Neurological Research最新文献

{"title":"Integrated single-cell and spatial transcriptomics uncover the prognostic, epigenetic, and immunological roles of FANCC in low-grade glioma.","authors":"Zongye Zhang, Zhi Sha, Han Liu, Yusheng Chen, Zhendong Liu, Xingbo Cheng, Sujie Gu, Yanzheng Gao","doi":"10.1080/01616412.2025.2556255","DOIUrl":"https://doi.org/10.1080/01616412.2025.2556255","url":null,"abstract":"<p><strong>Background: </strong>Immunotherapy holds significant yet underexplored potential for low-grade glioma (LGG) treatment. We therefore interrogated the role of Fanconi Anemia Complementation Group C (FANCC) as a novel immune checkpoint regulator given its spatial correlation with tumor microenvironments and clinical associations with immunosuppressive markers.</p><p><strong>Objectives: </strong>FANCC is implicated in various tumor progressions; its role in LGG remains unexplored. This study comprehensively investigates FANCC's clinical significance, prognostic value, and molecular mechanisms driving LGG malignancy to identify novel therapeutic targets.</p><p><strong>Results: </strong>FANCC overexpression in malignant single-cell subclusters correlated with advanced grade/recurrence. It independently predicted poor prognosis (KM log-rank <i>p</i> < 0.001; multivariate Cox HR = 2.1, <i>p</i> < 0.001). Spatial mapping revealed colocalization with immunosuppressive niches, supported by strong correlations with CD4+ T cells (<i>r</i> = 0.68) and M2 macrophages (<i>r</i> = 0.72), while inversely linking to M1 markers (<i>r</i> = -0.42). Immune checkpoints (PD-1/CTLA-4) showed significant co-expression (<i>r</i> > 0.4). GSEA implicated FANCC in DNA replication and base excision repair (FDR < 0.05), suggesting genomic instability drives progression.</p><p><strong>Conclusion: </strong>As the first-reported oncogenic driver in LGG, FANCC synergistically fuels progression via immune microenvironment reprogramming and DNA repair dysregulation, establishing its potential as a diagnostic/prognostic biomarker and therapeutic target.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of high-frequency repetitive transcranial magnetic stimulation coupled with rehabilitation in patients with spinal cord injury: a systematic review.","authors":"Rudraksh Banga, Kavin Devani, Kanwal Preet Kochhar, Suman Jain","doi":"10.1080/01616412.2025.2558860","DOIUrl":"https://doi.org/10.1080/01616412.2025.2558860","url":null,"abstract":"<p><strong>Background: </strong>Spinal Cord Injury (SCI) leads to partial or complete sensorimotor loss because of the spinal lesions caused either by trauma or any pathological conditions. Rehabilitation, one of the therapeutic methods, is considered to be a significant part of therapy supporting patients with spinal cord injury. Newer methods are being incorporated, such as repetitive Transcranial Magnetic Stimulation (rTMS), a Non-Invasive Brain Stimulation (NIBS) technique to induce changes in the residual neuronal pathways, facilitating cortical excitability and neuroplasticity.</p><p><strong>Study design: </strong>PRISMA-guided systematic review.</p><p><strong>Objective: </strong>To comprehend the therapeutic efficacy of rTMS combined with rehabilitation in SCI patients by evaluating the results reported in previous studies.</p><p><strong>Methodology: </strong>An online electronic search was executed on the scientific databases, PUBMED, COCHRANE LIBRARY, and SCOPUS using the keywords: 'Spinal Cord Injury (SCI),' 'repetitive Transcranial Magnetic Stimulation (rTMS),' and 'rehabilitation' and articles published in the English language between the years 2010 to 2024 were screened and extracted based on the eligibility criteria according to PICOS framework.</p><p><strong>Results: </strong>Four full-text articles were selected and analysed. Following HF-rTMS and neuro-rehabilitation, significant upper and lower extremity functional gains marked by UEMS & LEMS and a reduction in lower limb spasticity were reported by MAS scores in active SCI groups.</p><p><strong>Conclusion: </strong>To modulate corticospinal tract fiber excitability and reduce spasticity in patients with SCI, HF-rTMS shows promising therapeutic effects if combined with a rehabilitation program.</p><p><strong>Prospero id: </strong>CRD420251028333.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation the antioxidant effects of scaffold containing curcumin nanoparticles in unilateral spinal cord injury model in the male rats.","authors":"Babak Ebrahimi, Mohsen Chamanara, Gholamreza Hassanzadeh, Seyed Amir Mousavian, Laya Ghahari, Mohsen Ebrahimi","doi":"10.1080/01616412.2025.2553150","DOIUrl":"https://doi.org/10.1080/01616412.2025.2553150","url":null,"abstract":"<p><strong>Background: </strong>Free radicals play a key role in spinal cord injury and curcumin has the potential to act as an antioxidant agent. Controlled delivery of curcumin can be achieved through encapsulation in bovine serum albumin to form nanoparticles, and acellular scaffold can bridge lesions and improve axonal growth in spinal cord injury.</p><p><strong>Objective: </strong>In this study, we evaluated the antioxidant effects of the scaffold containing curcumin nanoparticles in the unilateral spinal cord injury model in male rats.</p><p><strong>Methods: </strong>Nanoparticles were prepared by the desolvation method and their characterization and efficiency were evaluated. The acellular scaffolds were prepared by using physical and chemical methods and for confirming the acellularization process, histological analysis was performed. After conjugating the nanoparticles with acellular scaffolds, 48 male Wistar rats were divided into four groups as follows: (1) Laminectomy group, (2) Spinal cord injury group, (3) Blank-acellular scaffold group and (4) Curcumin nanoparticles-acellular scaffold group. Functional recovery was assessed by measuring parameters such as MDA, GSH, SOD, and TAC.</p><p><strong>Results: </strong>The results showed that the mean size of the nanoparticles was 226 nm, and the zeta potential was -18.28. Curcumin nanoparticles-acellular scaffold group exhibited a significant decrease in the level of MDA and a meaningful increase in the levels of other parameters compared to spinal cord injury group (<i>p</i> = 0.000).</p><p><strong>Conclusion: </strong>The scaffold containing curcumin nanoparticles demonstrated a significant improvement in functional recovery after spinal cord injury. In this research, oxidative stress resulting from spinal cord injury was attenuated by treatment with a scaffold containing curcumin nanoparticles.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the correlation between the longitudinal trajectories of blood urea nitrogen and 30-day survival in hemorrhagic stroke patients.","authors":"Celin Guan, Tao Chen, Folin Lan, Xinhong Su, Zhiqin Lin, Jinliang Zheng","doi":"10.1080/01616412.2025.2551091","DOIUrl":"https://doi.org/10.1080/01616412.2025.2551091","url":null,"abstract":"<p><strong>Background: </strong>While some studies suggest a link between blood urea nitrogen (BUN) levels and adverse outcomes in hemorrhagic stroke (HS) patients, the prognostic value of longitudinal BUN changes remains unclear.</p><p><strong>Objective: </strong>To evaluate the association between longitudinal BUN trajectories and 30-day mortality risk in HS patients.</p><p><strong>Methods: </strong>We analyzed HS patients from the MIMIC-IV database diagnosed within 24 hours of hospitalization. Group-based trajectory modeling (GBTM) was used to identify BUN trajectories. Kaplan-Meier survival curves and Cox proportional hazards models were employed to assess mortality risk, while ROC curves evaluated BUN's predictive accuracy.</p><p><strong>Results: </strong>Among 1,172 HS patients, three distinct BUN trajectories were identified. Patients with rising BUN trends (Class 2 and 3) had significantly higher 30-day mortality risks compared to those with stable BUN levels (Class 1) (HR > 1, <i>p</i> < 0.001), with Class 3 patients exhibiting the worst outcomes. ROC analysis demonstrated strong predictive accuracy for mortality, with AUC values of 0.866, 0.841, and 0.841 at 7, 14, and 30 days, respectively, after adjusting for confounders.</p><p><strong>Conclusion: </strong>Persistently elevated BUN trajectories are independently associated with increased 30-day mortality in HS patients. This study highlights the heterogeneity of BUN trajectories in HS, providing insights beyond baseline BUN measurements and enhancing understanding of HS progression.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular thrombectomy in young patients with acute vertebrobasilar artery occlusion.","authors":"Zhiwen Geng, Juan Du, Chengcheng Cui, Lulu Xiao, Qingting Hu, Wen Sun, Wenya Lan, Chengqun Wei","doi":"10.1080/01616412.2025.2549034","DOIUrl":"https://doi.org/10.1080/01616412.2025.2549034","url":null,"abstract":"<p><strong>Background and purpose: </strong>Data on endovascular thrombectomy (EVT) for acute vertebrobasilar artery occlusion (VBAO) in young adults are limited. We compared clinical characteristics and outcomes after EVT between young and older patients.</p><p><strong>Methods: </strong>Using a multicenter retrospective registry, we analyzed patients undergoing EVT for acute VBAO. Patients were dichotomized by age (18-44 years vs ≥ 45 years). Primary outcomes were functional independence (modified Rankin Scale score, mRS 0-2) at 90 days and 1 year. Secondary outcomes included successful reperfusion, 24-hour/discharge National Institute of Health Stroke Scale (NIHSS) scores, early neurological function changes, 90-day/1-year mRS distributions, symptomatic intracranial hemorrhage (sICH), and mortality. Multivariable logistic regression adjusted for confounders assessed associations. Interaction effects between age group and hypertension/diabetes/atrial fibrillation were evaluated.</p><p><strong>Results: </strong>Among 518 patients, 37 (7.1%) were aged 18-44 years. Young patients had fewer cardiovascular comorbidities. Etiologies were more heterogeneous in young patients (large-artery atherosclerosis: 35.1%, other determined cause: 35.1%). Young patients more frequently achieved early neurological improvement and functional independence at 90 days and 1 year (unadjusted). Adjusted analyses showed age dichotomization was not significantly associated with 90-day (aOR 1.15, 95% CI 0.50-2.64, <i>p</i> = 0.74) or 1-year (aOR 1.59, 95% CI 0.68-3.72, <i>p</i> = 0.286) functional independence. A significant hypertension-by-age interaction existed for 90-day functional independence (<i>p</i> = 0.014), and no significant interactions were found for other comorbidities or at 1 year. Mortality and sICH rates were comparable between the two groups.</p><p><strong>Conclusions: </strong>EVT demonstrates comparable efficacy in young and older VBAO patients, underscoring its critical value especially for young patients with more heterogeneous etiologies.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of autophagy-related biomarkers in the circulatory system of ischemic stroke.","authors":"Yuyu Xu, Jinshan Duan, Deling Zhong, Ming Yuan, Guohai Zhang, Zheli Zhu, Yani Xie","doi":"10.1080/01616412.2025.2556537","DOIUrl":"https://doi.org/10.1080/01616412.2025.2556537","url":null,"abstract":"<p><strong>Objectives: </strong>Increasing evidence indicates autophagy's dual role in ischemic stroke (IS), though its mechanisms and biomarkers remain unclear. This study analyzes autophagy-related genes (ARGs) and constructs a circRNA-miRNA-mRNA network to identify key ARGs and their interactions.</p><p><strong>Materials and methods: </strong>Differentially expressed genes from GEO were intersected with HADb-derived autophagy-related genes (ARGs) to identify DEARGs. Target mRNAs of DEmiRNAs and DEcircRNAs were predicted via mirDIP and circBank, respectively, and integrated to construct a circRNA-miRNA-mRNA regulatory network. Key genes were screened through PPI analysis, followed by immune infiltration analysis and experimental validation.</p><p><strong>Results: </strong>In IS, 539 circRNAs, 61 miRNAs, and 565 mRNAs were identified with differential expression. A circRNA-miRNA-autophagy related mRNA network was established, identifying multiple regulatory relationship pairs. Notably, five autophagy-related hub genes demonstrated significant correlations with immune cell infiltration. Clinical validation further confirmed that (HIF1A) and (EIF2AK2) were significantly upregulated, while (HSPA8) was significantly downregulated, underscoring their potential relevance in IS.</p><p><strong>Conclusion: </strong>HIF1A, EIF2AK2, and HSPA8 May serve as biomarkers for early diagnosis of IS. This study reveals fresh insights into the molecular mechanisms linked to IS.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of thymoquinone on hippocampal spexin levels in cisplatin-induced rats.","authors":"Tuba Yalçin, Sercan Kaya","doi":"10.1080/01616412.2025.2504158","DOIUrl":"10.1080/01616412.2025.2504158","url":null,"abstract":"<p><p>Neurotoxicity is a known side effect of the chemotherapeutic drug cisplatin (CIS). Thymoquinone (THQ) is a natural compound with strong neuroprotective, antioxidant, and anti-inflammatory effects. The objective of this study is to ascertain the impact of CIS on histopathological, biochemical, and spexin (SPX) immunoreactivity in the hippocampus, and to determine whether THQ has a protective role against these effects.Twenty-eight male Sprague - Dawley rats (8-10 weeks old,200 ± 20 g) were used in the study and randomly divided into four groups (<i>n</i> = 7): control (no administration), CIS (7 mg/kg on the first day), CIS+THQ (7 mg/kg CIS on the first day + 10 mg/kg/day THQ), and THQ (10 mg/kg/day THQ). On the 15th day, the rats were sacrificed. Hippocampus tissue samples were used for biochemical, histological, and immunohistochemical analyses. CISadministration significantly increased interleukin-6 (IL-6), malondialdehyde(MDA), histopathological changes, and SPX immunoreactivity in the hippocampus.THQ treatment was found to significantly reduce the adverse effects of.THQ treatment demonstrated neuroprotective effects againstCIS-induced damage in the hippocampus by modulating antioxidant activity, inflammatory response, and SPX immunoreactivity. We suggest that SPX, whose role and mechanism of action in cognitive, physiological, and pathological processes remains unclear, plays an active role in hippocampus-related functions. Further and more comprehensive studies on SPX are warranted.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"817-825"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring neuroprotective effects of PP2 in ischemic stroke via bioinformatics and experimental validation.","authors":"Shiyan Zhao, Jun Lu, Yanyan Zhao, Chang Qi, Chunrong Han","doi":"10.1080/01616412.2025.2505242","DOIUrl":"10.1080/01616412.2025.2505242","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke is a leading cause of mortality and disability worldwide, yet effective therapeutic options remain limited. In this study, bioinformatics analyses were used to identify potential therapeutic targets and small-molecule compounds for ischemic stroke. A mouse model of cerebral ischemia was subsequently used to validate their neuroprotective efficacy.</p><p><strong>Methods: </strong>Bioinformatics methods were used to analyze and identify key signaling pathways and hub genes associated with ischemic stroke. Additionally, the Connectivity Map (CMap) database was queried to identify potential small-molecule compounds for ischemic stroke treatment. Finally, a middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model was employed to further evaluate the neuroprotective effects of the identified compounds.</p><p><strong>Results: </strong>GO and KEGG pathway enrichment analyses revealed that key signaling pathways such as TNF, NF-κB, and IL-17 play crucial roles in ischemic stroke. PPI network analysis identified five hub genes-IL-1β, IL-6, ICAM-1, Jun, and Fos-all closely associated with neuroinflammatory responses. The small-molecule compound PP2, a selective Src kinase inhibitor, was identified by CMap database. In the MCAO/R mouse model, PP2 exhibited significant neuroprotective effects. It reduced infarct volume and brain edema and improved neurological function. Mechanistically, PP2 inhibited Src phosphorylation, thereby suppressing the NF-κB signaling pathway and reducing levels of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6.</p><p><strong>Conclusion: </strong>This study identifies Src kinase as a promising therapeutic target for ischemic stroke and highlights the value of bioinformatics in drug discovery and mechanistic research.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"864-875"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering diabetic neuropathy: immune cell causality revealed.","authors":"Yunfeng Yu, Xinyu Yang, Yuman Yin, Juan Deng, Cong Chen, Rong Yu","doi":"10.1080/01616412.2025.2503456","DOIUrl":"https://doi.org/10.1080/01616412.2025.2503456","url":null,"abstract":"<p><strong>Objective: </strong>This study assessed the causal effects of immune cell phenotypes on diabetic neuropathy (DN) using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>Datasets of immune cell phenotypes and DN were collected from the European Bioinformatics Institute and FinnGen. Single nucleotide polymorphisms that met the specified criteria were subjected to a stepwise selection based on the hypotheses of association, independence, and exclusivity. Inverse variance weighted was employed as the main tool for MR analysis. Horizontal pleiotropy, heterogeneity, and robustness of the MR results were evaluated using the MR-Egger intercept, Cochran's Q, and leave-one-out sensitivity analyses, respectively.</p><p><strong>Results: </strong>MR analysis revealed that CD24+CD27+ %lymphocyte (odds ratio [OR]: 1.043, 95% confidence interval [CI]: 1.007‒1.080, <i>p</i> = 0.018, false discovery rate [FDR] = 0.998), CD24+CD27+ AC (OR: 1.041, 95% CI: 1.004‒1.079, <i>p</i> = 0.030, FDR = 0.998), CD28-CD127-CD25++CD8br %T cell (OR: 1.069, 95% CI: 1.003‒1.140, <i>p</i> = 0.042, FDR = 0.998), CD28-CD25++CD8br AC (OR: 1.095, 95% CI: 1.019‒1.177, <i>p</i> = 0.014, FDR = 0.998), CD33-HLA DR - AC (OR: 1.079, 95% CI: 1.007‒1.156, <i>p</i> = 0.031, FDR = 0.998), CD8 on CM CD8br (OR: 1.135, 95% CI: 1.012‒1.273, <i>p</i> = 0.030, FDR = 0.998), and naïve CD4+ %CD4+ (OR: 1.119, 95% CI: 1.030‒1.215, <i>p</i> = 0.008, FDR = 0.787) were associated with increased genetic susceptibility to DN. The MR-Egger intercept analysis indicated the absence of horizontal pleiotropy (<i>p</i> ≥ 0.05) and Cochran's Q test showed that the results were not heterogeneous (<i>p</i> ≥ 0.05).</p><p><strong>Conclusion: </strong>This MR analysis revealed seven immune cell phenotypes associated with increased genetic susceptibility to DN. These findings are preliminary and warrant further experimental validation in different populations to confirm their significance.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":"47 9","pages":"782-790"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between white matter hyperintensity and atherogenic index of plasma in migraine.","authors":"Gulhan Sarıcam, Fahrettin Ege, Memet Aslanyavrusu","doi":"10.1080/01616412.2025.2502784","DOIUrl":"10.1080/01616412.2025.2502784","url":null,"abstract":"<p><strong>Objective: </strong>White matter hyperintensities (WMH) are more commonly observed in patients with migraine compared to the general population; however, their pathophysiology remains incompletely understood. This study aims to investigate the relationship between the atherogenic index of plasma (AIP), a vascular risk marker, and WMH in patients with migraine.</p><p><strong>Methods: </strong>This study included 274 patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-III). The relationship between WMH and AIP in migraine patients was validated by Two-State Logistic Regression Analysis, and the cubic spline curve was used to determine linearity.</p><p><strong>Results: </strong>The mean age of the patients with migraine was 36.26 ± 8.37 years and 82.8% (<i>n</i> = 227) were female. The the prevalence of aura (<i>p</i> = 0.028), age (<i>p</i> = 0.001) and mean disease duration (<i>p</i> < 0.001, <i>t</i>=-4.257) were significantly higher in migraine patients with WMH than those without WMH. AIP (<i>p</i> < 0.001, <i>t</i>=-6.667), triglyceride (TG) (<i>p</i> < 0.001, <i>t</i>=-5.736) and body mass index (BMI) (<i>p</i> = 0.020, <i>t</i>=-2.344) were significantly higher in patients with WMH compared to those without WMH. A two-state regression analysis demonstrated a linear relationship between increased AIP (OR:7.101, 95% CI:3.417-14.174), TG (OR: 1.016, 95% CI: 1.005-2.023) and WHM in patients with migraine.</p><p><strong>Conclusion: </strong>In our study, we found positive correlation between WMH and AIP values in patients with migraine, and showed that AIP values were a statistically significant discriminator of WMH. Our results suggest that the AIP can be used as a cost-effective and significant marker for determining WMH in patients with migraine.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"773-781"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}