Neurological Research最新文献_第5页

Migraine and ergot use increase plasma pentraxin 3 levels: an Egyptian study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1080/01616412.2025.2456708

Ebtesam Mohamed Fahmy, Mona Af Nada, Nouran Alaa Abd El Hamid, Sahar Abd Elatty Sharaf, Wessam Osama, Haidy Elshebawy

{"title":"Migraine and ergot use increase plasma pentraxin 3 levels: an Egyptian study.","authors":"Ebtesam Mohamed Fahmy, Mona Af Nada, Nouran Alaa Abd El Hamid, Sahar Abd Elatty Sharaf, Wessam Osama, Haidy Elshebawy","doi":"10.1080/01616412.2025.2456708","DOIUrl":"10.1080/01616412.2025.2456708","url":null,"abstract":"Background: Endothelial dysfunction and inflammation are linked to migraine, which may contribute to atherogenesis and increase the risk of ischemia. In migraineurs, preclinical vascular involvement manifested as compromised structural characteristics of vessel wall has not received enough attention or evaluation.Objectives: To measure plasma pentraxin 3 as an indicator of endothelial dysfunction in migraine in comparison to controls and to examine its correlation with clinical characteristics, headache severity, and brain magnetic resonance imaging findings.Subjects and methods: This study was conducted on 40 migraineurs and 40 healthy matched control subjects. The severity and intensity of headaches were quantified using the Headache Impact Test and the translated Arabic version of Migraine Disability assessment questionnaires. Both patients and controls underwent routine laboratory assessment, brain MR imaging, and measurement of plasma pentraxin 3 level.Results: Patients with migraine had a significantly higher mean plasma pentraxin 3 when compared to controls. Patients with chronic migraine and those taking ergots also had significantly higher plasma pentraxin 3 levels. Additionally, there were statistically significant positive correlation between frequency of headaches and duration of the disease with plasma pentraxin 3 level. For diagnosing endothelial dysfunction in migraine patients, the sensitivity and specificity of pentraxin 3 levels were 85% and 95%, respectively, with cut-off value of 3.100 ng/ml.Conclusion: Pentraxin 3 levels could be used as a chemical biomarker for endothelial dysfunction in migraines with high sensitivity and specificity. Higher plasma levels of pentraxin 3 in patients receiving ergots may influence the selection of treatment for migraine patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"155-162"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of cognitive fatigue on balance in individuals with multiple sclerosis without cognitive impairment.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/01616412.2025.2462733

Kübra Turan, Ayla Fil Balkan, Elçin Özçelik Eroğlu, Songül Aksoy, Nazire Pınar Acar Özen, Aslı Tuncer, Yeliz Salcı

{"title":"Impact of cognitive fatigue on balance in individuals with multiple sclerosis without cognitive impairment.","authors":"Kübra Turan, Ayla Fil Balkan, Elçin Özçelik Eroğlu, Songül Aksoy, Nazire Pınar Acar Özen, Aslı Tuncer, Yeliz Salcı","doi":"10.1080/01616412.2025.2462733","DOIUrl":"10.1080/01616412.2025.2462733","url":null,"abstract":"Purpose: This study aims to examine the impact of cognitive fatigue on balance among individuals with multiple sclerosis (MS) without cognitive impairment.Method: A total 50 individuals with MS aged 20-50 years, without cognitive impairment and with an Expanded Disability Status Scale (EDSS) score of 0-4, participated in the study. Participants were randomly assigned to either a control group (CG) or a study group (SG). The CG rested for 30 minutes, while the SG engaged in cognitive activities lasting 30-45 minutes to induce cognitive fatigue. Cognitive fatigue was assessed using the Visual Analog Scale (VAS) before and after the tasks. Balance was evaluated using clinical tests: the Functional Reach Test (FRT) and the Single Leg Stance Test (SLST), as well as laboratory assessments including the Modified Clinical Test of Sensory Integration and Balance (mCTSIB) and Limits of Stability (LOS) with static posturography.Results: Within-group analyses showed a significant increase in cognitive fatigue on the VAS in the SG (p < 0.001). In the mCTSIB, the SG showed significant changes in firm/eyes open, foam/eyes open, and composite scores, while between-group differences were observed only in firm/eyes open and foam/eyes open conditions (p < 0.005). No significant differences were found between groups in LOS, FRT, or SLST outcomes (p > 0.05).Conclusion: In individuals with MS, the impact observed only in the eyes-open static balance condition suggests that dynamic balance and eyes-closed static balance parameters rely more on automatic mechanisms compared to the eyes-open condition and are not influenced by cognitive fatigue.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"178-187"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between smoking and clinical outcome in ischemic stroke patients undergoing reperfusion therapy. 再灌注治疗缺血性脑卒中患者吸烟与临床转归的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-03 DOI: 10.1080/01616412.2024.2448628

Hatice Ferhan Kömürcü, Nisa Sever, Nazlı Seda Gökdereli, Ozan Keske, Eren Gözke

{"title":"The relationship between smoking and clinical outcome in ischemic stroke patients undergoing reperfusion therapy.","authors":"Hatice Ferhan Kömürcü, Nisa Sever, Nazlı Seda Gökdereli, Ozan Keske, Eren Gözke","doi":"10.1080/01616412.2024.2448628","DOIUrl":"10.1080/01616412.2024.2448628","url":null,"abstract":"Background: It has been suggested that smokers have higher recanalization rate, lower risk of cerebral hemorrhage and better prognosis than non-smokers (smoking paradox) after reperfusion therapy in patients with acute ischemic stroke (IS). This study aimed to assess the effects of smoking on recanalization, intracranial hemorrhage, and clinical outcomes in patients with acute IS following reperfusion therapy.Methods: Patients were categorized into smokers and non-smokers, with data collected on types of reperfusion therapy, demographics, medication use, comorbidities, stroke etiology, mRS and NIHSS scores, TICI and ECASS classifications.Results: The study involved 662 patients (344 men and 318 women) treated with rtPA and/or thrombectomy. Smoking was more prevalent among men. Smokers were typically younger, had lower hypertension rates, lower systolic blood pressure, and higher triglyceride and HDL levels compared to non-smokers. They exhibited a higher incidence of cardioembolic strokes and strokes with known causes but a lower incidence of small vessel occlusion. Smokers had higher GCS scores and more posterior cerebral circulation strokes upon hospital admission. NIHSS scores were lower at admission and on the third day, and poor outcome rates (mRS) were lower at both hospital admission and three months post-stroke for smokers. However, smokers who developed hemorrhagic complications had a higher frequency of parenchymal hematoma according to ECASS classification.Conclusions: Our findings did not support claims that smoking increases recanalization rates, reduces cerebral hemorrhage risk, or improves clinical outcomes. Further prospective studies with larger samples are needed to explore smoking's impact on stroke outcomes.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"87-95"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting sinking skin flap syndrome: a series of case reports and literature review on cranioplasty with PEEK implants. 重述皮瓣下沉综合征：PEEK植入颅骨成形术的一系列病例报告和文献综述。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-19 DOI: 10.1080/01616412.2024.2448632

Junlin Kang, Xiaofeng Xu, Shilai Tian, Gang Yang

引用次数: 0

Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats. 在雄性大鼠中，kisspeptin拮抗剂p234（而非kisspeptin-10）可降低癫痫样活动的强度和慢脑电图。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1080/01616412.2025.2456293

Ömer Faruk Kalkan, Zafer Şahin, Osman Aktaş, Abdulhamit Yildirim, Selcen Aydin Abidin, Ali Faruk Özyaşar, İbrahim Uzun, İsmail Abidin

{"title":"Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.","authors":"Ömer Faruk Kalkan, Zafer Şahin, Osman Aktaş, Abdulhamit Yildirim, Selcen Aydin Abidin, Ali Faruk Özyaşar, İbrahim Uzun, İsmail Abidin","doi":"10.1080/01616412.2025.2456293","DOIUrl":"10.1080/01616412.2025.2456293","url":null,"abstract":"Introduction: We aimed to investigate the effects of central kisspeptin-10 and p234 administration on basal brain activity and epilepsy-like conditions induced by 4-aminopyridine (4-AP), as well as their roles in the electrocorticogram (ECoG) power spectrum and EEG waves.Methods: Thirty-five male Wistar rats were divided into five groups: sham,4-AP (2.5 mg/kg i.p.), kisspeptin-10 post-treatment (200 pmoli.c.v.), p234 post-treatment (1 nmol i.c.v.), and p234 pre-treatment (1 nmol i.c.v.). We performed 70 minutes of recordings (10 min baseline) for all groups under ketamine/xylazine (90/10 mg/kg) anesthesia. In the post-treatment groups, kisspeptin-10 or p234 injections were administered 20 minutes after epilepsy induction. In the pre-treatment group, p234 was injected after baseline recordings. Following a 20-minute pre-treatment period, 4-AP was administered.Results: 4-AP alone induced epileptiform activity in all animals, reaching apeak after 30 minutes. Neither kisspeptin-10 nor p234 post-treatment affected 4-AP-induced epileptiform activity (p > 0.05). However, p234 pre-treatment reduced epileptiform activity (p < 0.05). Additionally, kisspeptin-10 did not alter the spectral analysis of the EEG bands or the power of the ECoG (p > 0.05). In contrast, p234 reduced the power of the ECoG and the slow bands (delta and theta) (p < 0.05).Conclusion: We conclude that p234 pre-treatment has an inhibitory effect on neuronal excitability and epileptiform activity in the neocortex.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"139-146"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous lidocaine for the treatment of sepsis-associated encephalopathy: a retrospective cohort study. 静脉注射利多卡因治疗败血症相关脑病：一项回顾性队列研究

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-09 DOI: 10.1080/01616412.2024.2448634

Yu-Xuan Zhang, Lin Ma, Mailipate Yiliaikebaier, Wen Zhang, Rui-Xuan Li, Yang Wang, Zhe Chen, Gui-Ping Xu

{"title":"Intravenous lidocaine for the treatment of sepsis-associated encephalopathy: a retrospective cohort study.","authors":"Yu-Xuan Zhang, Lin Ma, Mailipate Yiliaikebaier, Wen Zhang, Rui-Xuan Li, Yang Wang, Zhe Chen, Gui-Ping Xu","doi":"10.1080/01616412.2024.2448634","DOIUrl":"10.1080/01616412.2024.2448634","url":null,"abstract":"Objective: This study aimed to evaluate the efficacy of intraoperative intravenous lidocaine administration in the management of sepsis-associated encephalopathy (SAE).Methods: This retrospective cohort analysis included 165 patients diagnosed with SAE, who were categorized into two groups: the lidocaine group (n = 55) and the control group (n = 110). The lidocaine group received an intravenous injection of lidocaine at 1.5 mg/kg following anesthesia induction, and then received a continuous infusion at 1.5 mg/kg/h until the completion of surgery. The control group did not receive lidocaine during surgery. Data collected included patient demographics, medical history, infection site, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Sequential Organ Failure Assessment (SOFA) score, Glasgow Coma Scale (GCS) score, laboratory results, anesthetic agents used, surgery duration, and length of stay in the intensive care unit (ICU). The primary outcome was the in-hospital prognosis of SAE.Results: Patients in the lidocaine group had a significantly shorter ICU stay and a significantly higher rate of favorable prognosis compared with the control group (p < 0.05). Multivariate logistic regression analysis identified age and surgery duration as risk factors for SAE prognosis, whereas intraoperative intravenous lidocaine, GCS score, and intravenous dexmedetomidine emerged as protective factors.Conclusion: Intraoperative intravenous administration of lidocaine significantly enhanced the prognosis of SAE patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"115-121"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1080/01616412.2025.2456355

引用次数: 0

Endovascular management of carotid blowout syndrome.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-26 DOI: 10.1080/01616412.2024.2448635

Omer F Nas, Sedat G Kandemirli, Baris Korkmaz, Mehmet F Inecikli, Muhammed F Oztepe, Cem Bilgin, Bahattin Hakyemez

{"title":"Endovascular management of carotid blowout syndrome.","authors":"Omer F Nas, Sedat G Kandemirli, Baris Korkmaz, Mehmet F Inecikli, Muhammed F Oztepe, Cem Bilgin, Bahattin Hakyemez","doi":"10.1080/01616412.2024.2448635","DOIUrl":"10.1080/01616412.2024.2448635","url":null,"abstract":"Objectives: To evaluate success, complications and efficacy for endovascular management for carotid blowout syndrome.Methods: Images were evaluated for contrast extravasation, vessel wall irregularity, pseudoaneurysm/aneurysm formation. Hemostatic results in the immediate postprocedural period and procedure related infarcts were assessed.Results: Total of 20 lesions in 21 patients were detected on digital subtraction angiography (DSA). In a case of esthesioneuroblastoma with active bleeding, DSA failed to show vascular abnormality. There was active contrast extravasation in 7 cases. Treatment modalities included covered stent placement (n = 3), pseudoaneurysm/aneurysm embolization (n = 4), parent artery occlusion (n = 13) and PVA injection (n = 1) in the immediate postoperative period was achieved in all except one case. During the post-procedural period, 6 patients (28.6%) suffered from cerebral ischemia. Rebleeding episodes were encountered in 10 cases (47.6%) after a mean duration of 35 days which responded to tamponade in 4 cases. Diagnostic DSA was performed in 5 of the cases, which failed to identify bleeding source in 2 and remaining 3 cases were treated by endovascular means. A case with massive hemorrhage 1-hour after endovascular treatment died before any intervention could be performed.Conclusion: Endovascular treatment can achieve immediate hemostasis to prevent otherwise a highly morbid and mortal complication. However, rebleeding rates are high and cerebral ischemia with or without neurologic deficit occur in a non-negligible percentage of patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"122-128"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of a single dose of Mk-801 use on adult brain tissue after an experimental head trauma model applied in immature rats.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-26 DOI: 10.1080/01616412.2024.2448633

Ayşe Çiğel, Oya Sayın, Seren Gülşen Gürgen, Ataç Sönmez

{"title":"The effect of a single dose of Mk-801 use on adult brain tissue after an experimental head trauma model applied in immature rats.","authors":"Ayşe Çiğel, Oya Sayın, Seren Gülşen Gürgen, Ataç Sönmez","doi":"10.1080/01616412.2024.2448633","DOIUrl":"10.1080/01616412.2024.2448633","url":null,"abstract":"Objective: Within the scope of this research, the long-term effects of experimental blunt head trauma on immature rats and MK-801 administered acutely after trauma on the brain tissue will be examined. In addition, the impact of trauma and MK-801 on Nestin and CD133, which are essential stem cells, will be evaluated by immunohistochemical and ELISA methods.Methods: In this study, the contusion trauma model was used. Sprague Dawley rats 30 7-day-old were divided into three groups: Group 1 (n = 10) control group, Group 2 (n = 10) trauma Group (head trauma applied), and Group 3 (n = 10) MK-801 + trauma Group. In the third group, immediately after head trauma, MK-801 (Sigma M107) dissolved in physiological saline was administered as a single dose of 1 mg/kg ip.Results: The concentration of nestin was significantly higher in the control group compared to both the trauma and trauma+drug groups (p < 0.001). CD133 was statistically significantly higher in the control group compared to the other two groups (p = 0.002). It was determined that the differences in Nestin CA1 and DG measurements resulted from the trauma and control and trauma and trauma+drug groups, and the differences in CD133 CA1 and DG measurements resulted from the trauma and control group.Conclusion: The positive effect of MK-801 on neuroprotective and neuronal proliferation was elaborated. Administration of MK-801 significantly induced nestin and CD133 concentrations in the injured tissue.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"105-114"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic associations between immune-related plasma proteins and neurodegenerative diseases. 免疫相关血浆蛋白与神经退行性疾病之间的遗传关联。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-01 DOI: 10.1080/01616412.2024.2448745

Zihao Wang, Xiaobei Wang, Peishan Li, Huan Xia, Xinling Yang

{"title":"Genetic associations between immune-related plasma proteins and neurodegenerative diseases.","authors":"Zihao Wang, Xiaobei Wang, Peishan Li, Huan Xia, Xinling Yang","doi":"10.1080/01616412.2024.2448745","DOIUrl":"10.1080/01616412.2024.2448745","url":null,"abstract":"Background: Immune dysregulation is commonly associated with neurodegenerative diseases (NDs), yet the underlying causes and mechanisms still require further investigation.Objective: This study investigates the correlation between immune-related plasma proteins and the risk of NDs by integrating genome-wide association study (GWAS) data for Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) with plasma proteome analysis.Methods: By analyzing GWAS data for 4907 immune-related plasma proteins, this research evaluates the direct impact of plasma proteins on the risk of four NDs: AD, PD, ALS, and MS. Additionally, the study conducts an analysis of protein expression levels using single-cell RNA sequencing data.Results: We have identified plasma proteins that are closely associated with the risk of NDs. Using stringent criteria, we identified 88 proteins associated with AD, 115 with PD, 100 with ALS, and 87 with MS. Additionally, single-cell sequencing analyzed the protein expression and its distribution within different cell types in the brain.Conclusions: Our research has demonstrated that plasma proteins may contribute to the risk of NDs, and it has also provided concrete evidence linking genetic susceptibility for these diseases to immune mechanisms. Furthermore, we found that specific proteins influence genetic variations linked to NDs risk via plasma-mediated regulation, emphasizing the importance of interactions between the brain and circulatory system.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"129-138"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0