Neurological Research最新文献

Long-segment posterior spinal instrumentation with intracanal bone fragment compaction for indirect anterior column support: a single-arm feasibility study in high load-sharing classification score thoracolumbar burst fractures. 长段后路椎管内固定骨碎片压实用于间接前柱支撑：高负荷分担分级评分胸腰椎爆裂骨折单臂可行性研究。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-19 DOI: 10.1080/01616412.2026.2752410

Seyed Reza Bagheri, Jin Sung Kim, Kian Zohrabi, Mohammadali Ataee, Negin Mesbahi, Ehsan Alimohammadi

{"title":"Long-segment posterior spinal instrumentation with intracanal bone fragment compaction for indirect anterior column support: a single-arm feasibility study in high load-sharing classification score thoracolumbar burst fractures.","authors":"Seyed Reza Bagheri, Jin Sung Kim, Kian Zohrabi, Mohammadali Ataee, Negin Mesbahi, Ehsan Alimohammadi","doi":"10.1080/01616412.2026.2752410","DOIUrl":"https://doi.org/10.1080/01616412.2026.2752410","url":null,"abstract":"Background: Thoracolumbar burst fractures with high Load Sharing Classification (LSC) scores are mechanically unstable and associated with severe vertebral comminution and failure risk after short-segment fixation. This study evaluated outcomes of long-segment posterior fixation combined with intracanal bone fragment compaction as an indirect means of supporting the anterior column.Methods: This retrospective study analyzed prospectively collected data from 121 consecutive patients with unstable thoracolumbar burst fractures (T10-L2) and LSC scores >6. All patients underwent open long-segment posterior instrumentation, decompression, and compaction of retropulsed intracanal bone fragments. Radiological outcomes included Cobb angle, percentage of anterior height compression (PAHC), vertebral body compression ratio (VBCR), and spinal canal compromise. Neurological recovery was assessed using the American Spinal Injury Association (ASIA) scale, and functional outcomes using the Oswestry Disability Index (ODI).Results: The cohort included 70 men and 51 women, with a mean age of 37.2 years and follow-up of 23.2 months. At final follow-up, 58.7% (95% CI 49.8-67.1%) achieved ASIA grade E. Significant improvements were observed in VBCR, PAHC, Cobb angle (15.6° to 7.9°; p = 0.008), and spinal canal compromise (65.2% to 8.7%; p < 0.001). Mean ODI improved from 59.4 to 8.4 (p < 0.001).Conclusion: Long-segment posterior fixation with intracanal bone fragment compaction was associated with favorable short- to mid-term neurological, functional, and radiological outcomes. Prospective comparative studies with CT-based fusion assessment, standardized safety reporting, and longer follow-up are required to confirm effectiveness and durability.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putative predictive power of baseline cerebrospinal fluid dipeptidyl peptidase-4 on the conversion to secondary progressive multiple sclerosis. 基线脑脊液二肽基肽酶-4对继发性进行性多发性硬化症转化的推测预测能力。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-18 DOI: 10.1080/01616412.2026.2746401

Nuray Sancar, Sefa Özaydın, Ahmed Serkan Emekli, Vuslat Yılmaz, Recai Türkoğlu, Erdem Tüzün

{"title":"Putative predictive power of baseline cerebrospinal fluid dipeptidyl peptidase-4 on the conversion to secondary progressive multiple sclerosis.","authors":"Nuray Sancar, Sefa Özaydın, Ahmed Serkan Emekli, Vuslat Yılmaz, Recai Türkoğlu, Erdem Tüzün","doi":"10.1080/01616412.2026.2746401","DOIUrl":"https://doi.org/10.1080/01616412.2026.2746401","url":null,"abstract":"Background: Dipeptidyl peptidase-4 (DPP4) has many inflammation-related functions such as T cell activation, and complement activation and is recognized as a putative pathogenic factor in multiple sclerosis (MS). Our aim was to analyze whether baseline cerebrospinal fluid (CSF) levels of DPP4 and DPP4-induced complement breakdown byproducts might predict MS progression.Methods: Levels of DPP4, factor C3a (C3a), factor C4a (C4a), factor Ba (Ba) and soluble membrane attack complex (sMAC) were measured by ELISA in CSF obtained during the first clinical attack of 80 MS patients. The association between CSF markers and disability progression was assessed by regression analyses.Results: Fourteen of 80 patients had converted to secondary progressive MS (SPMS) in a follow-up period of 9.4 ± 5.1 years. As compared to patients preserving relapsing-remitting MS (RRMS) status, SPMS-convertors showed significantly higher baseline CSF DPP4 (p = 0.035) and Ba (p = 0.013) levels. Receiver operating characteristic analysis indicated baseline CSF DPP4 level to be associated with increased risk of SPMS conversion (p = 0.026, AUC = 0.691, 95% CI = 0.6-0.8). Cox regression analysis showed that after adjustment for onset age and duration of disease, DPP4 levels were associated with increased risk for conversion to SPMS (p = 0.040), and baseline CSF Ba levels were associated with time to disability progression (EDSS 3.0) (p = 0.031).Conclusions: Baseline CSF DPP4 levels may predict the emergence of SPMS at the early stage of disease, whereas baseline Ba levels appear to be associated with earlier progression of MS.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive-age status and intracranial hypertension in women with cerebral venous thrombosis: a retrospective cohort study. 脑静脉血栓形成女性的生育年龄和颅内高压：一项回顾性队列研究。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-16 DOI: 10.1080/01616412.2026.2743168

Lu Liu, Chunxiao Lu, Ran Duan, Zilin Xu, Hui Li, Xiaoming Zhang, Yifan Zhou, Weiyue Zhang, Huimin Jiang, Xunming Ji, Chen Zhou

{"title":"Reproductive-age status and intracranial hypertension in women with cerebral venous thrombosis: a retrospective cohort study.","authors":"Lu Liu, Chunxiao Lu, Ran Duan, Zilin Xu, Hui Li, Xiaoming Zhang, Yifan Zhou, Weiyue Zhang, Huimin Jiang, Xunming Ji, Chen Zhou","doi":"10.1080/01616412.2026.2743168","DOIUrl":"https://doi.org/10.1080/01616412.2026.2743168","url":null,"abstract":"Background: Cerebral venous thrombosis (CVT) predominantly affects reproductive-age women, but the relationship between reproductive-age status and intracranial hypertension (IH) phenotype remains unclear.Methods: We performed a retrospective cohort study of consecutive female patients with first-ever acute or subacute CVT treated at a tertiary stroke center between September 2014 and March 2023. Patients were stratified into reproductive-age (18-45 years) and non-reproductive-age (>45 years) groups. Clinical characteristics, imaging findings, and 12-month outcomes were compared between groups.Results: A total of 182 women with CVT were included, comprising 122 of reproductive age. Reproductive-age women were more likely to present with IH at admission compared with their non-reproductive-age counterparts (59.0% vs. 41.7%, p = 0.027). In the overall female cohort, reproductive-age status (adjusted odds ratio [aOR], 1.96; 95% confidence interval [CI], 1.00-3.84; p = 0.049) and superior sagittal sinus involvement (aOR, 2.73; 95% CI, 1.36-5.48; p = 0.005) were independently associated with IH. Within the reproductive-age subgroup, superior sagittal sinus involvement (aOR, 3.00; 95% CI, 1.25-7.21; p = 0.014) and left lateral sinus system involvement (aOR, 3.21; 95% CI, 1.37-7.56; p = 0.007) were independently associated with IH. Although overall functional outcomes at follow-up were similar, residual visual impairment was significantly more frequent in reproductive-age women with IH.Conclusions: Among women with CVT, reproductive-age status is associated with a greater likelihood of IH. In reproductive-age women, superior sagittal sinus and left lateral sinus system involvement were independently associated with IH, although the laterality-specific finding requires further validation.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endovascular treatment of symptomatic intracranial atherosclerotic stenosis: preliminary findings from a single-center clinical series of angioplasty and stenting using the Coyote balloon catheter. 症状性颅内动脉粥样硬化性狭窄的血管内治疗：使用Coyote球囊导管进行血管成形术和支架植入的单中心临床系列研究的初步结果。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-15 DOI: 10.1080/01616412.2026.2747745

Bekir Turgut, Battal Tuğberk Altındal, Halil İbrahim Şara, Mehmet Kenan, Mustafa Altaş, Funda Gök, Osman Koç

{"title":"Endovascular treatment of symptomatic intracranial atherosclerotic stenosis: preliminary findings from a single-center clinical series of angioplasty and stenting using the Coyote balloon catheter.","authors":"Bekir Turgut, Battal Tuğberk Altındal, Halil İbrahim Şara, Mehmet Kenan, Mustafa Altaş, Funda Gök, Osman Koç","doi":"10.1080/01616412.2026.2747745","DOIUrl":"https://doi.org/10.1080/01616412.2026.2747745","url":null,"abstract":"Objectives: Data on the clinical efficacy and safety of the Coyote balloon catheter for symptomatic intracranial atherosclerotic stenosis (sICAS) are lacking. This study reports preliminary findings from the first clinical series evaluating this device, with the aim of describing procedural outcomes and 6-month restenosis rates.Methods: This retrospective study included 32 patients (39 lesions) who underwent elective endovascular treatment for sICAS at the Interventional Radiology unit of our institution between July 2024 and December 2025. The primary endpoints were acute technical success (successful device delivery, residual stenosis < 50%, and TICI 2b/3 flow) and 30-day procedural success (technical success without 30-day stroke or death). Secondary endpoints included 6-month restenosis and 1-year target-vessel stroke.Results: The stroke rate during the first month was 5.1% per procedure (6.3% per patient). At 6-month follow-up, restenosis was observed in 7.9% of lesions. Technical success was achieved in 100% of lesions, with all cases obtaining TICI 2b/3 distal perfusion. The mean degree of stenosis significantly decreased from 88.08% preoperatively to 30.12% postoperatively (p < 0.001). The perioperative complication rate was 2.6%. The 30-day procedural success rate was 94.9%, as minor periprocedural strokes occurred in 2 cases (5.1%).Discussion: This clinical series demonstrates that the Coyote balloon catheter is technically feasible in sICAS with a favorable safety profile. The observed restenosis and stroke rates indicate a viable option for intracranial angioplasty, providing descriptive data for future prospective investigations.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of repetitive transcranial magnetic stimulation on global cognitive performance and activities of daily living in post-stroke patients: a systematic review and meta-analysis. 重复经颅磁刺激对脑卒中后患者整体认知表现和日常生活活动的影响：系统回顾和荟萃分析

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-14 DOI: 10.1080/01616412.2026.2740658

Mingchen Wang, Guan Wang

{"title":"Effects of repetitive transcranial magnetic stimulation on global cognitive performance and activities of daily living in post-stroke patients: a systematic review and meta-analysis.","authors":"Mingchen Wang, Guan Wang","doi":"10.1080/01616412.2026.2740658","DOIUrl":"https://doi.org/10.1080/01616412.2026.2740658","url":null,"abstract":"Background: Post-stroke cognitive impairment (PSCI) severely affects patients' daily living and independence, with limited treatment options. Repetitive transcranial magnetic stimulation (rTMS) shows promise but inconsistencies in reported effect sizes across cognitive domains.Methods: We systematically searched PubMed, Web of Science, Cochrane Library, and EMBASE up to March 2026 for randomized controlled trials evaluating rTMS combined with rehabilitation versus sham or rehabilitation alone in stroke patients. Outcomes included MMSE, MoCA, Digit Span Test (DST), and modified Barthel Index (MBI). Meta-analysis was performed using RevMan 5.4.Results: Ten RCTs involving 666 patients were included. rTMS significantly improved MMSE (MD = 1.76, 95%CI[1.10, 2.43], p < 0.00001, I2 = 5%) and MoCA scores (MD = 2.64, 95% CI[1.74,3.55], p < 0.00001, I2 = 0%). No significant effect was found on DST-forward (p = 0.13), but DST-backward showed mild improvement (MD = 0.77, 95% CI[0.35,1.18], p = 0.0003, I2 = 62%). MBI scores were significantly enhanced (MD = 10.68, 95% CI[7.91,13.46], p < 0.00001, I2 = 0%).Conclusion: Based on low-to-moderate certainty evidence, rTMS combined with rehabilitation may improve global cognitive screening performance and daily living ability in stroke patients, with a mild benefit on working memory. Further studies are needed to optimize stimulation protocols.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum utrophin levels in patients with myasthenia gravis: an exploratory study. 重症肌无力患者血清肌营养因子水平的探索性研究。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-13 DOI: 10.1080/01616412.2026.2746411

Manato Yasuda, Akiyuki Uzawa, Etsuko Ogaya, Hideo Handa, Kentaro Kurumada, Hiroyuki Akamine, Yukiko Ozawa, Kyosuke Takasaka, Yosuke Onishi, Hiroki Masuda, Masahiro Mori, Satoshi Kuwabara

{"title":"Serum utrophin levels in patients with myasthenia gravis: an exploratory study.","authors":"Manato Yasuda, Akiyuki Uzawa, Etsuko Ogaya, Hideo Handa, Kentaro Kurumada, Hiroyuki Akamine, Yukiko Ozawa, Kyosuke Takasaka, Yosuke Onishi, Hiroki Masuda, Masahiro Mori, Satoshi Kuwabara","doi":"10.1080/01616412.2026.2746411","DOIUrl":"https://doi.org/10.1080/01616412.2026.2746411","url":null,"abstract":"Objectives: The role of utrophin, a protein expressed at neuromuscular junctions, remains unclear in myasthenia gravis (MG). This study aimed to investigate serum utrophin levels in immunotherapy-naïve patients with different MG subtypes and evaluate changes before and after immunotherapy initiation.Methods: We measured serum utrophin levels in immunotherapy-naïve MG patients (n = 39), including acetylcholine receptor (AChR) antibody-positive MG (AChR-MG) (n = 30; ocular type: n = 10, generalized type: n = 20) and muscle-specific tyrosine kinase antibody-positive MG (MuSK-MG) (n = 9; all generalized type) patients and healthy controls (HCs) (n = 21). We analyzed relationships between serum utrophin levels, clinical parameters, and antibody levels. In generalized AChR-MG, serum utrophin levels were measured before and after immunotherapy.Results: Median serum utrophin levels tended to be higher in patients with MG than in HCs (34.0 vs. 13.8 ng/mL; Hodges-Lehmann estimate, 7.04 ng/mL; 95% confidence interval: -0.09-37.3; p = 0.051). In MuSK-MG, an exploratory positive correlation with the MG Foundation of America (MGFA) classification was observed (ρ = 0.69, nominal p = 0.041). In generalized AChR-MG, median concentrations numerically decreased from 43.8 to 20.2 ng/mL after immunotherapy (p = 0.064), but no significant change was observed in the 15 patients whose paired samples were both within the standard range (p = 0.80).Discussion: These exploratory findings suggest that circulating utrophin may reflect disease-related biological changes in MG, although definitive conclusions regarding its biomarker utility cannot be drawn. Further validation in larger cohorts using analytically validated assays is warranted.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Predictors of futile recanalization following mechanical thrombectomy in acute ischemic stroke: a single-center retrospective cohort study. 撤回声明：急性缺血性卒中机械取栓后无效再通的预测因素：一项单中心回顾性队列研究。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-11 DOI: 10.1080/01616412.2026.2739202

引用次数: 0

Clinical outcomes after intravenous thrombolysis for acute ischemic stroke in low- and middle-income countries: a pooled analysis of 67,917 patients and systematic review. 低收入和中等收入国家急性缺血性卒中静脉溶栓治疗的临床结果：67,917例患者的汇总分析和系统评价

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-11 DOI: 10.1080/01616412.2026.2743171

Meiling Carbajal-Galarza, Nathaly Olga Chinchihualpa-Paredes, Irving Calisaya-Madariaga, Fritz Vascones, Nestor Flores-Rodríguez, Sandra Berrú-Villalobos, Niels Pacheco-Barrios, Daniel Vera, Sergio Abanto-Perez, Miriam Guerrero, Karlos Acurio, Carlos Abanto

{"title":"Clinical outcomes after intravenous thrombolysis for acute ischemic stroke in low- and middle-income countries: a pooled analysis of 67,917 patients and systematic review.","authors":"Meiling Carbajal-Galarza, Nathaly Olga Chinchihualpa-Paredes, Irving Calisaya-Madariaga, Fritz Vascones, Nestor Flores-Rodríguez, Sandra Berrú-Villalobos, Niels Pacheco-Barrios, Daniel Vera, Sergio Abanto-Perez, Miriam Guerrero, Karlos Acurio, Carlos Abanto","doi":"10.1080/01616412.2026.2743171","DOIUrl":"https://doi.org/10.1080/01616412.2026.2743171","url":null,"abstract":"Introduction: Stroke is a leading cause of disability and mortality worldwide. Patients in low- and middle-income countries (LMICs) are disproportionately affected, yet thrombolysis outcomes in these settings are underexplored.Methods: We searched PubMed, Embase, Scopus, Web of Science, and Global Index Medicus through April 2024. Outcomes were 90-day functional independence (mRS 0-2), symptomatic intracerebral hemorrhage (sICH), and 90-day mortality. Risk of bias used Cochrane RoB 2 and ROBINS-I; random-effects meta-analyses estimated pooled proportions with I2.Results: Of 1,865 records screened, 79 studies (67,917 patients; 24 countries) were included. Most used alteplase; others examined tenecteplase, recombinant prourokinase, or reteplase; eight compared low- vs standard-dose alteplase. Pooled estimates were functional independence 63% (95% CI, 58-67), sICH 4% (95% CI, 3-5), and mortality 8% (95% CI, 6-10). Functional independence was similar across continents; sICH was lowest in Asia, mortality lowest in Africa. Heterogeneity was high, partly explained by baseline stroke severity and study size. Overall risk of bias was low to moderate.Conclusions: Standard-dose thrombolysis within 4.5 hours in LMICs shows efficacy and safety comparable to reports from high-income countries, with regional variation in safety and mortality. These results support broader implementation of thrombolysis in resource-limited settings to reduce global stroke disparities.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombectomy for distal medium vessel occlusion: a comprehensive meta-analysis of randomized controlled trials. 远端中血管闭塞取栓：一项随机对照试验的综合meta分析。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-07 DOI: 10.1080/01616412.2026.2745027

Omar Fayez Abbas, Aya Magdy Siam, Roaa Haddad, Fatma Aljalawy, Abdullah Almarfadi, Nour Aldin Tarek Ahmed, Ahmad Odeh, Ahmed Harb, Abdelrahman M Hamouda, Ram Saha, Sherief Ghozy, Adam A Dmytriw

{"title":"Thrombectomy for distal medium vessel occlusion: a comprehensive meta-analysis of randomized controlled trials.","authors":"Omar Fayez Abbas, Aya Magdy Siam, Roaa Haddad, Fatma Aljalawy, Abdullah Almarfadi, Nour Aldin Tarek Ahmed, Ahmad Odeh, Ahmed Harb, Abdelrahman M Hamouda, Ram Saha, Sherief Ghozy, Adam A Dmytriw","doi":"10.1080/01616412.2026.2745027","DOIUrl":"https://doi.org/10.1080/01616412.2026.2745027","url":null,"abstract":"Background: Distal medium vessel occlusion (DMVO) accounts for a substantial proportion of acute ischemic strokes, yet the role of endovascular therapy (EVT) in this population remains uncertain.Methods: PubMed, Scopus, Web of Science, and the Cochrane Library were systematically searched from inception through May 2026. Randomized and comparative studies evaluating EVT versus non-EVT strategies in acute ischemic stroke due to DMVO were included. Primary outcomes were excellent functional outcome (90-day modified Rankin Scale [mRS] 0-1), functional independence (mRS 0-2), symptomatic intracranial hemorrhage (sICH), and 90-day mortality. Pooled risk ratios (RRs) and risk differences were calculated using random-effects models.Results: Six randomized controlled trials involving 2,061 patients were included. EVT did not significantly improve excellent functional outcome (mRS 0-1) (RR, 1.19; 95% CI, 0.89-1.59), functional independence (RR, 1.07; 95% CI, 0.89-1.30), independent ambulation (RR, 0.97; 95% CI, 0.86-1.09), overall survival (RR, 0.97; 95% CI, 0.91-1.04), or reduce death or severe dependency (RR, 1.07; 95% CI, 0.76-1.50). Ninety-day mortality was also similar between groups (RR, 1.12; 95% CI, 0.73-1.71). Although sICH occurred more frequently with EVT, the difference did not reach statistical significance (RR, 2.31; 95% CI, 0.98-5.46; p = .054); however, this estimate was sensitive to the exclusion of a single study.Conclusions: EVT was not associated with improved functional or survival outcomes in unselected patients with DMVO. Although sICH appeared more frequently with EVT, the difference was not statistically significant. Current evidence does not support routine EVT in unselected DMVO.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The silent pandemic: the overlooked toll of stroke compared to COVID-19. 无声的大流行：与COVID-19相比，中风的死亡人数被忽视。

IF 1.9 4区医学

Neurological Research Pub Date : 2026-10-07 DOI: 10.1080/01616412.2026.2741929

Fawaz Al-Mufti, Mohamed Elfil, Eric Feldstein, Hazem S Ghaith, Signe Haughton, Angelique Balguid, Nagesh Uppuluri, Nick Bajema, John Murray, Priyank Khandelwal, Victor Urrutia, Nabeel Herial, Gabor Toth, Mohammad El-Ghanem, Krishna Amuluru, Viktor Szeder, Jonathan Crowe, Karol Budohoski, Zurab Nadareishvili, Kaustubh Limaye, Fazeel Siddiqui, Boris Pabon, Ossama Mansour, Atilla Özcan Özdemir, Houman Khosravani, Hamza Shaikh, Nishita Singh, Hesham Masoud, Sushanth R Aroor, Shashvat Desai, Pankajavalli Ramakrishnan, Fredrick Echols, Ameer Hassan, Santiago Ortega-Gutierrez, Syed Zaidi, Mouhammad Jumaa, Thanh N Nguyen, Dileep Yavagal, Ali Alaraj, Kaiz Asif

引用次数: 0