Neurological Research最新文献_第5页

Intravenous lidocaine for the treatment of sepsis-associated encephalopathy: a retrospective cohort study. 静脉注射利多卡因治疗败血症相关脑病：一项回顾性队列研究

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-09 DOI: 10.1080/01616412.2024.2448634

Yu-Xuan Zhang, Lin Ma, Mailipate Yiliaikebaier, Wen Zhang, Rui-Xuan Li, Yang Wang, Zhe Chen, Gui-Ping Xu

{"title":"Intravenous lidocaine for the treatment of sepsis-associated encephalopathy: a retrospective cohort study.","authors":"Yu-Xuan Zhang, Lin Ma, Mailipate Yiliaikebaier, Wen Zhang, Rui-Xuan Li, Yang Wang, Zhe Chen, Gui-Ping Xu","doi":"10.1080/01616412.2024.2448634","DOIUrl":"10.1080/01616412.2024.2448634","url":null,"abstract":"Objective: This study aimed to evaluate the efficacy of intraoperative intravenous lidocaine administration in the management of sepsis-associated encephalopathy (SAE).Methods: This retrospective cohort analysis included 165 patients diagnosed with SAE, who were categorized into two groups: the lidocaine group (n = 55) and the control group (n = 110). The lidocaine group received an intravenous injection of lidocaine at 1.5 mg/kg following anesthesia induction, and then received a continuous infusion at 1.5 mg/kg/h until the completion of surgery. The control group did not receive lidocaine during surgery. Data collected included patient demographics, medical history, infection site, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Sequential Organ Failure Assessment (SOFA) score, Glasgow Coma Scale (GCS) score, laboratory results, anesthetic agents used, surgery duration, and length of stay in the intensive care unit (ICU). The primary outcome was the in-hospital prognosis of SAE.Results: Patients in the lidocaine group had a significantly shorter ICU stay and a significantly higher rate of favorable prognosis compared with the control group (p < 0.05). Multivariate logistic regression analysis identified age and surgery duration as risk factors for SAE prognosis, whereas intraoperative intravenous lidocaine, GCS score, and intravenous dexmedetomidine emerged as protective factors.Conclusion: Intraoperative intravenous administration of lidocaine significantly enhanced the prognosis of SAE patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"115-121"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1080/01616412.2025.2456355

引用次数: 0

Endovascular management of carotid blowout syndrome.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-26 DOI: 10.1080/01616412.2024.2448635

Omer F Nas, Sedat G Kandemirli, Baris Korkmaz, Mehmet F Inecikli, Muhammed F Oztepe, Cem Bilgin, Bahattin Hakyemez

{"title":"Endovascular management of carotid blowout syndrome.","authors":"Omer F Nas, Sedat G Kandemirli, Baris Korkmaz, Mehmet F Inecikli, Muhammed F Oztepe, Cem Bilgin, Bahattin Hakyemez","doi":"10.1080/01616412.2024.2448635","DOIUrl":"10.1080/01616412.2024.2448635","url":null,"abstract":"Objectives: To evaluate success, complications and efficacy for endovascular management for carotid blowout syndrome.Methods: Images were evaluated for contrast extravasation, vessel wall irregularity, pseudoaneurysm/aneurysm formation. Hemostatic results in the immediate postprocedural period and procedure related infarcts were assessed.Results: Total of 20 lesions in 21 patients were detected on digital subtraction angiography (DSA). In a case of esthesioneuroblastoma with active bleeding, DSA failed to show vascular abnormality. There was active contrast extravasation in 7 cases. Treatment modalities included covered stent placement (n = 3), pseudoaneurysm/aneurysm embolization (n = 4), parent artery occlusion (n = 13) and PVA injection (n = 1) in the immediate postoperative period was achieved in all except one case. During the post-procedural period, 6 patients (28.6%) suffered from cerebral ischemia. Rebleeding episodes were encountered in 10 cases (47.6%) after a mean duration of 35 days which responded to tamponade in 4 cases. Diagnostic DSA was performed in 5 of the cases, which failed to identify bleeding source in 2 and remaining 3 cases were treated by endovascular means. A case with massive hemorrhage 1-hour after endovascular treatment died before any intervention could be performed.Conclusion: Endovascular treatment can achieve immediate hemostasis to prevent otherwise a highly morbid and mortal complication. However, rebleeding rates are high and cerebral ischemia with or without neurologic deficit occur in a non-negligible percentage of patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"122-128"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of a single dose of Mk-801 use on adult brain tissue after an experimental head trauma model applied in immature rats.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-26 DOI: 10.1080/01616412.2024.2448633

Ayşe Çiğel, Oya Sayın, Seren Gülşen Gürgen, Ataç Sönmez

{"title":"The effect of a single dose of Mk-801 use on adult brain tissue after an experimental head trauma model applied in immature rats.","authors":"Ayşe Çiğel, Oya Sayın, Seren Gülşen Gürgen, Ataç Sönmez","doi":"10.1080/01616412.2024.2448633","DOIUrl":"10.1080/01616412.2024.2448633","url":null,"abstract":"Objective: Within the scope of this research, the long-term effects of experimental blunt head trauma on immature rats and MK-801 administered acutely after trauma on the brain tissue will be examined. In addition, the impact of trauma and MK-801 on Nestin and CD133, which are essential stem cells, will be evaluated by immunohistochemical and ELISA methods.Methods: In this study, the contusion trauma model was used. Sprague Dawley rats 30 7-day-old were divided into three groups: Group 1 (n = 10) control group, Group 2 (n = 10) trauma Group (head trauma applied), and Group 3 (n = 10) MK-801 + trauma Group. In the third group, immediately after head trauma, MK-801 (Sigma M107) dissolved in physiological saline was administered as a single dose of 1 mg/kg ip.Results: The concentration of nestin was significantly higher in the control group compared to both the trauma and trauma+drug groups (p < 0.001). CD133 was statistically significantly higher in the control group compared to the other two groups (p = 0.002). It was determined that the differences in Nestin CA1 and DG measurements resulted from the trauma and control and trauma and trauma+drug groups, and the differences in CD133 CA1 and DG measurements resulted from the trauma and control group.Conclusion: The positive effect of MK-801 on neuroprotective and neuronal proliferation was elaborated. Administration of MK-801 significantly induced nestin and CD133 concentrations in the injured tissue.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"105-114"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic associations between immune-related plasma proteins and neurodegenerative diseases. 免疫相关血浆蛋白与神经退行性疾病之间的遗传关联。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-01 DOI: 10.1080/01616412.2024.2448745

Zihao Wang, Xiaobei Wang, Peishan Li, Huan Xia, Xinling Yang

{"title":"Genetic associations between immune-related plasma proteins and neurodegenerative diseases.","authors":"Zihao Wang, Xiaobei Wang, Peishan Li, Huan Xia, Xinling Yang","doi":"10.1080/01616412.2024.2448745","DOIUrl":"10.1080/01616412.2024.2448745","url":null,"abstract":"Background: Immune dysregulation is commonly associated with neurodegenerative diseases (NDs), yet the underlying causes and mechanisms still require further investigation.Objective: This study investigates the correlation between immune-related plasma proteins and the risk of NDs by integrating genome-wide association study (GWAS) data for Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) with plasma proteome analysis.Methods: By analyzing GWAS data for 4907 immune-related plasma proteins, this research evaluates the direct impact of plasma proteins on the risk of four NDs: AD, PD, ALS, and MS. Additionally, the study conducts an analysis of protein expression levels using single-cell RNA sequencing data.Results: We have identified plasma proteins that are closely associated with the risk of NDs. Using stringent criteria, we identified 88 proteins associated with AD, 115 with PD, 100 with ALS, and 87 with MS. Additionally, single-cell sequencing analyzed the protein expression and its distribution within different cell types in the brain.Conclusions: Our research has demonstrated that plasma proteins may contribute to the risk of NDs, and it has also provided concrete evidence linking genetic susceptibility for these diseases to immune mechanisms. Furthermore, we found that specific proteins influence genetic variations linked to NDs risk via plasma-mediated regulation, emphasizing the importance of interactions between the brain and circulatory system.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"129-138"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of eight weeks of aerobic training with vitamin C on some apoptotic markers in the hippocampus tissue of rats with Alzheimer's disease; an experimental study. 8周维生素C有氧训练对阿尔茨海默病大鼠海马组织部分凋亡标志物的影响一项实验性研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-04 DOI: 10.1080/01616412.2024.2448624

Azadeh Farzi, Amin Teymoor Davani, Asiye Seyed, Omidreza Salehi, Zahra Mosallanezhad

{"title":"The effect of eight weeks of aerobic training with vitamin C on some apoptotic markers in the hippocampus tissue of rats with Alzheimer's disease; an experimental study.","authors":"Azadeh Farzi, Amin Teymoor Davani, Asiye Seyed, Omidreza Salehi, Zahra Mosallanezhad","doi":"10.1080/01616412.2024.2448624","DOIUrl":"10.1080/01616412.2024.2448624","url":null,"abstract":"Objectives: The aim of this study was to investigate the effect of eight weeks of aerobic training (AT) and vitamin C supplementation (VC) on apoptotic markers in hippocampus tissue of AD rats treated with trimethyltin (TMT).Materials and methods: In this experimental study, 32 Sprague- Dawley rats (mean age: 14-18 months and mean weight 270-320 g) were treated with (10 mg/kg) TMT and divided into 4 groups including: 1) ADcontrol, 2) VC, 3) AT and 4) AT+VC groups. In order to investigate the effects of AD induction on research variables, 8 healthy rats selected as healthy control group (HC). Groups 3 and 4 trained for eight weeks, three sessions per week and each session lasted 15-48 minutes with an intensity of 10-24 m/min. Groups 2 and 4 received 4 mg/kg VC orally. One-way ANOVA with Tukey's post- hoc tests were used for statistical analysis of data (p ≤ 0.05).Results: The gene expression levels of Caspase 3, FasL, Cyt-C and AP-1 in the AT, VC and AT+VC groups were significantly lower than TMT group (p ≤ 0.05); Caspase 3, FasL and Cyt-C levels were significantly lower in the AT+VC group compare to VC and ET groups (p ≤ 0.05). CytC levels in AT group were significantly lower than VC group (p = 0.002). Also, AP-1 levels in AT+VC group were significantly lower than AT group (p = 0.01).Conclusions: It seems that AT and VC, both alone and interactively, can probably induce their anti-apoptotic effects in the hippocampus tissue of rats with AD via a common signaling pathway.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"77-86"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of D-dimer/fibrinogen ratio and combination of D-dimer and fibrinogen with prognosis of stroke and stroke subtypes. d -二聚体/纤维蛋白原比值及d -二聚体与纤维蛋白原联合与脑卒中及脑卒中亚型预后的关系

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2024-12-31 DOI: 10.1080/01616412.2024.2448630

Yun Zhai, Mengmeng Huo, Yue Liu, Hongwei Sun, Yanyan Sun, Fang Li, Hongwei Sun, Ying Tang

{"title":"Association of D-dimer/fibrinogen ratio and combination of D-dimer and fibrinogen with prognosis of stroke and stroke subtypes.","authors":"Yun Zhai, Mengmeng Huo, Yue Liu, Hongwei Sun, Yanyan Sun, Fang Li, Hongwei Sun, Ying Tang","doi":"10.1080/01616412.2024.2448630","DOIUrl":"10.1080/01616412.2024.2448630","url":null,"abstract":"Objective: Here, we aim to investigate whether D-dimer (DD)/fibrinogen (FIB) ratio or combination of DD and FIB contribute to the prognosis of stroke and stroke subtypes.Methods: 1413 patients with acute ischemic stroke (AIS) were recruited. We measured DD and FIB levels on admission and followed up with patients at discharge and 90-day following discharge. We analyzed the association between DD/FIB ratio and poor function outcome of AIS and different AIS subtypes. Similarly, logistic regression model was used to estimate the combined effect of DD level and FIB level on the poor outcomes of stroke and stroke subtypes.Results: The patients with DD+FIB+ or high DD/FIB ratio tended to have the high risk of severe neurological deficits at both discharge and 90-day following discharge. In the subgroup analysis, high DD/FIB ratio was significantly associated with the poor function outcome in cardioembolism (CE) and large-artery atherosclerosis (LAA) subtypes. DD+FIB+ was strongly associated with the poor function outcome in CE subtype at discharge and 90-day.Conclusion: DD/FIB ratio and combination of DD and FIB may have more significant prognostic value of stroke and stroke subtypes than either index of DD or FIB alone in AIS patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"96-104"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global trends and hot spots in cerebral venous sinus thrombosis research over the past 50 years: a bibliometric analysis. 过去 50 年脑静脉窦血栓研究的全球趋势和热点：文献计量分析。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI: 10.1080/01616412.2024.2430999

Fatma Yardibi, Seden Demirci

{"title":"Global trends and hot spots in cerebral venous sinus thrombosis research over the past 50 years: a bibliometric analysis.","authors":"Fatma Yardibi, Seden Demirci","doi":"10.1080/01616412.2024.2430999","DOIUrl":"10.1080/01616412.2024.2430999","url":null,"abstract":"Background: Cerebral venous sinus thrombosis (CVST) is an uncommon form of cerebrovascular disease. Although our understanding of CVST has improved significantly over the past decades, there has been no bibliometric analysis of CVST until now. We aimed to examine and visualize the hotspots and trends of the research related to CVST using a bibliometric analysis based on Citespace and provide new insights for scholars in their future researches in this area.Methods: The literature on CVST was collected from the Web of Science Core Collection database. Bibliometric analysis was performed using CiteSpace (6.2.R3) Advanced software.Results: A total of 2396 articles were included in the analysis. Publications regarding CVST have increased over time. U.S.A. contributed the most articles. Ferro JM had the highest number of published papers. Stroke was the journal with the most publications and the most commonly cited journal. Nine out of the top 10 cited journals belong to Q1. The risk factors for CVST, emerging and current treatment of CVST, and CVST related to COVID-19 and COVID-19 vaccines are the major potential research hot spots and trends.Conclusions: CVST is a rapidly expanding research area and has received increasing attention by the researchers. Our study can provide researchers valuable information on the current status and trends in this area and guide for future studies.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"23-34"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin ameliorates aluminum oxide nanoparticle-induced memory deficit by regulating the hippocampal p38 signaling pathway in mice. 姜黄素通过调节小鼠海马p38信号通路改善氧化铝纳米粒子诱导的记忆缺陷

IF 1.7 4区医学

Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1080/01616412.2024.2430998

Roksana Soukhaklari, Fatema Pirsalami, Leila Moezi, Maryam Moosavi

{"title":"Curcumin ameliorates aluminum oxide nanoparticle-induced memory deficit by regulating the hippocampal p38 signaling pathway in mice.","authors":"Roksana Soukhaklari, Fatema Pirsalami, Leila Moezi, Maryam Moosavi","doi":"10.1080/01616412.2024.2430998","DOIUrl":"10.1080/01616412.2024.2430998","url":null,"abstract":"Objectives: Exposure to aluminum (Al) has been shown to be strongly associated with the pathogenesis of Alzheimer's disease (AD). Recent evidence indicates that the toxicity of Al nanoparticle (Al-NP) is far greater than Al itself due to its particle size. Epidemiological studies suggest that curcumin lower the prevalence of AD. MAPKs (ERK, p38 and JNK) were suggested to be involved in AD pathology and memory impairment. The present study aimed to evaluate if curcumin has the ability to protect against behavioral deficits induced by subcutaneously administered Al-NP in mice. Furthermore, the levels of phosphorylated and total hippocampal MAPKs were assessed using western blottechnique.Methods: Al-NP (10 mg/kg/s.c.) was administered to adult male NMRI mice for 10 days with or without curcumin in doses of 2.5 or 25 mg/kg/oral gavage). Memory was assessed using passive avoidance apparatus and anxiety-like behavior was evaluated using elevated plus maze. Following the behavioral tasks, western blot analysis was performed on the hippocampal tissues to detect the levels of phosphorylated and total MAPKs.Results: The results revealed that Al-NP deteriorated memory with no significant effect on anxiety-like behaviors. Additionally, it activated hippocampal p38 signaling pathway with no effect on ERK and JNK. Curcumin treatment at the dose of 25 mg/kg restored memory and p38 activation.Discussion: This study suggests that subcutaneous Al-NP administration impairs memory and hippocampal p38 signaling with no effect on ERK and JNK. Co-administration of curcumin restored Al-NP induced memory impairment and hippocampal p38 phosphorylation.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"15-22"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemogram and inflammatory indices in pain-free periods in migraine patients without aura. 无先兆偏头痛患者无痛期的血象和炎症指标。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1080/01616412.2024.2438616

Hatice Ferhan Kömürcü, Ceren Erkalaycı, Eren Gozke

{"title":"Hemogram and inflammatory indices in pain-free periods in migraine patients without aura.","authors":"Hatice Ferhan Kömürcü, Ceren Erkalaycı, Eren Gozke","doi":"10.1080/01616412.2024.2438616","DOIUrl":"10.1080/01616412.2024.2438616","url":null,"abstract":"Objectives: Since neurogenic inflammation and hemoconcentration have a prominent role in the pathophysiology of migraine, evaluation of hemogram parameters and indices showing inflammation can yield important information. In this study, we have investigated blood cell counts and ratios, systemic inflammation index (SII), systemic inflammation response index (SIRI) and red cell index (RCI) in the painless periods between pain attacks in patients with episodic migraine without aura.Methods: Hemogram data of both 309 patients diagnosed with migraine without aura related to pain-free periods and 199 healthy individuals were retrospectively retrieved from hospital records. Data related to erythrocyte, leukocyte, lymphocyte, platelet, monocyte, eosinophil counts; hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio (MLR), and neutrophil/monocyte ratio, SII, SIRI and RCI values were scanned to reveal intergroup differences in terms of these parameters.Results: A comparison of laboratory parameters revealed that certain indices differed significantly between the migraine and control groups. MLR (p = 0.005) and RDW (p < 0.001) values were significantly lower, while platelet (p = 0.016), MPV (p < 0.001) and hematocrit (p = 0.014) were significantly higher in the migraine patient group compared to the control group. There was no significant difference between the two groups regarding other parameters.Discussion: Higher hematocrit, platelet, mean platelet volume and lower monocyte/lymphocyte ratio values in this study support that hemoconcentration and chronic inflammation persist even in the absence of pain attacks in migraine patients without aura.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"44-50"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0