Neuroscience最新文献

{"title":"Development and validation of an open-source hand laterality judgement task for in-person and online studies","authors":"Marcos Moreno-Verdú,&nbsp;Siobhán M. McAteer,&nbsp;Baptiste M. Waltzing,&nbsp;Elise E. Van Caenegem,&nbsp;Robert M. Hardwick","doi":"10.1016/j.neuroscience.2025.02.056","DOIUrl":"10.1016/j.neuroscience.2025.02.056","url":null,"abstract":"<div><div>The Hand Laterality Judgement Task (HLJT) is considered a measure of the ability to manipulate motor images. The ‘biomechanical constraints’ effect (longer reaction times for hand rotations towards anatomically difficult versus biomechanically easier movements) is considered the behavioural hallmark indicating motor imagery is being used. Previous work has used diverse HLJT paradigms, and there is no standardized procedure for the task. We developed an open-source, freely available version of the HLJT in PsychoPy2, which needs no programming skills and is highly customisable. Some studies suggest responding to the HLJT with the hands may interfere with performance, which would limit practical application of the task. We examined this potential issue using in-person and online versions. For the in-person version, 40 right-footed/handed individuals performed the HLJT with their feet or bimanually (N = 20 each). For the online version, 60 right-handed individuals performed the task bimanually or unimanually (N = 20 each). Bayesian mixed-effect analyses quantified the evidence for and against equivalence within and between the in-person and online versions. Both versions replicated previously described behavioural phenomena, including effects of angle, hand view, and the ‘biomechanical constraints’ effect. While responding with different effectors modified overall reaction times, it did not interact with other factors analysed, and did not affect accuracy or the ‘biomechanical constraints’ effect. There was also evidence for equivalence between in-person and online bimanual groups for all measures. We conclude that this open-source, standardized HLJT protocol (available at <span><span>https://osf.io/8h7ec/</span><svg><path></path></svg></span>) can reliably detect previously identified effects and works equally well in-person or online.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 93-107"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-124-mediated temozolomide sensitivity and DNA repair modulation in Glioblastoma Multiforme","authors":"Maryam Mafi Golchin ,&nbsp;Ehsan Arefian ,&nbsp;Zahra Fekrirad ,&nbsp;Gholamreza Hashemi Tabar","doi":"10.1016/j.neuroscience.2025.03.010","DOIUrl":"10.1016/j.neuroscience.2025.03.010","url":null,"abstract":"<div><div>Glioblastoma Multiforme (GBM) is the most frequent and invasive primary malignant brain tumor. One approach to improve the effectiveness of GBM treatment is the combination of miRNA-targeted therapy with TMZ. This study aimed to assess the effect of miR-124 overexpression on TMZ resistance in GBM cell lines. Additionally, we examined how miR-124 overexpression affects the expression of genes involved in DNA repair processes. We conducted a bioinformatics prediction for target genes of miR‑124‑3p and then overexpressed miR-124 in U-87 and U-251 cell lines through lentiviral transduction. Sixty genes were identified as potential targets of miR-124-3p, which revealed overlap among 504 target mRNAs and upregulated genes across four GEO datasets. <em>PRRX1</em>, <em>ETS</em>, <em>VIM</em>, and <em>PTBP1</em> genes were selected based on their contributions to DNA repair and related processes such as autophagy including <em>Beclin-1</em> and <em>Atg-5</em>. The MTT assay results showed that only the U87 cell line overexpressing miR-124 exhibited significantly greater sensitivity to TMZ treatment. The qRT-PCR analysis revealed a significant reduction in mRNA levels of all DNA repair-related genes and two autophagy-related genes in both cell lines. The results might indicate that after TMZ-induced genomic damage, cells activate the DNA repair pathways, ultimately leading to the development of resistance. In the context of TMZ treatment, autophagy is considered a protective process for cancer cells, and definitive proof of its association with the anti-cancer activity of miR-124 requires further supplementary tests. So, modulating DNA repair pathways with miR-124 could enhance the chemosensitivity of Glioma cells to TMZ.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"573 ","pages":"Pages 52-63"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant white matter function and structure in Rhegmatogenous retinal detachment: A study utilizing functional network clustering and TractSeg methods.","authors":"Yu Ji, Ben-Liang Shu, Zhuo-Er Dong, Bin Wei, Qin-Yi Huang, Lin Zhou, Hua Chai, Hao-Yu Yuan, Yi-Chong Duan, Li-Li Yao, Xiao-Rong Wu","doi":"10.1016/j.neuroscience.2025.03.013","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.03.013","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have documented abnormal functional changes in the visual pathways and gray matter regions related to vision in Rhegmatogenous retinal detachment (RRD) patients. However, the extent of alterations in the functional and structural characteristics of white matter (WM) in these patients remains insufficiently understood.</p><p><strong>Methods: </strong>In this study, we employed functional clustering networks and TractSeg methodologies to investigate the alterations in WM function and structure among patients with RRD. Subsequently, we applied a Support Vector Machine (SVM) algorithm to classify RRD patients and healthy controls (HCs).</p><p><strong>Results: </strong>Compared to HCs, patients with RRD exhibited a marked reduction in Functional Covariance Connectivity (FCC) between the Superior Temporal Network and the Cerebellar Network. Concurrently, there was an elevation in WM amplitude within the Anterior Corpus Callosum Network among RRD patients. Moreover, significant differences were identified in WM fiber bundles linked to visual and cognitive functions. Notably, the visual acuity of RRD patients displayed a significant positive correlation with the amplitudes of the Brainstem Network and the Cerebellar Network. The SVM classification based on WM7_amplitude achieved the highest AUC value of 0.6694.</p><p><strong>Conclusion: </strong>This study highlights abnormal changes in both the functional and structural integrity of WM in patients with RRD, which are likely directly linked to their cognitive and visual deficits. Furthermore, variations in the WM7_amplitude parameter may serve as a neurobiological marker for differentiating RRD patients from HCs. These findings offer profound insights into the underlying neural mechanisms contributing to the cognitive and visual impairments experienced by RRD patients.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subunit specific altered expression and activity of casein kinase 2 in the brain tissues resected from mesial temporal lobe epilepsy with hippocampal sclerosis patients & rodent temporal lobe epilepsy model","authors":"Priya Priya ,&nbsp;Arpna Srivastava ,&nbsp;Nitin Yadav ,&nbsp;Radhika Mittal ,&nbsp;Sneha Anand ,&nbsp;Jyotirmoy Banerjee ,&nbsp;Manjari Tripathi ,&nbsp;Poodipedi Sarat Chandra ,&nbsp;Ramesh Doddamani ,&nbsp;Mehar Chand Sharma ,&nbsp;Sanjeev Lalwani ,&nbsp;Fouzia Siraj ,&nbsp;Aparna Banerjee Dixit","doi":"10.1016/j.neuroscience.2025.03.001","DOIUrl":"10.1016/j.neuroscience.2025.03.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Mesial temporal lobe epilepsy (MTLE), is associated with dysregulated excitatory-inhibitory balance in the brain. Numerous enzymes, protein kinases, that are modulated through phosphorylation, have been linked with key processes involved in the pathogenesis of epilepsy. Therefore, in this study, we determined the subunit specific expression and activity of multi-subunit casein Kinase 2 (CK2) which influences NMDARs through phosphorylation events, in MTS patients as well as pilocarpine model of TLE.</div></div><div><h3>Methods</h3><div>mRNA expression of CK2 (α, α’, β) &amp; NR2B was measured by real time PCR and<!--> <!-->protein expression of CK2 (α, α’, β), NR2B, and NR2B Ser1480 were evaluated using western blotting and immunohistochemistry in experimental models of TLE and MTS patients. CK2 α and α’ activity was measured by kinase assay.</div></div><div><h3>Results</h3><div>Significant increase in CK2α’, CK2β, and NR2B mRNA expression were noted in chronic TLE rat model. Similarly, MTS patients displayed upregulated CK2α’ and CK2β expressions, but NR2B mRNA remained unchanged. CK2α’, CK2β, and NR2B Ser1480 protein expressions were higher in chronic TLE and MTS patients in relation to controls (p &lt; 0.05), as was kinase activity (p &lt; 0.05). In acute TLE rats, only NR2B protein expression was upregulated (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Our research demonstrated for the first time the upregulation of CK2α’ subunit and its increased kinase activity<!--> <!-->in resected brain samples from MTS patients as well as pilocarpine model of TLE. Altered expression and higher activity of CK2 α’ highlights subunit specific contribution, suggesting the modulation of NMDA receptors by Casein Kinase 2 may contribute to hyperexcitability in MTLE.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 108-121"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptin as a potential neuroprotective target in Parkinson’s Disease: Exploring its role in Neuroinflammation, oxidative Stress, and dopaminergic neurodegeneration","authors":"Vipul Sharma ,&nbsp;Bhat Zada Unjum Saqib ,&nbsp;Khadga Raj Aran","doi":"10.1016/j.neuroscience.2025.03.008","DOIUrl":"10.1016/j.neuroscience.2025.03.008","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is the second most common<!--> <!-->neurodegenerative disease, characterized by<!--> <!-->bradykinesia, resting tremor, stiffness, and postural instability<!--> <!-->resulting due to the progressive loss of<!--> <!-->dopaminergic neurons in the substantia nigra (SN). The pathophysiology of PD<!--> <!-->is extremely complex and involves mitochondrial dysfunction, oxidative stress, neuroinflammation, and disruption of protein homeostasis. Its progression is affected by both environmental and genetic factors, including mutations in the alpha-synuclein (SNCA), PTEN-induced kinase 1 (PINK1), and leucine-rich repeat kinase 2 (LRRK2) genes. Leptin, primarily secreted by the adipose tissue, has garnered significant interest for its involvement in neuroprotective mechanisms and potential role in the progression of PD. Its receptors located in the SN and hippocampus region indicate its role in neuronal survival and function. The role of leptin in the central nervous system (CNS) highlights its impact on neuroinflammation, oxidative stress, and synaptic plasticity. Recent studies indicate that through activation of Janus kinase/signal transducer and activator of transcription (JAK2/STAT3) and the phosphoinositide 3 kinase (PI3 K)/Akt pathways, leptin may exert a neuroprotective effect by preventing the degeneration of dopaminergic neurons, which marked as the hallmark in the pathophysiology of PD. Additionally, leptin’s interaction with neurotrophic factors and its ability to enhance synaptic plasticity highlight its vital role in preserving neuronal health. This review summarizes the role of leptin as a neuroprotective mechanism in PD and explores its potential role as a therapeutic target for treatment to enhance neuroprotection and clinical outcome, by addressing the neurodegenerative characteristics associated with PD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 134-144"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taking flight, the use of Drosophila melanogaster for neuroscience research in Uruguay","authors":"Gonzalo Budelli ,&nbsp;María José Ferreiro ,&nbsp;Carmen Bolatto","doi":"10.1016/j.neuroscience.2025.03.006","DOIUrl":"10.1016/j.neuroscience.2025.03.006","url":null,"abstract":"<div><div>The Sociedad de Neurociencias del Uruguay is celebrating its 30th anniversary, sustained by more than a century of neuroscience research in the country. During this time, different approaches and experimental organisms have been incorporated to study diverse aspects of neurobiology. One of these experimental animals, successfully used in a variety of biological fields, is the fruit fly <em>Drosophila melanogaster</em>. Although <em>Drosophila</em> has been a model organism for neuroscience research worldwide for many decades, its use in Uruguay for that purpose is relatively new and just taking flight. In this special issue article, we will describe some of the research lines that are currently using <em>Drosophila</em> for neuroscience studies, questioning a wide range of issues including thermoreception, neurodegenerative diseases such as Parkinson's, screening of bioactive compounds with a neuroprotective effect, and gene/protein function during development of the nervous system.</div><div>The consolidation of these research lines has been achieved due to unique features of <em>D. melanogaster</em> as an experimental model. We will review the advantages of using <em>Drosophila</em> to study neurobiology and describe some of its useful genetic tools. Advantages such as having powerful genetics, highly conserved disease pathways, a complete connectome, very low comparative costs, easy maintenance, and the support of a collaborative community allowing access to a vast toolkit, all make <em>D. melanogaster</em> an ideal model organism for neuroscientists in countries with low levels of investment in research and development. This review focuses on the strengths and description of useful techniques to study neurobiology using <em>Drosophila</em>, from the perspective of a Latin-American experience.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"573 ","pages":"Pages 104-119"},"PeriodicalIF":2.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture promotes oligodendrocyte differentiation and myelin repair in a rat model of vascular dementia: Investigation of the mechanism from NF-κB-mediated inflammation","authors":"Chang Liu ,&nbsp;Hongyu Yin ,&nbsp;Xiaoyu Chen ,&nbsp;Wenming Ban ,&nbsp;Guoqi Zhu ,&nbsp;Jingji Wang","doi":"10.1016/j.neuroscience.2025.03.002","DOIUrl":"10.1016/j.neuroscience.2025.03.002","url":null,"abstract":"<div><div>Myelin impairment is an important cause of cognitive impairment in vascular dementia (VD). Promoting myelin regeneration has become an important improvement strategy and oligodendrocytes are important targets. This study used a multiple microinfarctions (MMI)-induced VD rat model to reveal the mechanism of myelination of oligodendrocytes in the recovery of VD model, and to investigate the intervention mechanism of electroacupuncture (EA), an effective therapeutic for VD. Initially, our transcriptomic analysis identified 52 differentially expressed genes between the sham and MMI groups. These genes are primarily associated with axonal pathways, including the synaptic vesicle cycle, glutamatergic synapse, axon guidance, and sphingolipid metabolism. Compared with sham group, inflammation, impaired differentiation of oligodendrocyte precursor cells (OPCs) and myelin damage were remarkably observable in the hippocampus of MMI group, indicating the involvement of inflammation-regulated impairment of OPCs. Accordingly, pyrrolidinedithiocarbamate (PDTC), a NF-κB inhibitor could improve learning and memory impairment, reverse the hippocampal inflammation and impairment of OPCs differentiation, and decrease myelin damage in MMI rats. Importantly, EA could also improve learning and memory, attenuate the inflammatory response in the hippocampus and facilitate the differentiation of OPCs to aid in the repair of myelin damage in MMI rats. In conclusion, our data suggest that NF-κB activation is a prohibited factor for the myelin repair, while EA might reduce NF-κB activation and promote the differentiation of OPCs to repair the myelin damage in MMI rats.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 21-34"},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological and functional Characterization of a neonatal mouse model of intraventricular hemorrhage","authors":"Akanksha Mishra ,&nbsp;Bokun Cheng ,&nbsp;Aaina Singh Rathore ,&nbsp;Shreyas Singh ,&nbsp;Praveen Ballabh","doi":"10.1016/j.neuroscience.2025.03.007","DOIUrl":"10.1016/j.neuroscience.2025.03.007","url":null,"abstract":"<div><div>Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is a major neurological problem of premature infants that leads to white matter injury and posthemorrhagic hydrocephalus. There is no optimal treatment for IVH-induced complications. Several animal models of IVH have been developed, but they have significant limitations. We employed a one-day-old C57BL/6 mouse (P1) and injected hemolyzed whole blood or saline into both cerebral ventricles under hypothermia-induced anesthesia. The blood was obtained from one of the C57BL/6 inbred mouse strains. We evaluated a range of parameters, including apoptosis, cerebral inflammation, myelination, ventricle size, and neurobehavioral functions. The weight gain was comparable between blood- and saline-injected mouse pups. The ventricle size and head dimensions were larger in blood-injected pups compared to saline controls at P21 through P60. We demonstrated greater apoptotic cell death, neuronal degeneration, and microglia infiltration in the periventricular white matter of blood-treated pups relative to controls at P3 and P7. Myelination was reduced, and astrogliosis was increased in blood-injected mice relative to saline controls at P21. Post-hemorrhagic hydrocephalus was noted in blood-treated mice at both P21 and P60. Neurobehavior evaluation revealed motor and cognitive deficits in blood-injected animals relative to controls at P60. A comparison between hemolyzed and non-hemolyzed whole blood-treated pups showed that the hemolyzed blood produced more consistent hydrocephalus and reduction in myelination compared to non-hemolyzed blood injections. The study provides comprehensive analyses of a novel model of IVH that can be employed to understand the mechanisms and develop therapeutic strategies for white matter injury and hydrocephalus in IVH survivors.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 56-67"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: In vivo and in silico approaches","authors":"Md. Sakib Al Hasan ,&nbsp;Md. Shimul Bhuia ,&nbsp;Raihan Chowdhury ,&nbsp;Zakir Husain ,&nbsp;Md. Saifuzzaman ,&nbsp;Emon Mia ,&nbsp;Md. Showkoth Akbor ,&nbsp;Noshin Tasnim Yana ,&nbsp;Md. Amirul Islam ,&nbsp;Siddique Akber Ansari ,&nbsp;Irfan Aamer Ansari ,&nbsp;Md. Torequl Islam","doi":"10.1016/j.neuroscience.2025.03.004","DOIUrl":"10.1016/j.neuroscience.2025.03.004","url":null,"abstract":"<div><div>The citrus peel flavonoid tangeretin (TAN) has diverse biological activities, including antioxidant, anti-inflammatory, antitumor, hepatoprotective, and neuroprotective effects. This study investigates the sedative effects of TAN, in Swiss albino mice using <em>in vivo</em> and <em>in silico</em> approaches. TAN (10 and 20 mg/kg, i.p.) was administered alone and in combination with diazepam (DZP, 2 mg/kg, i.p.) and flumazenil (FLU, 0.1 mg/kg, i.p.) to evaluate its impact on thiopental sodium (TS)-induced sleep, locomotor activity, and dark-light behavior. Results demonstrated that TAN at 10 mg/kg significantly (<em>p</em> &lt; 0.05) reduced sleep onset latency and increased sleep duration, with a synergistic effect observed when combined with DZP. In locomotor activity tests, TAN dose-dependently decreased the distance traveled, while the combination with DZP further enhanced this effect. Dark-light tests revealed that TAN increased dark residence time, indicating potential anxiolytic properties. Molecular docking studies showed that TAN binds to the GABA_A receptor (α1 and β2 subunits) with a binding affinity of –6.6 kcal/mol, suggesting its interaction with GABAergic pathways. Pharmacokinetic analysis indicated high intestinal absorption and compliance with Lipinski’s rule of five, with a favorable safety profile (LD₅₀ = 5000 mg/kg). Overall, TAN enhances the sedative effects of DZP through GABA_A receptor modulation, highlighting its potential as a natural sedative agent. Further research should explore the long-term effects, bioavailability, blood–brain barrier permeability, and synergistic interactions of TAN, with comprehensive in vitro studies and clinical trials needed to validate its potential as a natural sedative.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in degree centrality and functional connectivity associated with cognitive Impairment in myotonic dystrophy type 1:A Preliminary functional MRI study","authors":"Sun Qian ,&nbsp;He Di ,&nbsp;Huang Pei ,&nbsp;Hao Zeqi ,&nbsp;Zhang Jiaxi ,&nbsp;Liu Jun ,&nbsp;Jia Xize ,&nbsp;Xue Xiaomeng ,&nbsp;Zhou Haiyan","doi":"10.1016/j.neuroscience.2025.02.040","DOIUrl":"10.1016/j.neuroscience.2025.02.040","url":null,"abstract":"<div><h3>Objectives</h3><div>The study aimed to examine alterations in voxel-based degree centrality (DC) and functional connectivity (FC), and their relationship with cognitive impairments in patients with myotonic dystrophy type 1 (DM1).</div></div><div><h3>Methods</h3><div>Eighteen DM1 patients and eighteen healthy controls participated in the study and were assessed using a comprehensive neuropsychological battery. Voxel-wise DC and FC analyses were used to assess abnormalities in functional connections among aberrant hubs. Correlational analyses were used to identify and explore the relationship between DC and FC values and cognitive performance in DM1 patients.</div></div><div><h3>Results</h3><div>DM1 patients exhibited reduced DC in the bilateral Rolandic operculum, left inferior frontal gyrus (triangular part), right angular gyrus, right median cingulate and paracingulate gyri, and right middle temporal gyrus. Conversely, increased DC was observed in the right fusiform gyrus, right hippocampus and left inferior temporal gyrus. FC analysis revealed that altered connectivity predominantly occurred among the right middle temporal gyrus, right angular gyrus and left inferior frontal gyrus (triangular part). DC value in left inferior temporal gyrus showed significant correlations with scores from the Digital Span Test-Forward (<em>r</em> = -0.556, <em>p</em> = 0.025), the Digital Span Test −Backward (<em>r</em> = -0.588, <em>p</em> = 0.017), the Auditory Verbal Learning Test (<em>r</em> = -0.586, <em>p</em> = 0.017) and the Rey-Osterrieth Complex Figure test (copying version) (<em>r</em> = 0.536, <em>p</em> = 0.032) in DM1 patients. No significant correlations were discovered between FC values and neurocognitive performances.</div></div><div><h3>Conclusion</h3><div>The study demonstrated that abnormalities in DC and FC may become potential neuroimaging biomarkers for cognitive decline in DM1 patients.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"572 ","pages":"Pages 49-55"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}