Association between the SUA/Scr ratio and carotid plaque in patients with ischemic stroke based on gender and age: a retrospective study.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-10-01 Epub Date: 2025-05-29 DOI:10.1080/01616412.2025.2508876

Jiawen Dong, Shiwen Zhang, Ye Wang, Xin Zou, Ting Liu, Hui Tang, Bernhard Kolberg, Jing Li, Xuemin Shi

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引用次数: 0

Abstract

Objective: To explore the association between carotid plaques (CAPs) and serum uric acid/serum creatinine (SUA/Scr) ratio in ischemic stroke patients.

Method: A total of 12,072 patients with ischemic stroke were assigned into three groups based on the SUA/Scr tertiles: Q1 (SUA/Scr <3.843), Q2 (3.843 ≤ SUA/Scr ≤4.979), and Q3 (SUA/Scr >4.979). The 95% confidence intervals (CI) and ORs of SUA/Scr and CAPs were determined through logistic regression. Data were considered statistically at a p < 0.05, after FDR correction. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value SUA/Scr for CAPs.

Results: The SUA/Scr ratio was significantly associated with CAPs （OR:1.060;95%CI1.024-1.098). In the analysis of SUA/Scr as a categorical variable, regression analysis revealed that participants in the Q3 group were more likely to develop CAPs than those in the Q1 group （OR:1.175;95%CI1.043-1.324）. The relationship between SUA/Scr and CAPs persisted in male respondents even after multivariate correction (OR:1.119; 95%CI1.065-1.177). However, no association was found between the two variables in female subjects (OR:1.003; 95%CI0.954-1.055). SUA/Scr was significantly associated with CAPs in young or middle-aged (<60 years) patients after correcting for variables stratified by age (OR:1.061; 95%CI1.009-1.115). However, no correlation was found between the two in older patients (≥60 years) (OR: 0.972; 95%CI0.929-1.018).

Conclusion: SUA/Scr is associated with CAPs, especially in young and middle-aged men.

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基于性别和年龄的缺血性脑卒中患者SUA/Scr比值与颈动脉斑块的相关性：一项回顾性研究

目的：探讨缺血性脑卒中患者颈动脉斑块（CAPs）与血清尿酸/血清肌酐（SUA/Scr）比值的关系。方法：将12072例缺血性脑卒中患者根据SUA/Scr分类分为三组：Q1 （SUA/Scr 4.979）。通过logistic回归确定SUA/Scr和CAPs的95%置信区间（CI）和or。结果：SUA/Scr比值与CAPs显著相关（OR:1.060;95%CI1.024-1.098）。在将SUA/Scr作为分类变量进行分析时，回归分析显示Q3组的参与者比Q1组的参与者更容易发生CAPs （OR:1.175;95%CI1.043-1.324）。即使在多变量校正后，SUA/Scr和CAPs之间的关系在男性被调查者中仍然存在(OR:1.119；95% ci1.065 - 1.177)。然而，在女性受试者中没有发现这两个变量之间的关联(OR:1.003；95% ci0.954 - 1.055)。结论：SUA/Scr与CAPs相关，尤其是中青年男性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.