Neurological Research最新文献

{"title":"Effect and mechanism of lateralization of cerebellar-cerebral network abnormalities on language in patients with unilateral temporal lobe epilepsy.","authors":"Linlin Pang, Binglin Fan, Zirong Chen, Zexiang Chen, Xiaomin Pang, Zhao Zhang, Cai Zhong, Jinou Zheng","doi":"10.1080/01616412.2026.2666560","DOIUrl":"https://doi.org/10.1080/01616412.2026.2666560","url":null,"abstract":"<p><strong>Objective: </strong>Since epilepsy is associated with cerebral dysfunction, there may be a recombination of language circuits in the course of epilepsy. We explored the differences in speech impairment patterns in patients with temporal lobe epilepsy (TLE) and different hemiencephalic attacks from the perspective of the cerebellum.</p><p><strong>Methods: </strong>Fifty-eight patients with TLE and 30 healthy controls (HCs) were recruited. including 28 patients with left temporal lobe epilepsy (LTLE) and 30 patients with right temporal lobe epilepsy (RTLE). The resting state functional connection method was used to investigate the effects of lateralization and cerebellar laterality on language function in patients with TLE. The differences in functional connectivity (FC) in the whole cerebellar cortex were compared between the three groups.</p><p><strong>Results: </strong>FC analysis revealed significant differences among the LTLE, RTLE, and HCs. Post-hoc comparisons indicated that both LTLE and RTLE patients exhibited significantly reduced FC relative to HCs. Moreover, the RTLE group demonstrated significantly lower FC compared to the LTLE group.</p><p><strong>Conclusion: </strong>In the brain regions related to language, patients with RTLE had stronger left hemispheric activation than patients with LTLE. The RTLE group had greater language central connection disorder than the HCs. Cerebellar-cerebral functional connectivity has different connectivity patterns between LTLE and RTLE groups. Cerebellar network alterations in TLE may be associated with functional reorganization and a potential shift of language-related network activity toward homologous regions in the contralateral hemisphere.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics-enhanced machine learning for differentiating epidural and subdural hematomas on non-contrast CT.","authors":"Shakiba Houshi, Mehdi Karami, Awat Feizi, Omid Mirmosayyeb, Vahid Shaygannejad","doi":"10.1080/01616412.2026.2666881","DOIUrl":"https://doi.org/10.1080/01616412.2026.2666881","url":null,"abstract":"<p><strong>Background: </strong>Differentiating epidural hematoma (EDH) from subdural hematoma (SDH) on non-contrast CT (NCCT) is clinically important but can be challenging when imaging features overlap. This study evaluated whether radiomic features combined with machine learning could improve discrimination between EDH and SDH.</p><p><strong>Methods: </strong>In this retrospective study, 175 adults with surgically confirmed EDH or SDH were analyzed. Conventional morphometric CT features and 107 radiomic features extracted from manually segmented hematomas were assessed. After LASSO-based feature selection, machine learning models were developed and evaluated using area under the receiver operating characteristic curve (AUC), area under the precision-recall curve (AUCPR), and accuracy.</p><p><strong>Results: </strong>Radiomic features showed slightly better discriminative performance than handcrafted morphometric features alone. Among the evaluated models, XGBoost achieved the best overall performance. The highest performance was obtained using the combined feature set of radiomic and morphometric variables, with an AUC of 0.75, an AUCPR of 0.70, and an accuracy of 0.74.</p><p><strong>Conclusions: </strong>Integrating radiomic and conventional morphometric CT features improves automated differentiation of EDH and SDH. Radiomics-assisted machine learning may serve as a useful decision-support tool in diagnostically challenging cases, although further external validation is needed before clinical implementation.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation of serum uric acid and glycosylated hemoglobin levels with mild cognitive impairment in older patients with comorbid type 2 diabetes mellitus and hypertension.","authors":"Mei Li","doi":"10.1080/01616412.2026.2650444","DOIUrl":"https://doi.org/10.1080/01616412.2026.2650444","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the correlations of serum uric acid (SUA) and glycated hemoglobin (HbA1c) levels with mild cognitive impairment (MCI) in patients with comorbid type 2 diabetes mellitus (T2DM) and hypertension, and to further identify potential risk factors associated with MCI.</p><p><strong>Methods: </strong>In this retrospective study, 126 older patients with T2DM and hypertension were divided into a normal cognition group (<i>n</i> = 74) and an MCI group (<i>n</i> = 52) based on Mini-Mental State Examination (MMSE) scores. The correlations of SUA and HbA1c with MMSE scores, their predictive value for MCI, their relationships with clinical variables, and independent risk factors for MCI were evaluated using Spearman correlation, receiver operating characteristic curve, and logistic regression analyses.</p><p><strong>Results: </strong>In the MCI group, SUA and HbA1c levels were significantly negatively correlated with MMSE scores (<i>r</i> = -0.419 and -0.510). For predicting MCI, the area under the ROC curve (AUC) was 0.742 for SUA (sensitivity: 78.85%, specificity: 62.16%, cut-off value: 319.31), 0.781 for HbA1c (sensitivity: 48.08%, specificity: 94.59%, cut-off value: 8.94), and 0.851 for their combination (sensitivity: 73.08%, specificity: 85.14%, cut-off value: 0.42). Elevated SUA and HbA1c levels and older age were independent risk factors for MCI, whereas higher IBIL and HDL-C levels and reading habits were protective factors.</p><p><strong>Conclusions: </strong>SUA and HbA1c levels were elevated in older patients with T2DM and hypertension who developed MCI. These markers were identified as independent risk factors for MCI in patients with T2DM-hypertension, aiding in the prediction of MCI occurrence in these patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral hemorrhage in brain metastases: a correlation with imaging characteristics and vasogenic edema.","authors":"Büşra Türkkahraman, Ezel Yaltirik Bilgin, Özkan Unal","doi":"10.1080/01616412.2026.2667504","DOIUrl":"https://doi.org/10.1080/01616412.2026.2667504","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the relationship between intratumoral hemorrhage detected on brain magnetic resonance imaging (MRI) and patients' demographic characteristics, primary tumor type/subtype, radiological features of metastases, and potential impact on survival. Our institution's Non-Interventional Research Ethics Committee approved this study.</p><p><strong>Methods: </strong>Two hundred twenty-five patients diagnosed with brain metastases based on contrast-enhanced MRI were analyzed retrospectively between August 2017 and June 2023. Demographic data, primary malignancy type/subtype, imaging characteristics, and survival outcomes were recorded. Intratumoral hemorrhage was identified as low-signal intensity areas on T2*-weighted gradient echo (T2*-GRE) or susceptibility-weighted imaging (SWI). Patients were classified into hemorrhagic and non-hemorrhagic groups. The groups were compared with respect to age, sex, tumor type/subtype, number, localization, size, peritumoral edema, and edema-to-tumor ratio. In patients with vasogenic edema, the ratio of the largest edema diameter to tumor diameter was calculated to assess its association with hemorrhage.</p><p><strong>Results: </strong>Intratumoral hemorrhage was detected in 90 patients (40%). Hemorrhage prevalence varied by primary cancer: malignant melanoma (75%), renal cell carcinoma (50%), ovarian cancer (50%), lung cancer (35.2%), and breast cancer (28.2%) (χ² = 22.425, <i>p</i> < 0.001). Hemorrhagic lesions demonstrated significantly larger size (Z = -2.569, <i>p</i> < 0.001), greater edema extent (Z = -4.725, <i>p</i> < 0.001), and higher edema/tumor ratios (Z = -2.857, <i>p</i> = 0.004). Hemorrhage was most frequent in triple-negative breast cancer (χ² = 8.383, <i>p</i> = 0.015) and in lung adenocarcinomas (χ² = 5.850, <i>p</i> = 0.016). No statistically significant difference in overall survival was observed between patients with hemorrhagic and non-hemorrhagic metastases (<i>p</i> = 0.352).</p><p><strong>Conclusion: </strong>Intratumoral hemorrhage rates vary across primary tumor types. Its presence correlates with larger lesion size and extensive vasogenic edema, suggesting potential diagnostic and prognostic value in evaluating brain metastases.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty as a prognostic indicator of outcomes after brain tumor surgery: a meta-analysis.","authors":"Mingfeng Zhao, Wenzhu Yang, Zhiguo Han","doi":"10.1080/01616412.2026.2663489","DOIUrl":"https://doi.org/10.1080/01616412.2026.2663489","url":null,"abstract":"<p><strong>Background: </strong>Frailty, a state of diminished physiological reserve, may influence outcomes after brain tumor surgery. This meta-analysis synthesized evidence on the association between preoperative frailty and postoperative outcomes in patients with brain tumors.</p><p><strong>Methods: </strong>We systematically searched Cochrane Library, Embase, Google Scholar, OVID, and PubMed from inception to December 2025. Studies using validated multi-domain frailty instruments in patients undergoing brain tumor surgery were eligible. Two reviewers independently screened studies, extracted data, and assessed risk of bias using QUIPS. Pooled odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs) were calculated using random-effects models. Heterogeneity was quantified using I² and explored through subgroup analyses. GRADE assessed certainty of evidence.</p><p><strong>Results: </strong>Seventeen studies comprising 68,954 patients (19,659 frail, 49,295 nonfrail) were included. Frailty was associated with higher mortality (OR 1.77; 95% CI 1.14-2.76), complications (OR 2.10; 95% CI 1.60-2.76), non-routine discharge (OR 2.09; 95% CI 1.39-3.14), and longer hospital stay (MD 4.60 days; 95% CI 0.64-8.56). No association was found with readmission (OR 1.01; 95% CI 0.80-1.28). Extreme heterogeneity (I² 90-99%) limits interpretability of pooled estimates. Subgroup analyses showed variation in effect sizes, but residual heterogeneity remained unexplained. GRADE certainty was low to very low for all outcomes except readmission (moderate).</p><p><strong>Conclusions: </strong>Frailty is consistently associated with adverse outcomes after brain tumor surgery, but extreme heterogeneity precludes precise quantitative risk prediction. Subgroup analyses attempting to compare slow-growing versus aggressive tumor types predominantly revealed an absence of stratified reporting in the primary literature.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-27"},"PeriodicalIF":1.5,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of levodopa response rate in association with clinical features in Parkinson's disease subjects with and without STN-DBS.","authors":"Halil Onder, Selcuk Comoglu","doi":"10.1080/01616412.2025.2537897","DOIUrl":"10.1080/01616412.2025.2537897","url":null,"abstract":"<p><strong>Background: </strong>The levodopa response (LR) in patients with deep brain stimulation of the subthalamic nucleus (STN-DBS) has rarely been investigated. We sought to investigate the LR, and clinical features associated with STN-DBS therapy.</p><p><strong>Methods: </strong>PD subjects with and without STN-DBS who applied to our movement disorders outpatient clinics between January 2023 and July 2023 were evaluated. The clinical features and detailed clinical scales, including MDS-UPDRS, FOGQ, FES, VHI, and PDQ-39 were administered. LR was measured by calculating the percent medication-'off' to 'on' change in the MDS-UPDRS-3 scores.</p><p><strong>Results: </strong>Overall, 169 patients with PD participated in this study (35 patients with STN-DBS, and 134 patients without STN-DBS). The mean age of the patients was 60.9 ± 8.8 y (F/M = 66/103), and the disease duration was 7y. The comparative analyses revealed that the disease duration, the MDS-UPDRS-2 and MDS-UPDRS-3 'off' scores were higher in the DBS group. In addition, the scores for axial features such as VHI, FOGQ, and FES-I were higher in the DBS group. However, the LR percentage did not differ between groups (0.47 versus 0.44, <i>p</i> = 0.095). The regression analyses revealed LR rate (B = 5.547, <i>p</i> < 0.01), disease duration (B = 0.349, <i>p</i> < 0.001), and FOGQ (B = 0.175, <i>p</i> < 0.01) as predictors of STN-DBS group.</p><p><strong>Conclusions: </strong>LR was similar between patients with and without STN-DBS, suggesting that non-dopaminergic mechanisms contribute to the efficacy of STN-DBS while underscoring the continued importance of dopaminergic therapy in these patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"576-585"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPEDITION: an Exploratory deep learning method to quantitatively predict hematoma progression after intracerebral hemorrhage.","authors":"Siqi Chen, Zixiao Li, Yinsheng Li, Donghua Mi","doi":"10.1080/01616412.2025.2536668","DOIUrl":"10.1080/01616412.2025.2536668","url":null,"abstract":"<p><strong>Objects: </strong>This study aims to develop an Exploratory deep learning method to quantitatively predict hematoma progression (EXPEDITION in short) after intracerebral hemorrhage (ICH).</p><p><strong>Methods: </strong>Patients with primary ICH in the basal ganglia or thalamus were retrospectively enrolled, and their baseline non-contrast CT (NCCT) image, CT perfusion (CTP) images, and subsequent re-examining NCCT images from the 2nd to the 8th day after baseline CTP were collected. The subjects who had received three or more re-examining scans were categorized into the test data set, and others were assigned to the training data set. Hematoma volume was estimated by manually outlining the lesion shown on each NCCT scan. Cerebral venous hemodynamic feature was extracted from CTP images. Then, EXPEDITION was trained. The Bland-Altman analysis was used to assess the prediction performance.</p><p><strong>Results: </strong>A total of 126 patients were enrolled initially, and 73 patients were included in the final analysis. They were then categorized into the training data set (58 patients with 93 scans) and the test data set (15 patients with 50 scans). For the test set, the mean difference [mean ±1.96SD] of hematoma volume between the EXPEDITION prediction and the reference is -0.96 [-9.64, +7.71] mL. Specifically, in the test set, the consistency between the true and the predicted volume values was compared, indicating that the EXPEDITION achieved the needed accuracy for quantitative prediction of hematoma progression.</p><p><strong>Conclusions: </strong>An Exploratory deep learning method, EXPEDITION, was proposed to quantitatively predict hematoma progression after primary ICH in basal ganglia or thalamus.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"545-554"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue and its contributing factors in people with multiple sclerosis: a cross-sectional study.","authors":"Ida Mohammadi, Saeed Vaheb, Shahryar Rajai Firouzabadi, Mohammad Yazdan Panah, Vahid Shaygannejad, Omid Mirmosayyeb","doi":"10.1080/01616412.2025.2537328","DOIUrl":"10.1080/01616412.2025.2537328","url":null,"abstract":"<p><strong>Background: </strong>Fatigue is a common and debilitating symptom in people with multiple sclerosis (PwMS), yet its contributing factors are not fully understood. This study examined how fatigue severity relates to physical activity, limb function, mood, and demographics within a unified framework.</p><p><strong>Methods: </strong>In this cross-sectional study, PwMS were recruited in Isfahan, Iran, from April 2023 to April 2024. Participants completed the Fatigue Severity Scale, and data were collected on demographics, cognitive processing speed (Symbol Digit Modalities Test), physical activity (IPAQ), upper limb function (9-Hole Peg Test), lower limb function (Timed 25-Foot Walk), depression, and anxiety (Beck inventories). Associations between fatigue severity and these factors were analyzed using stepwise linear and logistic regression models.</p><p><strong>Results: </strong>Among 141 participants (90.1% female; mean age: 37.87 ± 9.74 years), fatigue prevalence was 61.7%. Higher fatigue severity was significantly associated with greater depression (B (95% CI) = 0.47 (0.32, 0.63), β = 0.481), poorer lower limb function (B (95% CI) = 1.82 (0.48, 3.16), β = 0.234), progressive MS (B (95% CI) = 7.38 (1.85, 12.91), β = 0.186), and lower physical activity (B (95% CI) = -0.0006 (-0.001, -0.0001), β = -0.156). Logistic regression indicated that being married (OR (95% CI) = 3.06 (1.20, 7.80), worse lower limb function (OR (95% CI) = 1.55 (1.01, 2.37), and higher depression scores (OR (95% CI) = 1.06 (1.01, 1.10) were associated with increased odds of clinically significant fatigue.</p><p><strong>Conclusion: </strong>Fatigue was common among PwMS and was independently associated with depression, reduced lower extremity function, progressive MS, lower physical activity, and marital status. These findings highlight key physical and psychological factors associated with fatigue; however, longitudinal studies are needed to establish causality.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"555-567"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>FAM111B</i> as a biomarker influences the prognosis and immune microenvironment of low-grade gliomas.","authors":"Shuang Chen, Zhendong Liu, Yanzheng Gao","doi":"10.1080/01616412.2025.2538129","DOIUrl":"10.1080/01616412.2025.2538129","url":null,"abstract":"<p><strong>Background: </strong>In recent years, FAM111B has been found to be closely related to the occurrence and development of various cancers. However, the role of FAM111B in low-grade glioma (LGG) remains unclear.</p><p><strong>Objective: </strong>This study aims to investigate the regulatory role of FAM111B in the progression of LGG.</p><p><strong>Method: </strong>First, this study explored the expression levels of FAM111B in LGG using various databases. Second, Wilcoxon and Kruskal-Wallis tests were employed to assess the association between FAM111B expression and clinical characteristics. Survival analysis and multivariate Cox regression evaluated the prognostic value of FAM111B expression levels in LGG. Additionally, GSEA was performed to explore pathways associated with FAM111B expression, while Pearson correlation analysis revealed relationships between FAM111B expression and tumor-associated macrophages as well as immune checkpoints.</p><p><strong>Results: </strong>The findings of this study demonstrate that high expression of FAM111B is significantly associated with molecular characteristics of LGG. FAM111B serves as an independent prognostic factor, and the high expression of FAM111B significantly shortens survival of LGG patients. The methylation site cg14859464 was found to negatively regulate FAM111B expression. FAM111B primarily activates pathways related to Cell cycle regulation, DNA replication, and Mismatch repair. Additionally, FAM111B expression showed positive correlations with macrophage marker CD163 and immune checkpoint molecule CD276.</p><p><strong>Conclusion: </strong>This study conducted an in-depth investigation into the biological functions of FAM111B in LGG. We identified FAM111B as an independent prognostic factor associated with unfavorable clinical outcomes in LGG. The findings provide novel insights and actionable targets for the precise diagnosis and effective management of LGG.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"602-619"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of bundle-based preventive care on healthcare-associated infection control in neurosurgical patients.","authors":"Xiaowei Xu, Liqin Wei, Weiwei Wang, Yu Sun, Li Zheng, Yan Wang","doi":"10.1080/01616412.2025.2537329","DOIUrl":"10.1080/01616412.2025.2537329","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the effects of bundle-based preventive care on the control of healthcare-associated infections (HAIs) in patients undergoing neurosurgical procedures.</p><p><strong>Methods: </strong>One hundred and twenty patients who underwent neurosurgery were enrolled and randomly assigned, using a random number table method, to either the control group (<i>n</i> = 60), which received routine nursing care, or the observation group (<i>n</i> = 60), which bundle-based preventive care. The incidence of HAIs, antibiotic usage, and pathogen detection rates were compared between the two groups. In addition, adverse events and length of hospital stay were recorded. Nursing quality and patient satisfaction were also evaluated.</p><p><strong>Results: </strong>The observation group showed significantly better outcomes than the control group. Specifically, its HAI rate (6.67% vs. 21.67%) and total pathogen detection rate (6.67% vs. 20.00%) were significantly lower (<i>p</i> < 0.05). The use of dual and triple antibiotic regimens was also reduced (<i>p</i> < 0.05). Moreover, the observation group experienced fewer adverse events and a shorter hospital stay (<i>p</i> < 0.05). Nursing quality scores - including hand hygiene, disinfection and isolation, nursing communication, and documentation - were all higher in the observation group (<i>p</i> < 0.05). Patient satisfaction was significantly improved as well (95.00% vs. 83.33%, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Bundle-based preventive care can effectively reduce postoperative HAIs and antibiotic usage in neurosurgical patients, lower the incidence of adverse events, and significantly improve nursing quality and patient satisfaction.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"568-575"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}