Neuroscience最新文献

{"title":"Choroid plexus enlargement correlates with cognitive impairment and brain atrophy in patients with temporal lobe epilepsy.","authors":"Ran Li, Kehong Zeng, Jinshuai Liu, Zifan Yang, Yu Wang","doi":"10.1016/j.neuroscience.2025.09.046","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.09.046","url":null,"abstract":"<p><p>As a component of the glymphatic system, the choroid plexus (CP) plays a role in the clearance of metabolic waste and its enlargement is associated with chronic inflammation and glymphatic system dysfunction. We investigated the relationship between choroid plexus volume and cognitive impairment in patients with temporal lobe epilepsy (TLE). Brain MRI, clinical evaluation, and cognition assessment were obtained from patients with TLE and healthy controls. Automatic segmentation was performed to acquire brain regions and CP volumes. The relationship between CP volume and Montreal Cognitive Assessment (MoCA) score and gray matter volume was analyzed using multivariate linear regression. The mediating effects of crucial brain regions on the association between CP volume and MoCA score in the TLE group were examined. Random forests were used to identify predictors of cognitive impairment. Compared to the HC group, patients with TLE exhibited significantly larger CP volume. CP volume enlargement correlated with low MoCA score and decreased gray matter volume. Hippocampal and thalamic volumes had a substantial mediating effect on the association of CP volume and cognitive function. Education level and volume of hippocampus, CP and thalamus were selected as the most relevant factors for diagnosing cognitive impairment in patients with TLE. CP volume could be a non-invasive and reliable neuroimaging marker for the diagnosis of cognitive impairment in patients with temporal lobe epilepsy.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ibogaine alters the firing rate and afterhyperpolarization in mouse ventral tegmental area I_h-negative neurons in a sex-dependent manner.","authors":"Jannik Nicklas Eliasen, Amir Rezagholizadeh, Helene Påbøl Jacobsen, Uffe Kristiansen, Kristi A Kohlmeier","doi":"10.1016/j.neuroscience.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.10.001","url":null,"abstract":"<p><p>Depression and substance use disorder affect millions world-wide, and risk factors include sex. Conventional pharmacotherapies show at best a 50 % success rate. Psychedelics exhibit both anti-addictive and anti-depressive properties. One of these, ibogaine, a root bark sourced alkaloid, interacts with receptors implicated in anti-depressive and anti-addictive effects with affinities in the micromolar range. However, cellular actions underlying therapeutic properties are not well understood. In this study, for the first time, we evaluated the cellular effects of 100 µM ibogaine on putative GABAergic neurons of the ventral tegmental area (VTA), as activity of neurons in this nucleus, which includes dopamine neurons, modulates emotion and motivated behavior. Neurons from male (n = 14) and female mice (n = 16) were putatively identified as GABAergic based on lack of I_h-current. While we detected no ibogaine induced effects on membrane currents, membrane potential, I-V relationship, rheobase or spontaneous excitatory postsynaptic currents (sEPSCs) in either sex, rises in intracellular calcium were induced in males and females. Further, ibogaine decreased the action potential firing rate in males, but not in females, whereas altered afterhyperpolarization kinetics were noted in females, but not males. Interestingly, at baseline, male I_h-negative VTA neurons fired action potentials at a significantly higher frequency than females, however, membrane currents, I-V relationship, membrane potential, rheobase, and sEPSCs did not differ between sexes. Our data suggest that sex-based firing differences exist in a subpopulation of VTA neurons and further, ibogaine induces changes in neuronal signaling in this population that differ between males and females, which could contribute to therapeutic actions.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of beneficial effect and mechanism of propofol on TNF-α-induced p-Tau increase in HT22 hippocampal neurons","authors":"Shuai Gao ,&nbsp;Yifei Wang ,&nbsp;Zhihong Xu ,&nbsp;Minmin Zhu ,&nbsp;Zhipeng Meng ,&nbsp;Guanghui An ,&nbsp;Jiawei Chen","doi":"10.1016/j.neuroscience.2025.09.048","DOIUrl":"10.1016/j.neuroscience.2025.09.048","url":null,"abstract":"<div><h3>Background</h3><div>Tau protein is a soluble microtubule-binding protein expressed in neurons. Abnormal post-translational modifications, such as hyperphosphorylation, are closely related to central nervous system inflammation and may lead to neuronal damage. Propofol has been shown to exert neuroprotective effects. In this study, we investigated the effects of propofol on TNF-α-induced p-Tau increase in hippocampal neurons and explored the underlying mechanisms.</div></div><div><h3>Methods</h3><div>HT22 hippocampal neurons were pretreated with propofol, and then stimulated with TNF-α. Cell viability was measured by cell counting kit-8 (CCK-8). The expression and phosphorylation of Tau, AMPK, AKT and the expression of SIRT3 were detected by Western blot. Mitophagy was detected through the mitophagy detection kit and confocal imaging of LC3B localization.</div></div><div><h3>Results</h3><div>TNF-α enhanced Tau phosphorylation in a time- and dose-dependent manner, and significant effects were observed at 10 ng/mL for 2 h. Pretreatment with 25 μM propofol for 1 h effectively reduced TNF-α-induced Tau phosphorylation. TNF-α activated the phosphorylation of AMPK and AKT, which was attenuated by propofol pretreatment and by AMPK inhibitor (Compound C) or AKT inhibitor (MK2206). Meanwhile, TNF-α promoted mitophagy and upregulated the expression of SIRT3, which was inhibited by propofol and by SIRT3 inhibitor (3-TYP).</div></div><div><h3>Conclusions</h3><div>Propofol may attenuate TNF-α-induced p-Tau expression in HT22 cells through modulation of the AMPK/AKT signaling pathway, and may inhibit TNF-α-enhanced mitophagy by affecting the AMPK/SIRT3 signaling pathway.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 81-89"},"PeriodicalIF":2.8,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Smarce1 subunit of the BAF complex performs distinct, stage-specific functions during zebrafish retinal development","authors":"Laura Ramírez ,&nbsp;Denhí Schnabel ,&nbsp;Flavio R. Zolessi ,&nbsp;Hilda Lomelí","doi":"10.1016/j.neuroscience.2025.09.045","DOIUrl":"10.1016/j.neuroscience.2025.09.045","url":null,"abstract":"<div><div>In the developing vertebrate retina, progenitor cells proliferate and differentiate into specialized neurons with remarkable spatial and temporal precision. This process is coordinated by multiple interactions between the genome and the epigenome. Chromatin remodeling plays an important role in the regulation of retinal cell type-specific transcriptional programs. Vertebrate switch/sucrose non-fermentable (SWI/SNF) complexes, also known as Brg1/Brg-associated factors (BAF complexes)<!--> <!-->are multi-subunit, ATP-dependent chromatin-remodeling complexes assembled from homologous subunit families. The ATPase subunit of these complexes, Smarca4 (also known as Brg1), has been implicated in retinal development. Among the other core subunits, one that is incorporated early into the BAF complex is Smarce1 (also known as Baf57), which is present in all BAF assemblies. Notably, recent findings show that this protein acts as a mitotic bookmark in mouse embryonic stem cells to preserve cell identity during cell division.</div><div>In this work, we examined the retinal phenotype in <em>smarce1</em> zebrafish mutants and compared it with that in <em>smarca4</em> mouse and zebrafish mutants. The <em>smarce1</em> gene was differentially expressed in progenitors and neurons during development. We found that Smarce1 deficiency reduces the cell proliferation of retinal progenitors and produces a severe cell death. Although all classes of retinal neurons are specified in <em>smarce1</em> embryos, normal lamination of retinal cells is altered and differentiation of photoreceptors is deficient.</div><div>Given that not all of these phenotypes are observed in the zebrafish <em>smarca4/Brg1</em>-mutant, we propose that a differential configuration of the BAF complex in the retina contributes to distinct functions during retinogenesis.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 146-156"},"PeriodicalIF":2.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Origanum majorana tea on oxidative stress biomarkers in Parkinson’s disease: a randomized placebo-controlled pilot study","authors":"Chbili Chahra ,&nbsp;Mrad Sawssen ,&nbsp;Hassine Anis ,&nbsp;Naija Salma ,&nbsp;Nouira Manel ,&nbsp;Ben Amor Sana ,&nbsp;Ben Fredj Maha","doi":"10.1016/j.neuroscience.2025.09.047","DOIUrl":"10.1016/j.neuroscience.2025.09.047","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate whether the consumption of <em>Origanum majorana</em> tea (<em>Om</em>t) affects oxidative stress biomarkers, potentially alleviating symptoms or slowing disease progression in volunteers with idiopathic Parkinson’s disease (PD).</div></div><div><h3>Methods</h3><div>A randomized, double-blind, placebo-controlled trial (PACTR202205801626909) was conducted, including healthy volunteers. Participants were randomly assigned to receive either <em>Omt</em> (experimental group, n = 30) or a placebo tea (control group, n = 25) once daily for 30 consecutive days. Blood samples were collected from each volunteer at two time points: one day before the study (Day₁) and one day after its conclusion (Day₃₁). Oxidative stress biomarkers, including superoxide dismutase (SOD), catalase, uric acid, and carbonylated proteins, were analyzed.</div></div><div><h3>Results</h3><div>The two groups were comparable in terms of demographic and clinical characteristics. In the experimental group, Day₃₁ measurements showed a significant increase in SOD (19.28 U/mg) and catalase (130.1 µmol/L) compared to Day₁, while carbonylated protein levels decreased by 0.18 nmol/mg protein. Additionally, on Day₃₁, the experimental group exhibited significantly higher SOD and catalase levels and lower carbonylated protein levels than the control group. Significant interaction effects between time (Day₁ vs. Day₃₁) and group (control vs. experimental) were observed for SOD, catalase, and carbonylated proteins.</div></div><div><h3>Conclusion</h3><div><em>Origanum majorana</em> infusion may enhance or regulate antioxidant status and reduce oxidative damage in patients with PD. Further studies are warranted to explore its potential therapeutic benefits.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 139-145"},"PeriodicalIF":2.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of screen time and physical activity with TMS-based measures of motor cortical excitability in adolescents","authors":"Hannamari Skog ,&nbsp;Sara Määttä ,&nbsp;Laura Säisänen ,&nbsp;Timo A. Lakka ,&nbsp;Eero A. Haapala","doi":"10.1016/j.neuroscience.2025.09.054","DOIUrl":"10.1016/j.neuroscience.2025.09.054","url":null,"abstract":"<div><div>Adolescence represents a crucial and sensitive period for brain neurobiological development. Screen time and physical activity may impact brain development, but evidence on their associations with cortical inhibition and excitability remains limited. We investigated cross-sectional associations of self-reported screen time and physical activity with cortical inhibition and excitability in adolescents. Altogether, 45 Finnish adolescents (20 males) aged 16–19 years underwent<!--> <!-->navigated transcranial magnetic stimulation examination. Corticospinal excitability and corticospinal and intracortical inhibition were measured using resting motor thresholds, long-interval intracortical inhibition, silent period duration, and silent period thresholds. Questionnaires were used to assess screen time (smart device time, computer time, time spent watching television and videos) and physical activity (organized sports in sports clubs, supervised exercise other than sports, unsupervised physical activity). Longer total screen time was associated with weaker corticospinal inhibition. Longer computer use was associated with stronger motor cortex excitability and stronger intracortical inhibition, whereas longer television and video viewing times were associated with weaker intracortical and corticospinal inhibition. Higher levels of organized sports were associated with stronger motor cortex excitability, whereas higher levels of unsupervised physical activity were associated with weaker corticospinal excitability and higher inhibitory thresholds. In conclusion, passive screen time was linked to weaker intracortical and corticospinal inhibition, whereas organized physical activity was associated with stronger motor cortex excitability. These findings highlight the differential associations of active and passive screen time as well as structured and unstructured physical activity with cortical excitability and inhibition, suggesting their distinct roles in neurodevelopment during adolescence.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 98-107"},"PeriodicalIF":2.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of neurotrophins in sensory processing in autism","authors":"Maria Suprunowicz,&nbsp;Agata Wińska,&nbsp;Aleksandra Julia Oracz,&nbsp;Stefan Modzelewski,&nbsp;Beata Konarzewska,&nbsp;Napoleon Waszkiewicz","doi":"10.1016/j.neuroscience.2025.09.051","DOIUrl":"10.1016/j.neuroscience.2025.09.051","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by a wide range of symptoms, including altered sensory processing. Impaired perception and interpretation of sensory stimuli may result from abnormal neuroplasticity and disruptions in neurotrophin signaling. These phenomena play a crucial role in neuronal development and function. Elevated serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) have been reported in individuals with ASD, while concentrations of neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) appear unchanged. However, extant research has not yet examined the relationship between neurotrophin levels and sensory integration deficits, thus indicating a significant gap in the current body of knowledge. The heterogeneity of ASD, encompassing a broad spectrum of symptoms and neuroanatomical alterations, complicates the search for universal biomarkers. Consequently, an analysis of neurotrophin concentrations in relation to specific sensory disturbances and their severity may offer valuable insights. Modulation of neurotrophin signaling has emerged as a promising therapeutic avenue; however, its effectiveness in ASD remains unclear. A paucity of studies has evaluated the potential of neurotrophins as biomarkers for diagnosis or treatment monitoring. Nevertheless, recent advances in biotechnology—including gene therapy, pharmacological agents that enhance neurotrophin release, and non-invasive brain stimulation—offer the prospect of more effective and personalized interventions for ASD. Despite the nascent stage of research in this domain, these approaches hold considerable promise for future autism treatment.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 90-97"},"PeriodicalIF":2.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A role for the TMEM132D gene in psychiatric disorders revealed by a neuroscience class assignment","authors":"Reem Hjoj ,&nbsp;Yuri Bozzi","doi":"10.1016/j.neuroscience.2025.09.055","DOIUrl":"10.1016/j.neuroscience.2025.09.055","url":null,"abstract":"<div><div>As part of the “Brain Development and Disease” course in the Master’s program in Cognitive Sciences at the University of Trento (Italy), students are asked to analyze the expression of a gene whose dysfunction is linked to a disorder of the nervous system. Their final task is to prepare a research article discussing collected data in the context of the disorder. In one such project, we examined publicly available datasets to study TMEM132D (also called MOLT, Mature OLigodendrocyte Transmembrane protein) mRNA expression in psychiatric disorders-related brain regions across development in mice and humans.</div><div>Findings revealed that TMEM132D is developmentally regulated, with elevated expression in frontal and limbic regions during postnatal stages in both species, pointing to a conserved evolutionary function. In the human brain, the gene showed a biphasic expression pattern, peaking in infancy and again in emerging adulthood — two periods marked by heightened plasticity. These results, consistent with prior research, suggest that TMEM132D may influence the maturation of neural circuits, possibly through mechanisms such as myelination or actin-related processes.</div><div>In adult brains, expression levels of TMEM132D appeared to gradually decline with age. This trend further supports the potential role of TMEM132D in shaping neural connectivity during earlier stages of life, when structural and functional remodeling is most active.</div><div>Altogether, the study highlights TMEM132D as a candidate gene in the neurodevelopmental basis of psychiatric disorders. It also demonstrates the educational value of involving students in authentic data collection and analysis: such classroom projects not only enhance learning but can also generate original, hypothesis-driven insights worthy of further scientific exploration.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 23-26"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C9orf72 related poly-Glycine-Alanine promotes tau phosphorylation and cell death via ERK1/2 interaction in cellular models","authors":"Jiahan Zhuang ,&nbsp;Zixuan Zhang ,&nbsp;Hongfu Jin ,&nbsp;Ji Qi ,&nbsp;Yuanyuan Chen ,&nbsp;Lin Ding ,&nbsp;Chenglai Fu ,&nbsp;Weiwei Cheng","doi":"10.1016/j.neuroscience.2025.09.053","DOIUrl":"10.1016/j.neuroscience.2025.09.053","url":null,"abstract":"<div><div>Frontotemporal lobar degeneration (FTLD), particularly cases linked to the C9ORF72 GGGGCC repeat expansion (r(G4C2)exp), is closely associated with TAR DNA-binding protein 43 (TDP-43) pathology but also exhibits concurrent tau pathology characterized by hyperphosphorylation and neurofibrillary tangles (NFTs). Despite evidence suggesting heightened tau pathology severity in C9ORF72 mutation carriers compared to other FTLD subtypes, the mechanistic interplay between r(G4C2)exp and tau dysregulation remains poorly understood. Using a cellular model, we demonstrated that (GA)₅₀ causes significant neuronal cell death. We found that (GA)₅₀ was shown to specifically bind to extracellular-regulated kinase 1/2 (ERK1/2) protein, leading to its hyperphosphorylation. This activation of ERK1/2 was associated with increased tau phosphorylation and aggregation. Importantly, inhibiting ERK1/2 activity with U0126 significantly reduced tau phosphorylation, aggregation, and cell death in cells overexpressing (GA)₅₀. These <em>in vitro</em> findings suggest that (GA)₅₀-driven ERK1/2 hyperphosphorylation may represent potential driver of tau pathology in C9ORF72-related FTLD, highlighting the ERK1/2 signaling or its interaction with poly-glycine-alanine (GA) as a potential therapeutic target.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"587 ","pages":"Pages 123-130"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of the prognostic value and immune infiltration of Uridine Monophosphate Synthetase (UMPS) in Pan-Glioma.","authors":"Dong He, Xiaokun Jiang, Jinfeng Ma, Jinyan Chen, Yongfei Zhang, Xixi Dou, Qingwen Jia, Qian Liu, Ping Xie, Zhen Zhang","doi":"10.1016/j.neuroscience.2025.09.056","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.09.056","url":null,"abstract":"<p><p>Uridine Monophosphate Synthetase (UMPS) is a pivotal enzyme in nucleotide metabolism, playing a crucial role in the synthesis of purine and thymidine nucleotides. These nucleotides are essential for DNA and RNA synthesis, thereby impacting cell growth, proliferation, and immune function. In glioblastoma (GBM), a highly malignant primary brain tumor, nucleotide metabolism is abnormally active, and UMPS expression is significantly upregulated. This study aimed to investigate the expression patterns, prognostic potential, and functional roles of UMPS in GBM, as well as its correlation with immune infiltration. Our findings revealed that UMPS expression is elevated in GBM compared to normal tissues and correlates positively with WHO grades of central nervous system tumors. High UMPS expression was associated with shorter overall survival, disease-specific survival, and progression-free interval. Furthermore, This study is the first to reveal that UMPS promotes an immunosuppressive microenvironment in glioma through dual regulation of tumor cell nucleotide metabolism and immune suppression. This establishes a novel link between a metabolic enzyme and immune evasion, providing a new perspective for targeting UMPS in metabolism-immunity combination therapy. Its novelty lies in breaking through the traditional framework of metabolic enzyme research by reframing UMPS as a key node connecting core tumor metabolism to the remodeling of the immune microenvironment. Our study highlights UMPS as a potential therapeutic target in GBM, where modulating its activity or expression could disrupt nucleotide metabolism, inhibit tumor growth, and enhance immune responses.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}