雷公藤红素治疗可减轻阿尔茨海默病模型小鼠的炎症反应。

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-08-05 DOI:10.1080/01616412.2025.2534077

Fanfan Cao, Pan Zhang, Zelun Zheng, Ping Wang, Ying Wang, Qin Shi, Denghai Zhang, Limin Xu

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引用次数: 0

摘要

目的：阿尔茨海默病（AD）是最常见的神经退行性疾病。不幸的是，目前有效的治疗阿尔茨海默病的方法有限，因此，迫切需要发现新的抗阿尔茨海默病药物。Celastrol是一种植物衍生的三萜，具有抗氧化和抗炎活性。方法和结果：在体内和体外实验中，我们发现celastrol处理可以促进小胶质细胞M2极化，抑制炎症因子的表达。Celastrol通过调节TLR4/NFκB通路显著改善AD小鼠认知功能，过表达TLR4逆转CEL对AD模型小鼠认知功能的保护作用。提示TLR4/NFκB在调节炎症反应中起关键作用。结论：综上所述，celastrol可通过TLR4/NFκB通路促进小胶质细胞M2极化，从而减轻AD小鼠的炎症反应。

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Celastrol treatment attenuates the inflammatory response in Alzheimer's disease model mice.

Objective: Alzheimer's disease (AD) is the most common neurodegenerative disease. Unfortunately, current effective therapeutics for AD are limited, and thus, the discovery of novel anti-AD agents is urgently needed. Celastrol, a plant-derived triterpene, has both antioxidant and anti-inflammatory activities.

Methods and results: Here, we found that celastrol treatment promoted microglial M2 polarization and inhibited inflammatory factor expression in both in vivo and in vitro experiments. Celastrol treatment significantly improved cognitive function in AD mice by regulation the TLR4/NFκB pathway, overexpression TLR4 reversed the protective effect of CEL to cognitive function in AD model mice. Suggesting that TLR4/NFκB plays a crucial role in regulating the inflammatory response.

Conclusion: Taken together, the results indicate that celastrol treatment attenuated the inflammatory response in AD mice by promoting microglial M2 polarization via the TLR4/NFκB pathway.

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.