Neuroscience最新文献_第2页

"Current and emerging drug therapies in Alzheimer's disease: A pathophysiological Perspective".

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-09 DOI: 10.1016/j.neuroscience.2024.11.078

Aparajita Aparajita, Unnati Jain, Priyanka Srivastava

{"title":"\"Current and emerging drug therapies in Alzheimer's disease: A pathophysiological Perspective\".","authors":"Aparajita Aparajita, Unnati Jain, Priyanka Srivastava","doi":"10.1016/j.neuroscience.2024.11.078","DOIUrl":"10.1016/j.neuroscience.2024.11.078","url":null,"abstract":"The analytical and experimental investigation of several targets and biomarkers that help in explaining significant cognitive deficits, covering drug development and precision medicine aimed at different chronic neurodegenerative conditions such as Alzheimer's disease (AD), Parkinson's disease, synaptic dysfunction, brain damage from neuronal apoptosis, and other disease pathologies; this served as the foundation for all phase studies. The focus of current therapeutic approaches is on developing humanized antibodies, agonist and antagonist drugs, receptors, signaling molecules, major targeted drug-metabolizing enzymes, and other metabolites to treat neurodegeneration in the AD brain brought on by tau hyperphosphorylation, amyloid plagues, or other cholinergic effects. The five A's-amnesia, agnosia, aphasia, apraxia, and anomia-are the typical symptoms associated with AD. While the main goal of drug therapeutics studies is modified amino acids acting as pro-drugs, pharmacokinetics studies and trends in evaluating drug-drug interactions focus on interactions between drugs and antibodies, drugs and therapeutic biologics like metabolites, herbs, interleukin-based, and gene silencing mechanism-based. Studies on the biotransformation of xenobiotic compounds and the metabolism of exogenous and endogenous substances are conducted under Phase I, Phase II, and Phase III trials because the pivotal pharmacokinetic properties of drugs, such as absorption, distribution, metabolism, and excretion (ADME), aid in understanding variations in the crucial improvement of various target drugs. This review also highlights the developments in soon-to-be genetically created targeted medications that may serve as ground-breaking treatments for cholinergic illnesses in the brains of AD patients and other neurodegenerative conditions.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"499-518"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-29 DOI: 10.1016/j.neuroscience.2024.11.071

Olayemi Joseph Olajide, Ariel A Batallán Burrowes, Igor Ferraz da Silva, Andreas Bergdahl, C Andrew Chapman

{"title":"Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex.","authors":"Olayemi Joseph Olajide, Ariel A Batallán Burrowes, Igor Ferraz da Silva, Andreas Bergdahl, C Andrew Chapman","doi":"10.1016/j.neuroscience.2024.11.071","DOIUrl":"10.1016/j.neuroscience.2024.11.071","url":null,"abstract":"Reductions in circulating estrogens can contribute to cognitive decline, in part by impairing mitochondrial function within the hippocampal region. The entorhinal cortex provides the hippocampus with its main cortical inputs. To assess the impact of estrogen deficiency on mitochondrial respiration and synaptic proteins in the entorhinal cortex, female wildtype rats received either sham surgery, bilateral ovariectomy, or ovariectomy with implantation of a subdermal capsule to maintain low levels of circulating 17β-estradiol (E2). Mitochondrial respiration in the entorhinal cortex was not significantly affected two weeks following ovariectomy, but there was a reduction in oxygen consumption four weeks after ovariectomy that was prevented by E2 supplementation. The expression of mitochondrial membrane integrity element voltage-dependent anion channel protein (VDAC1) was also reduced four weeks after ovariectomy, suggesting that respiration was reduced due to a decline in mitochondrial density. Ovariectomy also increased mitochondrial and cytoplasmic cytochrome c and upregulated superoxide dismutase 2 (SOD2) both two and four weeks after ovariectomy, reflecting mitochondrial electron leakage and oxidative redox imbalance. Further, the ovariectomy-induced changes in mitochondrial proteins were associated with reductions in postsynaptic density protein 95 (PSD95) and the presynaptic protein synaptophysin. There were no changes in mitochondrial or synaptic proteins in ovariectomized animals that received E2 supplementation. Our findings indicate that reductions in circulating 17β-estradiol induced by ovariectomy disrupt mitochondrial functions in the entorhinal cortex, and suggest that a resulting increase in oxidative stress contributes to the degradation in synaptic proteins that may affect cognitive functions mediated by the hippocampal region.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"479-486"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellar activity and functional connectivity in subacute subcortical aphasia: Association with language recovery.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-01 DOI: 10.1016/j.neuroscience.2024.11.077

Hailong Li, Xiaohui Xie

{"title":"Cerebellar activity and functional connectivity in subacute subcortical aphasia: Association with language recovery.","authors":"Hailong Li, Xiaohui Xie","doi":"10.1016/j.neuroscience.2024.11.077","DOIUrl":"10.1016/j.neuroscience.2024.11.077","url":null,"abstract":"Loss of language function (aphasia) is a common complication after stroke, and post-stroke recovery remains highly unpredictable due to the absence of reliable neurobiomarkers. Growing evidence points to involvement of the cerebellum in language processing; however, it is unclear if abnormal cerebellar activity and altered functional connectivity (FC) to language-related regions of cerebral cortex are underlying neural mechanisms for subcortical aphasia. In this longitudinal observational study, we used resting-state functional magnetic resonance imaging to examine potential abnormalities in spontaneous cerebellar activity and resting-state (rs)FC with language networks among post-stroke patients with subacute subcortical aphasia (n = 19) compared to healthy controls (HCs, n = 18). In addition, correlations between rsFC variables and language performance metrics were examined at post-stroke baseline and at follow-up. Compared to HCs, patients with subacute subcortical aphasia exhibited significantly reduced fractional amplitude of low frequency fluctuations, a measure of spontaneous activity, in the right cerebellar Crus II (rCrus II) region and reduced rsFC between rCrus II and left inferior frontal gyrus (LIFG), left angular gyrus (LAG), and left middle temporal gyrus (LMTG). Both rCrus II-LAG and rCrus II-LMTG rsFC values were positively correlated with Aphasia Battery of Chinese scores at baseline. Baseline rCrus II-LIFG rsFC was also positively correlated with spontaneous speech and naming scores at follow-up. A stronger baseline rCrus II-LIFG rsFC predicted superior recovery of language function post-stroke. We conclude that the right cerebellum may be an effective therapeutic target for subcortical aphasia.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"320-326"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical application of respiratory-gated auricular vagal afferent nerve stimulation.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-28 DOI: 10.1016/j.neuroscience.2024.11.065

Zhiyuan Han, Cuicui Zhang, Keling Cheng, Yunfang Chen, Zhiqin Tang, Lewen Chen, Jun Ni, Zhiyong Wang

{"title":"Clinical application of respiratory-gated auricular vagal afferent nerve stimulation.","authors":"Zhiyuan Han, Cuicui Zhang, Keling Cheng, Yunfang Chen, Zhiqin Tang, Lewen Chen, Jun Ni, Zhiyong Wang","doi":"10.1016/j.neuroscience.2024.11.065","DOIUrl":"10.1016/j.neuroscience.2024.11.065","url":null,"abstract":"Vagus nerve stimulation (VNS) has garnered significant attention as a promising bioelectronic therapy. In recent years, respiratory-gated auricular vagal afferent nerve stimulation (RAVANS), a novel non-invasive vagus nerve stimulation technique, has emerged. RAVANS integrates respiration with transcutaneous auricular vagus nerve stimulation (taVNS) and shares a similar mechanism of action to traditional VNS. Similar to conventional Vagus Nerve Stimulation (VNS), RAVANS may mitigate brain injury through three primary pathways: reducing neuronal apoptosis, modulating neurotransmitter release, and influencing inflammatory factor pathways. In this paper, we emphasize how RAVANS enhances the activation of nucleus of the solitary tract （NTS）and the locus coeruleus by regulating the monoaminergic and GABA systems through respiratory control. Additionally, it leverages the beneficial effects of respiration on the central nervous system. In this review, we delineate the potential mechanisms of action of RAVANS, provide a comprehensive overview of its clinical applications in chronic low back pain, migraine, depression, hypertension, and cognitive disorders. Furthermore, we offer future perspectives on optimizing the parameters of RAVANS and its application in post-stroke dysphagia. This will pave the way for new avenues in RAVANS research.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"117-123"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in cerebral spontaneous neural activity correlate with gene-specific transcriptional signatures in primary angle-closure glaucoma.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-07 DOI: 10.1016/j.neuroscience.2024.12.012

Xiao-Tong Li, Lei Chen, Xin-Miao Wang, Chun-Cheng Zheng, Xin Huang

{"title":"Differences in cerebral spontaneous neural activity correlate with gene-specific transcriptional signatures in primary angle-closure glaucoma.","authors":"Xiao-Tong Li, Lei Chen, Xin-Miao Wang, Chun-Cheng Zheng, Xin Huang","doi":"10.1016/j.neuroscience.2024.12.012","DOIUrl":"10.1016/j.neuroscience.2024.12.012","url":null,"abstract":"Aims: This study was aimed to investigate frequency-specific LFO changes and their correlation with gene pathways in PACG using transcriptome-neuroimaging analysis.Methods: Resting-state fMRI (Rs-fMRI) data were acquired from individuals with PACG and healthy controls for evaluating the amplitude of low-frequency oscillations (ALFF) across different frequency bands such as the full band, slow-4 band, and slow-5 band. Transcriptome analysis integrated information from the Allen Human Brain Atlas (AHBA) through gene set enrichment analysis, protein-protein interaction network construction, and specific expression analysis, aiming to clarify the link between ALFF patterns and gene expression profiles in PACG. Statistical analyses, including one-sample t-tests and two-sample t-tests, were used to assess ALFF differences between groups, while partial least squares (PLS) regression was applied to explore the associations between ALFF and transcriptome data.Results: This study identifies significant variations in ALFF values in PACG patients, observed consistently across multiple frequency bands, including slow-4 and slow-5. Enrichment analysis indicates that these genes are primarily involved in cellular components such as the cytosol and cytoplasm, molecular functions like protein binding, and key pathways, including metabolic and circadian rhythms, epithelial signaling in Helicobacter pylori infection, and glutathione metabolism. Protein-protein interaction (PPI) analysis further underscores the role of PACG-related genes in forming a functional network, highlighting hub genes critical for various biological processes.Conclusion: This study establishes a connection between the molecular mechanisms of PACG and alterations in brain function and gene expression, providing valuable perspectives on the fundamental processes impacting low-frequency oscillations in PACG.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"399-419"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-15 DOI: 10.1016/j.neuroscience.2024.12.024

Srikanth Yadava, Dontiboina Harikrishna Reddy, Venkata Prasuja Nakka, Vinjavarapu Lakshmi Anusha, Naresh Dumala, Matte Kasi Viswanadh, Guntupalli Chakravarthi, Buchi N Nalluri, Kakarla Ramakrishna

{"title":"Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms.","authors":"Srikanth Yadava, Dontiboina Harikrishna Reddy, Venkata Prasuja Nakka, Vinjavarapu Lakshmi Anusha, Naresh Dumala, Matte Kasi Viswanadh, Guntupalli Chakravarthi, Buchi N Nalluri, Kakarla Ramakrishna","doi":"10.1016/j.neuroscience.2024.12.024","DOIUrl":"10.1016/j.neuroscience.2024.12.024","url":null,"abstract":"Stroke is a serious condition often resulting in mortality or long-term disability, causing cognitive, memory, and motor impairments. A reduction in cerebral blood flow below critical levels defines the ischemic core and penumbra: the core undergoes irreversible damage, while the penumbra remains viable but functionally impaired. This functional impairment activates complex cell signaling pathways that determine cell survival or death, making the penumbra a key target for therapeutic interventions to prevent further damage. The Wnt/β-catenin (WβC) signaling pathway has emerged as a potential neuroprotective mechanism, promoting neurogenesis, angiogenesis, neuronal connectivity, and maintaining blood-brain barrier integrity after stroke. Activation of the WβC pathway also mitigates oxidative stress, inflammation, and apoptosis in ischemic regions, enhancing its neuroprotective effects. However, the overexpression of GSK3β and DKK1, or the presence of their agonists, can counteract these benefits. This review explores the therapeutic potential of WβC signaling, highlighting the effects of pharmacological modulation through antagonists, agonists, synthetic chemicals, natural products, stem cells, and macromolecules in preclinical models of ischemic stroke. While preclinical evidence supports the benefits of WβC activation, its role in human stroke requires further investigation. Additionally, the review discusses the potential adverse effects of prolonged WβC activation and suggests strategies to mitigate them. Overall, WβC signaling holds promise as a therapeutic target, offering insights into stroke pathophysiology and informing the development of novel treatment strategies.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"527-547"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pigs as a translational animal model for the study of peak alpha frequency.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-16 DOI: 10.1016/j.neuroscience.2024.12.022

Daniel Skak Mazhari-Jensen, Winnie Jensen, Taha Al Muhammadee Janjua, Suzan Meijs, Thomas Gomes Nørgaard Dos Santos Nielsen, Felipe Rettore Andreis

{"title":"Pigs as a translational animal model for the study of peak alpha frequency.","authors":"Daniel Skak Mazhari-Jensen, Winnie Jensen, Taha Al Muhammadee Janjua, Suzan Meijs, Thomas Gomes Nørgaard Dos Santos Nielsen, Felipe Rettore Andreis","doi":"10.1016/j.neuroscience.2024.12.022","DOIUrl":"10.1016/j.neuroscience.2024.12.022","url":null,"abstract":"The most characteristic feature of the human electroencephalogram is the peak alpha frequency (PAF). While PAF has been proposed as a biomarker in several diseases and disorders, the disease mechanisms modulating PAF, as well as its physiological substrates, remain elusive. This has partly been due to challenges related to experimental manipulation and invasive procedures in human neuroscience, as well as the scarcity of animal models where PAF is consistently present in resting-state. With the potential inclusion of PAF in clinical screening and decision-making, advancing the mechanistic understanding of PAF is warranted. In this paper, we propose the female Danish Landrace pig as a suitable animal model to probe the mechanisms of PAF and its feature as a biomarker. We show that somatosensory alpha oscillations are present in anesthetized pigs using electrocorticography and intracortical electrodes located at the sensorimotor cortex. This was evident when looking at the time-domain as well as the spectral morphology of spontaneous recordings. We applied the FOOOF-algorithm to extract the spectral characteristics and implemented a robustness threshold for any periodic component. Using this conservative threshold, PAF was present in 18/20 pigs with a normal distribution of the peak frequency between 8-12 Hz, producing similar findings to human recordings. We show that PAF was present in 69.6 % of epochs of approximately six-minute-long resting-state recordings. In sum, we propose that the pig is a suitable candidate for investigating the neural mechanisms of PAF as a biomarker for disease and disorders such as pain, neuropsychiatric disorders, and response to pharmacotherapy.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"567-576"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial near-infrared light promotes remyelination through AKT1/mTOR pathway to ameliorate postoperative neurocognitive disorder in aged mice.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-07 DOI: 10.1016/j.neuroscience.2024.12.007

Jiawei Chen, Yuqing He, Junying Zhong, Yanni Fu, Shangyan Yuan, Longjie Hou, Xiaojun Zhang, Fanqing Meng, Wei-Jye Lin, Fengtao Ji, Zhi Wang

{"title":"Transcranial near-infrared light promotes remyelination through AKT1/mTOR pathway to ameliorate postoperative neurocognitive disorder in aged mice.","authors":"Jiawei Chen, Yuqing He, Junying Zhong, Yanni Fu, Shangyan Yuan, Longjie Hou, Xiaojun Zhang, Fanqing Meng, Wei-Jye Lin, Fengtao Ji, Zhi Wang","doi":"10.1016/j.neuroscience.2024.12.007","DOIUrl":"10.1016/j.neuroscience.2024.12.007","url":null,"abstract":"Postoperative neurocognitive disorder (PND) is a prevalent complication following surgery and anesthesia, characterized by progressive cognitive decline. The precise etiology of PND remains unknown, and effective targeted therapeutic strategies are lacking. Transcranial near-infrared light (tNIRL) has shown potential benefits for cognitive dysfunction diseases, but its effect on PND remains unclear. Our previous research indicated a close association between demyelination and PND. In other central nervous system (CNS) disorders, tNIRL has been demonstrated to facilitate remyelination in response to demyelination. In this study, we established the PND model in 18-month-old male C57BL/6 mice using isoflurane anesthesia combined with left common carotid artery exposure. Following surgery, PND-aged mice were subjected to daily 2.5-minute tNIRL treatment at 810 nm for three consecutive days. Subsequently, we observed that tNIRL significantly improved cognitive performance and reduced inflammatory cytokine levels in the hippocampus of PND mice. Furthermore, tNIRL increased the expression of oligodendrocyte transcription factor 2 (OLIG2) and myelin basic protein (MBP), promoting remyelination while enhancing synaptic function-associated proteins such as synaptophysin (SYP) and postsynaptic density protein 95 (PSD95). Further investigation revealed that tNIRL may activate the AKT1/mTOR pathway to facilitate remyelination in PND mice. These findings indicate that tNIRL is a novel non-invasive therapeutic approach for treating PND.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"358-368"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional connectivity induced by social cognition task predict individual differences in loneliness. 社会认知任务诱导的功能连接可预测孤独感的个体差异。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-12 DOI: 10.1016/j.neuroscience.2024.12.001

Li Geng, Jie Meng, Qiuyang Feng, Yu Li, Jiang Qiu

{"title":"Functional connectivity induced by social cognition task predict individual differences in loneliness.","authors":"Li Geng, Jie Meng, Qiuyang Feng, Yu Li, Jiang Qiu","doi":"10.1016/j.neuroscience.2024.12.001","DOIUrl":"10.1016/j.neuroscience.2024.12.001","url":null,"abstract":"Loneliness is intricately connected to social cognition, yet the precise brain mechanisms that underscore their relationship need further exploration. The present study employed a theory of mind processing task that engaged participants in assessing the trajectories of geometric shapes while undergoing fMRI scans. The comprehensive data pool encompassed loneliness assessments and brain imaging data from a cohort of 157 participants. Utilizing a machine learning approach, task-induced functional connectivity data was used to forecast individuals' loneliness scores. The findings unveil that specific patterns of task-induced alterations in brain functional connectivity hold a remarkable capability to anticipate loneliness scores. Further dissection of the data disclosed pivotal nodes, including the prefrontal cortex, temporoparietal junction, and amygdala, among other cerebral regions. Furthermore, functional connectivity among the social network, the default mode network, and somatomotor networks emerged as crucial factors in prediction. Brain regions contributed strongly in prediction are involved in a variety of social cognitive processes, including intention inference, empathy, and information integration. The results illuminate the association between brain functional connectivity induced by social cognition and loneliness, which enhance the comprehensive understanding of this complex emotional state and may have implications for its diagnosis and intervention.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"431-439"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-30 DOI: 10.1016/j.neuroscience.2024.11.070

Nitu L Wankhede, Mayur B Kale, Ashishkumar Kyada, Rekha M M, Kamlesh Chaudhary, K Satyam Naidu, Sandip Rahangdale, Prajwali V Shende, Brijesh G Taksande, Mohammad Khalid, Monica Gulati, Milind J Umekar, Mohammad Fareed, Spandana Rajendra Kopalli, Sushruta Koppula

{"title":"Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders.","authors":"Nitu L Wankhede, Mayur B Kale, Ashishkumar Kyada, Rekha M M, Kamlesh Chaudhary, K Satyam Naidu, Sandip Rahangdale, Prajwali V Shende, Brijesh G Taksande, Mohammad Khalid, Monica Gulati, Milind J Umekar, Mohammad Fareed, Spandana Rajendra Kopalli, Sushruta Koppula","doi":"10.1016/j.neuroscience.2024.11.070","DOIUrl":"10.1016/j.neuroscience.2024.11.070","url":null,"abstract":"Sleep deprivation is a prevalent issue in contemporary society, with significant ramifications for both physical and mental well-being. Emerging scientific evidence illuminates its intricate interplay with the gut-brain axis, a vital determinant of neurological function. Disruptions in sleep patterns disturb the delicate equilibrium of the gut microbiota, resulting in dysbiosis characterized by alterations in microbial composition and function. This dysbiosis contributes to the exacerbation of neurological disorders such as depression, anxiety, and cognitive decline through multifaceted mechanisms, including heightened neuroinflammation, disturbances in neurotransmitter signalling, and compromised integrity of the gut barrier. In response to these challenges, there is a burgeoning interest in therapeutic interventions aimed at restoring gut microbial balance and alleviating neurological symptoms precipitated by sleep deprivation. Probiotics, dietary modifications, and behavioural strategies represent promising avenues for modulating the gut microbiota and mitigating the adverse effects of sleep disturbances on neurological health. Moreover, the advent of personalized interventions guided by advanced omics technologies holds considerable potential for tailoring treatments to individualized needs and optimizing therapeutic outcomes. Interdisciplinary collaboration and concerted research efforts are imperative for elucidating the underlying mechanisms linking sleep, gut microbiota, and neurological function. Longitudinal studies, translational research endeavours, and advancements in technology are pivotal for unravelling the complex interplay between these intricate systems.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"99-116"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0