Neuroscience最新文献

{"title":"Resting-state voxel-wise dynamic effective connectivity predicts risky decision-making in patients with bipolar disorder type I","authors":"Shanling Ji ,&nbsp;Hongyong Zhang ,&nbsp;Cong Zhou ,&nbsp;Xia Liu ,&nbsp;Chuanxin Liu ,&nbsp;Hao Yu","doi":"10.1016/j.neuroscience.2024.11.024","DOIUrl":"10.1016/j.neuroscience.2024.11.024","url":null,"abstract":"<div><div>Patients with Bipolar Disorder type I (BD-I) exhibit maladaptive risky decision-making, which is related to impulsivity, suicide attempts, and aggressive behavior. Currently, there is a lack of effective predictive methods for early intervention in risky behaviors for patients with BD-I. This study aimed to predict risky behavior in patients with BD-I using resting-state functional magnetic resonance imaging (rs-fMRI). We included 48 patients with BD-I and 124 healthy controls (HC) and constructed voxel-wise functional connectivity (FC), dynamic FC (dFC), effective connectivity (EC), and dynamic EC (dEC) for each subject. The Balloon Analogue Risk Task (BART) was employed to measure the risky decision-making of all participants. We applied connectome-based predictive modeling (CPM) with five regression algorithms to predict risky behaviors as well as Barratt Impulsivity Scale (BIS) scores. Results showed that the BD-I had significantly lower risky adjusted pump scores compared to HC. The dEC-based linear regression-CPM model exhibited significant predictive ability for the adjusted pump scores in BD-I, while no significant predictive power was observed in HC. Furthermore, this model successfully predicted non-planning impulsiveness, motor impulsiveness, and BIS total score, but failed for attentional impulsiveness in BD-I. These findings provide a foundation for future work in predicting risky behaviors of psychiatric patients by using voxel-wise dEC underlying resting state.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"564 ","pages":"Pages 135-143"},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA is a potent immunoinflammatory target in asymptomatic Alzheimer's disease.","authors":"Yingwei Zheng, Xiaobo Yu, Wenwen Li, Fan Wu, Yunlu Gu, Keyao Liu, Sijue Tao, Yue Liu, Qian Wang","doi":"10.1016/j.neuroscience.2024.11.049","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.049","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a common neurodegenerative disease, neuroinflammation is an early pathological feature of AD. However, the alteration of the immune microenvironment in asymptomatic AD was not fully explained. In this study, we aimed to utilize the transcriptome data of AD patients in public databases to reveal the change of immune microenvironment in asymptomatic AD and screen the potential anti-AD drug. Through a series of bioinformatics analyses, differentially expressed genes (DEGs) screening, enrichment analysis, PPI network construction, and hub gene identification were done. Meanwhile, the hub genes were validated in APP/PS-1(AD) mice. Importantly, seven enrichment pathways and eight hub genes associated with inflammation were identified in asymptomatic AD. Early AD patients presented infiltration of immunoinflammatory cells to varying degrees in the four representative brain regions. Correspondingly, more hub genes changed in the hippocampus in AD mice compared to the other four brain regions. Accompanied by the activation of microglia and astrocytes, the inflammation cytokines were increased in the hippocampus of AD mice. Moreover, HLA-C was correlated with the activation of microglia, HLA-DRB1 with IL-6 and OAS2 with TGF-β1 in the hippocampus. Five FDA-approved drugs (Itrazole, Dfo, Syrosingopine, Cefoperazone and Pradaxa) were predicted as the common drug-targeted HLA-C and HLA-DRB1 by molecular docking. Taken together, the changes in the immune microenvironment of asymptomatic AD, and provided a new perspective for the development of anti-inflammatory drugs for AD early treatment.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent seizure impacts oligodendrocyte maturation, neuronal-glial circuit Formation, and myelination in the mammalian forebrain","authors":"Kylie Foutch ,&nbsp;Iris Tilton ,&nbsp;Aundrea Cooney ,&nbsp;Cole Bender ,&nbsp;Collin Licharz ,&nbsp;Megan Baldemor ,&nbsp;Caitlyn Rock ,&nbsp;Atehsa Asal Sahagun ,&nbsp;Robert Brock ,&nbsp;Chloe Franzia ,&nbsp;Mary Francis Garcia ,&nbsp;Raghav Gupta ,&nbsp;Christopher Arellano Reyes ,&nbsp;Mariyam Lokhandwala ,&nbsp;Daniela Moura ,&nbsp;Hirofumi Noguchi ,&nbsp;Laura Cocas","doi":"10.1016/j.neuroscience.2024.11.050","DOIUrl":"10.1016/j.neuroscience.2024.11.050","url":null,"abstract":"<div><div>Oligodendrocyte progenitor cells differentiate into oligodendrocytes, which myelinate axons during development and following demyelinating injury. However, the mechanisms that drive the timing and specificity of developmental myelination are not well understood. We hypothesized that oligodendrocyte progenitor cell proliferation and differentiation would be affected by pathological neuronal activity during adolescent development when developmental myelination is occurring and that this would also impact neuron-to-oligodendrocyte progenitor cell connectivity and myelination. We used kainic acid to induce a seizure in mice, treating equal numbers of males and females, in sample sizes of at least five animals. We found that the seizures led to increased cell death overall, specifically in the oligodendrocyte-lineage cells. We found that both oligodendrocyte progenitor cell proliferation and overall numbers increased, and the number of mature oligodendrocytes decreased. We found a decrease in myelin in the cerebral cortex, corpus callosum, and hippocampus after a seizure. We observed an increase in demyelinating lesions, but no change in neuronal process length, in brains after seizure, suggesting that the demyelination was due primarily to the loss of both oligodendrocyte-lineage cells. We found that Kir4.1 potassium channel expression on oligodendrocyte progenitor cells decreased after seizure, but not mature oligodendrocytes. Finally, we found a decrease in neuron-to-oligodendrocyte progenitor cell connections in seizure mice compared to controls. These findings provide insight into the response of the adolescent brain to seizure activity, as well as how seizures affect oligodendrocyte development, neuronal-glial connections, and myelin formation.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"564 ","pages":"Pages 144-159"},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal and spatial layout of endocannabinoid system components in the mouse suprachiasmatic nucleus","authors":"Timothy D. Niepokny ,&nbsp;Hunter Frey-Burkart ,&nbsp;Eric M. Mintz","doi":"10.1016/j.neuroscience.2024.11.026","DOIUrl":"10.1016/j.neuroscience.2024.11.026","url":null,"abstract":"<div><div>Environmental light serves as the main entraining signal for the central circadian pacemaker, the suprachiasmatic nucleus of the hypothalamus (SCN). To shift clock timing with the changing environment, minute adjustments are necessary and the endocannabinoid system (ECS) acts as a neuromodulatory signaling mechanism in the SCN. These systems exert bidirectional effects on one another, still, limited knowledge exists about the role of endocannabinoids in circadian rhythm regulation. Therefore, we investigated the temporal and spatial molecular layouts of the ECS in the SCN of male and female C57BL/6J mice. We utilized laser capture microdissection and quantitative RT-PCR to investigate the ECS temporal layout in the SCN, detected 13 of 19 examined ECS components, and followed up with two 24-hour time course experiments, one under 12:12 light/dark and one under constant dark conditions. All enzymatic machinery related to endocannabinoid synthesis and degradation investigated were found present; however, only cannabinoid receptor 1 (<em>Cnr1</em>) was detected from the 6 ECS related receptors investigated. Cosinor analysis revealed circadian rhythms in many components in both sexes and lighting conditions. Next, we investigated the spatial localization of ECS components in the SCN with RNAscope <em>in situ</em> hybridization. Some genes, such as <em>Cnr1</em>, were more highly expressed in neurons with others, such as Fabp7, were elevated in astrocytes. <em>Cnr1</em> levels were highest in neurons that do not express the neuropeptides Avp or Vip, and lowest in Vip neurons. Our results support the idea that locally regulated ECS signaling through neuronal CB1 modulates circadian clock function.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"564 ","pages":"Pages 179-193"},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presynaptic ionotropic receptors in the cerebellar cortex: Just the tip of the iceberg?","authors":"F F Trigo, T Collin, I Llano, A Marty","doi":"10.1016/j.neuroscience.2024.11.040","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.040","url":null,"abstract":"<p><p>The presence of ionotropic receptors to neurotransmitters in presynaptic structures is well documented in many synapses of the mammalian brain. However, due to technical limitations, the actual prevalence of presynaptic ionotropic receptors, as well as their potential functional roles, have remained largely uncertain. The relatively simple and regular organization of neurites in the cerebellar cortex has offered a unique opportunity to bridge this gap of knowledge, by systematically probing the presence and role of presynaptic ionotropic receptors at various synapses. In the present review, we describe the collective results for glutamate and GABA presynaptic receptors in this brain region. They indicate a surprisingly large prevalence of presynaptic ionotropic receptors, with many synapses displaying several such receptors, often to both neurotransmitters. These results indicate that the presence of several types of presynaptic ionotropic receptors may be the rule rather than the exception in mammalian brain synapses. In addition, we discuss the functional roles of presynaptic ionotropic receptors in the induction of various forms of cerebellar long-term synaptic plasticity, as well as the potential consequences of having multiple presynaptic ionotropic receptors in a single synapse.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ascorbic acid on myelination in offspring of advanced maternal age.","authors":"Xinru Yan, Chunxue Jiang, Ziyao Han, Dishu Huang, Li Cheng, Wei Han, Li Jiang","doi":"10.1016/j.neuroscience.2024.11.019","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2024.11.019","url":null,"abstract":"<p><p>Myelination is the process by which oligodendrocytes ensheath axons to form myelin sheaths. Myelination is a crucial aspect of brain development and is closely associated with central nervous system abnormalities. However, previous studies have found that advanced maternal age might affect the myelination of offspring, potentially through the pathway of disrupting DNA methylation levels in the offspring's hippocampus. Current research has demonstrated that ascorbic acid can promote hydroxymethylation to reduce methylation levels in vivo. This study aims to verify the relationship between ascorbic acid and myelination, as well as the specific mechanism involved. Initially, oligodendrocyte differentiation was observed using immunofluorescence and Western blot. Myelination was assessed through Luxol Fast Blue staining, Glycine silver staining, immunofluorescence, and transmission electron microscopy. The demethylation level of oligodendrocyte progenitor cells was detected by immunofluorescence co-expression of OLIG2 and DNA hydroxylase ten-eleven translocation 1 (TET1), TET2, and TET3. Our study found that advanced maternal age could impair myelination in the hippocampus and corpus callosum of offspring. Ascorbic acid intervention may induce TET1 and TET2-mediated hydroxymethylation to ameliorate myelination disorders, promote myelination and maturation, and reverse the effects of advanced maternal age on offspring.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Charactertistics and neural mechanisms of trait and state empathy in deaf individuals","authors":"Xiangci Wu ,&nbsp;Huibin Jia ,&nbsp;Guifang He ,&nbsp;Xin Zhang ,&nbsp;Enguo Wang","doi":"10.1016/j.neuroscience.2024.11.047","DOIUrl":"10.1016/j.neuroscience.2024.11.047","url":null,"abstract":"<div><div>Empathy deficiencies are prevalent among deaf individuals. It has yet to be determined whether they exhibit deficiencies in both trait empathy and state empathy, along with the effect of top-down attention. Here, the current study employed the IRI-C scale and physiological pain empathy tasks (A-P task and A-N task) to explore the temporal dynamics of neural activities when deaf individuals were processing second-hand painful/non-painful stimuli. For trait empathy, we found that deaf individuals have deficiencies in both emotional and cognitive empathy compared to their hearing counterparts. For state empathy, we found that deaf individuals showed stronger automatic emotional empathy responses and paid more cognitive evaluation resources. Moreover, the differential processing of empathy between deaf individuals and hearing individuals towards others’ pain could be regulated by top-down attention, which occurs both in the early and late processing stages of pain empathy.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"565 ","pages":"Pages 19-28"},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intrinsic propagation directionality of fMRI infra-slow activity during visual tasks","authors":"Duho Sihn ,&nbsp;Junsuk Kim ,&nbsp;Myung Joon Kim ,&nbsp;Sung-Phil Kim","doi":"10.1016/j.neuroscience.2024.11.041","DOIUrl":"10.1016/j.neuroscience.2024.11.041","url":null,"abstract":"<div><div>The temporal order of propagation in the blood-oxygen-level-dependent (BOLD) infra-slow activity (ISA, 0.01–0.1 Hz) of functional magnetic resonance imaging (fMRI) can indicate the functional organization of the brain. While prior studies have revealed the temporal order of propagation of BOLD ISA during rest, how it emerges during cognitive tasks remains unclear. Furthermore, its differences between the gray and white matters at the whole-brain scale are unexplored. In this study, we probed the propagation of BOLD ISA using a publicly available fMRI dataset from participants performing visual detection and discrimination tasks (N = 46, 29 females). We examined the temporal order of propagation based on ISA oscillatory phase differences among brain parcels. During visual task performance, ISA in both the gray and white matters propagated in a direction from the visual cortex to the association cortex, including the default mode network (DMN). This result differs from the previously reported propagation direction during rest that traveled from the visual and somatosensory cortices to the DMN, suggesting that the functional organization may change when performing cognitive tasks. In addition, the propagation in the white matter represented more complex patterns than that in the gray matter, exhibiting that the cingulum preceded DMN. Our results may help the understanding of how task performance alters the sensory-DMN propagation according of ISA.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"564 ","pages":"Pages 52-59"},"PeriodicalIF":2.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in brain activation and connectivity during unaffected hand exercise in subacute and convalescent stroke patients","authors":"Yuqin Ma ,&nbsp;Dongyan Xie ,&nbsp;Yang Yu ,&nbsp;Kexin Yao ,&nbsp;Shuting Zhang ,&nbsp;Qiqi Li ,&nbsp;Yongfeng Hong ,&nbsp;Xianshan Shen","doi":"10.1016/j.neuroscience.2024.11.038","DOIUrl":"10.1016/j.neuroscience.2024.11.038","url":null,"abstract":"<div><div>Patients experiencing severe hemiplegia following a stroke struggle to rehabilitate their affected limbs. Cross-education (CE) training emerges as a promising rehabilitation method due to its safety, simplicity, low risk, and ability to effectively improve muscle strength in the affected limb. However, controversy surrounds the neural mechanisms and clinical applications of CE. To address this, we employed functional near-infrared spectroscopy to monitor the response of regions of interest (ROI) and functional connectivity in patients with stroke experiencing severe hemiplegia during one session of 50% maximal voluntary contraction (MVC) strength training with less-affected hand in both subacute and convalescent phases. Our objective was to compare the two stroke groups to gain insight into the potential utility for unilateral training of the less-affected limb as an effective rehabilitation approach during different phases post of stroke.</div><div>The findings revealed varying degrees of activation in the ROIs within the affected hemisphere across both groups during the task. Additionally, we found that the subacute stroke patients with severe hemiplegia (SPS) had higher blood oxygen levels in the ipsilesional primary motor (iM1), ipsilesional pre-motor and supplementary motor area (iP-SMA) and contralesional P-SMA (cP-SMA). Functional connectivity strength between the iM1 and contralesional brain regions, as well as between the iP-SMA and ipsilesional ROIs, showed statistically significant differences in SPS compared to convalescent stroke patients with severe hemiplegia (CPS) during a 50% MVC strength training session using the less-affected hand.</div></div><div><h3>Significance statement</h3><div>Exploring the neural mechanisms underlying one session of 50% MVC strength training with less-affected hand sheds light on a safe therapy. The study enhances our understanding of less-affected hand training and investigates the feasibility as a future rehabilitation approach. Analyzing how one session of 50% MVC strength training with less-affected hand affects brain activation and connectivity could lead to more tailored and effective rehabilitation strategies.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"565 ","pages":"Pages 10-18"},"PeriodicalIF":2.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Benzene, 1,2,4-Trimethoxy-5-(2-Methyl-1-Propen-1-yl) Attenuates D-galactose/AlCl3-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and improving Expression of Memory-Related Proteins” [Neuroscience 524 (2023) 242–255]","authors":"Peng Yang,&nbsp;Can Liao,&nbsp;Qinrui Hu,&nbsp;Jian Zhang,&nbsp;Huiyuan Yang,&nbsp;Shuze Xian,&nbsp;Shengjun Mao","doi":"10.1016/j.neuroscience.2024.11.015","DOIUrl":"10.1016/j.neuroscience.2024.11.015","url":null,"abstract":"","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"563 ","pages":"Pages 235-238"},"PeriodicalIF":2.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}