Neuroscience最新文献

Thalamocortical dysrhythmia and reward deficiency syndrome as uncertainty disorders. 丘脑皮层节律失常和奖赏缺乏综合征是不确定的疾病。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-05 DOI: 10.1016/j.neuroscience.2024.11.002

Dirk De Ridder, Sven Vanneste

{"title":"Thalamocortical dysrhythmia and reward deficiency syndrome as uncertainty disorders.","authors":"Dirk De Ridder, Sven Vanneste","doi":"10.1016/j.neuroscience.2024.11.002","DOIUrl":"10.1016/j.neuroscience.2024.11.002","url":null,"abstract":"<p><p>A common anatomical core has been described for psychiatric disorders, consisting of the dorsal anterior cingulate cortex (dACC) and anterior insula, processing uncertainty. A common neurophysiological core has been described for other brain related disorders, called thalamocortical dysrhythmia (TCD), consisting of persistent cross-frequency coupling between low and high frequencies. And a common genetic core has been described for yet another set of hypodopaminergic pathologies called reward deficiency syndromes (RDS). Considering that some RDS have the neurophysiological features of TCD, it can be hypothesized that TCD and RDS have a common anatomical core, yet a differentiating associated neurophysiological mechanism. The EEGs of 683 subjects are analysed in source space for both differences and conjunction between TCD and healthy controls, RDS and healthy controls, and between TCD and RDS. A balance between current densities of the pregenual anterior cingulate cortex (pgACC) extending into the ventromedial prefrontal cortex (vmPFC) and dACC is calculated as well. TCD and RDS share a common anatomical and neurophysiological core, consisting of beta activity in the dACC and theta activity in dACC extending into precuneus and dorsolateral prefrontal cortex. TCD and RDS differ in pgACC/vmPFC activity and demonstrate an opposite balance between pgACC/vmPFC and dACC. Based on the Bayesian brain model TCD and RDS can be defined as uncertainty disorders in which the pgACC/vmPFC and dACC have an opposite balance, possibly explained by an inverted-U curve profile of both pgACC/vmPFC and dACC.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing visual motor performance in autistic children based on Kinect and fNIRS: A case study. 基于 Kinect 和 fNIRS 评估自闭症儿童的视觉运动表现：案例研究。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-04 DOI: 10.1016/j.neuroscience.2024.11.001

Yufei Zhao, Lei Zhao, Fei Yang, Chunjing Tao, Weizhong Tang, Wenming Cheng, Yu Zhang, Lingguo Bu

{"title":"Assessing visual motor performance in autistic children based on Kinect and fNIRS: A case study.","authors":"Yufei Zhao, Lei Zhao, Fei Yang, Chunjing Tao, Weizhong Tang, Wenming Cheng, Yu Zhang, Lingguo Bu","doi":"10.1016/j.neuroscience.2024.11.001","DOIUrl":"10.1016/j.neuroscience.2024.11.001","url":null,"abstract":"<p><p>In recent years, the incidence rate of children with autism has shown a significant upward trend. Rehabilitation training is an important part of recovery or improvement in autism children. However, during autism rehabilitation training, the methods that can visually reflect and objectively evaluate its effects are seldom considered. Therefore, this study aimed to objectively evaluate the rehabilitation impact of visual-motor skills training in children with autism via quantitative measures. In this study, vision sensors and functional near-infrared spectroscopy were used to monitor and analyze visual motor training task of 20 autism children. These children were divided into high- and low-score groups according to the autism behavior checklist (ABC). Results showed significant differences between the high- and low-score groups in the brain regions of the left and right temporal lobe, right motor cortex, and left occipital lobe; the difference in functional connectivity was greatest when the left hand was moving at the green light (p < 0.05). The differences in speed, acceleration, and angle between the high- and low-score groups were mainly reflected in left-hand movement. Moreover, analysis of multimodal data showed that visual motor training had a positive effect on brain activation and functional connectivity, and increasing the frequency of left-hand training and using more green light were beneficial to the improvement of brain function. These findings can be used as basis to help optimize rehabilitation programs and improve rehabilitation effectiveness.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the veil of adipokines: A meta-analysis and systematic review in amyotrophic lateral sclerosis. 揭开脂肪因子的面纱：肌萎缩性脊髓侧索硬化症的荟萃分析和系统综述。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-04 DOI: 10.1016/j.neuroscience.2024.11.003

Hamid Abbasi, Neda Jourabchi-Ghadim, Ali Asgarzade, Mobin Mirshekari, Mehrangiz Ebrahimi-Mameghani

{"title":"Unveiling the veil of adipokines: A meta-analysis and systematic review in amyotrophic lateral sclerosis.","authors":"Hamid Abbasi, Neda Jourabchi-Ghadim, Ali Asgarzade, Mobin Mirshekari, Mehrangiz Ebrahimi-Mameghani","doi":"10.1016/j.neuroscience.2024.11.003","DOIUrl":"10.1016/j.neuroscience.2024.11.003","url":null,"abstract":"<p><strong>Background: </strong>Adipokines are proposed to be associated with ALS progression through assorted pathways. Therefore, The present meta-analysis explored the link between various adipokines and ALS progression.</p><p><strong>Method: </strong>International database like PubMed, Scopus, and Web of Science databases were searched to achieve eligible papers published before December 2023. The following PICO structure was utilized: Population (patients with ALS); Intervention (serum concentrations of ghrelin, leptin, and adiponectin), Comparison (with or without controls), and Outcome (ALS progression). the risk of bias of selected papers was assessed through the Newcastle-Ottawa Scale (NOS) tool.</p><p><strong>Results: </strong>11 out of 240 papers were selected for this study which were published between 2010 and 2024. Lower serum leptin concentrations were detected in the ALS compared to control groups (WMD: -0.91, 95% CI:-1.77, -0.05). Serum concentrations of adiponectin were higher in ALS compared to control groups (WMD: 0.41, 95% CI:-0.7, 0.89). Ultimately, The serum concentrations of ghrelin in the ALS groups were lower than control groups (WMD: -1.21, 95% CI: -2.95, 0.53).</p><p><strong>Conclusion: </strong>Our findings revealed that serum concentrations of ghrelin and leptin were higher in ALS patients compared to control, unlike adiponectin.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fecal microbiota transplantation alleviates neuronal Apoptosis, necroptosis and M1 polarization of microglia after ischemic stroke. 粪便微生物群移植可缓解缺血性中风后神经元凋亡、坏死和小胶质细胞的 M1 极化。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-02 DOI: 10.1016/j.neuroscience.2024.10.053

Dingzhi Chen, Jieqiong Xie, Xueyuan Chen, Biyun Qin, Deyan Kong, Jiefeng Luo

{"title":"Fecal microbiota transplantation alleviates neuronal Apoptosis, necroptosis and M1 polarization of microglia after ischemic stroke.","authors":"Dingzhi Chen, Jieqiong Xie, Xueyuan Chen, Biyun Qin, Deyan Kong, Jiefeng Luo","doi":"10.1016/j.neuroscience.2024.10.053","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.10.053","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to delve into the mechanisms underlying the improvement of neurological function in rats with ischemic stroke through fecal microbiota transplantation.</p><p><strong>Methods: </strong>A total of fifty male Sprague-Dawley rats were categorized into three groups: sham surgery, model, and fecal transplantation. We assessed behavioral and pathological alterations in the rats using modified neurological function scoring and TTC staining. Additionally, Western blot and immunofluorescence techniques were employed to examine the expression levels of RIP1, RIP3, MLKL, p-MLKL, Bcl-2, Bax, and cleaved caspase-3 in neurons of ischemic brain tissue, while iNOS and Arg1 were analyzed to evaluate microglial polarization.</p><p><strong>Results: </strong>The fecal transplantation group exhibited a decline in neurological function score compared to the model group, accompanied by a reduction in infarct volume (P < 0.05). Relative to the sham surgery group, the model group displayed a significant increase in the expression levels of necroptosis-related proteins RIP1, RIP3, p-MLKL, apoptotic proteins Bax and cleaved caspase-3, and the M1 microglial cell marker iNOS in ischemic brain tissue, while Bcl-2 expression was notably decreased (P < 0.05). Conversely, compared to the model group, the fecal transplantation group demonstrated decreased expression levels of RIP1, RIP3, p-MLKL, Bax, cleaved caspase-3, and iNOS, along with increased expression of Bcl-2.</p><p><strong>Conclusion: </strong>Fecal microbiota transplantation presents a promising avenue for enhancing neurological function in rats with ischemic stroke by inhibiting neuronal apoptosis, necroptosis, and M1 polarization of microglial cells.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective properties of a thiazolidine-2,4-dione derivative as an inhibitory agent against memory impairment and phosphorylated tau: In vitro and in vivo investigations 噻唑烷-2,4-二酮衍生物作为记忆损伤和磷酸化 tau 抑制剂的神经保护特性：体外和体内研究。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-01 DOI: 10.1016/j.neuroscience.2024.10.054

{"title":"Neuroprotective properties of a thiazolidine-2,4-dione derivative as an inhibitory agent against memory impairment and phosphorylated tau: In vitro and in vivo investigations","authors":"","doi":"10.1016/j.neuroscience.2024.10.054","DOIUrl":"10.1016/j.neuroscience.2024.10.054","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is the most common form of neurodegeneration that results in memory disorders and cognitive impairment. The present study investigated the neuroprotective effects of the synthesized thiazolidine-2,4-dione derivative, (E)-5-(4-chlorobenzylidene)-3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione (TZ4C), an inhibitor of p-Tau and memory impairment, using a SH-SY5Y cell model of methamphetamine-induced tauopathy and a scopolamine-induced memory impairment model in Wistar rats.</div><div>In the present study, the neuroprotective effect of TZ4C was studied in a SH-SY5Y cellular model of methamphetamine-induced (2 mM) tauopathy and a scopolamine-induced (1.5 mg/kg/day) memory impairment model in male Wistar rats (n = 48). The memory functions and learning abilities of the rats were evaluated using the Morris water maze (MWM) and passive avoidance tests. Additionally, AChE activity in the rat hippocampus was quantified, and the expression of p-Tau, HSP70, and caspase-3 in both <em>in vitro</em> and <em>in vivo</em> samples was evaluated through Western blot analysis.</div><div>TZ4C (0.1–1000 µM) did not exhibit significantly toxic effects on SH-SY5Y cell viability. Western blot results indicated that TZ4C led to reduced expression of p-Tau, HSP70, and cleaved caspase-3 in SH-SY5Y cells (3 and 10 µM) and the rat hippocampus (2 and 4 mg/kg). Additionally, the findings suggested that TZ4C enhanced memory function in rats with scopolamine-induced impairment and decreased acetylcholinesterase (AChE) specific activity.</div><div>The comprehensive analysis of <em>in vitro</em> and <em>in vivo</em> experiments underscores the neuroprotective potential (improved neuropathology and reduced memory impairment) of TZ4C. These findings highlight the promise of TZ4C as a candidate for drug discovery programs to identify effective therapies for AD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological activities and therapeutic potential of Hyperoside in the treatment of Alzheimer's and Parkinson's diseases: A systemic review. 金丝桃苷在治疗阿尔茨海默氏症和帕金森氏症方面的药理活性和治疗潜力：系统综述。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-01 DOI: 10.1016/j.neuroscience.2024.10.048

Jiayu Yuan, Xiaoyu Dong, Siyu Zhou, Jianfei Nao

{"title":"Pharmacological activities and therapeutic potential of Hyperoside in the treatment of Alzheimer's and Parkinson's diseases: A systemic review.","authors":"Jiayu Yuan, Xiaoyu Dong, Siyu Zhou, Jianfei Nao","doi":"10.1016/j.neuroscience.2024.10.048","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.10.048","url":null,"abstract":"<p><p>Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders that significantly impact well-being. Hyperoside (HYP), a flavonoid found in various plant species, particularly within the genus Hypericin, exhibits diverse pharmacological properties. However, the precise mechanisms underlying the anti-AD and anti-PD effects of HYP remain unclear. This systematic review consolidated existing preclinical research on HYP by conducting a comprehensive literature survey and analysis. The objective was to corroborate the therapeutic efficacy of HYP in AD and PD models and to synthesize its potential therapeutic mechanisms. Searches were conducted in the PubMed, CNKI, and Web of Science databases. Reliability assessment of the 17 included studies confirmed the credibility of the mechanisms of action of HYP against AD and PD. We systematically assessed the neuroprotective potential of HYP in in vivo and in vitro models of AD and PD. Our findings indicated that HYP can mitigate, intervene in, and treat AD and PD animal models and associated cells through various mechanisms, including anti-oxidative, anti-inflammatory, anti-apoptotic, anti-Aβ aggregation, and cholinesterase inhibitory activities. Therefore, HYP potentially exerts anti-AD and anti-PD effects through diverse mechanisms, making it a promising candidate for therapeutic intervention in both AD and PD.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative transcriptional analyses of the striatum in the chronic social defeat stress model in C57BL/6J male mice and the gut microbiota-dysbiosis model in Kumming mice C57BL/6J雄性小鼠慢性社会挫败应激模型与 Kumming 小鼠肠道微生物群-菌群失调模型中纹状体的转录比较分析。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-01 DOI: 10.1016/j.neuroscience.2024.10.057

{"title":"Comparative transcriptional analyses of the striatum in the chronic social defeat stress model in C57BL/6J male mice and the gut microbiota-dysbiosis model in Kumming mice","authors":"","doi":"10.1016/j.neuroscience.2024.10.057","DOIUrl":"10.1016/j.neuroscience.2024.10.057","url":null,"abstract":"<div><div>Depression is a complex disorder with multiple contributing factors, and chronic stress has previously been recognized as a major causative factor, while gut microbes have also been found to be involved in depression recently. However, gene expression in depression models with different etiologies is unclear. Here, we compared the transcriptomes of the striatum in chronic social defeat stress (CSDS) model of C57BL/6J male mice and fecal microbiota transplant (FMT) model of Kumming male mice. We found that the proportion of shared differentially expressed genes (DEGs) between the two models was only 24 %. The specific DEGs of FMT model were enriched in immune and inflammatory, and are associated with changes in vascular and ciliated ependymal cells. The specific DEGs of CSDS model were enriched in neuron and synapse. The results of network analysis suggested the expression patterns and biological function of depressive-like behaviors-related modules in the two models are different. Further, the alternative splicing events of CSDS are more than FMT. Our results suggested models of depression induced by different etiologies differ significantly in gene expression and biological function. Our study also suggested us to pay attention to the characteristics of models of depression of different etiologies and provided a more comprehensive understanding of the heterogeneity of depression.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mTOR signaling pathway as a pathophysiologic mechanism in preclinical models of autism spectrum disorder. 自闭症谱系障碍临床前模型中作为病理生理机制的 mTOR 信号通路。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-10-30 DOI: 10.1016/j.neuroscience.2024.10.050

Isabela Drehmer, Júlio Santos-Terra, Carmem Gottfried, Iohanna Deckmann

{"title":"mTOR signaling pathway as a pathophysiologic mechanism in preclinical models of autism spectrum disorder.","authors":"Isabela Drehmer, Júlio Santos-Terra, Carmem Gottfried, Iohanna Deckmann","doi":"10.1016/j.neuroscience.2024.10.050","DOIUrl":"10.1016/j.neuroscience.2024.10.050","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a highly prevalent multifactorial disorder characterized by social deficits and stereotypies. Despite extensive research efforts, the etiology of ASD remains poorly understood. However, studies using preclinical models have identified the mechanistic target of rapamycin kinase (mTOR) signaling pathway as a key player in ASD-related features. This review examines genetic and environmental models of ASD, focusing on their association with the mTOR pathway. We organize findings on alterations within this pathway, providing insights about the potential mechanisms involved in the onset and maintenance of ASD symptoms. Our analysis highlights the central role of mTOR hyperactivation in disrupting autophagic processes, neural organization, and neurotransmitter pathways, which collectively contribute to ASD phenotypes. The review also discusses the therapeutic potential of mTOR pathway inhibitors, such as rapamycin, in mitigating ASD characteristics. These insights underscore the importance of the mTOR pathway as a target for future research and therapeutic intervention in ASD. This review innovates by bringing the convergence of disrupted mTOR signaling in preclinical models and clinical data associated with ASD.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell surface receptor-mediated signaling in CNS regeneration 中枢神经系统再生过程中细胞表面受体介导的信号传导。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-10-30 DOI: 10.1016/j.neuroscience.2024.10.049

{"title":"Cell surface receptor-mediated signaling in CNS regeneration","authors":"","doi":"10.1016/j.neuroscience.2024.10.049","DOIUrl":"10.1016/j.neuroscience.2024.10.049","url":null,"abstract":"<div><div>Degenerative diseases and injuries of central nervous system (CNS) often cause nerve cell apoptosis and neural dysfunction. Protection of surviving cells or inducing the differentiation of stem cells into functional cells is considered to be an important way of neurorepair. In addition, transdifferentiation technology emerged recently is expected to provide new solutions for nerve regeneration. Cell surface receptors are transmembrane proteins embedded in cytoplasmic membrane, and play crucial roles in maintaining communication between extracellular signals and intracellular signaling processes. The extracellular microenvironment changed dramatically upon neural lesion, exploring the biological function of signals mediated by cell surface receptors will help to develop molecular strategies for nerve regeneration. An increasing number of studies have reported that cell surface receptor-mediated signaling affects the survival, differentiation, and functioning of neural cells, and even regulate their <em>trans</em>-lineage reprogramming. Here, we provide a review on the roles of cell surface receptors in CNS regeneration, thus providing new cues for better treatment of neurodegenerative diseases or nerve injury.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective blockade of cannabinoid receptors influence motoneuron survival and glial reaction after neonatal axotomy. 选择性阻断大麻素受体会影响新生儿轴突切断术后运动神经元的存活和神经胶质的反应。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-10-29 DOI: 10.1016/j.neuroscience.2024.10.051

Matheus Perez, Aline Barroso Spejo, Gabriela Bortolança Chiarotto, Francisco Silveira Guimarães, Alexandre Leite Rodrigues de Oliveira, Luciana Politti Cartarozzi

{"title":"Selective blockade of cannabinoid receptors influence motoneuron survival and glial reaction after neonatal axotomy.","authors":"Matheus Perez, Aline Barroso Spejo, Gabriela Bortolança Chiarotto, Francisco Silveira Guimarães, Alexandre Leite Rodrigues de Oliveira, Luciana Politti Cartarozzi","doi":"10.1016/j.neuroscience.2024.10.051","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.10.051","url":null,"abstract":"<p><p>Sciatic nerve crush in neonatal rats leads to an extensive death of motor and sensory neurons, serving as a platform to develop new neuroprotective approaches. The endocannabinoid system plays important neuromodulatory roles and has been involved in neurodevelopment and neuroprotection. The present work investigated the role of the cannabinoid receptors CB1 and CB2 in the neuroprotective response after neonatal axotomy. CB1 and CB2 antagonists (AM251 and AM630, respectively) were used after sciatic nerve crush in 2-day-old Wistar rats. Five days after lesion and treatment, the rats were perfused, and the spinal cords and dorsal root ganglia (DRG) were obtained and processed to investigate neuronal survival and immunohistochemistry changes, or RT-qPCR analysis. Motoneuron survival analysis showed that blocking CB2 alone or in combination with CB1 was neuroprotective. This effect was associated with a decrease in astrogliosis and microglial reaction. Interestingly, Cnr1 (CB1) and Bdnf gene transcripts were downregulated in the spinal cords of the antagonist-treated groups. Despite no intergroup difference regarding neuronal survival in the DRG, the simultaneous blockade of CB1 and CB2 receptors led to an increased expression of both Cnr1 and Cnr2, combined with Gdnf upregulation. The results indicate that the selective antagonism of cannabinoid receptors facilitates neuroprotection and decreases glial reactivity, suggesting new potential treatment approaches.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0