Neuroscience最新文献_第3页

Fiber correlational tractography with neurovascular coupling and cognition in hypertension. 高血压患者神经血管耦合与认知的纤维相关导管造影。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-24 DOI: 10.1016/j.neuroscience.2025.06.004

Manuel Fortunato, Ricardo Morais, Isabel Santana, Pedro Castro, Jorge Polónia, Elsa Azevedo, João Paulo Cunha, Ana Monteiro

{"title":"Fiber correlational tractography with neurovascular coupling and cognition in hypertension.","authors":"Manuel Fortunato, Ricardo Morais, Isabel Santana, Pedro Castro, Jorge Polónia, Elsa Azevedo, João Paulo Cunha, Ana Monteiro","doi":"10.1016/j.neuroscience.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.06.004","url":null,"abstract":"<p><p>Hypertension is the primary risk factor for cerebral small vessel disease (CSVD). However, its mechanistic links are yet to be completely understood. Advancements in diffusion-weighted magnetic resonance imaging (dMRI) increased sensitivity in detecting subtle white matter (WM) structural integrity changes. 44 hypertension patients without symptomatic CSVD underwent multi-modal evaluation of cerebral structure and function, including dMRI, neuropsychological tests and transcranial Doppler monitoring of the right middle cerebral artery (MCA) and left posterior cerebral artery (PCA) to assess neurovascular coupling (NVC). In the PCA, the modeled NVC curve was studied. We examined the cross-sectional relationship of WM integrity with NVC and cognitive performance, using correlational tractography. Diffusion measures from two dMRI models were used: fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity from diffusion tensor imaging, and quantitative anisotropy (QA) and isotropy from q-space diffeomorphic reconstruction. Regarding the NVC in the PCA, vascular elastic properties and initial response speed markers indicated better functional hyperemia with better WM integrity. However, the amplitude suggested increased NVC with worse WM integrity. In the MCA, increased NVC was associated with lower WM integrity. Better cognitive performance associated with preserved WM integrity. Increased functional hyperemia despite worse WM integrity may reflect less efficient NVC in hypertensive patients, potentially arising from (mal)adaptive mechanisms and brain network reorganization in response to CSVD. This observational study highlights the potential of transcranial Doppler and QA as susceptibility markers of pre-symptomatic CSVD.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neural control of accurate hand force production. 精确手力产生的神经控制。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-24 DOI: 10.1016/j.neuroscience.2025.06.051

Sayan Deep De, Janina M Prado-Rico, Mark L Latash

{"title":"The neural control of accurate hand force production.","authors":"Sayan Deep De, Janina M Prado-Rico, Mark L Latash","doi":"10.1016/j.neuroscience.2025.06.051","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.06.051","url":null,"abstract":"<p><p>We addressed the controversy on the relative role of the reciprocal and coactivation commands in the neural control of force in multi-finger tasks. Specifically, we tested the hypothesis that a mechanical variable serving as a proxy of the coactivation command will scale with force magnitude. We also explored indices of force-stabilizing synergies assessed at the level of the reciprocal and coactivation commands to the hand and to the individual fingers and at the level of finger coordination. Healthy subjects performed a ramp-and-hold isometric force production to various force magnitudes. An \"inverse piano\" device was used to estimate mechanical reflections of the reciprocal and coactivation commands at steady states. The uncontrolled manifold framework was used to estimate synergy indices. Mechanical reflections of both commands showed significant linear scaling with the force magnitude, stronger for the coactivation command. Over multiple repetitions, the two commands showed strong hyperbolic covariation, the strongest for the whole hand, and the weakest for the little finger. There were four-finger force-stabilizing synergies. However, the indices of two types of synergies, four-finger and reciprocal-coactivation ones, showed no significant correlation. We interpret the results as pointing at two sources of supraspinal synergies tentatively associated with subcortical circuitry and cortical mechanisms. During voluntary movements, the reciprocal command has an advantage and may be hierarchically higher than the coactivation command. During force-production tasks, changes in the coactivation command are used more consistently to fit the task. The results suggest that movement generation and force production tasks may involve qualitatively different control strategies.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-ingredient energy dietary supplement with a small amount of caffeine modulates central and autonomic nervous system after a single use 含有少量咖啡因的多成分能量膳食补充剂，一次使用后可调节中枢和自主神经系统

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-23 DOI: 10.1016/j.neuroscience.2025.06.049

Karina Maciejewska , Klaudia Duch , Maciej Giza , Aleksandra Nas

{"title":"Multi-ingredient energy dietary supplement with a small amount of caffeine modulates central and autonomic nervous system after a single use","authors":"Karina Maciejewska , Klaudia Duch , Maciej Giza , Aleksandra Nas","doi":"10.1016/j.neuroscience.2025.06.049","DOIUrl":"10.1016/j.neuroscience.2025.06.049","url":null,"abstract":"<div><div>Most research on the impact of neurostimulatory substances on brain function and human behavior focuses on the adverse effects of their high doses or long-term use. However, little is known about the impact of single doses that contain psychostimulants only in a small amount. Therefore, we investigated the acute effect of an energy dietary multi-ingredient supplement with a low amount of caffeine (55 mg) on the ANS in a double-blind, placebo-controlled study (47 participants, 27 women). Previously, we reported its impact on the activity of the CNS through changes in the resting state EEG (rsEEG) pattern and event-related brain potentials by reversing the fatigue-related brain activity. Here, we show that supplementation also influences the ANS through changes in heart electrophysiology. The supplement changed the PRQ and QTc intervals in the ECG signal. In addition, LF power changes were correlated with the changes in rsEEG, which we reported earlier. These findings show that a single dose of dietary supplementation with a much smaller dose of caffeine than in typical caffeinated products may still impact both the CNS and ANS. The results indicate that using such products before electrophysiological examinations in research, diagnostics, and treatment should be considered to control confounding factors. Finally, since the effects were elicited by an energy boost supplement in the mentally fatigued participants, it may be of special importance and enable translation into treatments related to attention, anxiety, mood, and memory disorders.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 194-208"},"PeriodicalIF":2.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Article for the Virtual Special Issue: Celebrating the 30th anniversary of the Uruguayan Society for Neuroscience: Emergent topics from South America to global neuroscience 虚拟特刊社论文章：庆祝乌拉圭神经科学学会成立30周年：从南美洲到全球神经科学的新兴主题。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-21 DOI: 10.1016/j.neuroscience.2025.06.045

Ana Silva (Guest Editor), Nathalia Vitureira (Guest Editor), Flavio R. Zolessi (Guest Editor)

引用次数: 0

ATF3 mediates high-salt diet-induced exacerbation of ischemic stroke: therapeutic potential of theta-burst stimulation ATF3介导高盐饮食诱导的缺血性卒中加重：脑波爆发刺激的治疗潜力

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-21 DOI: 10.1016/j.neuroscience.2025.06.046

Youxin Yu , Yu Shi , Ziwei Hu , Jiahui Pang , Xianglong Wang , Sishi Liu , Yu Xie , Wen Wu

{"title":"ATF3 mediates high-salt diet-induced exacerbation of ischemic stroke: therapeutic potential of theta-burst stimulation","authors":"Youxin Yu , Yu Shi , Ziwei Hu , Jiahui Pang , Xianglong Wang , Sishi Liu , Yu Xie , Wen Wu","doi":"10.1016/j.neuroscience.2025.06.046","DOIUrl":"10.1016/j.neuroscience.2025.06.046","url":null,"abstract":"<div><div>Acute ischemic stroke (AIS), a high-risk condition associated with significant morbidity and disability, could be further exacerbated by a high-salt diet (HSD). Although intermittent theta-burst stimulation (iTBS) is a clinically effective rehabilitation modality, its neuroprotective mechanisms remain unclear. This study aimed to elucidate the pathways through which HSD exacerbates early AIS injury, identify potential biomarkers, and assess the impact of iTBS intervention. First, bioinformatics techniques were employed to identify core genes associated with early ischemia and differentially expressed microglial genes (DEMGs) in mice subjected to middle cerebral artery occlusion (MCAO) with or without HSD. Subsequently, key pathways enriched among these DEMGs were elucidated. Next, co-expressed genes linked to HSD-exacerbated AIS mechanisms were selected as potential biomarkers and validated in vivo and in vitro. Finally, iTBS effects on biomarker expression were evaluated. As a result, integrative bioinformatics analysis implicated ATF3 as a potential biomarker for HSD-exacerbated AIS injury, mechanistically linked to HSD-induced microglial apoptosis. Consistently, HSD significantly upregulated ATF3 expression in both in vivo and in vitro AIS models. Furthermore, iTBS intervention significantly downregulated ATF3 expression within the HSD-exacerbated AIS context. Critically, iTBS also specifically downregulated ATF3 expression notably within hippocampal microglia of HSD-fed MCAO mice. Collectively, these findings suggest ATF3 serves as a potential biomarker for the combined injury induced by HSD and AIS and represents a promising therapeutic target for iTBS.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 124-138"},"PeriodicalIF":2.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting CXCR4 and TRPV1 with α-Conopeptide G1 derived from Conus for Glioblastoma: an integrative in-silico and network pharmacology approach 用Conus衍生的α- conop肽G1靶向CXCR4和TRPV1治疗胶质母细胞瘤：一种集成的计算机和网络药理学方法

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-21 DOI: 10.1016/j.neuroscience.2025.06.047

Sandhanam Kuppusamy, Sumithra Mohan

{"title":"Targeting CXCR4 and TRPV1 with α-Conopeptide G1 derived from Conus for Glioblastoma: an integrative in-silico and network pharmacology approach","authors":"Sandhanam Kuppusamy, Sumithra Mohan","doi":"10.1016/j.neuroscience.2025.06.047","DOIUrl":"10.1016/j.neuroscience.2025.06.047","url":null,"abstract":"<div><div>Glioblastoma (GBM) was identified as a highly aggressive and lethal primary brain tumor of the central nervous system, marked by significant inter- and intra-tumoral heterogeneity that limited therapeutic efficacy. This study aimed to target glioblastoma stem cells (GSCs) using α-conopeptide GI, employing an <em>in-silico</em> approach to identify and validate therapeutic pathways. Swiss Target Prediction identified 100 potential target genes, and toxicity analysis of α-conopeptide GI demonstrated minimal toxicity. Structural validation using a ramachandran plot confirmed the peptide’s stability, referencing the PDB code 1NOT. Further pathway analyses narrowed the focus to 50 common hub genes using DisGeNET and Venn diagram analysis. STRING network analysis for Protein-Protein Interaction (PPI) interaction conducted using Cytoscape, highlighted key genes with high degree values, including C-X-C chemokine receptor type 4 (CXCR4-score: 31) and transient receptor potential vanilloid 1 (TRPV1-score: 29). Functional annotation through Kyoto encyclopedia of genes and genomes pathway and Gene Ontology analysis linked these genes to critical pathways in cancer, angiogenesis, and IL-17 signaling. Molecular docking studies using ClusPro and Schrödinger software demonstrated strong binding affinities of α-conopeptide GI with CXCR4 (ΔG: −10.7 kcal/mol) and TRPV1 (ΔG: −9.3 kcal/mol). Molecular dynamics simulations further validated these interactions, with Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), and ligand torsion profiles falling within optimal ranges (1–3Å). These findings suggested that α-conopeptide GI, derived from Conus geographus, held promise as a therapeutic agent for GBM by targeting tumor recurrence and angiogenesis. Further <em>in-vitro</em> and <em>in-vivo</em> studies are required to confirm its clinical potential.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 139-168"},"PeriodicalIF":2.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “JLX001 Ameliorates ischemia/reperfusion injury by reducing neuronal apoptosis via downregulating JNK signaling pathway” [Neuroscience 418 (2019) 189–204] “JLX001通过下调JNK信号通路减少神经元凋亡改善缺血/再灌注损伤”[神经科学]418(2019)189-204]更正

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-21 DOI: 10.1016/j.neuroscience.2025.06.027

Lin Zhou , Lu-yao Ao , Yun-yi Yan , Wan-ting Li , An-qi Ye , Cheng-yuan Li , Wei-yang Shen , Bing-wen Liang , Xiong-Zhu , Yun-man Li

引用次数: 0

Transcriptomic analysis reveals novel targets in benign schwannoma using machine learning. 利用机器学习转录组学分析揭示良性神经鞘瘤的新靶点。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-21 DOI: 10.1016/j.neuroscience.2025.06.048

Suwei Yan, Jingnan Zhao, Pengyang Gao, Zhaoxu Li, Zhao Li, Pengfei Wang

{"title":"Transcriptomic analysis reveals novel targets in benign schwannoma using machine learning.","authors":"Suwei Yan, Jingnan Zhao, Pengyang Gao, Zhaoxu Li, Zhao Li, Pengfei Wang","doi":"10.1016/j.neuroscience.2025.06.048","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.06.048","url":null,"abstract":"<p><strong>Background & objective: </strong>This study aimed to identify key immune-related biomarkers of benign schwannoma through machine learning-assisted transcriptomic and single-cell analyses, and to construct a predictive model for disease evaluation.</p><p><strong>Methods: </strong>Transcriptomic data from the GSE108524 dataset were utilized for immune subtyping and immune cell infiltration analysis. Key biomarkers were screened using the Least Absolute Shrinkage and Selection Operator (LASSO), Support Vector Machine (SVM), and Random Forest algorithms. A nomogram-based predictive model was developed (area under the curve [AUC] = 0.67) and evaluated using accuracy, sensitivity, specificity, and F1-score metrics. The distribution of identified biomarkers across immune cell subsets was validated using scRNA-seq, with a particular focus on T cells and macrophages. Functional roles of ANGPTL1, IL17RC, LTBR, OLR1, and TGFBR1 were further verified through in vitro assays and in vivo using an NF2-knockout mouse model.</p><p><strong>Results: </strong>Five immune-related biomarkers were identified. Among them, ANGPTL1 and IL17RC inhibited tumor cell proliferation and migration, whereas LTBR, OLR1, and TGFBR1 promoted these processes. These genes exhibited differential expression across immune subtypes and were enriched in tumor-associated immune cells. Both in vitro and in vivo experiments substantiated their biological significance in schwannoma progression.</p><p><strong>Conclusion: </strong>This study identifies five novel immune-related biomarkers with functional relevance in benign schwannoma, providing new insights into its immune microenvironment and tumor biology. The predictive model offers a foundation for risk stratification and personalized therapeutic strategies. These findings complement known markers such as NF2, SOX10, and S100B, highlighting their potential translational value as diagnostic and therapeutic targets.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of ER stress mitigates hypobaric hypoxia-induced retinal damage: a simulated high-altitude study 内质网应激抑制减轻低氧缺氧引起的视网膜损伤：一项模拟高海拔研究。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-20 DOI: 10.1016/j.neuroscience.2025.06.044

Xingxing Zheng , Cong Han , Yi Yang , Wenfang Zhang

{"title":"Inhibition of ER stress mitigates hypobaric hypoxia-induced retinal damage: a simulated high-altitude study","authors":"Xingxing Zheng , Cong Han , Yi Yang , Wenfang Zhang","doi":"10.1016/j.neuroscience.2025.06.044","DOIUrl":"10.1016/j.neuroscience.2025.06.044","url":null,"abstract":"<div><div>High Altitude Retinopathy (HAR) is a pathological disorder characterized by damage to the optic nerve and retina due to hypobaric hypoxia at high altitudes. Despite its clinical importance, the underlying etiology and effective therapeutic strategies for HAR remain poorly understood and limited. In this study, we developed a murine model of acute HAR using a standardized high-altitude simulation chamber. We conducted retinal transcriptomic sequencing and bioinformatics analysis in the simulated HAR mice, with a particular focus on the significantly enriched endoplasmic reticulum (ER) stress PERK pathway. Using Western Blotting and quantitative real-time polymerase chain reaction (qRT-PCR) experiments, we verified that significant ER stress occurred in the retinas of HAR mice. Subsequently, we employed Propidium Iodide (PI)/Hoechst Staining and Flow Cytometry Analysis to demonstrate that the ER stress inhibitor Salubrinal reduced necrosis and apoptosis in mouse retinal photoreceptor cells (661W cell line) under hypoxic conditions. Furthermore, via Transmission Electron Microscopy (TEM), Optical Coherence Tomography (OCT), Hematoxylin and Eosin (H&E) staining, and Electroretinography (ERG), we confirmed that Salubrinal could alleviate hypobaric hypoxia-induced retinal edema and enhance retinal function by inhibiting the ER stress level of the PERK/eIF2α/ATF4/CHOP pathway in HAR mice. Our findings indicate that targeting the ER stress PERK pathway may be a promising therapeutic approach for managing HAR, offering potential clinical implications for treating this altitude-related ocular disorder.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 181-193"},"PeriodicalIF":2.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic magic: How stimulation alters feeding patterns in Aplysia californica 磁魔法：刺激如何改变加州的进食模式。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.040

Jayden Ye , Justin Lu , Lindsay Ye , Maria Dima , David Brynski , Jenna Hendee , Hui Ye

{"title":"Magnetic magic: How stimulation alters feeding patterns in Aplysia californica","authors":"Jayden Ye , Justin Lu , Lindsay Ye , Maria Dima , David Brynski , Jenna Hendee , Hui Ye","doi":"10.1016/j.neuroscience.2025.06.040","DOIUrl":"10.1016/j.neuroscience.2025.06.040","url":null,"abstract":"<div><div>Repetitive transcranial magnetic stimulation (rTMS) is emerging as a groundbreaking treatment for eating disorders, such as anorexia and bulimia nervosa, though its underlying neurological mechanisms remain elusive. To shed light on the effects of rTMS on neural control of feeding behavior, we investigated the feeding responses in the marine mollusk <em>Aplysia californica</em>. Using <em>in vitro</em> preparations, we elicited feeding responses and performed dual nerve recordings to identify motor programs associated with rejection and ingestion. We applied rTMS to the cerebral ganglion, the neural center responsible for switching between ingestion and rejection behaviors. At a clinically relevant frequency of 10 Hz, rTMS terminated rejection responses and promoted ingestion responses in the buccal ganglion, which directly executes feeding behaviors. Direct stimulation of the buccal ganglion or lesioning the connection between the cerebral and buccal ganglia prevented the rTMS-mediated transition from rejection to ingestion. These findings establish <em>Aplysia</em> as a pivotal model for studying the cellular and molecular basis of rTMS in the treatment of eating disorders, underscoring the remarkable adaptability of neural circuits and paving the way for transformative advancements in therapeutic applications.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 88-98"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0