Neurological ResearchPub Date : 2024-05-01Epub Date: 2024-04-01DOI: 10.1080/01616412.2024.2328486
Hüseyin Doğu, Anas Abdallah
{"title":"A novel guide device for pedicle screw insertion using three-dimensional preoperative planning in open lumbar spinal surgery: a comparative retrospective study.","authors":"Hüseyin Doğu, Anas Abdallah","doi":"10.1080/01616412.2024.2328486","DOIUrl":"10.1080/01616412.2024.2328486","url":null,"abstract":"<p><strong>Objective: </strong>Pedicle screw stabilization (PSS) surgeries for spinal instability are still the most effective treatment approach. The use of preoperative planning can minimize the complications related to transpedicular screw (TPS) misplacement. The study aimed to evaluate the surgical outcomes of a guide device developed to improve the accuracy of the free-hand technique using three-dimensional planning in PSS.</p><p><strong>Patients and methods: </strong>Patients with degenerative spinal diseases who underwent open PSS between 2019 and 2022 were evaluated retrospectively. FG group included patients who were operated on using the fluoroscopy alone with preoperative two-dimensional planning. AFG group included patients who were operated on using a guide advice-assisted technique with preoperative 3DP. Between-group comparisons were performed.</p><p><strong>Results: </strong>A total of 143 patients with a mean age of 59.6 years were included in the study. 71 patients were assessed in the FG group and 72 patients in the AFG group. Between-group comparisons regarding demographics, etiologies, radiation exposure, and functional improvements showed no significant differences (<i>p</i> > 0.05). Although the accuracy of TPSs positioning was 94.2% and 96.5% in the 2DG and 3DG, the difference between the groups was not statistically significant. The statistically significant differences regarding the upper-level facet joint violation and pedicle breach rates were lower in the AFG group (<i>p</i> < 0.0001; X<sup>2</sup> = 19.57) and (<i>p</i> < 0.0001; X<sup>2</sup> = 25.3), respectively.</p><p><strong>Conclusion: </strong>Using a guide device associated with preoperative 3PD reduced the upper-level facet joint violation and pedicle breach rates in open PSS surgeries performed by free-hand technique for degenerative spinal diseases.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"426-436"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-stroke dizziness, depression and anxiety.","authors":"Pan Gu, Yuchuan Ding, Mangal Ruchi, Jing Feng, Huimin Fan, Aminan Fayyaz, Xiaokun Geng","doi":"10.1080/01616412.2024.2328490","DOIUrl":"10.1080/01616412.2024.2328490","url":null,"abstract":"<p><strong>Objective: </strong>Vestibular and psychiatric disorders are very closely related. Previous research shows that the discomfort and dysfunction caused by dizziness in patients can affect psychological processes, leading to anxiety and depression, and the irritation of anxiety and depression can aggravate the discomfort of dizziness. But the causal relationship between dizziness in the recovery period of stroke and Post-stroke depression (PSD) / Post-stroke anxiety (PSA) is not clear. Identifying the causal relationship between them can enable us to conduct more targeted treatments.</p><p><strong>Methods: </strong>We review the epidemiology and relationship of dizziness, anxiety, and depression, along with the related neuroanatomical basis. We also review the pathophysiology of dizziness after stroke, vestibular function of patients experiencing dizziness, and the causes and mechanisms of PSD and PSA. We attempt to explore the possible relationship between post-stroke dizziness and PSD and PSA.</p><p><strong>Conclusion: </strong>The treatment approach for post-stroke dizziness depends on its underlying cause. If the dizziness is a result of PSD and PSA, addressing these psychological factors may alleviate the dizziness. This can be achieved through targeted treatments for PSD and PSA, such as psychotherapy, antidepressants, or anxiolytics, which could indirectly improve dizziness symptoms. Conversely, if PSA and PSD are secondary to vestibular dysfunction caused by stroke, a thorough vestibular function assessment is crucial. Identifying the extent of vestibular impairment allows for tailored interventions. These could include vestibular rehabilitation therapy and medication aimed at vestibular restoration. By improving vestibular function, secondary symptoms like anxiety and depression may also be mitigated.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"466-478"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological ResearchPub Date : 2024-05-01Epub Date: 2024-03-18DOI: 10.1080/01616412.2024.2325312
Roine El-Habta, Sara Af Bjerkén, Ana Virel
{"title":"<i>N</i>-acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase.","authors":"Roine El-Habta, Sara Af Bjerkén, Ana Virel","doi":"10.1080/01616412.2024.2325312","DOIUrl":"10.1080/01616412.2024.2325312","url":null,"abstract":"<p><strong>Objectives: </strong>Current treatments for Parkinson's disease using pharmacological approaches alleviate motor symptoms but do not prevent neuronal loss or dysregulation of dopamine neurotransmission. In this article, we have explored the molecular mechanisms underlying the neuroprotective effect of the antioxidant <i>N</i>-acetylcysteine (NAC) on the damaged dopamine system.</p><p><strong>Methods: </strong>SH-SY5Y cells were differentiated towards a dopaminergic phenotype and exposed to 6-hydroxydopamine (6-OHDA) to establish an <i>in vitro</i> model of Parkinson's disease. We examined the potential of NAC to restore the pathological effects of 6-OHDA on cell survival, dopamine synthesis as well as on key proteins regulating dopamine metabolism. Specifically, we evaluated gene- and protein expression of tyrosine hydroxylase (TH), vesicle monoamine transporter 2 (VMAT2), and α-synuclein, by using qPCR and Western blot techniques. Moreover, we quantified the effect of NAC on total dopamine levels using a dopamine ELISA assay.</p><p><strong>Results: </strong>Our results indicate that NAC has a neuroprotective role in SH-SY5Y cells exposed to 6-OHDA by maintaining cell proliferation and decreasing apoptosis. Additionally, we demonstrated that NAC treatment increases dopamine release and protects SH-SY5Y cells against 6-OHDA dysregulations on the proteins TH, VMAT2, and α-synuclein.</p><p><strong>Conclusions: </strong>Our findings contribute to the validation of compounds capable to restore dopamine homeostasis and shed light on the metabolic pathways that could be targeted to normalize dopamine turnover. Furthermore, our results highlight the effectiveness of the antioxidant NAC in the prevention of dopaminergic neurodegeneration in the present model.</p><p><strong>Abbreviations: </strong>DAT, dopamine transporter; 6-OHDA, 6-hydroxydopamine; NAC, N-acetylcysteine; PARP, poly (ADP-ribose) polymerase; RA; retinoic acid; ROS, reactive oxygen species; TH, tyrosine hydroxylase; TPA, 12-O-tetradecanoyl-phorbol-13-acetate; VMAT2, vesicle monoamine transporter 2.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"406-415"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological ResearchPub Date : 2024-05-01Epub Date: 2024-02-28DOI: 10.1080/01616412.2024.2323335
Anthony V Nguyen, Jose M Soto, Biai D Digbeu, Christine Y Nguyen, Erxi Wu, Jason H Huang, Yong-Fang Kuo
{"title":"Factors associated with longer survival among older medicare patients after diagnosis of supratentorial primary brain malignancies: a retrospective cohort study.","authors":"Anthony V Nguyen, Jose M Soto, Biai D Digbeu, Christine Y Nguyen, Erxi Wu, Jason H Huang, Yong-Fang Kuo","doi":"10.1080/01616412.2024.2323335","DOIUrl":"10.1080/01616412.2024.2323335","url":null,"abstract":"<p><strong>Objectives: </strong>Despite recent advances, the prognosis for primary malignant brain tumors (PMBTs) remains poor. Some commonly prescribed medications may exhibit anti-tumor properties in various cancers, and neurodegenerative diseases may activate pathways that counteract gliomagenesis. Our study is focused on determining if there is a correlation between the use of metformin, beta-blockers, angiotensin converting enzyme inhibitors (ACEIs), and angiotensin receptor blockers (ARBs), or the presence of Parkinson's disease (PD), and the survival rates following a diagnosis of a PMBT.</p><p><strong>Methods: </strong>This analysis of the 100% Texas Medicare Database identified patients aged 66+ years diagnosed with a supratentorial PMBT from 2014-2017. Cox proportional hazards regression was employed to analyze survival following diagnosis and associations of survival with surgical intervention, radiation, PD diagnosis, and prescription of metformin, beta-blockers, ACEIs, or ARBs.</p><p><strong>Results: </strong>There were 1,943 patients who met study criteria, and the median age was 74 years. When medication utilization was stratified by none, pre-diagnosis only, post-diagnosis only, or both pre- and post-diagnosis (continuous), continuous utilization of metformin, beta-blockers, ACEIs, or ARBs was associated with prolonged survival compared to no utilization (hazard ratio [HR]:0.45, 95% CI:0.33-0.62; HR:0.71. 95% CI:0.59-0.86; HR:0.59, 95% CI:0.48-0.72; and HR:0.45, 95% CI:0.35-0.58 respectively). PD was also associated with longer survival (HR:0.59-0.63 across the four models).</p><p><strong>Discussion: </strong>Our study suggests that metformin, beta-blockers, ACEIs, ARBs, and comorbid PD are associated with a survival benefit among geriatric Medicare patients with supratentorial PMBTs.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"379-390"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurological ResearchPub Date : 2024-05-01Epub Date: 2024-03-11DOI: 10.1080/01616412.2024.2328493
Mohammed Maan Al-Salihi, Mohammed Rahman, Maryam Sabah Al-Jebur, Yezan Al-Salihi, Omar Shihadeh, Firas Hammadi, Ali Ayyad
{"title":"Effect of preservation versus resection of turbinate on olfactory function in endoscopic trans-nasal trans-sphenoidal pituitary surgery: a systematic review and meta-analysis.","authors":"Mohammed Maan Al-Salihi, Mohammed Rahman, Maryam Sabah Al-Jebur, Yezan Al-Salihi, Omar Shihadeh, Firas Hammadi, Ali Ayyad","doi":"10.1080/01616412.2024.2328493","DOIUrl":"10.1080/01616412.2024.2328493","url":null,"abstract":"<p><strong>Background: </strong>Utilizing endoscopes in surgery offers advantages and concerns, including potential nasal function impacts. Hyposmia following Transseptal Transsphenoidal hypophysectomy ranges from 0% to 2.2%. Debates persist about managing the M.T. in endoscopic sinus surgery due to its impact on nasal function. While preservation is recommended for sinonasal health, debates continue, as certain cases require resection. Our meta-analysis aims to compare turbinate resection and preservation effects on olfactory function.</p><p><strong>Methods: </strong>We searched five electronic databases to collect all relevant studies. Records were screened for eligibility. Data were extracted from the included studies independently. Our continuous outcomes were pooled as standardized mean difference with 95% CI. Statistical analyses was done by RevMan.</p><p><strong>Results: </strong>Our meta-analysis included four studies involving 235 patients (81 males). Evaluating changes in olfaction scores, two one-month studies (82 patients) revealed no significant difference between preservation and resection groups (Std.MD = 0.05[-0.39, 0.50], <i>p</i> = 0.81). For three-month assessments (146 patients), SNOT tests indicated no significant difference (Std.MD = 0.21, 95% CI[-0.11, 0.54], <i>p</i> = 0.20). Two studies used other tests on 70 patients at three months, yielding no significant difference (Std.MD = 0.13, 95% CI [-0.35, 0.62], <i>p</i> = 0.59). Two six-month studies (72 patients) similarly found no significant difference (Std.MD = 0.09, 95% CI [-0.39, 0.56], <i>p</i> = 0.72).</p><p><strong>Conclusion: </strong>Our meta-analysis involving 235 patients examined olfaction score changes over various time frames in trans-nasal trans-sphenoidal pituitary surgeries. No significant differences were observed between turbinate preservation and resection groups at one month, three months, or six months post-surgery.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"444-452"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Focality in childhood absence epilepsy","authors":"Özlem Yayıcı Köken, Boran Şekeroğlu, Burçin Şanlıdağ, Mehpare Sarı Yanartaş, Arzu Yılmaz","doi":"10.1080/01616412.2024.2339114","DOIUrl":"https://doi.org/10.1080/01616412.2024.2339114","url":null,"abstract":"Childhood absence epilepsy (CAE) has a typical electroencephalography (EEG) pattern of generalized 3 Hz spike and wave discharges (SWD). Focal interictal discharges were also documented in a small ...","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":"137 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140635260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatiana M. Alekseeva, Maria P. Topuzova, Vladimir P. Kulikov, Pavel D. Kovzelev, Mark G. Kosenko, Pavel P. Tregub
{"title":"Hypercapnic hypoxia as a rehabilitation method for patients after ischemic stroke","authors":"Tatiana M. Alekseeva, Maria P. Topuzova, Vladimir P. Kulikov, Pavel D. Kovzelev, Mark G. Kosenko, Pavel P. Tregub","doi":"10.1080/01616412.2024.2343510","DOIUrl":"https://doi.org/10.1080/01616412.2024.2343510","url":null,"abstract":"Experimental studies on animals have demonstrated a higher neuroprotective efficacy of hypercapnic hypoxia compared to normocapnic hypoxia. Respiratory training with hypercapnic hypoxia has shown a...","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":"9 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140625323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suellen Marinho Andrade, Clébya Candeia de Oliveira Marques, Larissa Coutinho de Lucena, Karina Vieira da Costa, Irinaldo Capitulino de Souza, Camila Beatriz da Silva Machado, Maria Eduarda Bezerra Sales Queiroz, Larissa Pereira Costa, Stephano Tomaz da Silva
{"title":"Effect of transcranial direct current stimulation and transcranial magnetic stimulation on the cognitive function of individuals with Alzheimer’s disease: a systematic review with meta-analysis and meta-regression","authors":"Suellen Marinho Andrade, Clébya Candeia de Oliveira Marques, Larissa Coutinho de Lucena, Karina Vieira da Costa, Irinaldo Capitulino de Souza, Camila Beatriz da Silva Machado, Maria Eduarda Bezerra Sales Queiroz, Larissa Pereira Costa, Stephano Tomaz da Silva","doi":"10.1080/01616412.2024.2321779","DOIUrl":"https://doi.org/10.1080/01616412.2024.2321779","url":null,"abstract":"To analyze the effects of transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) on the cognitive function of individuals with Alzheimer’s disease (AD).This syst...","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":"440 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140608864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet Selim Gel, Ayhan Kanat, Demet Seker, Hakan Koc, Iskender Samet Daltaban, Huseyin Findik, Omer Lutfi Gundogdu
{"title":"Changes in retinal nerve fiber layer thickness may be the cause of post-COVID-19 headaches","authors":"Mehmet Selim Gel, Ayhan Kanat, Demet Seker, Hakan Koc, Iskender Samet Daltaban, Huseyin Findik, Omer Lutfi Gundogdu","doi":"10.1080/01616412.2024.2340875","DOIUrl":"https://doi.org/10.1080/01616412.2024.2340875","url":null,"abstract":"The prevalence of post-COVID headaches is not low. The eye can be affected by this infection, but it is not clear yet what the relationship is between persistent headaches and the thickness of the ...","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":"45 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140600106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie Bustros, Manmeet Kaur, Elizabeth Ritchey, Jerzy P Szaflarski, Gerald Jr McGwin, Kristen O. Riley, J. Nicole Bentley, Adeel A. Memon, Zeenat Jaisani
{"title":"Non-lesional epilepsy does not necessarily convey poor outcomes after invasive monitoring followed by resection or thermal ablation","authors":"Stephanie Bustros, Manmeet Kaur, Elizabeth Ritchey, Jerzy P Szaflarski, Gerald Jr McGwin, Kristen O. Riley, J. Nicole Bentley, Adeel A. Memon, Zeenat Jaisani","doi":"10.1080/01616412.2024.2340879","DOIUrl":"https://doi.org/10.1080/01616412.2024.2340879","url":null,"abstract":"We aimed to compare outcomes including seizure-free status at the last follow-up in adult patients with medically refractory focal epilepsy identified as lesional vs. non-lesional based on their ma...","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":"423-425 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}