Neuroscience最新文献_第6页

Upregulated excitatory amino acid transporter 1 (EAAT1) expression in the human medial temporal lobe in Alzheimer's disease. 阿尔茨海默病中人类内侧颞叶兴奋性氨基酸转运蛋白1 （EAAT1）表达上调

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-06 Epub Date: 2024-12-16 DOI: 10.1016/j.neuroscience.2024.12.027

Oliver W G Wood, Jason H Y Yeung, Thulani H Palpagama, Clinton Turner, Henry J Waldvogel, Richard L M Faull, Andrea Kwakowsky

{"title":"Upregulated excitatory amino acid transporter 1 (EAAT1) expression in the human medial temporal lobe in Alzheimer's disease.","authors":"Oliver W G Wood, Jason H Y Yeung, Thulani H Palpagama, Clinton Turner, Henry J Waldvogel, Richard L M Faull, Andrea Kwakowsky","doi":"10.1016/j.neuroscience.2024.12.027","DOIUrl":"10.1016/j.neuroscience.2024.12.027","url":null,"abstract":"Alzheimer's disease (AD) is a growing health problem worldwide, particularly in the developed world due to an ageing population. Glutamate excitotoxicity plays a major role in the pathophysiology of AD, and glutamate re-uptake is controlled by excitatory amino acid transporters (EAATs). The EAAT2 isoform is the predominant transporter involved in glutamate reuptake, therefore EAAT1 has not been the focus of AD research. We investigated the layer-specific expression of EAAT1 in human medial temporal lobe regions such as the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus, using fluorescent immunohistochemistry and laser scanning confocal microscopy in human post-mortem tissue. We observed low EAAT1 immunoreactivity in control cases, but upregulated labeling in AD across several brain regions of the medial temporal lobe. Significantly higher integrated density in AD cases was observed in the str. oriens and str. radiatum of the CA2 region, the str. pyramidale of CA3, and the str. moleculare and str. granulosum of the DG. Labeling of EAAT1 appeared astrocytic in nature, showing close association with astrocytic processes in AD cases. We also report that a higher EAAT1 density was positively correlated with the age of AD cases, but this relationship was not observed in control cases. Overall, our results indicate an upregulation of EAAT1 across several hippocampal subregions and layers in AD cases, indicating a potential physiological role for this transporter that needs further investigation.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"87-96"},"PeriodicalIF":2.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central corticotropin releasing hormone receptor 2 may participate in sex differential regulation of cold-evoked eating behavior. 中枢促肾上腺皮质激素释放激素受体2可能参与冷诱发进食行为的性别差异调节。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-06 Epub Date: 2024-12-27 DOI: 10.1016/j.neuroscience.2024.12.053

Ying Zhou, Shuqing Zhu, Shangwu Ye, Ziyuan Ye, Wenxi Chen, Jieshan Li, Gang Shu, Songbo Wang, Canjun Zhu, Ruifan Wu, Qingyan Jiang, Lina Wang

{"title":"Central corticotropin releasing hormone receptor 2 may participate in sex differential regulation of cold-evoked eating behavior.","authors":"Ying Zhou, Shuqing Zhu, Shangwu Ye, Ziyuan Ye, Wenxi Chen, Jieshan Li, Gang Shu, Songbo Wang, Canjun Zhu, Ruifan Wu, Qingyan Jiang, Lina Wang","doi":"10.1016/j.neuroscience.2024.12.053","DOIUrl":"10.1016/j.neuroscience.2024.12.053","url":null,"abstract":"Corticotropin-releasing factor (CRF) is an important stress hormone, and because of the different distributions and functions of its receptors, CRF has various effects on the stress response of animals. CRF receptor 2 (CRFR2) is a functional receptor of CRF that may be related to appetite regulation and sex differences. In this study, male and female C57BL/6 mice were exposed to an ambient temperature of 4 °C, and feed intake were determined. Consequently, neuronal excitability, as well as the expression of CRFR2 and related genes in the brain were determined. As a result, 1) there were only significant changes in 2 h feed intake and rectal temperature in males; 2) neuronal excitability was elevated in the paraventricular thalamus (PVT) and paraventricular hypothalamic nucleus (PVH) brain regions of both male and female mice; 3) serum corticosterone and the expression of corticosterone receptors in the PVH were elevated in males but not in females; 4) the activation of the CRFR2 signal in the PVT and PVH brain regions differed by sex: the expression of CRFR2 was upregulated in male mice, and the phosphorylation of protein kinase B (AKT) and cAMP-response element binding protein (CREB) was significantly reduced; and 5) the cold-evoked eating behavior of male mice was abolished when CRFR2 in the PVT was knocked down. In summary, we conclude that male mice are more sensitive to cold stress than are female mice. The CRFR2/AKT/CREB signaling pathway in the PVT and PVH may mediate sex differences in the eating behavior of cold-exposed mice.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"169-176"},"PeriodicalIF":2.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NRG1-ErbB4 signaling in the cerebrospinal fluid-contacting nucleus regulates thermal pain in mice. 脑脊液接触核NRG1-ErbB4信号通路调节小鼠热痛。

IF 2.9 3区医学

Neuroscience Pub Date : 2025-02-06 Epub Date: 2024-12-27 DOI: 10.1016/j.neuroscience.2024.12.052

Yuhan Ding, Yao Yan, Wei Song, Ying Li, Jing Zhao, Bin Gui, Yijun Zhang, Licai Zhang

{"title":"NRG1-ErbB4 signaling in the cerebrospinal fluid-contacting nucleus regulates thermal pain in mice.","authors":"Yuhan Ding, Yao Yan, Wei Song, Ying Li, Jing Zhao, Bin Gui, Yijun Zhang, Licai Zhang","doi":"10.1016/j.neuroscience.2024.12.052","DOIUrl":"10.1016/j.neuroscience.2024.12.052","url":null,"abstract":"The cerebrospinal fluid-contacting nucleus(CSF-contacting nucleus) is a pair of unique nuclei in the brain parenchyma which has long been demonstrated to play an important role in pain signal processing. However, the mechanisms by which the CSF-contacting nucleus intervenes in pain is unclear. The NRG1-ErbB4 signaling plays an important role in the nervous system and has been shown to be involved in the regulation of pain. Whether there is an involvement of NRG1-ErbB4 signaling in the regulation of pain in the CSF-contacting nucleus is currently unknown. Here, our works showed that c-Fos expression in the CSF-contacting nucleus was increased in response to incisional pain. The activation of the CSF-contacting nucleus by chemogenetics could induce thermal hyperalgesia in naive mice without effecting the pain in mice suffering from incision pain. The inhibition of the CSF-contacting nucleus alleviated incision pain, but had no effect on the pain response in naive mice. With immunofluorescence staining and Western blot, the NRG1-ErbB4 signaling in the CSF-contacting nucleus showed upregulated during the acute pain phase. And, activating NRG1-ErbB4 signaling in the CSF-contacting nucleus specifically by intracranial injection of drugs, the naïve mice displayed thermal hyperalgesia while inhibiting this signaling by intracranial injection could reverse the hyperalgesia caused by CSF-contacting nucleus activation, and execute an analgesic effect during the painful phase in mice. Our study suggested that the CSF-contacting nucleus plays a regulatory role in thermal pain in mice via NRG1-ErbB4 signaling.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":"132-141"},"PeriodicalIF":2.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to comments by P. Sun.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-30 DOI: 10.1016/j.neuroscience.2025.01.046

Richard Ambron

引用次数: 0

Association between occupational complexity and cognitive function in older adults from Brazil and Mexico.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-30 DOI: 10.1016/j.neuroscience.2025.01.051

Natalia Gomes Goncalves, Gabriela Mininel de Medeiros, Aline Ciciliati, Jaqueline Contrera Avila, Laiss Bertola, Cleusa Ferri, Rebeca Wong, Claudia Kimie Suemoto

{"title":"Association between occupational complexity and cognitive function in older adults from Brazil and Mexico.","authors":"Natalia Gomes Goncalves, Gabriela Mininel de Medeiros, Aline Ciciliati, Jaqueline Contrera Avila, Laiss Bertola, Cleusa Ferri, Rebeca Wong, Claudia Kimie Suemoto","doi":"10.1016/j.neuroscience.2025.01.051","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.051","url":null,"abstract":"More complex occupations during adulthood may be associated with better cognition in later life. We used data from the Brazilian Longitudinal Study of Aging (ELSI) and the Mexican Health and Aging Study (MHAS) to investigate the association between occupational complexity and cognitive function. Using a regression-based approach, participants were classified as cognitively impaired or not. Occupation was categorized into four levels using the 2008 International Standard of Classification of Occupations. We used logistic regression models for separate and pooled analysis. The odds of cognitive impairment decreased with higher occupation skill levels in the ELSI, but this trend was not seen in the MHAS, where the highest skill level was not associated with cognitive impairment. ELSI participants had a lower probability of cognitive impairment compared to MHAS participants with the same occupation skill level. The results of this study suggest that programs addressing the negative consequences of lower-complexity occupations need to be tailored to specific regional contexts, considering their unique socioeconomic, cultural, and occupational landscapes.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of SUMOylation exacerbates neurological dysfunction and delays hematoma clearance after intracerebral hemorrhage in mice.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.062

Keita Kinoshita, Keisuke Ushida, Yuma Hirata, Shunya Tsujita, Natsuko Hitora-Imamura, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki

{"title":"Inhibition of SUMOylation exacerbates neurological dysfunction and delays hematoma clearance after intracerebral hemorrhage in mice.","authors":"Keita Kinoshita, Keisuke Ushida, Yuma Hirata, Shunya Tsujita, Natsuko Hitora-Imamura, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki","doi":"10.1016/j.neuroscience.2025.01.062","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.062","url":null,"abstract":"Intracerebral hemorrhage is a kind of hemorrhagic stroke resulting from bleeding in the brain parenchyma. SUMOylation is one of post-translational protein modifications based on covalent binding of small ubiquitin-like modifier (SUMO) peptide. Although SUMOylation has been reported to play neuroprotective roles in ischemic stroke, the role of SUMOylation in the pathology of intracerebral hemorrhage remains unclear. Here we addressed the relationship between SUMOylation and pathogenesis of intracerebral hemorrhage. For in vivo study, hemorrhage was induced in the striatum of male ICR mice by local injection of type VII collagenase. After induction of hemorrhage, there was a significant increase in the levels of SUMO2/3 protein conjugation in the brain, without accompanying significant changes in the levels of free SUMO2/3 protein and Sumo2/3 mRNA. When intracerebroventricular injection of TAK-981, an inhibitor of SUMOylation, was performed 3 d before hemorrhage induction, it delayed recovery of body weight, recovery of neurological functions and hematoma clearance. TAK-981 also suppressed CD36 expression in hematoma-associated microglia/macrophages. For in vitro study, phagocytic activity of microglial BV-2 cells was examined using erythrocytes obtained from mouse blood. We found that both TAK-981 and small interfering RNA-mediated knockdown of SUMO2/3 inhibited erythrophagocytosis by BV-2 cells. These results suggest that SUMOylation by SUMO2/3 promotes hematoma clearance via regulation of CD36 expression in microglia and contributes to the recovery from pathology of intracerebral hemorrhage.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of GABA, NSE, and miR-155 expression in patients with post-stroke epilepsy.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.057

Peng Wang, Jiankang Huang, Hongbo Wen, Xiuling Liang, Jie Wang, Pengyu Ding, Jie Ding

{"title":"Clinical significance of GABA, NSE, and miR-155 expression in patients with post-stroke epilepsy.","authors":"Peng Wang, Jiankang Huang, Hongbo Wen, Xiuling Liang, Jie Wang, Pengyu Ding, Jie Ding","doi":"10.1016/j.neuroscience.2025.01.057","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.057","url":null,"abstract":"This study investigated the clinical predictive value of cerebrospinal fluid (CSF) γ-aminobutyric acid (GABA) and serum neuron-specific enolase (NSE) and microRNA-155 (miR-155) for post-stroke epilepsy (PSE) in patients with cerebral infarction (CI). A total of 69 CI patients with PSE and 84 with non-post-stroke epilepsy (N-PSE) were retrospectively enrolled, with their clinical baseline data (CI type) and the National Institute of Health Stroke Scale (NIHSS) score collected. CSF GABA and serum NSE and miR-155 expression levels were determined, with their clinical value further assessed. The results showed that the proportions of patients with cardiogenic CI, multiple infarcts, and cortical involvement and NIHSS score in PSE patients were higher than those in N-PSE patients. CSF GABA was lowly expressed and serum NSE and miR-155 were highly expressed in PSE patients. The NIHSS score negatively correlated with GABA and positively correlated with NSE and miR-155. GABA [area under the curve (AUC) = 0.906], NSE (AUC = 0.908), miR-155 (AUC = 0.862) and their combined detection (AUC = 0.963) all had certain value in the occurrence of PSE in CI patients, with their combined detection showing higher AUC than that of single detection. Briefly, CSF GABA was reduced while serum NSE and miR-155 were elevated in PSE patients. GABA and NSE combined with miR-155 had high diagnostic value for PSE occurrence in CI patients. Lowly-expressed GABA or highly-expressed NSE and miR-155 were independent risk factors for PSE in CI patients, which could provide effective guidance for the clinical diagnosis and management of PSE.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A temporal-spatial feature fusion network for emotion recognition with individual differences reduction.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.049

Benke Liu, Yongxiong Wang, Zhe Wang, Xin Wan, Chenguang Li

{"title":"A temporal-spatial feature fusion network for emotion recognition with individual differences reduction.","authors":"Benke Liu, Yongxiong Wang, Zhe Wang, Xin Wan, Chenguang Li","doi":"10.1016/j.neuroscience.2025.01.049","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.049","url":null,"abstract":"Purpose: In the context of EEG-based emotion recognition tasks, a conventional strategy involves the extraction of spatial and temporal features, subsequently fused for emotion prediction. However, due to the pronounced individual variability in EEG and the constrained performance of conventional time-series models, cross-subject experiments often yield suboptimal results. To address this limitation, we propose a novel network named Time-Space Emotion Network (TSEN), which capitalizes on the fusion of spatiotemporal information for emotion recognition.Methods: Diverging from prior models that integrate temporal and spatial features, our network introduces a Convolutional Block Attention Module (CBAM) during spatial feature extraction to judiciously allocate weights to feature channels and spatial positions. Furthermore, we bolster network stability and improve domain adaptation through the incorporation of a residual block featuring Switchable Whitening (SW). Temporal feature extraction is accomplished using a Temporal Convolutional Network (TCN), ensuring elevated prediction accuracy while maintaining a lightweight network structure.Results: We conduct experiments on the preprocessed DEAP dataset. Ultimately, the average accuracy for arousal prediction is 0.7032 with a variance of 0.0876, and the F1 score is 0.6843. For valence prediction, the accuracy is 0.6792 with a variance of 0.0853, and the F1 score is 0.6826.Conclusion: TSEN exhibits high accuracy and low variance in cross-subject emotion prediction tasks, effectively reducing individual differences among different subjects. Additionally, TSEN has a smaller parameter count, enabling faster execution.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-29 DOI: 10.1016/j.neuroscience.2025.01.061

Dhanshree Nibrad, Amit Shiwal, Manasi Tadas, Raj Katariya, Mayur Kale, Nandkishor Kotagale, Milind Umekar, Brijesh Taksande

{"title":"Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders.","authors":"Dhanshree Nibrad, Amit Shiwal, Manasi Tadas, Raj Katariya, Mayur Kale, Nandkishor Kotagale, Milind Umekar, Brijesh Taksande","doi":"10.1016/j.neuroscience.2025.01.061","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.061","url":null,"abstract":"Mitochondrial dysfunction is a pivotal factor in the pathogenesis of neurodegenerative disorders, driving neuronal degeneration through mechanisms involving oxidative stress, impaired energy production, and dysregulated calcium homeostasis. Agmatine, an endogenous polyamine derived from arginine, has garnered attention for its neuroprotective properties, including anti-inflammatory, anti-oxidative, and antiapoptotic effects. Recent studies have highlighted the potential of agmatine in preserving mitochondrial function and mitigating neurodegeneration, making it a promising candidate for therapeutic intervention. One of the key mechanisms by which agmatine exerts its neuroprotective effects is through the maintenance of mitochondrial homeostasis. Agmatine has been shown to modulate mitochondrial dynamics, promoting mitochondrial fusion and fission balance essential for cellular energy metabolism and signaling. Moreover, agmatine acts as a regulator of mitochondrial permeability transition pore (mPTP) opening, preventing excessive calcium influx and subsequent mitochondrial dysfunction. Despite promising findings, challenges such as optimizing agmatine's pharmacokinetics, determining optimal dosing regimens, and elucidating its precise molecular targets within mitochondria remain to be addressed. Future research directions should focus on developing targeted delivery systems for agmatine, investigating its interactions with mitochondrial proteins, and conducting well-designed clinical trials to evaluate its therapeutic efficacy and safety profile in neurodegenerative disorders. Overall, agmatine emerges as a novel therapeutic agent with the potential to modulate mitochondrial homeostasis and alleviate neurodegenerative pathology, offering new avenues for treating these debilitating conditions.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public perceptions of brain health in young and middle-aged adults in Cuba: Opportunities for intervention.

IF 2.9 3区医学

Neuroscience Pub Date : 2025-01-28 DOI: 10.1016/j.neuroscience.2025.01.052

Yunier Broche-Pérez, Zoylen Fernández-Fleites, Diego D Díaz-Guerra, Marena de la C Hernández-Lugo, Carlos Ramos-Galarza

{"title":"Public perceptions of brain health in young and middle-aged adults in Cuba: Opportunities for intervention.","authors":"Yunier Broche-Pérez, Zoylen Fernández-Fleites, Diego D Díaz-Guerra, Marena de la C Hernández-Lugo, Carlos Ramos-Galarza","doi":"10.1016/j.neuroscience.2025.01.052","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.01.052","url":null,"abstract":"Understanding brain health is increasingly important, particularly in light of growing public health challenges related to neurological and psychiatric conditions. These include the rising prevalence of mental health disorders, such as depression and anxiety, as well as neurodegenerative diseases like Alzheimer's and Parkinson's. Lifestyle factors, including stress, poor diet, and insufficient physical activity, also significantly impact cognitive function. Exploring the perceptions and awareness of brain health among young and middle-aged adults is crucial to developing effective educational programs and awareness campaigns tailored to their specific needs. This study aimed to examine the perceptions and awareness of brain health among Cuban youth, focusing on the factors that shape their understanding and attitudes toward brain well-being. A cross-sectional online survey was conducted, with 1,049 participants voluntarily completing the questionnaire. Using \"The Global Brain Health Survey,\" we assessed participants' conceptions of brain health and analyzed associations between demographic variables and brain health knowledge through logistic regression. Our findings revealed that the social environment was viewed as the most significant factor influencing brain health. Other factors, such as profession, genetics, income, and nutrition, were considered important but to a lesser degree. While participants were generally aware of conditions like Alzheimer's disease and depression, there was a notable gap in understanding the cognitive implications of chronic diseases such as hypertension and diabetes, which are prevalent in Cuba. These insights highlight the need for targeted public health initiatives and educational campaigns that promote healthier behaviors and community support, particularly among young adults.","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0