Neurological Research最新文献_第9页

Stroke in Qatar: a decade of insights from a national registry. 卡塔尔的脑卒中：全国登记册十年来的启示。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-06 DOI: 10.1080/01616412.2024.2363092

Ahmad A Abujaber, Yahia Imam, Abdulqadir Nashwan, Ahmed M Own, Naveed Akhtar

{"title":"Stroke in Qatar: a decade of insights from a national registry.","authors":"Ahmad A Abujaber, Yahia Imam, Abdulqadir Nashwan, Ahmed M Own, Naveed Akhtar","doi":"10.1080/01616412.2024.2363092","DOIUrl":"10.1080/01616412.2024.2363092","url":null,"abstract":"Background: Stroke is a major cause of death and disability worldwide and presents a significant burden on healthcare systems. This retrospective study aims to analyze the characteristics and outcomes of stroke patients admitted to Hamad General Hospital (HGH) stroke service in Qatar from January 2014 to July 2022.Methods: The medical records of 15,859 patients admitted during the study period were analyzed. The data collected included patient demographics, stroke types, admission location, procedures performed, mortality rates, and other clinical characteristics.Results: Of the total cohort, 70.9% were diagnosed with a stroke, and 29.1% were diagnosed with stroke mimics. Of the stroke patients, 85.3% had an ischemic stroke, and 14.7% had a hemorrhagic stroke. Male patients below 65 years old (80.2%) and of South Asian ethnicity (44.6%) were the most affected. The mortality rate was 4.6%, significantly higher for hemorrhagic stroke than ischemic stroke (12.6% vs. 3.2%). Female patients had a higher stroke-related mortality rate than male patients (6.8% vs. 4%). The thrombolysis rate was 9.5%, and the thrombectomy rate was 3.4% of the ischemic stroke cohort. The mean door-to-needle time for thrombolysis was 61.2 minutes, and the mean door-to-groin time for thrombectomy was 170 minutes. Stroke outcomes were good, with 59.3% of patients having favorable outcomes upon discharge (mRS ≤2), which improved to 68.2% 90 days after discharge.Conclusion: This study provides valuable insights into stroke characteristics and outcomes in Qatar. The findings suggest that stroke mortality rates are low, and favorable long-term disability outcomes are achievable. However, the study identified a higher stroke-related mortality rate among female patients and areas for improvement in thrombolysis and thrombectomy time.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"893-906"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum cholesterol levels and Parkinson's disease: a detailed investigation in Turkish population. 血清胆固醇水平与帕金森病：对土耳其人群的详细调查。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1080/01616412.2024.2390193

Esma Kobak Tur, Buse Cagla Ari

{"title":"Serum cholesterol levels and Parkinson's disease: a detailed investigation in Turkish population.","authors":"Esma Kobak Tur, Buse Cagla Ari","doi":"10.1080/01616412.2024.2390193","DOIUrl":"10.1080/01616412.2024.2390193","url":null,"abstract":"Objectives: Parkinson's disease (PD) involves the progressive loss of dopaminergic neurons and the accumulation of α-synuclein. Elevated cholesterol levels may exacerbate α-synuclein aggregation, potentially contributing to PD. This study investigates the link between lipid profiles and PD severity, as well as cognitive functions in patients, aiming to inform pathogenesis and management strategies.Methods: Data from 250 PD patients and 100 healthy controls were analyzed. Serum cholesterol levels were compared with disease severity using Unified Parkinson's Disease Rating Scale (UPDRS) and modified Hoehn & Yahr Rating Scale (mH&Y). Mini-Mental State Examination (MMSE) assessed cognitive functions.Results: Of the participants, 45.4% were female, 54.6% male, with a mean age of 69.09 ± 11.13 years. Mean UPDRS score was 52.34 ± 26.32, mH&Y was 2.28 ± 0.91. Patients had significantly higher HDL levels (47.92 ± 11.63) than controls (45.40 ± 13.89) (p = 0.024). HDL levels were significantly higher in patients with cognitive impairment than in patients with cognitive normal (p = 0.004). On the contrary, triglyceride levels were significantly lower in those with cognitive impairment compared to those with cognitively normal (p = 0.005). Multivariate logistic regression showed being male associated with 3.796 times higher risk of illness, and HDL is associated with 1.030 times increased illness risk.Conclusion: High HDL levels and male gender particularly increase the risk of Parkinson's disease. Additionally, HDL and triglyceride levels affect the cognition of PD patients. Further studies on the impact of cholesterol metabolism on the pathogenesis of PD could contribute to identifying effective treatment targets.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"982-988"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of nylon, vicryl, and fibrin glue for nerve grafting in rats. 尼龙、Vicryl 和纤维蛋白胶用于大鼠神经移植的比较。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI: 10.1080/01616412.2024.2376307

Amgad S Hanna, Ethan Mickelson, Ahmed H Omar, Matthew Baer, Jacob Sveum, Taylor Marti, Raveena Mishra, Melissa Trudrung, Jacob Hutchinson, Pradeep Attaluri, Alison Jacobs, Emily Ott, Natalie Martinson, Jalon Jones, Daniel Hellenbrand

{"title":"Comparison of nylon, vicryl, and fibrin glue for nerve grafting in rats.","authors":"Amgad S Hanna, Ethan Mickelson, Ahmed H Omar, Matthew Baer, Jacob Sveum, Taylor Marti, Raveena Mishra, Melissa Trudrung, Jacob Hutchinson, Pradeep Attaluri, Alison Jacobs, Emily Ott, Natalie Martinson, Jalon Jones, Daniel Hellenbrand","doi":"10.1080/01616412.2024.2376307","DOIUrl":"10.1080/01616412.2024.2376307","url":null,"abstract":"Objectives: For nerve injuries, not amendable to tensionless epineural coaptation of the nerve, autografts are the preferred treatment. Although absorbable sutures are not recommended for nerve repair, there is no evidence that non-absorbable sutures are superior to absorbable sutures. This study aims to assess the effectiveness of non-absorbable monofilament nylon sutures, absorbable monofilament vicryl sutures, and fibrin glue when used for nerve grafting.Methods: Lewis rats (N = 32) were subjected to a sciatic nerve transection and randomly assigned to a group: graft with Nylon, graft with Vicryl, graft with Fibrin Glue, or no graft. Motor function, sensory function, and thermal pain were assessed during a 12-week recovery period, and immunohistochemistry was used to assess macrophage response.Results: At 12 weeks, the Vicryl and Nylon groups had significantly larger ankle angles at to lift off, which is a measure of motor function, compared to injured controls (p < 0.05). Grafted rats displayed no difference in thermal response but hypersensitivity to mechanical stimuli compared to the uninjured hindlimb. The Nylon, Vicryl, and Fibrin Glue groups all had significantly less atrophy of the gastrocnemius muscle compared to injured controls (p < 0.0001). In the Fibrin Glue group, 3/9 grafts did not incorporate. The Nylon group had significantly less (p = 0.0004) axon growth surrounding the suture holes compared to the Vicryl group. There were no differences in the axon counts, motor neurons, or sensory neurons between all grafted rats.Conclusions: These results demonstrate that vicryl sutures work just as well as nylon for nerve recovery after injury and grafting.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"972-981"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examination time-distance characteristics of gait and pelvic kinematics in individuals with Diabetic polyneuropathy: a case-control study. 糖尿病多发性神经病患者步态和骨盆运动学的时间-距离特征：一项病例对照研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-25 DOI: 10.1080/01616412.2024.2367938

Büşra Kalkan Balak, Bahar Anaforoglu

{"title":"Examination time-distance characteristics of gait and pelvic kinematics in individuals with Diabetic polyneuropathy: a case-control study.","authors":"Büşra Kalkan Balak, Bahar Anaforoglu","doi":"10.1080/01616412.2024.2367938","DOIUrl":"10.1080/01616412.2024.2367938","url":null,"abstract":"Background: Diabetic Peripheral Neuropathy (DPN) disrupts body and movement biomechanics, increases mechanical stress during walking, and predisposes individuals to injuries owing to the repetitive effects of these stresses.Aims: This study aimed to assess and compare the impact of neuropathy on gait and pelvic kinematics in individuals with DPN.Methods: This case-control study included two groups: 23 individuals diagnosed with DPN aged between 35-70 and 23 healthy individuals aged-35-70. The BTS-G, a wireless motion sensor, was used to assess the time-distance characteristics of walking in all participants. The system analyzed data pertaining to walking speed, cadence, percentages of stance and swing phases, durations of walking cycles, double-step lengths, pelvic tilt, obliquity, and rotation symmetries.Results: There were no statistically significant differences between the groups in cadence, left and right stance phase percentages, or left and right swing phase percentages (p > 0.05). However, significant differences were observed between the groups in terms of speed, left and right walking cycle durations, and left and right double-step lengths (p < 0.05). Additionally, no statistically significant difference was found between the groups in pelvic tilt symmetry and left and right pelvic tilt range of motion values (p > 0.05). Nevertheless, significant differences were identified between the groups in pelvic obliquity symmetry, pelvic rotation symmetry, left and right pelvic obliquity range of motion, and left and right pelvic rotation range of motion values (p < 0.05).Conclusions: The findings of this study suggest that individuals with DPN exhibit decreased walking speed, prolonged gait cycle duration, increased double step length, and reduced pelvic obliquity and rotation range of motion.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"933-938"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of ICHD-3rd diagnostic criteria in determining the prevalence of migraine in childhood; school-based cross-sectional questionnaire study 利用 ICHD-3rd 诊断标准确定儿童偏头痛患病率；基于学校的横断面问卷调查研究

IF 1.9 4区医学

Neurological Research Pub Date : 2024-09-18 DOI: 10.1080/01616412.2024.2403860

Turgay Cokyaman, Ulgen Ozcan Erdem

引用次数: 0

Appraising motivation as a predictor of independence in individual activities of daily living in patients with subacute stroke: a retrospective study 评价动机是亚急性脑卒中患者个人日常生活活动独立性的预测因素：一项回顾性研究

IF 1.9 4区医学

Neurological Research Pub Date : 2024-09-16 DOI: 10.1080/01616412.2024.2403859

Takaaki Fujita, Ryuichi Kasahara, Megumi Kurita, Ryohei Jinbo, Yuichi Yamamoto, Yoko Ohira, Koji Otsuki, Kazuaki Iokawa

引用次数: 0

Reperfusion therapy and risk of post-stroke delirium 再灌注疗法与中风后谵妄的风险

IF 1.9 4区医学

Neurological Research Pub Date : 2024-09-16 DOI: 10.1080/01616412.2024.2403484

Mateusz Czyzycki, Joanna Pera, Tomasz Dziedzic

引用次数: 0

The effect of transcranial direct current stimulation on balance, gait function and quality of life in patients with stroke. 经颅直流电刺激对中风患者平衡、步态功能和生活质量的影响。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-09-01 Epub Date: 2024-06-02 DOI: 10.1080/01616412.2024.2362583

Nehir Toktas, Neslihan Duruturk, Şükran Güzel, Özlem Yürük, Selin Özen

{"title":"The effect of transcranial direct current stimulation on balance, gait function and quality of life in patients with stroke.","authors":"Nehir Toktas, Neslihan Duruturk, Şükran Güzel, Özlem Yürük, Selin Özen","doi":"10.1080/01616412.2024.2362583","DOIUrl":"10.1080/01616412.2024.2362583","url":null,"abstract":"Transcranial direct current stimulation (tDCS) has been used in various neurological diseases due to its positive effects on cortical excitability. The aim of our study is to examine the effects of tDCS in stroke and 28 patients with stroke were randomly divided into two groups as intervention and control groups. Balance was evaluated with the Timed Up and Go Test and Berg Balance Scale. Walking functions were evaluated using the 10-meter Walk Test and the 6 Minutes Walk Test, lower extremity function was evaluated by Fugl Meyer Lower Extremity Scale, quality of life by Stroke-Specific Quality of Life Scale (SS-QOL). A task-oriented physiotherapy and rehabilitation program was applied to both groups. In addition to the task-oriented program, anodal tDCS was applied in the intervention group and carried out with a current of 2 mA, 5 days a week, 20 min, for a total of 4 weeks. In the control group, after the flow was opened for 30 s and the patient felt a tingling sensation, it was turned off without the patient noticing. As a result, significant improvement was obtained in all parameters in both groups (p < 0.05). At the difference values of both groups, only SS-QOL mobility subgroup was significant and other parameters were not significant. Considering all these results, it can be seen that tDAS applied in addition to the task-oriented training program in individuals with stroke makes a positive contribution to the patients' balance, walking function and quality of life. We think that tDAS may be a feasible and safe additional approach in this patient group.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"868-875"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep disturbance in children with attention-deficit hyperactivity disorder: relationship with melatonin and behavior. 注意力缺陷多动障碍儿童的睡眠障碍：与褪黑激素和行为的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI: 10.1080/01616412.2024.2359261

Ana Luiza Decanini Miranda de Souza, Célia Maria Giacheti, Maria Clara Helena Do Couto, Caio Sérgio Galina Spilla, Nathani Cristina da Silva, Mahara Proença, Luciana Pinato

{"title":"Sleep disturbance in children with attention-deficit hyperactivity disorder: relationship with melatonin and behavior.","authors":"Ana Luiza Decanini Miranda de Souza, Célia Maria Giacheti, Maria Clara Helena Do Couto, Caio Sérgio Galina Spilla, Nathani Cristina da Silva, Mahara Proença, Luciana Pinato","doi":"10.1080/01616412.2024.2359261","DOIUrl":"10.1080/01616412.2024.2359261","url":null,"abstract":"Aim: To evaluate the prevalence and types of sleep problems and their correlations with melatonin content and behavior in Attention-Deficit Hyperactivity Disorder (ADHD) children.Method: Sleep in ADHD children and typically developing children (TD) aged 6-14 was assessed by the Sleep Disorders Scale for Children (SDSC) and actigraphy, salivary melatonin quantified by ELISA, and behavior was analyzed using the Strengths and Difficulties Questionnaire.Results: ADHD children showed a higher frequency of sleep disturbances, higher sleep latency, and lower sleep efficiency than in the TD group. The ADHD group presented lower melatonin nocturnal content compared to the TD group. Disorders of Initiating and Maintaining Sleep (DIMS) was moderately associated with nocturnal melatonin. The total behavior difficulties were correlated with Disorders of Initiating and Maintaining Sleep (DIMS), Sleep/Wake Transition Disorders (SWTD), Disorders of Excessive Somnolence (DES), Sleep Hyperhidrosis (SHY) and Total SDSC Score. The behavior was the only determinant of the total SDSC score (R2 = 0.499; p < 0.002).Conclusion: This study provides, for the first time, evidence that among the frequent sleep disturbances in ADHD, the disorders in initiating and maintaining sleep are associated with the low levels of melatonin found in this population. Additionally, these, along with other sleep disturbances, are linked to behavioral problems in ADHD.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"803-811"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of botulinum toxin type a combined with physical therapy on functional capacity in children with spastic cerebral palsy: a randomized controlled clinical trial. A 型肉毒毒素联合物理疗法对痉挛性脑瘫患儿功能能力的影响：随机对照临床试验。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-09-01 Epub Date: 2024-05-26 DOI: 10.1080/01616412.2024.2359260

Maria Eliege de Souza, Caroline Razera Ferreira, Claudia Santos Oliveira, Maria Fernanda Molledo Secco, Paulo Fonseca Junior, Paulo Roberto Garcia Lucareli, Daniela Aparecida Biasotto-Gonzalez, Fabiano Politti

{"title":"Effect of botulinum toxin type a combined with physical therapy on functional capacity in children with spastic cerebral palsy: a randomized controlled clinical trial.","authors":"Maria Eliege de Souza, Caroline Razera Ferreira, Claudia Santos Oliveira, Maria Fernanda Molledo Secco, Paulo Fonseca Junior, Paulo Roberto Garcia Lucareli, Daniela Aparecida Biasotto-Gonzalez, Fabiano Politti","doi":"10.1080/01616412.2024.2359260","DOIUrl":"10.1080/01616412.2024.2359260","url":null,"abstract":"Objective: Investigate the effects of botulinum toxin type A (BoNT-A) combined with physical therapy on functional capacity in children with spastic cerebral palsy (CP).Methods: Twenty-four children with spastic CP were treated with either BoNT-A and physical therapy or physical therapy alone.Results: Significant differences (p < 0.05) were found after 30 days of treatment for the Berg Scale, Timed Up and Go (TUG) test, Ashworth Scale and Pediatric Evaluation of Disability Inventory (PEDI) and after three months for the Berg Scale, TUG test and PEDI. No significant differences (p > 0.05) were found in the control group.Discussion: BoNT-A combined with physical therapy leads to significant improvements in spasticity and functionality in children with CP within a period of three months from the onset of treatment.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"796-802"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0