Neuroscience最新文献_第9页

Alpha rhythm transcranial electrical stimulation to inferior parietal cortex increases alpha power and phase synchrony while attending to mind–body self-states

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-19 DOI: 10.1016/j.neuroscience.2025.01.013

Zhongjie Bao , Paul Frewen

{"title":"Alpha rhythm transcranial electrical stimulation to inferior parietal cortex increases alpha power and phase synchrony while attending to mind–body self-states","authors":"Zhongjie Bao , Paul Frewen","doi":"10.1016/j.neuroscience.2025.01.013","DOIUrl":"10.1016/j.neuroscience.2025.01.013","url":null,"abstract":"<div><div>Self-referential processing (SRP) refers to the human brain’s response to semantic and somatic self-related information. Recent developments in modulating semantic and somatic SRP using non-invasive brain stimulation supported the efficacy of transcranial direct current stimulation in modulating alpha electroencephalography (alpha-EEG) during SRP. Meanwhile, although alpha transcranial alternating current stimulation (alpha-tACS) shows greater efficacy in modulating alpha-EEG, the efficacy of alpha-tACS for modulating alpha-EEG during SRP has not been evaluated. The current study investigates the effects of alpha-tACS compared to sham stimulation over the medial prefrontal cortex and the bilateral inferior parietal lobule on alpha-EEG during both semantic and somatic SRP in two separate experiments. Semantic SRP was provoked by introspection on life roles (e.g., “friend”), while somatic SRP was provoked by interoception upon sensations occurring in the exterior body (e.g., “shoulders”) during the experimental task, and alpha-EEG responses during SRP were compared to those occurring during resting state and an external attention control condition. Results indicated that while alpha-tACS to the medial prefrontal cortex did not produce significant source-level alpha-EEG changes, alpha-tACS to inferior parietal cortex increased alpha-EEG source power and phase synchrony when participants received real stimulation during the first experimental session. An exploratory analysis also indicated that real stimulation reduced alpha-EEG power during semantic but not somatic SRP during the first session but not the second session. Our results demonstrate that while alpha-tACS can modulate alpha-EEG during SRP, the effects may be dependent on the ordering of real vs. sham stimulation sessions and stimulation sites.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"570 ","pages":"Pages 173-184"},"PeriodicalIF":2.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glial vascular Unit as a bridge between Blood-Brain Barrier and glymphatic System: Roles in sepsis-associated encephalopathy

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-19 DOI: 10.1016/j.neuroscience.2025.02.039

Jiyun Hu, Shucai Xie, Tao Chen, Ya Liao, Zhaoxin Qian, Lina Zhang

引用次数: 0

Robotic thread-assisted clot removal for stroke treatment: A comprehensive review

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-19 DOI: 10.1016/j.neuroscience.2025.02.046

K. Sandhanam , Damanbhalang Rynjah , Shatabdi Ghose , Ram Kumar Sahu , Abdul Baquee Ahmed , M. Sumitra , Damiki Laloo , Bedanta Bhattacharjee

{"title":"Robotic thread-assisted clot removal for stroke treatment: A comprehensive review","authors":"K. Sandhanam , Damanbhalang Rynjah , Shatabdi Ghose , Ram Kumar Sahu , Abdul Baquee Ahmed , M. Sumitra , Damiki Laloo , Bedanta Bhattacharjee","doi":"10.1016/j.neuroscience.2025.02.046","DOIUrl":"10.1016/j.neuroscience.2025.02.046","url":null,"abstract":"<div><div>Stroke is the predominant factor of long-term impairment in developed nations and is a major contributor to death globally. Stroke is a life-threatening neurological condition caused by the occlusion or rupture of blood vessels in the brain. Brain clot restricts blood movement by causing obstruction thus, damaging the blood vessels and tissues, which ultimately causes stroke. Thus, stroke requires immediate and efficient treatment to reduce neurological deterioration and increase patient recuperation. Over the last decade, there have been significant breakthroughs in diagnostic and therapeutic interventionsfor stroke. Stroke is typically treated with immediate therapeutic interventions, which may involve thrombolytic medication infusions like tissue plasminogen activator, anti-coagulants like heparin, or surgical clot clearance procedures like thrombectomy. Despite the significant benefits of these treatments, several disadvantages, including restricted therapeutic index, allergic reactions, and adverse effects (such as hypotension, recurrent stroke, hypoglycaemia, and atypical bleeding), highlight the need for far more innovative solutions. In response to these challenges, a novel approach to treating brain clots has emerged. The study investigates a novel approach to treating strokes caused by brain clots through the utilization of a steerable micro-robotic thread guided by real-time imaging to enhance precision in clot removal. This method addresses the limitations of traditional treatments namely thrombolytics and thrombectomy. In this work, we emphasized the innovative approaches in the removal of brain clots, the use and mechanisms of cutting-edge robotic thread technology, and presented specific case studies demonstrating its application.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"570 ","pages":"Pages 95-109"},"PeriodicalIF":2.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and functional differences between hippocampal and cortical microglia and its impact on neuronal over-excitation in a germline Pten mutant mouse model

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-19 DOI: 10.1016/j.neuroscience.2025.02.044

Zhibing Tan , Parker L. Bussies , Nicholas B. Sarn , Muhammad Irfan , Tara DeSilva , Charis Eng

{"title":"Morphological and functional differences between hippocampal and cortical microglia and its impact on neuronal over-excitation in a germline Pten mutant mouse model","authors":"Zhibing Tan , Parker L. Bussies , Nicholas B. Sarn , Muhammad Irfan , Tara DeSilva , Charis Eng","doi":"10.1016/j.neuroscience.2025.02.044","DOIUrl":"10.1016/j.neuroscience.2025.02.044","url":null,"abstract":"<div><div>High-throughput, transcriptomic analyses of the brain have revealed significant differences of microglia between the hippocampus and the cortex. However, it remains unclear whether these regional differences translate into different microglial behaviors and impact disease progression. Here, we show that microglia possess higher morphological complexity and phagocytic capacity in the hippocampus compared to the cortex of wild-type mice. These regional differences are preserved in mice harboring a germline <em>Pten</em> mutation, which have a general increase of microglial ramification and phagocytic capacity. Moreover, we find that <em>Pten</em>-mutant microglia protect neurons from over-excitation through pruning excessive excitatory synapses and forming more microglia-neuron junctions. However, <em>Pten</em>-mutation induced neuronal over-excitation is normalized in the hippocampus but not the cortex which we are attributing to regional differences of microglia in both function and morphology. These <em>Pten</em>-mutant microglia may protect <em>Pten</em> mutant mice from developing spontaneous seizures, but cannot eliminate their heightened risk of provoked seizure. Collectively, our findings have revealed a potential protective role of microglia in an over-excited brain, underscoring the impact of microglial regional heterogeneity in disease development and highlighting their prospect as a therapeutic target for epilepsy.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"570 ","pages":"Pages 159-172"},"PeriodicalIF":2.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic effects of intraarterial injection of imipenem cilastatin sodium in a rat model of knee osteoarthritis.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-18 DOI: 10.1016/j.neuroscience.2025.02.034

Yuki Matsuyama, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Hidenobu Tamai, Ryo Taiji, Takeru Ueno, Ryo Miyake, Takashi Shimoe, Terumasa Nakatsuka, Gen Yamada, Kentaro Suzuki, Hiroshi Yamada

{"title":"Analgesic effects of intraarterial injection of imipenem cilastatin sodium in a rat model of knee osteoarthritis.","authors":"Yuki Matsuyama, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Hidenobu Tamai, Ryo Taiji, Takeru Ueno, Ryo Miyake, Takashi Shimoe, Terumasa Nakatsuka, Gen Yamada, Kentaro Suzuki, Hiroshi Yamada","doi":"10.1016/j.neuroscience.2025.02.034","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.02.034","url":null,"abstract":"<p><p>Angiogenesis is involved in the underlying musculoskeletal pain mechanism; therefore, embolization of blood vessels is expected to have an analgesic effect. We investigated the analgesic effect of intraarterial administration of imipenem cilastatin sodium (IPM/CS) in knee osteoarthritis (OA) model rats using behavioral measures and in vivo patch-clamp recording. To develop the knee OA model, monosodium iodoacetate (MIA) was administered to the right knee joint. First, we infused IPM/CS in the right femoral artery and investigated the knee joint mechanical pressure threshold using a digital device. Next, the nociceptive signals originating from the knee were analyzed via the spontaneous excitatory postsynaptic current (sEPSC) record within the neural cells in the dorsal spinal horn using the in vivo patch-clamp approach. In knee OA rats, the mechanical thresholds at the damaged knee were decreased compared with those of the contralateral knee, whereas these thresholds remained stable in the sham group. The pressure threshold of knee OA rats was significantly increased following intraarterial infusion of IPM/CS but not saline. However, the pain thresholds of knee OA rats were unaltered. A notable rise in the average sEPSC frequency was detected in knee OA rats compared with the sham group. The sEPSC decreased in knee OA rats following intraarterial infusion of IPM/CS but not saline. These results indicated that intraarterial infusion of IPM/CS attenuated pain caused by knee OA. Hence, this method could serve as a strategy for pain alleviation in patients with knee osteoarthritis.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic literature review of machine learning techniques for the detection of attention-deficit/hyperactivity disorder using MRI and/or EEG data 利用磁共振成像和/或脑电图数据检测注意力缺陷/多动症的机器学习技术的系统性文献综述。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-18 DOI: 10.1016/j.neuroscience.2025.02.019

Dhruv Chandra Lohani, Vaishali Chawla, Bharti Rana

{"title":"A systematic literature review of machine learning techniques for the detection of attention-deficit/hyperactivity disorder using MRI and/or EEG data","authors":"Dhruv Chandra Lohani, Vaishali Chawla, Bharti Rana","doi":"10.1016/j.neuroscience.2025.02.019","DOIUrl":"10.1016/j.neuroscience.2025.02.019","url":null,"abstract":"<div><div>Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition common in teenagers across the globe. Neuroimaging and Machine Learning (ML) advancements have revolutionized its diagnosis and treatment approaches. Although, the researchers are continuously developing automated ADHD diagnostic tools, there is no reliable ML-based diagnostic system for clinicians. Thus, the study aims to systematically review ML and DL-based approaches for ADHD diagnosis, leveraging brain data from magnetic resonance imaging (MRI) and electroencephalogram (EEG) data. A methodical review for the period 2016 to 2022 is conducted by following the PRISMA guidelines. Four reputable repositories, namely PubMed, IEEE, ScienceDirect, and Springer are searched for the related literature on ADHD diagnosis using MRI/EEG data. 87 studies are selected after screening abstracts of the papers. We critically conducted an analysis of these studies by examining various aspects related to training ML/DL-models, including diverse datasets, hyperparameter tuning, overfitting, and interpretability. The quality and risk assessment is conducted using the QUADAS2 tool to determine the bias due to patient selection, index test, reference standard, and flow and timing. Our rigours analysis observed significant diversity in dataset acquisition and its size, feature extraction and selection techniques, validation strategies and classifier choices. Our findings emphasize the need for generalizability, transparency, interpretability, and reproducibility in future research. The challenges and potential solutions associated with integrating diagnostic models into clinical settings are also discussed. The identified research gaps will guide researchers in developing a reliable ADHD diagnostic system that addresses the associated challenges.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"570 ","pages":"Pages 110-131"},"PeriodicalIF":2.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prok2/PKR signaling regulates ferroptosis after spinal cord injury

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-18 DOI: 10.1016/j.neuroscience.2025.02.030

Qiancheng Zhu , Tianli Xu , Qun Huang , Qi Gu , Jin Wang , Yi Zhu , Liming Wang , Weiping Sha , Rong Gao , Jianfei Ge , Xiaolong Lin

{"title":"Prok2/PKR signaling regulates ferroptosis after spinal cord injury","authors":"Qiancheng Zhu , Tianli Xu , Qun Huang , Qi Gu , Jin Wang , Yi Zhu , Liming Wang , Weiping Sha , Rong Gao , Jianfei Ge , Xiaolong Lin","doi":"10.1016/j.neuroscience.2025.02.030","DOIUrl":"10.1016/j.neuroscience.2025.02.030","url":null,"abstract":"<div><div>Spinal cord injury (SCI) is a severe traumatic condition that often results in significant disability and death. SCI also causes secondary damage in the acute phase due to neuronal cell death. SCI has been linked to ferroptosis, a new type of cell death. Prokineticin 2 (Prok2) and its receptors (PKR1 and PKR2) are involved in various physiological processes and have been shown to regulate ferroptosis in traumatic brain injury. However, the role of Prok2/PKR signaling in SCI-induced ferroptosis and neurodegeneration is unclear. In this study, we examined the expression of Prok2/PKR signaling pathway components and the function of the Prok2/PKR signaling pathway in a rat model of contusion SCI. We found that the expression of Prok2 and PKRs decreased and was subsequently restored after SCI and that Prok2 and PKRs were localized in neurons in the anterior horn of the spinal cord. We also found that the expression levels of the ferroptosis-related proteins glutathione peroxidase 4 (GPX4) and acyl-CoA synthetase long-chain family member 4 (ACSL4) were altered after SCI, suggesting that neurons underwent ferroptosis. Furthermore, we demonstrated that upregulation of Prok2 by intraperitoneal injection of recombinant human Prok2 protein inhibited ferroptosis and reduced neurodegeneration after SCI and that this effect was mediated by PKR1 and PKR2, as silencing these receptors with small interfering RNA (siRNA) reversed recombinant Prok2-mediated ferroptosis inhibition. Our study is the first to reveal that Prok2/PKR signaling plays antiferroptotic and neuroprotective roles in SCI, making it a potential target for SCI treatment.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"570 ","pages":"Pages 185-194"},"PeriodicalIF":2.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effects of focused attention (mantra) meditation on mismatch negativity: Insights into sensory and cognitive processing using an intensity oddball paradigm

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-18 DOI: 10.1016/j.neuroscience.2025.02.017

Chandan Srivastava , Jamie A. O’Reilly , Rashmi Gupta

{"title":"Investigating the effects of focused attention (mantra) meditation on mismatch negativity: Insights into sensory and cognitive processing using an intensity oddball paradigm","authors":"Chandan Srivastava , Jamie A. O’Reilly , Rashmi Gupta","doi":"10.1016/j.neuroscience.2025.02.017","DOIUrl":"10.1016/j.neuroscience.2025.02.017","url":null,"abstract":"<div><div>Over the past fifty years, research has enhanced our understanding of meditation and its effects on cognition. Meditation is particularly promising due to its long-term (trait) effects, which persist outside meditation sessions. Advances in neuroimaging have enabled the study of these effects using neural markers such as mismatch negativity (MMN), which reflects the involuntary shift of attention to unexpected acoustic changes. This shift is modulated by attentional control, a key area where focused attention (FA) meditation training offers improvements. However, studies investigating the trait effects of FA meditation on MMN have produced mixed results, with previous research introducing confounds from short-term (state) effects that may influence trait-specific assessments. Furthermore, most research has focused on breath-based FA meditation, overlooking other prominent forms of FA meditation that might differentially modulate MMN, as per recent studies. The current study, therefore, examines mantra meditation, a widely practiced form of FA meditation, with an adequately powered sample to address the mixed findings in the literature. The study employs an intensity oddball paradigm instead of commonly used frequency oddball paradigms to assess whether MMN arises from higher-order cognitive processes or sensory adaptation. The findings reveal similar MMN amplitude in experts and novices, suggesting that MMN may be insensitive to meditation expertise or influenced by the enhanced attentional skills of novices. Additionally, a unidirectional polarity shift in event-related potential to deviant stimuli suggests that meditation effects on MMN are likely to be interpreted in the context of higher-order deviance detection mechanism.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"571 ","pages":"Pages 62-73"},"PeriodicalIF":2.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global prevalence of the mitochondrial MT-RNR1 A1555G variant in non-syndromic hearing loss: A systematic review and meta-analysis

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-17 DOI: 10.1016/j.neuroscience.2025.02.036

Baoai Han , Wenqing Wang , Han Wu , Juanjuan Hu , Liu Sun , Yun Zhu , Alan G. Cheng , Haiying Sun

引用次数: 0

Unscrambling the cellular and molecular threads of Neuroplasticity: Insights into Alzheimer’s disease pathogenesis

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-17 DOI: 10.1016/j.neuroscience.2025.02.037

Palak Kalra , Amarjot Kaur Grewal , Heena Khan , Thakur Gurjeet Singh

{"title":"Unscrambling the cellular and molecular threads of Neuroplasticity: Insights into Alzheimer’s disease pathogenesis","authors":"Palak Kalra , Amarjot Kaur Grewal , Heena Khan , Thakur Gurjeet Singh","doi":"10.1016/j.neuroscience.2025.02.037","DOIUrl":"10.1016/j.neuroscience.2025.02.037","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is predominantly the most recurring and devastating neurological condition among the elderly population, characterized by the accumulation of amyloid-β (Aβ) and phosphorylated tau proteins, and is accompanied by progressive decline of learning and memory. Due to its complex and multifactorial etiology, a wide variety of therapeutic interventions have been developed. Despite constant advancements in the field, effective treatments that ameliorate the severity of Alzheimer’s symptoms or cease their progression are still insufficient. Mounting evidence suggests that synaptic dysfunction could be an essential component of AD pathogenesis as synapse signaling is impaired in the aging brain, which contributes to synaptic decline. Therefore, improving neuroplasticity such as synaptic plasticity or neurogenesis could be a promising therapeutic approach for alleviating the effects of AD. This article reviews the cellular and molecular threads of neuroplasticity as well as targets that restore neuronal survival and plasticity to provide functional recoveries, including receptors, downstream signaling pathways, ion channels, transporters, enzymes, and neurotrophic factors.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"571 ","pages":"Pages 74-88"},"PeriodicalIF":2.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0