Neuroscience最新文献

{"title":"Machine learning of connectome-wide functional connectivity in spinal muscular atrophy.","authors":"Yufen Li, Huasong Cai, Mengyu Zhang, Mengzhen Yan, Shasha Lan, Huirong Nie, Wanqing Shen, Cui Yan, Boyan Xu, Yujian Liang, Wen Tang, Yijuan Li, Pei Xiang, Yingqian Chen","doi":"10.1016/j.neuroscience.2026.10.033","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.033","url":null,"abstract":"<p><p>While traditional view posed SMA as a pure motor neuron disorder, accumulating evidence pointed to the broader involvement of central nervous system. This study aimed to combined connectome-wide resting-state functional connectivity with machine learning algorithms to investigate the underlying brain mechanisms in SMA and capture the potential neuroimaging biomarker. Resting-state functional magnetic resonance imaging were acquired from 43 SMA (26 SMA type 2 and 17 type 3) and 45 healthy controls (HCs). Connectome-wide functional connectivity, defined based on the Automated Anatomical Labeling 116 atlas (AAL116), combined with machine learning algorithms including logistic regression (LR), support vector machine (SVM) and random forest (RF) were conducted for SMA vs HCs and SMA type 2 vs 3 classification. SHapley Additive exPlanations (SHAP) algorithm was used to quantify the contribution of individual connections. Connectome-wide functional connectivity allowed individual classification of SMA and HCs with stable performance across machine learning models. The majority of the most discriminative functional connectivity involved the high-level associative regions and cerebellum, subserving sensory and motor processing. Furthermore, the functional connectivity between right superior parietal gyrus and right inferior temporal gyrus was positively correlated with motor function. In conclusion, our study provided connectome-wide evidence that functional connectivity patterns involving high-level associative cortices and the cerebellum could distinguish SMA from HCs using machine learning. The identified connectivity features offer new insight into the distributed brain pathology of SMA beyond the traditional classical motor neuron view, and may serve as promising neuroimaging marker for this disease.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-induced oxidative stress and cGMP depletion suppress cerebellar α2,3-Na⁺,K⁺-ATPase activity in female mice.","authors":"Martina Raissa Ribeiro, Geovanni de Morais Lima, Amanda Siena, Jacqueline Alves Leite, Victoria Francelino Alves, Vitoria Cristina Araujo, André Schmidt Suaiden, Bruno de Souza Gonçalves, Marina Marques Lopes de Morais Toledo, Larissa de Sá Lima, Leandro Augusto Barbosa, Herica de Lima Santos, José Donato Júnior, Tania Marcourakis, Wothan Tavares de Lima, Cristoforo Scavone","doi":"10.1016/j.neuroscience.2026.10.032","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.032","url":null,"abstract":"<p><p>Obesity is a major metabolic disorder linked to neuroinflammation and cognitive decline. Beyond hypothalamic alterations, emerging evidence indicates that extra-hypothalamic regions, including the cerebellum, are vulnerable to obesity-induced neurotoxicity. This study investigated whether high-fat diet (HFD)-induced obesity causes cerebellar oxidative stress, impairs Na⁺,K⁺-ATPase (NKA) activity, and triggers molecular features resembling brain aging in female Balb/C mice. Chronic 10-week HFD intake established a marked obese phenotype, characterized by increased adiposity, fasting hyperglycemia, hyperlipidemia, and elevated serum TNF-α. In the cerebellum, obesity induced a selective, expression-independent reduction in α2,3-NKA isoform activity, accompanied by a marked depletion of tissue cGMP levels. This functional impairment was driven by an oxidative microenvironment, evidenced by elevated H₂O₂ and TBARS levels and increased 4-HNE accumulation. Concomitantly, obese animals mounted an adaptive antioxidant response characterized by increased GST, GR, and GPx activities, reduced glutathione (GSH) consumption, and ERK1/2-mediated nuclear translocation of Nrf2, alongside structural membrane lipid remodeling (elevated cholesterol and reduced phospholipids). In summary, chronic obesity induces robust lipoxidative stress and suppresses cerebellar cGMP signaling and α2,3-NKA activity in female mice, recapitulating key molecular hallmarks of natural brain aging.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zona incerta circuits in cognition and the regulation of sleep and wakefulness: potential relevance to Alzheimer's disease.","authors":"Jun Kang, Yang Li, Wenjun Yan","doi":"10.1016/j.neuroscience.2026.10.030","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.030","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is characterized by progressive cognitive decline and prominent disturbances in sleep and wakefulness, reflecting dysfunction across distributed neural networks. The zona incerta (ZI) is a highly heterogeneous subthalamic structure whose organization is defined by spatial location, molecular identity, neurochemical phenotype, and circuit connectivity. Recent studies demonstrate that distinct ZI cell populations and projections contribute to memory processing, novelty seeking, cortical plasticity, sleep promotion, rapid eye movement (REM) sleep, transitions to wakefulness, and sleep homeostasis. Together, these findings suggest that the ZI is better viewed as a state-dependent subcortical regulatory platform than as a unitary cognitive or sleep center. Emerging pathological evidence further raises the possibility that the ZI may be relevant to neurodegeneration. Amyloid-β deposition has been reported in the ZI of 5xFAD transgenic mice, while experimental tau propagation, human tauopathies other than AD, and studies of other neurodegenerative disorders indicate potential cellular and circuit vulnerability. However, direct evidence from human AD remains lacking, and no study has established a causal pathway from AD pathology to selective ZI dysfunction and subsequent cognitive or sleep impairment. We therefore propose two testable models in which the ZI contributes to AD phenotypes either as a shared circuit node or through parallel, selectively vulnerable functional modules.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAG repeat length shapes bidirectional functional connectome alterations in spinocerebellar ataxia type 3: a multimodal MRI study.","authors":"Xianfei Yang, Haishuo Xia, Yuwei Hu, Can Xu, Xingang Wang, Qingxin Deng, Qian Xie, Limeng Dai, Qifang Yang, Changying Li, Li Gui, Chen Liu","doi":"10.1016/j.neuroscience.2026.10.031","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.031","url":null,"abstract":"<p><p>The ATXN3 gene is the primary driver of brain damage in spinocerebellar ataxia type 3 (SCA3). We aimed to elucidate the patterns of connectome alterations shaped by cytosine-adenine-guanine (CAG) repeat length in SCA3. Eighty-nine genetically confirmed patients with SCA3 and 89 age-, sex-, education-matched healthy controls underwent multimodal MRI and comprehensive clinical assessments. Connectome-based predictive modeling (CPM) was used to identify functional connectivity patterns associated with CAG repeat length. Structural brain damage was assessed using voxel-based morphometry. Mediation analysis was performed to examine the role of structural impairment in connectivity changes. CPM identified a positive and a negative network, whose connectivity strength increased or decreased with CAG repeat length. The positive network (r = 0.397, P < 0.001) was mainly localized within the cerebello-motor circuit and was positively associated with ataxia severity and functional disability. The negative network (r = 0.243, P = 0.022) was distributed across large-scale networks, with selective vulnerability of interhemispheric connectivity, and was associated with motor dysfunction. Besides the canonical motor pathways, limbic-related connectivity was related to motor impairment. Structural analyses revealed widespread gray matter atrophy centered on the cerebellum. Cerebellar atrophy statistically mediated the association between CAG repeat length and connectivity decreases. CAG repeat length is associated with a bidirectional connectopathy in SCA3. Cerebellar atrophy may mediate the connectivity decreases. Future longitudinal studies are required to examine the underlying causal pathway.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabidiol's prosexual effects in sexually active and sexually inhibited male rats.","authors":"Gabriela Rodríguez-Manzo, Ana Canseco-Alba, Jorge Rojas-Hernández","doi":"10.1016/j.neuroscience.2026.10.029","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.029","url":null,"abstract":"<p><p>Cannabidiol (CBD), a non-intoxicating, psychoactive phytocannabinoid, is being explored for its therapeutic potential on a variety of disorders. Marketed as an over-the-counter drug, it is freely available to the public. As a central nervous system acting drug, CBD has the potential to produce sexual effects, especially after its chronic use. This study characterizes the sexual effects of acute and chronic CBD oral treatment in sexually experienced male rats that were either sexually active (n = 8 per group), as a model of optimal copulatory activity, or sexually satiated (n = 8 per group), as a model of inhibited sexual behavior and decreased sexual motivation. Acute administration of CBD to sexually active males produced biphasic, dose-dependent effects on mount and intromission latencies, parameters linked to sexual motivation. In sexually satiated rats, acute treatment with CBD reversed the sexual inhibitory state at a specific dose, which also increased sexual motivation in the sexual incentive motivation test. Chronic treatment (14 days) with low and high doses of CBD did not impair male rat sexual behavior expression in the sexually active male rats. Results show that acute ingestion of CBD has prosexual effects, mainly manifested in sexual motivation, which were particularly evident in the sexually inhibited male rats. CBD chronic treatment did not produce unwanted sexual effects in the sexually active males, suggesting that it does not negatively affect male sexual behavior. The therapeutic potential of acute treatment with CBD for sexual dysfunctions involving motivational deficits should be explored.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating fatigability and cortical activation during prolonged foot tapping in multiple sclerosis.","authors":"Zuhal Abasiyanik, Lousin Moumdjian, Natalia Skorupa, Daphne Kos, Bart van Wijmeersch, Miguel D'Haeseleer, Inge Zijdewind, Peter Feys, Felipe Balistieri Santinelli","doi":"10.1016/j.neuroscience.2026.10.025","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.025","url":null,"abstract":"<p><p>People with multiple sclerosis (pwMS) often exhibit motor fatigability and reduced foot-tapping ability. However, the coupling between performance and cortical activity during fast, repetitive and prolonged ankle movements remains unexplored. We aimed to investigate the neural correlates of a prolonged foot-tap task (FTT) in pwMS and healthy controls (HC). Thirty-nine pwMS (EDSS 4[3.5], 55[14] years) and 18 HC (54.5[9.75) years) performed one 1-minute FTT for each foot. Wearable sensors and functional near-infrared spectroscopy (fNIRS) quantified motor performance and cortical activity, respectively. fNIRS covered bilaterally frontopolar, dorsolateral prefrontal, primary motor (M1) and supplementary motor area cortices. Data were segmented into 10-second intervals and analysed via two-way ANOVA (group × time). Spearman's correlations evaluated associations between changes in cortical activity and performance (6th vs 1st segment). PwMS showed worse FTT performance with lower DLPFC activation compared to HC. On the other hand, comparable FTT performance decline over time were observed in both pwMS and HC. Cortical activity increased in SMA in HC (6 vs 2-3 intervals), but not in pwMS. In HC's, increased cortical activity across all cortical regions in the 6th interval was positive and moderately associated with less worsening in tapping performance. On the other hand, increased M1 activity was weakly associated with less foot tapping in pwMS. PwMS exhibited reduced foot-tap performance, accompanied by reduced DLPFC activation. While increased cortical activity leads to better performance in HC (i.e., a neural compensatory strategy), in pwMS increased activity was associated with worse performance (i.e., neural inefficiency).</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodegenerative diseases in Sub-Saharan Africa: diagnostic invisibility, biological heterogeneity and a precision-neuroscience agenda.","authors":"Maulilio John Kipanyula","doi":"10.1016/j.neuroscience.2026.10.026","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.026","url":null,"abstract":"<p><p>Neurodegenerative diseases (NDs) are increasingly recognised in Sub-Saharan Africa (SSA), but the principal scientific challenge is no longer simply to document a presumed hidden burden. It is to determine how much of the observed heterogeneity reflects underlying neurobiology and how much arises from age structure, case ascertainment, culturally sensitive phenotyping and unequal access to neurological diagnosis. This critical narrative review synthesises evidence from 2000 to July 2026 across epidemiology, disease mechanisms, genomics, biomarkers, environmental exposures, therapeutics and health systems, using Tanzania as an illustrative case rather than a regional proxy. Community studies demonstrate substantial diagnostic invisibility, while recent African-ancestry research shows that inclusion of genetically diverse populations can reveal mechanisms that are poorly captured in ancestry-restricted datasets. The glucosylceramidase beta 1 (GBA1) rs3115534-G Parkinson's disease signal provides a proof of principle, linking an African-ancestry-enriched association to altered ribonucleic acid (RNA) splicing and glucocerebrosidase biology. Emerging plasma biomarkers and ancestry-aware genomics create a route from syndromic diagnosis towards biological characterisation, but thresholds and models require population-specific validation. This review proposes that the next phase of African neurodegeneration research should integrate culturally valid phenotype, biomarkers, imaging, genomics, measured exposures and longitudinal outcomes from inception. Such platforms could distinguish measurement artefact from biological variation, improve regional diagnosis and test the global generalisability of prevailing models of neurodegeneration.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol suppresses intrinsic excitability and alters excitatory synaptic plasticity in ventral tegmental area dopamine neurons.","authors":"Min Hee Lee, Dong Kwan Kim","doi":"10.1016/j.neuroscience.2026.10.028","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2026.10.028","url":null,"abstract":"<p><p>Propofol (2,6-diisopropylphenol) is a short-acting intravenous anesthetic used to induce and maintain general anesthesia. Beyond its anesthetic actions, propofol can produce rewarding subjective effects and has abuse potential. Because ventral tegmental area (VTA) dopamine neurons contribute to reward processing and arousal, we examined the effects of propofol on their intrinsic and excitatory synaptic properties using whole-cell patch-clamp recordings in acute rat midbrain slices. At 100 μM, propofol reduced evoked action-potential firing and increased rheobase in putative VTA dopamine neurons. It also reduced the AMPA/NMDA ratio of glutamatergic synaptic currents. A spike-timing-dependent plasticity (STDP) protocol induced sustained long-term potentiation (LTP) under control conditions, whereas the same protocol in the presence of 100 μM propofol produced persistent LTD-like synaptic depression. These findings show that, under acute slice conditions, propofol alters intrinsic excitability, excitatory synaptic balance, and activity-dependent synaptic plasticity in putative VTA dopamine neurons. Whether these cellular effects contribute to propofol-related arousal or reward behaviors remains to be tested.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal functional lateralization and cooperation in primary angle-closure glaucoma correlate with cell type-specific transcriptional signatures.","authors":"Jing-Wen Qiu, Yuan-Zhi He, Si-Xian Li, Xi-Long Zhang, Xin Huang","doi":"10.1016/j.neuroscience.2026.08.003","DOIUrl":"10.1016/j.neuroscience.2026.08.003","url":null,"abstract":"<p><strong>Background: </strong>Primary angle-closure glaucoma (PACG) damages retinal ganglion cells (RGCs) and is associated with neurodegeneration. This study used resting-state functional magnetic resonance imaging (fMRI) to analyze hemispheric lateralization and cooperative functional alterations in PACG. Machine learning assessed the classification efficacy of neuroimaging indicators, while integrated transcriptomics described spatial relationships between neuroimaging changes and genes, neurotransmitters, and cell types.</p><p><strong>Methods: </strong>Resting-state fMRI data were collected from 101 subjects (44 patients with PACG and 57 controls). Whole-brain maps of the Autonomy Index and connectivity of functional homotopic voxels (CFH) were constructed. Their classification efficacy was assessed using five machine learning classifiers. Partial Least Squares (PLS) spatial correlation analysis examined relationships between neuroimaging maps and gene-transcript profiles, cell type density, and neurotransmitter-receptor distribution maps.</p><p><strong>Results: </strong>PACG showed increased Autonomy Index in cerebellar Crus II and the right paracentral lobule, with widespread reductions in interhemispheric cooperation. Five machine learning models yielded classification results. Image-transcriptome analysis showed that positive Autonomy Index and CFH-positive gene features were enriched in synaptic signaling and neurodevelopment, whereas negative Autonomy Index and CFH-negative gene profiles correlated with neurodegeneration, metabolic dysfunction, and vascular-immune responses. Oligodendrocytes and endothelial cells showed spatial associations with the Autonomy Index and CFH. Brain lateralization and interhemispheric cooperation showed spatial correlations with VAChT topology and several neurotransmitter receptor/transporter maps.</p><p><strong>Conclusion: </strong>PACG is characterized by enhanced cerebral lateralization and diminished interhemispheric cooperation. Explainable machine learning evaluated the classification efficacy of these imaging features. These findings provide a multimodal spatial-association framework relating PACG-related imaging alterations to normative molecular and cellular brain maps.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"94-112"},"PeriodicalIF":3.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early functional disconnection of the basal forebrain-hippocampal system predicts memory impairment in amnestic mild cognitive impairment.","authors":"Juan-Juan Lu, Zhi-Jie Xu, Jie Ma, Jia-Jia Wu, Xin Xue, Xu-Yun Hua, Jian-Guang Xu","doi":"10.1016/j.neuroscience.2026.08.008","DOIUrl":"10.1016/j.neuroscience.2026.08.008","url":null,"abstract":"<p><p>While central remodeling in amnestic mild cognitive impairment (aMCI) is well documented, prevailing studies emphasize whole-brain networks or undirected functional connectivity, largely neglecting specific neuromodulatory systems. We therefore investigated structural integrity and directional effective connectivity within the basal forebrain (BF)-hippocampal-cortical axis to elucidate early pathophysiology. Fifty-one aMCI patients and 67 cognitively healthy controls underwent multimodal MRI and comprehensive neuropsychological assessment. Spectral dynamic causal modeling (spDCM) characterized directional BF-hippocampal connectivity, generalized linear modeling (GLM) identified memory-related BF-cortical circuits, and system dynamics modeling (SDM) quantified pathways linking neural architecture, functional coupling, and cognitive performance. Macroscopic BF and hippocampal volumes did not differ significantly between groups. However, spDCM revealed altered effective connectivity patterns in aMCI patients, characterized by reduced negative effective connectivity. GLM demonstrated that BF-cortical modulation, specifically within medial septum/diagonal band (MS/DB) -parietal circuits, significantly interacted with diagnostic status to predict memory scores. Furthermore, SDM indicated that effective connectivity between the nucleus basalis of Meynert (NBM) and frontoparietal regions significantly predicted NBM structural integrity, which in turn was positively associated with hippocampal volume and long-term memory performance. Collectively, directional connectivity alterations within the BF-hippocampal-cortical axis were observed in patients with aMCI in the absence of detectable macroscopic atrophy, highlighting the potential contribution of BF-related network dysfunction to early disease processes.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"125-134"},"PeriodicalIF":3.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}