Neuroscience最新文献_第5页

Association between occupational complexity and cognitive function in older adults from Brazil and Mexico

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-30 DOI: 10.1016/j.neuroscience.2025.01.051

Natalia Gomes Goncalves , Gabriela Mininel de Medeiros , Aline Ciciliati , Jaqueline Contrera Avila , Laiss Bertola , Cleusa Ferri , Rebeca Wong , Claudia Kimie Suemoto

{"title":"Association between occupational complexity and cognitive function in older adults from Brazil and Mexico","authors":"Natalia Gomes Goncalves , Gabriela Mininel de Medeiros , Aline Ciciliati , Jaqueline Contrera Avila , Laiss Bertola , Cleusa Ferri , Rebeca Wong , Claudia Kimie Suemoto","doi":"10.1016/j.neuroscience.2025.01.051","DOIUrl":"10.1016/j.neuroscience.2025.01.051","url":null,"abstract":"<div><div>More complex occupations during adulthood may be associated with better cognition in later life. We used data from the Brazilian Longitudinal Study of Aging (ELSI) and the Mexican Health and Aging Study (MHAS) to investigate the association between occupational complexity and cognitive function. Using a regression-based approach, participants were classified as cognitively impaired or not. Occupation was categorized into four levels using the 2008 International Standard of Classification of Occupations. We used logistic regression models for separate and pooled analysis. The odds of cognitive impairment decreased with higher occupation skill levels in the ELSI, but this trend was not seen in the MHAS, where the highest skill level was not associated with cognitive impairment. ELSI participants had a lower probability of cognitive impairment compared to MHAS participants with the same occupation skill level. The results of this study suggest that programs addressing the negative consequences of lower-complexity occupations need to be tailored to specific regional contexts, considering their unique socioeconomic, cultural, and occupational landscapes.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"568 ","pages":"Pages 446-453"},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of SUMOylation exacerbates neurological dysfunction and delays hematoma clearance after intracerebral hemorrhage in mice

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.062

Keita Kinoshita , Keisuke Ushida , Yuma Hirata , Shunya Tsujita , Natsuko Hitora-Imamura , Yuki Kurauchi , Takahiro Seki , Hiroshi Katsuki

{"title":"Inhibition of SUMOylation exacerbates neurological dysfunction and delays hematoma clearance after intracerebral hemorrhage in mice","authors":"Keita Kinoshita , Keisuke Ushida , Yuma Hirata , Shunya Tsujita , Natsuko Hitora-Imamura , Yuki Kurauchi , Takahiro Seki , Hiroshi Katsuki","doi":"10.1016/j.neuroscience.2025.01.062","DOIUrl":"10.1016/j.neuroscience.2025.01.062","url":null,"abstract":"<div><div>Intracerebral hemorrhage is a kind of hemorrhagic stroke resulting from bleeding in the brain parenchyma. SUMOylation is one of post-translational protein modifications based on covalent binding of small ubiquitin-like modifier (SUMO) peptide. Although SUMOylation has been reported to play neuroprotective roles in ischemic stroke, the role of SUMOylation in the pathology of intracerebral hemorrhage remains unclear. Here we addressed the relationship between SUMOylation and pathogenesis of intracerebral hemorrhage. For <em>in vivo</em> study, hemorrhage was induced in the striatum of male ICR mice by local injection of type VII collagenase. After induction of hemorrhage, there was a significant increase in the levels of SUMO2/3 protein conjugation in the brain, without accompanying significant changes in the levels of free SUMO2/3 protein and <em>Sumo2/3</em> mRNA. When intracerebroventricular injection of TAK-981, an inhibitor of SUMOylation, was performed 3 d before hemorrhage induction, it delayed recovery of body weight, recovery of neurological functions and hematoma clearance. TAK-981 also suppressed CD36 expression in hematoma-associated microglia/macrophages. For <em>in vitro</em> study, phagocytic activity of microglial BV-2 cells was examined using erythrocytes obtained from mouse blood. We found that both TAK-981 and small interfering RNA-mediated knockdown of SUMO2/3 inhibited erythrophagocytosis by BV-2 cells. These results suggest that SUMOylation by SUMO2/3 promotes hematoma clearance via regulation of CD36 expression in microglia and contributes to the recovery from pathology of intracerebral hemorrhage.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"568 ","pages":"Pages 433-443"},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of GABA, NSE, and miR-155 expression in patients with post-stroke epilepsy.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.057

Peng Wang, Jiankang Huang, Hongbo Wen, Xiuling Liang, Jie Wang, Pengyu Ding, Jie Ding

{"title":"Clinical significance of GABA, NSE, and miR-155 expression in patients with post-stroke epilepsy.","authors":"Peng Wang, Jiankang Huang, Hongbo Wen, Xiuling Liang, Jie Wang, Pengyu Ding, Jie Ding","doi":"10.1016/j.neuroscience.2025.01.057","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.057","url":null,"abstract":"<p><p>This study investigated the clinical predictive value of cerebrospinal fluid (CSF) γ-aminobutyric acid (GABA) and serum neuron-specific enolase (NSE) and microRNA-155 (miR-155) for post-stroke epilepsy (PSE) in patients with cerebral infarction (CI). A total of 69 CI patients with PSE and 84 with non-post-stroke epilepsy (N-PSE) were retrospectively enrolled, with their clinical baseline data (CI type) and the National Institute of Health Stroke Scale (NIHSS) score collected. CSF GABA and serum NSE and miR-155 expression levels were determined, with their clinical value further assessed. The results showed that the proportions of patients with cardiogenic CI, multiple infarcts, and cortical involvement and NIHSS score in PSE patients were higher than those in N-PSE patients. CSF GABA was lowly expressed and serum NSE and miR-155 were highly expressed in PSE patients. The NIHSS score negatively correlated with GABA and positively correlated with NSE and miR-155. GABA [area under the curve (AUC) = 0.906], NSE (AUC = 0.908), miR-155 (AUC = 0.862) and their combined detection (AUC = 0.963) all had certain value in the occurrence of PSE in CI patients, with their combined detection showing higher AUC than that of single detection. Briefly, CSF GABA was reduced while serum NSE and miR-155 were elevated in PSE patients. GABA and NSE combined with miR-155 had high diagnostic value for PSE occurrence in CI patients. Lowly-expressed GABA or highly-expressed NSE and miR-155 were independent risk factors for PSE in CI patients, which could provide effective guidance for the clinical diagnosis and management of PSE.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A temporal-spatial feature fusion network for emotion recognition with individual differences reduction.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.049

Benke Liu, Yongxiong Wang, Zhe Wang, Xin Wan, Chenguang Li

{"title":"A temporal-spatial feature fusion network for emotion recognition with individual differences reduction.","authors":"Benke Liu, Yongxiong Wang, Zhe Wang, Xin Wan, Chenguang Li","doi":"10.1016/j.neuroscience.2025.01.049","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.049","url":null,"abstract":"<p><strong>Purpose: </strong>In the context of EEG-based emotion recognition tasks, a conventional strategy involves the extraction of spatial and temporal features, subsequently fused for emotion prediction. However, due to the pronounced individual variability in EEG and the constrained performance of conventional time-series models, cross-subject experiments often yield suboptimal results. To address this limitation, we propose a novel network named Time-Space Emotion Network (TSEN), which capitalizes on the fusion of spatiotemporal information for emotion recognition.</p><p><strong>Methods: </strong>Diverging from prior models that integrate temporal and spatial features, our network introduces a Convolutional Block Attention Module (CBAM) during spatial feature extraction to judiciously allocate weights to feature channels and spatial positions. Furthermore, we bolster network stability and improve domain adaptation through the incorporation of a residual block featuring Switchable Whitening (SW). Temporal feature extraction is accomplished using a Temporal Convolutional Network (TCN), ensuring elevated prediction accuracy while maintaining a lightweight network structure.</p><p><strong>Results: </strong>We conduct experiments on the preprocessed DEAP dataset. Ultimately, the average accuracy for arousal prediction is 0.7032 with a variance of 0.0876, and the F1 score is 0.6843. For valence prediction, the accuracy is 0.6792 with a variance of 0.0853, and the F1 score is 0.6826.</p><p><strong>Conclusion: </strong>TSEN exhibits high accuracy and low variance in cross-subject emotion prediction tasks, effectively reducing individual differences among different subjects. Additionally, TSEN has a smaller parameter count, enabling faster execution.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.061

Dhanshree Nibrad , Amit Shiwal , Manasi Tadas , Raj Katariya , Mayur Kale , Nandkishor Kotagale , Milind Umekar , Brijesh Taksande

{"title":"Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders","authors":"Dhanshree Nibrad , Amit Shiwal , Manasi Tadas , Raj Katariya , Mayur Kale , Nandkishor Kotagale , Milind Umekar , Brijesh Taksande","doi":"10.1016/j.neuroscience.2025.01.061","DOIUrl":"10.1016/j.neuroscience.2025.01.061","url":null,"abstract":"<div><div>Mitochondrial dysfunction is a pivotal factor in the pathogenesis of neurodegenerative disorders, driving neuronal degeneration through mechanisms involving oxidative stress, impaired energy production, and dysregulated calcium homeostasis. Agmatine, an endogenous polyamine derived from arginine, has garnered attention for its neuroprotective properties, including anti-inflammatory, anti-oxidative, and antiapoptotic effects. Recent studies have highlighted the potential of agmatine in preserving mitochondrial function and mitigating neurodegeneration, making it a promising candidate for therapeutic intervention. One of the key mechanisms by which agmatine exerts its neuroprotective effects is through the maintenance of mitochondrial homeostasis. Agmatine has been shown to modulate mitochondrial dynamics, promoting mitochondrial fusion and fission balance essential for cellular energy metabolism and signaling. Moreover, agmatine acts as a regulator of mitochondrial permeability transition pore (mPTP) opening, preventing excessive calcium influx and subsequent mitochondrial dysfunction. Despite promising findings, challenges such as optimizing agmatine’s pharmacokinetics, determining optimal dosing regimens, and elucidating its precise molecular targets within mitochondria remain to be addressed. Future research directions should focus on developing targeted delivery systems for agmatine, investigating its interactions with mitochondrial proteins, and conducting well-designed clinical trials to evaluate its therapeutic efficacy and safety profile in neurodegenerative disorders. Overall, agmatine emerges as a novel therapeutic agent with the potential to modulate mitochondrial homeostasis and alleviate neurodegenerative pathology, offering new avenues for treating these debilitating conditions.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"569 ","pages":"Pages 43-57"},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public perceptions of brain health in young and middle-aged adults in Cuba: Opportunities for intervention

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-28 DOI: 10.1016/j.neuroscience.2025.01.052

Yunier Broche-Pérez , Zoylen Fernández-Fleites , Diego D. Díaz-Guerra , Marena de la C. Hernández-Lugo , Carlos Ramos-Galarza

{"title":"Public perceptions of brain health in young and middle-aged adults in Cuba: Opportunities for intervention","authors":"Yunier Broche-Pérez , Zoylen Fernández-Fleites , Diego D. Díaz-Guerra , Marena de la C. Hernández-Lugo , Carlos Ramos-Galarza","doi":"10.1016/j.neuroscience.2025.01.052","DOIUrl":"10.1016/j.neuroscience.2025.01.052","url":null,"abstract":"<div><div>Understanding brain health is increasingly important, particularly in light of growing public health challenges related to neurological and psychiatric conditions. These include the rising prevalence of mental health disorders, such as depression and anxiety, as well as neurodegenerative diseases like Alzheimer’s and Parkinson’s. Lifestyle factors, including stress, poor diet, and insufficient physical activity, also significantly impact cognitive function. Exploring the perceptions and awareness of brain health among young and middle-aged adults is crucial to developing effective educational programs and awareness campaigns tailored to their specific needs. This study aimed to examine the perceptions and awareness of brain health among Cuban youth, focusing on the factors that shape their understanding and attitudes toward brain well-being. A cross-sectional online survey was conducted, with 1,049 participants voluntarily completing the questionnaire. Using “The Global Brain Health Survey,” we assessed participants’ conceptions of brain health and analyzed associations between demographic variables and brain health knowledge through logistic regression. Our findings revealed that the social environment was viewed as the most significant factor influencing brain health. Other factors, such as profession, genetics, income, and nutrition, were considered important but to a lesser degree. While participants were generally aware of conditions like Alzheimer’s disease and depression, there was a notable gap in understanding the cognitive implications of chronic diseases such as hypertension and diabetes, which are prevalent in Cuba. These insights highlight the need for targeted public health initiatives and educational campaigns that promote healthier behaviors and community support, particularly among young adults.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"568 ","pages":"Pages 419-432"},"PeriodicalIF":2.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-28 DOI: 10.1016/j.neuroscience.2025.01.055

Retaj Al Harbi, Abdeslam Mouihate

{"title":"Maternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6","authors":"Retaj Al Harbi, Abdeslam Mouihate","doi":"10.1016/j.neuroscience.2025.01.055","DOIUrl":"10.1016/j.neuroscience.2025.01.055","url":null,"abstract":"<div><div>Maternal immune activation (MIA) induces long-term cognitive impairments by modulating the gamma-aminobutyric acid (GABA)ergic system. Experimental evidence suggests that maternal immune challenge with bacterial active ingredient lipopolysaccharide (LPS) reduces GABAergic tone in the offspring’s prefrontal cortex. In this study, we aimed to assess whether interleukin-6 (IL-6) contributes to this reduced GABAergic system in the prefrontal cortex of juvenile offspring. Pregnant rats were given intraperitoneal injections of either LPS (100 µg/Kg) or a pyrogen-free saline solution in the absence or the presence of an IL-6 neutralizing antibody (IL-6Ab, 10 µg/Kg) on gestation day (GD) 15, GD17 and GD19. Parvalbumin and somatostatin GABAergic interneurons and the density of inhibitory synapses were monitored in 30-day-old male and female rat offspring using fluorescent immunohistochemistry. The expression levels of Cl<sup>-</sup> transporters (NKCC1 and KCC2) were assessed using western blotting. Prenatal LPS induced a significant reduction in the cell density of parvalbumin-containing interneurons in the prefrontal cortex of female but not male rat offspring. LPS-induced MIA led to a reduction in the expression levels of NKCC1 in the prefrontal cortices of both male and female offspring. These long-lasting impacts of the MIA were alleviated when the IL-6Ab was co-administered with LPS during pregnancy. This study shows that the GABAergic system in the prefrontal cortex of female rats is highly sensitive to prenatal immune challenges. These data pave the way for exploring the specific mechanism(s) underlying the sex-dependent effects of early-life immune challenges.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"568 ","pages":"Pages 399-407"},"PeriodicalIF":2.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of a central amygdaloid nucleus-lateral habenular nucleus pathway in the processing of formalin-induced pain.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-28 DOI: 10.1016/j.neuroscience.2025.01.054

Wen-Jun Zhao, Hui-Jie Feng, Shan Wang, Chu-Han Liu, Pei-Yuan Lv, Hui Zhu, Peng-Xin Zhang, Xue-Yu Hu, Jia-Ni Li, Yu-Lin Dong

{"title":"Involvement of a central amygdaloid nucleus-lateral habenular nucleus pathway in the processing of formalin-induced pain.","authors":"Wen-Jun Zhao, Hui-Jie Feng, Shan Wang, Chu-Han Liu, Pei-Yuan Lv, Hui Zhu, Peng-Xin Zhang, Xue-Yu Hu, Jia-Ni Li, Yu-Lin Dong","doi":"10.1016/j.neuroscience.2025.01.054","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.054","url":null,"abstract":"<p><p>The central amygdaloid nucleus (CeA) and the lateral habenular nucleus (LHb) are essential nuclei playing modulatory roles in encoding noxious stimuli. Their interaction has recently been demonstrated in chronic pain-induced depression. However, little is known about the CeA-LHb pathway in a formalin-induced pain model. In the present study, we aimed to clarify whether the CeA-LHb pathway modulates the formalin-induced pain model using a neuroanatomical tracing method combined with a designer receptor exclusively activated by a designer drugs strategy (DREADD). The results revealed that the CeA predominantly sends projections to vesicular glutamate transporter-2 (VGluT2)-expressing neurons of the LHb, and inhibition of LHb function exhibits an analgesic effect in the formalin-induced pain model. Furthermore, activating the CeA-LHb pathway significantly attenuates pain sensation only in phase 2 of formalin-induced pain in mice. The present results indicate the participation of the LHb in inflammatory pain sensation and reveal a CeA-LHb<sup>VGluT2</sup> pathway that displays analgesic effects in a formalin pain model.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between morphometric similarity network and brain gene expression in type 2 diabetes mellitus.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-28 DOI: 10.1016/j.neuroscience.2025.01.053

Qiaohui Liu, Xin Du, Yang Zhang, Hao Ding, Wen Qin, Quan Zhang

{"title":"Associations between morphometric similarity network and brain gene expression in type 2 diabetes mellitus.","authors":"Qiaohui Liu, Xin Du, Yang Zhang, Hao Ding, Wen Qin, Quan Zhang","doi":"10.1016/j.neuroscience.2025.01.053","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.053","url":null,"abstract":"<p><p>Abnormal functional and structural connectivity of brain networks is commonly observed in patients with type 2 diabetes mellitus (T2DM) and accompanied bycognitive impairment. In this study, we revealed differences in brain structure in T2DM using a Morphometric Similarity Network (MSN) method, which quantifies structural similarities between brain regions. The associations between T2DM-associated changes in morphometric similarity (MS) and gene expression were analyzed to explore the molecular and cellular mechanism underlying MS changes in T2DM. Our research involved 3D-T1WI and DTI data from 157 T2DM patients and 147 healthy controls (HCs) adequately matched. In patients with T2DM, the global MS was decreased. The MS decreased in the regions within the left sensorimotor network and the right salience/ventral attention network and increased in the regions within the bilateral visual network in the patient group. The increased MS of the bilateral visual networks in T2DM patients was negatively correlated with memory function. The transcription-neuroimaging association analysis indicated that the expression of 298 genes was significantly spatially correlated with the T2DM-related MSN abnormalities, and some of these genes are involved in biological processes such as central nervous system development and neurotransmitter transmission, which may provide possible molecular and cellular substrates for MS abnormalities and cognitive decline in T2DM.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-27 DOI: 10.1016/j.neuroscience.2025.01.048

Barbara D. Fontana , Laura Blanco , Angela E. Uchoa , Mariana L. Müller , Falco L. Gonçalves , Cássio M. Resmim , João V. Borba , Julia Canzian , Denis B Rosemberg

{"title":"Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish","authors":"Barbara D. Fontana , Laura Blanco , Angela E. Uchoa , Mariana L. Müller , Falco L. Gonçalves , Cássio M. Resmim , João V. Borba , Julia Canzian , Denis B Rosemberg","doi":"10.1016/j.neuroscience.2025.01.048","DOIUrl":"10.1016/j.neuroscience.2025.01.048","url":null,"abstract":"<div><div>Epilepsy, a neurological disorder causing recurring seizures, is often studied in zebrafish by exposing animals to pentylenetetrazol (PTZ), which induces clonic- and tonic-like behaviors. While adult zebrafish seizure-like behaviors are well characterized, manual assessment remains challenging due to its time-consuming nature, potential for human error/bias, and the risk of overlooking subtle behaviors. Aiming to circumvent these issues, we developed a machine learning model for automating the analysis of subtle abnormal and seizure-like behaviors in PTZ-exposed adult zebrafish. To improve pharmacological validity, we also evaluated the efficacy of two anticonvulsant drugs, diazepam (DZP) and valproate (VALP). As strategy, we employed a Random Forest algorithm combined with a post-processing analysis to identify six behavioral phenotypes in PTZ-exposed zebrafish. We found a concentration-dependent effect of PTZ and a distinct behavioral phenotype for DZP and VALP, where these drugs showed different protective profiles. Altogether, our novel data highlights the use of machine learning models to better understand complex behavioral phenotypes associated to PTZ-induced seizures. The ability to detect frame-by-frame and distinct actions of anticonvulsant drugs provides new perspectives on measuring seizure-like responses, as well as possible therapeutic strategies. The approach used here constitutes an important leap on behavioral analysis that can accelerate the discovery of new treatments for seizure disorders.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"568 ","pages":"Pages 377-387"},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0