SPP1 is associated with glioma malignancy and immunosuppressive regulation in 916 samples.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-04-24 DOI:10.1080/01616412.2025.2497471

Tong Wang, Jialei Zhou, Gang Chen, Xiang Xu, Haitao Shen

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引用次数: 0

Abstract

Background: Glioma is a disease typically characterized by immunosuppression, which explains its poor prognosis. Therefore, it is urgent to elucidate new molecular mechanisms of immune-supervised escape to improve the efficacy of immunotherapy. Recent studies have identified secreted phosphoprotein 1(SPP1) as a pro-inflammatory and chemokine in macrophages that mediates crosstalk between the innate immune system and tumor cells. We aimed to detect the role of SPP1 in immunomodulation in glioma.

Methods: We enrolled 916 patients from different ethnic groups, including 603 patients from The Cancer Genome Atlas (TCGA) database and 313 patients from the Chinese Glioma Genome Atlas (CGGA) database. We performed enrichment analysis and used GSVA to calculate the immune pathway and immune cell infiltration scores of SPP1.In addition, we investigated the correlation between SPP1 and immune checkpoint genes as well as inflammation-related genes.

Results: The expression of SPP1 is significantly elevated in IDH wild-type gliomas and high-grade gliomas, particularly in the mesenchymal subtype, and it serves as an independent prognostic factor for overall survival (OS) in glioma patients. SPP1 influences macrophage activation, cytokine secretion, and polarization and exhibits a strong association with various lymphocytes, including T, B and NK cells. Furthermore, SPP1 is strongly correlated not only with immune checkpoint genes but also with various inflammation-related genes.

Conclusion: In conclusion, SPP1 expression is tightly linked to the molecular pathology of gliomas and is highly correlated with immune checkpoints. It contributes to glioma immune evasion, positioning SPP1 as a promising new target for immunotherapy in glioma.

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在916个样本中，SPP1与胶质瘤恶性和免疫抑制调节有关。

背景：神经胶质瘤是一种典型的以免疫抑制为特征的疾病，这解释了其预后差的原因。因此，迫切需要阐明免疫监督逃逸的新分子机制，以提高免疫治疗的疗效。最近的研究发现，分泌磷酸化蛋白1（SPP1）在巨噬细胞中是一种促炎和趋化因子，介导先天免疫系统和肿瘤细胞之间的串扰。我们的目的是检测SPP1在胶质瘤免疫调节中的作用。方法：本研究纳入916例不同种族的患者，其中603例来自癌症基因组图谱（TCGA）数据库，313例来自中国胶质瘤基因组图谱（CGGA）数据库。我们进行富集分析，并利用GSVA计算SPP1的免疫通路和免疫细胞浸润评分。此外，我们还研究了SPP1与免疫检查点基因以及炎症相关基因的相关性。结果：SPP1在IDH野生型胶质瘤和高级别胶质瘤中表达显著升高，特别是在间充质亚型中，SPP1是胶质瘤患者总生存期（OS）的独立预后因素。SPP1影响巨噬细胞活化、细胞因子分泌和极化，并与包括T、B和NK细胞在内的多种淋巴细胞密切相关。此外，SPP1不仅与免疫检查点基因密切相关，还与多种炎症相关基因密切相关。结论：综上所述，SPP1的表达与胶质瘤的分子病理密切相关，且与免疫检查点高度相关。它有助于胶质瘤免疫逃避，使SPP1成为胶质瘤免疫治疗的一个有希望的新靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.