Neuroscience最新文献

{"title":"Microbial infection instigates tau-related pathology in Alzheimer’s disease via activating neuroimmune cGAS-STING pathway","authors":"Xiaoxu Yan ,&nbsp;Erlin Wang ,&nbsp;Meng Zhao ,&nbsp;Guanqin Ma ,&nbsp;Xiang-Xiong Xu ,&nbsp;Jie-Bin Zhao ,&nbsp;Xiaohong Li ,&nbsp;Jianxiong Zeng ,&nbsp;Xueling Ma","doi":"10.1016/j.neuroscience.2025.03.019","DOIUrl":"10.1016/j.neuroscience.2025.03.019","url":null,"abstract":"<div><div>Microbial infection, the strong trigger to directly induce inflammation in brain, is long considered a risk factor of Alzheimer’s disease (AD), but how these infections contribute to neurodegeneration remains underexplored. To examine the effect of herpes simplex virus type 1 (HSV-1) infection on tauopathy in local hippocampus of P301S mice, we utilized a modified HSV-1 strain (mHSV-1) potentially relevant to AD, we found that its infection promotes tau-related pathology in part via activating neuroimmune cGAS-STING pathway in the tau mouse model. Specifically, <em>Sting</em> ablation causes the detectable improvement of neuronal dysfunction and loss in P301S mice, which is causally linked to lowered proinflammatory status in the brain. Administration of STING inhibitor H-151 alleviates neuroinflammation and tau-related pathology in P301S mice. These results jointly suggest that herpesviral infection, as the vital environmental risk factor, could induce tau-related pathology in AD pathogenesis partially via neuroinflammatory cGAS-STING pathway.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 122-133"},"PeriodicalIF":2.9,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma lipidome and intracranial aneurysms: A univariable and multivariable Mendelian randomization study","authors":"Xinke Liu ,&nbsp;Dachao Wei ,&nbsp;Jun Lin ,&nbsp;Linggen Dong ,&nbsp;Youxiang Li ,&nbsp;Ming Lv","doi":"10.1016/j.neuroscience.2025.03.018","DOIUrl":"10.1016/j.neuroscience.2025.03.018","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies suggest that plasma lipids, including lipoproteins and fatty acids, may contribute to the pathogenesis of intracranial aneurysms (IAs). However, the relationship between a broader range of plasma lipids and IA risk remains unclear. This study uses the Mendelian randomization (MR) approach to explore the causal relationships between 179 plasma lipids and the risk of IAs.</div></div><div><h3>Methods</h3><div>We used summary statistics from a study of 7174 individuals to examine 179 plasma lipids. Data on IAs and aneurysmal subarachnoid hemorrhage (aSAH) were drawn from a study by Bakker MK et al., which included 2070 cases of unruptured IAs, 5 140 cases of aSAH, and 71,934 controls. MR analyses were conducted using inverse variance-weighted as the primary method, with weighted median, weighted mode, and MR-Egger as additional methods. To prioritize lipid risk factors, we applied multivariable Mendelian randomization–Bayesian model averaging.</div></div><div><h3>Results</h3><div>We identified 5 plasma lipids associated with IAs and 4 with aSAH. Phosphatidylcholine (14:0_18:2) was significantly associated with both IAs and aSAH, with odds ratios of 1.44 (95 % confidence interval [CI] 1.17–1.77, P_adjusted = 0.036) for IAs and 1.53 (95 % CI 1.20–1.94, P_adjusted = 0.036) for aSAH. In multivariable MR, phosphatidylcholine (14:0_18:2) and phosphatidylcholine (18:0_20:3) emerged as the strongest risk factors for IAs and aSAH, respectively.</div></div><div><h3>Conclusion</h3><div>Our study identifies specific plasma lipids, particularly phosphatidylcholine (14:0_18:2) and phosphatidylcholine (18:0_20:3), as significant risk factors for IAs and aSAH. These findings suggest that phosphatidylcholines could serve as predictive biomarkers for aneurysm risk. Further research is needed to validate these associations and clarify the underlying mechanisms.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"573 ","pages":"Pages 1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alteration of cortical structure and functional connectivity in childhood trauma","authors":"Chengming Wang ,&nbsp;Shufei Zhang ,&nbsp;Yunjun Yang ,&nbsp;Zhifeng Xu ,&nbsp;Zezhi Li ,&nbsp;Wei Zheng ,&nbsp;Huawang Wu","doi":"10.1016/j.neuroscience.2025.03.016","DOIUrl":"10.1016/j.neuroscience.2025.03.016","url":null,"abstract":"<div><div>Childhood trauma acts as an independent risk factor for mental disorders. This study utilized multi-modal MRI techniques to integrate cortical structural measurements and functional connectivity (FC) to identify neurobiological markers of trauma. This study recruited 215 participants, divided into a trauma group (n = 57) and a well-matched non-trauma group (n = 158) based on the childhood trauma questionnaire. We compared differences in cortical volume (CV) and surface area (SA) between the groups and performed a seed-based FC analysis using seeds at identified structural clusters. A machine learning approach with logistic regression was employed to classify individuals with and without childhood trauma. The childhood trauma group showed uniformly lower SA and CV. Reduced SA was found in a cluster consisting of the left precentral gyrus, postcentral gyrus, and paracentral lobule, and decreased CV was observed in a cluster involving the left postcentral gyrus. Seed-based FC analyses revealed decreased FC between the CV-cluster and regions of the bank of the superior temporal sulcus, inferior parietal gyrus, and supramarginal gyrus. In contrast, SA-related clusters showed increased FC with the left postcentral gyrus, superior parietal gyrus, and supramarginal gyrus. The logistic regression model, based on these structural and functional features, achieved a statistically significant classification accuracy of 78 % (<em>p</em> &lt; 0.001) in distinguishing groups with and without childhood trauma. The childhood trauma group exhibits abnormalities in cortical structure and FC which are related to aberrant emotional and cognitive functions. These findings may serve as neuroimaging biomarkers of childhood trauma.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 182-189"},"PeriodicalIF":2.9,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of radiomics and deep transfer learning models to assess cognitive impairment in patients with cerebral small vessel disease","authors":"Wei Zheng ,&nbsp;Qi Wu ,&nbsp;Ronghua Mu ,&nbsp;Jia Kuang ,&nbsp;Peng Yang ,&nbsp;Jian Lv ,&nbsp;Bingqin Huang ,&nbsp;Xin Li ,&nbsp;Fuzhen Liu ,&nbsp;Zhixuan Song ,&nbsp;Xiaoyan Qin ,&nbsp;Xiqi Zhu","doi":"10.1016/j.neuroscience.2025.03.012","DOIUrl":"10.1016/j.neuroscience.2025.03.012","url":null,"abstract":"<div><div>Cognitive impairment in cerebral small vessel disease (CSVD) progresses subtly but carries significant clinical consequences, necessitating effective diagnostic tools. This study developed and validated predictive models for CSVD-related cognitive impairment using deep transfer learning (DTL) and radiomics features extracted from hippocampal 3D T1-weighted MRI. A total of 145 CSVD patients and 99 control subjects were enrolled in the study. We employed an automated algorithm to segment the hippocampus from 3D T1 images. Pre-trained deep learning networks were utilized to extract DTL features. Feature selection was performed using the Spearman rank correlation test and least absolute shrinkage and selection operator (LASSO) regression. Machine learning classification models, including Random Forest and Naive Bayes, were trained on the selected features. The predictive performance of these models was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC) and decision curve analysis (DCA). The DTL model based on the ResNet101_32x8d network exhibited superior performance compared to other DTL models and the radiomics model, achieving an AUC of 0.847 (95 % CI: 0.691–1.000) and accuracy of 0.760. Furthermore, a combined model integrating ResNet101_32x8d and radiomic features further improved performance (AUC = 0.873, accuracy = 0.800), although the Delong test did not show statistical significance between models. These findings highlight that comprehensive data encompassing radiomics and DTL features showcase a robust predictive capability in distinguishing CSVD patients with cognitive impairment, offering insights for clinical applications despite limitations in sample size.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 145-154"},"PeriodicalIF":2.9,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an open-source hand laterality judgement task for in-person and online studies","authors":"Marcos Moreno-Verdú,&nbsp;Siobhán M. McAteer,&nbsp;Baptiste M. Waltzing,&nbsp;Elise E. Van Caenegem,&nbsp;Robert M. Hardwick","doi":"10.1016/j.neuroscience.2025.02.056","DOIUrl":"10.1016/j.neuroscience.2025.02.056","url":null,"abstract":"<div><div>The Hand Laterality Judgement Task (HLJT) is considered a measure of the ability to manipulate motor images. The ‘biomechanical constraints’ effect (longer reaction times for hand rotations towards anatomically difficult versus biomechanically easier movements) is considered the behavioural hallmark indicating motor imagery is being used. Previous work has used diverse HLJT paradigms, and there is no standardized procedure for the task. We developed an open-source, freely available version of the HLJT in PsychoPy2, which needs no programming skills and is highly customisable. Some studies suggest responding to the HLJT with the hands may interfere with performance, which would limit practical application of the task. We examined this potential issue using in-person and online versions. For the in-person version, 40 right-footed/handed individuals performed the HLJT with their feet or bimanually (N = 20 each). For the online version, 60 right-handed individuals performed the task bimanually or unimanually (N = 20 each). Bayesian mixed-effect analyses quantified the evidence for and against equivalence within and between the in-person and online versions. Both versions replicated previously described behavioural phenomena, including effects of angle, hand view, and the ‘biomechanical constraints’ effect. While responding with different effectors modified overall reaction times, it did not interact with other factors analysed, and did not affect accuracy or the ‘biomechanical constraints’ effect. There was also evidence for equivalence between in-person and online bimanual groups for all measures. We conclude that this open-source, standardized HLJT protocol (available at <span><span>https://osf.io/8h7ec/</span><svg><path></path></svg></span>) can reliably detect previously identified effects and works equally well in-person or online.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 93-107"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-124-mediated temozolomide sensitivity and DNA repair modulation in Glioblastoma Multiforme","authors":"Maryam Mafi Golchin ,&nbsp;Ehsan Arefian ,&nbsp;Zahra Fekrirad ,&nbsp;Gholamreza Hashemi Tabar","doi":"10.1016/j.neuroscience.2025.03.010","DOIUrl":"10.1016/j.neuroscience.2025.03.010","url":null,"abstract":"<div><div>Glioblastoma Multiforme (GBM) is the most frequent and invasive primary malignant brain tumor. One approach to improve the effectiveness of GBM treatment is the combination of miRNA-targeted therapy with TMZ. This study aimed to assess the effect of miR-124 overexpression on TMZ resistance in GBM cell lines. Additionally, we examined how miR-124 overexpression affects the expression of genes involved in DNA repair processes. We conducted a bioinformatics prediction for target genes of miR‑124‑3p and then overexpressed miR-124 in U-87 and U-251 cell lines through lentiviral transduction. Sixty genes were identified as potential targets of miR-124-3p, which revealed overlap among 504 target mRNAs and upregulated genes across four GEO datasets. <em>PRRX1</em>, <em>ETS</em>, <em>VIM</em>, and <em>PTBP1</em> genes were selected based on their contributions to DNA repair and related processes such as autophagy including <em>Beclin-1</em> and <em>Atg-5</em>. The MTT assay results showed that only the U87 cell line overexpressing miR-124 exhibited significantly greater sensitivity to TMZ treatment. The qRT-PCR analysis revealed a significant reduction in mRNA levels of all DNA repair-related genes and two autophagy-related genes in both cell lines. The results might indicate that after TMZ-induced genomic damage, cells activate the DNA repair pathways, ultimately leading to the development of resistance. In the context of TMZ treatment, autophagy is considered a protective process for cancer cells, and definitive proof of its association with the anti-cancer activity of miR-124 requires further supplementary tests. So, modulating DNA repair pathways with miR-124 could enhance the chemosensitivity of Glioma cells to TMZ.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"573 ","pages":"Pages 52-63"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant white matter function and structure in Rhegmatogenous retinal detachment: A study utilizing functional network clustering and TractSeg methods","authors":"Yu Ji ,&nbsp;Ben-Liang Shu ,&nbsp;Zhuo-Er Dong,&nbsp;Bin Wei,&nbsp;Qin-Yi Huang,&nbsp;Lin Zhou,&nbsp;Hua Chai,&nbsp;Hao-Yu Yuan,&nbsp;Yi-Chong Duan,&nbsp;Li-Li Yao,&nbsp;Xiao-Rong Wu","doi":"10.1016/j.neuroscience.2025.03.013","DOIUrl":"10.1016/j.neuroscience.2025.03.013","url":null,"abstract":"<div><div>Rhegmatogenous retinal detachment (RRD) has been linked to abnormal functional changes in visual pathways and gray matter regions; however, alterations in white matter (WM) function and structure remain poorly understood. Using functional clustering networks and TractSeg methodologies, we investigated WM alterations in RRD patients and employed Support Vector Machine (SVM) algorithms for classification. RRD patients demonstrated reduced functional covariance connectivity (FCC) between the Superior Temporal Network and the Cerebellar Network, along with increased WM amplitude in the Anterior Corpus Callosum Network. Distinct differences in WM fiber bundles associated with visual and cognitive functions were observed, with visual acuity negatively correlating with amplitudes in the Occipital Networks. The SVM model based on WM7_amplitude achieved the highest AUC, highlighting its potential as a neurobiological marker for distinguishing RRD patients from healthy controls (HCs). These findings reveal critical disruptions in WM functional and structural integrity linked to cognitive and visual deficits in RRD, offering novel insights into the neural mechanisms underlying these impairments.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"575 ","pages":"Pages 36-47"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subunit specific altered expression and activity of casein kinase 2 in the brain tissues resected from mesial temporal lobe epilepsy with hippocampal sclerosis patients & rodent temporal lobe epilepsy model","authors":"Priya Priya ,&nbsp;Arpna Srivastava ,&nbsp;Nitin Yadav ,&nbsp;Radhika Mittal ,&nbsp;Sneha Anand ,&nbsp;Jyotirmoy Banerjee ,&nbsp;Manjari Tripathi ,&nbsp;Poodipedi Sarat Chandra ,&nbsp;Ramesh Doddamani ,&nbsp;Mehar Chand Sharma ,&nbsp;Sanjeev Lalwani ,&nbsp;Fouzia Siraj ,&nbsp;Aparna Banerjee Dixit","doi":"10.1016/j.neuroscience.2025.03.001","DOIUrl":"10.1016/j.neuroscience.2025.03.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Mesial temporal lobe epilepsy (MTLE), is associated with dysregulated excitatory-inhibitory balance in the brain. Numerous enzymes, protein kinases, that are modulated through phosphorylation, have been linked with key processes involved in the pathogenesis of epilepsy. Therefore, in this study, we determined the subunit specific expression and activity of multi-subunit casein Kinase 2 (CK2) which influences NMDARs through phosphorylation events, in MTS patients as well as pilocarpine model of TLE.</div></div><div><h3>Methods</h3><div>mRNA expression of CK2 (α, α’, β) &amp; NR2B was measured by real time PCR and<!--> <!-->protein expression of CK2 (α, α’, β), NR2B, and NR2B Ser1480 were evaluated using western blotting and immunohistochemistry in experimental models of TLE and MTS patients. CK2 α and α’ activity was measured by kinase assay.</div></div><div><h3>Results</h3><div>Significant increase in CK2α’, CK2β, and NR2B mRNA expression were noted in chronic TLE rat model. Similarly, MTS patients displayed upregulated CK2α’ and CK2β expressions, but NR2B mRNA remained unchanged. CK2α’, CK2β, and NR2B Ser1480 protein expressions were higher in chronic TLE and MTS patients in relation to controls (p &lt; 0.05), as was kinase activity (p &lt; 0.05). In acute TLE rats, only NR2B protein expression was upregulated (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Our research demonstrated for the first time the upregulation of CK2α’ subunit and its increased kinase activity<!--> <!-->in resected brain samples from MTS patients as well as pilocarpine model of TLE. Altered expression and higher activity of CK2 α’ highlights subunit specific contribution, suggesting the modulation of NMDA receptors by Casein Kinase 2 may contribute to hyperexcitability in MTLE.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 108-121"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptin as a potential neuroprotective target in Parkinson’s Disease: Exploring its role in Neuroinflammation, oxidative Stress, and dopaminergic neurodegeneration","authors":"Vipul Sharma ,&nbsp;Bhat Zada Unjum Saqib ,&nbsp;Khadga Raj Aran","doi":"10.1016/j.neuroscience.2025.03.008","DOIUrl":"10.1016/j.neuroscience.2025.03.008","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is the second most common<!--> <!-->neurodegenerative disease, characterized by<!--> <!-->bradykinesia, resting tremor, stiffness, and postural instability<!--> <!-->resulting due to the progressive loss of<!--> <!-->dopaminergic neurons in the substantia nigra (SN). The pathophysiology of PD<!--> <!-->is extremely complex and involves mitochondrial dysfunction, oxidative stress, neuroinflammation, and disruption of protein homeostasis. Its progression is affected by both environmental and genetic factors, including mutations in the alpha-synuclein (SNCA), PTEN-induced kinase 1 (PINK1), and leucine-rich repeat kinase 2 (LRRK2) genes. Leptin, primarily secreted by the adipose tissue, has garnered significant interest for its involvement in neuroprotective mechanisms and potential role in the progression of PD. Its receptors located in the SN and hippocampus region indicate its role in neuronal survival and function. The role of leptin in the central nervous system (CNS) highlights its impact on neuroinflammation, oxidative stress, and synaptic plasticity. Recent studies indicate that through activation of Janus kinase/signal transducer and activator of transcription (JAK2/STAT3) and the phosphoinositide 3 kinase (PI3 K)/Akt pathways, leptin may exert a neuroprotective effect by preventing the degeneration of dopaminergic neurons, which marked as the hallmark in the pathophysiology of PD. Additionally, leptin’s interaction with neurotrophic factors and its ability to enhance synaptic plasticity highlight its vital role in preserving neuronal health. This review summarizes the role of leptin as a neuroprotective mechanism in PD and explores its potential role as a therapeutic target for treatment to enhance neuroprotection and clinical outcome, by addressing the neurodegenerative characteristics associated with PD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 134-144"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taking flight, the use of Drosophila melanogaster for neuroscience research in Uruguay","authors":"Gonzalo Budelli ,&nbsp;María José Ferreiro ,&nbsp;Carmen Bolatto","doi":"10.1016/j.neuroscience.2025.03.006","DOIUrl":"10.1016/j.neuroscience.2025.03.006","url":null,"abstract":"<div><div>The Sociedad de Neurociencias del Uruguay is celebrating its 30th anniversary, sustained by more than a century of neuroscience research in the country. During this time, different approaches and experimental organisms have been incorporated to study diverse aspects of neurobiology. One of these experimental animals, successfully used in a variety of biological fields, is the fruit fly <em>Drosophila melanogaster</em>. Although <em>Drosophila</em> has been a model organism for neuroscience research worldwide for many decades, its use in Uruguay for that purpose is relatively new and just taking flight. In this special issue article, we will describe some of the research lines that are currently using <em>Drosophila</em> for neuroscience studies, questioning a wide range of issues including thermoreception, neurodegenerative diseases such as Parkinson's, screening of bioactive compounds with a neuroprotective effect, and gene/protein function during development of the nervous system.</div><div>The consolidation of these research lines has been achieved due to unique features of <em>D. melanogaster</em> as an experimental model. We will review the advantages of using <em>Drosophila</em> to study neurobiology and describe some of its useful genetic tools. Advantages such as having powerful genetics, highly conserved disease pathways, a complete connectome, very low comparative costs, easy maintenance, and the support of a collaborative community allowing access to a vast toolkit, all make <em>D. melanogaster</em> an ideal model organism for neuroscientists in countries with low levels of investment in research and development. This review focuses on the strengths and description of useful techniques to study neurobiology using <em>Drosophila</em>, from the perspective of a Latin-American experience.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"573 ","pages":"Pages 104-119"},"PeriodicalIF":2.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}