Audiological characteristics of blast-induced hearing loss and tinnitus: unique outcomes in select cases.

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Neuroscience Pub Date : 2025-09-13 Epub Date: 2025-07-02 DOI:10.1016/j.neuroscience.2025.06.030
Anthony T Cacace, John L Woodard
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引用次数: 0

Abstract

Auditory perceptual, electroacoustic, and questionnaire-based outcomes were examined in twenty-one adults following blast overpressures. Pure-tone thresholds, monosyllabic word recognition in quiet and in noise, wide band middle ear power reflectance, distortion product otoacoustic emissions, loudness perception, tinnitus-loudness levels, and questionnaire-based assessment of self-perceived tinnitus handicap were evaluated. Audiometric data were characterized by normal pure-tone thresholds, noise-notched profiles, downward sloping, and flat audiometric losses. Within these data, two unique and novel outcomes were identified: (1) subgroups of individuals having normal pure-tone thresholds with distinctly abnormal DPOAE microstructure and (2) subgroups of individuals having reverse slope audiograms with and without concomitant high-frequency sensorineural hearing loss. Results from the Tinnitus Handicap Questionnaire were uncorrelated with any of the audiometric measures. Loudness hyperacusis was absent and cochlear synaptopathy was not convincingly observed in any of the enrollees. The assessment of individual differences was a key determinant that allowed for identification of these unique audiologic outcomes. Notably, these effects would have been missed if "averaged" results were the principal data analysis strategy used across subjects.

爆炸引起的听力损失和耳鸣的听力学特征:选择病例的独特结果。
对21名爆炸超压后的成年人进行了听觉感知、电声和问卷调查。评估了纯音阈值、安静和噪声条件下的单音节单词识别、宽带中耳功率反射、失真产物耳声发射、响度感知、耳鸣响度水平和基于问卷的自我感知耳鸣障碍评估。听力数据的特征是正常的纯音阈值、噪声缺口轮廓、向下倾斜和平坦的听力损失。在这些数据中,确定了两个独特而新颖的结果:(1)具有正常纯音阈值但DPOAE微观结构明显异常的个体亚组;(2)具有反斜度听力图并伴有或不伴有高频感音神经性听力损失的个体亚组。耳鸣障碍问卷的结果与任何听力测量都不相关。没有响度、听觉亢进,没有令人信服地观察到耳蜗突触病。个体差异的评估是确定这些独特听力学结果的关键决定因素。值得注意的是,如果“平均”结果是跨主题使用的主要数据分析策略,则这些影响将被忽略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuroscience
Neuroscience 医学-神经科学
CiteScore
6.20
自引率
0.00%
发文量
394
审稿时长
52 days
期刊介绍: Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.
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