Xiaojiao Xu , Xiaowei Xing , Yuheng Shan , Jiahua Zhao , Xiaosa Yang , Rui Liu , Yubao Ma , Jiatang Zhang
{"title":"The impact of EBV status on characteristics and outcomes of central nervous system lymphoproliferative disorder","authors":"Xiaojiao Xu , Xiaowei Xing , Yuheng Shan , Jiahua Zhao , Xiaosa Yang , Rui Liu , Yubao Ma , Jiatang Zhang","doi":"10.1016/j.neuroscience.2025.06.066","DOIUrl":null,"url":null,"abstract":"<div><div>Central nervous system lymphoproliferative disorder (CNS-LPD) is a rare disease of the central nervous system (CNS) with significant misdiagnosis and mortality, and Both EBV-positive (EBVpos) and EBV-negative (EBVneg) cases have been reported. To investigate the relationship between EBV status and the clinical characteristics and outcomes of CNS-LPD patients, we conducted a retrospective cohort study with 39 EBVpos and 41 EBVneg patients with CNS-LPD. EBVpos patients had higher rates of cerebrospinal fluid (CSF) leukocytosis, elevated protein levels, and worse functional outcomes, and no significant difference in survival was found between EBVpos and EBVneg patients. Regression analysis identified ECOG performance status ≥2 as an independent risk factor for overall survival and age ≥60, EBV-positivity, and ECOG performance status ≥2 as independent risk factors for poorer functional prognosis. These findings highlight that different management strategies should be developed for different EBV status patients.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"581 ","pages":"Pages 34-39"},"PeriodicalIF":2.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306452225007547","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Central nervous system lymphoproliferative disorder (CNS-LPD) is a rare disease of the central nervous system (CNS) with significant misdiagnosis and mortality, and Both EBV-positive (EBVpos) and EBV-negative (EBVneg) cases have been reported. To investigate the relationship between EBV status and the clinical characteristics and outcomes of CNS-LPD patients, we conducted a retrospective cohort study with 39 EBVpos and 41 EBVneg patients with CNS-LPD. EBVpos patients had higher rates of cerebrospinal fluid (CSF) leukocytosis, elevated protein levels, and worse functional outcomes, and no significant difference in survival was found between EBVpos and EBVneg patients. Regression analysis identified ECOG performance status ≥2 as an independent risk factor for overall survival and age ≥60, EBV-positivity, and ECOG performance status ≥2 as independent risk factors for poorer functional prognosis. These findings highlight that different management strategies should be developed for different EBV status patients.
期刊介绍:
Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.