Effects of topically applied sodium-2-mercaptoethanesulfonate (MESNA) in the prevention of epidural fibrosis following lumbar laminectomy in rats.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI:10.1080/01616412.2025.2498688

Erdal Resit Yilmaz, Ekrem Yalcin, Ata Turker Arikok, Muhammed Erkan Emrahoglu, Habibullah Olgun, Eylem Eren Eyupoglu, Askin Esen Hasturk

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引用次数: 0

Abstract

Objective: In spinal surgery practices through which nervous tissues are released as a result of decompression, the occurrence of fibrosis is a substantial issue that reduces the success rates. This study investigated the positive impacts of topical application of sodium-2-mercaptoethanesulfonate (MESNA) on the prevention of fibrosis at the surgical site.

Material and methods: All groups were anesthetized 4 weeks after the procedure, and they were subjected to neuromonitoring. Subsequently, after the rats were killed, the development of fibrosis was evaluated in a macroscopic manner by creating a surgical site through the previous incision. The left L4 root was excised along with its peripheral tissue, and the prevalence of the fibrosis was evaluated microscopically.

Results: The fibrous tissue was observed to be less prevalent in the group where MESNA was applied, as per the macroscopic and histopathologic scoring.

Conclusion: The positive macroscopic and microscopic effectiveness of the topically applied MESNA solution to prevent fibrosis was demonstrated. Further research is needed to substantiate this potential of MESNA.

查看原文本刊更多论文

局部应用2-巯基乙磺酸钠（MESNA）预防大鼠腰椎椎板切除术后硬膜外纤维化的作用。

目的：在减压释放神经组织的脊柱外科实践中，纤维化的发生是降低成功率的一个重要问题。本研究探讨了局部应用2-巯基乙磺酸钠（MESNA）对预防手术部位纤维化的积极影响。材料与方法：各组术后4周麻醉，行神经监测。随后，在杀死大鼠后，通过先前的切口创建手术部位，以宏观方式评估纤维化的发展。切除左L4根及其周围组织，显微镜下评估纤维化的发生率。结果：根据宏观和组织病理学评分，观察到纤维组织在应用MESNA的组中较少流行。结论：局部应用MESNA溶液预防纤维化具有良好的宏观和微观效果。需要进一步的研究来证实MESNA的这种潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.