Neuroscience最新文献

microRNAs as molecular tools for brain health: Neuroprotective potential in neurodegenerative disorders

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-08 DOI: 10.1016/j.neuroscience.2025.04.012

Mozhgan Abasi , Anvarsadat Kianmehr , Athena Variji , Parisa Sangali , Abdolkarim Mahrooz

{"title":"microRNAs as molecular tools for brain health: Neuroprotective potential in neurodegenerative disorders","authors":"Mozhgan Abasi , Anvarsadat Kianmehr , Athena Variji , Parisa Sangali , Abdolkarim Mahrooz","doi":"10.1016/j.neuroscience.2025.04.012","DOIUrl":"10.1016/j.neuroscience.2025.04.012","url":null,"abstract":"<div><div>As research on microRNAs (miRNAs) advances, it is becoming increasingly clear that these small molecules play crucial roles in the central nervous system (CNS). They are involved in various essential neuronal functions, with specific miRNAs preferentially expressed in different cell types within the nervous system. Notably, certain miRNAs are found at higher levels in the brain and spinal cord compared to other tissues, suggesting they may have specialized functions in the CNS. miRNAs associated with long-term neurodegenerative changes could serve as valuable tools for early treatment decisions and disease monitoring. The significance of miRNAs such as miR-320, miR-146 and miR-29 in the early diagnosis of neurodegenerative disorders becomes evident, especially considering that many neurological and physical symptoms manifest only after substantial degeneration of specific neurons. Interestingly, serum miRNA levels such as miR-92 and miR-486 may correlate with various MRI parameters in multiple sclerosis. Targeting miRNAs using antisense strategies, such as antisense miR-146 and miR-485, may provide advantages over targeting mRNAs, as a single anti-miRNA can regulate multiple disease-related genes. In the future, anti-miRNA-based therapeutic approaches could be integrated into the clinical management of neurological diseases. Certain miRNAs, including miR-223, miR-106, miR-181, and miR-146, contribute to the pathogenesis of various neurodegenerative diseases and thus warrant greater attention. This knowledge could pave the way for the identification of new diagnostic, prognostic, and theranostic biomarkers, and potentially guiding the development of RNA-based therapeutic strategies. This review highlights recent research on the roles of miRNAs in the nervous system, particularly their protective functions in neurodegenerative disorders.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"574 ","pages":"Pages 83-103"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subthalamic nucleus dynamics during executive functioning: Insights from local field potentials in Parkinson’s disease

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-08 DOI: 10.1016/j.neuroscience.2025.04.006

Lejla Paracka , Marcus Heldmann , Florian Lange , Assel Saryyeva , Martin Klietz , Thomas F. Münte , Bruno Kopp , Florian Wegner , Joachim K. Krauss

{"title":"Subthalamic nucleus dynamics during executive functioning: Insights from local field potentials in Parkinson’s disease","authors":"Lejla Paracka , Marcus Heldmann , Florian Lange , Assel Saryyeva , Martin Klietz , Thomas F. Münte , Bruno Kopp , Florian Wegner , Joachim K. Krauss","doi":"10.1016/j.neuroscience.2025.04.006","DOIUrl":"10.1016/j.neuroscience.2025.04.006","url":null,"abstract":"<div><div>This study explores the involvement of the subthalamic nucleus (STN) in executive functions, particularly cognitive flexibility, in Parkinson’s disease (PD) patients. Utilizing a computerized Wisconsin Card Sorting Task (WCST) and local field potential (LFP) recordings from implanted deep brain stimulation (DBS) electrodes, we investigated task-specific neural dynamics. Behavioural results demonstrated increased error rates and prolonged response times in trials requiring set-shifting and rule induction via cross-temporal information integration. Electrophysiological analyses revealed integration-specific LFP modulations, including enhanced theta-band activity linked to conflict monitoring and cognitive control during high-demand trials, and beta-band suppression associated with motor inhibition and task disengagement. These findings underscore the STN’s integrative role in non-motor domains, supporting its function in cross-temporal information integration for cognitive control. The results also highlight the utility of the WCST for assessing multiple executive processes and the potential of LFP-based biomarkers to refine DBS programming. Despite the relatively small sample size, this study provides novel insights into the oscillatory dynamics of the STN, emphasizing its broader role in decision-making and executive control. Future research should expand the understanding of the STN’s contributions across cognitive domains.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"574 ","pages":"Pages 65-73"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fully automatic radiomics pipeline for postoperative facial nerve function prediction of vestibular schwannoma

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-08 DOI: 10.1016/j.neuroscience.2025.04.008

Gang Song , Keyuan Li , Zhuozheng Wang , Wei Liu , Qi Xue , Jiantao Liang , Yiqiang Zhou , Haoming Geng , Dong Liu

{"title":"A fully automatic radiomics pipeline for postoperative facial nerve function prediction of vestibular schwannoma","authors":"Gang Song , Keyuan Li , Zhuozheng Wang , Wei Liu , Qi Xue , Jiantao Liang , Yiqiang Zhou , Haoming Geng , Dong Liu","doi":"10.1016/j.neuroscience.2025.04.008","DOIUrl":"10.1016/j.neuroscience.2025.04.008","url":null,"abstract":"<div><div>Vestibular schwannoma (VS) is the most prevalent intracranial schwannoma. Surgery is one of the options for the treatment of VS, with the preservation of facial nerve (FN) function being the primary objective. Therefore, postoperative FN function prediction is essential. However, achieving automation for such a method remains a challenge. In this study, we proposed a fully automatic deep learning approach based on multi-sequence magnetic resonance imaging (MRI) to predict FN function after surgery in VS patients. We first developed a segmentation network 2.5D Trans-UNet, which combined Transformer and U-Net to optimize contour segmentation for radiomic feature extraction. Next, we built a deep learning network based on the integration of 1DConvolutional Neural Network (1DCNN) and Gated Recurrent Unit (GRU) to predict postoperative FN function using the extracted features. We trained and tested the 2.5D Trans-UNet segmentation network on public and private datasets, achieving accuracies of 89.51% and 90.66%, respectively, confirming the model’s strong performance. Then Feature extraction and selection were performed on the private dataset’s segmentation results using 2.5D Trans-UNet. The selected features were used to train the 1DCNN-GRU network for classification. The results showed that our proposed fully automatic radiomics pipeline outperformed the traditional radiomics pipeline on the test set, achieving an accuracy of 88.64%, demonstrating its effectiveness in predicting the postoperative FN function in VS patients. Our proposed automatic method has the potential to become a valuable decision-making tool in neurosurgery, assisting neurosurgeons in making more informed decisions regarding surgical interventions and improving the treatment of VS patients.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"574 ","pages":"Pages 124-137"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p53 inhibition during audiogenic kindling in Krushinsky-Molodkina rats attenuates seizure severity and prevents neurodegeneration in the hippocampus

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-08 DOI: 10.1016/j.neuroscience.2025.04.013

Alexey A. Kulikov , Alexandra A. Naumova , Yulia O. Sokolova, Andrey A. Suponin, Konstantin A. Krasnov, Svetlana D. Nikolaeva, Elena V. Chernigovskaya, Elena D. Bazhanova, Margarita V. Glazova

{"title":"p53 inhibition during audiogenic kindling in Krushinsky-Molodkina rats attenuates seizure severity and prevents neurodegeneration in the hippocampus","authors":"Alexey A. Kulikov , Alexandra A. Naumova , Yulia O. Sokolova, Andrey A. Suponin, Konstantin A. Krasnov, Svetlana D. Nikolaeva, Elena V. Chernigovskaya, Elena D. Bazhanova, Margarita V. Glazova","doi":"10.1016/j.neuroscience.2025.04.013","DOIUrl":"10.1016/j.neuroscience.2025.04.013","url":null,"abstract":"<div><div>In the present study, we analyzed the effects of the p53 inhibitor pifithrin-α (PFT) on the expression of brainstem audiogenic seizures (AGS) and limbic seizures in Krushinsky-Molodkina (KM) rats genetically prone to AGS. To reproduce limbic/mesial temporal lobe epilepsy (TLE)-like condition in KM rats, we used repetitive AGS stimulations (audiogenic kindling) during 14 days. In parallel with AGS stimulations, KM rats received daily intraperitoneal injections of PFT. Our data demonstrated that PFT treatment significantly decreased the duration and severity of both brainstem AGS and limbic seizures. In addition, PFT partially prevented the kindling-induced neurodegeneration and activation of apoptotic mechanisms in the hippocampus of KM rats. Moreover, PFT treatment led to the persistent upregulation of anti-apoptotic Bcl-2, along with GluA2 and GluN2A, glutamate receptor subunits which are involved into the mechanisms supporting cell survival and preventing neuronal hyperexcitability. Altogether, our data confirm that p53 can be considered as a perspective target for the development of novel strategies to mitigate seizure activity and avert its deleterious consequences.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"574 ","pages":"Pages 138-151"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning for cerebral vascular occlusion segmentation: A novel ConvNeXtV2 and GRN-integrated U-Net framework for diffusion-weighted imaging

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-07 DOI: 10.1016/j.neuroscience.2025.04.010

Suat Ince , Ismail Kunduracioglu , Ali Algarni , Bilal Bayram , Ishak Pacal

{"title":"Deep learning for cerebral vascular occlusion segmentation: A novel ConvNeXtV2 and GRN-integrated U-Net framework for diffusion-weighted imaging","authors":"Suat Ince , Ismail Kunduracioglu , Ali Algarni , Bilal Bayram , Ishak Pacal","doi":"10.1016/j.neuroscience.2025.04.010","DOIUrl":"10.1016/j.neuroscience.2025.04.010","url":null,"abstract":"<div><div>Cerebral vascular occlusion is a serious condition that can lead to stroke and permanent neurological damage due to insufficient oxygen and nutrients reaching brain tissue. Early diagnosis and accurate segmentation are critical for effective treatment planning. Due to its high soft tissue contrast, Magnetic Resonance Imaging (MRI) is commonly used for detecting these occlusions such as ischemic stroke. However, challenges such as low contrast, noise, and heterogeneous lesion structures in MRI images complicate manual segmentation and often lead to misinterpretations. As a result, deep learning-based Computer-Aided Diagnosis (CAD) systems are essential for faster and more accurate diagnosis and treatment methods, although they can sometimes face challenges such as high computational costs and difficulties in segmenting small or irregular lesions. This study proposes a novel U-Net architecture enhanced with ConvNeXtV2 blocks and GRN-based Multi-Layer Perceptrons (MLP) to address these challenges in cerebral vascular occlusion segmentation. This is the first application of ConvNeXtV2 in this domain. The proposed model significantly improves segmentation accuracy, even in low-contrast regions, while maintaining high computational efficiency, which is crucial for real-world clinical applications. To reduce false positives and improve overall accuracy, small lesions (≤5 pixels) were removed in the preprocessing step with the support of expert clinicians. Experimental results on the ISLES 2022 dataset showed superior performance with an Intersection over Union (IoU) of 0.8015 and a Dice coefficient of 0.8894. Comparative analyses indicate that the proposed model achieves higher segmentation accuracy than existing U-Net variants and other methods, offering a promising solution for clinical use.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"574 ","pages":"Pages 42-53"},"PeriodicalIF":2.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding goal-habit brain networks of OCD from the structural and functional connectivity.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-05 DOI: 10.1016/j.neuroscience.2025.04.004

Haocheng Chen, Xiao Dong Chen, Minyao Xie, Xuedi Zhang, Shasha Song, Huan Zhang, Ping Zhou, Na Liu, Ning Zhang

{"title":"Decoding goal-habit brain networks of OCD from the structural and functional connectivity.","authors":"Haocheng Chen, Xiao Dong Chen, Minyao Xie, Xuedi Zhang, Shasha Song, Huan Zhang, Ping Zhou, Na Liu, Ning Zhang","doi":"10.1016/j.neuroscience.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.04.004","url":null,"abstract":"<p><p>Obsessive-Compulsive Disorder (OCD) may involve an imbalance between goal-directed and habitual learning systems, and this study investigates the structural and functional brain networks underpinning these systems in OCD. Using predefined brain regions, structural and functional connectivity networks were constructed, and methods such as network-based statistics, average connectivity strength, structural-functional coupling, and partial least squares path modeling were employed to compare OCD patients and healthy controls. The results revealed that OCD patients showed increased structural connectivity within both the goal-directed and habitual learning networks, particularly in the subnetwork that connects these systems. However, functional connectivity strength was reduced in both the habitual learning network and the subnetwork connecting goal-directed and habitual learning systems. The symptoms of ordering and hoarding are, to some extent, correlated with the structural-functional coupling network and network characteristics. These findings suggest that alterations in both structural and functional brain networks underpin goal-directed and habitual learning in OCD, with increased structural connectivity potentially reflecting compensatory mechanisms, while reduced functional connectivity may contribute to the symptoms of OCD. Further research is required to better understand the complex interplay between these learning systems in OCD, considering symptom heterogeneity and disease's progression.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of dual-target repetitive transcranial magnetic stimulation in patients with minimally conscious state: A preliminary study

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-05 DOI: 10.1016/j.neuroscience.2025.03.068

Yanhua Li , Ye Zhang , Xiaoping Wan , Xiao Yan , Weiqun Song

{"title":"Effects of dual-target repetitive transcranial magnetic stimulation in patients with minimally conscious state: A preliminary study","authors":"Yanhua Li , Ye Zhang , Xiaoping Wan , Xiao Yan , Weiqun Song","doi":"10.1016/j.neuroscience.2025.03.068","DOIUrl":"10.1016/j.neuroscience.2025.03.068","url":null,"abstract":"<div><div>Repetitive transcranial magnetic stimulation (rTMS) is a promising neuromodulation therapy that facilitates recovery in patients with prolonged disorders of consciousness (pDOC). This study aimed to evaluate the efficacy of dual-target rTMS in treating patients with minimally conscious state (MCS). A total of 20 MCS patients were recruited and randomly assigned to either the real or sham stimulation group. Participants received 10 Hz rTMS targeting the left prefrontal and parietal cortices for 10 consecutive days. The Coma Recovery Scale-Revised (CRS-R) and resting-state EEG were recorded, with relative power spectral density and coherence subsequently computed. Additionally, behavioral assessments were conducted over a six-month follow-up period. Our findings indicate that 10 Hz dual-target rTMS enhances brain oscillatory activity in the frontal, central, and parietal lobes. Specifically, the treatment resulted in a reduction in delta-band activity and an increase in alpha-band activity in the frontal lobes, as well as an elevation in alpha-band power in the central and parietal region. In contrast, no significant changes were observed in the sham stimulation group. Meanwhile, in the real stimulation group, long-distance coherence (F3-P4) exhibited increased in alpha-band. These findings suggest that enhanced oscillatory activity and EEG functional connectivity may underlie the modulatory effects of dual-target rTMS. Additionally, a combined prefrontal and parietal cortex approach is another viable option in rTMS protocols for patients with pDOC.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"573 ","pages":"Pages 460-467"},"PeriodicalIF":2.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agonists for glutamate, acetylcholine, and orexin cause non-photic phase shifts when applied to the intergeniculate leaflet

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-05 DOI: 10.1016/j.neuroscience.2025.04.007

Mahtab Moshirpour , Katelyn G. Horsley , Susana Puche Saud , Chantelle McCance , Maeve Scotland , Michael C. Antle

{"title":"Agonists for glutamate, acetylcholine, and orexin cause non-photic phase shifts when applied to the intergeniculate leaflet","authors":"Mahtab Moshirpour , Katelyn G. Horsley , Susana Puche Saud , Chantelle McCance , Maeve Scotland , Michael C. Antle","doi":"10.1016/j.neuroscience.2025.04.007","DOIUrl":"10.1016/j.neuroscience.2025.04.007","url":null,"abstract":"<div><div>The intergeniculate leaflet (IGL) and its neurotransmitter, Neuropeptide Y, are both necessary and sufficient inputs to the SCN to mediate non-photic phase shifting of circadian rhythms. In this study we examined what arousal inputs might participate in activation of the IGL during a non-photic manipulation. The ACh agonist carbachol caused non-photic phase shifts when applied to the IGL at CT6, but blocking ACh muscarinic receptors in the IGL with atropine did not attenuate phase shifts to a 3 h sleep deprivation (SD) procedure during the midday. Orexin, an important arousal neuropeptide, densely innervates the IGL. Pretreatment with the dual OX1/OX2 receptor antagonist MK-6096 did not attenuate phase shifts to 3 h midday SD. When injected into the IGL alone, orexin produced small and inconsistent phase shifts that overall did not differ significantly from vehicle control. The glutamate agonist NMDA caused non-photic-like phase shifts when applied to the IGL. While a cocktail of both carbachol and NMDA inhibited each other’s phase shifting effects, a cocktail that included orexin, carbachol and NMDA reversed this inhibition and yielded the largest phase shifts of all. This suggests that the IGL is likely activated by numerous convergent arousal inputs during a phase-shifting non-photic manipulation.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"574 ","pages":"Pages 114-123"},"PeriodicalIF":2.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pterostilben upregulates GAD67-mediated GABA synthesis in hippocampal parvalbumin-positive cells

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-04 DOI: 10.1016/j.neuroscience.2025.03.060

Yuki Kajita, Ko Ono, Saya Kaneda, Hajime Mushiake

{"title":"Pterostilben upregulates GAD67-mediated GABA synthesis in hippocampal parvalbumin-positive cells","authors":"Yuki Kajita, Ko Ono, Saya Kaneda, Hajime Mushiake","doi":"10.1016/j.neuroscience.2025.03.060","DOIUrl":"10.1016/j.neuroscience.2025.03.060","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Pterostilbene (PTE, 3,5-dimethoxy-4′-hydroxystilbene) is a naturally occurring polyphenol which has antiepileptic properties, and can be utilized as a prophylaxis in patients with seizures and who are at risk of developing epilepsy. However, the effects of PTE on the gamma-aminobutyric acid (GABA)-mediated (GABAergic) nervous system are poorly understood. This study aimed to evaluate the effects of PTE on the GABAergic neurons.</div></div><div><h3>Experimental approach</h3><div>Male Long-Evans rats were orally administered PTE (200 mg/kg, 5 % Tween 80 in saline) for 10 days using a plastic sonde. The control group was treated with 5 % Tween 80 in saline in a similar manner. Approximately 24 h after the last treatment, we fixed and removed the brains and examined GABA, GAD67, and GAD65 expression in the hippocampal layers using immunohistochemical analysis. In addition, changed GAD expression was compared between the two main GABAergic subtypes, PV<sup>+</sup> and SOM<sup>+</sup> cells.</div></div><div><h3>Key results</h3><div>We demonstrated that PTE treatment increased GABA expression in the hippocampus. These effects can be attributed to GAD67-mediated GABA synthesis in the PV<sup>+</sup> cells.</div></div><div><h3>Conclusions and implications</h3><div>Our results uncovered that PTE increased GABA synthesis, suggesting that PTE has potential as a prophylactic drug for patients at risk of developing epilepsy.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"573 ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the nexus: Sleep disorders, circadian dysregulation, and Alzheimer’s disease 探索联系：睡眠障碍、昼夜节律失调和阿尔茨海默病。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-04-04 DOI: 10.1016/j.neuroscience.2025.03.066

Pratima Khandayataray , Meesala Krishna Murthy

{"title":"Exploring the nexus: Sleep disorders, circadian dysregulation, and Alzheimer’s disease","authors":"Pratima Khandayataray , Meesala Krishna Murthy","doi":"10.1016/j.neuroscience.2025.03.066","DOIUrl":"10.1016/j.neuroscience.2025.03.066","url":null,"abstract":"<div><div>We reviewed the connections among Alzheimer’s disease (AD), sleep deprivation, and circadian rhythm disorders. Evidence is mounting that disrupted sleep and abnormal circadian rhythms are not merely symptoms of AD, but are also involved in accelerating the disease. Amyloid-beta (Aβ) accumulates, a feature of AD, and worsens with sleep deprivation because glymphatic withdrawal is required to clear toxic proteins from the brain. In addition, disturbances in circadian rhythm can contribute to the induction of neuroinflammation and oxidative stress, thereby accelerating neurodegenerative processes. While these interactions are bidirectional, Alzheimer’s pathology further disrupts sleep and circadian function in a vicious cycle that worsens cognitive decline, which is emphasized in the review. The evidence that targeting sleep and circadian mechanisms may serve as therapeutic strategies for AD was strengthened by this study through the analysis of the molecular and physiological pathways. Further work on this nexus could help unravel the neurobiological mechanisms common to the onset of Alzheimer’s and disrupted sleep and circadian regulation, which could result in earlier intervention to slow or prevent the onset of the disease.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"574 ","pages":"Pages 21-41"},"PeriodicalIF":2.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0