Neuroscience最新文献

Multifaceted roles of DLG3/SAP102 in neurophysiology, neurological disorders and tumorigenesis.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-06 DOI: 10.1016/j.neuroscience.2024.11.081

Khalid Idris Gidado, Funmilayo O Adeshakin, Lawan Rabiu, Ziyang Zhang, Guizhong Zhang, Xiaochun Wan

{"title":"Multifaceted roles of DLG3/SAP102 in neurophysiology, neurological disorders and tumorigenesis.","authors":"Khalid Idris Gidado, Funmilayo O Adeshakin, Lawan Rabiu, Ziyang Zhang, Guizhong Zhang, Xiaochun Wan","doi":"10.1016/j.neuroscience.2024.11.081","DOIUrl":"10.1016/j.neuroscience.2024.11.081","url":null,"abstract":"DLG3, also known as Synapse-associated protein 102 (SAP102), is essential for the organization and plasticity of excitatory synapses within the central nervous system (CNS). It plays a critical role in clustering and moving key components necessary for learning and memory processes. Mutations in the DLG3 gene, which result in truncated SAP102 proteins, have been associated with a range of neurological disorders, including X-linked intellectual disability (XLID), autism spectrum disorders (ASD), and schizophrenia, all of which can disrupt synaptic structure and cognitive functions. Abnormal SAP102 expression has also been linked to various psychiatric and neurodegenerative conditions, such as bipolar disorder, major depression, and Alzheimer's disease. Recent studies suggest that SAP102 influences cancer development and metastasis by regulating multiple signaling pathways, including the PI3K/AKT axis and the Hippo pathway. Moreover, SAP102 has been demonstrated to regulate tumor-induced bone pain through activating NMDA receptors. These findings highlight SAP102 as a promising therapeutic target for both neurological disorders and cancer. Therefore, further investigation into the regulatory roles of SAP102 in neural development and disease may lead to novel therapeutic approaches for treating synaptic disorders and managing cancer progression.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"192-201"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinopathy in Parkinson's disease: A potential biomarker for early diagnosis and clinical assessment.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-30 DOI: 10.1016/j.neuroscience.2024.11.073

Kaimin Xiao, Jianglong Li, Luyu Zhou, Xianghong Liu, Zufeng Xiao, Rongxin He, Heling Chu, Yuping Tang, Ping Liu, Xuejing Lu

{"title":"Retinopathy in Parkinson's disease: A potential biomarker for early diagnosis and clinical assessment.","authors":"Kaimin Xiao, Jianglong Li, Luyu Zhou, Xianghong Liu, Zufeng Xiao, Rongxin He, Heling Chu, Yuping Tang, Ping Liu, Xuejing Lu","doi":"10.1016/j.neuroscience.2024.11.073","DOIUrl":"10.1016/j.neuroscience.2024.11.073","url":null,"abstract":"Parkinson's disease (PD) is a prevalent neurodegenerative disorder caused by degeneration of dopaminergic neurons, originating from the substantia nigra pars compacta, and characterized by motor symptoms such as bradykinesia, muscle rigidity, resting tremor, and postural instability, as well as non-motor symptoms such as anxiety, depression, reduced sense of smell, cognitive impairment, and visual dysfunction. Emerging evidence highlights the retina as a promising site for non-invasive exploration of PD pathology, due to its shared embryonic origin with the central nervous system. In recent years, with the development of ophthalmic technology, the acquisition of retinal-related function and structure has gradually become mature. PD-related retinal changes have become a research hotspot for non-motor symptoms of PD. This review provides a comprehensive synthesis of retinal dysfunctions in PD, focusing on structural and functional changes as potential biomarkers for early diagnosis and clinical assessment. By integrating findings from advanced imaging and electrophysiological studies, this review introduces novel perspectives on the correlation between retinal changes and PD pathophysiology, offering innovative approaches for early detection, disease progression monitoring, and therapeutic stratification.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"202-210"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HLA is a potent immunoinflammatory target in asymptomatic Alzheimer's disease. 在无症状阿尔茨海默病中，HLA 是一个强有力的免疫炎症靶点。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-19 DOI: 10.1016/j.neuroscience.2024.11.049

Yingwei Zheng, Xiaobo Yu, Wenwen Li, Fan Wu, Yunlu Gu, Keyao Liu, Sijue Tao, Yue Liu, Qian Wang

{"title":"HLA is a potent immunoinflammatory target in asymptomatic Alzheimer's disease.","authors":"Yingwei Zheng, Xiaobo Yu, Wenwen Li, Fan Wu, Yunlu Gu, Keyao Liu, Sijue Tao, Yue Liu, Qian Wang","doi":"10.1016/j.neuroscience.2024.11.049","DOIUrl":"10.1016/j.neuroscience.2024.11.049","url":null,"abstract":"Alzheimer's disease (AD) is a common neurodegenerative disease, neuroinflammation is an early pathological feature of AD. However, the alteration of the immune microenvironment in asymptomatic AD was not fully explained. In this study, we aimed to utilize the transcriptome data of AD patients in public databases to reveal the change of immune microenvironment in asymptomatic AD and screen the potential drug targets. A series of bioinformatics analyses were done, including differentially expressed genes (DEGs) screening, enrichment analysis, PPI network construction, and hub gene identification. Meanwhile, the selected hub genes were validated in APP/PS-1(AD) mice. Importantly, seven enrichment pathways and eight hub genes associated with inflammation were identified in asymptomatic AD. Correspondingly, more hub genes were increased in the hippocampus in AD mice compared to the other four brain regions. Accompanied by the activation of microglia and astrocytes, the inflammatory cytokines were increased in the hippocampus of AD mice. Subsequently, the relationship between HLA-C and inflammation was evaluated in AD mice. HLA-C was correlated with the activation of microglia, and HLA-DRB1 with IL-6 in the hippocampus. Moreover, HLA-C is expressed in the microglia cells and astrocytes. Further, five FDA-approved drugs (Itrazole, Dfo, Syrosingopine, Cefoperazone, and Pradaxa) were predicted as the common drug targeting HLA-C and HLA-DRB1 by molecular docking. Taken together, the results revealed the changes in the immune microenvironment of asymptomatic AD and provided a new perspective for the development of anti-inflammatory drugs for AD early treatment.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"386-398"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning-based segmentation of acute ischemic stroke MRI lesions and recurrence prediction within 1 year after discharge: A multicenter study.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-02 DOI: 10.1016/j.neuroscience.2024.12.002

Jianmo Liu, Jingyi Li, Yifan Wu, Haowen Luo, Pengfei Yu, Rui Cheng, Xiaoman Wang, Hongfei Xian, Bin Wu, Yongsen Chen, Jingyao Ke, Yingping Yi

{"title":"Deep learning-based segmentation of acute ischemic stroke MRI lesions and recurrence prediction within 1 year after discharge: A multicenter study.","authors":"Jianmo Liu, Jingyi Li, Yifan Wu, Haowen Luo, Pengfei Yu, Rui Cheng, Xiaoman Wang, Hongfei Xian, Bin Wu, Yongsen Chen, Jingyao Ke, Yingping Yi","doi":"10.1016/j.neuroscience.2024.12.002","DOIUrl":"10.1016/j.neuroscience.2024.12.002","url":null,"abstract":"Objective: To explore the performance of deep learning-based segmentation of infarcted lesions in the brain magnetic resonance imaging (MRI) of patients with acute ischemic stroke (AIS) and the recurrence prediction value of radiomics within 1 year after discharge as well as to develop a model incorporating radiomics features and clinical factors to accurately predict AIS recurrence.Materials and methods: To generate a segmentation model of MRI lesions in AIS, the deep learning algorithm multiscale residual attention UNet (MRA-UNet) was employed. Furthermore, the risk factors for AIS recurrence within 1 year were explored using logistic regression (LR) analysis. In addition, to develop the prediction model for AIS recurrence within 1 year after discharge, four machine learning algorithms, namely, LR, RandomForest (RF), CatBoost, and XGBoost, were employed based on radiomics data, clinical data, and their combined data.Results: In the validation set, the Mean Dice (MDice) and Mean IOU (MIou) of the MRA-UNet segmentation model were 0.816 and 0.801, respectively. In multivariate LR analysis, age, renal insufficiency, C-reactive protein, triglyceride glucose index, prognostic nutritional index, and infarct volume were identified as the independent risk factors for AIS recurrence. Furthermore, in the validation set, combining radiomics data and clinical data, the AUC was 0.835 (95%CI:0.738, 0.932), 0.834 (95%CI:0.740, 0.928), 0.858 (95%CI:0.770, 0.946), and 0.842 (95%CI:0.752, 0.932) for the LR, RF, CatBoost, and XGBoost models, respectively.Conclusion: The MRA-UNet model can effectively improve the segmentation accuracy of MRI. The model, which was established by combining radiomics features and clinical factors, held some value for predicting AIS recurrence within 1 year.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"222-231"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ergothioneine-rich Lentinula edodes mushroom extract restores mitochondrial functions in senescent HT22 cells.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-04 DOI: 10.1016/j.neuroscience.2024.11.082

Yasaaswini Apparoo, Chia Wei Phan, Umah Rani Kuppusamy, Eric Chan Wei Chiang

{"title":"Ergothioneine-rich Lentinula edodes mushroom extract restores mitochondrial functions in senescent HT22 cells.","authors":"Yasaaswini Apparoo, Chia Wei Phan, Umah Rani Kuppusamy, Eric Chan Wei Chiang","doi":"10.1016/j.neuroscience.2024.11.082","DOIUrl":"10.1016/j.neuroscience.2024.11.082","url":null,"abstract":"A decline in mitochondrial functions associated with ageing is the key factor of free radical generation which contributes to age-related pathologies. Protecting healthy functional mitochondrial networks with antioxidants is critical in promoting healthy ageing. This study aimed to investigate the protective effect of ergothioneine (EGT)-rich Lentinula edodes extract (LE-ETH) against tert-butyl hydroperoxide (t-BHP) assaulted senescent HT22 cells. Mitochondrial function was evaluated by measuring mitochondrial membrane potential (MMP), ATP levels and mitochondrial toxicity. The protective mechanisms were elucidated via the exploration of antioxidant and mitochondrial biogenesis signalling pathways. Our results revealed that a low dose of t-BHP increases mitochondrial toxicity. The pretreatment with 100 µg/mL of LE-ETH and the equimolar concentration of EGT for 8 h significantly improve the mitochondrial function and reduced inflammation. Through gene expression studies, we demonstrated that pretreatment of LE-ETH significantly improves the antioxidant and mitochondrial biogenesis pathway via Nrf2 signaling axis. However, the downstream genes of the mitochondrial biogenesis pathway were unaffected by equimolar EGT concentration. Gas chromatography-mass spectrum (GC-MS) analysis was carried out to identify the bioactive compounds that are present in LE-ETH extract which contributed to its efficacy in improving the mitochondrial functions. A total of 23 compounds consisting of phenols, fatty acids, and sterols were identified in the ethanolic extract. Pentanoic acid was the major compound identified in LE-ETH. These findings demonstrated that EGT-rich L.edodes mushroom is a potential neuroprotective agent which could serve as a potential therapeutic strategy for the preservation of mitochondrial functions in healthy ageing explorations.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"277-291"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intricate brain-heart connection: The relationship between heart rate variability and cognitive functioning.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-05 DOI: 10.1016/j.neuroscience.2024.12.004

Giuseppe Forte, Maria Casagrande

{"title":"The intricate brain-heart connection: The relationship between heart rate variability and cognitive functioning.","authors":"Giuseppe Forte, Maria Casagrande","doi":"10.1016/j.neuroscience.2024.12.004","DOIUrl":"10.1016/j.neuroscience.2024.12.004","url":null,"abstract":"In the last years, there has been a growing interest in the brain-heart connection. A core aspect of this connection appears to be the autonomic nervous system, particularly through the vagus nerve. Accordingly, vagally mediated heart rate variability (vmHRV) is currently considered as an index of top-down control processes involved in cognition and emotion regulation. Recent evidence indicates that higher vmHRV is associated with enhanced cognitive performance across multiple domains, such as executive functions, memory, attention, and language skills. From this premises, this study examined the relationship between cardiac vagal tone, as indicated by heart rate variability (vmHRV), and cognitive functions. A sample of 143 healthy young adults completed a comprehensive neuropsychological battery. The results revealed a strong correlation between resting vmHRV and cognitive functions, particularly in executive processes. Participants with higher resting vagal tone showed superior cognitive performance in tasks requiring cognitive control, motor and cognitive inhibition, cognitive flexibility, and working memory in comparison to those with lower resting vagal tone. Furthermore, vagal-mediated heart rate variability was also found to be associated with memory, attention, and executive performance. The current research provides new insights into the interactions between cognitive and autonomic systems, further supporting evidence for body-brain interactions.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"369-376"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular basis of the development of Parkinson's disease.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-07 DOI: 10.1016/j.neuroscience.2024.12.009

Margarita Absalyamova, Dmitrii Traktirov, Viktoria Burdinskaya, Valeria Artemova, Zamira Muruzheva, Marina Karpenko

{"title":"Molecular basis of the development of Parkinson's disease.","authors":"Margarita Absalyamova, Dmitrii Traktirov, Viktoria Burdinskaya, Valeria Artemova, Zamira Muruzheva, Marina Karpenko","doi":"10.1016/j.neuroscience.2024.12.009","DOIUrl":"10.1016/j.neuroscience.2024.12.009","url":null,"abstract":"Parkinson's disease is one of the most prevalent neurodegenerative motor disorders worldwide with postural instability, bradykinesia, resting tremor and rigidity being the most common symptoms of the disease. Despite the fact that the molecular mechanisms of Parkinson's disease pathogenesis have already been well described, there is still no coherent picture of the etiopathogenesis of this disease. According to modern concepts, neurodegeneration is induced mainly by oxidative stress, neuroinflammation, dysregulation of cerebral proteostasis, apoptotic dysregulation, and impaired autophagy. This review describes how various factors contribute to neurodegeneration in Parkinson's disease. Understanding the factors affecting fundamental cellular processes and responsible for disease progression may help develop therapeutic strategies to improve the quality of life of patients suffering from the disease. The review also discusses the role of calpains in the development of Parkinson's disease. It is known that α-synuclein is a substrate of calcium-dependent proteases of the calpain family. Truncated forms of α-synuclein are not only involved in the process of formation of the aggregates, but also increase their toxicity.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"292-300"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of maternal separation stress on ethanol intake and endocannabinoid system in adolescent mice. 母体分离应激对青春期小鼠乙醇摄入量和内源性大麻素系统的影响

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-22 DOI: 10.1016/j.neuroscience.2024.11.037

C A Favoretto, N B Bertagna, A Anjos-Santos, C M Loss, B T Rodolpho, T Righi, F R Bezerra, P C Bianchi, F C Cruz

{"title":"Impacts of maternal separation stress on ethanol intake and endocannabinoid system in adolescent mice.","authors":"C A Favoretto, N B Bertagna, A Anjos-Santos, C M Loss, B T Rodolpho, T Righi, F R Bezerra, P C Bianchi, F C Cruz","doi":"10.1016/j.neuroscience.2024.11.037","DOIUrl":"10.1016/j.neuroscience.2024.11.037","url":null,"abstract":"Clinical and preclinical studies suggest that early life stress can increase the risk of developing ethanol use disorder later in life. Although the endocannabinoid (eCB) system plays a role in stress-related behaviors and ethanol consumption, it remains unclear whether the eCB system is affected in response to a combination of both factors. By using male and female adolescent C57BL/6J mice subjected to a maternal separation (MS) stress paradigm from postnatal day (PND) 1 to 14, we explored (1) the consequences of early life stress experiences on ethanol consumption in adolescent mice and (2) how these events affect the eCB system and neuronal activation in brain regions associated with the reward system. In Experiment 1, we found that MS increased involuntary ethanol consumption specifically during the first exposure to the drug (during a 24 h-long trial on PND 28) and decreased the active/inactive nose poke ratio (discrimination index) specifically when mice were subjected to 1 h-sessions (PND 82-86) in an operant ethanol self-administration paradigm. In Experiment 2, during a two-bottle free choice paradigm, we found that MS increased mice preference for high ethanol concentrations (15 % and 20 %) but not lower ethanol concentrations (5 % and 10 %). Except for Mgll gene expression in the dorsal striatum (DS) in Experiment 2, no statistically significant effects of MS were observed regarding neuronal activation on the prefrontal cortex, DS, globus pallidus, and substantia nigra following a binge operant ethanol self-administration session (Experiment 1) or the eCB system molecules (Cnr1 and Faah gene expression) in the DS (Experiment 2).","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"124-137"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors and predictive models in the progression from MCI to Alzheimer's disease.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-05 DOI: 10.1016/j.neuroscience.2024.11.056

Chang Li, Shike Wang, Yuwei Xia, Feng Shi, Lin Tang, Qingning Yang, Junbang Feng, Chuanming Li

{"title":"Risk factors and predictive models in the progression from MCI to Alzheimer's disease.","authors":"Chang Li, Shike Wang, Yuwei Xia, Feng Shi, Lin Tang, Qingning Yang, Junbang Feng, Chuanming Li","doi":"10.1016/j.neuroscience.2024.11.056","DOIUrl":"10.1016/j.neuroscience.2024.11.056","url":null,"abstract":"Background: The conversion of mild cognitive impairment (MCI) to Alzheimer's disease (AD) is related to various factors. The causal relationships among these factors remain unclear. This study aims to investigate pathways of the progression by using causal analysis and build a predictive model with high accuracy.Methods: 162 MCI patients were recruited from the Alzheimer's Disease Neuroimaging Initiative database. 68 patients progressed to AD. 94 patients did not convert to AD. We captured standard T1-weighted images, processed them for feature extraction, and selected relevant features using mRMR and LASSO to calculate cortical and nuclear scores. The computational causal structure discovery and regression analyses were adopted to analyze the intricate relationships among APOE ε4 alleles, P-tau, Aβ1-42, cortical and nuclear scores. The individualized prediction nomogram was constructed.Results: Our results indicated that APOE ε4 alleles was the promoter that caused MCI to transform into AD. Three independent pathways were identified, including P-tau, Aβ1-42, and cortical atrophy. P-tau was the cause of nuclear atrophy. The APOE ε4 alleles, P-tau, Aβ1-42, cortical and nuclear scores all had good predictive value for the MCI conversion. The predictive accuracy of the combined model was the highest, with an AUC of 0.918 in the training cohort and 0.908 in the testing cohort. A multi-predictor nomogram was established.Conclusion: Our study elucidated the initiating factors and three independent pathways involved in the conversion of MCI to AD. The predictive value of each factor was clarified and a multi-predictor nomogram was established with high accuracy.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"312-319"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dual modulating effects of neuropeptide FF on morphine-induced analgesia at the spinal level.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-07 DOI: 10.1016/j.neuroscience.2024.12.010

Dan Chen, Mengna Zhang, Yongtao He, Shuyuan Wu, Junzhe Kuang, Zixin Zhang, Biao Xu, Quan Fang

{"title":"The dual modulating effects of neuropeptide FF on morphine-induced analgesia at the spinal level.","authors":"Dan Chen, Mengna Zhang, Yongtao He, Shuyuan Wu, Junzhe Kuang, Zixin Zhang, Biao Xu, Quan Fang","doi":"10.1016/j.neuroscience.2024.12.010","DOIUrl":"10.1016/j.neuroscience.2024.12.010","url":null,"abstract":"Increasing evidence indicates that neuropeptide FF (NPFF) produces analgesic effects and augments opioid-induced analgesia at the spinal level. However, our recent research demonstrated that NPFF exerted complex opioid-modulating effects in an inflammatory pain model after intrathecal (i.t.) injection. Consistent with previous findings, we found that i.t. NPFF dose-dependently attenuated complete Freund's adjuvant-induced pain hypersensitivity. Interestingly, pharmacological results illustrated that NPFF exhibited opposite opioid-modulating effects at the spinal level depending on its administration dosage, wherein i.t. NPFF potentiated morphine-induced anti-allodynia at the dose of 10 nmol, while attenuated morphine analgesia at an ultra-low-dose of 10 pmol. Behavioral results obtained from neuropeptide FF receptor 2 (NPFFR2) knockout animals suggested that both pro- and anti-opioid effects of NPFF were mediated by NPFFR2. Moreover, these modulating effects of spinal NPFFR2 were selectively targeting mu-opioid receptor, had no effect on delta- and kappa-opioid receptor agonist-induced analgesia. Finally, the opioid-modulating effects of NPFF were further verified using in vitro calcium imaging assay, demonstrating that pretreated with NPFF in primary-cultured spinal neurons significantly attenuated the inhibitory effects of morphine on high-K+-induced neuronal excitability. Taken together, our results suggested that NPFF exhibited dual modulating effects on morphine-induced analgesia after i.t. administration, which provides a possible mechanism to explain the complex opioid-modulating effects of endogenous NPFF systems.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"247-256"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0