Neuroscience最新文献

{"title":"Dose duration effect of concurrent and synchronized motor cortex theta burst stimulation and upper-limb neuromuscular electrical stimulation","authors":"Na Cao ,&nbsp;Atsushi Sasaki ,&nbsp;Milos R. Popovic ,&nbsp;Kimitaka Nakazawa ,&nbsp;Matija Milosevic","doi":"10.1016/j.neuroscience.2025.04.047","DOIUrl":"10.1016/j.neuroscience.2025.04.047","url":null,"abstract":"<div><div>Intermittent theta burst stimulation (iTBS) can induce rapid cortical facilitation, while neuromuscular electrical stimulation (NMES) can activate sensorimotor networks to excite the central nervous system. Application of iTBS and NMES delivered concurrently at a synchronized 50 Hz frequency was recently shown to elicit greater but transient corticospinal facilitation compared to each intervention. Our current study aimed to investigate the dose-duration neuromodulation effects of concurrent and synchronized associative stimulation using iTBS-NMES. A single dose consisted of 600 pulses of iTBS applied simultaneously with 50 Hz NMES for 2 s ON/8s OFF over 192 s. Four interventions were tested on separate days in eleven able-bodied individuals: iTBS600-NMES (one dose), iTBS1200-NMES (two doses), iTBS1800-NMES (three doses), and iTBS1800 (control intervention consisting of three iTBS-alone doses without NMES). Single-pulse transcranial magnetic stimulation (TMS) of motor cortex was used to evaluate corticospinal excitability through motor evoked potentials (MEP). Paired-pulse TMS short-interval intracortical inhibition (SICI) was used to evaluate intracortical inhibition, and maximum motor responses (M_max) were elicited by radial nerve stimulation to monitor fatigue. Assessments were completed before, immediately after, and every 10 min for total 30 min after each intervention. Our results showed significant MEP facilitation for at least 30 min only after iTBS1800-NMES intervention, while the iTBS1800 control intervention was ineffective. SICI and M_max responses were not affected by any intervention. Our findings demonstrate that increased iTBS-NMES dose-duration extends corticospinal facilitation that likely involved the cumulative effect to overcome the homeostatic threshold with repetitive synchronized activation of cortical and peripheral inputs at the subcortical level.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 253-262"},"PeriodicalIF":2.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERPs evidence of multisensory integration deficits in spinal cord injury","authors":"Roberta Vastano ,&nbsp;Marcello Costantini ,&nbsp;Eva Widerstrom-Noga","doi":"10.1016/j.neuroscience.2025.04.048","DOIUrl":"10.1016/j.neuroscience.2025.04.048","url":null,"abstract":"<div><div>Spinal cord injury (SCI) is associated with deficits in multisensory integration—the ability to synthesize cross-modal information. This study explores the neural mechanisms underlying these deficits using EEG and a detection task incorporating unisensory and multisensory stimuli: audio-visual, visuo-tactile, and audio-tactile. Behaviorally, participants with SCI showed reduced multisensory integration across all modalities, consistent with prior findings. Neurally, ERPs were analyzed in three conditions: audio-tactile (N100, P200), visuo-tactile (P170), and audio-visual (P100, N200). Higher ERP amplitudes for multisensory versus unisensory stimuli were only observed in the control group, whereas the SCI group showed similar amplitudes across both. In the SCI group, multisensory ERPs were significantly lower for audio-tactile P200, visuo-tactile P170, and audio-visual P100, indicating a deficit in multisensory processing. Auditory ERPs were preserved in SCI participants, while visual and tactile responses were reduced, suggesting an auditory dominance post-SCI. Cluster-based analysis on residual effects showed that the control group exhibited greater multisensory gain compared to SCI participants, with significant centro-parietal clusters observed for audio-tactile (50–100 ms, 120–180 ms, 300–500 ms), visuo-tactile (80–120 ms, 120–180 ms), and audio-visual (280–480 ms) residual effects.</div><div>Overall, these results highlight that SCI has detrimental effects not only on the motor system, but also on the ability to process multisensory information. This study advances our understanding of multisensory integration mechanisms following sensorimotor deficits and highlights the need for targeted interventions to address multisensory impairments in this population.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 263-276"},"PeriodicalIF":2.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of magnetic resonance structural imaging to identify disease progression in patients with mild cognitive impairment: A voxel-based morphometry and surface-based morphometry study.","authors":"Zihan Zhang, Jiaxuan Peng, Yuan Shao, Xiaotian Li, Yuyun Xu, Qiaowei Song, Yelei Xie, Zhenyu Shu","doi":"10.1016/j.neuroscience.2025.04.031","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.04.031","url":null,"abstract":"<p><p>Voxel-based morphometry (VBM) and surface-based morphometry (SBM) based on magnetic resonance structural imaging were used to identify disease progression in mild cognitive impairment (MCI) patients. A retrospective analysis was conducted on 154 MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, with 62 patients classified into the progressive MCI (pMCI) group and 92 patients into the stable MCI (sMCI) group. VBM and SBM were employed to identify structural differences between sMCI and pMCI patients, and differential features were extracted for model construction. The logistic regression method was used to establish relevant index models, and the DeLong test was used to compare the diagnostic performance of the different models. Additionally, 51 patients from the National Alzheimer's Coordinating Center (NACC) database were used as an external validation set to further validate the clinical efficacy of the model. Significant structural differences between pMCI and sMCI patients were revealed through VBM and SBM analyses. Volume reductions were observed in the frontal and temporal lobes, and cortical thinning occurred in the left inferior and superior parietal cortices. Reduced gyrification was observed in the bilateral insular gyrus. The structural joint model, which combines volume and cortical indices, demonstrated higher diagnostic accuracy compared to the joint scale index model that combines the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA) indices. The findings indicate that combined VBM and SBM analysis offers a sensitive and noninvasive approach to detect structural biomarkers of MCI progression, providing a practical tool for early risk stratification and personalized clinical management.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the relative abundance of butyrate-producing and mucin-degrading taxa and Parkinson’s disease","authors":"C. Rust ,&nbsp;L.L. van den Heuvel ,&nbsp;S. Bardien ,&nbsp;J. Carr ,&nbsp;E. Pretorius ,&nbsp;S. Seedat ,&nbsp;S.M.J. Hemmings","doi":"10.1016/j.neuroscience.2025.04.050","DOIUrl":"10.1016/j.neuroscience.2025.04.050","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is a neurodegenerative disorder characterised by motor and non-motor symptoms. Recent evidence suggests a role for gut microbiome composition and diversity in PD aetiology. This study aimed to explore the association between the gut microbiome and PD in a South African population. Gut microbial sequencing data (cases: <em>n</em> = 16; controls: <em>n</em> = 42) was generated using a 16S rRNA gene (V4) primer pair. Alpha- and beta-diversity were calculated using QIIME2, and differential abundance of taxa was evaluated using Analysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC). Beta-diversity was found to differ significantly between cases and controls, with depletion in the relative abundance of <em>Faecalibacterium</em>, <em>Roseburia</em>, <em>Dorea</em>, and <em>Veillonella</em>, and enrichment of the relative abundance of <em>Akkermansia</em> and <em>Victivallis</em>. Our study found a reduction in butyrate-producing bacteria (e.g. <em>Faecalibacterium</em> and <em>Roseburia</em>) and an increase in mucin-degrading bacteria (<em>Akkermansia</em>) in PD cases compared to controls. These alterations might be associated with heightened gut permeability and inflammation. Longitudinal studies should address the question of whether these microbiome differences are a risk factor for, or are consequent to, the development of PD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 149-154"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hif-1α regulation of the Tet1-β-catenin-Dicer1-miRNAs pathway is involved in depression-like behavior in prenatal hypoxic male offspring","authors":"Zejun Zhao ,&nbsp;Hongtao Zeng ,&nbsp;Xi Yu ,&nbsp;Yajun Shi ,&nbsp;Yan Zhao ,&nbsp;Yueyang Song ,&nbsp;Lingjun Li ,&nbsp;Qinqin Gao ,&nbsp;Miao Sun ,&nbsp;Bin Wang","doi":"10.1016/j.neuroscience.2025.04.051","DOIUrl":"10.1016/j.neuroscience.2025.04.051","url":null,"abstract":"<div><div>Prenatal hypoxia (PH) is a common complication of pregnancy, and it is strongly associated with psychiatric disorders such as depression and anxiety in the offspring. However, how prenatal hypoxia contributes to psychiatric disorders in the offspring is unclear. In this study, we established a model of prenatally hypoxic mice, where pregnant females were treated with hypoxia (10.5% O₂) during gestational days 12.5–17.5, while controls (CON) were kept in a normoxic (21% O₂) environment. Compared to CON offspring, PH male offspring exhibited depression-like behaviors. Prenatal hypoxia resulted in significantly higher protein level of the oxygen-sensitive subunit of hypoxia-inducible factor (Hif-1α) and lower levels of Ten-eleven translocated methylcytosine dioxygenase 1 (Tet1), β-catenin, and downstream Dicer1-miRNAs pathway associated with depressive behavior. Mechanistically, prenatal hypoxia leads to Hif-1α binding to Tet1, which inhibits β-catenin binding to Tet1, leading to an increase in ubiquitination-dependent degradation of β-catenin and down-regulation of the β-catenin-Dicer1-miRNAs pathway. In addition, administration of the β-catenin-specific agonist SKL2001 or overexpressing virus ameliorated the down-regulation of β-catenin-Dicer1-miRNAs signaling and depression-like behavior in PH male offspring. These findings suggest that Hif-1α and β-catenin competition for Tet1 binding is involved in depression-like behaviors in PH offspring, and this study provides important data on the molecular mechanisms by which prenatal hypoxia might be involved in adult psychiatric disorders of fetal origin.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 155-166"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamatergic synaptic plasticity in medial vestibular nuclei during vestibular compensation","authors":"Yang-Xun Zhang ,&nbsp;Lu-Yao Li ,&nbsp;Yue Xing ,&nbsp;Ao-Xue Chen ,&nbsp;Shu-Tao Xie ,&nbsp;Hong-Zhao Li ,&nbsp;Qi-Peng Zhang ,&nbsp;Xiao-Yang Zhang ,&nbsp;Xu Yang ,&nbsp;Wing-Ho Yung ,&nbsp;Jing-Ning Zhu","doi":"10.1016/j.neuroscience.2025.04.049","DOIUrl":"10.1016/j.neuroscience.2025.04.049","url":null,"abstract":"<div><div>Vestibular compensation, the spontaneous recovery from vestibular dysfunction following unilateral vestibular loss, serves as a valuable model for investigating post-lesion plasticity in the adult central nervous system. Elucidating the mechanisms underlying vestibular compensation also offers promising therapeutic avenues for treating vestibular disorders. While most studies have focused on the dynamics of GABAergic synaptic plasticity and intrinsic cellular adaptations in the ipsilesional medial vestibular nucleus (MVN) after unilateral labyrinthectomy (UL), the role of glutamatergic synaptic plasticity in this process remains largely unexplored. Here, we employed Golgi staining, immunofluorescence, whole-cell patch-clamp recordings, and behavioral assessments to examine the structural and functional dynamics of glutamatergic synapses during vestibular compensation. Our results reveal rapid structural and functional plasticity of glutamatergic transmission in response to UL. Specifically, dendritic spine density and morphology in the ipsilesional MVN recovered to baseline levels within 6 to 24 h post-UL. Furthermore, UL-induced postsynaptic depression of glutamatergic synaptic strength, reflected by a reduced AMPA/NMDA ratio, was reversed within 24 h, likely due to an upregulation of Ca²⁺-permeable AMPA receptors. In contrast, presynaptic glutamate release probability, as indicated by a reduced frequency of spontaneous excitatory postsynaptic currents, was not fully compensated during this period. These results suggest that while presynaptic properties recover more slowly in ipsilesional MVN neurons following UL, postsynaptic glutamatergic transmission undergoes rapid structural and functional reorganization. The findings highlight glutamatergic synaptic plasticity as a critical driver for vestibular compensation and suggest that pharmacological interventions targeting these mechanisms may accelerate functional recovery, offering potential therapeutic avenues for vestibular disorders.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 213-222"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rag1−/− mice with T and B lymphocyte deficiency exhibit milder retinal inflammatory response and retinal ganglion cell injury after optic nerve crush","authors":"Ying Cheng ,&nbsp;Danting Lin ,&nbsp;Shen Wu ,&nbsp;Xuejing Yan ,&nbsp;Qian Liu ,&nbsp;Ningli Wang ,&nbsp;Jingxue Zhang","doi":"10.1016/j.neuroscience.2025.04.046","DOIUrl":"10.1016/j.neuroscience.2025.04.046","url":null,"abstract":"<div><div>Bourgeoning literature verified the essential contribution of neuroinflammation in optic nerve injury, here, we aim to investigate the effect of lymphocyte deficiency on retinal ganglion cells (RGCs) survival after optic nerve crush (ONC). 48 wide type (WT) and 48 Rag1^−/− mice were used to establish the ONC model. AAV2-hSyn1-eGFP was employed to inject into the vitreous body to transfect RGCs 4 weeks before ONC modeling, the confocal scanning laser ophthalmoscopy was utilized to visualize the RGCs in vivo. RBPMS, Iba-1 and GFAP expression were detected by immunofluorescence. The expression of retinal glial biomarkers was detected by qRT-PCR, and the protein expression of occludin and CD3 was detected by WB. Electroretinography and optomotor response were used to evaluate the visual function. Our results showed that a milder RGC loss and GCC thickness decrease were found in Rag1^−/− mice than in WT mice after ONC in vivo and in vitro (<em>p</em> &lt; 0.05). The morphologic and molecular feature analyses of retinal glial cells showed that the lack of lymphocytes significantly inhibited the number and activation level of microglia after ONC (<em>p</em> &lt; 0.05). Besides, Occludin was significantly decreased and CD3 was upregulated at week 4 after ONC in WT mice compared with Rag1^−/− mice (<em>p</em> &lt; 0.01). Visual function assessment showed a better visual condition in Rag1^−/− mice with ONC at week 4 (<em>p</em> &lt; 0.05). Altogether, Rag1^−/− mice with lymphocyte deficiency exhibit less RGC loss, milder retinal glial activation and better visual function when compared with WT mice after ONC.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 129-137"},"PeriodicalIF":2.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal thyroid hormone deficiency leads to oxidative stress-induced neuronal damage and activation of astrocytes in rat hippocampus: Neuroprotective effect of exercise","authors":"Zohreh Zare ,&nbsp;Sam Zarbakhsh ,&nbsp;Moslem Mohammadi","doi":"10.1016/j.neuroscience.2025.04.042","DOIUrl":"10.1016/j.neuroscience.2025.04.042","url":null,"abstract":"<div><div>Thyroid hormones play a crucial role in proper brain development. This study examined the effects of developmental thyroid hormone deficiency on neuronal survival, glial fibrillary acidic protein (GFAP)-positive cells, and oxidative stress biomarkers in the hippocampus of congenital hypothyroid rats. The effectiveness of treadmill exercise in attenuating oxidative stress-induced neuronal damage and astrocyte activation was also evaluated. Pregnant Wistar rats in the hypothyroid group received propylthiouracil in their drinking water from gestational day 6 until weaning, while control dams received only tap water. Then, male offspring from both groups were further divided into two sub-groups: with or without four weeks of treadmill exercise. After sacrifice, the right hemispheres were processed for cresyl violet staining and immunohistochemistry, while the left hippocampi were used for biochemical assays. Results showed a reduced number of neurons and an increased number of GFAP-positive cells in the CA1 region of hypothyroid rats, with no significant changes in the CA3 region. Additionally, congenital hypothyroidism was associated with increased malondialdehyde levels, decreased glutathione levels, and reduced superoxide dismutase and catalase activity in the hippocampus. Treadmill exercise reduced astrocyte activation and protected neurons by inhibiting oxidative stress. Collectively, our results indicate that congenital thyroid hormone deficiency triggers astrocyte activation and compromises neuronal survival in the CA1 region by inducing oxidative stress. Exercise may serve as a beneficial supplementary treatment for attenuating oxidative stress-induced neuronal damage in congenital hypothyroidism.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 96-104"},"PeriodicalIF":2.9,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation response index as a predictor of 3-month functional outcomes in acute ischemic stroke patients following intravenous thrombolysis","authors":"Xinxin Chen ,&nbsp;Yuyi Xie ,&nbsp;Chao Yu ,&nbsp;Zhi Li ,&nbsp;Mayila Abuduaini ,&nbsp;Di Zhang ,&nbsp;Lian Zuo","doi":"10.1016/j.neuroscience.2025.04.043","DOIUrl":"10.1016/j.neuroscience.2025.04.043","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation is a critical factor in the pathogenesis of acute ischemic stroke (AIS). The systemic inflammation response index (SIRI), which combines three inflammatory markers, serves as a comprehensive, accessible, and cost-effective tool for assessing inflammation. However, the potential of SIRI to predict the 3-month outcomes of AIS patients following intravenous thrombolysis (IVT) has not been fully explored. Given the urgency of improving patient prognostication and treatment strategies, this study aims to assess the predictive value of SIRI for AIS prognosis at the 3-month mark, providing insights that could enhance clinical decision-making and guide future therapeutic approaches.</div></div><div><h3>Methods</h3><div>AIS patients who received IVT from December 2020 to June 2024 were enrolled. The Modified Rankin Scale (mRS) was utilized to evaluate clinical outcomes. Propensity score matching (PSM) and logistic regression analysis were performed to investigate the association between SIRI and the 3-month prognosis in AIS patients.</div></div><div><h3>Results</h3><div>A total of 559 AIS patients were enrolled in the study, with 433 (77.5 %) experiencing poor outcome. Among the 83 matched patient pairs following propensity score matching (PSM), a significant association was observed between the SIRI and clinical outcomes (OR, 2.27; 95 % CI, 1.42–3.65; p &lt; 0.001). The optimal cutoff value for predicting outcomes was identified as a SIRI level of 0.856, achieving sensitivity and specificity of 84.1 % and 51.7 %, respectively.</div></div><div><h3>Conclusions</h3><div>Elevated SIRI levels are indicative of an increased likelihood of poor outcomes following IVT in AIS patients, suggesting that SIRI could serve as a valuable prognostic biomarker for patient recovery.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 234-240"},"PeriodicalIF":2.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin prevents single prolonged stress-induced posttraumatic stress disorder and neurochemical changes via antioxidant, antiinflammatory and antiapoptotic mechanisms in rats","authors":"Mega Obukohwo Oyovwi ,&nbsp;Ejime A. Chijiokwu ,&nbsp;Arientare Rume Rotu ,&nbsp;Ejayeta Jeroh ,&nbsp;Paul Chinwuba ,&nbsp;Benneth Ben-Azu ,&nbsp;Esthinsheen Osirim ,&nbsp;Eze Kingsley Nwangwa","doi":"10.1016/j.neuroscience.2025.04.036","DOIUrl":"10.1016/j.neuroscience.2025.04.036","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) is a debilitating condition characterized by neurochemical imbalances and behavioral disruptions. Emerging evidence suggests that quercetin, a naturally occurring flavonoid, may possess neuroprotective properties. This study investigates the potential effects of quercetin on neurochemical dynamics associated with single prolonged stress (SPS)-induced PTSD in rats. Male Sprague-Dawley rats were subjected to the SPS protocol to induce PTSD-like symptoms. Following SPS exposure, rats were randomly assigned to either a quercetin treatment group or a vehicle control group. Neurochemical analysis was performed post-treatment, including assessment of neurotransmitter concentrations (e.g., serotonin, norepinephrine, dopamine) and inflammatory markers (e.g., TNF-α, IL-1β) in relevant brain tissues. Behavioral assessments were also conducted to correlate neurochemical changes with PTSD-like symptoms. Preliminary findings suggest that quercetin treatment, particularly at 20 mg/kg dosages, resulted in a partial modulation of neurochemical dysregulation related to PTSD. Specifically, quercetin administration attenuated the stress-induced regional alterations in neurotransmitter levels, including increased dopamine and serotonin levels, and decreased markers of neuroinflammation in the studied brain regions compared to the control group. These changes were associated with improvements in anxiety-like and depressive behavior alongside increased cognitive performance. Quercetin shows potential to improve the neurochemical imbalances linked to PTSD in a rat model. Further studies are needed to confirm these findings and investigate the exact mechanisms of action, as well as the therapeutic potential of quercetin for individuals with PTSD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"576 ","pages":"Pages 199-212"},"PeriodicalIF":2.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}