking.</p><p><strong>Methods: </strong>This study utilized data from Wave 5 (2018-2019) of the Population Assessment of Tobacco and Health (PATH) Study, including 1,396 youth aged 13-17 years. Receiver Operating Characteristic (ROC) analysis was used to determine optimal cut-points for cotinine and TNE-2. ROC curves were employed to determine optimal cut-points for differentiating past-7-day and past-30-day tobacco users from non-users, then stratified by sex. Sensitivity and specificity of the cut-points were assessed.</p><p><strong>Results: </strong>The optimal cotinine cut-point for distinguishing past-7-day any tobacco use was 7.18 ng/mL. Individuals with levels ≥7.18 ng/mL were classified as tobacco users, while those below this threshold were not. Males had a higher cut-point (11.85 ng/mL) compared to females (7.18 ng/mL). Similar patterns were observed for past-30-day any tobacco use. Sensitivity of the cut-point ranged from 69% to 86%; specificity ranged from 75% to 92%.</p><p><strong>Conclusions: </strong>This study identified optimal cotinine and TNE-2 cut-points for differentiating past-7-day and past-30-day tobacco use from non-use among youth, providing a valuable tool for objective assessment and validation of tobacco use status. Variations in cut-points by sex highlight the importance of sex differences when evaluating tobacco use status for the youth population.</p><p><strong>Implication: </strong>This study addresses challenges associated with assessing and validating self-report tobacco use among youth by identifying a potentially better way of dealing with the limitations of self-report measures for accurately capturing tobacco use behaviors, particularly among adolescents. Use of biomarkers such as cotinine and TNE-2 provides a valuable alternative approach for determining tobacco use status among youth. Incorporation of biomarker data into tobacco control efforts can improve the accuracy of tobacco use assessment, enhance understanding of youth tobacco behaviors, and ultimately contribute to reduction of tobacco use and associated health risks among this vulnerable population.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josephine T Hinds, Perel Y Wein, Esther Stern, Loriann Cioffi, Kaitlin Cuddleston, Talya Gordon, Caroline Delbourgo Patton, Andrea H Weinberger
{"title":"Reporting of tobacco use and health outcomes among transgender and gender expansive people in gender-affirming hormone therapy research: 1980-2024.","authors":"Josephine T Hinds, Perel Y Wein, Esther Stern, Loriann Cioffi, Kaitlin Cuddleston, Talya Gordon, Caroline Delbourgo Patton, Andrea H Weinberger","doi":"10.1093/ntr/ntaf158","DOIUrl":"https://doi.org/10.1093/ntr/ntaf158","url":null,"abstract":"<p><strong>Purpose: </strong>Transgender/gender expansive (TGE) people, who use tobacco at high rates, are frequently advised not to use tobacco during gender-affirming hormone therapy (GAHT) due to increased risk of negative health events. However, there is no summary of studies reporting risk of negative health events for TGE people with versus without tobacco use during GAHT. This systematic review assesses what is known about tobacco use and health outcomes in studies of TGE people pursuing GAHT.</p><p><strong>Methods: </strong>Searches were conducted in PubMed, Embase, PsycInfo, Google Scholar, and Mednar. The protocol was registered in Prospero (CRD42023416390).</p><p><strong>Results: </strong>107 studies published from 1980-2024 mentioned tobacco and GAHT for TGE patients. Most studies focused on adults (80.4%). Patient samples were feminine/transfeminine (29.9%), masculine/transmasculine (26.2%) or \"both\"/combinations (43.0%). Most studies (96.3%) reported smoking prevalence, ranging from 4.2% to 73.0%. Forty-three studies (40.2%) explored patient outcomes as they related to GAHT and tobacco use, but significantly increased risk of adverse health events for TGE people receiving GAHT with tobacco use relative to no tobacco use were found in only five studies (4.7%). Tobacco cessation was not mentioned in 79.4% of studies, and no studies reported offering cessation assistance.</p><p><strong>Conclusion: </strong>Identifying whether TGE people pursuing GAHT experience unique or exacerbated outcomes based on whether and what type of tobacco they use is critical for TGE-focused clinicians and researchers. This systematic review found few studies that identified empirical associations between tobacco use and GAHT-related health outcomes. Accurate tobacco assessment is essential to discern associations with GAHT-related outcomes.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiya Ji, Lu Chen, Susu Zhuang, Liwen Wei, Lili Gou, Cheng Shi, Hanrui Jia, Xupeng Chen
{"title":"Bidirectional Association Between E-Cigarette Use and Depression: A Meta-Analysis.","authors":"Shiya Ji, Lu Chen, Susu Zhuang, Liwen Wei, Lili Gou, Cheng Shi, Hanrui Jia, Xupeng Chen","doi":"10.1093/ntr/ntaf163","DOIUrl":"https://doi.org/10.1093/ntr/ntaf163","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have indicated the potential bidirectional association between the use of e-cigarettes (ECs) and depression. However, this hypothesis is yet to be thoroughly investigated. In this meta-analysis, the two-way relationship is examined.</p><p><strong>Methods: </strong>As of November 2024, major electronic databases were searched. Two sets of pooled risk estimates were computed by employing random effects models: one for EC use predicting depression and the other for depression predicting EC use. The forms of depressive presentation involved in this study include major depressive disorder, dysthymia, and general depressive symptoms. The results were presented in terms of adjusted odds ratios (ORs) along with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>We identified a total of 1601 references and included 27 studies involving 1 671 773 participants. Both current EC use (OR 1.96, 95% CI: 1.73-2.23) and ever EC use (OR 1.88, 95% CI: 1.59-2.21) could notably forecast depression. Pooled results also indicated that depression might significantly predict current EC use (OR 1.36, 95% CI: 1.15-1.61) and ever EC use (OR 1.53, 95% CI: 1.25-1.88).</p><p><strong>Conclusion: </strong>EC use might be a significant predictor for depression and depression might be a significant predictor for EC use, highlighting the need to strengthen mental health warnings on e-cigarettes and integrate EC use screening in depression assessments.</p><p><strong>Implications: </strong>Considering the bidirectional link between EC use and depression, clinical screening, public health interventions and stricter marketing regulation are crucial to mitigate risks. Future research should focus on the mechanisms and causal pathways of e-cigarettes and depression.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin P Conway, Eden Beyene, Lihong Cui, Kathleen R Merikangas
{"title":"Comorbidity and Familial Aggregation of Mood Disorders and Cigarette Smoking in a Controlled Family Study.","authors":"Kevin P Conway, Eden Beyene, Lihong Cui, Kathleen R Merikangas","doi":"10.1093/ntr/ntaf164","DOIUrl":"https://doi.org/10.1093/ntr/ntaf164","url":null,"abstract":"<p><strong>Introduction: </strong>Cigarette smoking and nicotine dependence are highly comorbid with mood disorders. Although the family-study method can be used to examine mechanisms of comorbidity, family studies of mood disorders and smoking are limited. This study examined the familial aggregation of mood disorder subtypes and multiple cigarette-smoking behaviors.</p><p><strong>Methods: </strong>Lifetime smoking and mood disorders were assessed by semi-structured diagnostic interviews and family-history reports in adult probands (n = 297) and relatives (n = 510) from a community-based family study in the Washington (DC) metropolitan area. Familial aggregation and coaggregation of mood-disorder subtypes (major depression, bipolar-I, bipolar-II) with smoking behaviors (ever, daily, heavy, nicotine dependence) were estimated via mixed-effects models, adjusting for age, sex, and comorbid mood and anxiety disorders.</p><p><strong>Results: </strong>All smoking behaviors were familial. Smoking behaviors did not co-aggregate with mood disorders. In relatives, comorbid major depression was associated with all smoking behaviors; bipolar-I and bipolar-II were associated with heavy smoking and nicotine dependence. Anxiety was associated with ever and heavy smoking. Anxiety disorders typically preceded onset of smoking.</p><p><strong>Conclusions: </strong>Family history of smoking and personal history of mood and anxiety disorders constitute independent risk factors for smoking. Major depression and bipolar subtypes are potent risk factors for severe smoking behaviors.</p><p><strong>Implications: </strong>Results from this community-based family study suggest that preventing or treating cigarette smoking may reduce the risk of smoking within families. Additionally, intervening on anxiety and mood disorders may prevent cigarette smoking and the progression to severe smoking behaviors. Interventions that incorporate familial and individual factors may be especially effective at reducing smoking and improving public health.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gregory T Jones, Michael J A Williams, Manar Khashram, Sandra Fitzgerald, Oliver T A Lyons, Claire L Griffin, Sarah Lesche, Jolanta Krysa, Sean Coffey
{"title":"A DNA Methylation Marker, cg05575921 (AHRR), Outperforms Self-Reported Smoking Exposure for Its Association With Cardiovascular Disease Prevalence.","authors":"Gregory T Jones, Michael J A Williams, Manar Khashram, Sandra Fitzgerald, Oliver T A Lyons, Claire L Griffin, Sarah Lesche, Jolanta Krysa, Sean Coffey","doi":"10.1093/ntr/ntaf165","DOIUrl":"https://doi.org/10.1093/ntr/ntaf165","url":null,"abstract":"<p><strong>Background: </strong>The differential DNA methylation (DNAm) of the CpG site cg05575921, within the gene body of AHRR, has been shown to be a robust indicator of tobacco smoking exposure. This study aimed to determine if cg05575921 at AHRR DNAm had a clinically relevant association with prevalent cardiovascular disease (CVD) and compare its predictive performance with self-reported smoking assessments.</p><p><strong>Methods: </strong>Whole blood cg05575921 (AHRR) DNAm was assessed using a simple droplet digital PCR assay in a cohort of 2784 elderly individuals. DNAm values were used to impute smoking status and its independent association with prevalent CVD.</p><p><strong>Results: </strong>Consistent with previous reports, cg05575921 (AHRR) had significant, sensitive, and specific associations with self-reported smoking status (SRSS: never, ex-, current. <0.0001 between groups). This DNAm marker was also associated with the length of smoking cessation in ex-smokers (rho 0.55, p < .0001, Spearman rank correlation). A key finding of this study was that cg05575921 DNAm had a distinct non-linear relationship with a history of prevalent CVD. DNAm-imputed smoking status (ex-smoker quit >21 years, ex-smoker quit <21 years, and current smoker), remained significantly associated with CVD after covariant adjustment, which included SRSS (OR 2.5, 3.1, and 6.0, p < .0001, respectively). Even among never smokers, cg05575921 values were also significantly associated with CVD (Mann-Whitney U test p < .0001).</p><p><strong>Conclusions: </strong>Imputed (cg05575921 AHRR) DNAm smoking status appears to have a significant and independent association with the prevalence of CVD. This association is stronger than that of conventional SRSS and may suggest potential utility to improve existing CVD risk prediction scores.</p><p><strong>Implications: </strong>The results of this study were consistent with previous reports showing that the DNA methylation status of cg05575921 is highly accurate in identifying smoking status (current, ex-smokers, or never smokers), including the length of time an ex-smoker had quit. The marker's levels also had a strong relationship with prevalent CVD, including after adjusting for other risk factors, such as age, diabetes, and even self-reported smoking status. This study makes a strong contribution to a growing body of work suggesting that this DNAm marker may have substantial clinical utility to aid \"precision-medicine\" chronic disease risk prediction.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jenny E Ozga, Alexander W Steinberg, James D Sargent, Zhiqun Tang, Cassandra A Stanton, Laura M Paulin
{"title":"An Examination of Sex Differences and Cigarette Smoking as Predictors of COPD Prevalence and Incidence in Older US Adults.","authors":"Jenny E Ozga, Alexander W Steinberg, James D Sargent, Zhiqun Tang, Cassandra A Stanton, Laura M Paulin","doi":"10.1093/ntr/ntaf162","DOIUrl":"10.1093/ntr/ntaf162","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined the main and interactive effects of sex, cigarette smoking status, cigarette pack-years, and second-hand smoke exposure on COPD prevalence and incidence.</p><p><strong>Methods: </strong>COPD prevalence was estimated for US adults aged 40+ years from Wave 1 of the Population Assessment of Tobacco and Health Study (n = 12 296). Incidence analyses included adults from the initial sample without a COPD diagnosis (n = 6611). Multivariable Poisson regressions assessed prevalence and incidence based on self-reported sex and cigarette smoking, adjusted for covariates.</p><p><strong>Results: </strong>COPD prevalence was 7.4% and 9.4% and incident COPD was 5.0% and 8.7% for males and females, respectively. The adjusted prevalence ratio (aPR) for COPD for females was 1.26 [95% CI = 1.11, 1.44], and the adjusted risk ratio (aRR) for incident COPD was 1.73 [1.41, 2.12]. Stratified by smoking status, female (vs. male) sex was associated with aPRs of 1.26 [1.10, 1.44] and 1.35 [0.98, 1.84] and aRRs of 1.32 [1.00, 1.75] and 2.58 [1.79, 3.72] for adults who ever or never smoked, respectively. Smoking status (p = .003) and pack-years (p = .006) increased risk of COPD incidence for both males and females, but to a greater extent for males.</p><p><strong>Conclusions: </strong>Female sex was associated with significantly higher COPD incidence, which was not explained by cigarette smoking, second-hand smoke exposure, e-cigarette use, or other covariates. Cigarette-related COPD risk factors increased risk of COPD incidence for both males and females but to a greater extent for males. Future research can include examining alternative risk factors or diagnostic biases contributing to higher incident COPD among females.</p><p><strong>Implications: </strong>Prior studies show that COPD prevalence has been increasing for women in the United States, but the basis for this change remains unclear. This study shows how female (vs. male) sex is associated with significantly increased risk for COPD prevalence and incidence among a nationally representative sample of older (aged ≥40 years) US adults using data from 2013 to 2019, which was not accounted for by cigarette smoking, second-hand smoke exposure, e-cigarette use, or other covariates. Work is needed on alternative COPD risk factors or diagnostic biases contributing to higher incident COPD among females.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meman Diaby, Osayande Agbonlahor, Maggie K Richardson, Joy L Hart, Shyanika W Rose, Delvon T Mattingly
{"title":"Discrimination Distress and Current Combustible and Non-combustible Tobacco Product Use Among US Youth, 2023.","authors":"Meman Diaby, Osayande Agbonlahor, Maggie K Richardson, Joy L Hart, Shyanika W Rose, Delvon T Mattingly","doi":"10.1093/ntr/ntaf166","DOIUrl":"https://doi.org/10.1093/ntr/ntaf166","url":null,"abstract":"<p><strong>Introduction: </strong>Discrimination is the unfair treatment of people based on their identity. Youth who experience discrimination may cope with associated distress by using tobacco products, with amplified health consequences depending on the type of product.</p><p><strong>Methods: </strong>We used data from the 2023 National Youth Tobacco Survey (n = 22 069) and derived an overall continuous measure from the 15-item Adolescent Discrimination Distress Index, as well as three continuous discrimination distress sub-indices: educational, institutional, and peer (range for each: 0-5). We defined current tobacco use as two outcomes: any past 30-day use of combustible (cigarettes, cigars, hookah, roll-your-own, pipe, bidis) and non-combustible (e-cigarettes, smokeless tobacco, snus, heated tobacco, nicotine pouches, oral nicotine) products. To estimate associations between discrimination measures and tobacco use outcomes, we conducted multivariable logistic regression.</p><p><strong>Results: </strong>Youth experienced more educational (mean = 0.56) than peer (mean = 0.48) and institutional (mean = 0.38) discrimination distress, and the prevalence of current combustible and non-combustible tobacco use was 3.89% and 9.67%. A single unit increase in overall discrimination distress was associated with increased odds of combustible (AOR: 1.26, 95% CI: 1.08 to 1.47) and non-combustible (AOR: 1.23, 95% CI: 1.09 to 1.39) tobacco use. For subindices, only a single unit increase in institutional discrimination distress was associated with current combustible tobacco use (AOR: 1.30, 95% CI: 1.06 to 1.59).</p><p><strong>Conclusion: </strong>Overall discrimination distress was associated with current use of combustible and non-combustible tobacco products; however, only institutional discrimination distress was associated with combustible product use. These findings highlight the importance of considering discriminatory contexts as they relate to potential youth tobacco use as a distress-coping mechanism.</p><p><strong>Implications: </strong>This study adds to the growing evidence that discrimination distress, particularly in institutional contexts, is associated with youth combustible tobacco use. By highlighting the unique role of institutional discrimination in tobacco use, our findings emphasize the need for targeted interventions to address discriminatory environments in these settings. These results underscore the importance of integrating anti-discrimination policies and support systems into tobacco prevention efforts to reduce maladaptive behaviors among youth. This research also suggests examining how differing discrimination contexts may shape nicotine use behavior, potentially revealing insights helpful in tailoring prevention strategies.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Alnahari, Vera Inoue Terris, Lina Salam, Gamila Abdelhalim, Juliet P Lee
{"title":"From Invisibility to Action: Tobacco Control Research for Arab Americans in the New Middle Eastern/North African (MENA) Ethnic Category.","authors":"Sarah Alnahari, Vera Inoue Terris, Lina Salam, Gamila Abdelhalim, Juliet P Lee","doi":"10.1093/ntr/ntaf161","DOIUrl":"https://doi.org/10.1093/ntr/ntaf161","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}