Neurological Research最新文献

{"title":"Pattern of anti-seizure medications and predictors of depression in people with epilepsy.","authors":"Ogunjimi Luqman, Ogunjimi Olabisi, Alabi Akinyinka, Aderinola Aderonke, Murtala Akanji, Oyenuga Ibironke, Kasumu Emmanuel, Alli Khadijat, Fagbemi Ayotomiwa, Akindolani Precious, Akinbodu Shittabey, Ottun Kofoworola, Adeyemo Stella, Johnson Deborah, Oluseyije Oluwatobiloba, Kasali Adeola, Osalusi Bamidele, Fehintola Fatai","doi":"10.1080/01616412.2025.2571953","DOIUrl":"https://doi.org/10.1080/01616412.2025.2571953","url":null,"abstract":"<p><strong>Method: </strong>This cross-sectional study recruited 940 PWE attending outpatient clinics of selected tertiary hospitals in southwestern Nigeria, with diagnosis confirmed clinically and supported by electroencephalography (EEG), aged ≥15 years, with no history of psychogenic non-epileptic seizures. Zung Self-Rating Depression Score (ZSRDS) was used to assess depression, and Liverpool Adverse Event Profile (LAEP) was used to assess the adverse effects of ASM.</p><p><strong>Results: </strong>The prevalence of depression was 44.5%. In multivariable logistic regression, independent predictors of depression included younger age (OR 0.94, <i>p</i> < 0.001), higher age of seizure onset (OR 1.09, <i>p</i> < 0.05), seizure duration < 2 years (OR 1.76, <i>p</i> = 0.032), lower mean LAEP score (OR 0.90, <i>p</i> < 0.001), not being on an ASM (OR 2.12, <i>p</i> = 0.001), and ASM duration < 2 years (OR 4.15, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>While depression is prevalent among PWE, adverse events, non-use of ASM, and duration of ASM use were among the predictors of depression. Health care providers should work towards preventing adverse events and achieving early seizure control with appropriate pharmacotherapeutic intervention.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of a composite NLR-PLR index for neurological recovery after EVT in AIS-LVO patients.","authors":"Weiye Wang, Shenlong Liu, Yazhao Sun, Xiao Yu, Wenfang Hu, Tianci Liang","doi":"10.1080/01616412.2025.2569614","DOIUrl":"https://doi.org/10.1080/01616412.2025.2569614","url":null,"abstract":"<p><strong>Background: </strong>To evaluate whether a combined neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) index enhances the prediction of short-term functional outcomes in patients with anterior circulation large vessel occlusion (AIS-LVO) undergoing endovascular therapy (EVT).</p><p><strong>Methods: </strong>We retrospectively enrolled 259 AIS-LVO patients who underwent EVT between September 2022 and September 2024. NLR and PLR were dichotomized using optimal ROC-derived cutoff values (NLR > 4.783, PLR > 185.931) and assigned binary scores. These were summed to construct a composite index ranging from 0 to 2, and patients were grouped into Y1-Y4 categories. The primary outcome was 90-day functional outcome, measured by modified Rankin Scale (mRS).</p><p><strong>Results: </strong>The combined index outperformed NLR or PLR alone in predicting 90-day outcomes (AUC = 0.676). Patients in Y4 (both high NLR and PLR) had the highest rate of unfavorable outcomes, while Y1 (both low) had the lowest. Logistic regression confirmed independent associations of both NLR and PLR with prognosis.</p><p><strong>Conclusion: </strong>A composite NLR-PLR index may help to stratify short-term functional prognosis in AIS-LVO patients after EVT, potentially supporting individualized risk assessment in clinical settings.The combined index formed by NLR and PLR groups may provide an improved prediction of short-term functional outcomes for AIS-LVO patients after thrombectomy. Stratification by Y1-Y4 groupings enables clinicians to identify high-risk patients more precisely and tailor early interventions accordingly.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose heparin reduces radial artery injury in transradial cerebral angiography: a 375-case retrospective study.","authors":"Rongxin He, Xiaohan Zhang, Lingwan Yan, Min Tao, Tian Wang, Cai Zhong, Kaimin Xiao, Lu Gan, Man Luo","doi":"10.1080/01616412.2025.2568027","DOIUrl":"https://doi.org/10.1080/01616412.2025.2568027","url":null,"abstract":"<p><strong>Background: </strong>Transradial cerebral angiography carries a risk of radial artery injury, which may affect subsequent approaches for angiography or endovascular therapy. The role of heparin in mitigating this risk remains controversial.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of heparin in preventing radial artery injury with transradial cerebral angiography. Methods: In a single-center retrospective study, we analyzed 375 patients undergoing diagnostic cerebral angiography via the right radial approach between August 2022 and July 2025. Patients were stratified by heparin dose: no heparin (<i>n</i> = 235), low-dose (30 IU/kg, <i>n</i> = 90), or standard-dose (60 IU/kg, <i>n</i> = 50). Primary outcomes included radial artery injury, ecchymosis, pain and ischemic manifestations. Statistical analyses employed Kruskal-Wallis and chi-square tests with Bonferroni correction for multiple comparisons. Results: Radial artery injury was significantly lower with heparin administration (low-dose: 3.3% [3/90]; standard-dose: 2.0% [1/50]) versus no heparin (14.5% [34/235]; both <i>p</i> < 0.0167), with no difference between heparin doses (<i>p</i> = 0.21). No intergroup differences were observed in ecchymosis (2.1% vs. 1.1% vs. 2.0%, <i>p</i> = 0.83) or pain (4.3% vs. 2.2% vs. 2.0%, <i>p</i> = 0.56). Ischemic manifestations (pallor) occurred exclusively in the no-heparin group (3.4%, 8/235; <i>p</i> = 0.088).</p><p><strong>Conclusions: </strong>Low-dose heparin (30IU/kg) significantly reduces radial artery injury rates without increasing risk of ecchymosis. Routine administration of low-dose heparin through the arterial sheath is recommended to protect radial artery.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of myasthenia gravis management: a cross-sectional study at a Korean tertiary center.","authors":"Ye Joon Jung, Ha Young Shin, Hyung Jun Park, Seung Woo Kim","doi":"10.1080/01616412.2025.2568028","DOIUrl":"https://doi.org/10.1080/01616412.2025.2568028","url":null,"abstract":"<p><strong>Introduction: </strong>The clinical course and treatment response of myasthenia gravis (MG) vary widely, requiring a comprehensive understanding of treatment outcomes. However, real-world data on Korean MG patients remain limited. This study aimed to evaluate treatment outcomes in Korean MG patients at a specific cross-sectional time point.</p><p><strong>Methods: </strong>This retrospective analysis included MG patients who had outpatient visits between October 2023 and September 2024. We assessed treatment outcomes at the index date, including the proportion achieving MM-5-defined as minimal manifestations or better with corticosteroid use ≤5 mg/day - and the proportion meeting criteria for refractory MG.</p><p><strong>Results: </strong>A total of 668 patients were included. At the index date, 16.3% were in pharmacologic remission, 45.1% in minimal manifestation, and 4.9% showed worsening disease. Overall, 48.1% achieved MM-5. The MM-5 rate was 51.9% among those treated with one immunosuppressant but declined to 17.1% in those who had been treated with three. MM-5 was achieved in 41.7% of patients with a history of myasthenic crisis and 49.0% of those without. The median MG-ADL score was 2.0; 33.7% scored 0, while 13.9% scored ≥6. The median prednisolone dose was 5.0 mg/day; 67.2% received ≤5 mg, and 9.0% received ≥15 mg. Depending on the definition used, 1.0% to 22.8% were classified as refractory.</p><p><strong>Conclusion: </strong>This study provides real-world insights into treatment outcomes in Korean MG patients. While about half achieved stable disease with conventional therapies, a substantial proportion remained inadequately controlled, underscoring ongoing treatment challenges.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory-immune crosstalk in aneurysmal subarachnoid hemorrhage: bidirectional Mendelian randomization and causal mediation evidence.","authors":"Xinyang Yan, Liangchao Jiang, Jiachen Wang, Zheng Zhang, Yunfei Zhou, Longxiao Zhang, Zhongbo Yang, Yi Shen, Jiaxi Li, Jinning Song","doi":"10.1080/01616412.2025.2568031","DOIUrl":"https://doi.org/10.1080/01616412.2025.2568031","url":null,"abstract":"<p><strong>Background: </strong>The causal interplay between inflammatory mediators and immune cell phenotypes in aneurysmal subarachnoid hemorrhage (aSAH) remains undefined. We investigated whether immune surface antigens influence rupture risk through inflammatory protein mediation.</p><p><strong>Methods: </strong>Using European genetic consortium data, we implemented an integrated Mendelian randomization (MR) framework. First, univariable MR assessed effects of 731 immune cell traits and 91 inflammatory proteins on rupture risk. Second, two-step MR quantified mediation effects where exposures influenced both mediator and outcome. Third, multivariable MR determined direct effects after mediator adjustment. Sensitivity analyses controlled for smoking, systolic blood pressure, and lipid levels.</p><p><strong>Results: </strong>Elevated CD4 abundance on plasma CD28+ CD4+ T cells reduced rupture risk [OR (odds ratio) = 0.901; <i>p</i> = 0.004]. Serum CX3CL1 mediated 12% of this protection (OR _mediation = 0.987; two-step MR <i>p</i> < 0.05). The direct protective effect persisted after CX3CL1 adjustment (OR _direct = 0.913; multivariable MR <i>p</i> = 0.013).Separately, interleukin-7 demonstrated strong independent risk effects (OR = 2.027; <i>p</i> = 1.29×10^{- 4}, Bonferroni-corrected). Our comprehensive screen additionally identified multiple immuno-inflammatory factors significantly associated with aSAH risk (univariable MR <i>p</i><0.05), further evidencing the complex immunoinflammatory network in rupture pathogenesis. No pathway showed significant confounding by cardiometabolic factors.</p><p><strong>Conclusions: </strong>We establish a novel immune-inflammatory axis wherein CD4+ T cell surface signatures confer protection against intracranial aneurysm rupture partially through CX3CL1 downregulation, while interleukin-7 independently promotes rupture. These findings reveal actionable targets for risk stratification and immunomodulatory interventions.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxemia after thrombectomy deteriorating functional prognosis and aggravates inflammatory response in acute ischemic stroke.","authors":"Zhe Cheng, Jie Gao, Lilin Ma, Wei Xu, Muyuan Cheng, Fenghai Li, Jing Liu, Bo Pang, Yuchuan Ding, Xiaokun Geng, Zhongrong Miao","doi":"10.1080/01616412.2025.2509153","DOIUrl":"10.1080/01616412.2025.2509153","url":null,"abstract":"<p><strong>Background: </strong>Following endovascular therapy (EVT) in acute ischemic stroke (AIS), there is a discrepancy between vessel reperfusion and favorable prognosis. Hypoxemia commonly occurs during the acute phase of AIS and may exacerbate damage to the ischemic penumbra. This study aims to investigate the correlation between hypoxemia and functional prognosis after EVT, and its influence on inflammatory response.</p><p><strong>Method: </strong>A retrospective study was conducted involving patients who underwent EVT for anterior circulation AIS. Hypoxemia was defined as arterial blood oxygen pressure <80 mmHg. The propensity score matching (PSM) method was performed to match the Hypoxemia and non-Hypoxemia groups at 1:1 ratio. The primary outcome was the difference in the mRS score at 90 days. Secondary outcomes included functional independence, NIHSS, infarct volume, mortality, symptomatic intracranial hemorrhage (sICH), pneumonia, urinary infection, and seizures. Inflammatory cytokines and cell data were also collected and analyzed.</p><p><strong>Results: </strong>A total of 116 patients were analyzed. Patients with hypoxemia had worse outcomes at 90 days, evidenced by higher modified Rankin Scale (mRS) scores (3 vs. 2), lower rates of functional independence (43.1 vs. 63.7%), and larger infarct volumes. Additionally, the hypoxemia group had lower lymphocyte but higher neutrophil and monocyte counts. Inflammatory cytokine levels were significantly elevated in the hypoxemia group, includingIL22, IL-1β, IL-6, and IL-8. Logistic regression analysis identified six factors associated with functional prognosis, including ASPECTS score, age, hypoxemia, neutrophil count, lymphocyte count, and IL-1β level.</p><p><strong>Conclusion: </strong>Hypoxemia during early phases may worsen functional prognosis of AIS patients after EVT and exacerbate inflammatory response.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"960-969"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the SUA/Scr ratio and carotid plaque in patients with ischemic stroke based on gender and age: a retrospective study.","authors":"Jiawen Dong, Shiwen Zhang, Ye Wang, Xin Zou, Ting Liu, Hui Tang, Bernhard Kolberg, Jing Li, Xuemin Shi","doi":"10.1080/01616412.2025.2508876","DOIUrl":"10.1080/01616412.2025.2508876","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between carotid plaques (CAPs) and serum uric acid/serum creatinine (SUA/Scr) ratio in ischemic stroke patients.</p><p><strong>Method: </strong>A total of 12,072 patients with ischemic stroke were assigned into three groups based on the SUA/Scr tertiles: Q1 (SUA/Scr <3.843), Q2 (3.843 ≤ SUA/Scr ≤4.979), and Q3 (SUA/Scr >4.979). The 95% confidence intervals (CI) and ORs of SUA/Scr and CAPs were determined through logistic regression. Data were considered statistically at a <i>p</i> < 0.05, after FDR correction. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value SUA/Scr for CAPs.</p><p><strong>Results: </strong>The SUA/Scr ratio was significantly associated with CAPs （OR:1.060;95%CI1.024-1.098). In the analysis of SUA/Scr as a categorical variable, regression analysis revealed that participants in the Q3 group were more likely to develop CAPs than those in the Q1 group （OR:1.175;95%CI1.043-1.324）. The relationship between SUA/Scr and CAPs persisted in male respondents even after multivariate correction (OR:1.119; 95%CI1.065-1.177). However, no association was found between the two variables in female subjects (OR:1.003; 95%CI0.954-1.055). SUA/Scr was significantly associated with CAPs in young or middle-aged (<60 years) patients after correcting for variables stratified by age (OR:1.061; 95%CI1.009-1.115). However, no correlation was found between the two in older patients (≥60 years) (OR: 0.972; 95%CI0.929-1.018).</p><p><strong>Conclusion: </strong>SUA/Scr is associated with CAPs, especially in young and middle-aged men.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"951-959"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of trigeminal neuralgia in a rat model using intranasal administration of Bulleyaconitine A.","authors":"Shaozhen Hu, Ge Yao, Haihong Cheng, Haolin Wang, Yujie Ma, Zhengnan Huang, Lei Xia, Hui Yi, Yingying Xue, Shiting Li, Jun Zhong","doi":"10.1080/01616412.2025.2511085","DOIUrl":"10.1080/01616412.2025.2511085","url":null,"abstract":"<p><strong>Introduction: </strong>Trigeminal neuralgia (TN), characterized by severe facial pain triggered by mild stimuli, is challenging to treat effectively and non-invasively. Traditional treatments, including microvascular decompression and medications like carbamazepine, have limitations. This study investigates the potential of Bulleyaconitine A (BAA), an alkaloid that selectively inhibits specific sodium channels, for managing TN in a rat model via intranasal administration.</p><p><strong>Method: </strong>Adult male Sprague-Dawley rats were subjected to a Chronic Constriction Injury (CCI) of the distal infraorbital nerve to model trigeminal neuralgia (TN). BAA was administered intranasally, and pain thresholds were assessed using the von Frey filament stimulation technique. Comparative analyses involved transnasal carbamazepine administration, with a focus on optimizing BAA dosage and delivery methods, including nasal drops, gavage, and subcutaneous injection.</p><p><strong>Result: </strong>Intranasal BAA significantly increased pain thresholds in TN rats, demonstrating superior performance compared to the control group and achieving efficacy comparable to carbamazepine over a two-week period. Among various administration routes evaluated, nasal delivery was identified as the most effective.</p><p><strong>Discussion: </strong>The study shows BAA's superior efficacy compared to carbamazepine, highlighting its potential as a TTX-selective sodium channel blocker for TN. Intranasal BAA administration offers a novel, non-invasive therapeutic option. Further research on dosage forms for clinical use, such as drug-encapsulating nanoparticles or vesicles for targeted delivery in neurological disorders, is warranted.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"991-996"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of carotid plaques stability and its correlation with ischemic stroke through computed tomography angiography.","authors":"Hong Guo, Weijie Yao, Guang Lan, Kexin Li","doi":"10.1080/01616412.2025.2508865","DOIUrl":"10.1080/01616412.2025.2508865","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between carotid plaque stability characteristics and ischemic stroke risk using computed tomography angiography (CTA), with a focus on differences between embolic stroke of undetermined source (ESUS) and non-ESUS cases.</p><p><strong>Methods: </strong>This retrospective study included 173 patients with carotid plaques who underwent extracranial carotid CTA. Patients were categorized into stroke and non-stroke groups, with the stroke group further divided into ESUS and non-ESUS subgroups. Plaque features including stenosis severity, plaque type, ulceration, intraplaque hemorrhage (IPH), and lipid-rich necrotic core (LRNC) were assessed. Clinical information was also collected to examine the connection between carotid plaque characteristics and stroke risk.</p><p><strong>Results: </strong>Compared to the non-stroke group, the stroke group had a higher proportion of male patients, elevated total cholesterol levels, greater stenosis severity, along with higher frequencies of plaque ulceration, calcification, IPH, and LRNC. Also, the maximum soft and total plaque thickness were greater, while maximum hard plaque thickness was lower. Multivariate logistic regression identified male gender, stenosis severity, LRNC, and maximum soft plaque thickness as independent risk factors. Among stroke patients, the ESUS group exhibited a higher prevalence of non-stenotic plaques (stenosis <50%), along with significantly increased IPH, plaque calcification, and adventitial calcification, compared to the non-ESUS group.</p><p><strong>Conclusion: </strong>CTA-based assessment of carotid plaque features enables effective evaluation of stroke risk. Notably, vulnerable plaques with non-severe stenosis may contribute to the pathogenesis of ESUS, underscoring the need for plaque composition analysis beyond luminal narrowing.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"941-950"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfatide antibody-mediated neuropathy: an analysis of clinical characteristics and immunotherapeutic responses.","authors":"Jinglong Hu, Qi Zheng, Fanjing Zhou, Wenqian Gao, Yun Xu, Zhuo Liu, Meijuan Zhang","doi":"10.1080/01616412.2025.2509154","DOIUrl":"10.1080/01616412.2025.2509154","url":null,"abstract":"<p><strong>Background: </strong>Sulfatide antibodies, targeting glycosphingolipids linked to myelin phospholipids, play a key role in immune-mediated peripheral neuropathies. However, their clinical features and response to immunotherapy remain unclear.</p><p><strong>Methods: </strong>A retrospective analysis of 19 sulfatide antibodies-mediated neuropathy cases from Nanjing Drum Tower Hospital (July 2019 to July 2024) assessed clinical scores (MRC, INCAT, HFGS) at admission, discharge, and 3-6 months post-discharge, with detailed documentation of clinical characteristics, electromyography findings, and treatment responses.</p><p><strong>Results: </strong>A total of 19 patients were enrolled, including 10 Guillain-Barré syndrome (GBS, 53%) and 9 chronic inflammatory demyelinating polyneuropathy (CIDP, 47%) cases. All had distal limb weakness, with two patients (11%) showing central nervous system involvement. Electromyography revealed that anti-sulfatide antibody caused damage to both myelin and axons， not only in motor nerves but also in sensory nerves. Regarding treatment, 89% patients responded well to immunotherapy. However, one CIDP patient worsened with corticosteroids, and two patients died during follow-up. Compared to the sulfatide with poly-antibodies group, the sole sulfatide antibody group demonstrated more severe clinical symptoms, with lower MRC scores (<i>p</i> = 0.0140) and higher HFGS (<i>p</i> = 0.0052) and INCAT (<i>p</i> = 0.0057) scores. Consistently, the sole sulfatide antibody group presented lower nerve amplitudes (<i>p</i> = 0.0498) and conduction velocity (<i>p</i> < 0.05) as well. Interestingly, this group of patients showed greater improvement after immunotherapy (<i>p</i> < 0.05), particularly in GBS patients.</p><p><strong>Conclusion: </strong>Sulfatide antibodies may attack peripheral nerves and the brainstem. The prognosis is relatively good for most patients by immunotherapy. Patients with sole sulfatide antibody exhibited more severe symptoms and electrophysiological issues but responded better to treatment.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"970-980"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}