Neuroscience最新文献_第8页

Exploring the interaction of reading and attention through connectivity with the frontal-eye-field 通过前眼视野的连通性探索阅读与注意的相互作用。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-04 DOI: 10.1016/j.neuroscience.2025.09.007

Shaylyn Kress , Josh Neudorf , Chelsea Ekstrand , Ron Borowsky

{"title":"Exploring the interaction of reading and attention through connectivity with the frontal-eye-field","authors":"Shaylyn Kress , Josh Neudorf , Chelsea Ekstrand , Ron Borowsky","doi":"10.1016/j.neuroscience.2025.09.007","DOIUrl":"10.1016/j.neuroscience.2025.09.007","url":null,"abstract":"<div><div>Attentional processes are crucial to ensure successful reading, and theories of dyslexia propose that dysfunctional attention networks may contribute to the observed reading deficits. The goals of this study were to localize a region of the frontal-eye-field (FEF) involved in both reading and attention and examine its connectivity with regions in the reading and attention networks, given the known role of the FEF in attentional processes and theorized role in reading. In Experiment 1, we revisited the results of our previous hybrid reading and attention study. We observed a significant reading × attention interaction in BOLD intensity in the FEF, specifically the ventrolateral portion of Brodmann’s Area 6 (A6vl). In Experiment 2, we used Human Connectome Project diffusion tensor imaging data to examine the connectivity profile of the FEF-A6vl. We observed high communicability between the A6vl and basal ganglia (which plays a role in rhythm during syllabic processing). These connections support tract clusters which terminated in the cerebellar Crus I/II (which play roles in eye movements and semantics) and cerebral superior parietal lobule (which plays a role in attentional orienting and phonetic decoding). The results of this study elucidate the reading × attention interaction in the FEF-A6vl, and may have implications for developing treatments to improve reading in individuals with dyslexia.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 249-261"},"PeriodicalIF":2.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blackcurrant anthocyanins improve visual contrast resolution for optokinetic responses in aging mice 黑加仑花青素改善衰老小鼠光动力学反应的视觉对比度分辨率。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-04 DOI: 10.1016/j.neuroscience.2025.09.003

Yuko Sugita , Koki Kobayashi , Hung-Ya Tu , Daisuke Okuzaki , Takahisa Furukawa

{"title":"Blackcurrant anthocyanins improve visual contrast resolution for optokinetic responses in aging mice","authors":"Yuko Sugita , Koki Kobayashi , Hung-Ya Tu , Daisuke Okuzaki , Takahisa Furukawa","doi":"10.1016/j.neuroscience.2025.09.003","DOIUrl":"10.1016/j.neuroscience.2025.09.003","url":null,"abstract":"<div><div>Visual motion perception declines during natural aging in most animals including humans. Edible berries of blackcurrant (BC) and its extracted anthocyanins (BCAs) have beneficial effects on human eyes. However, the effect of BCAs on the perception of moving objects and other dynamic visual patterns remains unknown. In the current study, we investigated whether BCAs improve visual movement perception in aging mice. The aging mice were fed either a standard diet or a standard diet containing BC. In addition, BCAs, the major component of BC, was orally administered to aging mice. The optokinetic responses (OKR) to the vertical sinusoidal patterns were then compared between the groups. To assess the transcriptional effects of delphinidin 3-O-β-rutinoside (D3R), a major BCA, we performed RNA-seq analysis using total RNA purified from the retina and V1 of control and D3R-administered aging mice. Larger OKRs were observed in BC-fed mice than in control mice at low grating contrast, suggesting that the contrast resolution to track moving patterns was improved. Similar results were observed in mice orally administered BCAs. Furthermore, we examined the effects of BCAs on the aging mouse retina and the primary visual cortex (V1) at the gene expression level. RNA-seq analysis of BCA-administered aging mouse retinas and V1s indicated activation of genes related to neural protection and neuronal survival, including BDNF and EGF. Taken together, the current study suggests that BCA ingestion alleviates the decline in contrast-dependent moving visual function in aging mice, accompanied by transcriptional profile change of the V1 and retina.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 67-80"},"PeriodicalIF":2.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glymphatic-meningeal lymphatic system, a new therapeutic target for sleep disorders 淋巴-脑膜淋巴系统：睡眠障碍的新治疗靶点。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-04 DOI: 10.1016/j.neuroscience.2025.09.008

Ming Xiao , Charles Marshall , Kuiying Yin

{"title":"Glymphatic-meningeal lymphatic system, a new therapeutic target for sleep disorders","authors":"Ming Xiao , Charles Marshall , Kuiying Yin","doi":"10.1016/j.neuroscience.2025.09.008","DOIUrl":"10.1016/j.neuroscience.2025.09.008","url":null,"abstract":"<div><div>Sleep disorders encompass a range of diseases and symptoms that disrupt individual sleep patterns, degrade sleep quality, and diminish sleep efficiency. Currently, the mechanisms governing sleep regulation and the etiology of sleep disorders remain unclear, leading to clinical treatments that are primarily symptomatic due to the absence of precise intervention methods. Recent studies suggest that glymphatic-meningeal lymphatic route is responsible for the clearance of macromolecular metabolites from the brain, thus playing a pivotal role in maintaining sleep homeostasis and circadian rhythm. Brain lymphatic draining may be a new target for early diagnosis, drug development, and precise treatment of sleep disorders. The following scientific issues merit exploration through a profound, cross-disciplinary collaboration between basic and clinical research: the intrinsic link between the polymorphism of aquaporin-4, a glymphatic functional marker, and the occurrence of sleep disorders; the clinical value of glymphatic-meningeal lymphatic draining imaging in early screening for sleep disturbance-related brain impairments; and the feasibility of enhancing glymphatic-meningeal lymphatic drainage in the intervention of sleep disorders.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 206-212"},"PeriodicalIF":2.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive prediction using regional connectivities and network biomarkers in Alzheimer’s disease 阿尔茨海默病中使用区域连接和网络生物标志物的认知预测。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-03 DOI: 10.1016/j.neuroscience.2025.08.059

Jinhua Sheng , Jialei Wang , Qiao Zhang , Ruilin Huang , Yan Lu , Tao Li

{"title":"Cognitive prediction using regional connectivities and network biomarkers in Alzheimer’s disease","authors":"Jinhua Sheng , Jialei Wang , Qiao Zhang , Ruilin Huang , Yan Lu , Tao Li","doi":"10.1016/j.neuroscience.2025.08.059","DOIUrl":"10.1016/j.neuroscience.2025.08.059","url":null,"abstract":"<div><div>Achieving a deep understanding of brain mechanisms requires multi-scale perspectives to capture the architecture of complex networks. In this study, we focused on patients with cognitive impairment and constructed individual brain networks from neuroimaging data. We introduced a Significant Edges Selection (SES) method, which effectively extracts the most informative connections while suppressing noise. Using these refined features, we computed network characteristics and applied machine learning models to predict cognitive performance, achieving a prediction accuracy of correlation r = 0.683 under rigorous leave-one-out cross-validation. Importantly, we identified core brain regions and large-scale networks that drive predictive performance. Specifically, the secondary visual (VIS2), frontoparietal control (FPN), and default mode (DMN) networks emerged as the most strongly associated with cognitive decline. Our findings highlight a multi-scale framework, spanning connections, brain regions, and networks, that not only yields robust cognitive prediction but also provides novel insights into AD-related mechanisms. This work advances predictive modeling in Alzheimer’s Disease (AD) and offers valuable guidance for early diagnosis and mechanistic research.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 313-322"},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-channel integrated auditory function test system 一种多通道综合听觉功能测试系统。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-03 DOI: 10.1016/j.neuroscience.2025.08.053

Shijie Xiao , Yihang Zheng , Guanting Lin , Jinxuan Liu , Wei Xiong , Lei Song , Fangyi Chen

{"title":"A multi-channel integrated auditory function test system","authors":"Shijie Xiao , Yihang Zheng , Guanting Lin , Jinxuan Liu , Wei Xiong , Lei Song , Fangyi Chen","doi":"10.1016/j.neuroscience.2025.08.053","DOIUrl":"10.1016/j.neuroscience.2025.08.053","url":null,"abstract":"<div><div>The auditory brainstem response (ABR) remains the gold standard for evaluating hearing function in both animal models and humans. Features of ABR, including threshold, wave I amplitude and latency are critical for diagnosing and investigating the mechanisms of hearing loss. Critically, the rapid proliferation of genetically engineered mouse models in hearing research has created an imperative demand for high-throughput ABR testing capabilities. Currently, the Tucker-Davis Technologies (TDT) system serves as the standard, and nearly exclusive, platform for animal ABR assessment. However, the design of single-animal testing system, with low sampling rates, serves as limitation to certain applications such as large-scale screening and studies of high frequency distortion product otoacoustic emission (DPOAE) and cochlear microphonic (CM). We developed a four-channel ABR system enabling simultaneous testing of four subjects, coupled with a custom acoustic chamber providing > 50 dB noise attenuation across mouse hearing frequencies. The system’s enhanced acoustic and electrical performance obtains high-frequency (>32 kHz) DPOAE and CM recordings beyond the capabilities of the TDT System3 and RZ6. In mouse ABR assessments, it consistently replicates TDT-measured thresholds, wave I latency, and amplitude while tripling test throughput. This comprehensive platform meets modern high-volume ABR demands, delivering superior efficiency and expanded functional assessment for scalable, high-fidelity auditory phenotyping in next-generation research.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 381-393"},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AlzFormer: Video-based space-time attention model for early diagnosis of Alzheimer’s disease AlzFormer：基于视频的阿尔茨海默病早期诊断时空注意模型

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-03 DOI: 10.1016/j.neuroscience.2025.08.062

Taymaz Akan , Sara Akan , Sait Alp , Christina Raye Ledbetter , Mohammad Alfrad Nobel Bhuiyan , for the Alzheimer’s Disease Neuroimaging Initiative

{"title":"AlzFormer: Video-based space-time attention model for early diagnosis of Alzheimer’s disease","authors":"Taymaz Akan , Sara Akan , Sait Alp , Christina Raye Ledbetter , Mohammad Alfrad Nobel Bhuiyan , for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neuroscience.2025.08.062","DOIUrl":"10.1016/j.neuroscience.2025.08.062","url":null,"abstract":"<div><div>Early and accurate Alzheimer’s disease (AD) diagnosis is critical for effective intervention, but it is still challenging due to neurodegeneration’s slow and complex progression. Recent studies in brain imaging analysis have highlighted the crucial roles of deep learning techniques in computer-assisted interventions for diagnosing brain diseases. In this study, we propose AlzFormer, a novel deep learning framework based on a space–time attention mechanism, for multiclass classification of AD, MCI, and CN individuals using structural MRI scans. Unlike conventional deep learning models, we used spatiotemporal self-attention to model inter-slice continuity by treating T1-weighted MRI volumes as sequential inputs, where slices correspond to video frames. Our model was fine-tuned and evaluated using 1.5 T MRI scans from the ADNI dataset. To ensure the anatomical consistency of all the MRI data, All MRI volumes were pre-processed with skull stripping and spatial normalization to MNI space. AlzFormer achieved an overall accuracy of 94 % on the test set, with balanced class-wise F1-scores (AD: 0.94, MCI: 0.99, CN: 0.98) and a macro-average AUC of 0.98. We also utilized attention map analysis to identify clinically significant patterns, particularly emphasizing subcortical structures and medial temporal regions implicated in AD. These findings demonstrate the potential of transformer-based architectures for robust and interpretable classification of brain disorders using structural MRI.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 133-143"},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of glucocorticoid receptors facilitates ex vivo high-frequency network oscillations in the anterior cingulate cortex 糖皮质激素受体的激活促进了前扣带皮层的离体高频网络振荡

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-03 DOI: 10.1016/j.neuroscience.2025.09.002

Daniel Frías Donaire , Yunus Emre Demiray , Ares Alizade , Evangelia Pollali , Anne Albrecht , Gürsel Çalışkan

{"title":"Activation of glucocorticoid receptors facilitates ex vivo high-frequency network oscillations in the anterior cingulate cortex","authors":"Daniel Frías Donaire , Yunus Emre Demiray , Ares Alizade , Evangelia Pollali , Anne Albrecht , Gürsel Çalışkan","doi":"10.1016/j.neuroscience.2025.09.002","DOIUrl":"10.1016/j.neuroscience.2025.09.002","url":null,"abstract":"<div><div>Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, releasing corticosterone (CORT), which binds to glucocorticoid (GR) and mineralocorticoid (MR) receptors in the brain. While stress influences behaviorally relevant network oscillations in limbic regions such as the hippocampus, amygdala, and prefrontal cortex, the direct effects of CORT on these oscillations remain unclear. We examined the acute impact of CORT on anterior cingulate cortex (ACC) oscillations in adult male mice, a hub region for stress and anxiety regulation. Using an ex vivo slice model with cholinergic and glutamatergic activation, we induced beta (10–25 Hz) and slow-gamma (26–45 Hz) oscillations. Our findings show that CORT enhances high-frequency network activity in the ACC in a dose-dependent manner, following an inverted U-shaped dose–response curve, with 1 μM CORT producing significant increases in beta and gamma power. GR activation alone reproduced this effect: the GR agonist dexamethasone mimicked, and the GR antagonist mifepristone blocked, CORT-induced enhancement. MR activation had little effect, and MR antagonism did not prevent the action of CORT. Importantly, acute stress induced by fear conditioning elevated serum CORT levels and enhanced ACC oscillatory activity, with a positive correlation between CORT concentration and oscillation power. Both GR and MR were robustly expressed in the ACC, with expression unaffected by acute stress. These findings highlight the critical role of GR in mediating the effects of CORT on ACC oscillations, which could have implications for understanding neuropsychiatric disorders including anxiety, depression and schizophrenia, where HPA dysfunction, impaired GR signaling, and altered ACC oscillatory activity are commonly observed.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 144-157"},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and implementation of a writing-stroke motor imagery paradigm for multi-character EEG classification 多字脑电分类笔画运动意象范式的设计与实现。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-02 DOI: 10.1016/j.neuroscience.2025.08.058

Hongguang Pan , Hongzheng Gao , Yibo Zhang , Xinyu Yu , Zhuoyi Li , Xinyu Lei , Wenyu Mi

{"title":"Design and implementation of a writing-stroke motor imagery paradigm for multi-character EEG classification","authors":"Hongguang Pan , Hongzheng Gao , Yibo Zhang , Xinyu Yu , Zhuoyi Li , Xinyu Lei , Wenyu Mi","doi":"10.1016/j.neuroscience.2025.08.058","DOIUrl":"10.1016/j.neuroscience.2025.08.058","url":null,"abstract":"<div><div>Motor imagery (MI) based brain–computer interfaces (BCI) decode neural activity to generate command outputs. However, the limited number of distinguishable commands in traditional MI-BCI systems restricts practical applications. To overcome this limitation, we propose a multi-character classification framework based on Electroencephalography (EEG) signals. A structurally simplified MI paradigm for stroke writing is designed, and maximize Euclidean distance trajectory optimization enhances neural separability among five stroke categories. The EEG data cover 11 motor imagery tasks, including five stroke-writing tasks and six related movement tasks such as hand, foot, tongue movements and eye blinks, collected from ten participants. Ensemble Empirical Mode Decomposition (EEMD) eliminates artifact-related Intrinsic Mode Functions (IMFs) and reconstructs the signals. Kernel Principal Component Analysis (KPCA) then conducts nonlinear dimensionality reduction to extract discriminative features. Finally, a recurrent neural network based on Gated Recurrent Units (GRU) performs classification, effectively modeling the temporal dynamics of EEG signals. Experimental results indicate that the optimized stroke paradigm achieves an average classification accuracy of 84.77%, outperforming the unoptimized version at 76.83%. Compared to existing MI-BCI methods, the proposed framework improves classification accuracy and expands the set of distinguishable commands, demonstrating enhanced practicality and effectiveness.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 441-450"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen sulfide in the brain as a silent neuroprotector in Alzheimer’s disease 大脑中的硫化氢作为阿尔茨海默病的无声神经保护器。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-02 DOI: 10.1016/j.neuroscience.2025.08.057

Himanshu Layal , Jitumani Rajbongshi , Rohit Kumar , Shambhavi Pandey , Rajeev Mishra , Pramod K. Yadav

{"title":"Hydrogen sulfide in the brain as a silent neuroprotector in Alzheimer’s disease","authors":"Himanshu Layal , Jitumani Rajbongshi , Rohit Kumar , Shambhavi Pandey , Rajeev Mishra , Pramod K. Yadav","doi":"10.1016/j.neuroscience.2025.08.057","DOIUrl":"10.1016/j.neuroscience.2025.08.057","url":null,"abstract":"<div><div>Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gasotransmitter that has garnered growing attention for its critical roles in cellular signalling and brain function. It regulates NMDA receptors during long-term potentiation, a fundamental mechanism underlying memory consolidation and influences neurotransmission and essential neurophysiological functions. H<sub>2</sub>S is synthesized by three enzymes: cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MST) within the cell. CBS is suggested to be the primary source of H<sub>2</sub>S in the brain parenchyma, while CSE and MST predominantly contribute to its production in cerebral microvessels and astrocytes, respectively. This gasotransmitter plays a pivotal role in modulating hippocampal memory formation, reducing inflammation, promoting vasorelaxation, and supporting angiogenesis. It has been suggested to act as a second messenger or neurotransmitter in the brain, typically activated by neuronal excitation. H<sub>2</sub>S has been widely investigated for its therapeutic potential in Alzheimer’s disease. Notably, Alzheimer’s disease patients display significantly diminished levels of H<sub>2</sub>S compared to age matched subjects. This review offers a consolidated and updated role of H<sub>2</sub>S in Alzheimer’s disease, emphasizing recent mechanistic advances not covered in earlier literature. The work presents a novel perspective by integrating emerging findings on H<sub>2</sub>S based neurotherapeutic strategies.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 181-197"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specific parvalbumin-positive optogenetic stimulations in specific brain regions restore navigational flexibility in an acute MK801 mouse model of schizophrenia 在一个急性MK801精神分裂症小鼠模型中，特定脑区域的特异性小蛋白阳性光遗传刺激恢复了导航灵活性

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-02 DOI: 10.1016/j.neuroscience.2025.09.001

Enrico Patrono , Daniela Černotová , Jan Svoboda , Aleš Stuchlík

{"title":"Specific parvalbumin-positive optogenetic stimulations in specific brain regions restore navigational flexibility in an acute MK801 mouse model of schizophrenia","authors":"Enrico Patrono , Daniela Černotová , Jan Svoboda , Aleš Stuchlík","doi":"10.1016/j.neuroscience.2025.09.001","DOIUrl":"10.1016/j.neuroscience.2025.09.001","url":null,"abstract":"<div><div>Impairments in decision-making and behavioral flexibility in patients with schizophrenia (SCZ) are currently among the most investigated aspects of SCZ. Increased GLUergic excitatory activity and decreased GABAergic inhibitory activity induce mPFC-vHPC γ/θ band desynchronization in many tasks where behavioral flexibility is tested. However, these tasks used “perceptual” decision-making/flexibility but not navigational decision-making/flexibility. Our study investigated the role of frequency-specific optogenetic stimulation of GABAergic parvalbumin-positive (PV+) interneurons in two pivotal brain structures used in flexibility (mPFC) and navigation (vHPC), at frequencies resembling the γ/θ band (50 Hz, γ-like; and 10 Hz, θ-like) in an acute MK801 mouse model of navigational inflexibility. We used a modified version of the active place avoidance task on a rotating arena. The behavioral results revealed that frequency-specific optogenetic stimulation of the mPFC or vHPC had different effects on restoring navigational flexibility. Moreover, immunohistochemical assays confirmed that optogenetic stimulations activated PV+ interneurons that were transfected with the optogenetic actuators, advancing our understanding of the pivotal role of PV+ activity in SCZ-like navigational decision-making/flexibility.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0