Neurological Research最新文献_第9页

Nitroglycerin attenuates ischemic neuronal injury via PKG-dependent regulation of endoplasmic reticulum (ER) stress and glucose metabolism. 硝酸甘油通过pkg依赖性调节内质网应激和葡萄糖代谢来减轻缺血性神经元损伤。

IF 1.5 4区医学

Neurological Research Pub Date : 2025-08-07 DOI: 10.1080/01616412.2025.2537899

Hongrui Wang, Shangqian Jiang, Yuchuan Ding, Leticia Simo, Xiaokun Geng

{"title":"Nitroglycerin attenuates ischemic neuronal injury via PKG-dependent regulation of endoplasmic reticulum (ER) stress and glucose metabolism.","authors":"Hongrui Wang, Shangqian Jiang, Yuchuan Ding, Leticia Simo, Xiaokun Geng","doi":"10.1080/01616412.2025.2537899","DOIUrl":"https://doi.org/10.1080/01616412.2025.2537899","url":null,"abstract":"Background: Nitroglycerin (GTN), a widely used anti-anginal drug, has emerged as a potential alternative therapy for acute ischemic stroke. However, the underlying protective mechanisms of GTN in neuronal ischemic injury remain unclear. This study investigates the neuroprotective effects of GTN on glucose metabolism and endoplasmic reticulum (ER) stress during oxygen-glucose deprivation followed by reoxygenation (OGD/R).Methods: Primary rat cortical neurons were subjected to 2 hours of OGD, followed by either 6 or 24 hours of reoxygenation (OGD/R) or no reoxygenation (OGD only). GTN was administered at reoxygenation onset or at the end of the OGD. The PKG inhibitor KT5823 was administered at the onset of OGD. Cell viability and neuronal apoptosis were assessed using CCK-8 assays, TUNEL staining, and Western blotting. Reactive oxygen species (ROS), lactate, and cyclic guanosine monophosphate (cGMP) levels were measured via ELISA, and nitric oxide (NO) levels were determined using the Griess method. ER stress-related proteins, glycolytic/gluconeogenic enzymes, and signaling molecules were analyzed by qRT-PCR and Western blotting.Results: GTN significantly improved neuronal survival, preserved cell integrity, and reduced apoptosis under OGD/R conditions. It restored ROS, lactate, NO, and cGMP levels, but not in the OGD-only group. GTN markedly reduced glycolytic enzymes, gluconeogenic enzymes, and ERS-related proteins. It also enhanced PKG expression while suppressing phosphorylated AMPK, effects observed only under OGD/R conditions. The neuroprotective effects of GTN were abolished by the PKG inhibitor KT5823.Conclusion: GTN confers neuroprotection in OGD/R injury by activating PKG signaling, alleviating ER stress, and modulating glucose metabolism by suppressing hyperglycolysis and gluconeogenesis.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic efficacy of multimodal MRI combined with ICAM-1 for cognitive impairment after intracerebral hemorrhage. 多模态MRI联合ICAM-1对脑出血后认知功能障碍的诊断价值。

IF 1.5 4区医学

Neurological Research Pub Date : 2025-08-06 DOI: 10.1080/01616412.2025.2536073

Hongxiang Fu, Lixin Luo, Li Chen

{"title":"Diagnostic efficacy of multimodal MRI combined with ICAM-1 for cognitive impairment after intracerebral hemorrhage.","authors":"Hongxiang Fu, Lixin Luo, Li Chen","doi":"10.1080/01616412.2025.2536073","DOIUrl":"https://doi.org/10.1080/01616412.2025.2536073","url":null,"abstract":"Objective: We aimed to investigate the diagnostic value of multimodal magnetic resonance imaging (MRI) combined with intercellular adhesion molecule-1 (ICAM-1) in detecting cognitive impairment (CI) after intracerebral hemorrhage (ICH).Methods: Clinical data were collected from 130 patients with ICH, all of whom received brain MRI to assess imaging characteristics, including white matter lesion (WML) scores, the number of cerebral microbleeds (CMBs), fractional anisotropy (FA) values, and apparent diffusion coefficients. Serum ICAM-1 levels were detected. At a 3-month follow-up, patients were classified into a CI group (n = 57) and an non-CI group (n = 73) according to Montreal Cognitive Assessment. The diagnostic value of multimodal MRI parameters and ICAM-1 levels was analyzed. Logistic regression analysis was performed to identify independent predictors of CI after ICH.Results: Patients in the CI group were older and had a higher prevalence of hypertension than the non-CI group. They also exhibited higher WML scores, greater CMB counts, and elevated serum ICAM-1 level, and lower FA values in the basal ganglia, parietal lobe, and frontotemporal regions. The combination of multimodal MRI parameters with ICAM-1 levels showed superior diagnostic accuracy compared to individual indicators. Logistic regression identified hypertension, WML score, basal ganglia FA value, parietal lone FA value, and ICAM-1 levels were independent factors of CI after ICH.Conclusion: Multimodal MRI parameters and serum ICAM-1 levels have high diagnostic value for identifying CI after ICH. Hypertension, WML score, reduced FA value in specific brain regions, and elevated ICAM-1 levels are closely associated with CI after ICH.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celastrol treatment attenuates the inflammatory response in Alzheimer's disease model mice. 雷公藤红素治疗可减轻阿尔茨海默病模型小鼠的炎症反应。

IF 1.5 4区医学

Neurological Research Pub Date : 2025-08-05 DOI: 10.1080/01616412.2025.2534077

Fanfan Cao, Pan Zhang, Zelun Zheng, Ping Wang, Ying Wang, Qin Shi, Denghai Zhang, Limin Xu

引用次数: 0

Relationship between cerebrospinal fluid catecholamines levels and biomarkers of Alzheimer's disease, inflammation and neuronal injury. 脑脊液儿茶酚胺水平与阿尔茨海默病、炎症和神经元损伤生物标志物的关系

IF 1.5 4区医学

Neurological Research Pub Date : 2025-08-03 DOI: 10.1080/01616412.2025.2542944

Isabel Portela Moreira, Paula Serrão, Lucinda Sequeira, Maria José Sá, Maria Augusta Vieira-Coelho, Joana Guimarães

{"title":"Relationship between cerebrospinal fluid catecholamines levels and biomarkers of Alzheimer's disease, inflammation and neuronal injury.","authors":"Isabel Portela Moreira, Paula Serrão, Lucinda Sequeira, Maria José Sá, Maria Augusta Vieira-Coelho, Joana Guimarães","doi":"10.1080/01616412.2025.2542944","DOIUrl":"10.1080/01616412.2025.2542944","url":null,"abstract":"Objectives: Changes in the locus coeruleus are among the earliest events in Alzheimer's disease (AD). We aimed to evaluate the relationship between cerebrospinal fluid (CSF) L-dihydroxyphenylalanine (L-DOPA), dopamine, and norepinephrine with CSF biomarkers of AD pathology (β-amyloid and p-tau), neuronal destruction (neurofilaments), and inflammation (leukocytes, IgG index, interleukin-6 and 10).Methods: We conducted a cross-sectional, observational study, including 35 patients with AD, 16 with frontotemporal dementia, and 38 normal controls (NC).Results: L-DOPA was lower (p = 0.032) and neurofilaments were higher (p = 0.005) in AD than in NC. Norepinephrine levels were positively correlated with age (r = 0.260, p = 0.015 among all patients). L-DOPA levels were negatively correlated with neurofilaments (r = -0.228, p = 0.038 among all participants). Interleukin-6 was positively correlated with L-DOPA (r = 0.382, p = 0.026) and norepinephrine (r = 0.485, p = 0.004) levels in AD.Conclusion: Since neurofilaments are associated with neuronal damage, decreased L-DOPA levels in AD could be related to neuronal destruction. Catecholaminergic dysregulation seen in AD seems independent of β-amyloid and p-tau pathology.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Alzheimer's disease susceptibility genes by the integration of genomics and transcriptomics. 结合基因组学和转录组学鉴定阿尔茨海默病易感基因。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-07 DOI: 10.1080/01616412.2025.2499890

Chenghong OuYang, Hanping Shi, Zhiying Lin

{"title":"Identification of Alzheimer's disease susceptibility genes by the integration of genomics and transcriptomics.","authors":"Chenghong OuYang, Hanping Shi, Zhiying Lin","doi":"10.1080/01616412.2025.2499890","DOIUrl":"10.1080/01616412.2025.2499890","url":null,"abstract":"Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease. With the deepening of clinical and genomic research, a series of biomarkers and risk factors related to AD have been identified. However, the exact molecular mechanism of AD is not completely understood.Methods: By combining expression quantitative trait loci (eQTLs) analysis with the results of genome-wide association studies (GWAS), the candidate genes (CG) related to AD were screened out accurately. We identified that intersection genes of differentially expressed genes (DEGs) and CG are the key genes. Then, GO, KEGG, and GSEA were utilized for functional enrichment analysis. Finally, we predicted AD responses to immunotherapy by the single sample gene set enrichment analysis (ssGSEA).Results: A total of 253 DEGs were identified. The three key genes (VASP, SURF2, and TARBP1) were identified by taking the intersection of DEGs and CG. Through Mendelian randomization (MR) analysis, it was found that the risk of AD was significantly increased when VASP expression increased (OR = 0.1.046), while the risk of AD was significantly decreased when SURF2 (OR = 0.897) and TARBP1(OR = 0.920) expression increased. Subsequently, the functional analysis indicated that the core genes were mainly enriched in Leukocyte Transendothelial Migration, cGMP-PKG signaling pathway, and Rap1 signaling pathway. Through ssGSEA analysis showed that all three core genes were significantly related to M2 macrophages.Conclusions: Three core genes were screened by integrating eQTLs data, GWAS data and transfer group data, and the potential mechanism of diagnosis and treatment of AD was revealed.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"732-744"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of topically applied sodium-2-mercaptoethanesulfonate (MESNA) in the prevention of epidural fibrosis following lumbar laminectomy in rats. 局部应用2-巯基乙磺酸钠（MESNA）预防大鼠腰椎椎板切除术后硬膜外纤维化的作用。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1080/01616412.2025.2498688

Erdal Resit Yilmaz, Ekrem Yalcin, Ata Turker Arikok, Muhammed Erkan Emrahoglu, Habibullah Olgun, Eylem Eren Eyupoglu, Askin Esen Hasturk

{"title":"Effects of topically applied sodium-2-mercaptoethanesulfonate (MESNA) in the prevention of epidural fibrosis following lumbar laminectomy in rats.","authors":"Erdal Resit Yilmaz, Ekrem Yalcin, Ata Turker Arikok, Muhammed Erkan Emrahoglu, Habibullah Olgun, Eylem Eren Eyupoglu, Askin Esen Hasturk","doi":"10.1080/01616412.2025.2498688","DOIUrl":"10.1080/01616412.2025.2498688","url":null,"abstract":"Objective: In spinal surgery practices through which nervous tissues are released as a result of decompression, the occurrence of fibrosis is a substantial issue that reduces the success rates. This study investigated the positive impacts of topical application of sodium-2-mercaptoethanesulfonate (MESNA) on the prevention of fibrosis at the surgical site.Material and methods: All groups were anesthetized 4 weeks after the procedure, and they were subjected to neuromonitoring. Subsequently, after the rats were killed, the development of fibrosis was evaluated in a macroscopic manner by creating a surgical site through the previous incision. The left L4 root was excised along with its peripheral tissue, and the prevalence of the fibrosis was evaluated microscopically.Results: The fibrous tissue was observed to be less prevalent in the group where MESNA was applied, as per the macroscopic and histopathologic scoring.Conclusion: The positive macroscopic and microscopic effectiveness of the topically applied MESNA solution to prevent fibrosis was demonstrated. Further research is needed to substantiate this potential of MESNA.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"723-731"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atraumatic mandibular fossa perforation: a report of two cases and literature review. 非外伤性下颌窝穿孔2例报告并文献复习。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-04-24 DOI: 10.1080/01616412.2025.2497478

Ketan Bulsara, Taylor Burch, Timothy Parke, Karishma Bulsara, David M Shafer

引用次数: 0

Bioethics of neurotechnologies: a field in effervescence. 神经技术的生命伦理学：一个沸腾的领域。

IF 1.5 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-23 DOI: 10.1080/01616412.2025.2499896

Robert A Moumdjian

引用次数: 0

Effect of pain-related sodium channels SCN9A and SCN10A polymorphisms in migraine chronification. 疼痛相关钠通道SCN9A和SCN10A多态性在偏头痛慢性化中的作用。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-10 DOI: 10.1080/01616412.2025.2497480

Erhan Kilic, Ceyda Colakoglu- Bergel, Isil Ezgi Eryilmaz, Emel Oguz-Akarsu, Unal Egeli, Cigdem Sevda Erer-Ozbek, Deniz Sigirli, Rumeysa Fatma Balaban, Ebrucan Bulut, Gulsah Cecener, Mehmet Zarifoglu, Hamdi Necdet Karli

{"title":"Effect of pain-related sodium channels SCN9A and SCN10A polymorphisms in migraine chronification.","authors":"Erhan Kilic, Ceyda Colakoglu- Bergel, Isil Ezgi Eryilmaz, Emel Oguz-Akarsu, Unal Egeli, Cigdem Sevda Erer-Ozbek, Deniz Sigirli, Rumeysa Fatma Balaban, Ebrucan Bulut, Gulsah Cecener, Mehmet Zarifoglu, Hamdi Necdet Karli","doi":"10.1080/01616412.2025.2497480","DOIUrl":"10.1080/01616412.2025.2497480","url":null,"abstract":"Objective: Based on the frequency of attacks, migraine is classified into two subtypes: episodic (EM) and chronic (CM). Migraine progression from EM to CM is supposed to be affected by various factors, which is known as \"migraine chronification. However, the pathophysiology of migraine chronification is multifactorial and still not fully understood. Ion channels are hypothesized to play a role in migraine pathophysiology and are essential for generating and suppressing action potentials, which lie under the pain and related symptoms. Two sodium channel genes, SCN9A and SCN10A, have been reported to be associated with various pain sensitivities. Studies have shown that patients with EM and CM are more sensitive to chronic pain and that pain sensitivity may be a risk factor for chronification. Thus, the current study aimed to determine whether pain sensitivity-related SCN9A and SCN10A polymorphisms affect the EM-to-CM transition.Methods: For this purpose, genotyping was performed using TaqMan SNP Assay for the (i) SCN9A rs7595255, rs12622743, and rs11898284, (ii) SCN10A rs6795970, rs6801957 SNPs in Turkish EM and CM patients.Results: The results showed that SCN9A and SCN10A polymorphisms did not play a role in the development of chronicity. However, the results indicated that the SCN10A rs6795970 polymorphism was associated with osmophobia (p = 0.036).Conclusion: SCN10A rs6795970 polymorphism may be necessary to predict the EM-to-CM transition and identify therapeutic targets. However, further studies are required to confirm the osmophobia association of the SCN10A rs6795970 polymorphism and to investigate the role of these SNPs in chronification.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"698-709"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLU polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy. 多发性硬化症患者CLU多态性和血浆聚集蛋白水平：与残疾评分、进展率和fingolimod治疗相关

IF 1.7 4区医学

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-04-27 DOI: 10.1080/01616412.2025.2497477

Osman Oğuzhan Kılıç, Semra Mungan, Şeref Demirkaya, Birsen Can Demirdöğen

{"title":"CLU polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy.","authors":"Osman Oğuzhan Kılıç, Semra Mungan, Şeref Demirkaya, Birsen Can Demirdöğen","doi":"10.1080/01616412.2025.2497477","DOIUrl":"10.1080/01616412.2025.2497477","url":null,"abstract":"Objectives: Multiple sclerosis (MS) is a chronic, demyelinating disorder of the central nervous system that is widely accepted to result from a complex interplay of genetic and environmental factors. The involvement of clusterin in neurodegenerative and autoimmune diseases has been highlighted, but its role in MS remains unclear. This study aimed to investigate the association of four single nucleotide polymorphisms (SNPs) in the clusterin gene (CLU) with MS susceptibility.Methods: The study group consisted of 310 patients with RRMS (pwRRMS) and 310 controls. 25 treatment-naïve pwRRMS, 25 pwRRMS on fingolimod treatment and 25 controls composed a subgroup for further analysis. The genotypes of 4 CLU SNPs were determined using either restriction endonuclease digestion following PCR (rs11136000 & rs3087554) or the real-time PCR method using TaqMan genotyping assays (rs2279590 & rs1532278). Plasma clusterin concentration was determined by ELISA in the subgroup (n = 75).Results: Our results revealed that CLU rs3087554 C allele (p = .008) and TC + CC genotype were significantly associated with RRMS (p = .002). Furthermore, haplotype analysis has also shown that T-C-T-T haplotype was associated with RRMS (p < .001). Moreover, plasma clusterin concentrations were significantly higher in pwRRMS on fingolimod therapy compared to treatment-naïve pwRRMS and the control group. In addition, plasma clusterin concentration was increased in patients with rs11136000 & rs1532278 CC genotypes in the subgroup.Discussion: These findings suggest that CLU SNPs and plasma clusterin concentrations could serve as significant biomarkers at different stages of MS.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"677-691"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0