Neuroscience最新文献

Rag1−/− mice with T and B lymphocyte deficiency exhibit milder retinal inflammatory response and retinal ganglion cell injury after optic nerve crush T和B淋巴细胞缺乏的Rag1−/−小鼠在视神经挤压后表现出较轻的视网膜炎症反应和视网膜神经节细胞损伤

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-29 DOI: 10.1016/j.neuroscience.2025.04.046

Ying Cheng , Danting Lin , Shen Wu , Xuejing Yan , Qian Liu , Ningli Wang , Jingxue Zhang

{"title":"Rag1−/− mice with T and B lymphocyte deficiency exhibit milder retinal inflammatory response and retinal ganglion cell injury after optic nerve crush","authors":"Ying Cheng , Danting Lin , Shen Wu , Xuejing Yan , Qian Liu , Ningli Wang , Jingxue Zhang","doi":"10.1016/j.neuroscience.2025.04.046","DOIUrl":"10.1016/j.neuroscience.2025.04.046","url":null,"abstract":"<div><div>Bourgeoning literature verified the essential contribution of neuroinflammation in optic nerve injury, here, we aim to investigate the effect of lymphocyte deficiency on retinal ganglion cells (RGCs) survival after optic nerve crush (ONC). 48 wide type (WT) and 48 Rag1<sup>−/−</sup> mice were used to establish the ONC model. AAV2-hSyn1-eGFP was employed to inject into the vitreous body to transfect RGCs 4 weeks before ONC modeling, the confocal scanning laser ophthalmoscopy was utilized to visualize the RGCs in vivo. RBPMS, Iba-1 and GFAP expression were detected by immunofluorescence. The expression of retinal glial biomarkers was detected by qRT-PCR, and the protein expression of occludin and CD3 was detected by WB. Electroretinography and optomotor response were used to evaluate the visual function. Our results showed that a milder RGC loss and GCC thickness decrease were found in Rag1<sup>−/−</sup> mice than in WT mice after ONC in vivo and in vitro (<em>p</em> < 0.05). The morphologic and molecular feature analyses of retinal glial cells showed that the lack of lymphocytes significantly inhibited the number and activation level of microglia after ONC (<em>p</em> < 0.05). Besides, Occludin was significantly decreased and CD3 was upregulated at week 4 after ONC in WT mice compared with Rag1<sup>−/−</sup> mice (<em>p</em> < 0.01). Visual function assessment showed a better visual condition in Rag1<sup>−/−</sup> mice with ONC at week 4 (<em>p</em> < 0.05). Altogether, Rag1<sup>−/−</sup> mice with lymphocyte deficiency exhibit less RGC loss, milder retinal glial activation and better visual function when compared with WT mice after ONC.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 129-137"},"PeriodicalIF":2.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal thyroid hormone deficiency leads to oxidative stress-induced neuronal damage and activation of astrocytes in rat hippocampus: Neuroprotective effect of exercise 围产期甲状腺激素缺乏导致大鼠海马氧化应激诱导的神经元损伤和星形胶质细胞活化：运动的神经保护作用

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-27 DOI: 10.1016/j.neuroscience.2025.04.042

Zohreh Zare , Sam Zarbakhsh , Moslem Mohammadi

{"title":"Perinatal thyroid hormone deficiency leads to oxidative stress-induced neuronal damage and activation of astrocytes in rat hippocampus: Neuroprotective effect of exercise","authors":"Zohreh Zare , Sam Zarbakhsh , Moslem Mohammadi","doi":"10.1016/j.neuroscience.2025.04.042","DOIUrl":"10.1016/j.neuroscience.2025.04.042","url":null,"abstract":"<div><div>Thyroid hormones play a crucial role in proper brain development. This study examined the effects of developmental thyroid hormone deficiency on neuronal survival, glial fibrillary acidic protein (GFAP)-positive cells, and oxidative stress biomarkers in the hippocampus of congenital hypothyroid rats. The effectiveness of treadmill exercise in attenuating oxidative stress-induced neuronal damage and astrocyte activation was also evaluated. Pregnant Wistar rats in the hypothyroid group received propylthiouracil in their drinking water from gestational day 6 until weaning, while control dams received only tap water. Then, male offspring from both groups were further divided into two sub-groups: with or without four weeks of treadmill exercise. After sacrifice, the right hemispheres were processed for cresyl violet staining and immunohistochemistry, while the left hippocampi were used for biochemical assays. Results showed a reduced number of neurons and an increased number of GFAP-positive cells in the CA1 region of hypothyroid rats, with no significant changes in the CA3 region. Additionally, congenital hypothyroidism was associated with increased malondialdehyde levels, decreased glutathione levels, and reduced superoxide dismutase and catalase activity in the hippocampus. Treadmill exercise reduced astrocyte activation and protected neurons by inhibiting oxidative stress. Collectively, our results indicate that congenital thyroid hormone deficiency triggers astrocyte activation and compromises neuronal survival in the CA1 region by inducing oxidative stress. Exercise may serve as a beneficial supplementary treatment for attenuating oxidative stress-induced neuronal damage in congenital hypothyroidism.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 96-104"},"PeriodicalIF":2.9,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of multimodal fusion–based deep learning for Alzheimer’s disease 基于多模态融合的深度学习治疗阿尔茨海默病的研究进展

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-24 DOI: 10.1016/j.neuroscience.2025.04.035

Rong Zhang , Jinhua Sheng , Qiao Zhang , Junmei Wang , Binbing Wang

{"title":"A review of multimodal fusion–based deep learning for Alzheimer’s disease","authors":"Rong Zhang , Jinhua Sheng , Qiao Zhang , Junmei Wang , Binbing Wang","doi":"10.1016/j.neuroscience.2025.04.035","DOIUrl":"10.1016/j.neuroscience.2025.04.035","url":null,"abstract":"<div><div>Alzheimer’s Disease (AD) as one of the most prevalent neurodegenerative disorders worldwide, characterized by significant memory and cognitive decline in its later stages, severely impacting daily lives. Consequently, early diagnosis and accurate assessment are crucial for delaying disease progression. In recent years, multimodal imaging has gained widespread adoption in AD diagnosis and research, particularly the combined use of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). The complementarity of these modalities in structural and metabolic information offers a unique advantage for comprehensive disease understanding and precise diagnosis. With the rapid advancement of deep learning techniques, efficient fusion of MRI and PET multimodal data has emerged as a prominent research focus. This review systematically surveys the latest advancements in deep learning-based multimodal fusion of MRI and PET images for AD research, with a particular focus on studies published in the past five years (2021–2025). It first introduces the main sources of AD-related data, along with data preprocessing and feature extraction methods. Then, it summarizes performance metrics and multimodal fusion techniques. Next, it explores the application of various deep learning models and their variants in multimodal fusion tasks. Finally, it analyzes the key challenges currently faced in the field, including data scarcity and imbalance, inter-institutional data heterogeneity, etc., and discusses potential solutions and future research directions. This review aims to provide systematic guidance for researchers in the field of MRI and PET multimodal fusion, with the ultimate goal of advancing the development of early AD diagnosis and intervention strategies.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 80-95"},"PeriodicalIF":2.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on “The efficacy of early rehabilitation in enhancing vestibular compensation in mice with unilateral vestibular neurectomy by promoting cellular proliferation and glial reaction” “早期康复通过促进细胞增殖和神经胶质反应增强单侧前庭神经切除小鼠前庭代偿的疗效”一文评论

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-24 DOI: 10.1016/j.neuroscience.2025.04.022

Yunxiao Zheng , Linglin Zhou , Yujie Liu , Zixuan Yun , Shuhan Huang , Sulin Zhang , Jun Wang

引用次数: 0

Enhanced EEG-based Alzheimer’s disease detection using synchrosqueezing transform and deep transfer learning 基于同步压缩变换和深度迁移学习的脑电图增强阿尔茨海默病检测

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-24 DOI: 10.1016/j.neuroscience.2025.04.041

Shraddha Jain, Rajeev Srivastava

{"title":"Enhanced EEG-based Alzheimer’s disease detection using synchrosqueezing transform and deep transfer learning","authors":"Shraddha Jain, Rajeev Srivastava","doi":"10.1016/j.neuroscience.2025.04.041","DOIUrl":"10.1016/j.neuroscience.2025.04.041","url":null,"abstract":"<div><div>The most prevalent type of dementia and a progressive neurodegenerative disease, Alzheimer’s disease has a major influence on day-to-day functioning due to memory loss, cognitive decline, and behavioral problems. By using synchrosqueezing representations of EEG signals classified by fine-tuned pre-trained convolutional neural networks, this paper presents an EEG-based classification model for Alzheimer’s detection. EEG signals are converted into image patterns with time-varying oscillatory elements using the synchrosqueezing technique. The classification performances of the pre-trained deep architectures (SqueezeNet, ResNet, InceptionV3, and MobileNet) using these EEG images are compared. The P3 and T5 channels are the most effective for detecting Alzheimer’s disease, according to independent experiments done on EEG signals obtained from 19 scalp electrodes. With classification accuracies of 98.50% and 97.57% for the P3 and T5 channels, respectively, InceptionV3 performs the best. The study also emphasizes that the parietal and temporal lobes’ typical disease dynamics are primarily reflected in the electrical activity of the cerebral cortex.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 105-117"},"PeriodicalIF":2.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct patterns of cognitive enhancement: The role of motor experience in domain-specific and general cognitive functions 认知增强的不同模式：运动经验在特定领域和一般认知功能中的作用

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-22 DOI: 10.1016/j.neuroscience.2025.04.034

Yuying Guan , Yingying Wang , Chenglin Zhou , Jian Wang , Yingzhi Lu

{"title":"Distinct patterns of cognitive enhancement: The role of motor experience in domain-specific and general cognitive functions","authors":"Yuying Guan , Yingying Wang , Chenglin Zhou , Jian Wang , Yingzhi Lu","doi":"10.1016/j.neuroscience.2025.04.034","DOIUrl":"10.1016/j.neuroscience.2025.04.034","url":null,"abstract":"<div><div>This study investigated the impact of motor experience on domain-specific anticipatory skills and domain-general cognitive functions in table tennis players across different expertise levels. Participants were divided into control, expert, and elite groups and assessed using a modified Posner paradigm and a go/no-go task, combined with electroencephalography and multivariate pattern analysis. Accuracy and reaction times were measured under varying task difficulties. The results indicated that elite athletes exhibited superior accuracy, especially in challenging conditions, reflecting their advanced cognitive performance. Electroencephalography analysis revealed a non-linear relationship between motor experience and the mu rhythm, suggesting that elite athletes use more efficient neural processing during anticipation. Conversely, P3 amplitude, related to domain-general cognitive functions, showed a linear improvement, with experts outperforming controls. However, this improvement plateaued at the elite level. Overall, the findings indicate that motor expertise enhances both domain-specific and domain-general cognitive functions through distinct neural adaptation patterns, underscoring the specialized cognitive strategies of elite athletes.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 118-128"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-intensity transcranial ultrasound stimulation and its regulatory effect on pain 低强度经颅超声刺激及其对疼痛的调节作用

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-22 DOI: 10.1016/j.neuroscience.2025.04.033

Yuxi Liu , Xinyuan Tian , Long Chen , Chenxu Xiao , Xinyang Huang , Jing Wang

{"title":"Low-intensity transcranial ultrasound stimulation and its regulatory effect on pain","authors":"Yuxi Liu , Xinyuan Tian , Long Chen , Chenxu Xiao , Xinyang Huang , Jing Wang","doi":"10.1016/j.neuroscience.2025.04.033","DOIUrl":"10.1016/j.neuroscience.2025.04.033","url":null,"abstract":"<div><div>Transcranial ultrasound stimulation is an emerging non-invasive neuromodulation technology with the advantages of deep tissue penetration, high spatial resolution, and minimal side effects. Low intensity transcranial ultrasound stimulation (LITUS) has been shownto bea promising neuromodulation treatment for psychiatric and neurological disorders. Notably, significant progress has been made recently in both the application of LITUS in pain disorders and the elucidation of its analgesic mechanisms. This review provides an overview of LITUS and its state-of-the-art mechanisms, including cavitation, mechanical, and thermal effects. We summarize studies spanning from animal models to human trials, highlighting the analgesic effects of transcranial ultrasound stimulation on pain-related neural pathways. Furthermore, we explore potential analgesic mechanisms, such as the suppression of neural activity in the ascending pain pathway and other associated processes.Lastly, we discuss the potential of LITUS for future integrative treatments of chronic pain and psychomotor disorders, as well as its broader therapeutic applications.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 59-68"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between social networking and dementia: A systematic review of observational studies 社交网络与痴呆之间的关系：观察性研究的系统回顾

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-19 DOI: 10.1016/j.neuroscience.2025.04.019

Faheem Arshad , Deenadayalan Boopalan , Sonali Arora , Howard J. Rosen , Suvarna Alladi

{"title":"Association between social networking and dementia: A systematic review of observational studies","authors":"Faheem Arshad , Deenadayalan Boopalan , Sonali Arora , Howard J. Rosen , Suvarna Alladi","doi":"10.1016/j.neuroscience.2025.04.019","DOIUrl":"10.1016/j.neuroscience.2025.04.019","url":null,"abstract":"<div><div>Poor social networking (SN) is associated with the development of cognitive impairment and dementia. Our objective was to perform a systematic review of the evidence on the associations between SN and the incidence of dementia, disease pathology, level of cognition, and brain structure. Bibliographic databases (PubMed, Embase, Cochrane Library, CINAHL) and additional sources (Open Gray, Google Scholar, manual searches) were screened through November 30, 2024. Observational studies assessing the SN-dementia link were selected, with data extraction and bias evaluation performed independently by two authors via the PRISMA checklist and Newcastle-Ottawa Scale. We included 17 observational studies (355 initially screened), involving 20,678 participants aged 40–90 years, published between 2000 and 2024. Studies have utilized various SN assessment tools and cognitive measures, including the MMSE and MoCA. Poor SN was consistently associated with increased risks of dementia, cognitive decline, and severe disease pathology, particularly Alzheimer’s disease (AD). Larger and more integrated SNs were linked to better cognitive resilience and lower conversion rates from mild cognitive impairment (MCI) to dementia. One study on frontotemporal dementia (FTD) indicated that the SN might mitigate cortical atrophy. SN size and density are also correlated with favorable structural brain changes, such as greater gray matter volume. This review highlights SN as a modifiable factor in dementia risk. However, its role in non-AD dementia, particularly FTD, requires further investigation. Future research should include more culturally diverse and methodologically robust studies. Randomized controlled trials will be important to determine whether intervention to expand social networks decreases incidence of progression of dementia.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 138-148"},"PeriodicalIF":2.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroproteomics applied to the study of visual cortex plasticity 神经蛋白质组学在视觉皮层可塑性研究中的应用

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-19 DOI: 10.1016/j.neuroscience.2025.04.021

Francesco Mattia Rossi , Tommaso Pizzorusso

{"title":"Neuroproteomics applied to the study of visual cortex plasticity","authors":"Francesco Mattia Rossi , Tommaso Pizzorusso","doi":"10.1016/j.neuroscience.2025.04.021","DOIUrl":"10.1016/j.neuroscience.2025.04.021","url":null,"abstract":"<div><div>The huge complexity of neuronal circuits arises from a temporarily overlapped influence of genetic and environmental factors (Nature and Nurture). During specific temporal windows of postnatal development, the so-called critical or sensitive periods of plasticity, the brain is particularly susceptible to the effects of experience, though this sensitivity declines with age. The most widely used experimental paradigm for studying critical periods of plasticity is the ocular dominance model in the mammalian visual cortex. Recent advancements in large-scale methodological approaches have enabled the analysis of the cellular and molecular factors regulating plasticity, highlighting the complex interaction among various metabolic and regulatory pathways. Traditionally, genomic and transcriptomic techniques have been employed to investigate the Central Nervous System in a comprehensive manner, including studies on critical period plasticity in the visual cortex. However, it is the technical advancements in proteomic approaches that have established neuroproteomics as a powerful tool for investigating both normal and pathological brain states. Despite its potential, proteomics has been underutilized in studying visual cortical plasticity. Here, we review existing studies and emphasize the importance of exploiting neuroproteomics, and of integrating with other complementary “omic” approaches, to accurately identify the true active cellular agents and ultimate mediators of brain functions.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 8-16"},"PeriodicalIF":2.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor learning is regulated by postnatal GDNF levels in Purkinje cells 运动学习是由出生后浦肯野细胞中的GDNF水平调节的

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-18 DOI: 10.1016/j.neuroscience.2025.04.030

Elina Nagaeva , Giorgio Turconi , Kärt Mätlik , Mikael Segerstråle , Soophie Olfat , Vilma Iivanainen , Tomi Taira , Jaan-Olle Andressoo

{"title":"Motor learning is regulated by postnatal GDNF levels in Purkinje cells","authors":"Elina Nagaeva , Giorgio Turconi , Kärt Mätlik , Mikael Segerstråle , Soophie Olfat , Vilma Iivanainen , Tomi Taira , Jaan-Olle Andressoo","doi":"10.1016/j.neuroscience.2025.04.030","DOIUrl":"10.1016/j.neuroscience.2025.04.030","url":null,"abstract":"<div><div>Purkinje cells (PCs), the sole output neurons of the cerebellar cortex, are crucial for cerebellum-dependent motor learning. In cerebellar ataxia, reduction in motor function and learning associates with decreased spontaneous activity of PCs. Thus, understanding what molecules regulate PCs activity is important.</div><div>Previously, we demonstrated that a ubiquitous 2-fold increase of endogenous glial cell line-derived neurotrophic factor (GDNF) improves motor function in adult mice and motor learning and coordination in aged mice. However, since GDNF impacts many organ systems the underlying mechanism remained elusive. Here we utilize GDNF Hypermorphic, conditional GDNF Hypermorphic and conditional knock-out mouse models to reveal that up to a 2-fold increase in endogenous GDNF, specifically in PCs postnatally, is sufficient to enhance motor learning. We find that improved motor learning associates with increased glutamatergic input to PCs and with elevated spontaneous firing rate of PCs, opposite to cerebellar ataxia where reduction in motor function and learning associates with decreased spontaneous activity of PCs. Analysis of the human cerebellum revealed that normal interindividual variation in GDNF expression levels falls in the same variation range as studied in the mouse models, suggesting that interindividual variation in PC GDNF levels may contribute to interindividual variation in PC function. Collectively, our findings reveal how a relatively small change in postnatal GDNF expression level within the physiological range in one cell type, the PCs, affects motor learning. Thus, drugs enhancing postnatal GDNF expression in PCs or cerebellar GDNF signaling may have potential in treating cerebellar ataxias, making an interesting topic for future studies.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 27-41"},"PeriodicalIF":2.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0