Neurological Research最新文献_第9页

Performance of antisaccades in patients with cerebral small vessel disease accompanied by white matter hyperintensities. 伴有白质高密度症的脑小血管疾病患者的反斜视表现。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-18 DOI: 10.1080/01616412.2024.2367934

Huimin Fan, Jing Feng, Yuchuan Ding, Pan Gu, Liying Wang, Xiaomeng Chen, Xiaokun Geng

{"title":"Performance of antisaccades in patients with cerebral small vessel disease accompanied by white matter hyperintensities.","authors":"Huimin Fan, Jing Feng, Yuchuan Ding, Pan Gu, Liying Wang, Xiaomeng Chen, Xiaokun Geng","doi":"10.1080/01616412.2024.2367934","DOIUrl":"10.1080/01616412.2024.2367934","url":null,"abstract":"Objectives: The antisaccades (AS) task is considered a reliable indicator of inhibitory control of eye movements in humans. Achieving good AS performance requires efficient cognitive processes that are sensitive to changes in brain structure. White matter hyperintensities (WMH) can cause subcortical-cortical dysconnectivity, affecting diverse cognitive domains. Thus, the AS task was investigated in patients with WMH in cerebral small vessel disease (CSVD).Methods: In this retrospective study, 75 participants with WMH, determined by neuroimaging standards for CSVD research, were admitted to the Department of Neurology of Beijing Luhe Hospital, Capital Medical University from January 2021 to December 2022. All subjects underwent the AS task, Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and 3.0T brain MRI. Additionally, 61 healthy subjects were recruited to characterize WMH profiles.Results: Compared to the control group, patients with WMH had a significantly increased AS error rate (49.81%, p = 0.001) and lower gain (76.00%, p = 0.042). The AS error rate was significantly higher in patients with WMH in the frontal lobe than in those without WMH (p = 0.004). After adjusting for confounders (age), a positive correlation was found between the AS error rate and MoCA scores for patients with WMH (coefficient = 0.262, p = 0.024).Conclusions: Patients with WMH due to CSVD exhibited abnormal AS performances, particularly in the frontal lobe. The eye movement paradigms, the new diagnostic forms in neurology, can be utilized to investigate the distributed cortical and subcortical systems involved in cognitive control processes, offering simple, well-tolerated and highly sensitive advantages over traditional measures.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"917-924"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and diagnostic delay in cluster headache in Egypt. 埃及丛集性头痛的临床特征和诊断延误。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-27 DOI: 10.1080/01616412.2024.2367936

Mona Af Nada, Salsabil Abo Al-Azayem, Mona K Moawad

{"title":"Clinical characteristics and diagnostic delay in cluster headache in Egypt.","authors":"Mona Af Nada, Salsabil Abo Al-Azayem, Mona K Moawad","doi":"10.1080/01616412.2024.2367936","DOIUrl":"10.1080/01616412.2024.2367936","url":null,"abstract":"Background: Early diagnosis of CH is a cornerstone and it is important to detect causes leading to diagnostic delay. Limited published data exist regarding CH in Egypt, and with no data showing characteristics of CH or causes of diagnostic delay .Aim: To investigate clinical characteristics, for CH and detect causes of diagnostic delay in Egypt.Methodology: A cross-sectional study was conducted including all patients (age: 18-60 years) with primary headache disorders in Egypt with CH patients consecutively recruited over 1 year. Demographic and clinical characteristics as well as rate of diagnostic delay were collected.Results: This registry included 1187 patients with primary headaches over a year. CH accounted for 1.9% . The majority of CH patients were males (82%), and a mean age of 37.9 ± 10 years. The mean age of disease onset was 25 ± 8 years. Sixty-five percent had episodic CH, while 34.8% had chronic CH. Most of the patients (95.7%) had strictly unilateral pain (right side 52.2%, left side 43.5%). Autonomic features were rhinorrhea (91%), ptosis (87%), and lacrimation (78%). Migrainous features were found in 26% of patients. Bout duration of CH lasted on an average of 1-4 months. Time interval of diagnostic delay ranged from 0.5 to 29 years, with a mean diagnostic delay of 9.8 ± 7.9 years.Conclusion: This study showed that CHs present 1.9% of primary headache disorders in Egypt, with males more affected than females. the incidence of smoking was higher among CH patients. Marked diagnostic delay was found which necessitate an action toward raising awareness.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"925-932"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting postoperative delirium after percutaneous transluminal angioplasty and stenting in patients with intracranial atherosclerotic stenosis. 颅内动脉粥样硬化性狭窄患者经皮腔内血管成形术和支架植入术后谵妄的预测。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-23 DOI: 10.1080/01616412.2024.2370730

Wanchun Zhu, Yiman Shen, Hua Zhao, Yinda Tang, Xuhui Wang, Shiting Li

{"title":"Predicting postoperative delirium after percutaneous transluminal angioplasty and stenting in patients with intracranial atherosclerotic stenosis.","authors":"Wanchun Zhu, Yiman Shen, Hua Zhao, Yinda Tang, Xuhui Wang, Shiting Li","doi":"10.1080/01616412.2024.2370730","DOIUrl":"10.1080/01616412.2024.2370730","url":null,"abstract":"Objective: Known as a major surgical complication, postoperative delirium (POD) has not been well studied in patients with intracranial atherosclerotic stenosis (ICAS). This study aimed to investigate the correlation between perioperative clinical characteristics and the occurrence of POD.Methods: Patients' demographic characteristics and perioperative testing data were collected. Binary logistic regression was conducted for assessing related risk factors. A nomogram was developed to predict the occurrence of POD after percutaneous transluminal angioplasty and stenting (PTAS) in patients with ICAS.Results: The occurrence of POD in this study was 30.67%. Among all the clinical and laboratory characteristics in patients, age (OR = 1.234, 95%CI = 1.004-1.517, p = 0.046), gender (OR = 5.676, 95%CI = 1.028-31.334, p = 0.046), preoperative MMSE scores (OR = 2.298, 95%CI = 1.005-5.259, p = 0.049), the degree of stenosis (OR = 6.294, 95%CI = 1.043-37.974, p = 0.045), operating time (OR = 1.088, 95%CI = 1.023-1.157, p = 0.006), and HbA1c levels (OR = 2.226, 95%CI = 1.199-4.130, p = 0.011) were the independent risk factors.Conclusion: Male patients with advanced-age, lower preoperative MMSE scores, severe stenosis, longer operating time, and higher HbA1c levels are closely related to POD after PTAS. Fully perioperative assessments may play an important role in predicting the occurrence of POD.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"956-964"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The additive effect between bupropion and citicoline upon induction of anti-nociceptive effect in nerve-ligated mice. 安非他酮和柠檬胆碱在诱导神经绑定小鼠抗痛觉效应时的相加效应。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-03 DOI: 10.1080/01616412.2024.2370203

Nastaran Raissi-Dehkordi, Bardia Hajikarimloo, Negar Raissi-Dehkordi, Fatemeh Khakpai, Mohammad-Reza Zarrindast

{"title":"The additive effect between bupropion and citicoline upon induction of anti-nociceptive effect in nerve-ligated mice.","authors":"Nastaran Raissi-Dehkordi, Bardia Hajikarimloo, Negar Raissi-Dehkordi, Fatemeh Khakpai, Mohammad-Reza Zarrindast","doi":"10.1080/01616412.2024.2370203","DOIUrl":"10.1080/01616412.2024.2370203","url":null,"abstract":"Objectives: Bupropion is an atypical antidepressant that shows robust efficacy in the regulation of neuropathic pain. Citicoline is a dietary supplement which is used as a neuroprotective agent for central nervous system (CNS) disorders. The probable interaction between bupropion and citicoline on neuropathic pain was assessed in male mice.Methods: Neuropathic pain was induced by sciatic nerve ligation. Neuropathic pain was examined in nerve-ligated mice using tail-flick and hot-plate tests.Results: The results indicated that intraperitoneal (i.p.) administration of citicoline (50 and 100 mg/kg) induced an anti-nociceptive effect in nerve-ligated animals. Similarly, i.p. injection of bupropion (2.5 and 5 mg/kg) induced anti-nociceptive effects in nerve-ligated mice. Co-administration of different doses of bupropion (2.5 and 5 mg/kg) along with a low dose of citicoline (25 mg/kg) caused an anti-nociceptive effect by enhancement of tail-flick and hot plate latencies. Interestingly, there is an additive effect between bupropion and citicoline upon the induction of the anti-nociceptive effect.Conclusions: Based on these results, it can be concluded that there is an interaction between bupropion and citicoline upon induction of an anti-nociceptive effect in nerve-ligated mice.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"939-946"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of ferroptosis on the in vitro OGD/R model in rat microglia. 铁蛋白沉积对大鼠小胶质细胞体外 OGD/R 模型的影响

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-16 DOI: 10.1080/01616412.2024.2370205

Tao Ye, Ning Zhang, Anbang Zhang, Xiuqi Sun, Bo Pang, Xuemei Wu

{"title":"The influence of ferroptosis on the in vitro OGD/R model in rat microglia.","authors":"Tao Ye, Ning Zhang, Anbang Zhang, Xiuqi Sun, Bo Pang, Xuemei Wu","doi":"10.1080/01616412.2024.2370205","DOIUrl":"10.1080/01616412.2024.2370205","url":null,"abstract":"Objective: We aimed to explore the influence of ferroptosis on an oxygen-glucose deprivation/reoxygenation (OGD/R) model in primary rat microglia.Methods: Primary microglia were extracted from rats and cultured in vitro. The cells were subjected to a hypoxic environment for 6 h in a glucose-free medium, and then re-oxygenated for 24 h in DMEM/F12. Rat microglia were pretreated with the ferroptosis activator erastin and the ferroptosis inhibitor ferrostatin 1 for 24 h, followed by detection of cell cycle progression and apoptosis by flow cytometry. Intracellular total iron levels were measured. In addition, the relative levels of reactive oxygen species (ROS), malondialdehyde (MDA), and superoxide dismutase (SOD) were determined using enzyme-linked immunosorbent assay. The protein levels of 15-lox2, GPX4, SLC7A11, ACSL4, and TFR1 were examined by western blotting.Results: Compared with rat microglia subjected to OGD/R, pretreatment with erastin did not influence cell apoptosis but significantly enhanced total iron levels, MDA, and ROS levels, whereas it reduced SOD levels. Moreover, it upregulated ACSL4, TFR1, and 15-lox2 and downregulated GPX4 and SLC7A11. Pretreatment with ferrostatin 1 significantly inhibited cell apoptosis and cell cycle arrest in the G0/G1 phase. It significantly reduced total iron levels, MDA, and ROS levels and enhanced SOD levels, which also downregulated ACSL4, TFR1, and 15-lox2, and upregulated GPX4 and SLC7A11.Conclusion: Our study showed that inhibition of ferroptosis is favorable against potential OGD/R-induced damage in rat microglia.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"947-955"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resection of meningiomas located in motor eloquent areas - comparative analysis of navigated transcranial magnetic stimulation and conventional neuronavigation. 位于运动区的脑膜瘤切除术--导航经颅磁刺激与传统神经导航的比较分析。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-02 DOI: 10.1080/01616412.2024.2370731

Thomas Eibl, Michael Schrey, Jakob Rossmann, Adrian Liebert, Leonard Ritter, Rüdiger Lange, Hans-Herbert Steiner, Karl-Michael Schebesch

{"title":"Resection of meningiomas located in motor eloquent areas - comparative analysis of navigated transcranial magnetic stimulation and conventional neuronavigation.","authors":"Thomas Eibl, Michael Schrey, Jakob Rossmann, Adrian Liebert, Leonard Ritter, Rüdiger Lange, Hans-Herbert Steiner, Karl-Michael Schebesch","doi":"10.1080/01616412.2024.2370731","DOIUrl":"10.1080/01616412.2024.2370731","url":null,"abstract":"Background: Navigated transcranial magnetic stimulation (nTMS) has been established as a preoperative diagnostic procedure in glioma surgery, increasing the extent of resection and preserving functional outcome. nTMS motor mapping for the resection of motor eloquent meningiomas has not been evaluated in a comparative analysis, yet.Methods: We conducted a retrospective matched-pair analysis for tumor location and size in meningioma patients with tumors located over or close to the primary motor cortex. Half of the study population received nTMS motor mapping preoperatively (nTMS-group). The primary endpoint were permanent surgery-related motor deficits. Additional factors associated with new motor deficits were evaluated apart from nTMS.Results: 62 patients (mean age 62 ± 15.8 years) were evaluated. 31 patients received preoperative nTMS motor mapping. In this group, motor thresholds (rMT) corresponded with tumor location and preoperative motor status, but could not predict motor outcome. No patient with preoperative intact motor function had a surgery-related permanent deficit in the nTMS group whereas four patients in the non-TMS group with preoperative intact motor status harbored from permanent deficits. 13 patients (21.3%) had a permanent motor deficit postoperatively with no difference between the nTMS and the non-TMS-group. Worsening in motor function was associated with higher patient age (p = 0.01) and contact to the superior sagittal sinus (p = 0.027).Conclusion: nTMSmotor mapping did not lead to postoperative preservation in motorfunction. nTMS data corresponded well with the preoperative motorstatus and were associated with postoperative permanent deficits if tumors were located over the motor hotspot according to nTMS.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"965-971"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stroke in Qatar: a decade of insights from a national registry. 卡塔尔的脑卒中：全国登记册十年来的启示。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-06 DOI: 10.1080/01616412.2024.2363092

Ahmad A Abujaber, Yahia Imam, Abdulqadir Nashwan, Ahmed M Own, Naveed Akhtar

{"title":"Stroke in Qatar: a decade of insights from a national registry.","authors":"Ahmad A Abujaber, Yahia Imam, Abdulqadir Nashwan, Ahmed M Own, Naveed Akhtar","doi":"10.1080/01616412.2024.2363092","DOIUrl":"10.1080/01616412.2024.2363092","url":null,"abstract":"Background: Stroke is a major cause of death and disability worldwide and presents a significant burden on healthcare systems. This retrospective study aims to analyze the characteristics and outcomes of stroke patients admitted to Hamad General Hospital (HGH) stroke service in Qatar from January 2014 to July 2022.Methods: The medical records of 15,859 patients admitted during the study period were analyzed. The data collected included patient demographics, stroke types, admission location, procedures performed, mortality rates, and other clinical characteristics.Results: Of the total cohort, 70.9% were diagnosed with a stroke, and 29.1% were diagnosed with stroke mimics. Of the stroke patients, 85.3% had an ischemic stroke, and 14.7% had a hemorrhagic stroke. Male patients below 65 years old (80.2%) and of South Asian ethnicity (44.6%) were the most affected. The mortality rate was 4.6%, significantly higher for hemorrhagic stroke than ischemic stroke (12.6% vs. 3.2%). Female patients had a higher stroke-related mortality rate than male patients (6.8% vs. 4%). The thrombolysis rate was 9.5%, and the thrombectomy rate was 3.4% of the ischemic stroke cohort. The mean door-to-needle time for thrombolysis was 61.2 minutes, and the mean door-to-groin time for thrombectomy was 170 minutes. Stroke outcomes were good, with 59.3% of patients having favorable outcomes upon discharge (mRS ≤2), which improved to 68.2% 90 days after discharge.Conclusion: This study provides valuable insights into stroke characteristics and outcomes in Qatar. The findings suggest that stroke mortality rates are low, and favorable long-term disability outcomes are achievable. However, the study identified a higher stroke-related mortality rate among female patients and areas for improvement in thrombolysis and thrombectomy time.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"893-906"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum cholesterol levels and Parkinson's disease: a detailed investigation in Turkish population. 血清胆固醇水平与帕金森病：对土耳其人群的详细调查。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1080/01616412.2024.2390193

Esma Kobak Tur, Buse Cagla Ari

{"title":"Serum cholesterol levels and Parkinson's disease: a detailed investigation in Turkish population.","authors":"Esma Kobak Tur, Buse Cagla Ari","doi":"10.1080/01616412.2024.2390193","DOIUrl":"10.1080/01616412.2024.2390193","url":null,"abstract":"Objectives: Parkinson's disease (PD) involves the progressive loss of dopaminergic neurons and the accumulation of α-synuclein. Elevated cholesterol levels may exacerbate α-synuclein aggregation, potentially contributing to PD. This study investigates the link between lipid profiles and PD severity, as well as cognitive functions in patients, aiming to inform pathogenesis and management strategies.Methods: Data from 250 PD patients and 100 healthy controls were analyzed. Serum cholesterol levels were compared with disease severity using Unified Parkinson's Disease Rating Scale (UPDRS) and modified Hoehn & Yahr Rating Scale (mH&Y). Mini-Mental State Examination (MMSE) assessed cognitive functions.Results: Of the participants, 45.4% were female, 54.6% male, with a mean age of 69.09 ± 11.13 years. Mean UPDRS score was 52.34 ± 26.32, mH&Y was 2.28 ± 0.91. Patients had significantly higher HDL levels (47.92 ± 11.63) than controls (45.40 ± 13.89) (p = 0.024). HDL levels were significantly higher in patients with cognitive impairment than in patients with cognitive normal (p = 0.004). On the contrary, triglyceride levels were significantly lower in those with cognitive impairment compared to those with cognitively normal (p = 0.005). Multivariate logistic regression showed being male associated with 3.796 times higher risk of illness, and HDL is associated with 1.030 times increased illness risk.Conclusion: High HDL levels and male gender particularly increase the risk of Parkinson's disease. Additionally, HDL and triglyceride levels affect the cognition of PD patients. Further studies on the impact of cholesterol metabolism on the pathogenesis of PD could contribute to identifying effective treatment targets.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"982-988"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of nylon, vicryl, and fibrin glue for nerve grafting in rats. 尼龙、Vicryl 和纤维蛋白胶用于大鼠神经移植的比较。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI: 10.1080/01616412.2024.2376307

Amgad S Hanna, Ethan Mickelson, Ahmed H Omar, Matthew Baer, Jacob Sveum, Taylor Marti, Raveena Mishra, Melissa Trudrung, Jacob Hutchinson, Pradeep Attaluri, Alison Jacobs, Emily Ott, Natalie Martinson, Jalon Jones, Daniel Hellenbrand

{"title":"Comparison of nylon, vicryl, and fibrin glue for nerve grafting in rats.","authors":"Amgad S Hanna, Ethan Mickelson, Ahmed H Omar, Matthew Baer, Jacob Sveum, Taylor Marti, Raveena Mishra, Melissa Trudrung, Jacob Hutchinson, Pradeep Attaluri, Alison Jacobs, Emily Ott, Natalie Martinson, Jalon Jones, Daniel Hellenbrand","doi":"10.1080/01616412.2024.2376307","DOIUrl":"10.1080/01616412.2024.2376307","url":null,"abstract":"Objectives: For nerve injuries, not amendable to tensionless epineural coaptation of the nerve, autografts are the preferred treatment. Although absorbable sutures are not recommended for nerve repair, there is no evidence that non-absorbable sutures are superior to absorbable sutures. This study aims to assess the effectiveness of non-absorbable monofilament nylon sutures, absorbable monofilament vicryl sutures, and fibrin glue when used for nerve grafting.Methods: Lewis rats (N = 32) were subjected to a sciatic nerve transection and randomly assigned to a group: graft with Nylon, graft with Vicryl, graft with Fibrin Glue, or no graft. Motor function, sensory function, and thermal pain were assessed during a 12-week recovery period, and immunohistochemistry was used to assess macrophage response.Results: At 12 weeks, the Vicryl and Nylon groups had significantly larger ankle angles at to lift off, which is a measure of motor function, compared to injured controls (p < 0.05). Grafted rats displayed no difference in thermal response but hypersensitivity to mechanical stimuli compared to the uninjured hindlimb. The Nylon, Vicryl, and Fibrin Glue groups all had significantly less atrophy of the gastrocnemius muscle compared to injured controls (p < 0.0001). In the Fibrin Glue group, 3/9 grafts did not incorporate. The Nylon group had significantly less (p = 0.0004) axon growth surrounding the suture holes compared to the Vicryl group. There were no differences in the axon counts, motor neurons, or sensory neurons between all grafted rats.Conclusions: These results demonstrate that vicryl sutures work just as well as nylon for nerve recovery after injury and grafting.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"972-981"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examination time-distance characteristics of gait and pelvic kinematics in individuals with Diabetic polyneuropathy: a case-control study. 糖尿病多发性神经病患者步态和骨盆运动学的时间-距离特征：一项病例对照研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-25 DOI: 10.1080/01616412.2024.2367938

Büşra Kalkan Balak, Bahar Anaforoglu

{"title":"Examination time-distance characteristics of gait and pelvic kinematics in individuals with Diabetic polyneuropathy: a case-control study.","authors":"Büşra Kalkan Balak, Bahar Anaforoglu","doi":"10.1080/01616412.2024.2367938","DOIUrl":"10.1080/01616412.2024.2367938","url":null,"abstract":"Background: Diabetic Peripheral Neuropathy (DPN) disrupts body and movement biomechanics, increases mechanical stress during walking, and predisposes individuals to injuries owing to the repetitive effects of these stresses.Aims: This study aimed to assess and compare the impact of neuropathy on gait and pelvic kinematics in individuals with DPN.Methods: This case-control study included two groups: 23 individuals diagnosed with DPN aged between 35-70 and 23 healthy individuals aged-35-70. The BTS-G, a wireless motion sensor, was used to assess the time-distance characteristics of walking in all participants. The system analyzed data pertaining to walking speed, cadence, percentages of stance and swing phases, durations of walking cycles, double-step lengths, pelvic tilt, obliquity, and rotation symmetries.Results: There were no statistically significant differences between the groups in cadence, left and right stance phase percentages, or left and right swing phase percentages (p > 0.05). However, significant differences were observed between the groups in terms of speed, left and right walking cycle durations, and left and right double-step lengths (p < 0.05). Additionally, no statistically significant difference was found between the groups in pelvic tilt symmetry and left and right pelvic tilt range of motion values (p > 0.05). Nevertheless, significant differences were identified between the groups in pelvic obliquity symmetry, pelvic rotation symmetry, left and right pelvic obliquity range of motion, and left and right pelvic rotation range of motion values (p < 0.05).Conclusions: The findings of this study suggest that individuals with DPN exhibit decreased walking speed, prolonged gait cycle duration, increased double step length, and reduced pelvic obliquity and rotation range of motion.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"933-938"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0