Neuroscience最新文献

{"title":"Electroacupuncture promotes oligodendrocyte differentiation and myelin repair in a rat model of vascular dementia: Investigation of the mechanism from NF-κB-mediated inflammation","authors":"Chang Liu ,&nbsp;Hongyu Yin ,&nbsp;Xiaoyu Chen ,&nbsp;Wenming Ban ,&nbsp;Guoqi Zhu ,&nbsp;Jingji Wang","doi":"10.1016/j.neuroscience.2025.03.002","DOIUrl":"10.1016/j.neuroscience.2025.03.002","url":null,"abstract":"<div><div>Myelin impairment is an important cause of cognitive impairment in vascular dementia (VD). Promoting myelin regeneration has become an important improvement strategy and oligodendrocytes are important targets. This study used a multiple microinfarctions (MMI)-induced VD rat model to reveal the mechanism of myelination of oligodendrocytes in the recovery of VD model, and to investigate the intervention mechanism of electroacupuncture (EA), an effective therapeutic for VD. Initially, our transcriptomic analysis identified 52 differentially expressed genes between the sham and MMI groups. These genes are primarily associated with axonal pathways, including the synaptic vesicle cycle, glutamatergic synapse, axon guidance, and sphingolipid metabolism. Compared with sham group, inflammation, impaired differentiation of oligodendrocyte precursor cells (OPCs) and myelin damage were remarkably observable in the hippocampus of MMI group, indicating the involvement of inflammation-regulated impairment of OPCs. Accordingly, pyrrolidinedithiocarbamate (PDTC), a NF-κB inhibitor could improve learning and memory impairment, reverse the hippocampal inflammation and impairment of OPCs differentiation, and decrease myelin damage in MMI rats. Importantly, EA could also improve learning and memory, attenuate the inflammatory response in the hippocampus and facilitate the differentiation of OPCs to aid in the repair of myelin damage in MMI rats. In conclusion, our data suggest that NF-κB activation is a prohibited factor for the myelin repair, while EA might reduce NF-κB activation and promote the differentiation of OPCs to repair the myelin damage in MMI rats.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 21-34"},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological and functional Characterization of a neonatal mouse model of intraventricular hemorrhage","authors":"Akanksha Mishra ,&nbsp;Bokun Cheng ,&nbsp;Aaina Singh Rathore ,&nbsp;Shreyas Singh ,&nbsp;Praveen Ballabh","doi":"10.1016/j.neuroscience.2025.03.007","DOIUrl":"10.1016/j.neuroscience.2025.03.007","url":null,"abstract":"<div><div>Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is a major neurological problem of premature infants that leads to white matter injury and posthemorrhagic hydrocephalus. There is no optimal treatment for IVH-induced complications. Several animal models of IVH have been developed, but they have significant limitations. We employed a one-day-old C57BL/6 mouse (P1) and injected hemolyzed whole blood or saline into both cerebral ventricles under hypothermia-induced anesthesia. The blood was obtained from one of the C57BL/6 inbred mouse strains. We evaluated a range of parameters, including apoptosis, cerebral inflammation, myelination, ventricle size, and neurobehavioral functions. The weight gain was comparable between blood- and saline-injected mouse pups. The ventricle size and head dimensions were larger in blood-injected pups compared to saline controls at P21 through P60. We demonstrated greater apoptotic cell death, neuronal degeneration, and microglia infiltration in the periventricular white matter of blood-treated pups relative to controls at P3 and P7. Myelination was reduced, and astrogliosis was increased in blood-injected mice relative to saline controls at P21. Post-hemorrhagic hydrocephalus was noted in blood-treated mice at both P21 and P60. Neurobehavior evaluation revealed motor and cognitive deficits in blood-injected animals relative to controls at P60. A comparison between hemolyzed and non-hemolyzed whole blood-treated pups showed that the hemolyzed blood produced more consistent hydrocephalus and reduction in myelination compared to non-hemolyzed blood injections. The study provides comprehensive analyses of a novel model of IVH that can be employed to understand the mechanisms and develop therapeutic strategies for white matter injury and hydrocephalus in IVH survivors.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 56-67"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: In vivo and in silico approaches","authors":"Md. Sakib Al Hasan ,&nbsp;Md. Shimul Bhuia ,&nbsp;Raihan Chowdhury ,&nbsp;Zakir Husain ,&nbsp;Md. Saifuzzaman ,&nbsp;Emon Mia ,&nbsp;Md. Showkoth Akbor ,&nbsp;Noshin Tasnim Yana ,&nbsp;Md. Amirul Islam ,&nbsp;Siddique Akber Ansari ,&nbsp;Irfan Aamer Ansari ,&nbsp;Md. Torequl Islam","doi":"10.1016/j.neuroscience.2025.03.004","DOIUrl":"10.1016/j.neuroscience.2025.03.004","url":null,"abstract":"<div><div>The citrus peel flavonoid tangeretin (TAN) has diverse biological activities, including antioxidant, anti-inflammatory, antitumor, hepatoprotective, and neuroprotective effects. This study investigates the sedative effects of TAN, in Swiss albino mice using <em>in vivo</em> and <em>in silico</em> approaches. TAN (10 and 20 mg/kg, i.p.) was administered alone and in combination with diazepam (DZP, 2 mg/kg, i.p.) and flumazenil (FLU, 0.1 mg/kg, i.p.) to evaluate its impact on thiopental sodium (TS)-induced sleep, locomotor activity, and dark-light behavior. Results demonstrated that TAN at 10 mg/kg significantly (<em>p</em> &lt; 0.05) reduced sleep onset latency and increased sleep duration, with a synergistic effect observed when combined with DZP. In locomotor activity tests, TAN dose-dependently decreased the distance traveled, while the combination with DZP further enhanced this effect. Dark-light tests revealed that TAN increased dark residence time, indicating potential anxiolytic properties. Molecular docking studies showed that TAN binds to the GABA_A receptor (α1 and β2 subunits) with a binding affinity of –6.6 kcal/mol, suggesting its interaction with GABAergic pathways. Pharmacokinetic analysis indicated high intestinal absorption and compliance with Lipinski’s rule of five, with a favorable safety profile (LD₅₀ = 5000 mg/kg). Overall, TAN enhances the sedative effects of DZP through GABA_A receptor modulation, highlighting its potential as a natural sedative agent. Further research should explore the long-term effects, bioavailability, blood–brain barrier permeability, and synergistic interactions of TAN, with comprehensive in vitro studies and clinical trials needed to validate its potential as a natural sedative.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in degree centrality and functional connectivity associated with cognitive Impairment in myotonic dystrophy type 1:A Preliminary functional MRI study","authors":"Sun Qian ,&nbsp;He Di ,&nbsp;Huang Pei ,&nbsp;Hao Zeqi ,&nbsp;Zhang Jiaxi ,&nbsp;Liu Jun ,&nbsp;Jia Xize ,&nbsp;Xue Xiaomeng ,&nbsp;Zhou Haiyan","doi":"10.1016/j.neuroscience.2025.02.040","DOIUrl":"10.1016/j.neuroscience.2025.02.040","url":null,"abstract":"<div><h3>Objectives</h3><div>The study aimed to examine alterations in voxel-based degree centrality (DC) and functional connectivity (FC), and their relationship with cognitive impairments in patients with myotonic dystrophy type 1 (DM1).</div></div><div><h3>Methods</h3><div>Eighteen DM1 patients and eighteen healthy controls participated in the study and were assessed using a comprehensive neuropsychological battery. Voxel-wise DC and FC analyses were used to assess abnormalities in functional connections among aberrant hubs. Correlational analyses were used to identify and explore the relationship between DC and FC values and cognitive performance in DM1 patients.</div></div><div><h3>Results</h3><div>DM1 patients exhibited reduced DC in the bilateral Rolandic operculum, left inferior frontal gyrus (triangular part), right angular gyrus, right median cingulate and paracingulate gyri, and right middle temporal gyrus. Conversely, increased DC was observed in the right fusiform gyrus, right hippocampus and left inferior temporal gyrus. FC analysis revealed that altered connectivity predominantly occurred among the right middle temporal gyrus, right angular gyrus and left inferior frontal gyrus (triangular part). DC value in left inferior temporal gyrus showed significant correlations with scores from the Digital Span Test-Forward (<em>r</em> = -0.556, <em>p</em> = 0.025), the Digital Span Test −Backward (<em>r</em> = -0.588, <em>p</em> = 0.017), the Auditory Verbal Learning Test (<em>r</em> = -0.586, <em>p</em> = 0.017) and the Rey-Osterrieth Complex Figure test (copying version) (<em>r</em> = 0.536, <em>p</em> = 0.032) in DM1 patients. No significant correlations were discovered between FC values and neurocognitive performances.</div></div><div><h3>Conclusion</h3><div>The study demonstrated that abnormalities in DC and FC may become potential neuroimaging biomarkers for cognitive decline in DM1 patients.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 49-55"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tips for quality publishing; lessons from the neuroscience editorial team","authors":"Francesca Cirulli ,&nbsp;Rachael Dangarembezi ,&nbsp;Victor de Lafuente ,&nbsp;Anthony J. Hannan ,&nbsp;Amanda C. Kentner ,&nbsp;Tatsuya Mima ,&nbsp;Laurel Morris ,&nbsp;Sarah J. Spencer ,&nbsp;Long-Jun Wu ,&nbsp;Chen Zhang","doi":"10.1016/j.neuroscience.2025.03.005","DOIUrl":"10.1016/j.neuroscience.2025.03.005","url":null,"abstract":"<div><div>In pursuit of excellence in scholarly publishing, the <strong>Neuroscience</strong> editorial team shares valuable insights that are essential for authors, reviewers, and the broader scientific community. Firstly, we emphasize that impactful research is built on rigorous study design and execution. Beyond fundamental methodological safeguards such as randomization and blinded analysis, we highlight the importance of thoughtfully selecting study models, with deliberate attention to biological variables like sex and gender, as well as appropriate nomenclature. Secondly, as technological innovations reshape research landscapes, we advocate for combining methodological rigor with suitable analytical tools to ensure robust data collection and transparent reporting. Thirdly, for manuscripts reaching the revision stage, we frame the response to reviewers as a strategic process that requires objectivity, diplomacy, and evidence-based rebuttals where necessary. Finally, we call for intentional prioritization of inclusivity and diversity across all stages of scientific inquiry – from laboratory collaborations to editorial decisions – and urge stakeholders to actively counteract implicit biases in manuscript evaluation and citation practices. By embedding these principles into the scientific workflow, we argue that the research community can foster not only greater rigor but also a more equitable and innovative scholarly ecosystem.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 68-72"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Enriched environment promotes similar neuronal and behavioral recovery in a young and aged mouse model of Parkinson’s disease” [Neuroscience 172 (2011) 443–452]","authors":"N.R.S. Goldberg ,&nbsp;A.K. Haack ,&nbsp;C.K. Meshul","doi":"10.1016/j.neuroscience.2025.02.041","DOIUrl":"10.1016/j.neuroscience.2025.02.041","url":null,"abstract":"","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"571 ","pages":"Page 31"},"PeriodicalIF":2.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of deep learning-based high-resolution magnetic resonance to identify intracranial and extracranial symptom-related plaques","authors":"Jinlin Yang ,&nbsp;Pan Xiao ,&nbsp;Yimiao Luo ,&nbsp;Songrui Zhu ,&nbsp;Yu Tang ,&nbsp;Huiyue Chen ,&nbsp;Hansheng Wang ,&nbsp;Fajin Lv ,&nbsp;Tianyou Luo ,&nbsp;Oumei Cheng ,&nbsp;Jin Luo ,&nbsp;Yun Man ,&nbsp;Zheng Xiao ,&nbsp;Weidong Fang","doi":"10.1016/j.neuroscience.2025.02.055","DOIUrl":"10.1016/j.neuroscience.2025.02.055","url":null,"abstract":"<div><div>This study aims to develop a deep learning model using high-resolution vessel wall imaging (HR-VWI) to differentiate symptom-related intracranial and extracranial plaques, which is crucial for stroke treatment and prevention. We retrospectively analyzed HR-VWI data from 235 patients, dividing them into a training set (n = 156) and a testing set (n = 79). Using T1-weighted and contrast-enhanced T1WI images, we constructed five deep learning models and selected the best-performing DenseNet 201 model to extract features. Traditional and radiomics features were also obtained to build both single and combined models. The models were evaluated using receiver operating characteristic curves and the area under the curve (AUC). The deep learning model showed the highest diagnostic performance, while combined models, particularly T + D, performed well, though not better than the single deep learning model. The deep learning model based on HR-VWI is superior in discriminating symptom-related plaques and offers valuable guidance for plaque management.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"571 ","pages":"Pages 130-138"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of three different frequencies of micro-magnetic stimulation on the neuronal electrical activity of the hippocampal CA1 neurons in mice","authors":"Yu Zheng ,&nbsp;Meng Wang ,&nbsp;Lei Dong ,&nbsp;Chunxiao Tian ,&nbsp;Dejiao Qi ,&nbsp;Yazhou Chen","doi":"10.1016/j.neuroscience.2025.02.057","DOIUrl":"10.1016/j.neuroscience.2025.02.057","url":null,"abstract":"<div><div>Frequency is essential in regulating neuroelectric activity using magnetic fields. Current reports focus on 100 Hz or less. Studying other relatively high magnetic stimulation frequencies is necessary to reveal the influence of magnetic stimulation frequency parameters on electrical activity.This paper examined the pyramidal neurons in the CA1 region of the hippocampus of C57 mice. A custom-built micro-magnetic stimulation (<em>μ</em>MS) device with sub-millimeter dimensions was utilized. Three magnetic field frequencies of 15 Hz, 3 kHz, and 70 kHz were chosen at a magnetic field strength of 1 mT. Precision-targeted magnetic stimulation of CA3 area neurons upstream of CA1 by whole-cell membrane clamp method. The effects of three various magnetic stimulation frequencies on the action potential (AP), sodium channel current (I_Na), and transient outward potassium channel current (I_A) of neurons in the hippocampal CA1 area were investigated. 15 Hz inhibited the excitability of pyramidal neurons within the CA1 area; 3 kHz had a facilitating effect, while the 70 kHz magnetic stimulation had a more pronounced facilitating effect. Magnetic field stimulation at 15 Hz decreased neuronal excitability, whereas magnetic field stimulation at 3 and 70 kHz increased neuronal excitability.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"571 ","pages":"Pages 96-107"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid network based on multi-scale convolutional neural network and bidirectional gated recurrent unit for EEG denoising","authors":"Qiang Li ,&nbsp;Yan Zhou ,&nbsp;Junxiao Ren ,&nbsp;Qiao Wu ,&nbsp;Ji Zhao","doi":"10.1016/j.neuroscience.2025.02.035","DOIUrl":"10.1016/j.neuroscience.2025.02.035","url":null,"abstract":"<div><div>Electroencephalogram (EEG) signals are time series data containing abundant brain information. However, EEG frequently contains various artifacts, such as electromyographic, electrooculographic, and electrocardiographic. These artifacts can change EEG waveforms and affect the accuracy and reliability of neuroscientific studies. Recent research has demonstrated that end-to-end deep learning approaches are highly effective in removing artifacts. Despite the widespread use of convolutional neural networks (CNN) for this task, their inability to capture multi-scale and time-dependent features impacts overall denoising performance. Therefore, we propose a hybrid network based on multi-scale CNN and bidirectional gated recurrent unit (MSCGRU) to address those issues. MSCGRU, an improved generative adversarial network, comprises a generator and a discriminator. Firstly, we design a multi-scale convolution module to extract different frequent features from EEG signals. Next, we employ a channel attention mechanism to selectively emphasize important channels and suppress irrelevant ones, enhancing extracted features’ discriminative capability. Then, BiGRU is utilized to extract time-dependency features. The discriminator, a multi-layer convolutional structure, measures the similarity between generated EEG and clean EEG, further improving denoising performance. We compare MSCGRU with other denoising models on publicly available datasets. For electromyographic artifacts, MSCGRU achieves a relative root mean square error of <span><math><mrow><mn>0</mn><mo>.</mo><mn>277</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>009</mn></mrow></math></span>, a correlation coefficient of <span><math><mrow><mn>0</mn><mo>.</mo><mn>943</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>004</mn></mrow></math></span>, and a signal-to-noise ratio of <span><math><mrow><mn>12</mn><mo>.</mo><mn>857</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>294</mn></mrow></math></span>. Results demonstrate that MSCGRU outperforms other models. This paper provides a new method to reconstruct clean EEG and may further benefit the EEG-based diagnosis and treatment.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 155-170"},"PeriodicalIF":2.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity transcranial ultrasound stimulation modulates neurovascular coupling in mice under propofol anesthesia","authors":"Guangying Cui ,&nbsp;Yi Yuan ,&nbsp;Qiaoxuan Wang ,&nbsp;Li Zhao ,&nbsp;Cheng Chi ,&nbsp;Liqiang Zhao ,&nbsp;Zhuo Liu","doi":"10.1016/j.neuroscience.2025.02.045","DOIUrl":"10.1016/j.neuroscience.2025.02.045","url":null,"abstract":"<div><h3>Background</h3><div>Studies have reported that low-intensity transcranial ultrasound stimulation (LI-TUS) can modulate the emergence from anesthesia. Dynamic changes in neurovascular coupling during anesthesia continuously coordinate spatial cerebral blood flow. How LI-TUS modulates neurovascular coupling to alter anesthesia need to be elucidated.</div></div><div><h3>Methods</h3><div>Sixteen healthy BALB/c mice were divided into the transcranial ultrasound stimulation (TUS) group (n = 8) and the Sham group (n = 8). After a surgical procedure, mice were intraperitoneally injected with propofol. Mice in the TUS group were stimulated by transcranial ultrasound. Electroencephalogram, cerebrovascular images of the cortex, and electromyography were recorded. The changes of these indicators were analyzed using optical intrinsic signal imaging and electrophysiological acquisition.</div></div><div><h3>Results</h3><div>We found that LI-TUS shortened the awakening time in the TUS group. Furthermore, the following changes in the TUS group were observed: (1) During the period of recovery from anesthesia, the relative change in cerebrovascular deoxyhemoglobin was decreased at TUS-10 min, TUS-15 min and TUS-20 min; (2) During the deep anesthesia phase, the relative change of mean absolute power of local field potentials was increased at [4–8 Hz], [8–13 Hz], [13–30 Hz], and [30–60 Hz] frequency bands. Furthermore, the Pearson correlation coefficients between the relative change of mean absolute power at [60–90 Hz] frequency band and the relative change in cerebrovascular deoxyhemoglobin were smaller in the TUS group.</div></div><div><h3>Conclusion</h3><div>LI-TUS shorten the time of awakening in mice under propofol anesthesia, which may due to LI-TUS energized the neural activity, increased cerebral blood flow, improved the cerebral blood oxygenation and neurovascular coupling.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 73-83"},"PeriodicalIF":2.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}