Neurological ResearchPub Date : 2025-08-01Epub Date: 2025-05-02DOI: 10.1080/01616412.2025.2497482
Cai Han Huang, Qi Li, Li Wen, Guang Xian Wang, Dong Zhang
{"title":"Association of wall enhancement on high-resolution magnetic resonance imaging with morphology and hemodynamics in unruptured intracranial aneurysms.","authors":"Cai Han Huang, Qi Li, Li Wen, Guang Xian Wang, Dong Zhang","doi":"10.1080/01616412.2025.2497482","DOIUrl":"10.1080/01616412.2025.2497482","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationships between intracranial aneurysm (IA) wall enhancement (AWE) and aneurysm morphology and hemodynamic parameters.</p><p><strong>Methods: </strong>A total of 100 patients (112 unruptured aneurysms) were categorized by enhancement degree (significant, slight, no enhancement) and pattern (circumferential, partial, no enhancement). Morphological and AWE features were measured using enhanced high-resolution magnetic resonance images (HR-MRI). Computational fluid dynamics (CFD) was used to calculate hemodynamic parameters, including time-averaged wall shear stress (TAWSS), normalized time-averaged wall shear stress (NTAWSS), oscillatory shear index (OSI), gradient oscillatory number (GON), and relative residence time (RRT).</p><p><strong>Results: </strong>NTAWSS (<i>p</i> < 0.05), aspect ratio (AR, <i>p</i> < 0.01), and size ratio (SR, <i>p</i> < 0.01) showed significantly statistical difference among AWE groups. The significantly enhanced group had higher AR and SR and higher RRT but lower NTAWSS compared to non-enhanced and slightly enhanced groups. Enhancement ratio negatively correlated with NTAWSS (rs = -0.33, <i>p</i> < 0.001), OSI (rs = -0.28, <i>p</i> = 0.003), and positively correlated with the GON (rs = 0.22, <i>p</i> = 0.018) and RRT (rs = 0.31, <i>p</i> < 0.001) and SR (rs = 0.51, <i>p</i> < 0.001) and AR (rs = 0.48, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Aneurysmal morphological and hemodynamic features are related to the degree and extent of AWE. Unruptured IAs with more intense AWE are larger and have lower NTAWSS and higher RRT.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"710-722"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological ResearchPub Date : 2025-08-01Epub Date: 2025-05-02DOI: 10.1080/01616412.2025.2495989
Beny Rilianto, Helda, Asri C Adisasmita, Lhuri Dwianti Rahmartani, Gea Pandhita, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Ita Muharram Sari
{"title":"A simple scoring to predict symptomatic intracranial hemorrhage after stroke thrombolysis: the EGAN score.","authors":"Beny Rilianto, Helda, Asri C Adisasmita, Lhuri Dwianti Rahmartani, Gea Pandhita, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Ita Muharram Sari","doi":"10.1080/01616412.2025.2495989","DOIUrl":"10.1080/01616412.2025.2495989","url":null,"abstract":"<p><strong>Background: </strong>Symptomatic intracranial hemorrhage (sICH) after intravenous thrombolysis represents a critical and fatal complication observed in acute ischemic stroke (AIS) patients. This study aims to establish a simple scoring model to predict sICH.</p><p><strong>Methods: </strong>We retrospectively conducted a cohort study of eligible AIS patients treated with rt-PA at a tertiary comprehensive stroke center from January 2018 to December 2022. Backward stepwise multivariable logistic regression provided the final model. The point score was generated from β-coefficients. The area under the curve (AUC) of the receiver operating characteristics (ROC) and the Hosmer-Lemeshow goodness-of-fit test were used to assess the discrimination and calibration of the model. The conditional probabilities were derived based on the Bayes theorem.</p><p><strong>Results: </strong>Of the included patients, sICH occurred in 26 (3.97%) of the 655. The EGAN score consisted of an early infarct sign (10 points), baseline glucose ≥200 mg/dL (11 points), atrial fibrillation (AF) (13 points), and an NIH Stroke Scale (NIHSS) score ≥10 (12 points). With a cut-off point of 13, the EGAN score demonstrated good discrimination (0.7453 [95% CI: 0.649-0.841]), sensitivity (80.77%), and specificity (58.19%), respectively, for identifying sICH.</p><p><strong>Conclusions: </strong>This easy-to-use scoring model, based on predictors quickly obtained in clinical practices, offers a simple approach to screening for post-thrombolysis sICH and can serve as an alternative option in hospitals with limited resources for thrombolysis therapy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"647-657"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological ResearchPub Date : 2025-08-01Epub Date: 2025-04-24DOI: 10.1080/01616412.2025.2497471
Tong Wang, Jialei Zhou, Gang Chen, Xiang Xu, Haitao Shen
{"title":"SPP1 is associated with glioma malignancy and immunosuppressive regulation in 916 samples.","authors":"Tong Wang, Jialei Zhou, Gang Chen, Xiang Xu, Haitao Shen","doi":"10.1080/01616412.2025.2497471","DOIUrl":"10.1080/01616412.2025.2497471","url":null,"abstract":"<p><strong>Background: </strong>Glioma is a disease typically characterized by immunosuppression, which explains its poor prognosis. Therefore, it is urgent to elucidate new molecular mechanisms of immune-supervised escape to improve the efficacy of immunotherapy. Recent studies have identified secreted phosphoprotein 1(SPP1) as a pro-inflammatory and chemokine in macrophages that mediates crosstalk between the innate immune system and tumor cells. We aimed to detect the role of SPP1 in immunomodulation in glioma.</p><p><strong>Methods: </strong>We enrolled 916 patients from different ethnic groups, including 603 patients from The Cancer Genome Atlas (TCGA) database and 313 patients from the Chinese Glioma Genome Atlas (CGGA) database. We performed enrichment analysis and used GSVA to calculate the immune pathway and immune cell infiltration scores of SPP1.In addition, we investigated the correlation between SPP1 and immune checkpoint genes as well as inflammation-related genes.</p><p><strong>Results: </strong>The expression of SPP1 is significantly elevated in IDH wild-type gliomas and high-grade gliomas, particularly in the mesenchymal subtype, and it serves as an independent prognostic factor for overall survival (OS) in glioma patients. SPP1 influences macrophage activation, cytokine secretion, and polarization and exhibits a strong association with various lymphocytes, including T, B and NK cells. Furthermore, SPP1 is strongly correlated not only with immune checkpoint genes but also with various inflammation-related genes.</p><p><strong>Conclusion: </strong>In conclusion, SPP1 expression is tightly linked to the molecular pathology of gliomas and is highly correlated with immune checkpoints. It contributes to glioma immune evasion, positioning SPP1 as a promising new target for immunotherapy in glioma.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"666-676"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral cannabinoid formulation elevates sensory nerve conduction velocity and mitigates oxidative stress to alleviate neuropathic pain in rats.","authors":"Shruti Mathur, Kamini, Neetu Gupta, Anil G Bhansali, Rajani Mathur, Suman Kundu","doi":"10.1080/01616412.2025.2500112","DOIUrl":"10.1080/01616412.2025.2500112","url":null,"abstract":"<p><strong>Background and aim: </strong>Use of potent painkillers like opiates are limited by their abuse potential and adverse physiological effects necessitating new therapeutics for pain management. This study assessed the efficacy of oral cannabinoid formulations (F1-F4) in alleviating chronic neuropathic pain (CP) and investigated their mechanisms through thermal algesia, inflammatory and oxidative stress biomarkers, and sensory nerve conduction velocity (SNCV).</p><p><strong>Experimental procedures: </strong>A 21-day rat model of chronic constriction injury (CCI) of the sciatic nerve was used to evaluate the effects of oral cannabinoid formulations (F1: 500 mg, F2: 1000 mg, F3: 2000 mg, F4: 3000 mg) in MCT oil, with pregabalin as the reference. Male Wistar rats (35) were divided equally into seven groups, with all except the Sham group undergoing sciatic nerve ligation and receiving different formulations.On day 22, behavioral (hot plate, tail flick) and electrophysiological (sensory nerve conduction velocity, SNCV) assessments were performed. SNCV was also measured in the presence of CB1 and CB2 receptor antagonists. Additionally, blood-based markers of inflammation (TNF-α) and oxidative stress (MDA, GSH and CAT) were analysed.</p><p><strong>Results and conclusions: </strong>The vehicle group exhibited significant hyperalgesia (<i>p</i> <0.005), reduced sensory nerve conduction velocity (SNCV) (<i>p</i> <0.005) and elevated MDA and TNF-α levels, along with decreased GSH and CAT levels in both serum and sciatic nerve tissue.Among the formulations, F2 significantly improved pain latency and SNCV (<i>p</i> <0.005) compared to the vehicle group and outperformed F1, F3, F4 and pregabalin (<i>p</i> <0.05). Its effects were mediated through CB1 and CB2 receptor agonism while simultaneously reducing oxidative stress and inflammation, highlighting its potential as a promising candidate for neuropathic pain management.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"745-755"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological ResearchPub Date : 2025-08-01Epub Date: 2025-04-22DOI: 10.1080/01616412.2025.2496929
Adnan I Qureshi, Hatem Tolba, Mohammed Sulaiman Khan, Camilo R Gomez, Chun Shing Kwok
{"title":"Short-term outcomes of atrial fibrillation patients undergoing carotid stent placement or carotid endarterectomy in the United States.","authors":"Adnan I Qureshi, Hatem Tolba, Mohammed Sulaiman Khan, Camilo R Gomez, Chun Shing Kwok","doi":"10.1080/01616412.2025.2496929","DOIUrl":"10.1080/01616412.2025.2496929","url":null,"abstract":"<p><strong>Background: </strong>Patients with atrial fibrillation (AF) were excluded from the trials evaluating carotid artery stent placement (CAS) or carotid endarterectomy (CEA). We identified the prevalence of atrial fibrillation and how it might be associated with outcomes in patients with symptomatic internal carotid artery (ICA) stenosis.</p><p><strong>Methods: </strong>We analyzed the data from the National Inpatient Sample between 2016 and 2021 with stenosis of ICA who underwent CAS or CEA. We compared the end points of intra- and post-procedural cerebral infarction, hemorrhage, discharge home and death based on the presence or absence of AF. We also compared the outcomes in AF patients who had CAS with those who had CEA.</p><p><strong>Results: </strong>Atrial fibrillation was present in 3,785 (18.3%) of 20,645 patients who underwent either CAS or CEA between 2016 and 2021, while 16,860 did not have atrial fibrillation. The proportion of patients who developed acute myocardial infarction, respiratory failure, acute kidney injury, or required blood transfusion was higher in patients with atrial fibrillation among both CAS- and CEA-treated patients. There was no difference in odds of post-procedural stroke and/or death in patients with atrial fibrillation (compared with those without atrial fibrillation) who were treated with CAS (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.62-1.60, <i>p</i> = 0.98) and those treated with CEA (OR 1.09, 95% CI 0.69-1.73, <i>p</i> = 0.72 in the multivariate analysis after adjusting for potential confounders. The length of stay and hospitalization cost were significantly higher in patients with atrial fibrillation. There was no difference in post-procedural stroke and/or death (10.7% versus 8.7%, <i>p</i> = 0.41) and discharge home (32.4% versus 26.8%, <i>p</i> = 0.13) in patients with atrial fibrillation who underwent CEA compared to those who underwent CAS in propensity-matched analysis.</p><p><strong>Conclusion: </strong>One in five patients with symptomatic ICA stenosis who undergo CAS or CEA have AF. We did not identify higher risk of post-procedural stroke and/or death irrespective of the procedure, but resource utilization was higher in AF patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"658-665"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low mean platelet volume: a risk factor for increased intraoperative blood loss in degenerative lumbar surgery.","authors":"Ehsan Alimohammadi, Alireza Sadeghsalehi, Fatemeh Ranjbari, Seifollah Ghahari Ahangar, Seyed Reza Bagheri","doi":"10.1080/01616412.2025.2541292","DOIUrl":"https://doi.org/10.1080/01616412.2025.2541292","url":null,"abstract":"<p><strong>Background: </strong>Major intraoperative blood loss (MIBL) is associated with increased morbidity and poorer outcomes. This study investigates whether preoperative mean platelet volume (MPV) may serve as a predictive biomarker for MIBL in patients undergoing degenerative lumbar surgery.</p><p><strong>Methods: </strong>A retrospective review of 421 patients with lumbar degenerative disease who underwent surgery from July 2019 to July 2022 was conducted. MIBL was defined as blood loss > 1000 ml. Patients were divided into MIBL and non-MIBL groups. Potential risk factors, including MPV, were compared. The optimal MPV cutoff (10.1) was determined using ROC analysis and Youden's index. Patients were grouped into high MPV (≥10.1 fL)and low MPV ( < 10.1 fL). Logistic regression identified independent risk factors for MIBL.</p><p><strong>Results: </strong>The cohort included 192 males (45.6%) and 229 females (54.4%), with a mean age of 61.4 ± 8.6 years. MIBL occurred in 73 patients (17.3%). The MPV distribution was 37.8% ( < 10.1 fL) and 62.2% (≥10.1 fL). Logistic regression revealed that higher mean arterial pressure (OR 3.11, 95% CI 1.72-5.21, <i>p</i> < 0.001), greater number of fused levels (OR 2.73, 95% CI 1.72-4.53, <i>p</i> = 0.016), longer surgical duration (OR 1.89, 95% CI 1.43-2.89, <i>p</i> = 0.021), and lower MPV (OR 1.72, 95% CI 1.17-2.26, <i>p</i> = 0.027)were independently associated with MIBL.</p><p><strong>Conclusions: </strong>Lower MPV may indicate an increased risk of intraoperative blood loss in lumbar degenerative surgery. Monitoring MPV - a simple, cost-effective biomarker - may assist in optimizing fluid management and blood conservation strategies. However, given the retrospective nature of this study, these findings should be interpreted with caution.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MicroRNA-106a-5p alleviates chronic constriction injury-induced neuropathic pain by targeting ten-eleven translocation 2 in a rat model.","authors":"Lei Xu, Jihong Zhang, Long Wang","doi":"10.1080/01616412.2025.2538896","DOIUrl":"https://doi.org/10.1080/01616412.2025.2538896","url":null,"abstract":"<p><strong>Objectives: </strong>Neuropathic pain (NP) is pain due to lesions or diseases of the somatosensory nervous system. microRNA-106a-5p (miR-106a-5p) is correlated with multiple illness processes. To probe the molecular mechanism of miR-106a-5p acting on NP.</p><p><strong>Methods: </strong>The chronic constriction injury (CCI) rat model was applied to simulate NP in rats. RT-qPCR was utilized to detect miR-106a-5p and ten-eleven translocation methylcytosine dioxygenase 2 (TET2) levels. Dual-luciferase reporter assay and RNA immunoprecipitation (RIP) were used to validate the targeting relationship. Enzyme-linked immunosorbent assay (ELISA) was employed to monitor the inflammatory factors levels.</p><p><strong>Results: </strong>The content of miR-106a-5p in the dorsal root ganglia (DRG) and spinal cord tissue of CCI rats was reduced by approximately 0.6-fold on postoperative day 21. Meanwhile, paw withdrawal threshold (PWT) and paw retraction latency (PWL) were reduced by approximately 0.4-fold. Notably elevated TNF-α, IL-1β and IL-6 while remarkably reduced IL-10 were discovered in CCI rats. Mechanistically, TET2 levels doubled in DGR and spinal cord tissues on postoperative day 21 and negatively regulated by miR-106a-5p. miR-106a-5p overexpression increased PWT and PWT of CCI rats, which can be reversed by upregulated TET2. Moreover, up-regulated miR-106a-5p suppressed TNF-α, IL-1β and IL-6 while increasing IL-10. This was partially reversed by TET2 overexpression.</p><p><strong>Discussion: </strong>miR-106a-5p attenuates NP by negatively regulating TET2 to raise pain threshold as well as suppressing inflammatory responses in rats. By targeting miR-106a-5p, the lack of drug specificity in clinical settings will be solved.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sukwoo Hong, Yuki Shinya, Zhen Wang, Bernard R Bendok, Nobuhito Saito
{"title":"Preventive effect of postoperative Goreisan administration on symptomatic recurrence of chronic subdural hematoma: a systematic review and meta-analysis.","authors":"Sukwoo Hong, Yuki Shinya, Zhen Wang, Bernard R Bendok, Nobuhito Saito","doi":"10.1080/01616412.2025.2540944","DOIUrl":"https://doi.org/10.1080/01616412.2025.2540944","url":null,"abstract":"<p><strong>Objectives: </strong>Goreisan is a Japanese herbal medicine composed of five active ingredients and is believed to exert its effects by inhibiting various aquaporins. This systematic review and meta-analysis aim to evaluate the effectiveness of Goreisan in the postoperative management of chronic subdural hematoma (CSDH).</p><p><strong>Methods: </strong>This review was conducted in accordance with PRISMA guidelines and included studies evaluating Goreisan for the postoperative management of CSDH. PubMed, Cochrane Library, Embase, and Google Scholar were queried to identify studies that met our criteria from their inception to December 2024. Symptomatic recurrence was the primary outcome; heterogeneity was not assessed beyond this endpoint.</p><p><strong>Results: </strong>Eleven studies (five randomized controlled trials and six retrospective studies) with 9443 patients (4809 received Goreisan and 4634 did not receive Goreisan postoperatively) were included in the analyses. The symptomatic recurrence rate was significantly lower in the Goreisan group compared to the control group (276 of 4,809 patients [5.7%] vs. 345 of 4,634 [7.4%]; odds ratio, 0.69 [95% confidence interval, 0.55 to 0.86]) with I<sup>2</sup> = 13%. AEs were reported in seven studies: five studies reported no AEs related to Goreisan, while two studies reported pollakiuria (1%) and unspecified AEs (1%). An exploratory cost comparison also indicated that the cost of postoperative Goreisan ($15-18) was substantially lower than that of burr hole drainage ($694) or middle meningeal artery embolization ($1,304).</p><p><strong>Discussion: </strong>Our study demonstrated that Goreisan is effective in preventing symptomatic recurrence in postoperative CSDH cases. (PROSPERO number CRD42025645208.).</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Can Hu, Juan Deng, Yunfeng Yu, Keke Tong, Siyang Bai, Guomin Zhang, Lusha Yao
{"title":"Unveiling the causal effects of phosphatidylethanolamine (18:1_0:0) via glutamine conjugate of C<sub>6</sub>H<sub>10</sub>O<sub>2</sub> (2) and X-23648 in Parkinson's disease: insights from mediation Mendelian randomization.","authors":"Can Hu, Juan Deng, Yunfeng Yu, Keke Tong, Siyang Bai, Guomin Zhang, Lusha Yao","doi":"10.1080/01616412.2025.2536076","DOIUrl":"10.1080/01616412.2025.2536076","url":null,"abstract":"<p><strong>Objective: </strong>The effects of lipidome and its metabolites on Parkinson's disease (PD) have not been fully elucidated. This study aimed to assess the causal effects of lipidome on PD and the mediated effects of metabolites using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Datasets of the lipidome, metabolites, and PD were acquired from genome-wide association studies, and single nucleotide polymorphisms were screened according to the basic assumptions of MR. Subsequently, inverse variance weighted was used as the main tool to assess the causal effects of lipidome on PD and the mediated effects of metabolites. Finally, the MR-Egger intercept, Cochran's Q test, and leave-one-out sensitivity analysis were used to assess the horizontal pleiotropy, heterogeneity, and robustness of the results, respectively.</p><p><strong>Results: </strong>The MR analysis showed that phosphatidylethanolamine (18:1_0:0) reduced genetic susceptibility to PD by lowering glutamine conjugate of C<sub>6</sub>H<sub>10</sub>O<sub>2</sub> (2) levels (mediated proportion: 15.80%; mediated effect: -0.024, 95% confidence interval [CI] -0.046 to -0.001, <i>p</i> = 0.040) and increasing X-23648 levels (mediated proportion: 15.20%; mediated effect: -0.022, 95% CI -0.045 to -0.001, <i>p</i> = 0.030). The MR-Egger intercept showed no horizontal pleiotropy (<i>p</i> ≥ 0.05) for these results. Cochran's Q and sensitivity analyses showed that the results were not heterogeneous and were robust.</p><p><strong>Conclusion: </strong>Our findings indicate that phosphatidylethanolamine (18:1_0:0) reduces the risk of PD by regulating glutamine conjugate of C<sub>6</sub>H<sub>10</sub>O<sub>2</sub> (2) and X-23648, providing genetic insights into the pathogenesis of PD. However, these results are based on European populations and require further experimental validation.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of wake-up stroke: a systematic review and meta-analysis.","authors":"Yuting Zhao, Jia Li, Ying Zhu, Qiuxia Qian, Xiaoling Qian, Longchun Hua, Jianxun Cao, Yuxia Ma","doi":"10.1080/01616412.2025.2534517","DOIUrl":"https://doi.org/10.1080/01616412.2025.2534517","url":null,"abstract":"<p><strong>Background: </strong>Wake-up stroke (WUS) is a subgroup of ischemic stroke in which patients show no abnormality before sleep, while wake up with neurological deficits, and the prevalence varied widely across studies. To obtain a true estimate of WUS, we conducted a systematic review and meta-analysis of previously published data.</p><p><strong>Methods: </strong>PubMed, the Cochrane Library, Web of Science, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure Database (CNKI), Wanfang Database and Weipu Database (VIP) were searched from their inception through 1 April 2025 to identify population-based, observational studies that reported the prevalence of WUS.</p><p><strong>Results: </strong>The meta-analysis included 37 studies involving 196,744 individuals. The pooled prevalence of WUS was 23.1% (95% CI: 21.1%-25.1%, I<sup>2</sup> = 98.8%). The results of the subgroup analysis showed that the pooled prevalence of WUS was 22.8% (95% CI: 21%-25%) in women and 24% (95% CI: 22%-26%) in men. The pooled prevalence of WUS based on the cross-sectional studies and cohort studies, respectively, was 25.1% (95% CI: 23%-27%) and 17.4% (95% CI: 15%-20%). Based on the regional analysis, the prevalence of WUS was 25% (95% CI: 23%-27%) in Asia, 18.5% (95% CI: 14%-22%) in Europe, and 24.1% (95% CI: 18%-31%) in North America.</p><p><strong>Conclusions: </strong>The prevalence of WUS is 23.1%, with higher rates observed in men and the Asian region. Increased awareness and training among healthcare professionals are essential for early recognition, potentially improving diagnosis and management in emergency settings. Promoting education on WUS is also vital for reducing associated morbidity and mortality.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}