Neuroscience最新文献_第2页

Effect of electro-acupuncture on motor dysfunction in middle cerebral artery occlusion/reperfusion rats though cortex-striatum somatostatin neural circuit 电针通过皮层-纹状体生长抑素神经回路对大脑中动脉闭塞/再灌注大鼠运动功能障碍的影响。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-09 DOI: 10.1016/j.neuroscience.2025.09.012

Yi Zheng , Wenju Wang , Sijia Xia , Tao Jiang , Rui Li , Minguang Yang , Weilin Liu , Lidian Chen , Jing Tao

{"title":"Effect of electro-acupuncture on motor dysfunction in middle cerebral artery occlusion/reperfusion rats though cortex-striatum somatostatin neural circuit","authors":"Yi Zheng , Wenju Wang , Sijia Xia , Tao Jiang , Rui Li , Minguang Yang , Weilin Liu , Lidian Chen , Jing Tao","doi":"10.1016/j.neuroscience.2025.09.012","DOIUrl":"10.1016/j.neuroscience.2025.09.012","url":null,"abstract":"<div><div>Ischemic stroke caused motor dysfunction results poses substantial health burdens and socioeconomic challenges. Electro-acupuncture (EA) at the acupoints of Quchi (LI11) and Zusanli (ST36) has shown positive efficacy in motor dysfunction after stroke. Considering the reported functions of the GABAergic system in locomotion, the present study aims to investigate the detailed mechanism of EA effects on motor regulation, focusing on the neural histological and chemical changes in the GABAergic system. Results demonstrated that EA at LI11 and ST36 improved the modified neurological severity score (mNNS) score and motor function of MCAO/R rats. EA at LI11 and ST36 also prompted γ-aminobutyric acid-ergic (GABAergic) system by the expression of GABA related receptors and GABA interneurons. Here, We have identified long-range projecting GABAergic interneurons, which can be classified into different subtypes based on the molecular markers they express: Parvalbumin (PV+), Somatostatin (SST+), and Vasoactive Intestinal Peptide (VIP+). Additionally, optogenetic stimulation of this projecting neurons can improve the motor dysfunction of MCAO/R rats. Notably, cortex M1-striatum (CS)-SST neural circuit which showed an indescribable role in locomotion improvement under EA intervention. The downregulation of the type II dopamine receptor in medium-sized spiny neurons (DR2-MSNs) and the upregulation of Synaptophysin (SYN) and Postsynaptic Density-95 (PSD95) suggest that MSNs and synaptic plasticity might be the downstream mechanisms of EA treatment at LI11 and ST36. To conclude, EA at LI11 and ST36 can promote synaptic plasticity and improve motor function by targeting and regulate downregulated DR2-MSNs neurons through the CS-SST neural circuit.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 262-278"},"PeriodicalIF":2.8,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of microRNAs targeting oestrogen receptor beta: implications for emotional disorders 预测靶向雌激素受体的microrna：对情绪障碍的影响

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-08 DOI: 10.1016/j.neuroscience.2025.09.011

Daniel Kalinowski, Magdalena Zielińska

{"title":"Prediction of microRNAs targeting oestrogen receptor beta: implications for emotional disorders","authors":"Daniel Kalinowski, Magdalena Zielińska","doi":"10.1016/j.neuroscience.2025.09.011","DOIUrl":"10.1016/j.neuroscience.2025.09.011","url":null,"abstract":"<div><div>This review consolidates the most recent information regarding the role of microRNAs (miRNAs) that target the oestrogen receptor beta (<em>ESR2</em>/ERβ) gene in the pathophysiology of emotional disorders, with a particular emphasis on stress-related conditions and anxiety. Since in silico predictions frequently precede experimental validation and algorithms such as TargetScan and DIANA-microT identified possible miRNA binding sites on <em>ESR2</em> based on sequence complementarity, we demonstrate a high degree of accuracy in predicting functional interactions. Parallel evidence unrelated to the studied biological contexts supports the idea that miRNAs may regulate ERβ signalling in emotional disorders, thereby further supporting miRNA-<em>ESR2</em> interactions. Moreover, the differential expression of circulating miRNAs in clinical conditions has the potential to elucidate underlying mechanisms and serve as biomarkers for anxiety and stress-related disorders, despite scarce studies directly identifying circulating miRNAs targeting ERβ. This review compiles the available data on emotional disorders, miRNAs, and <em>ESR2</em>, highlighting their potential interactions and advocating for the expansion of research to uncover new insights into the molecular underpinnings of these conditions.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 213-221"},"PeriodicalIF":2.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the interaction of reading and attention through connectivity with the frontal-eye-field 通过前眼视野的连通性探索阅读与注意的相互作用。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-04 DOI: 10.1016/j.neuroscience.2025.09.007

Shaylyn Kress , Josh Neudorf , Chelsea Ekstrand , Ron Borowsky

{"title":"Exploring the interaction of reading and attention through connectivity with the frontal-eye-field","authors":"Shaylyn Kress , Josh Neudorf , Chelsea Ekstrand , Ron Borowsky","doi":"10.1016/j.neuroscience.2025.09.007","DOIUrl":"10.1016/j.neuroscience.2025.09.007","url":null,"abstract":"<div><div>Attentional processes are crucial to ensure successful reading, and theories of dyslexia propose that dysfunctional attention networks may contribute to the observed reading deficits. The goals of this study were to localize a region of the frontal-eye-field (FEF) involved in both reading and attention and examine its connectivity with regions in the reading and attention networks, given the known role of the FEF in attentional processes and theorized role in reading. In Experiment 1, we revisited the results of our previous hybrid reading and attention study. We observed a significant reading × attention interaction in BOLD intensity in the FEF, specifically the ventrolateral portion of Brodmann’s Area 6 (A6vl). In Experiment 2, we used Human Connectome Project diffusion tensor imaging data to examine the connectivity profile of the FEF-A6vl. We observed high communicability between the A6vl and basal ganglia (which plays a role in rhythm during syllabic processing). These connections support tract clusters which terminated in the cerebellar Crus I/II (which play roles in eye movements and semantics) and cerebral superior parietal lobule (which plays a role in attentional orienting and phonetic decoding). The results of this study elucidate the reading × attention interaction in the FEF-A6vl, and may have implications for developing treatments to improve reading in individuals with dyslexia.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 249-261"},"PeriodicalIF":2.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blackcurrant anthocyanins improve visual contrast resolution for optokinetic responses in aging mice. 黑加仑花青素改善衰老小鼠光动力学反应的视觉对比度分辨率。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-04 DOI: 10.1016/j.neuroscience.2025.09.003

Yuko Sugita, Koki Kobayashi, Hung-Ya Tu, Daisuke Okuzaki, Takahisa Furukawa

{"title":"Blackcurrant anthocyanins improve visual contrast resolution for optokinetic responses in aging mice.","authors":"Yuko Sugita, Koki Kobayashi, Hung-Ya Tu, Daisuke Okuzaki, Takahisa Furukawa","doi":"10.1016/j.neuroscience.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.09.003","url":null,"abstract":"<p><p>Visual motion perception declines during natural aging in most animals including humans. Edible berries of blackcurrant (BC) and its extracted anthocyanins (BCAs) have beneficial effects on human eyes. However, the effect of BCAs on the perception of moving objects and other dynamic visual patterns remains unknown. In the current study, we investigated whether BCAs improve visual movement perception in aging mice. The aging mice were fed either a standard diet or a standard diet containing BC. In addition, BCAs, the major component of BC, was orally administered to aging mice. The optokinetic responses (OKR) to the vertical sinusoidal patterns were then compared between the groups. To assess the transcriptional effects of delphinidin 3-O-β-rutinoside (D3R), a major BCA, we performed RNA-seq analysis using total RNA purified from the retina and V1 of control and D3R-administered aging mice. Larger OKRs were observed in BC-fed mice than in control mice at low grating contrast, suggesting that the contrast resolution to track moving patterns was improved. Similar results were observed in mice orally administered BCAs. Furthermore, we examined the effects of BCAs on the aging mouse retina and the primary visual cortex (V1) at the gene expression level. RNA-seq analysis of BCA-administered aging mouse retinas and V1s indicated activation of genes related to neural protection and neuronal survival, including BDNF and EGF. Taken together, the current study suggests that BCA ingestion alleviates the decline in contrast-dependent moving visual function in aging mice, accompanied by transcriptional profile change of the V1 and retina.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive prediction using regional connectivities and network biomarkers in Alzheimer’s disease 阿尔茨海默病中使用区域连接和网络生物标志物的认知预测。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-03 DOI: 10.1016/j.neuroscience.2025.08.059

Jinhua Sheng , Jialei Wang , Qiao Zhang , Ruilin Huang , Yan Lu , Tao Li

{"title":"Cognitive prediction using regional connectivities and network biomarkers in Alzheimer’s disease","authors":"Jinhua Sheng , Jialei Wang , Qiao Zhang , Ruilin Huang , Yan Lu , Tao Li","doi":"10.1016/j.neuroscience.2025.08.059","DOIUrl":"10.1016/j.neuroscience.2025.08.059","url":null,"abstract":"<div><div>Achieving a deep understanding of brain mechanisms requires multi-scale perspectives to capture the architecture of complex networks. In this study, we focused on patients with cognitive impairment and constructed individual brain networks from neuroimaging data. We introduced a Significant Edges Selection (SES) method, which effectively extracts the most informative connections while suppressing noise. Using these refined features, we computed network characteristics and applied machine learning models to predict cognitive performance, achieving a prediction accuracy of correlation r = 0.683 under rigorous leave-one-out cross-validation. Importantly, we identified core brain regions and large-scale networks that drive predictive performance. Specifically, the secondary visual (VIS2), frontoparietal control (FPN), and default mode (DMN) networks emerged as the most strongly associated with cognitive decline. Our findings highlight a multi-scale framework, spanning connections, brain regions, and networks, that not only yields robust cognitive prediction but also provides novel insights into AD-related mechanisms. This work advances predictive modeling in Alzheimer’s Disease (AD) and offers valuable guidance for early diagnosis and mechanistic research.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 313-322"},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of glucocorticoid receptors facilitates ex vivo high-frequency network oscillations in the anterior cingulate cortex 糖皮质激素受体的激活促进了前扣带皮层的离体高频网络振荡

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-03 DOI: 10.1016/j.neuroscience.2025.09.002

Daniel Frías Donaire , Yunus Emre Demiray , Ares Alizade , Evangelia Pollali , Anne Albrecht , Gürsel Çalışkan

{"title":"Activation of glucocorticoid receptors facilitates ex vivo high-frequency network oscillations in the anterior cingulate cortex","authors":"Daniel Frías Donaire , Yunus Emre Demiray , Ares Alizade , Evangelia Pollali , Anne Albrecht , Gürsel Çalışkan","doi":"10.1016/j.neuroscience.2025.09.002","DOIUrl":"10.1016/j.neuroscience.2025.09.002","url":null,"abstract":"<div><div>Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, releasing corticosterone (CORT), which binds to glucocorticoid (GR) and mineralocorticoid (MR) receptors in the brain. While stress influences behaviorally relevant network oscillations in limbic regions such as the hippocampus, amygdala, and prefrontal cortex, the direct effects of CORT on these oscillations remain unclear. We examined the acute impact of CORT on anterior cingulate cortex (ACC) oscillations in adult male mice, a hub region for stress and anxiety regulation. Using an ex vivo slice model with cholinergic and glutamatergic activation, we induced beta (10–25 Hz) and slow-gamma (26–45 Hz) oscillations. Our findings show that CORT enhances high-frequency network activity in the ACC in a dose-dependent manner, following an inverted U-shaped dose–response curve, with 1 μM CORT producing significant increases in beta and gamma power. GR activation alone reproduced this effect: the GR agonist dexamethasone mimicked, and the GR antagonist mifepristone blocked, CORT-induced enhancement. MR activation had little effect, and MR antagonism did not prevent the action of CORT. Importantly, acute stress induced by fear conditioning elevated serum CORT levels and enhanced ACC oscillatory activity, with a positive correlation between CORT concentration and oscillation power. Both GR and MR were robustly expressed in the ACC, with expression unaffected by acute stress. These findings highlight the critical role of GR in mediating the effects of CORT on ACC oscillations, which could have implications for understanding neuropsychiatric disorders including anxiety, depression and schizophrenia, where HPA dysfunction, impaired GR signaling, and altered ACC oscillatory activity are commonly observed.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 144-157"},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and implementation of a writing-stroke motor imagery paradigm for multi-character EEG classification. 多字脑电分类笔画运动意象范式的设计与实现。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-02 DOI: 10.1016/j.neuroscience.2025.08.058

Hongguang Pan, Hongzheng Gao, Yibo Zhang, Xinyu Yu, Zhuoyi Li, Xinyu Lei, Wenyu Mi

{"title":"Design and implementation of a writing-stroke motor imagery paradigm for multi-character EEG classification.","authors":"Hongguang Pan, Hongzheng Gao, Yibo Zhang, Xinyu Yu, Zhuoyi Li, Xinyu Lei, Wenyu Mi","doi":"10.1016/j.neuroscience.2025.08.058","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.08.058","url":null,"abstract":"<p><p>Motor imagery (MI) based brain-computer interfaces (BCI) decode neural activity to generate command outputs. However, the limited number of distinguishable commands in traditional MI-BCI systems restricts practical applications. To overcome this limitation, we propose a multi-character classification framework based on Electroencephalography (EEG) signals. A structurally simplified MI paradigm for stroke writing is designed, and maximize Euclidean distance trajectory optimization enhances neural separability among five stroke categories. The EEG data cover 11 motor imagery tasks, including five stroke-writing tasks and six related movement tasks such as hand, foot, tongue movements and eye blinks, collected from ten participants. Ensemble Empirical Mode Decomposition (EEMD) eliminates artifact-related Intrinsic Mode Functions (IMFs) and reconstructs the signals. Kernel Principal Component Analysis (KPCA) then conducts nonlinear dimensionality reduction to extract discriminative features. Finally, a recurrent neural network based on Gated Recurrent Units (GRU) performs classification, effectively modeling the temporal dynamics of EEG signals. Experimental results indicate that the optimized stroke paradigm achieves an average classification accuracy of 84.77%, outperforming the unoptimized version at 76.83%. Compared to existing MI-BCI methods, the proposed framework improves classification accuracy and expands the set of distinguishable commands, demonstrating enhanced practicality and effectiveness.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen sulfide in the brain as a silent neuroprotector in Alzheimer’s disease 大脑中的硫化氢作为阿尔茨海默病的无声神经保护器。

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-02 DOI: 10.1016/j.neuroscience.2025.08.057

Himanshu Layal , Jitumani Rajbongshi , Rohit Kumar , Shambhavi Pandey , Rajeev Mishra , Pramod K. Yadav

{"title":"Hydrogen sulfide in the brain as a silent neuroprotector in Alzheimer’s disease","authors":"Himanshu Layal , Jitumani Rajbongshi , Rohit Kumar , Shambhavi Pandey , Rajeev Mishra , Pramod K. Yadav","doi":"10.1016/j.neuroscience.2025.08.057","DOIUrl":"10.1016/j.neuroscience.2025.08.057","url":null,"abstract":"<div><div>Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gasotransmitter that has garnered growing attention for its critical roles in cellular signalling and brain function. It regulates NMDA receptors during long-term potentiation, a fundamental mechanism underlying memory consolidation and influences neurotransmission and essential neurophysiological functions. H<sub>2</sub>S is synthesized by three enzymes: cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MST) within the cell. CBS is suggested to be the primary source of H<sub>2</sub>S in the brain parenchyma, while CSE and MST predominantly contribute to its production in cerebral microvessels and astrocytes, respectively. This gasotransmitter plays a pivotal role in modulating hippocampal memory formation, reducing inflammation, promoting vasorelaxation, and supporting angiogenesis. It has been suggested to act as a second messenger or neurotransmitter in the brain, typically activated by neuronal excitation. H<sub>2</sub>S has been widely investigated for its therapeutic potential in Alzheimer’s disease. Notably, Alzheimer’s disease patients display significantly diminished levels of H<sub>2</sub>S compared to age matched subjects. This review offers a consolidated and updated role of H<sub>2</sub>S in Alzheimer’s disease, emphasizing recent mechanistic advances not covered in earlier literature. The work presents a novel perspective by integrating emerging findings on H<sub>2</sub>S based neurotherapeutic strategies.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 181-197"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A single-center retrospective study on clinical features and outcomes of perimesencephalic non-aneurysmal subarachnoid hemorrhage patients 脑实质周围非动脉瘤性蛛网膜下腔出血患者的临床特征及预后的单中心回顾性研究

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-02 DOI: 10.1016/j.neuroscience.2025.08.064

Chenchen Wang , Xu Wang , Yang Gao , Yuwei Han, Da Huo, Xiaoming Li, Guobiao Liang

{"title":"A single-center retrospective study on clinical features and outcomes of perimesencephalic non-aneurysmal subarachnoid hemorrhage patients","authors":"Chenchen Wang , Xu Wang , Yang Gao , Yuwei Han, Da Huo, Xiaoming Li, Guobiao Liang","doi":"10.1016/j.neuroscience.2025.08.064","DOIUrl":"10.1016/j.neuroscience.2025.08.064","url":null,"abstract":"<div><div>Perimesencephalic non-aneurysmal subarachnoid hemorrhage (pmSAH) is a subtype of subarachnoid hemorrhage (SAH) where the bleeding source remains unclear. It is generally associated with a benign clinical course compared to other SAH types. This study retrospectively analyzed 198 pmSAH patients admitted between January 2019 and December 2023, along with 137 non-perimesencephalic non-aneurysmal subarachnoid hemorrhage (npmSAH) and 198 aneurysmal SAH patients as controls. Results showed that pmSAH incidence accounted for approximately 5.6% of all SAH cases and 59.1% of non-aneurysmal SAH cases. pmSAH patients exhibited milder clinical severity, with higher Glasgow Coma Scale scores and lower Hunt-Hess grades compared to aSAH and npmSAH patients. At onset, pmSAH patients were less likely to experience loss of consciousness, incontinence, or convulsions. They also had fewer complications, shorter hospital stays, and a lower proportion of poor prognosis. Multivariate logistic regression identified complications and Hunt-Hess grade as independent risk factors for poor prognosis in pmSAH. In conclusion, pmSAH patients demonstrated relatively mild clinical courses, fewer complications, and better prognosis. However, occasional occurrences require further attention.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 71-77"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of vestibular afference to estimation of centre of mass state for stabilization of walking differs between anteroposterior and mediolateral directions 前庭参考对稳定行走的重心状态估计的贡献在正前方和中外侧方向上是不同的

IF 2.8 3区医学

Neuroscience Pub Date : 2025-09-01 DOI: 10.1016/j.neuroscience.2025.08.066

Yiyuan C. Li , Koen K. Lemaire , Sjoerd M. Bruijn , Simon Brumagne , Jaap H. van Dieën

{"title":"Contribution of vestibular afference to estimation of centre of mass state for stabilization of walking differs between anteroposterior and mediolateral directions","authors":"Yiyuan C. Li , Koen K. Lemaire , Sjoerd M. Bruijn , Simon Brumagne , Jaap H. van Dieën","doi":"10.1016/j.neuroscience.2025.08.066","DOIUrl":"10.1016/j.neuroscience.2025.08.066","url":null,"abstract":"<div><div>Walking without falling requires correcting the deviations of the centre of mass (CoM) trajectory relative to the base of support. This process is partially under feedback control. We investigated whether vestibular afference contributes to estimating CoM state to stabilize walking. We disturbed the vestibular afference by electrical vestibular stimulation (EVS), which typically leads to responses coherent with the stimulus and directed opposite to movement direction encoded by the induced vestibular signal. With the head facing forward, EVS induces mediolateral perturbations, which shift into the anteroposterior direction when the head is turned sideward in standing. Thirteen participants walked on a treadmill for 8 min at 78 steps/min and 2.8 km/h in four conditions, defined by the presence of EVS and head orientations (facing forward or leftward). A linear regression between the CoM state, described as the extrapolated CoM, and the delayed ground reaction force (GRF) was fitted, which was used to identify a ‘feedback model’. Negative correlations were found in all conditions, indicating that delayed compensatory actions are modulated to correct the deviation of CoM state. EVS significantly increased the magnitude of the GRF not predicted by the XCoM, i.e. the residual error of the feedback model. Contrary to our hypothesis, the increase in the anteroposterior direction was significantly smaller when walking with head facing leftward than when facing forward. Our findings indicate that vestibular afference contributes to estimating CoM state for walking stabilization in the mediolateral direction, but they do not support such a contribution for the anteroposterior direction.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"585 ","pages":"Pages 40-49"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0