10-Hz tACS counteracts PASAT-related suppression of alpha power: A pilot study

IF 2.8 3区医学 Q2 NEUROSCIENCES

Neuroscience Pub Date : 2025-09-08 DOI:10.1016/j.neuroscience.2025.09.006

Anai Gonzalez-Ramirez , Jorge Gutierrez , Jörn Rickert , Elias Manjarrez

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Abstract

Although it is well known that the amplitude of electroencephalographic (EEG) alpha waves typically decreases during cognitive tasks, no studies have examined whether this attenuation can be modulated with external interventions. In this pilot study, we investigated whether transcranial alternating current stimulation (tACS) at a fixed frequency of 10 Hz could counteract task-related alpha suppression in 10 participants receiving experimental (verum) stimulation and 8 participants receiving sham stimulation. As expected, a mental task involving the Paced Auditory Serial Addition Test (PASAT) significantly reduced alpha power. However, after 10 min of 1 mA 10 Hz tACS, we observed a significant partial reversal of this attenuation (Group × Time: F(1,14) = 8.06, p = 0.013, η²p = 0.37), even as participants continued the task. In contrast, the sham control group showed no significant change. Consistently, PASAT behavioral accuracy improved after 10 Hz tACS (t(9) = 4.89, p = 0.0009, dz = 1.55), but not in the sham condition. In conclusion, these pilot findings demonstrate that 10 Hz tACS can counteract alpha power suppression and enhance cognitive performance during a demanding arithmetic task, warranting replication in larger and more diverse samples to confirm generalizability and clinical potential

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10hz tACS抵消pasat相关的α功率抑制：一项试点研究。

虽然众所周知，在认知任务中脑电图(EEG) α波的振幅通常会下降，但没有研究表明这种衰减是否可以通过外部干预来调节。在这项初步研究中，我们研究了固定频率为10 Hz的经颅交流电刺激（tACS）是否可以抵消10名接受实验（verum）刺激和8名接受假刺激的参与者的任务相关α抑制。正如预期的那样，一项涉及节奏性听觉序列加法测试（PASAT）的心理任务显著降低了α功率。然而, 10分钟后1马 10 赫兹tac,我们观察到的一个重要部分逆转这种衰减(集团 × 时间:F(1、14) = 8.06,p = 0.013,η2 p = 0.37),即使参与者继续任务。相比之下，假对照组无明显变化。同样，在10 Hz tACS后，PASAT行为准确性得到改善（t(9) = 4.89,p = 0.0009,dz = 1.55），但在假手术条件下没有改善。总之，这些初步研究结果表明，10 Hz的tACS可以抵消α功率抑制，并在要求苛刻的算术任务中提高认知表现，因此需要在更大、更多样化的样本中进行复制，以确认普遍性和临床潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience 医学-神经科学

CiteScore

6.20

自引率

0.00%

发文量

394

审稿时长

52 days

期刊介绍： Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.