Neurological Research最新文献

{"title":"Prediction is not permission: why artificial intelligence-aided neuroprognostication needs a decision firewall.","authors":"Satheeshram Tamilselvan, Finn McCarthy, Ali Alaraj","doi":"10.1080/01616412.2026.2727915","DOIUrl":"https://doi.org/10.1080/01616412.2026.2727915","url":null,"abstract":"","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of gastrostomy tube placement and outcomes in stroke patients: a systematic review and meta-analysis of early versus deferred placement.","authors":"Adnan I Qureshi, Ather Iqbal, Gunjanpreet Kaur, Ahmed Hassan, Adar Nebioglu, Emrah Aytac, Daniel E Ford, Chun Shing Kwok, Lourdes Carhuapoma, Maureen Lefton-Greif, Andrea Loggini, David R Mehr, Lisa A Royse, Nae-Yuh Wang, Daniel F Hanley","doi":"10.1080/01616412.2026.2693798","DOIUrl":"https://doi.org/10.1080/01616412.2026.2693798","url":null,"abstract":"<p><strong>Background: </strong>Gastrostomy tube placement provides long-term enteral access for stroke patients with persistent dysphagia, but the optimal timing of gastrostomy tube placement remains uncertain. Early gastrostomy tube placement may facilitate rehabilitation and discharge, but concerns remain about the necessity of the procedure in patients who may recover swallowing function.</p><p><strong>Methods: </strong>We conducted a systematic review of studies that evaluated the timing of gastrostomy tube placement in patients with stroke. Early placement was defined as gastrostomy tube placement within 7 days of the qualifying stroke event or admission. Random-effects meta-analysis was used to pool binary outcomes as risk ratios (RRs), and hospital length of stay was pooled as a mean difference (MD). The primary analysis was restricted to studies using a ≤7-day cutoff, with a sensitivity analysis that incorporated one study using a ≤14-day cutoff.</p><p><strong>Results: </strong>Four studies (245,553 patients) using a ≤7-day definition were analyzed, with one additional study (≤14-day definition) included as a sensitivity analysis. Early gastrostomy tube placement was associated with significantly shorter hospital length of stay (4 studies; MD, -11.38 days; 95% CI, -15.56 to -7.20; <i>p</i> < 0.001; I² = 99.9%). Early placement was also associated with a significantly lower risk of venous thromboembolism (3 studies; RR, 0.47; 95% CI, 0.32-0.69; <i>p</i> < 0.001; I² = 97.3%). No significant differences were observed for mortality (4 studies; RR, 1.08; 95% CI, 0.61-1.94; <i>p</i> = 0.78; I² = 99.6%), pneumonia (2 studies; RR, 0.55; 95% CI, 0.23-1.31; <i>p</i> = 0.17; I² = 83.2%), or discharge to a destination other than home (3 studies; RR, 0.97; 95% CI, 0.89-1.06; <i>p</i> = 0.53; I² = 99.5%). A sensitivity analysis incorporating the ≤14-day study did not materially change the length-of-stay or mortality estimates.</p><p><strong>Conclusions: </strong>Early gastrostomy tube placement after stroke was associated with shorter hospitalization and lower risk of venous thromboembolism, without a clear effect on mortality, pneumonia, or discharge disposition.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomarker dynamics for predicting clinical outcomes and hemorrhagic transformation in acute ischemic stroke:A prospective cohort study.","authors":"Hongyan Li, Xuegang Meng, Zhu Li, Lingling Wang, Chunli Zhang, Qing Li, Dilmurat Amit, Guoqing Bao, Mingyuan Wang, Fu Xu, Xiao Hu, Huan Lei, Wanting Lei, Yingzi Wang, Chuang Liu, Zimeng Li","doi":"10.1080/01616412.2026.2697011","DOIUrl":"https://doi.org/10.1080/01616412.2026.2697011","url":null,"abstract":"<p><strong>Background: </strong>Acute ischemic stroke (AIS) has high disability and mortality. Hemorrhagic transformation (HT) is a critical complication related to astrocyte damage, axonal injury and inflammation. GFAP, NfL and IL-6 are closely associated with HT, but 7-day continuous dynamic data are lacking.</p><p><strong>Objective: </strong>To investigate 7-day dynamic changes of serum GFAP, NfL, IL-6 and their predictive value for HT and 3-month functional outcomes in AIS patients.</p><p><strong>Methods: </strong>A prospective cohort study including 308 AIS patients. Serum biomarkers were measured daily for 7 days. Predictive performance was analyzed by Cox regression, ROC analysis, calibration, and decision curve analysis (DCA).</p><p><strong>Results: </strong>HT occurred in 13.6% (42/308) of patients. The 24-hour GFAP change rate independently predicted HT (HR = 1.041, 95% CI: 1.015-1.069, <i>p</i> = 0.002). The combined model had a bootstrap-corrected C-index of 0.877. Peak GFAP improved 3-month outcome prediction (AUC = 0.850, <i>p</i> = 0.048), outperforming NfL and IL-6.</p><p><strong>Conclusion: </strong>The 24-hour GFAP change rate is a potential predictor for HT. Serial GFAP monitoring may provide preliminary evidence for early risk stratification of HT and functional outcomes in AIS patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygonatum sibiricum polysaccharide ameliorates neurotoxicity in Alzheimer disease mice by inhibiting endoplasmic reticulum stress and lipid raft formation through AMPK/GSK3β/Nrf2 pathway.","authors":"Shixing Wu, Wei Liu, Changying Zhang","doi":"10.1080/01616412.2025.2559431","DOIUrl":"10.1080/01616412.2025.2559431","url":null,"abstract":"<p><strong>Background: </strong>Polygonatum sibiricum polysaccharide (PSP) is known for its anti-inflammatory and cognitive improvement effects. However, its potential to alleviate neurotoxicity in Alzheimer's diseafse (AD) has not been thoroughly explored. This study aims to investigate the effects of PSP on AD and clarify its underlying mechanisms.</p><p><strong>Methods: </strong>Behavioral tests were conducted using Y-maze and Morris water maze in SAMP8 and SAMR1 mice. Histopathological changes were assessed via ThT and TUNEL staining. Immunofluorescence co-localization and ELISA measured amyloid β-protein (Aβ) levels and inflammatory cytokines. Microglia and astrocyte activation were detected by immunohistochemistry. Oxidative stress and the AMPK/GSK3β/Nrf2 pathway were examined through Western blot.</p><p><strong>Results: </strong>SAMP8 mice exhibited impaired learning and memory, significantly improved by PSP. PSP reduced amyloid plaque load, neuroinflammation, microglia/astrocyte activation, oxidative stress, and neuronal apoptosis in SAMP8 mice. PSP inhibited Aβ production and lipid raft formation in the endoplasmic reticulum-mitochondrial membrane. Activation of the AMPK/GSK3β/Nrf2 pathway was observed, with AMPK inhibition reducing PSP's protective effects.</p><p><strong>Conclusion: </strong>PSP alleviates neurotoxicity in AD model mice by inhibiting ER stress and lipid raft formation via the AMPK/GSK3β/Nrf2 pathway.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1235-1252"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AATF alleviates cerebral ischemia-reperfusion injury by suppressing endoplasmic reticulum stress-induced ferroptosis through upregulating the PI3K/Akt pathway.","authors":"Bo Lei, Wenzhang Luo, Qinjing Li, Honggang Wu, Li Chen, Shu Chen, Jiachuan Wu, Niandong Zheng","doi":"10.1080/01616412.2025.2564226","DOIUrl":"10.1080/01616412.2025.2564226","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to investigate the role of apoptosis-antagonizing transcription factor (AATF) in regulating endoplasmic reticulum (ER) stress-ferroptosis interaction and its neuroprotective mechanism in cerebral ischemia-reperfusion injury (CIRI).</p><p><strong>Methods: </strong>Two models were used: oxygen-glucose deprivation/reperfusion (OGD/R)-induced hippocampal neuron cells and transient middle cerebral artery occlusion/reperfusion (tMCAO/R)-induced rats. AATF overexpression and knockdown were respectively performed to assess its impact on neuronal injury. Ferroptosis biomarkers - glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1), iron responsive element binding protein 2 (IREB2) and ER stress markers - phosphorylated eukaryotic initiation factor 2α (p-EIF2α)/EIF-2α, activating transcription factor 4 (ATF4) were analyzed by Western blot and enzyme-linked immunosorbent assay (ELISA). Pharmacological inhibitors or activators were utilized to explore the regulatory relationship between AATF, ER stress, and ferroptosis.</p><p><strong>Results: </strong>AATF was significantly upregulated during CIRI. AATF overexpression improved neuronal viability, reduced reactive oxygen species (ROS), and alleviated ferrous ion (Fe²⁺) accumulation; conversely, endogenous knockdown of AATF reversed its neuroprotective effects. Pathologically, AATF reduced cerebral infarction volume, neurological deficits, and brain edema. Mechanistic analysis showed that AATF inhibited the ER stress-ferroptosis axis by regulating related proteins. Pharmacological phosphatidylinositol 3-kinase (PI3K) inhibition reversed the neuroprotective effects of AATF, indicating the essential role of the PI3K- protein kinase B (Akt) signaling pathway in AATF-mediated suppression of both ferroptosis and ER stress.</p><p><strong>Discussion: </strong>AATF mitigates CIRI injury by modulating the ER stress-ferroptosis axis, primarily through the activation of the PI3K-Akt signaling pathway. These findings position AATF as a promising therapeutic target for brain ischemia-reperfusion injury.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1315-1331"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific behavioral impairments and neuronal alterations in Wistar rats following repeated sevoflurane exposure during developmental stages.","authors":"Mahdieh Nasiri, Amir Barzegar Behrooz, Soheila Adeli, Nitesh Sanghai, Seyed Khalil Pestehei, Javad Fahanik Babaei","doi":"10.1080/01616412.2025.2559303","DOIUrl":"10.1080/01616412.2025.2559303","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the effects of repeated exposure to sevoflurane as an anesthetic agent during various developmental stages, namely neonatal, preadolescent, and adult, on behavioral, synaptic, and neuronal plasticity in male and female Wistar rats.</p><p><strong>Methods: </strong>Rats were exposed to sevoflurane during three developmental stages: neonatal (PN7), pre-adolescence (PN28), and adulthood (PN90). Behavioral performance was evaluated with the Morris Water Maze. Electrophysiological analyses measured population spike (PS) amplitude, slope, and long-term potentiation (LTP) to assess synaptic plasticity. Short-term plasticity was additionally studied using paired-pulse facilitation tests.</p><p><strong>Results: </strong>Repeated neonatal exposure to sevoflurane caused significant impairments in spatial learning and memory, whereas exposures during pre-adolescence and adulthood had minimal effects. Electrophysiological data revealed a reduction in PS amplitude and slope, as well as impaired LTP, particularly in neonatal and pre-adolescent groups, with more severe deficits observed in males. Paired-pulse facilitation indicated greater short-term plasticity deficits in males at shorter intervals.</p><p><strong>Discussion: </strong>The findings of this study highlight the increased vulnerability of the developing brain, particularly during the neonatal period, to the adverse effects of repeated exposure to sevoflurane, resulting in long-lasting impairments in synaptic function and behavior. The results emphasize the importance of caution when administering sevoflurane to young children and suggest that early-life exposure may have lasting effects on cognitive and synaptic health.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1169-1186"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(Holo-PACS): use of holograms to improve provider acumen when reading clinical radiographic scans.","authors":"Brett C Meyer, Ben Shifflett, Weichen Liu, Kunal Agrawal, Dawn M Meyer, Reza Bavarsad Shahripour, Royya Modir, Thomas M Hemmen, Sanad Batarseh, Marissa D'Souza, Tiffany Hu, Cattien Phan, Amy Radonich, Nadir Weibel","doi":"10.1080/01616412.2026.2714537","DOIUrl":"10.1080/01616412.2026.2714537","url":null,"abstract":"<p><strong>Background and purpose: </strong>Vascular Neurology (VN) fellowship education in CTA interpretation is critical, given the increased opportunities for tissue salvage via neurointervention. Holo-Stroke-CTA 3D visualization has already shown improved accuracy and satisfaction for vessel occlusion detection. Our aim in this present analysis was to determine if focused education in CTA reading, including addition of Holo-Stroke-CTA and immediate access to clinical PACS images during team meetings (Holo-PACS), would improve fellow and team education.</p><p><strong>Methods: </strong>Four VN fellows scored 3 sets of de-identified CTAs (DICOM Group-A (<i>n</i> = 12), DICOM Group-B (<i>n</i> = 12), and Holo-Stroke-CTA Group-C (<i>n</i> = 24) to assess for LVOs/MeVOs. After each set, a training session was given. Concurrently, Holo-PACS, accessing our enterprise PACS system via secure Intranet, was utilized in weekly team conferences. Likert surveys assessed satisfaction. Wilcoxon Signed Rank was used for non-parametric, and Exact Binomial Test was used for preference comparisons.</p><p><strong>Results: </strong>The overall correct percentage was 63% DICOM Group A vs. 97% Group C Holo-PACS. MCA (75%,94%), ICA (75%,100%), and Basilar (100%,100%) locations scored high, with marked improvement for ACA (13%,100%), and PCA (38%,94%). Likert satisfaction overall was 47% DICOM vs. 94% Holo-PACS. 'Satisfaction' scores were (55%,90%), 'Immersion' (34%,96%), 'Ease of Use' (53%,87%), 'Accuracy' (55%,93%), 'Technology Advancement' (42%,98%), and 'Enthusiasm' (45%,97%).</p><p><strong>Conclusions: </strong>The Holo-PACS initiative, including focused CTA education and implementing both Holo-Stroke-CTA and secure connection to PACS imaging using Holo-PACS during weekly team meetings, resulted in an improved ability to interpret CTAs and robust immersive satisfaction. Holo-PACS is becoming integral to our stroke education and training, and may serve as a model for vascular neurology fellowship training programs.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical evacuation of acute subdural hematomas in patients aged 65 years or older - a bicentric experience.","authors":"Thomas Eibl, Carlos Moreno Beredjiklian, Adrian Liebert, Leonard Ritter, Markus Neher, Michael Schrey, Christoph Schwartz, Christoph J Griessenauer, Karl-Michael Schebesch","doi":"10.1080/01616412.2025.2563212","DOIUrl":"10.1080/01616412.2025.2563212","url":null,"abstract":"<p><strong>Objective: </strong>The optimal treatment of elderly patients with acute subdural hematomas (aSDH) remains a subject of ongoing debate. This study aimed to analyze the clinical course of patients aged 65 years or older who underwent craniotomy for aSDH evacuation. Risk factors for poor clinical outcome have not been thoroughly reported in larger cohorts.</p><p><strong>Methods: </strong>Patients who underwent craniotomy for acute or subacute subdural hematomas between 2013 and 2022 at two tertiary neurosurgical centers were retrospectively reviewed. Primary outcome measures included in-hospital mortality and clinical outcome, with Glasgow Outcome Scale (GOS) ≥4 defined as a good outcome.</p><p><strong>Results: </strong>One-hundred-sixty patients (61.3% males) with a mean age of 75.9 ± 6.0 years at surgery were included. In-hospital mortality was 44.4%, 26.3% were discharged with GOS ≥ 4. Risk factors for mortality included midline shift on pre- (<i>p</i> = 0.036) and postoperative computed tomography (CT) scan (<i>p</i> = 0.00042), preoperatively dilated pupils (<i>p</i> = 0.0012), preoperative GCS ≤ 8 (<i>p</i> = 0.010), and the presence of intraparenchymal hemorrhage (<i>p</i> = 0.025). Among patients discharged with GOS < 4, 12 of 35 (34.3%) were able to return to their homes and regained a mostly independent functional status after rehabilitation.A prognostic score comprising age >75 years, midline shift >17.5 mm, parenchymal hemorrhage and dilated pupil was established to predict mortality (AUC = 0.739, 95%CI = 0.661-0.817, <i>p</i> = 0.00000022) and unfavorable outcome at discharge from hospital (AUC = 0.747, 95%CI = 0.666-0.827, <i>p</i> = 0.000002).</p><p><strong>Conclusion: </strong>Our study demonstrated high morbidity and mortality rates following craniotomy for aSDH evacuation in elderly patients. The extent of intracranial injury emerged as the primary prognostic factor for poor clinical outcomes.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1303-1314"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of interhospital transfer on patients undergoing endovascular thrombectomy for acute ischemic stroke from a comprehensive stroke center.","authors":"Saqib A Chaudhry, Aysha Jadran, Zarina Laleka, Mohammad Rauf Chaudhry, Heela Afzal, Jing Wang, Zelalem Bahiru, Fang Yun, Pouya Tahsili Fahadan, Laith Altaweel, Adnan I Qureshi, Ashfaq Shuaib","doi":"10.1080/01616412.2025.2560070","DOIUrl":"10.1080/01616412.2025.2560070","url":null,"abstract":"<p><strong>Background: </strong>Patients with acute stroke frequently require transfer to a comprehensive stroke center (CSC) for endovascular thrombectomy (EVT). We studied the impact of the transfer on functional outcomes for acute ischemic stroke caused by large vessel occlusion (LVO).</p><p><strong>Methods: </strong>We conducted a retrospective analysis using data from a prospective stroke registry on patients who underwent EVT for LVO between January 2019 and June 2024 at a CSC.</p><p><strong>Results: </strong>Three hundred and seventy-six of seven hundred seventy three patients were transferred to the CSC and were significantly younger (67.4 ± 15.2 vs. 71.7 ± 15.0, p-value = 0.0002). No significant differences were observed in baseline characteristics, including gender, admission National Institutes of Health Stroke Scale (NIHSS), and the rate of intravenous thrombolysis between the two groups. The time from symptom onset to groin puncture was significantly longer for the transfer group (690.1 min vs. 486.0 min, <i>p</i> < 0.0001). The time of symptom onset to reperfusion time was also longer for the transfer group (713.3 min vs. 521.8 min, <i>p</i> < 0.0001). The groin puncture to reperfusion time (39.0 min vs. 36.8 min, <i>p</i> = 0.2183), and door-in to reperfusion time (312 min vs. 223.3 min, <i>p</i> = 0.0731), were comparable between the two cohorts. Likewise, the rates of successful reperfusion TICI grade ≥2B, symptomatic intracranial hemorrhage (sICH), discharge to home, and in-hospital mortality were similar between the two groups (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Despite significantly longer time intervals from symptom onset to the initiation of mechanical thrombectomy in transfer patients, there were no adverse consequences on prognosis.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1253-1260"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with cerebral microbleeds detected after intravenous thrombolysis in acute ischemic stroke patients based on SWI.","authors":"Ting Zhang, Junliang Pu, Zhe Kang, Xuanqin Wang","doi":"10.1080/01616412.2026.2718511","DOIUrl":"https://doi.org/10.1080/01616412.2026.2718511","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the independent factors associated with the detection of cerebral microbleeds (CMBs) after intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) based on susceptibility-weighted imaging (SWI).</p><p><strong>Methods: </strong>This was a retrospective analysis of 157 AIS patients who received IVT. Based on post-thrombolysis SWI findings, patients were divided into a CMBs+ group (<i>n</i> = 75) and a CMBs- group (<i>n</i> = 82). Clinical data were collected. Univariate analysis was used to screen variables, and those with <i>p</i> < 0.05 were incorporated into a multivariate logistic regression model to identify independent factors associated with CMBs.</p><p><strong>Results: </strong>Univariate analysis showed that activated partial thromboplastin time (APTT), international normalized ratio (INR), smoking history, history of lacunar infarction, white matter hyperintensities (WMH), and history of antithrombotic medication use were associated with CMB occurrence (<i>p</i> < 0.05). Multivariate analysis further confirmed that WMH (OR = 29.92, 95% CI: 6.94-128.95), history of lacunar infarction (OR = 17.70, 95% CI: 5.00-62.61), and smoking history (OR = 4.55, 95% CI: 1.37-15.16) were independent factors associated with CMBs (<i>p</i> < 0.05). Age, pre-thrombolysis NIHSS score, and coagulation parameters did not enter the final model.</p><p><strong>Conclusion: </strong>Cerebral small vessel disease (manifested as white matter hyperintensities and lacunar infarction) is the most significant factor associated with CMBs detected after IVT, and smoking is an important modifiable behavioral risk factor. Clinical decision‑making should pay particular attention to AIS patients with markers of cerebral small vessel disease.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}