Neuroscience最新文献

Serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury.

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-27 DOI: 10.1016/j.neuroscience.2024.11.066

Gengfan Ye, Zhigang Wang, Pandi Chen, Junyi Ye, Shiwei Li, Maosong Chen, Jiugeng Feng, Hongcai Wang, Wei Chen

{"title":"Serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury.","authors":"Gengfan Ye, Zhigang Wang, Pandi Chen, Junyi Ye, Shiwei Li, Maosong Chen, Jiugeng Feng, Hongcai Wang, Wei Chen","doi":"10.1016/j.neuroscience.2024.11.066","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.066","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) induces significant neuroinflammation, primarily driven by microglia. Neonatal microglia (NMG) may have therapeutic potential by modulating the inflammatory response of damaged adult microglia (AMG). This study investigates the influence of NMG on AMG function through extracellular matrix (ECM) remodeling and the formation of tunneling nanotubes (TnTs), with a focus on the role of Serpina3n. We established an in vitro TBI model using a 3D Transwell system, co-culturing damaged AMG with NMG. Viral vector transfection was employed to manipulate Serpina3n expression in NMG. Quantitative real-time PCR, Western blotting, and ELISA were utilized to assess inflammatory markers, ECM remodeling proteins, and TnTs-related proteins. Co-culturing with NMG significantly inhibited M1 polarization of AMG and reduced the release of pro-inflammatory cytokines while promoting M2 polarization and increasing the production of anti-inflammatory cytokines. NMG expressed higher levels of Serpina3n, which played a crucial role in reducing Granzyme B, matrix metalloproteinase (MMP) 2 and MMP9 expression, thereby mitigating ECM remodeling. Inhibition of Serpina3n in NMG increased pro-inflammatory markers and decreased TnTs formation proteins, whereas overexpression of M-sec in AMG counteracted these effects. This highlights the importance of TnTs in maintaining microglial function and promoting an anti-inflammatory environment. In conclusion, NMG improve the function of damaged AMG by modulating ECM remodeling and promoting TnTs formation through the action of Serpina3n.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders.

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-26 DOI: 10.1016/j.neuroscience.2024.11.055

Mayur B Kale, Nitu L Wankhede, Ashok Kumar Bishoyi, Suhas Ballal, Rishiv Kalia, Renu Arya, Sachin Kumar, Mohammad Khalid, Monica Gulati, Mohit Umare, Brijesh G Taksande, Aman B Upaganlawar, Milind J Umekar, Spandana Rajendra Kopalli, Mohammad Fareed, Sushruta Koppula

{"title":"Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders.","authors":"Mayur B Kale, Nitu L Wankhede, Ashok Kumar Bishoyi, Suhas Ballal, Rishiv Kalia, Renu Arya, Sachin Kumar, Mohammad Khalid, Monica Gulati, Mohit Umare, Brijesh G Taksande, Aman B Upaganlawar, Milind J Umekar, Spandana Rajendra Kopalli, Mohammad Fareed, Sushruta Koppula","doi":"10.1016/j.neuroscience.2024.11.055","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.055","url":null,"abstract":"<p><p>Plethora of research has shed light on the critical role of synaptic dysfunction in various neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). Synapses, the fundamental units for neural communication in the brain, are highly vulnerable to pathological conditions and are central to the progression of neurological diseases. The presynaptic terminal, a key component of synapses responsible for neurotransmitter release and synaptic communication, undergoes structural and functional alterations in these disorders. Understanding synaptic transmission abnormalities is crucial for unravelling the pathophysiological mechanisms underlying neurodegeneration. In the quest to probe synaptic transmission in NDDs, emerging biophysical techniques play a pivotal role. These advanced methods offer insights into the structural and functional changes occurring at nerve terminals in conditions like AD, PD, HD & ALS. By investigating synaptic plasticity and alterations in neurotransmitter release dynamics, researchers can uncover valuable information about disease progression and potential therapeutic targets. The review articles highlighted provide a comprehensive overview of how synaptic vulnerability and pathology are shared mechanisms across a spectrum of neurological disorders. In major neurodegenerative diseases, synaptic dysfunction is a common thread linking these conditions. The intricate molecular machinery involved in neurotransmitter release, synaptic vesicle dynamics, and presynaptic protein regulation are key areas of focus for understanding synaptic alterations in neurodegenerative diseases.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differential effects of early maternal separation on PTSD susceptibility in adult rats accompanied by telomere shortening in the hippocampus 早期母体分离对成年大鼠创伤后应激障碍易感性的性别差异影响伴随着海马端粒的缩短。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-26 DOI: 10.1016/j.neuroscience.2024.11.058

Yue Teng , Yuan Gao , Lijun Liu , Wendi Zhang , Changjiang Li , Bo Lian , Hongwei Sun , Lin Sun

{"title":"Sex differential effects of early maternal separation on PTSD susceptibility in adult rats accompanied by telomere shortening in the hippocampus","authors":"Yue Teng , Yuan Gao , Lijun Liu , Wendi Zhang , Changjiang Li , Bo Lian , Hongwei Sun , Lin Sun","doi":"10.1016/j.neuroscience.2024.11.058","DOIUrl":"10.1016/j.neuroscience.2024.11.058","url":null,"abstract":"<div><div>Early life stress (ELS) is thought to be a leading cause of mental disorders in adulthood, including PTSD. Recent studies have found that such stress has a gender and resilient specific effect on adult PTSD. This study aimed to assess emotion, and cognitive behavior, and to examine the sex differences and resilience of ELS on adult PTSD. At the same time, the expression of hippocampal telomere length and telomere repeat binding factors (TRF1 and TRF2) were detected to explore the mechanism of telomere length change. Rat offspring were separated from their dams (3 h/day or 6 h/day from PND2 ∼ PND14). Then, pups were treated with a single prolonged stress (SPS) procedure when they reached adulthood (PND80). Rats exposed early to MS and SPS showed anxiety-like and depression-like behaviors as well as impaired learning and memory. The rats exposed to MS3h showed reduced anxiety-like and depression-like behavior upon re-experiencing “secondary stress” compared to the SPS and MS6h groups. Behavioral results showed no significant gender difference. However, gender and SPS factors significantly affected telomere length and TRF1 and TRF2 gene expression in hippocampus. The SPS effect and MS*SPS interaction significantly impacted TRF1 and TRF2 protein expression. In conclusion, this study shows that MS has different effects on anxiety, depression, and cognitive memory deficits in rats experiencing “secondary stress” in adulthood and is accompanied by telomere shortening in the hippocampus. This reveals the potential impact of early MS on PTSD and provides a new perspective for further research in the field of psychological stress.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"564 ","pages":"Pages 281-289"},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immunomodulatory effects of psychedelics in Alzheimer’s disease-related dementia 迷幻药对阿尔茨海默氏症相关痴呆症的免疫调节作用。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-26 DOI: 10.1016/j.neuroscience.2024.11.062

Alireza Mohammad Hosseini , Hossein Khaleghzadeh‐Ahangar , Atena Rahimi

引用次数: 0

Deciphering the peculiarities of cell types in the septum. 解密隔膜细胞类型的特殊性。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-25 DOI: 10.1016/j.neuroscience.2024.11.063

Michael Trojan, Dominik Kanigowski, Łukasz Bijoch, Martyna Pękała, Diana Legutko, Anna Beroun, Marek Bekisz, Luis V Colom, Sodikdjon A Kodirov

{"title":"Deciphering the peculiarities of cell types in the septum.","authors":"Michael Trojan, Dominik Kanigowski, Łukasz Bijoch, Martyna Pękała, Diana Legutko, Anna Beroun, Marek Bekisz, Luis V Colom, Sodikdjon A Kodirov","doi":"10.1016/j.neuroscience.2024.11.063","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.063","url":null,"abstract":"<p><p>Similar to other brain regions, the neurons in the lateral septum (LS) are of heterogeneous populations. However, their resting membrane potential (RMP) on average is not too far apart. Cells were characterized based on biological markers by using brain slices, as under these in vitro conditions, neurons retain their morphologies. Since the LS neurons are not spontaneously excitable at RMP, the action potentials (APs) were evoked via injections of currents of moderate magnitude. In coronal brain slices of rats, a smaller portion of neurons generated a train of APs of complex nature. In order to define the types of neurons with similar phenotypes, we subsequently used the four lines of td-Tomato transgenic mice. The brains of these mice express the promoter fluorophore td-Tomato and enhanced green fluorescent protein (eGFP). Therefore, recordings were conducted in a targeted manner in neurons expressing glutamic acid decarboxylase (GAD), parvalbumin (PV), somatostatin (SOM), or vasoactive intestinal polypeptide (VIP). Similar spike phenotypes that we refer to as type III, in order to distinguish from AP in principal cells - type I and those in interneurons - type II, also exist in mice, substantiating a similitude among rodents. The type III AP is selectively triggered by Ca<sup>2+</sup> in GAD and SOM-positive neurons. Conclusions are supported by established pharmacologic tools, nimodipine, TTX, and ZD7288, a selective HCN channel antagonist.Collectively, these observations revitalize our knowledge from pioneering studies with regard to the brain of mammals in general and septal structures in particular.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proprioceptive acuity for locating and controlling movements of a hand-held tool. 定位和控制手持工具移动的直觉敏锐度。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-25 DOI: 10.1016/j.neuroscience.2024.11.048

Warren G Darling, Bennett I Zuck

{"title":"Proprioceptive acuity for locating and controlling movements of a hand-held tool.","authors":"Warren G Darling, Bennett I Zuck","doi":"10.1016/j.neuroscience.2024.11.048","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.048","url":null,"abstract":"<p><p>We investigated proprioceptive acuity for location and motion of a never seen hand-held tool (30 cm long rod) and the accuracy of movements to place tool parts in the location of remembered visual targets. Ten blindfolded right-handed subjects (5 females) reached with the tool held in the right hand to touch the tip and midpoint to the stationary and moving left index-tip, to the right and left ear lobes and to remembered visual target locations. We also tested accuracy of left hand rod reaches to the ear lobes to determine if rod dimensions and control of tool movements experienced during right hand tool use could be used to accurately localize the rod parts when held in the left hand. Errors for right hand-held rod-tip movements to touch the stationary and moving left index-tip averaged only about 1 cm larger than observed previously for right hand movements to touch its index-tip to the left index-tip. The tool-tip was localized with lower mean distance errors (about 1 cm) than the tool-midpoint (5.5-6.5 cm) when reaching to touch the ear lobes with the rod in right and left hands. Right hand reaches to place the tool- tip and midpoint in remembered visual target locations were inaccurate with large overshoots of close targets and undershoots of far targets, similar to previous reports for reaching with the right hand to remembered visual targets. These results support the distalization hypothesis, that tool the tool endpoint becomes the effective upper limb endpoint when using the tool.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dihydromyricetin ameliorates neurotoxicity induced by high glucose through restraining ferroptosis by inhibiting JNK-inflammation pathway in HT22 cells. 二氢杨梅素通过抑制 HT22 细胞中的 JNK-炎症通路，抑制铁突变，从而改善高糖诱导的神经毒性。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-25 DOI: 10.1016/j.neuroscience.2024.11.061

Li-Ting Peng, Meng-Wei Li, Zhen-Jiang Song, Qi Li, Ke-Bin Zhan, Can-Qun Yan, Hong-Yan Ling

{"title":"Dihydromyricetin ameliorates neurotoxicity induced by high glucose through restraining ferroptosis by inhibiting JNK-inflammation pathway in HT22 cells.","authors":"Li-Ting Peng, Meng-Wei Li, Zhen-Jiang Song, Qi Li, Ke-Bin Zhan, Can-Qun Yan, Hong-Yan Ling","doi":"10.1016/j.neuroscience.2024.11.061","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.061","url":null,"abstract":"<p><p>Diabetes mellitus is recognized as an important cause of cognitive dysfunction. Ferroptosis plays a key role in diabetic cognitive dysfunction (DCD). Dihydromyricetin (DHM) has promising neuronal protective effects, but it is unclear the mechanism. Here, the effects of DHM on HG-induced neurotoxicity in HT22 cells and its molecular mechanisms were investigated. Our results demonstrated that the viability of HG (125 mmol/L)-induced HT22 cells was significantly decreased. Furthermore, ferroptosis-related indicators, c-Jun N-terminal kinase (JNK)-inflammatory pathway, TNF-α, IL-1β, and mitochondrial morphology were measured. The results show that mitochondria of HT22 cells also showed wrinkled alterations in response to HG treatment. Meanwhile, the levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) were decreased, accompanied by an up-regulation of malondialdehyde (MDA), Fe<sup>2+</sup>, acyl-CoA synthetase long-chain family member 4 (ACSL4), and reactive oxygen species (ROS), indicating ferroptosis occurred in HG-induced HT22 cells. Furthermore, the levels of p-JNK, TNF-α, and IL-6 were up-regulated in HG-induced HT22 cells. DHM or JNK inhibitor SP600125 reversed these changes in HG-induced HT22 cells indicating that HG-induced neurotoxicity in HT22 cells may be associated with ferroptosis induced by the JNK-inflammatory factor pathway. Meanwhile, JNK agonist Anisomycin could attenuate these effects of DHM. Taken together, our data suggest that DHM can ameliorate HG-induced neurotoxicity in HT22 cells by inhibiting ferroptosis via the JNK-inflammatory signaling pathway. Hence, DHM may represent a novel and promising therapeutic intervention for DCD.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of PIK3CG knockdown against OGD/R-induced neuronal damage via inhibition of autophagy through the AMPK/mTOR pathway. 通过AMPK/mTOR途径抑制自噬，PIK3CG敲除对OGD/R诱导的神经元损伤具有保护作用。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-25 DOI: 10.1016/j.neuroscience.2024.11.064

Luting Lv, Jiayi Qian, Junzhi Sang, Jie Li, Tingting Liu

{"title":"Protective effects of PIK3CG knockdown against OGD/R-induced neuronal damage via inhibition of autophagy through the AMPK/mTOR pathway.","authors":"Luting Lv, Jiayi Qian, Junzhi Sang, Jie Li, Tingting Liu","doi":"10.1016/j.neuroscience.2024.11.064","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.064","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke represents an urgent need for more efficacious therapies owing to modest effectiveness of current treatment.</p><p><strong>Methods: </strong>Download data from stroke patients and collect blood samples from clinical patients to analyze phosphatidylinositol-3 kinase catalytic subunit γ (PIK3CG) expression. To establish a brain damage model, oxygen glucose deprivation/reperfusion (OGD/R) was applied to SH-SY5Y cells. Impact of PIK3CG on AMPK/mTOR autophagy pathway was verified treating cells with AMPK activator metformin. Proliferation and apoptosis were identified by CCK8 and flow cytometry.</p><p><strong>Results: </strong>Differential expression analysis and clinical testing show that PIK3CG is highly expressed in patients. Prolonged ODG/R exposure increased PIK3CG levels, supressed cell proliferation, and induced apoptosis. KEGG pathway analysis implicated PIK3CG in autophagy pathway. Knockdown of PIK3CG supressed OGD/R-induced reductions in cell proliferation and OGD/R-induced increases in apoptosis and expressions of Beclin 1 and LC3 II. Following OGD/R, AMPK phosphorylation was upregulated while mammalian target of rapamycin (mTOR) phosphorylation was downregulated, indicating AMPK/mTOR autophagy activation. Knockdown of PIK3CG opposed metformin-induced rises in Beclin 1, LC3 II and apoptosis along with decreases in proliferation.</p><p><strong>Conclusion: </strong>PIK3CG knockdown protects neuronal cells by inhibiting AMPK/mTOR autophagy pathway and further inhibiting autophagy.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain structural and functional changes in patients with chronic heart failure. 慢性心力衰竭患者大脑结构和功能的变化。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-25 DOI: 10.1016/j.neuroscience.2024.11.060

Yu Ting Liu, Yu Ting Yang, Chun Xiang Tang, Jun Qing Ma, Xiang Kong, Jian Hua Li, Yan Ming Li, Shu Yu Liu, Chang Sheng Zhou, Long Jiang Zhang

{"title":"Brain structural and functional changes in patients with chronic heart failure.","authors":"Yu Ting Liu, Yu Ting Yang, Chun Xiang Tang, Jun Qing Ma, Xiang Kong, Jian Hua Li, Yan Ming Li, Shu Yu Liu, Chang Sheng Zhou, Long Jiang Zhang","doi":"10.1016/j.neuroscience.2024.11.060","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.060","url":null,"abstract":"<p><p>Heart failure (HF) frequently suffers from brain abnormalities and cognitive impairments. This study aims to investigate brain structure and function alteration in patients with chronic HF. This retrospective study included 49 chronic HF and 49 health controls (HCs). Voxel-based morphometry was conducted on structural MRI to quantify gray matter volume (GMV), and functional connectivity (FC) was assessed with seed-based analysis using resting-state fMRI. White matter microstructure integrity was also evaluated through tract-based spatial statistics employing DTI. Correlations between multimodal MRI features and cognitive performance were further investigated in patients with chronic HF. Patients with chronic HF exhibited significantly reduced regional GMV, white matter microstructure injury (Family wise error correction, p＜0.05), and decreased FC in multiple brain regions involved in cognition, sensorimotor, visual function (Gaussian random field correction, voxel level p＜0.0001 and cluster-level p＜0.01). There was no observed increases in GMV or FC compared with HCs. Decreased GMV showed positive correlations with cognitive performance (r = 0.025-0.577, p = 0.025-0.001), while decreased fractional anisotropy was negatively correlated with anxiety scores (r = -0.339, p = 0.040) in patients with chronic HF. This study revealed that patients with chronic HF exhibited brain structure injury affecting gray matter and white matter, as well as FC abnormalities of brain regions responsible for cognition, sensorimotor and visual function. These findings suggest GMV could serve as a neuroimaging biomarker for cognitive impairments and a potential target for neuroprotective therapies in patients with chronic HF.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and temporal patterns of brain neural activity mediating human thermal sensations 介导人类热感觉的大脑神经活动的空间和时间模式。

IF 2.9 3区医学

Neuroscience Pub Date : 2024-11-24 DOI: 10.1016/j.neuroscience.2024.11.045

Hironori Watanabe , Satoshi Shibuya , Yuta Masuda , Taisuke Sugi , Kiyoshi Saito , Kei Nagashima

{"title":"Spatial and temporal patterns of brain neural activity mediating human thermal sensations","authors":"Hironori Watanabe , Satoshi Shibuya , Yuta Masuda , Taisuke Sugi , Kiyoshi Saito , Kei Nagashima","doi":"10.1016/j.neuroscience.2024.11.045","DOIUrl":"10.1016/j.neuroscience.2024.11.045","url":null,"abstract":"<div><div>This study aimed to elucidate the spatial and temporal patterns of brain neural activity that are associated with cold and hot sensations. Participants (n = 20) sat in a controlled room with their eyes closed and received local thermal stimuli to the right fingers using a Peltier apparatus. The thermal stimuli were repeated 40 times using a paired-thermal stimulus paradigm, comprising a 15 s-reference stimulus (32 °C), followed by 10 s-conditioned stimuli (24 °C and 40 °C, cold and hot conditions, respectively), for which 15-channel electroencephalography (EEG) signals were continuously monitored. To identify the patterns of brain neural activity, an independent component (IC) analysis was applied to the preprocessed EEG data. The equivalent current dipole locations were estimated, followed by clustering of the ICs with a dipole residual variance of <15 %. Subsequently, event-related spectral perturbations were analyzed in each identified cluster to calculate the power changes across specific frequency ranges. The right precentral gyrus, precuneus, medial frontal gyrus, middle frontal gyrus, superior frontal gyrus, cuneus, cingulate gyrus, left precentral gyrus, middle occipital gyrus, and cingulate gyrus were activated in both cold and hot conditions. In most activated regions, EEG power temporal changes were observed across the frequency ranges and were different between the two conditions. These results may suggest that cold and hot sensations are processed through different temporal brain neural activity patterns in overlapping brain regions.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"564 ","pages":"Pages 260-270"},"PeriodicalIF":2.9,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0