Neurological Research最新文献

Association between the balance recovery and the independence after a severe stroke.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1080/01616412.2025.2472835

Christian Gath, Vanina Lado, Matías Gianella, Lucas Bonamico, María J Russo

{"title":"Association between the balance recovery and the independence after a severe stroke.","authors":"Christian Gath, Vanina Lado, Matías Gianella, Lucas Bonamico, María J Russo","doi":"10.1080/01616412.2025.2472835","DOIUrl":"10.1080/01616412.2025.2472835","url":null,"abstract":"Objectives: Research is lacking on the recovery of subjects who have suffered a stroke and have severely impaired balance in the subacute stage. This study aims to analyze the association between balance recovery during inpatient rehabilitation and the level of independence in activities of daily living at discharge in severe subacute stroke patients. Secondarily, it aims to analyze the association between balance at the admission of inpatient rehabilitation after stroke and the level of independence in activities of daily living at discharge in the same sample.Methods: A longitudinal retrospective observational cohort study was conducted. Subacute post-stroke patients who could not stand at admission were included (n = 80). A correlation analysis was undertaken. The Functional Independence Measure was used to evaluate activities of daily living performance and the Berg Balance Scale to assess balance.Results: Correlation between balance recovery during inpatient rehabilitation and the level of independence at discharge: Spearman's rho = 0.741 (p < 0.001). Correlation between the Balance at admission and the level of independence at discharge: Spearman's rho = 0.288 (p = 0.009).Discussion: Monitoring balance recovery after a severe stroke may be necessary to establish functional goals during inpatient rehabilitation. Low functional independence at discharge from inpatient rehabilitation post stroke cannot always be expected in subjects with severe balance impairment at admission.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"277-283"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1080/01616412.2025.2472828

Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge

{"title":"F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?","authors":"Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge","doi":"10.1080/01616412.2025.2472828","DOIUrl":"10.1080/01616412.2025.2472828","url":null,"abstract":"Objectives: Motor unit number estimation (MUNE) methods including the one using F-waves (F-MUNE) are used to detect axonal loss in polyneuropathies. The aim of this study is to evaluate the amount of axonal loss by repeater F-wave parameters and F-MUNE in patients with type 2 diabetes mellitus (DM).Methods: In 24 controls and 49 patients with diabetic polyneuropathy, 90 F-waves elicited with supramaximal and 300 F-waves with submaximal stimulation of the ulnar nerve were recorded from the abductor digiti minimi muscle. F-MUNE values were calculated using the automated software with the repeater F-waves elicited using submaximal stimulation.Results: Ulnar repeater F-wave index and repeater neuron index were found to be significantly higher in patients with DM compared with the control group. The amplitudes of F-waves elicited using both sub- and supramaximal stimulus intensities were reduced in patients with polyneuropathy when compared with controls. The F-MUNE values were found to be similar between the two groups.Discussion: Repeater F-wave parameters recorded from the upper extremity might indicate the presence of axon loss in DM-related polyneuropathy. However, F-MUNE failed to reveal axonal loss in diabetic polyneuropathy probably because of its length-dependent nature and the dominance of low-amplitude F-waves, which might be secondary to several yet unknown mechanisms, mainly related to sensory fiber dysfunction.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"258-266"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1080/01616412.2025.2470712

Ali Mojaver, Mojtaba Khazaei, Mohammad Ahmadpanah, Mohammad Zarei, Sara Soleimani Asl, Parisa Habibi, Siamak Shahidi

{"title":"Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.","authors":"Ali Mojaver, Mojtaba Khazaei, Mohammad Ahmadpanah, Mohammad Zarei, Sara Soleimani Asl, Parisa Habibi, Siamak Shahidi","doi":"10.1080/01616412.2025.2470712","DOIUrl":"10.1080/01616412.2025.2470712","url":null,"abstract":"Objectives: Ischemic stroke is one of the most common neurological disorders. Oxidative stress, inflammation, and the reduction of Brain-Derived Neurotrophic Factor (BDNF) are implicated in cell death during ischemic stroke. Several studies suggest that Coenzyme Q10 (CoQ10) has antioxidant, anti-inflammatory, neuroprotective properties and can increase BDNF levels. This study investigated the effects of oral CoQ10 supplementation on oxidative stress biomarkers Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), Malondialdehyde (MDA), Total Thiol Groups (TTG) - as well as serum levels of Interleukin-6 (IL-6) and BDNF in ischemic stroke patients.Methods: Fifty patients hospitalized for acute ischemic stroke were randomly divided into two groups: placebo (n = 25) and CoQ10 (600 mg/day) supplementation (n = 25). The intervention began 24 hours after stroke onset and continued for 30 days.Results: Significant reductions in serum MDA and IL-6 levels, alongside increased SOD and BDNF levels, were observed in the CoQ10 group. No significant differences were found in TAC or TTG levels between the groups.Conclusions: A 30-day regimen of CoQ10 (600 mg/day) resulted in reduced oxidative stress and inflammation, alongside increased BDNF, suggesting potential neuroprotective benefits for post-stroke rehabilitation. CoQ10 May be considered a therapeutic option for enhancing neuroprotection and rehabilitation in stroke patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"232-241"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an in vitro study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1080/01616412.2025.2470714

Haizhen Jia, Huajun Fan, Jiarui Liang, Runqing He

{"title":"Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an in vitro study.","authors":"Haizhen Jia, Huajun Fan, Jiarui Liang, Runqing He","doi":"10.1080/01616412.2025.2470714","DOIUrl":"10.1080/01616412.2025.2470714","url":null,"abstract":"Objective: Ferroptosis, a regulated cell death pathway driven by lipid peroxidation and iron overload, is implicated in neuronal injury caused by hypoxia/reoxygenation (H/R). Caffeine, a widely consumed psychoactive compound, has shown neuroprotective effects in various central nervous system disorders, but its role in regulating ferroptosis remains unclear. This study investigates the neuroprotective effects of caffeine on ferroptosis and its regulation of ACSL4, a key ferroptosis-related protein.Methods: Molecular docking was performed to evaluate the interaction between caffeine and ferroptosis-related proteins ACSL4 and GPX4. HT-22 cells were subjected to H/R to establish an in vitro injury model, followed by treatment with caffeine at varying concentrations. ACSL4 was silenced or overexpressed to explore its role in caffeine-mediated ferroptosis regulation. Cell viability, inflammatory cytokines, ferroptosis markers, and mitochondrial function were assessed.Results: Molecular docking revealed favorable binding affinities of caffeine with ACSL4 (-5.6 kcal/mol) and GPX4 (-4.6 kcal/mol). Caffeine treatment dose-dependently improved cell viability, reduced TNF-α, IL-1β, and IL-6 levels, and inhibited ferroptosis by downregulating ACSL4 and upregulating GPX4. Overexpression of ACSL4 reversed these protective effects, increasing lipid peroxidation markers (iron, Fe2+, ROS, and MDA) and reducing GSH levels and mitochondrial membrane potential. Conversely, silencing ACSL4 enhanced caffeine's protective effects, confirming its role as a critical target of caffeine-mediated ferroptosis inhibition.Conclusion: Caffeine protects against H/R-induced neuronal injury by regulating ACSL4-mediated ferroptosis, reducing oxidative stress and inflammation. These findings highlight ACSL4 as a therapeutic target and provide mechanistic insights into caffeine's neuroprotective potential.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"242-250"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1080/01616412.2025.2472841

Afef Achouri-Rassas, Saloua Fray, Zakaria Said, Samia Ben Sassi, Nadia Ben Ali, Ghada Baraket

{"title":"Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population.","authors":"Afef Achouri-Rassas, Saloua Fray, Zakaria Said, Samia Ben Sassi, Nadia Ben Ali, Ghada Baraket","doi":"10.1080/01616412.2025.2472841","DOIUrl":"10.1080/01616412.2025.2472841","url":null,"abstract":"Background: Alzheimer's disease (AD) is the leading cause of major neurodegenerative cognitive impairment. The risk of developing AD is influenced by a complex interaction of genetic predisposition and environmental factors. Among the genetic risk factors, the APOE ɛ4 allele is the most significant, while variants in the TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) and ABCA7 (ATP-binding cassette transporter A7) genes have also been associated with an increased risk of AD.Objective: This study aimed to investigate the association of APOE ɛ4, TREM2 gene variants (rs75932628 [p.R47H] and rs2234253 [p.T96K]), and ABCA7 gene variants (rs142076058 and rs115550680) with sporadic AD in the Tunisian population. Methods: A case-control study was conducted including 222 Tunisian patients diagnosed with sporadic AD and 99 cognitively healthy controls. Genotyping was performed to assess the presence and association of the selected genetic variants with AD. Statistical analyses were conducted to determine the significance of genetic associations.Results: A significant association was found between the TREM2 rs2234253 (p.T96K) variant and AD, with the T allele identified as a risk factor in the Tunisian population. The APOE ɛ4 allele was also associated with an increased risk of developing AD. However, no significant association was observed for the ABCA7 gene variants or the TREM2 rs75932628 (p.R47H) variant in either the AD or control groups.Conclusion: Our findings suggest that the TREM2 rs2234253 (p.T96K) variant is a significant genetic risk factor for late-onset AD (LOAD) in the Tunisian population. Further studies with larger cohorts are needed to validate these findings and explore potential gene-gene interactions contributing to AD risk.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"290-295"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can lactate levels predict progression to status epilepticus in generalized convulsive epileptic seizures?

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.1080/01616412.2025.2472829

İhsan Dengiz, Selen Acehan, Salim Satar, Muge Gulen, Sarper Sevdimbas, Mert Pehlivan, Melike Kucukceylan, Mehmet Gorur, Ali İsa Aslan, Figen Topalak

{"title":"Can lactate levels predict progression to status epilepticus in generalized convulsive epileptic seizures?","authors":"İhsan Dengiz, Selen Acehan, Salim Satar, Muge Gulen, Sarper Sevdimbas, Mert Pehlivan, Melike Kucukceylan, Mehmet Gorur, Ali İsa Aslan, Figen Topalak","doi":"10.1080/01616412.2025.2472829","DOIUrl":"10.1080/01616412.2025.2472829","url":null,"abstract":"Objective: The aim of this study was to analyze the factors predicting the progression to status epilepticus (SE) in patients who presented with generalized convulsive epileptic (GCE) seizures.Materials and methods: Patients included in the study were grouped as SE (+) and (-) patients. In addition to hemogram, biochemistry and blood gas parameters, the levels of antiepileptic drugs used by the patients at the time of presentation to the emergency department (ED) were also studied. Blood gas parameters at the 2nd hour of follow-up were retaken and lactate clearance was calculated and recorded on the data form.Results: 26.7% of the patients were SE (+). A statistically significant, moderate correlation was observed between postictal time and both lactate0(r = 0.663; p < 0.001) and lactate2levels (r = 0.626; p < 0.001). In the analyses performed for the association with the presence of SE, presence of seizures within the last week (OR: 17.15, 95% CI: 1.322-222.505, p = 0.030), lactate2(OR: 2.055, 95% CI: 1.367-3.090, p = 0.001), lactate0(OR: 1.520, 95% CI: 1.030-1.283, p = 0.006), pulse rate (OR: 1.150, 95% CI: 1.150, 95% CI: 11.012-3.054, p = 0. 045) and leukocyte (OR: 0.469, 95% CI: 0.254-0.868, p = 0.016) values were independent predictors of the presence of SE. In the ROC analysis, it was determined that lactate0value had the highest predictive power (AUC: 0.908, 95% GA 0.860-0.955, p < 0.001).Conclusion: According to the study data, the presence of a significant increase in lactate levels at emergency department presentation should alert the clinician to status epilepticus.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"267-276"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of memantine and donepezil on social memory, anxiety-like behavior and the expression levels of microRNA-124, microRNA-125b, and microRNA-132 in scopolamine-induced memory impairment in rats.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-03 DOI: 10.1080/01616412.2025.2472848

Pouria Bahmani Kolour, Hamed Ghazvini, Mobin Naderi, Hossein Ghalehnoei, Masoumeh Rezaei Talarposhti

{"title":"Effects of memantine and donepezil on social memory, anxiety-like behavior and the expression levels of microRNA-124, microRNA-125b, and microRNA-132 in scopolamine-induced memory impairment in rats.","authors":"Pouria Bahmani Kolour, Hamed Ghazvini, Mobin Naderi, Hossein Ghalehnoei, Masoumeh Rezaei Talarposhti","doi":"10.1080/01616412.2025.2472848","DOIUrl":"10.1080/01616412.2025.2472848","url":null,"abstract":"Introduction: Almost all physiological processes are modulated by microRNAs, therefore, dysregulation of these small regulatory RNAs is observed in a variety of diseases, including cognitive impairments.Methods: In this study, 40 male Wistar rats were randomly divided into five groups of control, scopolamine, donepezil, memantine, and combined administration of donepezil + memantine. Rats in scopolamine, donepezil, memantine, and combined administration of donepezil + memantine groups received scopolamine (1 mg/kg-intraperitoneal) for 7 days. After the last administration of scopolamine, was started injecting donepezil (3 mg/kg-i.p.), memantine (10 mg/kg-i.p.), and combined administration of Donepezil + Memantine (0.5 mg/kg and 5 mg/kg-i.p., respectively), up to 21 days. Twenty-four hours after the last injection, elevated plus-maze, social interaction, open field tests, and gene expression analysis of miR-124, miR-125b, and miR-132 in the hippocampus were carried out.Results: The results of the behavioral tests indicate that donepezil and memantine significantly prevented Scopolamine-induced anxiety, sociability, and social memory decline. The gene expression of selected microRNAs did not significantly differ between the groups.Discussion: This study revealed that donepezil and memantine effectively prevent synaptic plasticity disruption and cognitive decline induced by scopolamine. Findings indicated that this treatment is unrelated to the expression of the selected microRNAs. The positive effects of memantine and donepezil depend on age, dosages, cognitive task demands, and possibly the length and timing of the treatment.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"306-317"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-COVID from the perspective of neurologists at the outpatient clinic: A cross-sectional field study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1080/01616412.2025.2472824

Artemios Artemiadis, Andreas G Tofarides, Andreas Liampas, Christiana Ioannou, Katerina Christodoulou, Rafaela Louka, George Vavougios, Panagiotis Zis, Panagiotis Bargiotas, Georgios Hadjigeorgiou

{"title":"Long-COVID from the perspective of neurologists at the outpatient clinic: A cross-sectional field study.","authors":"Artemios Artemiadis, Andreas G Tofarides, Andreas Liampas, Christiana Ioannou, Katerina Christodoulou, Rafaela Louka, George Vavougios, Panagiotis Zis, Panagiotis Bargiotas, Georgios Hadjigeorgiou","doi":"10.1080/01616412.2025.2472824","DOIUrl":"10.1080/01616412.2025.2472824","url":null,"abstract":"Objectives: Approximately 25% of individuals experience various symptoms months after the COVID-19 infection and are referred to as having Long-COVID syndrome. The primary objective of this study was to identify the pattern of neuropsychiatric symptoms and their influence on psychological health, sleep quality, and overall well-being.Methods: In this cross-sectional study, Long-COVID patients reported on their symptoms by using a predefined list. The symptom patterns were examined using cluster analysis. The clustering groups were compared based on psychological health, sleep, and well-being scores obtained from structured questionnaires.Results: There were 40 females and 13 males, with a mean age of 54.1 ± 12.2 years. The most frequently reported symptoms were fatigue (94.3%), followed by anxiety (79.2%), myalgias (75.5%), and concentration difficulties (71.7%). Clustering analysis revealed two clusters separated by the number of cognitive, psychiatric, general neurologic, and somatic symptoms (i.e. high and low number). Patients within the high number cluster reported significantly more symptoms of depression, anxiety and stress, and worse quality of sleep than the low number cluster. Overall, 32 patients (60.4%) were found to have poor well-being. Reporting more than 17 symptoms (58.6% of patients) predicted poor well-being with a sensitivity of 37.5% and specificity of 95.2% (p = 0.011).Discussion: In this study, Long-COVID patients presenting at the outpatient neurologic clinic were clustered based on the number of symptoms instead of the nature of these symptoms. A higher number of symptoms were associated with poorer psychological health, sleep quality, and overall well-being.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"251-257"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Education level and health profile related to global cognitive impairment in an urban community in West Jakarta, Indonesia.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-23 DOI: 10.1080/01616412.2025.2470709

Yvonne Suzy Handajani, Yuda Turana, Kevin Kristian, Nelly Tina Widjaja, Aylenia Lysandra, Elisabeth Schröder-Butterfill, Antoninus Hengky

{"title":"Education level and health profile related to global cognitive impairment in an urban community in West Jakarta, Indonesia.","authors":"Yvonne Suzy Handajani, Yuda Turana, Kevin Kristian, Nelly Tina Widjaja, Aylenia Lysandra, Elisabeth Schröder-Butterfill, Antoninus Hengky","doi":"10.1080/01616412.2025.2470709","DOIUrl":"10.1080/01616412.2025.2470709","url":null,"abstract":"Objectives: This study aims to investigate the association of global cognitive with chronic conditions, physical impairment, olfactory function, socio-demographics and other factors among older adults in the urban community, West Jakarta.Materials and methods: The cross-sectional study involved 334 older adults aged 60 years and older who resided in urban community Jakarta, Indonesia. Trained interviewers visited and evaluated the respondents in the sub-district office. Cognitive function is examined using Montreal Cognitive Assessment-Indonesian Version (MoCA-INA). Respondents were clinically examined using a standardized protocol, which included medical history, general physical examination, cognitive assessment, and blood test for diabetes.Results: Global cognitive impairment was significantly associated with being female (adjusted odd ratio [AOR]: 1.99, 95% CI: 1.14-3.50) and low education (AOR: 4.79, 95% CI: 2.80-8.18). Moreover diabetes, impaired balance, and olfactory dysfunction have AOR:3.23 (95% CI: 1.39-7.51), 2.55% (95% CI: 1.07-6.07), and 2.26 (95% CI: 1.32-3.85) respectively.Conclusion: This paper highlights that cognitively impaired and diabetic as well as low education subject in urban community, West Jakarta, Indonesia. Global cognitive impairment was associated with being female, having obtained low levels of education, having diabetes, impaired balance and olfactory dysfunction.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"223-231"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1080/01616412.2025.2472836

Aysu Yetis, Asuman Celikbilek, Bilal Ilanbey, Naime Meric Konar, Selcen Duran

引用次数: 0