Neuroscience最新文献

{"title":"Comparisons of metabolites and gut microbiota profiles for both young and middle-aged APPSwe/PS1De9 mice","authors":"Guiping Wang ,&nbsp;Tongtong Ma ,&nbsp;Ruitong Liu ,&nbsp;Huiwen Gu ,&nbsp;Zheng-Yu Zhou ,&nbsp;Zhongxiao Wan","doi":"10.1016/j.neuroscience.2025.04.053","DOIUrl":"10.1016/j.neuroscience.2025.04.053","url":null,"abstract":"<div><div>The research focused on exploring the differences and relationships between gut microbiota and metabolites at various stages of Alzheimer’s disease (AD), specifically using APP/PS1 mice at the ages of 6 months and 10 months. To assess metabolites in serum and cortex, and to evaluate gut microbiota profiles in cecal content, UPLC-MS/MS and 16S rRNA sequencing techniques were utilized, respectively. Findings indicated that, in comparison to younger mice, serum concentrations of L-Leucine, thymine, and Glucosamine 6-phosphate were lower, whereas levels of Sorbitol and Palmitic acid were higher. Furthermore, measurements of the ACE and Chao1 indices significantly declined in the older cohort. At the phylum level, the relative abundance of Bacteroidetes showed a decline, while there was an increase in Actinobacteria and TM7 bacteria among the middle-aged subjects. The novelty of this study is we found there were notable alterations in both gut microbiota and metabolites within serum and cortex when comparing young and older APP/PS1 mice, emphasizing the important connections between metabolites and gut microbiota throughout the progression of AD. These results indicate that manipulating metabolites and gut flora may serve as a vital strategy for the prevention and management of AD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 54-63"},"PeriodicalIF":2.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical implicit procedural learning of adults with developmental coordination disorder: Evidence involving the modulation of cortical power","authors":"Yulan Yao ,&nbsp;Zuyang Fan ,&nbsp;Wenchong Du ,&nbsp;Ying Liu ,&nbsp;Yuqin Deng ,&nbsp;Binn Zhang","doi":"10.1016/j.neuroscience.2025.04.052","DOIUrl":"10.1016/j.neuroscience.2025.04.052","url":null,"abstract":"<div><div>This study aimed to explore the implicit procedural learning and associated neural oscillatory activities in adults with Developmental Coordination Disorder (DCD) using electroencephalography (EEG). The sample consisted of 22 adults with DCD (14 females) and 22 age-matched controls (11 females), aged 18–21 years. Participants engaged in a modified Serial Reaction Time Task (SRTT) designed to assess implicit sequence learning. Behavioral results did not show significant differences in reaction times or speed-accuracy trade-off indices between the DCD and control groups, suggesting that implicit sequence learning might not be impaired in adults with DCD. However, EEG analysis revealed marked differences in theta oscillation energies; notably, the DCD group displayed higher theta amplitudes in the frontal region and delayed peaks in frontal-region theta bands compared to controls. These findings suggest that while behavioral performance might appear typical, the underlying neural processes in the DCD group are significantly different and underscore procedural learning deficits in adults with DCD. The results enrich our understanding of the neural underpinnings of DCD and offer insights for devising targeted interventions to improve procedural learning abilities in affected individuals.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 37-46"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum","authors":"Hamide Nasiri ,&nbsp;Ali Azargoonjahromi ,&nbsp;Zahra Nouri ,&nbsp;Sayed Mehrdad Azimi ,&nbsp;Hossein Zand ,&nbsp;Amir Shourideh ,&nbsp;Soudabeh Heydari ,&nbsp;Behnaz Mahmoudvand ,&nbsp;Somayeh Barabadi ,&nbsp;Nastaran Samadpour ,&nbsp;Alireza Mohamadhosseini ,&nbsp;Amirhossein Khodadadi ,&nbsp;Shayan Shakeri ,&nbsp;Mahsa Mayeli ,&nbsp;For the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neuroscience.2025.05.013","DOIUrl":"10.1016/j.neuroscience.2025.05.013","url":null,"abstract":"<div><div>Leucine, a branched-chain amino acid (BCAA), exhibits paradoxical effects in Alzheimer’s disease (AD), demonstrating both neuroprotective and neurotoxic roles. While prior studies have investigated leucine’s systemic and metabolic impacts, its influence on brain structure remains unexplored. This study aimed to fill this critical gap by examining the relationship between serum leucine levels, brain volume metrics, and cognitive performance in individuals across the AD continuum.</div><div>Serum leucine concentrations were quantified using the Nightingale Health nuclear magnetic resonance (NMR) platform. Cognitive performance was assessed using the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog 11 and 13), and structural brain volumes, including total cerebrum, cerebrum gray matter, and total brain gray matter, were derived from T1-weighted magnetic resonance imaging (MRI) via automated segmentation. Mediation analysis was employed to determine whether changes in brain volume mediate the association between serum leucine levels and cognitive performance.</div><div>Elevated serum leucine levels were significantly associated with reduced total cerebrum volume, cerebrum gray matter volume, and total brain gray matter volume. Furthermore, mediation analysis revealed that these reductions in brain volume partially mediated the relationship between higher leucine levels and poorer cognitive outcomes.</div><div>These findings provide evidence linking elevated leucine levels to brain atrophy and cognitive decline in AD, suggesting a potentially deleterious role of leucine in neurodegeneration. This highlights the importance of further mechanistic investigations to clarify leucine’s role in AD pathology and assess its viability as a therapeutic target.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 47-53"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural investigations of a digital-game based intervention for young Learners with mathematical developmental variability","authors":"Fengjuan Wang ,&nbsp;Azilawati Jamaludin","doi":"10.1016/j.neuroscience.2025.05.001","DOIUrl":"10.1016/j.neuroscience.2025.05.001","url":null,"abstract":"<div><div>Developmental dyscalculia (DD), a significant mathematics learning difficulty, remains under-researched in terms of its neural mechanisms and effective interventions. Few studies have examined neural changes after math interventions in young children. This study investigated these changes in thirty-two dyscalculia-at-risk (DR) and non-dyscalculia-at-risk (NDR) children following a digital game-based intervention, focusing on brain activation and network changes using graph theory metrics. NDR children were randomized into intervention and control groups. Results indicated increased activation in the inferior frontal gyrus (IFG) and intraparietal sulcus (IPS) during symbolic arithmetic tasks for both DR and NDR groups post-intervention. Conversely, both groups showed decreased IFG activation during nonsymbolic tasks. Notably, IPS activation significantly increased only for the NDR intervention group in symbolic tasks, a finding that disappeared when controlling for Total Reading, suggesting the potential influence of initial reading ability on intervention outcomes. Brain network analysis showed improved integration for the NDR intervention group, demonstrated by higher clustering coefficient and local efficiency. The DR group, however, displayed reduced local efficiency, potentially reflecting shifts in network states, or insufficient intervention dosage.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 272-281"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-specific neural responses to SMA and M1 stimulation during implicit motor sequence learning: Insights from a concurrent tDCS-fNIRS approach","authors":"Jessie Siew-Pin Leuk ,&nbsp;Tommy Hock-Beng Ng ,&nbsp;Alicia Marie Goodwill ,&nbsp;Wei-Peng Teo","doi":"10.1016/j.neuroscience.2025.05.002","DOIUrl":"10.1016/j.neuroscience.2025.05.002","url":null,"abstract":"<div><div>Implicit Motor Sequence Learning (IMSL) is critical for automating motor skills, yet it declines with age, impacting independence and quality of life. This study investigated the age-specific roles of the primary motor cortex (M1) and supplementary motor area (SMA) in IMSL using a novel concurrent transcranial direct current stimulation (tDCS) and functional near-infrared spectroscopy (fNIRS) approach. Twenty younger adults (21–32 years old [M = 24.3 ± 3.26]) and twenty older adults (60–76 years old [M = 67.5 ± 4.88]) performed a Serial Reaction Time Task (SRTT) in three cross-over, counterbalanced sessions with anodal tDCS targeting: i) SMA_Left, ii) M1_Left, or iii) sham stimulation during task. Neural activity and connectivity were measured pre-, during-, and post-stimulation using a 20-channel fNIRS, covering prefrontal, premotor, and motor regions. Results revealed significant age-related differences in SRTT performance, with older adults consistently performing poorer despite practice-driven improvements in both groups. While tDCS did not enhance motor learning behaviourally, distinct neural effects emerged, demonstrating age-specific modulation. In older adults, M1 stimulation elicited task- dependent, asymmetric O₂Hb changes in the premotor area (PMA): decreased PMA_Right activity during sequence blocks and increased activity during random blocks, with opposite patterns in PMA_Left. SMA stimulation normalised weak PMA_Left-prefrontal connectivity in older adults, whereas younger adults showed strengthened connectivity between PMA_Right- PFC_Right and PFC_Left-PFC_Right, reflecting its role in spatial integration and motor planning. These findings advance the understanding of IMSL-related neuroplasticity, highlighting the importance of optimising tDCS protocols to support motor learning in ageing population.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 240-251"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the thermoregulatory mechanism – Raising the possibility that it is acquired at birth","authors":"Yong Yu ,&nbsp;Yoshihisa Koyama ,&nbsp;Shoichi Shimada","doi":"10.1016/j.neuroscience.2025.04.044","DOIUrl":"10.1016/j.neuroscience.2025.04.044","url":null,"abstract":"<div><div>Whether the human thermoregulation mechanism in response to environmental temperature stimuli originates from learning or evolution remains an intriguing research question. Body temperature regulation depends not only on innate temperature sensation but also on acquired conditioning. Maintaining body temperature is essential for homeostasis, and the brain coordinates this process through a network of interconnected regulatory systems. In this review, we discuss how humans perceive temperature and establish thermoregulatory mechanisms at birth. We also propose an acquired connectivity structure perspective for the development of neonatal thermoregulatory mechanisms, particularly for brown adipose tissue thermogenesis. This perspective will enhance our understanding of the various acquired mechanisms of thermoregulation and adaptation to environmental temperature. Ultimately, this knowledge may contribute to the development of effective interventions for thermal balance disruptions, such as neonatal hypothermia.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 123-131"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in cognitive function and functional brain networks in chemotherapy-exposed patients with breast cancer: A longitudinal study","authors":"Wi Hoon Jung ,&nbsp;Mison Chun ,&nbsp;Nam Hee Kim","doi":"10.1016/j.neuroscience.2025.05.010","DOIUrl":"10.1016/j.neuroscience.2025.05.010","url":null,"abstract":"<div><div>Despite the accumulating evidence on cognitive impairment in patients with cancer after chemotherapy, it remains unclear whether changes in cognitive function after chemotherapy are related to changes in brain function, because most of the previous studies were cross-sectional. Additionally, little is known regarding changes in functional brain network topological measurements (which quantify different features of brain network organization) after chemotherapy. Therefore, by applying graph theoretical analysis to resting-state functional magnetic resonance imaging data in a longitudinal study design, we investigated whether patients with breast cancer (n = 17) had changes in cognitive function and in topological properties of the functional brain network before and after chemotherapy (particularly within 6 months to 1 year after chemotherapy) and whether these changes were correlated. Patients exhibited a higher cognitive function (visual and spatial memory) and some network topological properties at a certain sparsity threshold after treatment, showing better memory function, network segregation, and small-worldness. We also observed a correlation between changes in the observed cognitive functions and network topological properties. These novel findings improve our understanding of the long-term effects of chemotherapy on cognitive function and functional brain network in patients with breast cancer, revealing part of the trajectories of changes after chemotherapy. Furthermore, these findings provide insights into cognitive and neural recovery and the associated neural mechanisms of network topological properties.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 1-9"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of Cav3.2 calcium channels in autism-like cognitive behavior induced by prenatal valproic acid exposure","authors":"Flavia T.T. Antunes,&nbsp;Gerald W. Zamponi","doi":"10.1016/j.neuroscience.2025.05.011","DOIUrl":"10.1016/j.neuroscience.2025.05.011","url":null,"abstract":"<div><div>Recent findings indicated that <em>CACNA1H</em> mutations may contribute to Autism Spectrum Disorder (ASD) by reducing Cav3.2 activity, disrupting neuronal function, and brain development. To explore how Cav3.2 deficiency affects autism-related cognition, we induced autism-like behaviors in wild-type (WT) and Cav3.2 knockout mice (KO) using the prenatal valproic acid model (pre-VPA). We analyzed how cognitive behavior (repetitive behavior, spatial working memory, sociability, social preference, and anxiety) in this model is differentially impacted in WT and Cav3.2 KO mice of different sexes and ages. In WT mice, pre-VPA increased repetitive behavior and self-grooming (&gt;75 %). In contrast, there was no pre-VPA-induced increase in repetitive behavior in Cav3.2 KO male mice, and there was a reduction in self-grooming in adult KO females (∼40 %). While pre-VPA impaired spatial working memory in wild-type adult mice of both sexes, Cav3.2 KO mice were protected. Pre-VPA also induced sociability and social preference deficits in WT mice of both sexes. Deletion of Cav3.2 rescued sociability deficits in juvenile and adult male but not female mice. In addition, Cav3.2 channels appeared to contribute to social preference impairment in juvenile male KO mice and both sexes in adulthood. Additionally, KO mice exposed to pre-VPA exhibited lower anxiety levels in the elevated plus maze test when compared to KO controls. Together, our results provide new insights into the role of Cav3.2 channels in ASD-related behavior and suggest that these channels contribute to a range of behavioral deficits.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 71-79"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond lipid management: Clofibrate’s anti-neuroinflammation role via NF-κB inhibition in ischemic stroke","authors":"Jiaxin Sun ,&nbsp;Guolei Liao ,&nbsp;Ping Wang ,&nbsp;Jingyuan Zhang ,&nbsp;Hongling Jing ,&nbsp;Feng Lin ,&nbsp;Yuhang Wang ,&nbsp;Xinying Chen ,&nbsp;Lei Zhang ,&nbsp;Wenli Chen","doi":"10.1016/j.neuroscience.2025.05.009","DOIUrl":"10.1016/j.neuroscience.2025.05.009","url":null,"abstract":"<div><div>Ischemic stroke(IS) is the second leading cause of mortality and disability worldwide and neuroimmunity plays an important role in its occurrence and development. The pathogenesis of IS is associated with various metabolic disorders. Yet reports on the amelioration of neuroinflammation by modulating metabolic disorders in clinical practice are scarce. By screening drugs targeting the inflammatory cytokine pro IL-1β in the metabolism-related compound library, we first found that clofibrate, an antihyperlipidemic drug, has an anti-neuroinflammatory effect. However, the role of clofibrate in exerting anti-inflammatory effects in IS and its underlying mechanisms remain unclear. To further investigate the role of clofibrate, we administered clofibrate in an LPS-stimulated microglial cell model and in mice with transient middle cerebral artery occlusion. Notably, clofibrate lowered IL-1β expression, both in vivo and in vitro. Simultaneously, clofibrate reduced infarct volume after ischemia and reperfusion. Moreover, clofibrate affected IS by regulating the expression of NF-κB p65 and NLRP3, thus suppressing the expression of inflammatory factors. These findings suggest that clofibrate could be a prospective medication to alleviate neuroinflammation in IS.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 144-153"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"African leadership in brain diplomacy: The Yaoundé declaration advances the global brain economy playbook for better brain health","authors":"Alfred Kongnyu Njamnshi ,&nbsp;Jacques Fame Ndongo ,&nbsp;Ferdinand Ngoh Ngoh ,&nbsp;Lejeune Mbella Mbella ,&nbsp;Paul M. Ghogomu ,&nbsp;Séraphin M. Fouda ,&nbsp;Marie-Thérèse A. Ondoa Obama ,&nbsp;Madeleine Tchuinte ,&nbsp;Alamine Ousmane Mey ,&nbsp;Malachie Manaouda ,&nbsp;Joseph Beti Assomo ,&nbsp;René E. Sadi ,&nbsp;Louis-Paul Motaze ,&nbsp;Emmanuel Nganou Djoumessi ,&nbsp;Minette Libom Li Likeng ,&nbsp;Pauline E. Nalova Lyonga ,&nbsp;Laurent S. Etoundi Ngoa ,&nbsp;Mounouna Foutsou ,&nbsp;Narcisse Mouelle Kombi ,&nbsp;Bakary Issa Tchiroma ,&nbsp;Harris A. Eyre","doi":"10.1016/j.neuroscience.2025.04.032","DOIUrl":"10.1016/j.neuroscience.2025.04.032","url":null,"abstract":"<div><div>Africa, the world’s second-largest continent is home to 1.5 billion people, accounting for nearly 20% of the global population, (60% under age 25). By 2050, Africa’s population will be 2.5 billion, and by 2035, <span><span>more young Africans will be entering the workforce each year</span><svg><path></path></svg></span> than in the rest of the world combined. Africa also hosts a rich social, cultural, and geopolitical diversity across its 5 geopolitical zones covering 54 countries. It is the most genetically, culturally, and linguistically diverse region on the planet. However, Africa’s contribution to the global economy could be more significant if it urgently embraces the brain economy and leads in the development of new methodologies and approaches which can be exported around the world.</div><div>In this paper, we explain our strategy to advance the Yaoundé Declaration for the Brain Economy, Brain Health, and Brain Capital. The Declaration has been endorsed by Cameroon’s President, His Excellency Paul Biya, and demonstrates African leadership in global brain and society innovations, laying out a roadmap for how Africa can outcompete other economies by deftly deploying brain science-inspired policies and investments. We outline a new economic approach for African jobs, economic growth, sustainability, resilience, health, and well-being.</div><div>The brain economy offers a broader framework than the current sustainable development goals (SDG) agenda. The Yaoundé Declaration is <em>trans</em>-disciplinary and cross-cutting across sectors: 32 sitting members of government from different sectors having co-authored this paper. It aligns with many aspects of the <span><span>United Nations Pact for the Future</span><svg><path></path></svg></span> and can accelerate the SDG.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"577 ","pages":"Pages 161-174"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}