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Transcriptomic analysis reveals potential targets associated with hippocampus vulnerability in spatial cognitive dysfunctionof type 2 diabetes mellitus rats. 转录组学分析揭示了与2型糖尿病大鼠空间认知功能障碍海马易感性相关的潜在靶点。
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-25 DOI: 10.1016/j.neuroscience.2025.05.036
Ying Zhang, Dongmei Su, Yuru Liu, Bin He, Huiping Wang, Cuige Shi, Yishu Yang
{"title":"Transcriptomic analysis reveals potential targets associated with hippocampus vulnerability in spatial cognitive dysfunctionof type 2 diabetes mellitus rats.","authors":"Ying Zhang, Dongmei Su, Yuru Liu, Bin He, Huiping Wang, Cuige Shi, Yishu Yang","doi":"10.1016/j.neuroscience.2025.05.036","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.05.036","url":null,"abstract":"<p><strong>Background: </strong>Cognitive dysfunction is one of the major complications of T2DM.However, the precise molecular mechanism underlying this relationship remains unclear. Present study aimed to identify potential predictors of cognitive dysfunction associated with T2DM specifically within the hippocampus.</p><p><strong>Methods: </strong>T2DM was induced by a high-fat diet combined with streptozotocin injections. Morris water maze was employed to assess spatial cognitive ability. HE staining was used to evaluate neurons injury in hippocampus. Transcriptome sequencing was conducted on the hippocampus to identify potential genes. The results obtained from sequencing analysis werevalidated using qRT-PCR. GO and KEGG analyses were performed to investigate the functions of differentially expressed genes (DEGs) and their associated biological pathways.</p><p><strong>Results: </strong>Compared with CON rats, thespatial cognitive ability decreased in T2DM rats. Hippocampus neurons reduced in CA1 area of T2DM rats. In total, 123 DEGswere identified bytranscriptome sequencing, including 25 upregulated genes and 98 downregulated genes. The qRT-PCR results verified the RNA-seq. KEGG pathway analysis showed the major enriched pathways were TNF signaling pathway, arachidonic acid metabolism, AGE-RAGE signaling pathway in diabetic complications, and cellular senescence. GO analysis showed that DEGs involved in biological process were mainly related to vasculogenesis, response to hypoxia, regulation of cell proliferation and aging.</p><p><strong>Conclusions: </strong>Our transcriptomic analysis reveals the \"cellular senescence\" signaling pathway may be implicated in T2DM-induced spatial cognitive dysfunction and Tgfbr2 may be the important DEG involved in this pathway, which will be the primary focus of our future research endeavors.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated multi-omics analysis reveals immunovascular mechanisms of the placenta-maternal brain axis and lifespan neurobehavior changes in a mouse model of preeclampsia. 综合多组学分析揭示了胎盘-母体脑轴的免疫血管机制和子痫前期小鼠模型的寿命神经行为变化。
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-24 DOI: 10.1016/j.neuroscience.2025.05.301
Serena Gumusoglu, Brianna Blaine, Aimee Bertolli, Matthew A Weber, Mushroor Kamal, Hannah Hazzard, Brandon Schickling, Marisol Lauffer, Yuping Zhang, Robert Taylor, Keagan Kirkpatrick, Donna Santillan, Georgina Aldridge, Mark Santillan
{"title":"Integrated multi-omics analysis reveals immunovascular mechanisms of the placenta-maternal brain axis and lifespan neurobehavior changes in a mouse model of preeclampsia.","authors":"Serena Gumusoglu, Brianna Blaine, Aimee Bertolli, Matthew A Weber, Mushroor Kamal, Hannah Hazzard, Brandon Schickling, Marisol Lauffer, Yuping Zhang, Robert Taylor, Keagan Kirkpatrick, Donna Santillan, Georgina Aldridge, Mark Santillan","doi":"10.1016/j.neuroscience.2025.05.301","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.05.301","url":null,"abstract":"<p><p>Preeclampsia (PE) is a hypertensive disorder of pregnancy, among the leading global drivers of maternal morbidity. PE can precipitate neuropsychiatric risk, including for peripartum anxiety, depression, and cognitive problems. To investigate mechanisms underlying psycho-obstetric risk in PE, we examined maternal metabolic, placental, brain, and behavioral changes in our chronic vasopressin (AVP) infusion PE mouse model (C57Bl6/J). Elevated maternal AVP secretion predicts PE in humans, and chronic AVP administration is sufficient to phenocopy immune, obstetric, and renal phenotypes of PE in pregnant mice. Late-pregnancy metabolomics (N = 4-6/condition/tissue) revealed no significant disruptions in plasma, but 33 changed metabolites were changed in AVP mouse placenta, implicating altered protein, energy, and nutrient functions. Placental RNA sequencing (RNA-seq; N = 3/condition) revealed 140 differentially expressed genes (DEGs), with pathway analyses highlighting changes in structural and metabolic remodeling. Placental multi-omic integration (RNA-seq and metabolomics) identified altered purine metabolism. Analysis of RNA-seq-predicted placental secretome suggested altered immunovascular factors (e.g., C2cd4, Klk1b1). In late-gestation maternal brain, RNA-seq (N = 3/condition) revealed extensive gene suppression in the hypothalamic paraventricular nucleus (PVN, 329 DEGs; 322 down-regulated) and frontal cortex (114 DEGs; 113 down-regulated), implicating altered signaling and immune-vascular pathways, respectively. AVP increased antepartum exploratory behavior without changing depressive-like or hedonic behaviors. Spatial memory deficits in aged postpartum AVP dams were also significant and associated with molecular changes in the hippocampus. Overall, the AVP model of PE induces placental and maternal brain changes, invoking immune and vascular mechanisms. This work identifies potential mechanisms underlying PE impacts on maternal brain, with implications for associated mental health challenges.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Task-related reconfiguration patterns of frontoparietal network during motor imagery. 运动想象过程中额顶叶网络的任务相关重构模式。
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-24 DOI: 10.1016/j.neuroscience.2025.05.035
Long Chen, Lei Zhang, Zhongpeng Wang, Qi Li, Bin Gu, Dong Ming
{"title":"Task-related reconfiguration patterns of frontoparietal network during motor imagery.","authors":"Long Chen, Lei Zhang, Zhongpeng Wang, Qi Li, Bin Gu, Dong Ming","doi":"10.1016/j.neuroscience.2025.05.035","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.05.035","url":null,"abstract":"<p><p>Motor imagery (MI) is closely associated with the frontoparietal network that includes prefrontal and posterior parietal regions. Studying task-related network reconfiguration after brain shifts from the resting state to the MI task is an important way to understand the brain's response process. However, how the brain modulates functional connectivity of the frontoparietal network when it shifts to MI has not been thoroughly studied. In this study, we attempted to characterize the frontoparietal network reconfiguration patterns as the brain transitioned to motor imagery tasks. We performed the analysis using EEG signals from 52 healthy subjects during left- and right-hand MI tasks. The results indicated distinct reconfiguration patterns in the frontoparietal network across four typical brain wave rhythms (theta (4 ∼ 7 Hz), alpha (8 ∼ 13 Hz), beta (14 ∼ 30 Hz), and gamma (31 ∼ 45 Hz)). Meanwhile, there was a significant positive correlation between the frontoparietal network reconfiguration and the event-related desynchronization of alpha and beta rhythms in the sensorimotor cortex. We further found that subjects with better MI-BCI performance exhibited greater reconfiguration of the frontoparietal network in alpha and beta rhythms. These findings implied that MI was accompanied by a shift in information interaction between brain regions, which might contribute to understanding the neural mechanisms of MI.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Capturing dynamic neuronal responses to dominant and subordinate social hierarchy members with catFISH. 用catFISH捕捉对支配和从属社会等级成员的动态神经元反应。
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-23 DOI: 10.1016/j.neuroscience.2025.05.025
Madeleine F Dwortz, James P Curley
{"title":"Capturing dynamic neuronal responses to dominant and subordinate social hierarchy members with catFISH.","authors":"Madeleine F Dwortz, James P Curley","doi":"10.1016/j.neuroscience.2025.05.025","DOIUrl":"10.1016/j.neuroscience.2025.05.025","url":null,"abstract":"<p><p>Dominance hierarchies are key to social organization in group-living species, requiring individuals to recognize their own and others' ranks. This is particularly complex for mid-ranking animals, who navigate interactions with higher- and lower-ranking individuals. Using in situ hybridization, we examined how mid-ranked mice's brains respond to dominant and subordinate stimuli by labeling activity-induced immediate early genes and neuronal markers. We show that distinct neuronal populations in the amygdala and hippocampus respond differentially across social contexts. In the basolateral amygdala and dorsal endopiriform, glutamatergic Slc17a7<sup>+</sup> neurons, particularly dopamine-receptive Slc17a7<sup>+</sup>Drd1<sup>+</sup> neurons, show elevated IEG expression in response to social stimuli, with a higher response to dominant over subordinate animals. Similar response patterns are observed among GABAergic Slc32a1<sup>+</sup>Oxtr<sup>+</sup> neurons in the medial amygdala. We also identified distinct neural ensembles selectively active in response to dominant and subordinate animals by examining cell reactivation over repeated stimulus presentations. We find a higher degree of reactivation among Slc17a7<sup>+</sup>Oxtr<sup>+</sup> ensembles in the endopiriform when the same individual was presented twice in succession. A similar pattern was observed among Oxtr<sup>+</sup> neurons in the dentate gyrus hilus, while the inverse was observed among Slc17a7<sup>+</sup>Avrp1b<sup>+</sup>Oxtr<sup>+</sup> neurons in distal CA2CA3, suggesting distinct encoding or recollection mechanisms across hippocampal subregions. We also highlight methodological advances showing that IEG responses are shaped by stimulus duration and the identity of the IEG and timepoint at which expression is measured. This work lays the foundation for further precise, cell type-resolved investigation into how the brain processes social information.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impairment of emotional processing from cumulative repetitive subconcussion: Evidence from event-related potentials and sLORETA in parachuters 累积重复次脑震荡对情绪处理的损害:来自跳伞者事件相关电位和sLORETA的证据
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-22 DOI: 10.1016/j.neuroscience.2025.05.033
Haoran Zhang , Zhenghao Fu , Chenglong Cao , Shuochen Wang , Huanhuan Li , Hang Xie , Yang Zhou , Xiang Li , Jian Song
{"title":"Impairment of emotional processing from cumulative repetitive subconcussion: Evidence from event-related potentials and sLORETA in parachuters","authors":"Haoran Zhang ,&nbsp;Zhenghao Fu ,&nbsp;Chenglong Cao ,&nbsp;Shuochen Wang ,&nbsp;Huanhuan Li ,&nbsp;Hang Xie ,&nbsp;Yang Zhou ,&nbsp;Xiang Li ,&nbsp;Jian Song","doi":"10.1016/j.neuroscience.2025.05.033","DOIUrl":"10.1016/j.neuroscience.2025.05.033","url":null,"abstract":"<div><div>Repetitive subconcussion, often overlooked due to subtle symptoms, but it can lead to cumulative neural alteration. Repetitive subconcussion, commonly arising from indirect brain trauma during sports or military activities, may affect emotional processing and cognition, yet their long-term effects are unclear. This study uses event-related potentials (ERP) and standardized low-resolution brain electromagnetic tomography (sLORETA) to assess the impact of repetitive subconcussive exposure on emotional processing in parachuters. Seventy-five parachuters, divided into low, medium, and high exposure groups based on training duration, and 25 healthy controls were recruited. Participants completed the Mini-Mental State Examination (MMSE) and Beck Depression Inventory-II (BDI-II) and viewed emotional images during EEG recording to measure late positive potential (LPP) amplitudes. sLORETA identified activation patterns in emotional processing regions. Correlation between the number of jumps and LPP amplitude and scale scores were analysed.Results: Compared to healthy controls, medium and high exposure groups exhibited reduced LPP amplitudes, indicating impaired emotional processing. sLORETA analysis revealed no differences in the low exposure group, reduced activation in BA6 for the medium group, and diminished activation in BA2, BA40, and BA46 for the high group. Jump frequency correlated negatively with LPP amplitudes and positively with BDI-II scores. The results demonstrate emotional processing impairment from repetitive subconcussion, with corresponding reductions in BA6, BA2, BA40, and BA46 activation. LPP amplitudes and activation in specific brain regions may serve as biomarkers for brain health assessment in exposed populations. This study highlights the risks of repetitive subconcussion, offering a foundation for targeted interventions.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"579 ","pages":"Pages 1-9"},"PeriodicalIF":2.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased GABAA receptor open probability: Adaptive mechanisms to cope with anoxia in the painted turtle GABAA受体开放概率增加:彩龟应对缺氧的适应性机制
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-22 DOI: 10.1016/j.neuroscience.2025.05.032
Haushe Suganthan , Han Le , Ahmed Elbassiouny , Anthony Rajkumar , Vineeth A. Raveendran , Jessica C. Pressey , Melanie A. Woodin , Belinda S.W. Chang , Leslie T. Buck
{"title":"Increased GABAA receptor open probability: Adaptive mechanisms to cope with anoxia in the painted turtle","authors":"Haushe Suganthan ,&nbsp;Han Le ,&nbsp;Ahmed Elbassiouny ,&nbsp;Anthony Rajkumar ,&nbsp;Vineeth A. Raveendran ,&nbsp;Jessica C. Pressey ,&nbsp;Melanie A. Woodin ,&nbsp;Belinda S.W. Chang ,&nbsp;Leslie T. Buck","doi":"10.1016/j.neuroscience.2025.05.032","DOIUrl":"10.1016/j.neuroscience.2025.05.032","url":null,"abstract":"<div><div>The western painted turtle is the most anoxia-tolerant tetrapod known, surviving ∼ 4 months at 3 °C without oxygen. In the mammalian brain, absence of oxygen leads to hyper-excitability and cell death within minutes. A major mechanism by which painted turtles survive anoxia is a large increase of γ-aminobutyric acid (GABA) in the brain leading to a dominating Cl<sup>-</sup> conductance that clamps membrane potential near the reversal potential of the GABA<sub>A</sub> receptor. Whole-cell GABA<sub>A</sub> receptor currents are known to increase with the onset of anoxia because of increased presynaptic GABA release, we hypothesized that GABA<sub>A</sub> receptor currents may also exhibit a large increase due to increased channel open time. To investigate this, we used cell-attached single-channel patch-clamp electrophysiological techniques to measure GABA<sub>A</sub> receptor open times (P<sub>open</sub>) during a normoxic to anoxic transition in pyramidal neurons in turtle brain cortical sheets. GABA<sub>A</sub> receptor P<sub>open</sub> significantly increased 13-fold with the onset of anoxia and was blocked by the inclusion of the protein kinase C (PKC) activator PMA phorbol-12-myristate-13-acetate. Indicating the receptor was regulated by covalent modification. To investigate the molecular evolutionary mechanisms underlying these adaptations, we used codon-based likelihood models to detect changes in selective pressure amongst the GABA<sub>A</sub> receptor subunit genes. We found positive selection in <em>GABRB2</em> and <em>GABRB3</em> at sites near their ligand binding interface, likely impacting channel kinetics associated with hypoxia-tolerance. The elucidation of the adaptations associated with increased hypoxia tolerance furthers our understanding of physiological adaptations to extreme low-oxygen environments.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"579 ","pages":"Pages 10-23"},"PeriodicalIF":2.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resting-state fMRI study on male patients with Parkinson’s disease and with sexual dysfunction 男性帕金森病患者伴性功能障碍的静息态fMRI研究。
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-20 DOI: 10.1016/j.neuroscience.2025.05.030
Kunpeng Qin , Yumei Liu , Li Xue , Han Li , Yande Ren , Yaqing Li , Zihan Wang , Anmu Xie , Binghui Hou
{"title":"Resting-state fMRI study on male patients with Parkinson’s disease and with sexual dysfunction","authors":"Kunpeng Qin ,&nbsp;Yumei Liu ,&nbsp;Li Xue ,&nbsp;Han Li ,&nbsp;Yande Ren ,&nbsp;Yaqing Li ,&nbsp;Zihan Wang ,&nbsp;Anmu Xie ,&nbsp;Binghui Hou","doi":"10.1016/j.neuroscience.2025.05.030","DOIUrl":"10.1016/j.neuroscience.2025.05.030","url":null,"abstract":"<div><div>Sexual dysfunction (SD) is a common non-motor symptom in Parkinson’s disease (PD) that substantially reduces patients’ quality of life. However, the underlying neural mechanisms of SD in PD remain poorly understood. This study aimed to investigate the role of functional abnormalities in brain regions with dopaminergic innervation in male PD patients with SD, using resting-state functional magnetic resonance imaging (rs-fMRI). A total of 34 male PD patients were enrolled. The bilateral caudate, putamen, nucleus accumbens, and hypothalamus were selected as regions of interest (ROIs), and seed-based functional connectivity (FC) analysis was performed to compare differences in brain connectivity between PD patients with sexual dysfunction (PD-SD) and those without sexual dysfunction (PD-nSD). Compared to PD-nSD patients, those with SD exhibited significantly reduced FC between the left putamen and the right inferior parietal lobule, between the right lateral hypothalamus (LH) and the right middle frontal gyrus, and between the right medial hypothalamus (MH) and the right postcentral gyrus. These altered FC patterns effectively distinguished PD-SD from PD-nSD patients. Moreover, FC abnormalities involving the LH were significantly correlated with SD severity, as measured by the International Index of Erectile Function (IIEF), in PD-SD patients. In summary, our findings suggest that dysfunction in dopaminergically innervated brain regions may contribute to the pathophysiology of SD in male PD patients. These results offer novel insights into the neural substrates of SD in PD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 315-321"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying molecular pathways of olfactory dysfunction in Parkinson’s disease through a systems biology framework 通过系统生物学框架识别帕金森病嗅觉功能障碍的分子途径。
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-20 DOI: 10.1016/j.neuroscience.2025.05.031
Nicolas Daniel Glasbauer , Silvia Sookoian , Carlos José Pirola
{"title":"Identifying molecular pathways of olfactory dysfunction in Parkinson’s disease through a systems biology framework","authors":"Nicolas Daniel Glasbauer ,&nbsp;Silvia Sookoian ,&nbsp;Carlos José Pirola","doi":"10.1016/j.neuroscience.2025.05.031","DOIUrl":"10.1016/j.neuroscience.2025.05.031","url":null,"abstract":"<div><div>The sense of smell is essential for human perception. Olfactory function declines with increasing age, affecting a substantial portion of the elderly population, and this decline is more pronounced in men. This reduction can be attributed to anatomical and degenerative changes in the brain and olfactory receptors. There is robust clinical evidence indicating an association between olfactory perception decline/deficit (OPD) and major neurodegenerative diseases, with severe deficits observed in Alzheimer’s and Parkinson’s disease and milder effects noted in other conditions. However, its molecular bases have not yet been identified.</div><div>Here, we explored the molecular connection between OPD and Parkinson’s disease by conducting data-mining, gene enrichment analysis, and examining protein-interaction networks using systems biology approaches.</div><div>We found pathways associated with both OPD and Parkinson’s disease, identifying over 300 relevant genes. These genes belong to biologically relevant gene families, including transporters, kinases, nuclear receptors, transcription factors, and olfactory and other G protein-coupled receptors. Functional enrichment analysis revealed shared biological processes between OPD and Parkinson’s disease, such as synaptic signalling and neuroinflammation. Mitochondrial gene enrichment was unique to Parkinson’s. Both conditions exhibited a scarcity of associated genes on the Y chromosome but an even distribution on the non-pseudoautosomal region of the X chromosome, potentially explaining sex prevalence differences.</div><div>In conclusion, our study suggests olfactory testing may help diagnose cognitive decline in neurodegenerative diseases. Further research is needed to understand the connection between OPD, aging, and other diseases and to examine olfactory performance in screening individuals at risk of Parkinson’s disease and similar conditions.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 264-271"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Miro1: A potential target for treating neurological disorders Miro1:治疗神经系统疾病的潜在靶点
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-20 DOI: 10.1016/j.neuroscience.2025.05.019
Linghua Zeng , Juan Yang , Conghui Zhang , Junjie Zhu , Saichun Zhong , Xing Liu , Haiyu Xie , Lifeng Wang , Li Chen , Maolin Zhong , Fuzhou Hua , Weidong Liang
{"title":"Miro1: A potential target for treating neurological disorders","authors":"Linghua Zeng ,&nbsp;Juan Yang ,&nbsp;Conghui Zhang ,&nbsp;Junjie Zhu ,&nbsp;Saichun Zhong ,&nbsp;Xing Liu ,&nbsp;Haiyu Xie ,&nbsp;Lifeng Wang ,&nbsp;Li Chen ,&nbsp;Maolin Zhong ,&nbsp;Fuzhou Hua ,&nbsp;Weidong Liang","doi":"10.1016/j.neuroscience.2025.05.019","DOIUrl":"10.1016/j.neuroscience.2025.05.019","url":null,"abstract":"<div><div>The Miro1 protein is a member of the mitochondrial Rho GTPase (Miro) protein family and plays a crucial role in regulating the dynamic processes of mitochondria and participating in cellular movement and mitochondrial transport. In the nervous system, it ensures adequate energy supply for normal neuronal function and synaptic transmission. Additionally, Miro1 actively participates in the regulation of mitochondrial quality control and stress responses within neurons. Its primary function is to sense intracellular stress signals to regulate mitochondrial movement and metabolism, thereby adapting to environmental changes. Multiple studies have indicated that the Miro1 protein is associated with the pathogenesis of various neurological disorders, such as Alzheimer’s Disease(AD), Parkinson’s Disease(PD), and Amyotrophic Lateral Sclerosis(ALS). This article reviews the mechanistic role of Miro1 in these diseases and summarizes the latest research on its involvement in neurological disorders. These efforts aim to provide unified treatment strategies for certain neurological disorders and explore the potential for treating complex neurological diseases.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 228-239"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences in neurophysiological resting-state alpha spectral events in 4–12-year-old children with prenatal exposure to alcohol relative to typically developing controls 产前接触酒精的4-12岁儿童与正常发育对照组的神经生理静息状态α谱事件差异
IF 2.9 3区 医学
Neuroscience Pub Date : 2025-05-19 DOI: 10.1016/j.neuroscience.2025.05.028
D. Roberts , F.T. Candelaria-Cook , D. Mun , O. Myers , M. Schendel , M. Alsameen , P. Sanjuan , C. Cerros , D. Hill , J. Stephen
{"title":"Differences in neurophysiological resting-state alpha spectral events in 4–12-year-old children with prenatal exposure to alcohol relative to typically developing controls","authors":"D. Roberts ,&nbsp;F.T. Candelaria-Cook ,&nbsp;D. Mun ,&nbsp;O. Myers ,&nbsp;M. Schendel ,&nbsp;M. Alsameen ,&nbsp;P. Sanjuan ,&nbsp;C. Cerros ,&nbsp;D. Hill ,&nbsp;J. Stephen","doi":"10.1016/j.neuroscience.2025.05.028","DOIUrl":"10.1016/j.neuroscience.2025.05.028","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of age and prenatal alcohol exposure (PAE) on the constituent parameters underlying mean alpha power.</div></div><div><h3>Methods</h3><div>Resting-state magnetoencephalography (MEG) alpha events were characterized by measuring event spectral power, number of events per epoch, duration of events, and frequency span within the alpha band (7–13 Hz) in 82 typically developing controls (TDCs) and 53 participants with PAE/FASD. We examined the relationship between these parameters and overall mean alpha power as well as how they differ with age and PAE/FASD.</div></div><div><h3>Results</h3><div>Age negatively correlated with mean event duration in both groups, (<em>r</em> = -0.29, <em>p</em> &lt; 0.001) with duration reduced in older participants. Age negatively correlated with mean alpha power’s association with mean event duration in PAE/FASD (<em>r</em> = -0.38, <em>p</em> &lt; 0.05) and positively correlated with mean alpha power’s association with mean event frequency span in both groups (r = 0.22, p &lt; 0.05). The correlation between mean alpha power and mean event duration (p = 0.038) was stronger in TDCs. Despite the group difference, longer event durations led to more mean alpha power in both groups. Mean alpha power negatively correlated with mean event frequency span in both groups but the negative correlation was stronger in the TDC group (p = 0.036)</div></div><div><h3>Conclusion</h3><div>The differences found in alpha events with age and PAE may provide valuable insights into the physiological correlates of attention and highlight the potential of alpha oscillations as biomarkers for understanding attention-related deficits in children with prenatal alcohol exposure.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 332-342"},"PeriodicalIF":2.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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