Neurological Research最新文献

{"title":"The significance of neural electrophysiological and functional effects of cervical spinal ganglia and sympathetic ganglia in cervical vertigo.","authors":"Gang Chang, Jianlong Han, Jinliang Zuo, Yong Meng, Qiang Wang, Siqiang Qiu","doi":"10.1080/01616412.2024.2448631","DOIUrl":"https://doi.org/10.1080/01616412.2024.2448631","url":null,"abstract":"<p><p>This study investigates the neural electrophysiological and functional effects of cervical spinal ganglia and sympathetic ganglia in cervical vertigo. Twenty-eight rabbits were randomized into superior cervical sympathetic ganglia (SCSG) group (n = 8), inferior cervical sympathetic ganglia (ICSG) group (n = 8) and control groups for both SCSG and ICSG (n = 6 each). Calcium indicator CaMPARI2 was injected into the ganglia. Four weeks later, both SCSG and ICSG groups underwent electrical stimulation followed by UV irradiation. Control groups did not receive electrical stimulation but were also injected with the calcium indicator and irradiated by UV. Additionally, 63 rabbits were randomized into three groups: cervical spinal ganglia stimulation (n = 21), paravertebral nerve blockage (n = 21), and simultaneous blockage of paravertebral nerve and cervical spinal ganglia (n = 21), all subjected to the same electrical stimulation protocol. Results indicated that calcium concentration in the cervical sympathetic ganglia after stimulation was significantly higher compared to the control group (P < 0.05). Blood flow changes in both vertebral artery and basilar artery were significant after electrical stimulation (P < 0.05). In the paravertebral nerve blockage group, significant changes in basilar artery blood flow were observed (P < 0.05), while no significant blood flow changes were noted in the simultaneous blockage group. Cervical spinal ganglia and sympathetic ganglia in the pathogenesis of cervical vertigoThese findings underscore the importance of neural electrophysiological and functional effects of cervical spinal ganglia and sympathetic ganglia in the pathogenesis of cervical vertigo.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELK3 expression as a prognostic marker in patients with glioma.","authors":"Shanquan Jing, Li Wang, Wei Liu, Conghui Li","doi":"10.1080/01616412.2025.2490088","DOIUrl":"https://doi.org/10.1080/01616412.2025.2490088","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to elucidate the expression and clinical relevance of ELK3 in gliomas and to predict its biological functions using comprehensive database analyses.</p><p><strong>Methods: </strong>We utilized data from glioma patients in the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) to investigate ELK3 expression across different tumor grades. The impact of ELK3 expression on patient survival was evaluated using Kaplan-Meier survival analysis, and both univariate and multivariate Cox regression analyses. Additionally, Pearson correlation analysis identified genes associated with ELK3 expression, and these genes underwent functional enrichment analysis via Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG).</p><p><strong>Results: </strong>Our findings demonstrate a positive correlation between ELK3 expression and glioma grade, with significant differences in expression observed across grades II, III, and IV (<i>p</i> < 0.05). Elevated ELK3 expression was associated with poorer patient outcomes (<i>p</i> < 0.05). Analyses from both CGGA and TCGA confirmed ELK3 as an independent prognostic factor for gliomas. Functional enrichment analysis revealed significant associations of ELK3 with critical immune-related pathways, including neutrophil activation, T cell activation, and antigen presentation.</p><p><strong>Conclusion: </strong>ELK3 is established as an independent prognostic marker in gliomas, intimately linked with pivotal immune-related pathways. These insights highlight the potential of ELK3 as both a biomarker and a therapeutic target in the management of glioma, offering avenues for improved prognostic assessments and therapeutic strategies.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in use of gabapentinoids among adults in the United States from 2003-2018.","authors":"Hok Leong Chin","doi":"10.1080/01616412.2025.2490091","DOIUrl":"https://doi.org/10.1080/01616412.2025.2490091","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the prevalence and trends in gabapentinoid use among the US population. It also aimed to contribute to the current literature by providing additional context across different sociodemographic subgroups.</p><p><strong>Methods: </strong>This study utilized data from the 2003-2004 cycles to the 2017-2018 cycles, including a total of 115,554 participants aged 20 years and older. Gabapentinoid use was determined through a questionnaire that inquired about prescription medication use during the past 30 days. Analyses were weighted and conducted using STATA/SE version 17.0. Trends were assessed using logistic regression.</p><p><strong>Results: </strong>Gabapentinoid use significantly increased from 0.6% (95% CI, 0.4%-0.7%) in 2003-2004 to 1.8% (95% CI, 1.6%-2.0%) in 2017-2018, primarily driven by increased gabapentin utilization. The trends were similar across different subgroups.</p><p><strong>Conclusions: </strong>The findings revealed a substantial rise in gabapentinoid use, particularly gabapentin, aligned with other studies. Safety concerns are underscored, emphasizing the potential for abuse and misuse, especially amid the opioid epidemic.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-4"},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of cavernous internal carotid artery tortuosity on mechanical thrombectomy outcomes: analysis of a single center 5-year cohort and validation of prior scales.","authors":"John Engelbert, David P Babcock, Robert Hand, John T Tsiang, Ronak Jani, Brandon J Bond, Anthony Kam, David Pasquale, Joseph C Serrone","doi":"10.1080/01616412.2025.2490083","DOIUrl":"https://doi.org/10.1080/01616412.2025.2490083","url":null,"abstract":"<p><strong>Introduction: </strong>Tortuosity of the cavernous internal carotid artery (cICA) complicates neuro-endovascular access. Improved assessment of cICA tortuosity could improve procedural outcomes. This study attempts to refine cICA tortuosity classification through analysis of its effect on mechanical thrombectomy (MT) outcomes and to externally validate previously scales.</p><p><strong>Methods: </strong>Retrospective single center review of 191 patients who underwent transfemoral anterior circulation MT over 5 years. Four parameters of cICA tortuosity were measured. Regression analysis was performed on cICA parameters influencing first pass revascularization success and time to revascularization. Significant cICA parameters were then divided into a 3-tier ordinal scale. Three existing cICA tortuosity scales (Lang-Reiter, Lin, and Chen) were similarly analyzed. All scales were compared using area under receiver operator characteristic curve (AUROC).</p><p><strong>Results: </strong>None of the cICA parameters were associated with first pass success. Revascularization times were longer with higher true genu height (TGH) (<i>p</i> = 0.04) and lower posterior genu angle (PGA) (<i>p</i> = 0.04). TGH and PGA had a strong inverse correlation. In predicting revascularization time, the TGH and PGA scales found statistically significant differences when comparing mild versus severe classifications. The Lin, Chen, and TGH scales found statistically significant differences between their mild versus moderate classifications. AUROC for all scales ranged from 0.57 to 0.59 for first pass success with Chen, TGH, and PGA scales statistically superior to chance.</p><p><strong>Conclusions: </strong>Two single metrics obtained on lateral angiography, TGH and PGA, performed as well as more complex scales for predicting MT outcomes. Further external validation of these metrics is warranted.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of proprioceptive neuromuscular facilitation techniques on pain, motor functions, fatigue and health related quality of life in individuals with multiple sclerosis: a randomized, single-blind study.","authors":"Bircan Yucekaya, Seda Nur Kemer, Elif Asan, Huseyin Gerdan, Nilay Comuk Balci, Deniz Cakır, Mine Pekesen Kurtça, Murat Keskin, Murat Terzi","doi":"10.1080/01616412.2025.2490086","DOIUrl":"https://doi.org/10.1080/01616412.2025.2490086","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effects of PNF on pain, motor function, fatigue, and quality of life in MS patients.</p><p><strong>Method: </strong>A randomized, controlled, single-blind study was conducted. Forty-four patients were randomly assigned to either the PNF Group (PNFG, <i>n</i> = 22, 16 female) or the Control Group (CG, <i>n</i> = 22, 16 female). PNFG underwent supervised combined aerobic and PNF training thrice weekly for 8 weeks, while CG followed a home exercise regimen. Various measures were employed, including the Visual Analogue Scale (VAS) for pain, Timed Up and Go (TUG) test, Functional Reach Test (FRT), Six-Minute Walk Test (6-MWT), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS), Dexterity Questionnaire-24 (DextQ-24) and Multiple Sclerosis Quality of Life-54 (MSQoL-54).</p><p><strong>Results: </strong>PNFG exhibited significant improvements in VAS (<i>p</i> = 0.000), FRT (<i>p</i> = 0.001), TUG (<i>p</i> = 0.000), 6-MWT (<i>p</i> = 0.000), FIS (<i>p</i> = 0.007), DextQ-24 (<i>p</i> = 0.033), MSQoL-54 scores (Physical Health Composite, Mental Health Composite, <i>p</i> = 0.005, <i>p</i> = 0.002, respectively) (<i>p</i> < 0.05). CG also showed improvements in VAS (<i>p</i> = 0.018), TUG (<i>p</i> = 0.000), 6-MWT (<i>p</i> = 0.000), FSS (<i>p</i> = 0.006), psychosocial function (<i>p</i> = 0.007), MSQoL-54 (Physical Health Composite, Mental Health Composite, <i>p</i> = 0.017, <i>p</i> = 0.001, respectively), DextQ-24 ADL scores (<i>p</i> = 0.045) (<i>p</i> < 0.05). PNFG outperformed CG in DextQ-24 (Dressing, <i>p</i> = 0.038) and MSQoL-54 subscales (emotional well-being, energy, health perception, <i>p</i> = 0.007, <i>p</i> = 0.037, <i>p</i> = 0.044, respectively) (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>This is the first randomized controlled trial to show that PNF improves upper limb motor function (skill) and quality of life in MS patients. PNF and home physiotherapy effectively improved pain, motor function, fatigue and quality of life, with the PNF group achieving better outcomes. Both modalities offered accessible rehabilitation options.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediators of the causal associations between protein ratios and ischemic stroke: a two-step Mendelian randomization study.","authors":"Haozhou Tan, Hao Chen, Han Yan, Fangfang Li, Yang Yao, Ying Li, Qian Feng","doi":"10.1080/01616412.2025.2487867","DOIUrl":"https://doi.org/10.1080/01616412.2025.2487867","url":null,"abstract":"<p><strong>Background: </strong>Proteomics has revealed links between plasma proteins and ischemic stroke (IS), but the relationship between protein ratios, IS, and the effects of blood cells and serum uric acid (SUA) is underexplored.</p><p><strong>Methods: </strong>Using two-sample Mendelian randomization (MR), we assessed causal relationships between 2,821 protein ratios, 91 blood phenotypes, SUA, and IS subtypes. FDR correction was applied specifically to protein ratio analyses to account for multiple comparisons in the primary MR step. Significant associations were further validated through co-localization analysis, which assessed shared genetic architecture between exposure and outcome loci. This analysis used GWAS data from MEGASTROKE, GISCOME, minimizing confounding bias and reverse causation. Additionally, the total effects of protein ratio levels on IS were decomposed into direct and indirect effects mediated through multiple pathways. Sensitivity analyses ensured robustness.</p><p><strong>Results: </strong>The CD34/ITGAV ratio exhibited distinct effects on stroke risk, showing 34.9% increased odds of LAS (OR=1.349, 95% CI=1.097-1.658) while demonstrating protective effects against IS outcome progression (OR=0.564, 95% CI=0.380-0.838). Bayesian co-localization analysis revealed complete genetic overlap (PPH4 = 1) for key protein ratio-stroke subtype pairs: AIS with TGFBR2/THBD ratio, LAS with LGALS8/VWF ratio, CES with BST2/CEACAM1 and CD209/CLEC4G ratios. In mediation pathways, neutrophil parameters accounted for 54.4% of the prognosis effect in the ABHD14B/STAMBP-IS association, whereas SUA mediated only 1.3% of the PODXL2/SDC1 ratio-IS relationship.</p><p><strong>Conclusions: </strong>Our MR study combined with co-localization analysis identifies causal links between protein interactions and IS, highlighting potential targets to disrupt pathways connecting protein ratio changes to IS incidence and outcomes, offering promising intervention avenues.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor genomics and clinical methylation.","authors":"David S Hersh, Karishma Bulsara, Kevin Becker, Qian Wu, Ketan R Bulsara","doi":"10.1080/01616412.2025.2486521","DOIUrl":"https://doi.org/10.1080/01616412.2025.2486521","url":null,"abstract":"<p><p>Next-generation sequencing and clinical methylation were explored as evolving necessities for personalized medicine to augment surgery. The routine integration of these technologies into patient care has heralded an age of precision tumor treatment. This personalization of treatment and precision of diagnosis afforded by it will likely to lead to improved outcomes.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-3"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?","authors":"Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge","doi":"10.1080/01616412.2025.2472828","DOIUrl":"10.1080/01616412.2025.2472828","url":null,"abstract":"<p><strong>Objectives: </strong>Motor unit number estimation (MUNE) methods including the one using F-waves (F-MUNE) are used to detect axonal loss in polyneuropathies. The aim of this study is to evaluate the amount of axonal loss by repeater F-wave parameters and F-MUNE in patients with type 2 diabetes mellitus (DM).</p><p><strong>Methods: </strong>In 24 controls and 49 patients with diabetic polyneuropathy, 90 F-waves elicited with supramaximal and 300 F-waves with submaximal stimulation of the ulnar nerve were recorded from the abductor digiti minimi muscle. F-MUNE values were calculated using the automated software with the repeater F-waves elicited using submaximal stimulation.</p><p><strong>Results: </strong>Ulnar repeater F-wave index and repeater neuron index were found to be significantly higher in patients with DM compared with the control group. The amplitudes of F-waves elicited using both sub- and supramaximal stimulus intensities were reduced in patients with polyneuropathy when compared with controls. The F-MUNE values were found to be similar between the two groups.</p><p><strong>Discussion: </strong>Repeater F-wave parameters recorded from the upper extremity might indicate the presence of axon loss in DM-related polyneuropathy. However, F-MUNE failed to reveal axonal loss in diabetic polyneuropathy probably because of its length-dependent nature and the dominance of low-amplitude F-waves, which might be secondary to several yet unknown mechanisms, mainly related to sensory fiber dysfunction.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"258-266"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the balance recovery and the independence after a severe stroke.","authors":"Christian Gath, Vanina Lado, Matías Gianella, Lucas Bonamico, María J Russo","doi":"10.1080/01616412.2025.2472835","DOIUrl":"10.1080/01616412.2025.2472835","url":null,"abstract":"<p><strong>Objectives: </strong>Research is lacking on the recovery of subjects who have suffered a stroke and have severely impaired balance in the subacute stage. This study aims to analyze the association between balance recovery during inpatient rehabilitation and the level of independence in activities of daily living at discharge in severe subacute stroke patients. Secondarily, it aims to analyze the association between balance at the admission of inpatient rehabilitation after stroke and the level of independence in activities of daily living at discharge in the same sample.</p><p><strong>Methods: </strong>A longitudinal retrospective observational cohort study was conducted. Subacute post-stroke patients who could not stand at admission were included (<i>n</i> = 80). A correlation analysis was undertaken. The Functional Independence Measure was used to evaluate activities of daily living performance and the Berg Balance Scale to assess balance.</p><p><strong>Results: </strong>Correlation between balance recovery during inpatient rehabilitation and the level of independence at discharge: Spearman's rho = 0.741 (<i>p</i> < 0.001). Correlation between the Balance at admission and the level of independence at discharge: Spearman's rho = 0.288 (<i>p</i> = 0.009).</p><p><strong>Discussion: </strong>Monitoring balance recovery after a severe stroke may be necessary to establish functional goals during inpatient rehabilitation. Low functional independence at discharge from inpatient rehabilitation post stroke cannot always be expected in subjects with severe balance impairment at admission.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"277-283"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.","authors":"Ali Mojaver, Mojtaba Khazaei, Mohammad Ahmadpanah, Mohammad Zarei, Sara Soleimani Asl, Parisa Habibi, Siamak Shahidi","doi":"10.1080/01616412.2025.2470712","DOIUrl":"10.1080/01616412.2025.2470712","url":null,"abstract":"<p><strong>Objectives: </strong>Ischemic stroke is one of the most common neurological disorders. Oxidative stress, inflammation, and the reduction of Brain-Derived Neurotrophic Factor (BDNF) are implicated in cell death during ischemic stroke. Several studies suggest that Coenzyme Q10 (CoQ10) has antioxidant, anti-inflammatory, neuroprotective properties and can increase BDNF levels. This study investigated the effects of oral CoQ10 supplementation on oxidative stress biomarkers Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), Malondialdehyde (MDA), Total Thiol Groups (TTG) - as well as serum levels of Interleukin-6 (IL-6) and BDNF in ischemic stroke patients.</p><p><strong>Methods: </strong>Fifty patients hospitalized for acute ischemic stroke were randomly divided into two groups: placebo (<i>n</i> = 25) and CoQ10 (600 mg/day) supplementation (<i>n</i> = 25). The intervention began 24 hours after stroke onset and continued for 30 days.</p><p><strong>Results: </strong>Significant reductions in serum MDA and IL-6 levels, alongside increased SOD and BDNF levels, were observed in the CoQ10 group. No significant differences were found in TAC or TTG levels between the groups.</p><p><strong>Conclusions: </strong>A 30-day regimen of CoQ10 (600 mg/day) resulted in reduced oxidative stress and inflammation, alongside increased BDNF, suggesting potential neuroprotective benefits for post-stroke rehabilitation. CoQ10 May be considered a therapeutic option for enhancing neuroprotection and rehabilitation in stroke patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"232-241"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}