Miro1: A potential target for treating neurological disorders

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience Pub Date : 2025-05-20 DOI:10.1016/j.neuroscience.2025.05.019

Linghua Zeng , Juan Yang , Conghui Zhang , Junjie Zhu , Saichun Zhong , Xing Liu , Haiyu Xie , Lifeng Wang , Li Chen , Maolin Zhong , Fuzhou Hua , Weidong Liang

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引用次数: 0

Abstract

The Miro1 protein is a member of the mitochondrial Rho GTPase (Miro) protein family and plays a crucial role in regulating the dynamic processes of mitochondria and participating in cellular movement and mitochondrial transport. In the nervous system, it ensures adequate energy supply for normal neuronal function and synaptic transmission. Additionally, Miro1 actively participates in the regulation of mitochondrial quality control and stress responses within neurons. Its primary function is to sense intracellular stress signals to regulate mitochondrial movement and metabolism, thereby adapting to environmental changes. Multiple studies have indicated that the Miro1 protein is associated with the pathogenesis of various neurological disorders, such as Alzheimer’s Disease(AD), Parkinson’s Disease(PD), and Amyotrophic Lateral Sclerosis(ALS). This article reviews the mechanistic role of Miro1 in these diseases and summarizes the latest research on its involvement in neurological disorders. These efforts aim to provide unified treatment strategies for certain neurological disorders and explore the potential for treating complex neurological diseases.

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Miro1：治疗神经系统疾病的潜在靶点

mir1蛋白是线粒体Rho GTPase （Miro）蛋白家族的成员，在调节线粒体的动态过程，参与细胞运动和线粒体运输中起着至关重要的作用。在神经系统中，它为正常的神经元功能和突触传递保证充足的能量供应。此外，Miro1积极参与神经元内线粒体质量控制和应激反应的调节。其主要功能是感知细胞内应激信号，调节线粒体运动和代谢，从而适应环境变化。多项研究表明，Miro1蛋白与多种神经系统疾病的发病机制有关，如阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩侧索硬化症（ALS）。本文综述了Miro1在这些疾病中的作用机制，并对其参与神经系统疾病的最新研究进行了综述。这些努力旨在为某些神经系统疾病提供统一的治疗策略，并探索治疗复杂神经系统疾病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience 医学-神经科学

CiteScore

6.20

自引率

0.00%

发文量

394

审稿时长

52 days

期刊介绍： Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.