Neuroscience最新文献_第5页

Stable expression of voltage-gated calcium channel mRNA in α2δ (CACNA2D) knockout mouse brains α2δ (CACNA2D)敲除小鼠脑内电压门控钙通道mRNA的稳定表达。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-19 DOI: 10.1016/j.neuroscience.2025.06.039

Stefanie M. Geisler , Larissa Traxler , Gerald J. Obermair

{"title":"Stable expression of voltage-gated calcium channel mRNA in α2δ (CACNA2D) knockout mouse brains","authors":"Stefanie M. Geisler , Larissa Traxler , Gerald J. Obermair","doi":"10.1016/j.neuroscience.2025.06.039","DOIUrl":"10.1016/j.neuroscience.2025.06.039","url":null,"abstract":"<div><div>Voltage-gated Ca<sup>2+</sup> channels (VGCCs) regulate Ca<sup>2+</sup> entry in healthy and diseased neurons, and their function is modulated by auxiliary α<sub>2</sub>δ subunits. Among the four α<sub>2</sub>δ isoforms, α<sub>2</sub>δ-1, α<sub>2</sub>δ–2, and α<sub>2</sub>δ-3 show overlapping expression in various brain regions, raising questions about their respective specific and redundant roles. Here, we investigated if the loss of α<sub>2</sub>δ isoforms affects mRNA expression of other VGCC α<sub>1</sub>, α<sub>2</sub>δ, and β subunits. Moreover, qPCR expression profiling in knockout conditions provides insights into potential compensatory mechanisms. To this end, we analyzed the expression of the high-VGCC complement, including seven α<sub>1</sub>, four β, and four α<sub>2</sub>δ subunit isoforms, in hippocampal and striatal tissues from α<sub>2</sub>δ single and α<sub>2</sub>δ-1/-3 double knockout mice. Our findings reveal that mRNA expression profiles of hippocampal and striatal tissues contain the entire set of neuronal high-VGCC subunits. Notably, α<sub>2</sub>δ-3 mRNA is the most abundant isoform in striatum and α<sub>2</sub>δ-1/-3 double knockout mice show increased amounts of mutant α<sub>2</sub>δ-3 mRNA reporter transcripts compared to α<sub>2</sub>δ-3 single knockout mice. These findings support a critical role of α<sub>2</sub>δ-3 in GABAergic striatal medium spiny neurons. Of note, mRNA expression levels of individual α<sub>1</sub> and β isoforms were remarkably similar between α<sub>2</sub>δ single knockout and α<sub>2</sub>δ-1/-3 double knockout compared to control mice. Taken together, our study provides novel insights into the resilience of VGCC mRNA levels to disruptions of α<sub>2</sub>δ isoform expression, suggesting transcriptional stability of core calcium channel components comparable to housekeeping genes. However, this stability does not fully prevent physiological deficits, suggesting limited functional compensation at the transcript level.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 169-180"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum exosomal miR-103a-3p from patients with depression inhibits neuronal differentiation and promotes depressive behaviors in male rats 抑郁症患者血清外泌体miR-103a-3p抑制雄性大鼠神经元分化并促进抑郁行为

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-18 DOI: 10.1016/j.neuroscience.2025.06.023

Xiaojiang Huang , Xiaoping Wang , Fang Chen

{"title":"Serum exosomal miR-103a-3p from patients with depression inhibits neuronal differentiation and promotes depressive behaviors in male rats","authors":"Xiaojiang Huang , Xiaoping Wang , Fang Chen","doi":"10.1016/j.neuroscience.2025.06.023","DOIUrl":"10.1016/j.neuroscience.2025.06.023","url":null,"abstract":"<div><div>Exosomes have been identified to be involved in the pathogenesis of depression. This study the effect of exosomes isolated from the serum of patients with major depressive disorder on neuronal differentiation and the molecular mechanism. PC12 cells were treated with nerve growth factor (NGF), and neuronal differentiation was analyzed using microscopy. Synaptophysin (SYP) and nestin levels were measured by reverse transcription-quantitative polymerase chain reaction, western blot, and immunofluorescence. The depression rat model was established with chronic unpredictable mild stress (CUMS) to assess the effect of exosomal miRNA on depression-like behaviors. The results showed that exosomes inhibited NGF-induced differentiation of PC12 cells and increased miR-103a-3p expression in PC12 cells. Similarly, miR-103a-3p inhibited PC12 cell differentiation. Brain-derived neurotrophic factor (BDNF) acted as a target of miR-103a-3p that reversed the differentiation induced by miR-103a-3p. Moreover, antagomir-103a-3p alleviates depressive symptoms in CUMS rats. In conclusion, exosomal miR-103-3p promotes the progression of depression by impeding neuronal differentiation via targeting BDNF, suggesting a promising therapeutic target for depression.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 209-217"},"PeriodicalIF":2.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct connectivity patterns in clusters of inferior parietal cortex: from a cognitive control hub to modulating cortical areas 下顶叶皮层簇的独特连接模式：从认知控制中枢到调节皮质区域。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-16 DOI: 10.1016/j.neuroscience.2025.06.034

Fatemeh Tabassi Mofrad , Niels O. Schiller

{"title":"Distinct connectivity patterns in clusters of inferior parietal cortex: from a cognitive control hub to modulating cortical areas","authors":"Fatemeh Tabassi Mofrad , Niels O. Schiller","doi":"10.1016/j.neuroscience.2025.06.034","DOIUrl":"10.1016/j.neuroscience.2025.06.034","url":null,"abstract":"<div><div>The inferior parietal cortex (IPC) is a complex brain region, composed of the rostral, the middle and the caudal clusters, and functionally connected to several other parts of the brain. Various executive functions are suggested to be governed by the IPC, however, by ignoring the tripartite structure of this region, contradictory research reports abound in the literature. Here, we elaborated on the functional connectivity patterns of the clusters of the IPC, highlighting evidence that only the rostral cluster of this part of the brain is involved in cognitive control, not the entire IPC. We also underscored the unique connectivity profile of the middle and the caudal clusters which are not accommodated by the traditional classification of brain areas as either being task-based or being related to the resting-state functionality of the brain. The middle and the caudal IPC demonstrate negative functional associations with cortical areas involved in general cognitive functions, executive functions, in addition to the precuneus cortex, proportional to cognitive demand, in a modulating manner, while remaining distinct from resting-state related parts of the cortex.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 62-68"},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long term effect of COVID-19 on brain metabolism and connectivity COVID-19对脑代谢和连通性的长期影响。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-16 DOI: 10.1016/j.neuroscience.2025.06.015

Beatrice Bravi , Marco Paolini , Federica Colombo , Mariagrazia Palladini , Valentina Bettonagli , Mario Gennaro Mazza , Rebecca De Lorenzo , Patrizia Rovere-Querini , Francesco Benedetti , Sara Poletti

{"title":"Long term effect of COVID-19 on brain metabolism and connectivity","authors":"Beatrice Bravi , Marco Paolini , Federica Colombo , Mariagrazia Palladini , Valentina Bettonagli , Mario Gennaro Mazza , Rebecca De Lorenzo , Patrizia Rovere-Querini , Francesco Benedetti , Sara Poletti","doi":"10.1016/j.neuroscience.2025.06.015","DOIUrl":"10.1016/j.neuroscience.2025.06.015","url":null,"abstract":"<div><h3>Aims</h3><div>After 3 years from the beginning of SARS-CoV-2 pandemic, a substantial proportion of affected patients still present at least one symptom after infection. Given that: magnetic resonance imaging studies up to two years after COVID-19 reported changes in white matter (WM) microstructure and in functional connectivity; WM associates with glutamate and N-acetyl-aspartate levels in BD; the link between cognitive impairment and WM integrity, the aim of the study was to investigate metabolites associations with alterations in structural and functional brain connectivity and cognition in 64 COVID-19 survivors and 33 healthy controls (HC).</div></div><div><h3>Methods</h3><div>We compared WM microstructure and metabolites levels between individuals recovering from COVID-19 and HCs. Then, we investigated the associations between WM and glutamate and N-acetyl-aspartate in the two groups.</div></div><div><h3>Results</h3><div>Patients showed: higher levels of glutamate and NAA compared to HCs with a positive effect on cognitive complaints; higher fractional anisotropy (FA), and lower radial (RD) and mean diffusivity (MD); glutamate and N-acetyl-aspartate significant positive associations with FA, and a negative one with MD and RD. FA levels moderated the relation between the glutamate and cognitive deficits. Finally, N-acetyl-aspartate associated with higher rs-FC between VOI and the posterior cingulate gyrus in individuals recovering from COVID-19.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that a process of brain repair and remyelination, as suggested by higher levels of glutamate and N-acetyl-aspartate and by higher measures of WM microstructure, may occur after SARS‑CoV‑2 infection which may help the recovery from long COVID-19 symptoms such as cognitive impairment.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gabaergic neurons of central amygdala mediate anxiety-like behavior induced by social isolation in adolescent mice 中央杏仁核Gabaergic神经元介导青春期小鼠社会隔离诱导的焦虑样行为

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-15 DOI: 10.1016/j.neuroscience.2025.06.029

Yunxia Shang , Jiayi Yang , Beining Wang , Juntao Hu , Huan Liu , Zhi Zhang , Kai Wang , Tingting Sun

{"title":"Gabaergic neurons of central amygdala mediate anxiety-like behavior induced by social isolation in adolescent mice","authors":"Yunxia Shang , Jiayi Yang , Beining Wang , Juntao Hu , Huan Liu , Zhi Zhang , Kai Wang , Tingting Sun","doi":"10.1016/j.neuroscience.2025.06.029","DOIUrl":"10.1016/j.neuroscience.2025.06.029","url":null,"abstract":"<div><div>Exposure to social isolation stress during critical developmental stages escalates vulnerability to psychiatric disorders and may provoke abnormal activity in specific brain regions. In this study, we investigate the neural mechanisms underlying mood alterations following chronic social isolation stress in adolescent mice. Utilizing immunofluorescence, viral injection, <em>in vivo</em> calcium signal recording, and <em>in vitro</em> brain slice electrophysiological recordings, we found that heightened activity of GABAergic neurons in the central amygdala (CeA) contributes to anxiety-like behaviors in adolescent mice exposed to chronic social isolation stress. Inhibiting CeA GABAergic neurons through chemogenetics mitigates anxiety-like behaviors observed in emotional assessments, while activating these neurons elicits anxiety effects in various emotional measures, including the light/dark box (LDB), open field (OF), and elevated plus maze (EPM) tests. These findings not only underscore the abnormalities in brain regions caused by social isolation stress but also identify a potential target for clinical intervention.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 9-17"},"PeriodicalIF":2.9,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts to mental and brain health on irregular and deported Colombian Migrants: Implications for policy and practice 非正规和被驱逐的哥伦比亚移民对精神和大脑健康的影响：对政策和做法的影响

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-15 DOI: 10.1016/j.neuroscience.2025.06.020

C. Correa-Salazar , G. Rangel , J. Blandón , E.N. Agudelo-Avellaneda , D.S. Torres-Benitez , N. Quintero-Medina , V. Saray-Jaimes , M.L. Restrepo-Mantilla , E. Chaux-Rettberg , A. Martínez-Donate

{"title":"Impacts to mental and brain health on irregular and deported Colombian Migrants: Implications for policy and practice","authors":"C. Correa-Salazar , G. Rangel , J. Blandón , E.N. Agudelo-Avellaneda , D.S. Torres-Benitez , N. Quintero-Medina , V. Saray-Jaimes , M.L. Restrepo-Mantilla , E. Chaux-Rettberg , A. Martínez-Donate","doi":"10.1016/j.neuroscience.2025.06.020","DOIUrl":"10.1016/j.neuroscience.2025.06.020","url":null,"abstract":"<div><div>Latin Americahas experienced one of the most pronounced increases in human mobility globally. Migration is a structural determinant ofhealthfor key vulnerable populations. The objective of this study was to examine the associations between mental health outcomes with structural and individual determinants of health for pre-departure and deported Colombians. We hypothesized that experiences of violence, adverse experiences before migration and less social capital significantly impact perceived mental health and brain health by proxy. We conducted a cross-sectional study in Bogotá to assess the feasibility of a Migrant Health Observatory. This novel study sampled hidden and hard-to-reach populations. We found socioeconomic status, gender and age as determinants of mental health for pre-departure migrants, which induced their decision to migrate irregularly. Deported individuals face greater vulnerabilities given greater prevalence of adverse childhood experiences, more dependents and greater food insecurity. Our results have important implications for policy and practice, indicating the need for tailored mental health and social support interventions that consider women, children and adolescents, and food insecure people as key populations in need of assistance, and at risk of being exposed to irregular migration-associated risks. Our study also points to key targets for intervention and policies to protect mental and brain health in the region. This study shows how brain health can be affected in the growing migratory context of the Americas. Our approach addresses mental health as a proxy of brain health to describe how migration and individual differences impact pre-departure migrants and deported Colombians.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 46-53"},"PeriodicalIF":2.9,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired glymphatic system function in relapsing-remitting multiple Sclerosis: Insights from diffusion tensor imaging along the perivascular space (DTI-ALPS) 复发缓解型多发性硬化症中淋巴系统功能受损：沿血管周围空间扩散张量成像（DTI-ALPS）的见解

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-14 DOI: 10.1016/j.neuroscience.2025.06.028

Wenqian Zhao , Xueao Li , Jing Wang , Liufei Yang , Yuchuan Zhuang , Yanbo Dong , Andrey Tulupov , Jing Li , Jubao Sun , Jinghua Li , Kun Lei , Fengshou Zhang , Jianfeng Bao

{"title":"Impaired glymphatic system function in relapsing-remitting multiple Sclerosis: Insights from diffusion tensor imaging along the perivascular space (DTI-ALPS)","authors":"Wenqian Zhao , Xueao Li , Jing Wang , Liufei Yang , Yuchuan Zhuang , Yanbo Dong , Andrey Tulupov , Jing Li , Jubao Sun , Jinghua Li , Kun Lei , Fengshou Zhang , Jianfeng Bao","doi":"10.1016/j.neuroscience.2025.06.028","DOIUrl":"10.1016/j.neuroscience.2025.06.028","url":null,"abstract":"<div><div>In relapsing-remitting multiple sclerosis (RRMS) patients, an enlarged perivascular space, cognitive impairment, and inflammatory immune response has been associated with the glymphatic dysfunction. Therefore, we employed the diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate glymphatic function in RRMS patients. The study included 39 RRMS patients and 34 age- and gender-matched healthy controls (HC). We calculated the DTI-ALPS index by placing regions of interest (ROIs) in projection and association fiber areas, adjusting for any unsuitable positions following visual inspection. Lesion masks were created based on T2 FLAIR images, and then the measured diffusion coefficients along the x, y, and z axes were calculated after removing the lesion areas, and then DTI-ALPS index was calculated. The DTI-ALPS index between the RRMS and HC groups using two-sample <em>t</em>-test using SPSS 27.0. Additionally, we calculated DTI metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Furthermore, we explored the association between the DTI-ALPS index and DTI metrics, as well as clinical variables such as disease duration and clinical disability score. The RRMS group showed a significantly lower DTI-ALPS index compared to HC group, suggesting altered water diffusivity along perivascular spaces. The DTI-ALPS index demonstrated a negative correlation with clinical disability and disease duration, with RRMS patients exhibiting decreased FA and increased MD, AD, and RD. These results suggest that changes in the DTI-ALPS index may be associated with microstructural damage and disease progression in RRMS, and may indirectly indicate impaired glymphatic function in RRMS.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 27-34"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Δ133p53α-mediated inhibition of astrocyte senescence and neurotoxicity as a possible therapeutic approach for neurodegenerative diseases Δ133p53α-mediated星形胶质细胞衰老和神经毒性的抑制作为神经退行性疾病的可能治疗方法。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-14 DOI: 10.1016/j.neuroscience.2025.06.031

Izumi Horikawa , Leo Yamada , Brent T. Harris , Curtis C. Harris

{"title":"Δ133p53α-mediated inhibition of astrocyte senescence and neurotoxicity as a possible therapeutic approach for neurodegenerative diseases","authors":"Izumi Horikawa , Leo Yamada , Brent T. Harris , Curtis C. Harris","doi":"10.1016/j.neuroscience.2025.06.031","DOIUrl":"10.1016/j.neuroscience.2025.06.031","url":null,"abstract":"<div><div>Non-neuronal glial cells in the brain, such as astrocytes, play essential roles in maintaining the functional integrity of neuronal cells. A growing body of evidence suggests that cellular senescence of astrocytes, characterized by loss of proliferative potential and secretion of neurotoxic cytokines, makes significant contribution to neurotoxicity in Alzheimer’s disease and a wide range of other neurodegenerative diseases. This review discusses the beneficial effects of Δ133p53α, a natural p53 protein isoform that inhibits p53-mediated cellular senescence, thereby protecting astrocytes from senescence, highlights its potential as a therapeutic target, and underscores the need for continued research in this area. Both in senescent human astrocytes in culture, whether induced by replicative exhaustion, irradiation or exposure to amyloid-β, and in brain tissues with increased senescent astrocytes from patients with Alzheimer’s disease, the expression levels of endogenous Δ133p53α protein were consistently and significantly reduced. The lentiviral vector-driven expression of Δ133p53α protected cultured human astrocytes from cellular senescence and neurotoxic secretory phenotype, leading to their cellular reprogramming to a neuroprotective state associated with neurotrophic growth factors. We thus propose that Δ133p53α is worth testing as a therapeutic target that can be enhanced in a wide range of neurodegenerative diseases with accumulated senescent astrocytes, including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and chronic traumatic encephalopathy due to traumatic brain injury. We hypothesize that a Δ133p53α-mediated cellular reprogramming approach and a senolytic or senomorphic approach, both targeting non-neuronal cells, may be complementary with each other, and may cooperate with neuron-protecting or amyloid-β-targeting therapies currently in use.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 54-61"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-14 DOI: 10.1016/j.neuroscience.2025.06.022

Yue Yu , Gaoxiang Ouyang , Jin Li , Dan Cao

{"title":"Age-related differences in cognitive reappraisal: The role of cognitive function and implications for emotional regulation","authors":"Yue Yu , Gaoxiang Ouyang , Jin Li , Dan Cao","doi":"10.1016/j.neuroscience.2025.06.022","DOIUrl":"10.1016/j.neuroscience.2025.06.022","url":null,"abstract":"<div><div>Recent research on cognitive reappraisal has highlighted age-related differences in emotional regulation strategies. Younger adults, often relying on stronger executive functions and cognitive resources, tend to favor detached reappraisal strategies. In contrast, older adults tend to draw on their rich life experience and emotional regulation abilities, and are more likely to adopt positive reappraisal. These differences in strategy selection may be related to age-related differences in neural activity. Young adults rely more on prefrontal cognitive control regions to rapidly suppress emotional responses, whereas older adults tend to regulate emotions by reconstructing their emotional meaning, which may contribute to age-related preferences in cognitive reappraisal. Additionally, these differences in strategy use may also be influenced by age-related cognitive decline—Such distinctions may be associated with age-related declines in cognitive functions, such as memory, attention, and executive function, which can constrain strategy choice for older adults in specific contexts. This review systematically explores age differences in cognitive reappraisal strategies and neural mechanisms, and illustrate cognitive functioning as a possible cause influencing the cognitive reappraisal. Lastly, we discuss the potential of cognitive training to enhance cognitive function in older adults, thereby optimizing their emotional regulation strategies and offering directions for future research.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"579 ","pages":"Pages 312-320"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.9 3区医学

Neuroscience Pub Date : 2025-06-14 DOI: 10.1016/j.neuroscience.2025.06.032

Yeeun Bae , Harshini Venkat , Natalie Preveza , W.Keith Ray , Richard F. Helm , Timothy J. Jarome

{"title":"Age-related dysregulation of proteasome-independent K63 polyubiquitination in the hippocampus and amygdala","authors":"Yeeun Bae , Harshini Venkat , Natalie Preveza , W.Keith Ray , Richard F. Helm , Timothy J. Jarome","doi":"10.1016/j.neuroscience.2025.06.032","DOIUrl":"10.1016/j.neuroscience.2025.06.032","url":null,"abstract":"<div><div>Cognitive decline with aging is a complex process involving multiple brain regions and molecular mechanisms. While the role of the canonical protein degradation function of the ubiquitin–proteasome system (UPS) has been well studied in the context of aging and age-associated memory loss, the non-proteolytic functions of ubiquitin activity remain poorly understood. Here, we investigated the role of lysine-63 (K63) polyubiquitination, the most abundant form of proteasome-independent ubiquitination, in aged rats, focusing on the hippocampus and amygdala, two brain regions reported to have cellular and molecular alterations with age that are associated with age-related memory loss. Using an unbiased proteomic approach, we observed a significant increase of K63 polyubiquitination in the hippocampus across the lifespan. Reducing K63 polyubiquitination in the hippocampus of aged male rats using the CRISPR-dCas13 RNA editing system enhanced contextual fear memory, while similar manipulations in middle-aged rats, which typically have normal memory, had no effect, emphasizing the age-dependent role of K63 polyubiquitination in memory formation. Conversely, the amygdala showed a consistent reduction of K63 polyubiquitination protein targets across the lifespan, and further reductions of K63 polyubiquitination improved memory retention in aged, but not middle-aged, male rats. Together, our findings reveal the dynamic and region-specific functions of K63 polyubiquitination in the brain aging process, providing novel insights into its contribution to age-associated memory decline.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"580 ","pages":"Pages 18-26"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0