Neurological Research最新文献

筛选
英文 中文
Moderate dietary flavonoid intake associated with lower prevalence of Parkinson's disease: data from the NHANES 2007-2010 and 2017-2018. 膳食中适量摄入类黄酮与降低帕金森病患病率相关:来自NHANES 2007-2010和2017-2018的数据
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1080/01616412.2025.2482753
Shanshan Gong, Yuchang Fei
{"title":"Moderate dietary flavonoid intake associated with lower prevalence of Parkinson's disease: data from the NHANES 2007-2010 and 2017-2018.","authors":"Shanshan Gong, Yuchang Fei","doi":"10.1080/01616412.2025.2482753","DOIUrl":"10.1080/01616412.2025.2482753","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between dietary flavonoids and the prevalence of PD.</p><p><strong>Methods: </strong>We used data from the 2007-2010 and 2017-2018 National Health and Nutrition Examination Survey (NHANES). Dietary flavonoid intake was assessed through a two-day, 24-hour dietary recall method, and PD diagnosis was ascertained by the presence of 'Anti-Parkinson agents' among the reported prescription medications. Logistic regression, subgroup, and restricted cubic spline (RCS) models were employed to analyze the connection between dietary flavonoids and PD prevalence.</p><p><strong>Results: </strong>Our study revealed a correlation between the consumption of dietary total flavonoids, flavan-3-ols, and flavonols, and PD risk. Subgroup analysis indicated a negative correlation of dietary flavan-3-ols and total flavonoids with PD risk only among non-obese participants. Furthermore, our analysis using RCS demonstrated a nonlinear association between dietary flavonoids, flavan-3-ols, flavonols, and PD prevalence. We found that the optimal intake of total flavonoids, flavan-3-ols and flavonols wase 403.65 mg/day,346 mg/day and 26.74 mg/day, respectively. Above these thresholds, the risk of developing PD is elevated.</p><p><strong>Conclusions: </strong>Our study highlights a significant association between moderate dietary intake of total flavonoids, flavan-3-ols, and flavonols, and a reduced risk of PD. Our work may provide new therapeutic ideas for the prevention and treatment of PD and provide dietary flavonoid intake recommendations for PD patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"406-419"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis. 与二硫化相关的免疫检查点基因CD276参与胶质母细胞瘤恶性表型和不良预后的形成。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.1080/01616412.2025.2476506
Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui
{"title":"Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis.","authors":"Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui","doi":"10.1080/01616412.2025.2476506","DOIUrl":"10.1080/01616412.2025.2476506","url":null,"abstract":"<p><strong>Background: </strong>Immunotherapy has promise for glioblastoma multiforme (GBM) treatment and disulfidptosis, a form of cell death involving disintegration of the actin cytoskeleton, is a potential target. The aim of the current study was to identify genes associated with disulfidptosis-related immune checkpoints in GBM and to analyze connections with malignancy.</p><p><strong>Methods: </strong>Two expression matrices from The Cancer Genome Atlas-Genotype Tissue Expression (TCGA-GTEx) and Chinese Glioma Genome Atlas (CGGA) cyber public data were utilized to analyze differentially expressed genes (DEGs) in GBM and interaction networks for DEG-coded proteins constructed with protein-protein interaction network analysis. Functional annotation was conducted to indicate DEG function. Hub genes were identified by machine-learning, using Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine Recursive Feature Elimination (SVM-RFE). Gene expression, immune cell composition and single-cell expression were assessed via bioinformatics and in vitro assays. Finally, xenograft nude mouse models were constructed for in vivo validation.</p><p><strong>Results: </strong>35 DEGs were found in the TCGA-GTEx and 13 in the CGGA databases and linked to immune regulation and GBM progression. The key gene CD276 was screened by bioinformatics methods. CD276 had higher expression in GBM tissues than in control and was higher expression in GBM strain than in normal astrocytes. In vitro CD276 knockdown reduced GBM cell malignancy. Furthermore, CD276 knockdown suppressed tumor growth in vivo.</p><p><strong>Conclusion: </strong>CD276 was the most significant hub gene involved in disulfidptosis and immune checkpoints in GBM. Anti-CD276 therapy may have promise for GBM treatment.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"319-332"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Six-spot step test under three different task conditions to assess dual-task ability in people with multiple sclerosis. 在三种不同任务条件下的六点步骤测试评估多发性硬化症患者的双重任务能力。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/01616412.2025.2480325
Özge Ertekin, Zuhal Abasıyanık, Turhan Kahraman, Seda Daştan, Serkan Özakbaş
{"title":"Six-spot step test under three different task conditions to assess dual-task ability in people with multiple sclerosis.","authors":"Özge Ertekin, Zuhal Abasıyanık, Turhan Kahraman, Seda Daştan, Serkan Özakbaş","doi":"10.1080/01616412.2025.2480325","DOIUrl":"10.1080/01616412.2025.2480325","url":null,"abstract":"<p><strong>Background: </strong>The Six-Spot Step Test (SSST) is a valid measure to assess the ability of people with multiple sclerosis (pwMS) to maintain balance whilst challenging stability during walking. This study aimed to compare the performance of three different SSST conditions in pwMS and healthy controls (HC) and to explore whether incorporating cognitive tasks into the SSST improves its discriminative capacity by increasing cognitive load.</p><p><strong>Methods: </strong>Fifty-two pwMS (median EDSS = 1.75) and 19 HC were recruited. Participants performed the SSST under three different task conditions: conventional SSST, SSST with word-list generation task (WLG), and SSST with the serial-7 backward task. The dual-task cost (DTC) was calculated for two cognitive task conditions.</p><p><strong>Results: </strong>There was a significant difference across different SSST conditions in both groups. There was also significant condition*group interaction [F (2,132) = 3.69, <i>p</i> = 0.028, η<sup>2</sup> = 0.053]. PwMS completed all SSST conditions in a longer duration compared to HC. The DTC of SSST with backward and WLG tasks was greater in the MS group than in HC. However, there was no significant differences in the number of correct answers during the dual-task conditions between pwMS and HC. All three conditions showed excellent discriminative ability between pwMS and HC (Area Under Curve value > 0.8).</p><p><strong>Significance: </strong>The SSST had the ability to discriminate between pwMS and HC in both conventional method and with secondary cognitive task. The SSST could be used to evaluate early walking and dual-task deficits even in pwMS with mild disability for future research and clinical practice.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"356-363"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone demethylase KDM6B promotes glioma cell proliferation by increasing PDGFRA expression via chromatin loop formation. 组蛋白去甲基化酶KDM6B通过染色质环的形成增加PDGFRA的表达,从而促进胶质瘤细胞的增殖。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1080/01616412.2025.2480326
Aixia Sui, Xiaoqiang Guo
{"title":"Histone demethylase KDM6B promotes glioma cell proliferation by increasing <i>PDGFRA</i> expression via chromatin loop formation.","authors":"Aixia Sui, Xiaoqiang Guo","doi":"10.1080/01616412.2025.2480326","DOIUrl":"10.1080/01616412.2025.2480326","url":null,"abstract":"<p><strong>Objectives: </strong>Changes in gene expression pattern play an essential role in promoting the process of cancer. For example, platelet-derived growth factor receptor alpha (<i>PDGFRA</i>) is overexpressed in many cancers, including gliomas. Abnormal histone methylation is a typical characteristics of glioma, and our previous studies have shown that histone lysine demethylase 6B (KDM6B) is involved in glioma development by regulating the expression of specific oncogenes. In this study, the regulatory effect and underlying mechanism of KDM6B on <i>PDGFRA</i> expression were investigated.</p><p><strong>Methods: </strong>The expression information of KDM6B and <i>PDGFRA</i> in patients with glioma was analyzed in GEPIA database. The expression or activity of KDM6B was regulated with CRISPR interference/activation (CRISPRi/a) assays, gene knockdown and specific inhibitor. Cell proliferation was determined using cell counting kit assay. Chromatin immunoprecipitation assay (ChIP) and ChIP-loop assays were used to determine the H3K27me3 status in the <i>PDGFRA</i> promoter and DNA-DNA interactions mediated by KDM6B.</p><p><strong>Results: </strong>The expression of KDM6B and <i>PDGFRA</i> expression is positively correlated in gliomas. CRISPRi/a assays indicated that KDM6B has a positive regulatory role in <i>PDGFRA</i> expression in glioma cells and can promote glioma cell proliferation. KDM6B knockdown and inhibitor assays further proved that KDM6B promotes <i>PDGFRA</i> expression. ChIP assays indicated KDM6B reduces H3K27me3 level in the <i>PDGFRA</i> promoter. The ChIP-loop assays showed KDM6B increases the formation of chromatin loops, which facilitates the proximity of enhancer and promoter.</p><p><strong>Conclusion: </strong>This study reveals a new epigenetic mechanism of <i>PDGFRA</i> overexpression in glioma cells, that is, KDM6B catalyzes the demethylation of H3K27me3 and induces chromatin loop formation to activate <i>PDGFRA</i> expression. This study is of great significance for the understanding of glioma development and the application of new treatment strategies, such as radiation therapy combined with epigenetic therapy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"364-372"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between sympathetic skin response and RR interval variation with the prognosis of Guillain-Barre syndrome patients. 交感神经皮肤反应和 RR 间期变化与格林-巴利综合征患者预后的关系。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1080/01616412.2025.2476514
Behnaz Ansari, Mahdiyeh Gholipoor Khotbesara, Keivan Basiri
{"title":"Relationship between sympathetic skin response and RR interval variation with the prognosis of Guillain-Barre syndrome patients.","authors":"Behnaz Ansari, Mahdiyeh Gholipoor Khotbesara, Keivan Basiri","doi":"10.1080/01616412.2025.2476514","DOIUrl":"10.1080/01616412.2025.2476514","url":null,"abstract":"<p><strong>Background: </strong>Guillain-Barré syndrome (GBS) is an inflammatory disorder causing severe disability and death. The sympathetic skin response (SSR) and RR interval variability are non-invasive tests that measure autonomic dysfunction. The aim of this study was to investigate the relationship of SSR and RR interval variation with prognosis in patients with GBS in Isfahan, Iran.</p><p><strong>Methods: </strong>This cross-sectional study analyzed 32 patients with GBS in Iran between 2023 and 2024. Patients underwent EMG-NCV during their hospitalization, measuring SSR and RR interval variation. Patients' GBS disability scores were calculated and recorded on the day of hospital discharge and one month after. Gender distribution, types of GBS, intubation status, length of ICU and ward stay, GBS disability scores, and plasmapheresis volume are also compared.</p><p><strong>Results: </strong>In 19 patients (59.3%), both SSR and RR interval variability were abnormal. There were no statistically significant differences between patients with and without autonomic dysfunction (AD) for the variables compared. There were no significant differences between groups with normal and abnormal SSR and between groups with normal and abnormal RR interval variation. Age and intubation status significantly affect GBS disability scores at discharge and one month after discharge, while gender does not significantly impact any outcomes. Many variables, such as age, gender, type of GBS, intubation status, and lengths of stay, do not show significant differences between the compared groups based on AD, SSR, and RR interval variability.</p><p><strong>Conclusions: </strong>The study highlights the lack of correlation between AD, SSR, and RR interval variation in patients with GBS.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"333-338"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis. 探索饮食因素对颅内动脉瘤风险的影响:来自孟德尔随机化分析的见解。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-12 DOI: 10.1080/01616412.2025.2477240
Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao
{"title":"Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.","authors":"Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao","doi":"10.1080/01616412.2025.2477240","DOIUrl":"10.1080/01616412.2025.2477240","url":null,"abstract":"<p><strong>Background: </strong>While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted.</p><p><strong>Methods: </strong>In our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties, vegetarian foods, cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases. In MR analysis, we employed multiple Mendelian randomization techniques such as MR-Egger, Inverse Variance Weighted methods and rigorously controlled the false discovery rates through the Bonferroni correction across 10 dietary exposures.</p><p><strong>Results: </strong>Our analysis identified a significant association between cooked vegetables (OR: 9.939; 95% CI: 2.066 ~ 47.822; <i>p</i> = 0.0042) and an elevated risk of intracranial aneurysms. Besides, the initial analysis suggested a statistically significant association between the dried fruit (OR: 0.385; 95%CI: 0.159 ~ 0.935; <i>p</i> = 0.0350), frequency of alcohol intake (OR: 1.419; 95% CI: 1.039 ~ 1.937; <i>p</i> = 0.0276) and the risk of intracranial aneurysms. However, this significance was not sustained after applying the Bonferroni correction for multiple testing, indicating a need for cautious interpretation despite the initially promising findings.</p><p><strong>Conclusion: </strong>This study identified a clear causal link between cooked vegetable intake and an increased risk of intracranial aneurysm, while suggesting a potential connection between the frequency of alcohol intake and the elevated risk, although this association did not reach statistical significance after multiple testing corrections.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"347-355"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term effects of various exercise training modalities on balance, gait and fatigue in patients with multiple sclerosis: a randomized controlled study. 多种运动训练方式对多发性硬化症患者平衡、步态和疲劳的长期影响:一项随机对照研究。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/01616412.2025.2481427
Hakan Polat, Serkan Usgu
{"title":"Long-term effects of various exercise training modalities on balance, gait and fatigue in patients with multiple sclerosis: a randomized controlled study.","authors":"Hakan Polat, Serkan Usgu","doi":"10.1080/01616412.2025.2481427","DOIUrl":"10.1080/01616412.2025.2481427","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the long-term effects of vestibular exercises (VE), cervical stabilization exercises (CSE) and standard balance exercises (SBE) on balance, gait and fatigue in patients with multiple sclerosis.</p><p><strong>Methods: </strong>Thirty-five patients were randomly allocated to three groups, performing different exercises three days a week for 12 weeks. Assessments were conducted at baseline, at Week 12 and at a 6-month follow-up using the Functional Reach Test (FRT), Four-Square Step Test (FSST), 2-Minute Walk Test (2MWT), Timed Up and Go (TUG) test, and Fatigue Impact Scale (FIS).</p><p><strong>Results: </strong>At 12 weeks, both CSE and VE groups improved on FRT and 2MWT, with the CSE group also experiencing improvements on FSST, TUG, and FIS (<i>p</i> < 0.05). The SBE group showed no significant changes. At 6 months, FRT, FSST, and 2MWT improvements persisted in the VE group, while the CSE group-maintained TUG and FIS gains. The VE group had superior FRT at 6 months, while the CSE group showed greater FSST improvements at 12 weeks. The VE group exhibited greater 2MWT improvements than the CSE group at 6 months, while the CSE group had better TUG results at both timepoints. Both CSE and VE groups showed greater reductions in fatigue (FIS) than the SBE group at 6 months.</p><p><strong>Discussion: </strong>VE provide long-term benefits for balance and gait speed, while CSE enhance gait endurance and postural control during training. Both modalities contribute to long-term fatigue reduction. SBE are less effective, highlighting the need for targeted interventions such as VE and CSE for sustained improvements.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"383-392"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced expression of miR-128 in peripheral blood mononuclear cells: a potent candidate diagnostic biomarker for multiple sclerosis. 外周血单核细胞中 miR-128 的表达增强:多发性硬化症的有效候选诊断生物标记物。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-05-01 Epub Date: 2025-03-23 DOI: 10.1080/01616412.2025.2481443
Hossein Akhgari, Alireza Ahmadi, Abedeh Rezaei, Ali Mohammadi, Reza Safaralizadeh
{"title":"Enhanced expression of miR-128 in peripheral blood mononuclear cells: a potent candidate diagnostic biomarker for multiple sclerosis.","authors":"Hossein Akhgari, Alireza Ahmadi, Abedeh Rezaei, Ali Mohammadi, Reza Safaralizadeh","doi":"10.1080/01616412.2025.2481443","DOIUrl":"10.1080/01616412.2025.2481443","url":null,"abstract":"<p><strong>Objectives: </strong>Millions of people worldwide, especially young adults, are affected by multiple sclerosis (MS), a demyelinating and autoimmune condition of the central nervous system (CNS). Many studies have focused on the diagnostic value of miRNAs circulating in body fluids of MS patients. Thus, this study aimed to assess the expression of miR-128 and its potential as a biomarker for MS in the Iranian population.</p><p><strong>Methods: </strong>This study recruited 85 MS patients and 30 healthy matched controls. Following the collection of blood samples, serum was isolated. RNA was then extracted, cDNA was synthesized, and miR-128 expression was measured by real-time PCR.</p><p><strong>Results: </strong>There was significant overexpression of miR-128 in MS patients in comparison with healthy controls (p-value <0.0001). In addition, there was a rather notable association between the subtypes of MS samples and the expression levels of miR-128. ROC analysis showed an AUC of 0.9111 (95%CI 0.85-0.97, p-value <0.0001) with sensitivity and specificity of 80.00% and 93.33%, respectively.</p><p><strong>Conclusion: </strong>The expression of miR-128 was significantly higher in PBMCs of MS patients in comparison with healthy controls. Additionally, miR-128 could be an excellent biomarker for MS patient diagnosis.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"393-401"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CLU polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy. 多发性硬化症患者CLU多态性和血浆聚集蛋白水平:与残疾评分、进展率和fingolimod治疗相关
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-04-27 DOI: 10.1080/01616412.2025.2497477
Osman Oğuzhan Kılıç, Semra Mungan, Şeref Demirkaya, Birsen Can Demirdöğen
{"title":"<i>CLU</i> polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy.","authors":"Osman Oğuzhan Kılıç, Semra Mungan, Şeref Demirkaya, Birsen Can Demirdöğen","doi":"10.1080/01616412.2025.2497477","DOIUrl":"https://doi.org/10.1080/01616412.2025.2497477","url":null,"abstract":"<p><strong>Objectives: </strong>Multiple sclerosis (MS) is a chronic, demyelinating disorder of the central nervous system that is widely accepted to result from a complex interplay of genetic and environmental factors. The involvement of clusterin in neurodegenerative and autoimmune diseases has been highlighted, but its role in MS remains unclear. This study aimed to investigate the association of four single nucleotide polymorphisms (SNPs) in the clusterin gene (<i>CLU</i>) with MS susceptibility.</p><p><strong>Methods: </strong>The study group consisted of 310 patients with RRMS (pwRRMS) and 310 controls. 25 treatment-naïve pwRRMS, 25 pwRRMS on fingolimod treatment and 25 controls composed a subgroup for further analysis. The genotypes of 4 <i>CLU</i> SNPs were determined using either restriction endonuclease digestion following PCR (rs11136000 & rs3087554) or the real-time PCR method using TaqMan genotyping assays (rs2279590 & rs1532278). Plasma clusterin concentration was determined by ELISA in the subgroup (<i>n</i> = 75).</p><p><strong>Results: </strong>Our results revealed that <i>CLU</i> rs3087554 C allele (<i>p</i> = .008) and TC  +  CC genotype were significantly associated with RRMS (<i>p</i> = .002). Furthermore, haplotype analysis has also shown that T-C-T-T haplotype was associated with RRMS (<i>p</i> < .001). Moreover, plasma clusterin concentrations were significantly higher in pwRRMS on fingolimod therapy compared to treatment-naïve pwRRMS and the control group. In addition, plasma clusterin concentration was increased in patients with rs11136000 & rs1532278 CC genotypes in the subgroup.</p><p><strong>Discussion: </strong>These findings suggest that <i>CLU</i> SNPs and plasma clusterin concentrations could serve as significant biomarkers at different stages of MS.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atraumatic mandibular fossa perforation: a report of two cases and literature review. 非外伤性下颌窝穿孔2例报告并文献复习。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-04-24 DOI: 10.1080/01616412.2025.2497478
Ketan Bulsara, Taylor Burch, Timothy Parke, Karishma Bulsara, David M Shafer
{"title":"Atraumatic mandibular fossa perforation: a report of two cases and literature review.","authors":"Ketan Bulsara, Taylor Burch, Timothy Parke, Karishma Bulsara, David M Shafer","doi":"10.1080/01616412.2025.2497478","DOIUrl":"https://doi.org/10.1080/01616412.2025.2497478","url":null,"abstract":"<p><strong>Introduction: </strong>Atraumatic intrusion of the mandibular condylar head into the middle cranial fossa is exceedingly rare.</p><p><strong>Methods: </strong>We report two spontaneous presentations of glenoid fossa defects with extracranial to intracranial communication in adults from a single institution in 2021. Both cases were managed operatively via collaboration between oral and maxillofacial surgery and neurosurgery. Clinical and radiologic presentations are reviewed as well as treatment strategies.</p><p><strong>Conclusion: </strong>We aim to address possible etiologies, associated risk factors, and surgical management techniques for defect repair.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信