Neurological Research最新文献

Identification of Alzheimer's disease susceptibility genes by the integration of genomics and transcriptomics. 结合基因组学和转录组学鉴定阿尔茨海默病易感基因。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-07 DOI: 10.1080/01616412.2025.2499890

Chenghong OuYang, Hanping Shi, Zhiying Lin

{"title":"Identification of Alzheimer's disease susceptibility genes by the integration of genomics and transcriptomics.","authors":"Chenghong OuYang, Hanping Shi, Zhiying Lin","doi":"10.1080/01616412.2025.2499890","DOIUrl":"10.1080/01616412.2025.2499890","url":null,"abstract":"Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease. With the deepening of clinical and genomic research, a series of biomarkers and risk factors related to AD have been identified. However, the exact molecular mechanism of AD is not completely understood.Methods: By combining expression quantitative trait loci (eQTLs) analysis with the results of genome-wide association studies (GWAS), the candidate genes (CG) related to AD were screened out accurately. We identified that intersection genes of differentially expressed genes (DEGs) and CG are the key genes. Then, GO, KEGG, and GSEA were utilized for functional enrichment analysis. Finally, we predicted AD responses to immunotherapy by the single sample gene set enrichment analysis (ssGSEA).Results: A total of 253 DEGs were identified. The three key genes (VASP, SURF2, and TARBP1) were identified by taking the intersection of DEGs and CG. Through Mendelian randomization (MR) analysis, it was found that the risk of AD was significantly increased when VASP expression increased (OR = 0.1.046), while the risk of AD was significantly decreased when SURF2 (OR = 0.897) and TARBP1(OR = 0.920) expression increased. Subsequently, the functional analysis indicated that the core genes were mainly enriched in Leukocyte Transendothelial Migration, cGMP-PKG signaling pathway, and Rap1 signaling pathway. Through ssGSEA analysis showed that all three core genes were significantly related to M2 macrophages.Conclusions: Three core genes were screened by integrating eQTLs data, GWAS data and transfer group data, and the potential mechanism of diagnosis and treatment of AD was revealed.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"732-744"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of topically applied sodium-2-mercaptoethanesulfonate (MESNA) in the prevention of epidural fibrosis following lumbar laminectomy in rats. 局部应用2-巯基乙磺酸钠（MESNA）预防大鼠腰椎椎板切除术后硬膜外纤维化的作用。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1080/01616412.2025.2498688

Erdal Resit Yilmaz, Ekrem Yalcin, Ata Turker Arikok, Muhammed Erkan Emrahoglu, Habibullah Olgun, Eylem Eren Eyupoglu, Askin Esen Hasturk

{"title":"Effects of topically applied sodium-2-mercaptoethanesulfonate (MESNA) in the prevention of epidural fibrosis following lumbar laminectomy in rats.","authors":"Erdal Resit Yilmaz, Ekrem Yalcin, Ata Turker Arikok, Muhammed Erkan Emrahoglu, Habibullah Olgun, Eylem Eren Eyupoglu, Askin Esen Hasturk","doi":"10.1080/01616412.2025.2498688","DOIUrl":"10.1080/01616412.2025.2498688","url":null,"abstract":"Objective: In spinal surgery practices through which nervous tissues are released as a result of decompression, the occurrence of fibrosis is a substantial issue that reduces the success rates. This study investigated the positive impacts of topical application of sodium-2-mercaptoethanesulfonate (MESNA) on the prevention of fibrosis at the surgical site.Material and methods: All groups were anesthetized 4 weeks after the procedure, and they were subjected to neuromonitoring. Subsequently, after the rats were killed, the development of fibrosis was evaluated in a macroscopic manner by creating a surgical site through the previous incision. The left L4 root was excised along with its peripheral tissue, and the prevalence of the fibrosis was evaluated microscopically.Results: The fibrous tissue was observed to be less prevalent in the group where MESNA was applied, as per the macroscopic and histopathologic scoring.Conclusion: The positive macroscopic and microscopic effectiveness of the topically applied MESNA solution to prevent fibrosis was demonstrated. Further research is needed to substantiate this potential of MESNA.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"723-731"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atraumatic mandibular fossa perforation: a report of two cases and literature review. 非外伤性下颌窝穿孔2例报告并文献复习。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-04-24 DOI: 10.1080/01616412.2025.2497478

Ketan Bulsara, Taylor Burch, Timothy Parke, Karishma Bulsara, David M Shafer

引用次数: 0

Effect of pain-related sodium channels SCN9A and SCN10A polymorphisms in migraine chronification. 疼痛相关钠通道SCN9A和SCN10A多态性在偏头痛慢性化中的作用。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-10 DOI: 10.1080/01616412.2025.2497480

Erhan Kilic, Ceyda Colakoglu- Bergel, Isil Ezgi Eryilmaz, Emel Oguz-Akarsu, Unal Egeli, Cigdem Sevda Erer-Ozbek, Deniz Sigirli, Rumeysa Fatma Balaban, Ebrucan Bulut, Gulsah Cecener, Mehmet Zarifoglu, Hamdi Necdet Karli

{"title":"Effect of pain-related sodium channels SCN9A and SCN10A polymorphisms in migraine chronification.","authors":"Erhan Kilic, Ceyda Colakoglu- Bergel, Isil Ezgi Eryilmaz, Emel Oguz-Akarsu, Unal Egeli, Cigdem Sevda Erer-Ozbek, Deniz Sigirli, Rumeysa Fatma Balaban, Ebrucan Bulut, Gulsah Cecener, Mehmet Zarifoglu, Hamdi Necdet Karli","doi":"10.1080/01616412.2025.2497480","DOIUrl":"10.1080/01616412.2025.2497480","url":null,"abstract":"Objective: Based on the frequency of attacks, migraine is classified into two subtypes: episodic (EM) and chronic (CM). Migraine progression from EM to CM is supposed to be affected by various factors, which is known as \"migraine chronification. However, the pathophysiology of migraine chronification is multifactorial and still not fully understood. Ion channels are hypothesized to play a role in migraine pathophysiology and are essential for generating and suppressing action potentials, which lie under the pain and related symptoms. Two sodium channel genes, SCN9A and SCN10A, have been reported to be associated with various pain sensitivities. Studies have shown that patients with EM and CM are more sensitive to chronic pain and that pain sensitivity may be a risk factor for chronification. Thus, the current study aimed to determine whether pain sensitivity-related SCN9A and SCN10A polymorphisms affect the EM-to-CM transition.Methods: For this purpose, genotyping was performed using TaqMan SNP Assay for the (i) SCN9A rs7595255, rs12622743, and rs11898284, (ii) SCN10A rs6795970, rs6801957 SNPs in Turkish EM and CM patients.Results: The results showed that SCN9A and SCN10A polymorphisms did not play a role in the development of chronicity. However, the results indicated that the SCN10A rs6795970 polymorphism was associated with osmophobia (p = 0.036).Conclusion: SCN10A rs6795970 polymorphism may be necessary to predict the EM-to-CM transition and identify therapeutic targets. However, further studies are required to confirm the osmophobia association of the SCN10A rs6795970 polymorphism and to investigate the role of these SNPs in chronification.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"698-709"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLU polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy. 多发性硬化症患者CLU多态性和血浆聚集蛋白水平：与残疾评分、进展率和fingolimod治疗相关

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-04-27 DOI: 10.1080/01616412.2025.2497477

Osman Oğuzhan Kılıç, Semra Mungan, Şeref Demirkaya, Birsen Can Demirdöğen

{"title":"CLU polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy.","authors":"Osman Oğuzhan Kılıç, Semra Mungan, Şeref Demirkaya, Birsen Can Demirdöğen","doi":"10.1080/01616412.2025.2497477","DOIUrl":"10.1080/01616412.2025.2497477","url":null,"abstract":"Objectives: Multiple sclerosis (MS) is a chronic, demyelinating disorder of the central nervous system that is widely accepted to result from a complex interplay of genetic and environmental factors. The involvement of clusterin in neurodegenerative and autoimmune diseases has been highlighted, but its role in MS remains unclear. This study aimed to investigate the association of four single nucleotide polymorphisms (SNPs) in the clusterin gene (CLU) with MS susceptibility.Methods: The study group consisted of 310 patients with RRMS (pwRRMS) and 310 controls. 25 treatment-naïve pwRRMS, 25 pwRRMS on fingolimod treatment and 25 controls composed a subgroup for further analysis. The genotypes of 4 CLU SNPs were determined using either restriction endonuclease digestion following PCR (rs11136000 & rs3087554) or the real-time PCR method using TaqMan genotyping assays (rs2279590 & rs1532278). Plasma clusterin concentration was determined by ELISA in the subgroup (n = 75).Results: Our results revealed that CLU rs3087554 C allele (p = .008) and TC + CC genotype were significantly associated with RRMS (p = .002). Furthermore, haplotype analysis has also shown that T-C-T-T haplotype was associated with RRMS (p < .001). Moreover, plasma clusterin concentrations were significantly higher in pwRRMS on fingolimod therapy compared to treatment-naïve pwRRMS and the control group. In addition, plasma clusterin concentration was increased in patients with rs11136000 & rs1532278 CC genotypes in the subgroup.Discussion: These findings suggest that CLU SNPs and plasma clusterin concentrations could serve as significant biomarkers at different stages of MS.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"677-691"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of wall enhancement on high-resolution magnetic resonance imaging with morphology and hemodynamics in unruptured intracranial aneurysms. 高分辨率磁共振成像壁增强与未破裂颅内动脉瘤形态学和血流动力学的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1080/01616412.2025.2497482

Cai Han Huang, Qi Li, Li Wen, Guang Xian Wang, Dong Zhang

{"title":"Association of wall enhancement on high-resolution magnetic resonance imaging with morphology and hemodynamics in unruptured intracranial aneurysms.","authors":"Cai Han Huang, Qi Li, Li Wen, Guang Xian Wang, Dong Zhang","doi":"10.1080/01616412.2025.2497482","DOIUrl":"10.1080/01616412.2025.2497482","url":null,"abstract":"Objective: To investigate the relationships between intracranial aneurysm (IA) wall enhancement (AWE) and aneurysm morphology and hemodynamic parameters.Methods: A total of 100 patients (112 unruptured aneurysms) were categorized by enhancement degree (significant, slight, no enhancement) and pattern (circumferential, partial, no enhancement). Morphological and AWE features were measured using enhanced high-resolution magnetic resonance images (HR-MRI). Computational fluid dynamics (CFD) was used to calculate hemodynamic parameters, including time-averaged wall shear stress (TAWSS), normalized time-averaged wall shear stress (NTAWSS), oscillatory shear index (OSI), gradient oscillatory number (GON), and relative residence time (RRT).Results: NTAWSS (p < 0.05), aspect ratio (AR, p < 0.01), and size ratio (SR, p < 0.01) showed significantly statistical difference among AWE groups. The significantly enhanced group had higher AR and SR and higher RRT but lower NTAWSS compared to non-enhanced and slightly enhanced groups. Enhancement ratio negatively correlated with NTAWSS (rs = -0.33, p < 0.001), OSI (rs = -0.28, p = 0.003), and positively correlated with the GON (rs = 0.22, p = 0.018) and RRT (rs = 0.31, p < 0.001) and SR (rs = 0.51, p < 0.001) and AR (rs = 0.48, p < 0.001).Conclusion: Aneurysmal morphological and hemodynamic features are related to the degree and extent of AWE. Unruptured IAs with more intense AWE are larger and have lower NTAWSS and higher RRT.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"710-722"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioethics of neurotechnologies: a field in effervescence. 神经技术的生命伦理学：一个沸腾的领域。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-23 DOI: 10.1080/01616412.2025.2499896

Robert A Moumdjian

引用次数: 0

A simple scoring to predict symptomatic intracranial hemorrhage after stroke thrombolysis: the EGAN score. 预测脑卒中溶栓后症状性颅内出血的简单评分：EGAN评分。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1080/01616412.2025.2495989

Beny Rilianto, Helda, Asri C Adisasmita, Lhuri Dwianti Rahmartani, Gea Pandhita, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Ita Muharram Sari

{"title":"A simple scoring to predict symptomatic intracranial hemorrhage after stroke thrombolysis: the EGAN score.","authors":"Beny Rilianto, Helda, Asri C Adisasmita, Lhuri Dwianti Rahmartani, Gea Pandhita, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Ita Muharram Sari","doi":"10.1080/01616412.2025.2495989","DOIUrl":"10.1080/01616412.2025.2495989","url":null,"abstract":"Background: Symptomatic intracranial hemorrhage (sICH) after intravenous thrombolysis represents a critical and fatal complication observed in acute ischemic stroke (AIS) patients. This study aims to establish a simple scoring model to predict sICH.Methods: We retrospectively conducted a cohort study of eligible AIS patients treated with rt-PA at a tertiary comprehensive stroke center from January 2018 to December 2022. Backward stepwise multivariable logistic regression provided the final model. The point score was generated from β-coefficients. The area under the curve (AUC) of the receiver operating characteristics (ROC) and the Hosmer-Lemeshow goodness-of-fit test were used to assess the discrimination and calibration of the model. The conditional probabilities were derived based on the Bayes theorem.Results: Of the included patients, sICH occurred in 26 (3.97%) of the 655. The EGAN score consisted of an early infarct sign (10 points), baseline glucose ≥200 mg/dL (11 points), atrial fibrillation (AF) (13 points), and an NIH Stroke Scale (NIHSS) score ≥10 (12 points). With a cut-off point of 13, the EGAN score demonstrated good discrimination (0.7453 [95% CI: 0.649-0.841]), sensitivity (80.77%), and specificity (58.19%), respectively, for identifying sICH.Conclusions: This easy-to-use scoring model, based on predictors quickly obtained in clinical practices, offers a simple approach to screening for post-thrombolysis sICH and can serve as an alternative option in hospitals with limited resources for thrombolysis therapy.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"647-657"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SPP1 is associated with glioma malignancy and immunosuppressive regulation in 916 samples. 在916个样本中，SPP1与胶质瘤恶性和免疫抑制调节有关。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-04-24 DOI: 10.1080/01616412.2025.2497471

Tong Wang, Jialei Zhou, Gang Chen, Xiang Xu, Haitao Shen

{"title":"SPP1 is associated with glioma malignancy and immunosuppressive regulation in 916 samples.","authors":"Tong Wang, Jialei Zhou, Gang Chen, Xiang Xu, Haitao Shen","doi":"10.1080/01616412.2025.2497471","DOIUrl":"10.1080/01616412.2025.2497471","url":null,"abstract":"Background: Glioma is a disease typically characterized by immunosuppression, which explains its poor prognosis. Therefore, it is urgent to elucidate new molecular mechanisms of immune-supervised escape to improve the efficacy of immunotherapy. Recent studies have identified secreted phosphoprotein 1(SPP1) as a pro-inflammatory and chemokine in macrophages that mediates crosstalk between the innate immune system and tumor cells. We aimed to detect the role of SPP1 in immunomodulation in glioma.Methods: We enrolled 916 patients from different ethnic groups, including 603 patients from The Cancer Genome Atlas (TCGA) database and 313 patients from the Chinese Glioma Genome Atlas (CGGA) database. We performed enrichment analysis and used GSVA to calculate the immune pathway and immune cell infiltration scores of SPP1.In addition, we investigated the correlation between SPP1 and immune checkpoint genes as well as inflammation-related genes.Results: The expression of SPP1 is significantly elevated in IDH wild-type gliomas and high-grade gliomas, particularly in the mesenchymal subtype, and it serves as an independent prognostic factor for overall survival (OS) in glioma patients. SPP1 influences macrophage activation, cytokine secretion, and polarization and exhibits a strong association with various lymphocytes, including T, B and NK cells. Furthermore, SPP1 is strongly correlated not only with immune checkpoint genes but also with various inflammation-related genes.Conclusion: In conclusion, SPP1 expression is tightly linked to the molecular pathology of gliomas and is highly correlated with immune checkpoints. It contributes to glioma immune evasion, positioning SPP1 as a promising new target for immunotherapy in glioma.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"666-676"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral cannabinoid formulation elevates sensory nerve conduction velocity and mitigates oxidative stress to alleviate neuropathic pain in rats. 口服大麻素制剂提高感觉神经传导速度，减轻氧化应激，以减轻大鼠神经性疼痛。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-07 DOI: 10.1080/01616412.2025.2500112

Shruti Mathur, Kamini, Neetu Gupta, Anil G Bhansali, Rajani Mathur, Suman Kundu

{"title":"Oral cannabinoid formulation elevates sensory nerve conduction velocity and mitigates oxidative stress to alleviate neuropathic pain in rats.","authors":"Shruti Mathur, Kamini, Neetu Gupta, Anil G Bhansali, Rajani Mathur, Suman Kundu","doi":"10.1080/01616412.2025.2500112","DOIUrl":"10.1080/01616412.2025.2500112","url":null,"abstract":"Background and aim: Use of potent painkillers like opiates are limited by their abuse potential and adverse physiological effects necessitating new therapeutics for pain management. This study assessed the efficacy of oral cannabinoid formulations (F1-F4) in alleviating chronic neuropathic pain (CP) and investigated their mechanisms through thermal algesia, inflammatory and oxidative stress biomarkers, and sensory nerve conduction velocity (SNCV).Experimental procedures: A 21-day rat model of chronic constriction injury (CCI) of the sciatic nerve was used to evaluate the effects of oral cannabinoid formulations (F1: 500 mg, F2: 1000 mg, F3: 2000 mg, F4: 3000 mg) in MCT oil, with pregabalin as the reference. Male Wistar rats (35) were divided equally into seven groups, with all except the Sham group undergoing sciatic nerve ligation and receiving different formulations.On day 22, behavioral (hot plate, tail flick) and electrophysiological (sensory nerve conduction velocity, SNCV) assessments were performed. SNCV was also measured in the presence of CB1 and CB2 receptor antagonists. Additionally, blood-based markers of inflammation (TNF-α) and oxidative stress (MDA, GSH and CAT) were analysed.Results and conclusions: The vehicle group exhibited significant hyperalgesia (p <0.005), reduced sensory nerve conduction velocity (SNCV) (p <0.005) and elevated MDA and TNF-α levels, along with decreased GSH and CAT levels in both serum and sciatic nerve tissue.Among the formulations, F2 significantly improved pain latency and SNCV (p <0.005) compared to the vehicle group and outperformed F1, F3, F4 and pregabalin (p <0.05). Its effects were mediated through CB1 and CB2 receptor agonism while simultaneously reducing oxidative stress and inflammation, highlighting its potential as a promising candidate for neuropathic pain management.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"745-755"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0