Neuroscience最新文献_第4页

BrainTract: segmentation of white matter fiber tractography and analysis of structural connectivity using hybrid convolutional neural network 脑道：脑白质纤维束分割及混合卷积神经网络结构连通性分析。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.043

Puranam Revanth Kumar , B Shilpa , Rajesh Kumar Jha

{"title":"BrainTract: segmentation of white matter fiber tractography and analysis of structural connectivity using hybrid convolutional neural network","authors":"Puranam Revanth Kumar , B Shilpa , Rajesh Kumar Jha","doi":"10.1016/j.neuroscience.2025.06.043","DOIUrl":"10.1016/j.neuroscience.2025.06.043","url":null,"abstract":"<div><div>Tractography uses diffusion Magnetic Resonance Imaging (dMRI) to noninvasively reconstruct brain white matter (WM) tracts, with Convolutional Neural Network (CNNs) like U-Net significantly advancing accuracy in medical image segmentation. This work proposes a metaheuristic optimization algorithm-based CNN architecture. This architecture combines the Inception-ResNet-V2 module and the densely connecting convolutional module (DI) into the Spatial Attention U-Net (SAU-Net) architecture for segmenting WM fiber tracts and analyzing the brain’s structural connectivity. The proposed network model (DISAU-Net) consists of the following parts are; First, the Inception-ResNet-V2 block is used to replace the standard convolutional layers and expand the network’s width; Second, the Dense-Inception block is used to extract features and deepen the network without the need for any additional parameters; Third, the down-sampling block is used to speed up training by decreasing the size of feature maps, and the up-sampling block is used to increase the maps’ resolution. In addition, the parameter existing in the classifiers is randomly selected with the Gray Wolf Optimization (GWO) technique to boost the performance of the CNN architecture. We validated our method by segmenting WM tracts on dMRI scans of 280 subjects from the human connectome project (HCP) database. The proposed method is far more efficient than current methods. It offers unprecedented quantitative evaluation with high tract segmentation consistency, achieving accuracy of 97.10%, dice score of 96.88%, recall 95.74%, f1-score 94.79% for fiber tracts. The results showed that the proposed method is a potential approach for segmenting WM fiber tracts and analyzing the brain’s structural connectivity.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 218-230"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BACE1 and endogenous Aβ: novel PRP complex in environment enrichment mediated behavioral tagging BACE1和内源性Aβ：新的PRP复合物在环境富集介导的行为标记。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.041

Medha Kaushik , Sharon Jacob , Pinky , Ahmed Shaney Rehman , Hiba Khan , Pooja Kaushik , Shiv Dutt Joshi , Suhel Parvez

{"title":"BACE1 and endogenous Aβ: novel PRP complex in environment enrichment mediated behavioral tagging","authors":"Medha Kaushik , Sharon Jacob , Pinky , Ahmed Shaney Rehman , Hiba Khan , Pooja Kaushik , Shiv Dutt Joshi , Suhel Parvez","doi":"10.1016/j.neuroscience.2025.06.041","DOIUrl":"10.1016/j.neuroscience.2025.06.041","url":null,"abstract":"<div><div>Behavioral Tagging (BT) is a well-established phenomenon under <em>in vivo</em> conditions to understand molecular framework of long-term memory (LTM) consolidation. BT has been extensively explored using different learning tasks and novelties at the behavioral level, while at the molecular level, handful of plasticity related proteins (PRPs) such as PKMζ, CREB, BDNF have been explored in various manners thereof. Hence, the quest for novel PRPs in BT becomes a necessity, since repeated studies of known PRPs results in scientific stagnation and cessation of further exploration. Emerging literature suggests potential role of BACE1 and endogenous Aβ in maintenance of synaptic plasticity and long-term potentiation. The present study aims to characterize the effects of BACE1 inhibition using minocycline on novel object recognition (NOR) LTM through environment enrichment (EE) mediated BT. BACE1 is responsible for endogenous Aβ generation, hence its inhibition also subdues the Aβ synthesis. Our results significantly demonstrate the active involvement of BACE1 and endogenous Aβ in facilitating NOR-LTM consolidation through EE mediated BT for the first time under <em>in vivo</em> conditions. Interestingly, EE exposure was found to induce the synthesis of BACE1 and endogenous Aβ in BT paradigm along with their potential interplay with PKMζ signaling to facilitate NOR-LTM consolidation. Taken together, our results provide first hand evidence of the role of BACE1 and endogenous Aβ as novel PRP complex in EE mediated BT phenomenon. The results provide significant advance in our understanding of LTM consolidation process and paves the way for exploration of novel molecular pathways involved in the process.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 238-248"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Task-state EEG feature extraction for spatial cognition analysis: a power spectral density and permutation conditional mutual information approach. 用于空间认知分析的任务状态脑电图特征提取：功率谱密度和排列条件互信息方法。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.036

Yijun Liu, Mohd Shafie Bin Mustafa, MIqbal Bin Saripan, Muhammad Rezal Bin Kamel Ariffin, Xianglong Wan, Xianling Dong, Xifa Lan, Dong Wen

{"title":"Task-state EEG feature extraction for spatial cognition analysis: a power spectral density and permutation conditional mutual information approach.","authors":"Yijun Liu, Mohd Shafie Bin Mustafa, MIqbal Bin Saripan, Muhammad Rezal Bin Kamel Ariffin, Xianglong Wan, Xianling Dong, Xifa Lan, Dong Wen","doi":"10.1016/j.neuroscience.2025.06.036","DOIUrl":"10.1016/j.neuroscience.2025.06.036","url":null,"abstract":"<p><p>The permutation conditional mutual information (PCMI) method which combined time and spatial domain information was found effective in analyzing EEG signals of neuron groups. Considering the absence of frequency domain information in the PCMI algorithm, a feature extraction method based on Power Spectral Density Permutation Conditional Mutual Information (PSDPCMI) was first proposed to analyze task-state EEG signals. In this study, the performance of the PSDPCMI algorithm was employed for a VR spatial cognitive training experiment based on a Virtual Community training game and a Virtual City Walking testing game as carriers for subjects' training and evaluation. The PSD, PCMI, and PSDPLV feature extraction methods were compared with the proposed PSDPCMI algorithm. According to the results, the highest classification accuracy was achieved across all frequency bands, with notable performance in the Theta, Beta2, and Gamma frequency bands. Besides, the new algorithm proposed also had higher precision, recall, F1-score, and AUC-score than the PSD, PCMI, and PSDPLV algorithms in most frequency bands and performed well in the classification accuracy of different classification models and another spatial cognitive dataset. The experimental outcomes demonstrated that the proposed PSDPCMI method in feature extraction showed a significant performance for the EEG signal analysis.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the etiology of metallic taste during head and neck cancer treatments: a study of facial and glossopharyngeal nerve interactions 头颈癌治疗期间金属味的病因评估：面部和舌咽神经相互作用的研究

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.038

Guillaume Buiret , Hélène Brignot , Chantal Septier , Gilles Feron , Thierry Thomas-Danguin

{"title":"Evaluating the etiology of metallic taste during head and neck cancer treatments: a study of facial and glossopharyngeal nerve interactions","authors":"Guillaume Buiret , Hélène Brignot , Chantal Septier , Gilles Feron , Thierry Thomas-Danguin","doi":"10.1016/j.neuroscience.2025.06.038","DOIUrl":"10.1016/j.neuroscience.2025.06.038","url":null,"abstract":"<div><div>Metallic Taste (MT) is frequently described during head and neck cancer treatments but very little is known about its etiologies. One hypothesis to explain the MT is the removal of facial nerve inhibition on the glossopharyngeal nerve. Indeed, the decrease of taste afferents mediated by the facial nerve (anterior two-thirds of the tongue) due to cancer or its treatments, would reveal those mediated by the glossopharyngeal nerve (posterior one-third of the tongue) and thus lead to MT perception. The aim of this study was to evaluate the validity of this hypothesis. Selective supraliminar taste tests on the tip and the base of the tongue were regularly performed on 44 patients with head and neck cancers before, during, and after their treatment. Sweet, salty, bitter, sour, and MT were tested. Patients were grouped based on whether they reported experiencing MT or not. Twelve patients complained about MT (27.2 %), always during the treatment phase. Most of them (83.3 %) were treated by surgery and radiotherapy or radiochemotherapy. Supraliminar tastes were altered in every patient, especially during the treatment phase. Test results showed that perceived intensity was significantly reduced in patients reporting MT for salt, sweet and sour. This was observed more on the base of tongue than on the tip of the tongue. MT was significantly linked with mucositis (p = 0.027) but with neither candidiasis (p = 0.38) nor salivary flow (p = 0.63). The hypothesis of removal of facial nerve inhibition on the glossopharyngeal nerve cannot explain MT in head and neck cancer.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 80-87"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Blood-Brain barrier in bacterial translocation 血脑屏障在细菌易位中的作用。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.037

Abdullahi Tunde Aborode , Ridwan Olamilekan Adesola , Godfred Yawson Scott , Victor Abiola Adepoju , Otobong Donald Akan , Adedeji Ogunyemi , Awoyemi Praise-God Adetunji , Femi Qudus Arogundade , Daniel Kwaku Somuah , Addo Osei Emmanuel , Blessing Ameh , Ifedayo Samuel Oluwaseun , Anthony Ifeanyi Osu , Victor Chukwuebuka Jonathan , Chibuzor Stella Amadi , Modupe V. Oladayo , Awah Favour Matthew , Isreal Ayobami Onifade , Sodiq Fakorede , Adetolase Azizat Bakre

{"title":"Role of Blood-Brain barrier in bacterial translocation","authors":"Abdullahi Tunde Aborode , Ridwan Olamilekan Adesola , Godfred Yawson Scott , Victor Abiola Adepoju , Otobong Donald Akan , Adedeji Ogunyemi , Awoyemi Praise-God Adetunji , Femi Qudus Arogundade , Daniel Kwaku Somuah , Addo Osei Emmanuel , Blessing Ameh , Ifedayo Samuel Oluwaseun , Anthony Ifeanyi Osu , Victor Chukwuebuka Jonathan , Chibuzor Stella Amadi , Modupe V. Oladayo , Awah Favour Matthew , Isreal Ayobami Onifade , Sodiq Fakorede , Adetolase Azizat Bakre","doi":"10.1016/j.neuroscience.2025.06.037","DOIUrl":"10.1016/j.neuroscience.2025.06.037","url":null,"abstract":"<div><div>The blood–brain barrier (BBB) is a highly selective, semi-permeable barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). Its primary function is to protect the brain from pathogens and toxins while allowing the passage of essential nutrients and gases. Bacterial translocation, the process by which bacteria move from the gut or other peripheral sites to normally sterile tissues, including the CNS, poses a significant challenge to the integrity of the BBB. This paper explores the role of the BBB in bacterial translocation, emphasizing its defense mechanisms and the conditions under which these defenses can be compromised. In normal physiological conditions, the BBB employs tight junctions between endothelial cells, active efflux transport systems, and metabolic barriers to prevent bacterial entry. However, certain bacteria have evolved mechanisms to breach the BBB, including the production of enzymes that degrade tight junction proteins, receptor-mediated transcytosis, and the induction of inflammatory responses that weaken BBB integrity. So, advances in this field may lead to novel therapeutic approaches that enhance BBB integrity or inhibit bacterial translocation mechanisms, thereby reducing the incidence and severity of bacterial infections in the brain.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 99-114"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stable expression of voltage-gated calcium channel mRNA in α2δ (CACNA2D) knockout mouse brains α2δ (CACNA2D)敲除小鼠脑内电压门控钙通道mRNA的稳定表达。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.039

Stefanie M. Geisler , Larissa Traxler , Gerald J. Obermair

{"title":"Stable expression of voltage-gated calcium channel mRNA in α2δ (CACNA2D) knockout mouse brains","authors":"Stefanie M. Geisler , Larissa Traxler , Gerald J. Obermair","doi":"10.1016/j.neuroscience.2025.06.039","DOIUrl":"10.1016/j.neuroscience.2025.06.039","url":null,"abstract":"<div><div>Voltage-gated Ca<sup>2+</sup> channels (VGCCs) regulate Ca<sup>2+</sup> entry in healthy and diseased neurons, and their function is modulated by auxiliary α<sub>2</sub>δ subunits. Among the four α<sub>2</sub>δ isoforms, α<sub>2</sub>δ-1, α<sub>2</sub>δ–2, and α<sub>2</sub>δ-3 show overlapping expression in various brain regions, raising questions about their respective specific and redundant roles. Here, we investigated if the loss of α<sub>2</sub>δ isoforms affects mRNA expression of other VGCC α<sub>1</sub>, α<sub>2</sub>δ, and β subunits. Moreover, qPCR expression profiling in knockout conditions provides insights into potential compensatory mechanisms. To this end, we analyzed the expression of the high-VGCC complement, including seven α<sub>1</sub>, four β, and four α<sub>2</sub>δ subunit isoforms, in hippocampal and striatal tissues from α<sub>2</sub>δ single and α<sub>2</sub>δ-1/-3 double knockout mice. Our findings reveal that mRNA expression profiles of hippocampal and striatal tissues contain the entire set of neuronal high-VGCC subunits. Notably, α<sub>2</sub>δ-3 mRNA is the most abundant isoform in striatum and α<sub>2</sub>δ-1/-3 double knockout mice show increased amounts of mutant α<sub>2</sub>δ-3 mRNA reporter transcripts compared to α<sub>2</sub>δ-3 single knockout mice. These findings support a critical role of α<sub>2</sub>δ-3 in GABAergic striatal medium spiny neurons. Of note, mRNA expression levels of individual α<sub>1</sub> and β isoforms were remarkably similar between α<sub>2</sub>δ single knockout and α<sub>2</sub>δ-1/-3 double knockout compared to control mice. Taken together, our study provides novel insights into the resilience of VGCC mRNA levels to disruptions of α<sub>2</sub>δ isoform expression, suggesting transcriptional stability of core calcium channel components comparable to housekeeping genes. However, this stability does not fully prevent physiological deficits, suggesting limited functional compensation at the transcript level.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 169-180"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum exosomal miR-103a-3p from patients with depression inhibits neuronal differentiation and promotes depressive behaviors in male rats 抑郁症患者血清外泌体miR-103a-3p抑制雄性大鼠神经元分化并促进抑郁行为

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-18 DOI: 10.1016/j.neuroscience.2025.06.023

Xiaojiang Huang , Xiaoping Wang , Fang Chen

{"title":"Serum exosomal miR-103a-3p from patients with depression inhibits neuronal differentiation and promotes depressive behaviors in male rats","authors":"Xiaojiang Huang , Xiaoping Wang , Fang Chen","doi":"10.1016/j.neuroscience.2025.06.023","DOIUrl":"10.1016/j.neuroscience.2025.06.023","url":null,"abstract":"<div><div>Exosomes have been identified to be involved in the pathogenesis of depression. This study the effect of exosomes isolated from the serum of patients with major depressive disorder on neuronal differentiation and the molecular mechanism. PC12 cells were treated with nerve growth factor (NGF), and neuronal differentiation was analyzed using microscopy. Synaptophysin (SYP) and nestin levels were measured by reverse transcription-quantitative polymerase chain reaction, western blot, and immunofluorescence. The depression rat model was established with chronic unpredictable mild stress (CUMS) to assess the effect of exosomal miRNA on depression-like behaviors. The results showed that exosomes inhibited NGF-induced differentiation of PC12 cells and increased miR-103a-3p expression in PC12 cells. Similarly, miR-103a-3p inhibited PC12 cell differentiation. Brain-derived neurotrophic factor (BDNF) acted as a target of miR-103a-3p that reversed the differentiation induced by miR-103a-3p. Moreover, antagomir-103a-3p alleviates depressive symptoms in CUMS rats. In conclusion, exosomal miR-103-3p promotes the progression of depression by impeding neuronal differentiation via targeting BDNF, suggesting a promising therapeutic target for depression.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 209-217"},"PeriodicalIF":2.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct connectivity patterns in clusters of inferior parietal cortex: from a cognitive control hub to modulating cortical areas 下顶叶皮层簇的独特连接模式：从认知控制中枢到调节皮质区域。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-16 DOI: 10.1016/j.neuroscience.2025.06.034

Fatemeh Tabassi Mofrad , Niels O. Schiller

{"title":"Distinct connectivity patterns in clusters of inferior parietal cortex: from a cognitive control hub to modulating cortical areas","authors":"Fatemeh Tabassi Mofrad , Niels O. Schiller","doi":"10.1016/j.neuroscience.2025.06.034","DOIUrl":"10.1016/j.neuroscience.2025.06.034","url":null,"abstract":"<div><div>The inferior parietal cortex (IPC) is a complex brain region, composed of the rostral, the middle and the caudal clusters, and functionally connected to several other parts of the brain. Various executive functions are suggested to be governed by the IPC, however, by ignoring the tripartite structure of this region, contradictory research reports abound in the literature. Here, we elaborated on the functional connectivity patterns of the clusters of the IPC, highlighting evidence that only the rostral cluster of this part of the brain is involved in cognitive control, not the entire IPC. We also underscored the unique connectivity profile of the middle and the caudal clusters which are not accommodated by the traditional classification of brain areas as either being task-based or being related to the resting-state functionality of the brain. The middle and the caudal IPC demonstrate negative functional associations with cortical areas involved in general cognitive functions, executive functions, in addition to the precuneus cortex, proportional to cognitive demand, in a modulating manner, while remaining distinct from resting-state related parts of the cortex.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 62-68"},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long term effect of COVID-19 on brain metabolism and connectivity COVID-19对脑代谢和连通性的长期影响。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-16 DOI: 10.1016/j.neuroscience.2025.06.015

Beatrice Bravi , Marco Paolini , Federica Colombo , Mariagrazia Palladini , Valentina Bettonagli , Mario Gennaro Mazza , Rebecca De Lorenzo , Patrizia Rovere-Querini , Francesco Benedetti , Sara Poletti

{"title":"Long term effect of COVID-19 on brain metabolism and connectivity","authors":"Beatrice Bravi , Marco Paolini , Federica Colombo , Mariagrazia Palladini , Valentina Bettonagli , Mario Gennaro Mazza , Rebecca De Lorenzo , Patrizia Rovere-Querini , Francesco Benedetti , Sara Poletti","doi":"10.1016/j.neuroscience.2025.06.015","DOIUrl":"10.1016/j.neuroscience.2025.06.015","url":null,"abstract":"<div><h3>Aims</h3><div>After 3 years from the beginning of SARS-CoV-2 pandemic, a substantial proportion of affected patients still present at least one symptom after infection. Given that: magnetic resonance imaging studies up to two years after COVID-19 reported changes in white matter (WM) microstructure and in functional connectivity; WM associates with glutamate and N-acetyl-aspartate levels in BD; the link between cognitive impairment and WM integrity, the aim of the study was to investigate metabolites associations with alterations in structural and functional brain connectivity and cognition in 64 COVID-19 survivors and 33 healthy controls (HC).</div></div><div><h3>Methods</h3><div>We compared WM microstructure and metabolites levels between individuals recovering from COVID-19 and HCs. Then, we investigated the associations between WM and glutamate and N-acetyl-aspartate in the two groups.</div></div><div><h3>Results</h3><div>Patients showed: higher levels of glutamate and NAA compared to HCs with a positive effect on cognitive complaints; higher fractional anisotropy (FA), and lower radial (RD) and mean diffusivity (MD); glutamate and N-acetyl-aspartate significant positive associations with FA, and a negative one with MD and RD. FA levels moderated the relation between the glutamate and cognitive deficits. Finally, N-acetyl-aspartate associated with higher rs-FC between VOI and the posterior cingulate gyrus in individuals recovering from COVID-19.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that a process of brain repair and remyelination, as suggested by higher levels of glutamate and N-acetyl-aspartate and by higher measures of WM microstructure, may occur after SARS‑CoV‑2 infection which may help the recovery from long COVID-19 symptoms such as cognitive impairment.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gabaergic neurons of central amygdala mediate anxiety-like behavior induced by social isolation in adolescent mice 中央杏仁核Gabaergic神经元介导青春期小鼠社会隔离诱导的焦虑样行为

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-15 DOI: 10.1016/j.neuroscience.2025.06.029

Yunxia Shang , Jiayi Yang , Beining Wang , Juntao Hu , Huan Liu , Zhi Zhang , Kai Wang , Tingting Sun

{"title":"Gabaergic neurons of central amygdala mediate anxiety-like behavior induced by social isolation in adolescent mice","authors":"Yunxia Shang , Jiayi Yang , Beining Wang , Juntao Hu , Huan Liu , Zhi Zhang , Kai Wang , Tingting Sun","doi":"10.1016/j.neuroscience.2025.06.029","DOIUrl":"10.1016/j.neuroscience.2025.06.029","url":null,"abstract":"<div><div>Exposure to social isolation stress during critical developmental stages escalates vulnerability to psychiatric disorders and may provoke abnormal activity in specific brain regions. In this study, we investigate the neural mechanisms underlying mood alterations following chronic social isolation stress in adolescent mice. Utilizing immunofluorescence, viral injection, <em>in vivo</em> calcium signal recording, and <em>in vitro</em> brain slice electrophysiological recordings, we found that heightened activity of GABAergic neurons in the central amygdala (CeA) contributes to anxiety-like behaviors in adolescent mice exposed to chronic social isolation stress. Inhibiting CeA GABAergic neurons through chemogenetics mitigates anxiety-like behaviors observed in emotional assessments, while activating these neurons elicits anxiety effects in various emotional measures, including the light/dark box (LDB), open field (OF), and elevated plus maze (EPM) tests. These findings not only underscore the abnormalities in brain regions caused by social isolation stress but also identify a potential target for clinical intervention.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 9-17"},"PeriodicalIF":2.9,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0