Neuroscience最新文献_第3页

The roles of TRPV1 receptors in nervous system with a special emphasis on sleep and memory.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-01 DOI: 10.1016/j.neuroscience.2024.11.080

Ming Fu, JunChao Zhu

引用次数: 0

Relationship between initial motor variability and learning and adaptive ability. A systematic review. 初始运动变异性与学习和适应能力之间的关系。系统综述。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-14 DOI: 10.1016/j.neuroscience.2024.10.052

Miguel López-Fernández, Rafael Sabido, Carla Caballero, Francisco J Moreno

{"title":"Relationship between initial motor variability and learning and adaptive ability. A systematic review.","authors":"Miguel López-Fernández, Rafael Sabido, Carla Caballero, Francisco J Moreno","doi":"10.1016/j.neuroscience.2024.10.052","DOIUrl":"10.1016/j.neuroscience.2024.10.052","url":null,"abstract":"Motor variability is an intrinsic feature of human beings that has been associated with the ability for learning and adaptation to specific tasks. The purpose of this review is to examine whether there is a possible direct relationship between individuals' initial variability in their ability for learning and adaptation in motor tasks. Eighteen articles examined the relationship between initial motor variability and the ability for learning or adaptation. Twelve found a direct relationship. In reward-based tasks, greater initial variability was associated with greater learning and adaption improvement when assessed using linear measures of dispersion, however, this association was not observed with temporal structure variability. While in error-based task associations were reported with both greater amount variability and more complexity temporal structure. Nevertheless, bias in initial performance related to the amount of variability was found, so the temporal structure of initial variability seems to be a better indicator of improvement in this type of task. Further research is needed for further research to better understand the potential relationship between initial motor variability and the ability for learning or adaptation in motor tasks.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"301-311"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negated actions are simulated within the primary motor cortex.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-12 DOI: 10.1016/j.neuroscience.2024.12.018

W Dupont, C Papaxanthis, L Lurquin, F Lebon, C Madden-Lombardi

{"title":"Negated actions are simulated within the primary motor cortex.","authors":"W Dupont, C Papaxanthis, L Lurquin, F Lebon, C Madden-Lombardi","doi":"10.1016/j.neuroscience.2024.12.018","DOIUrl":"10.1016/j.neuroscience.2024.12.018","url":null,"abstract":"Controversy persists regarding the representation of linguistically negated actions, specifically concerning activation and inhibitory mechanisms in the motor system, and whether negated action sentences evoke an initial motor simulation of the action to be negated. We conducted two experiments probing corticospinal excitability (CSE) and short-interval intracortical inhibition (SICI) in the primary motor cortex at different latencies while reading affirmative and negative action sentences. In experiment one, twenty-six participants read action and non-action sentences in affirmative or negative forms. Using transcranial magnetic stimulation, we probed CSE in hand muscles at rest and at several latencies after verb presentation. We observed a greater CSE for action sentences compared to non-action sentences, regardless of verb form. In experiment two, nineteen participants read affirmative and negative action sentences. We measured CSE and SICI at short and long latencies after verb presentation. CSE was greater for affirmative and negative action sentences at both latencies compared to rest. SICI did not change at the short latency but increased at longer latencies, regardless of verb form. Negated action sentences showed the same motor excitability as affirmed action sentences with no additional inhibition at early latencies. These results lend support for the idea that actions to be negated are initially simulated within the motor system. Neural differences between affirmative and negative action sentences may occur outside the primary motor cortex.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"468-478"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the peculiarities of cell types in the septum. 解密隔膜细胞类型的特殊性。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-26 DOI: 10.1016/j.neuroscience.2024.11.063

Michael Trojan, Dominik Kanigowski, Łukasz Bijoch, Martyna Pękała, Diana Legutko, Anna Beroun, Marek Bekisz, Luis V Colom, Sodikdjon A Kodirov

{"title":"Deciphering the peculiarities of cell types in the septum.","authors":"Michael Trojan, Dominik Kanigowski, Łukasz Bijoch, Martyna Pękała, Diana Legutko, Anna Beroun, Marek Bekisz, Luis V Colom, Sodikdjon A Kodirov","doi":"10.1016/j.neuroscience.2024.11.063","DOIUrl":"10.1016/j.neuroscience.2024.11.063","url":null,"abstract":"Similar to other brain regions, the neurons in the lateral septum (LS) are of heterogeneous populations. However, their resting membrane potential (RMP) on average is not too far apart. Cells were characterized based on biological markers by using brain slices, as under these in vitro conditions, neurons retain their morphologies. Since the LS neurons are not spontaneously excitable at RMP, the action potentials (APs) were evoked via injections of currents of moderate magnitude during the patch-clamp recordings. In coronal brain slices of rats, a smaller portion of neurons generated a train of APs of complex nature. In order to define the types of neurons with similar phenotypes, we subsequently used the four lines of td-Tomato transgenic mice. The brains of these mice express the promoter fluorophore td-Tomato and enhanced green fluorescent protein (eGFP). Therefore, recordings were conducted in a targeted manner in neurons expressing glutamic acid decarboxylase (GAD), parvalbumin (PV), somatostatin (SOM), or vasoactive intestinal polypeptide (VIP). Similar spike phenotypes that we refer to as type III, in order to distinguish from AP in principal cells - type I and those in interneurons - type II, also exist in mice, substantiating a similitude among rodents. The type III AP is selectively triggered by Ca2+ in GAD and SOM-positive neurons. Conclusions are supported by established pharmacologic tools, nimodipine, TTX, and ZD7288, a selective HCN channel antagonist.Collectively, these observations revitalize our knowledge from pioneering studies with regard to the brain of mammals in general and septal structures in particular.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"327-341"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proprioceptive acuity for locating and controlling movements of a hand-held tool. 定位和控制手持工具移动的直觉敏锐度。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-26 DOI: 10.1016/j.neuroscience.2024.11.048

Warren G Darling, Bennett I Zuck

{"title":"Proprioceptive acuity for locating and controlling movements of a hand-held tool.","authors":"Warren G Darling, Bennett I Zuck","doi":"10.1016/j.neuroscience.2024.11.048","DOIUrl":"10.1016/j.neuroscience.2024.11.048","url":null,"abstract":"We investigated proprioceptive acuity for location and motion of a never seen hand-held tool (30 cm long rod) and the accuracy of movements to place tool parts in the location of remembered visual targets. Ten blindfolded right-handed subjects (5 females) reached with the tool held in the right hand to touch the tip and midpoint to the stationary and moving left index-tip, to the right and left ear lobes and to remembered visual target locations. We also tested accuracy of left hand rod reaches to the ear lobes to determine if rod dimensions and control of tool movements experienced during right hand tool use could be used to accurately localize the rod parts when held in the left hand. Errors for right hand-held rod-tip movements to touch the stationary and moving left index-tip averaged only about 1 cm larger than observed previously for right hand movements to touch its index-tip to the left index-tip. The tool-tip was localized with lower mean distance errors (about 1 cm) than the tool-midpoint (5.5-6.5 cm) when reaching to touch the ear lobes with the rod in right and left hands. Right hand reaches to place the tool- tip and midpoint in remembered visual target locations were inaccurate with large overshoots of close targets and undershoots of far targets, similar to previous reports for reaching with the right hand to remembered visual targets. These results support the distalization hypothesis, that the tool endpoint becomes the effective upper limb endpoint when using the tool.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"211-221"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of microglia with the microenvironment in spinal cord injury.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-30 DOI: 10.1016/j.neuroscience.2024.11.074

A V Timofeeva, E R Akhmetzyanova, A A Rizvanov, Y O Mukhamedshina

{"title":"Interaction of microglia with the microenvironment in spinal cord injury.","authors":"A V Timofeeva, E R Akhmetzyanova, A A Rizvanov, Y O Mukhamedshina","doi":"10.1016/j.neuroscience.2024.11.074","DOIUrl":"10.1016/j.neuroscience.2024.11.074","url":null,"abstract":"This article discusses the peculiarities of microglia behaviour and their interaction with other cells of the central nervous system (CNS) during neural tissue injury with a focus on spinal cord injury (SCI). Taking into account the plasticity of microglia, the influence of the microenvironment should be taken into account to establish the mechanisms determining the polarization pathways of these cells. Determination of the system of microglia interactions with other CNS cells during injury will reveal the patterns of post-traumatic microglia responses, in particular, determining both pro-inflammatory and anti-inflammatory responses. This review compiles information on changes in microglia activation, migration and phagocytosis, as well as their reciprocal effects on other CNS cells, such as neurons, astrocytes and oligodendrocytes, in the background of SCI. The information contained in this article may be of interest not only to scientists studying traumatic injuries of the central nervous system, but also to specialists in the field of studying and treating neurodegenerative diseases, since the mechanisms occurring in the injured spinal cord may also be characteristic of pathological events in degenerative processes.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"594-603"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitric oxide synthase system in the brain development of neonatal hypothyroid rats. 新生甲状腺功能减退大鼠大脑发育过程中的一氧化氮合酶系统

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-10-24 DOI: 10.1016/j.neuroscience.2024.10.040

Juan Carlos López-Ramos, Esther Martínez-Lara, Julia Serrano, Patricia Fernández, Gloria G Parras, Antonio Ruiz-Marcos, José Rodrigo

{"title":"Nitric oxide synthase system in the brain development of neonatal hypothyroid rats.","authors":"Juan Carlos López-Ramos, Esther Martínez-Lara, Julia Serrano, Patricia Fernández, Gloria G Parras, Antonio Ruiz-Marcos, José Rodrigo","doi":"10.1016/j.neuroscience.2024.10.040","DOIUrl":"10.1016/j.neuroscience.2024.10.040","url":null,"abstract":"Thyroid hormones play an important morphogenetic role during the fetal and neonatal periods and regulate numerous metabolic processes. In the central nervous system, they control myelination and overall brain development, regional gene expression, and regulation of oxygen consumption. Their deficiency in the fetal and neonatal periods causes severe mental retardation, due to lack of thyroid function, or to iodine deficiency. At the same time, nitric oxide is an atypical neurotransmitter that also has special relevance in neuronal development and plasticity and functions as a vasodilator, regulating cerebral blood flow. Although under physiological conditions it functions as a neuroprotector, in excess it can be neurotoxic. We have studied, by immunocytochemical and Western blot techniques, the evolution of the expression of neuronal and inducible isoforms of the enzyme nitric oxide synthase, and of nitrotyrosine as a marker of protein nitration produced by the presence of nitric oxide, during the early stages of postnatal brain development. We induced hypothyroidism by administering mercaptomethylimidazole to pregnant mothers, from the seventh day of gestation until the sacrifice of the offspring. The results show a delay in the evolution of the expression of the two isoforms of the enzyme nitric oxide synthase in hypothyroid animals, followed by an anomalous overexpression in later stages. Finally, the expression of nitrotyrosine follows an evolution that is synchronized with that shown by both isoenzymes in control and hypothyroid animals.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"155-171"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electromagnetic brain waves do not convincingly support Cartesian dualism - Comment to Ambron.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-15 DOI: 10.1016/j.neuroscience.2024.12.026

Peter Zhong-Yi Sun

引用次数: 0

Pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane exposure in neonatal rats. 四甲基吡嗪的预处理减轻了七氟醚暴露对新生大鼠学习和记忆的损害。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-11-13 DOI: 10.1016/j.neuroscience.2024.11.013

Kui Wang, Haidong Wei, Liufei Yang, Shuyue Zhang, Yiqin Cheng, Chen Li, Pengyu Jia, Yuanyuan Zhang, Yan Zhang, Pei Fan, Ning Wang, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhang

{"title":"Pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane exposure in neonatal rats.","authors":"Kui Wang, Haidong Wei, Liufei Yang, Shuyue Zhang, Yiqin Cheng, Chen Li, Pengyu Jia, Yuanyuan Zhang, Yan Zhang, Pei Fan, Ning Wang, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhang","doi":"10.1016/j.neuroscience.2024.11.013","DOIUrl":"10.1016/j.neuroscience.2024.11.013","url":null,"abstract":"Sevoflurane impairs learning and memory of the developing brain. However, strategies to mitigate these detrimental effects have been scarce. Herein, we investigated whether tetramethylpyrazine pretreatment could alleviate the impairment of learning and memory and its underlying mechanism in sevoflurane-exposed neonatal rats. Postnatal 7-day Sprague-Dawley (SD) rats or primary hippocampal neurons were pretreated with tetramethylpyrazine and then exposed to sevoflurane. The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and lactate dehydrogenase (LDH) assays were used to detect neuronal injury. Learning and memory function were evaluated by novel object recognition and Morris water maze tests. Long-term potentiation (LTP) was recorded to evaluate synaptic plasticity electrophysiologically in the hippocampal slices. Golgi-Cox staining or PSD95 immunochemistry was used to detect the morphology of dendritic spines. Western blotting was employed to assess the expressions of cleaved Caspase-3, PSD95, N-methyl-D-aspartate receptor (NMDAR) subunits NMDAR1, NMDAR2A and NMDAR2B in the hippocampus or cultured neurons. It was found that neonatal exposure of sevoflurane impaired learning and memory, increased neuronal apoptosis, altered the morphology of dendritic spines, upregulated the expressions of NMDAR2A and PSD95, and induced LTP deficits. Pretreatment with tetramethylpyrazine not only alleviated impairment of learning and memory, but also improved sevoflurane-induced changes in neuronal damage, dendritic spine morphology, NMDAR2A and PSD95 expressions, as well as LTP. These findings indicated that pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane through improvement of hippocampal synaptic plasticity in neonatal rats.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"457-467"},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern Regarding "Expression of pannexin2 protein in healthy and ischemized brain of adult rats" [Neuroscience 148 (2007) 653-667].

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-04 DOI: 10.1016/j.neuroscience.2024.11.016

A Zappalà, G Li Volti, M F Serapide, R Pellitteri, M Falchi, F La Delia, V Cicirata, F Cicirata

引用次数: 0