Neurological Research最新文献

{"title":"Unveiling the causal effects of phosphatidylethanolamine (18:1_0:0) via glutamine conjugate of C₆H₁₀O₂ (2) and X-23648 in Parkinson's disease: insights from mediation Mendelian randomization.","authors":"Can Hu, Juan Deng, Yunfeng Yu, Keke Tong, Siyang Bai, Guomin Zhang, Lusha Yao","doi":"10.1080/01616412.2025.2536076","DOIUrl":"10.1080/01616412.2025.2536076","url":null,"abstract":"<p><strong>Objective: </strong>The effects of lipidome and its metabolites on Parkinson's disease (PD) have not been fully elucidated. This study aimed to assess the causal effects of lipidome on PD and the mediated effects of metabolites using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Datasets of the lipidome, metabolites, and PD were acquired from genome-wide association studies, and single nucleotide polymorphisms were screened according to the basic assumptions of MR. Subsequently, inverse variance weighted was used as the main tool to assess the causal effects of lipidome on PD and the mediated effects of metabolites. Finally, the MR-Egger intercept, Cochran's Q test, and leave-one-out sensitivity analysis were used to assess the horizontal pleiotropy, heterogeneity, and robustness of the results, respectively.</p><p><strong>Results: </strong>The MR analysis showed that phosphatidylethanolamine (18:1_0:0) reduced genetic susceptibility to PD by lowering glutamine conjugate of C₆H₁₀O₂ (2) levels (mediated proportion: 15.80%; mediated effect: -0.024, 95% confidence interval [CI] -0.046 to -0.001, <i>p</i> = 0.040) and increasing X-23648 levels (mediated proportion: 15.20%; mediated effect: -0.022, 95% CI -0.045 to -0.001, <i>p</i> = 0.030). The MR-Egger intercept showed no horizontal pleiotropy (<i>p</i> ≥ 0.05) for these results. Cochran's Q and sensitivity analyses showed that the results were not heterogeneous and were robust.</p><p><strong>Conclusion: </strong>Our findings indicate that phosphatidylethanolamine (18:1_0:0) reduces the risk of PD by regulating glutamine conjugate of C₆H₁₀O₂ (2) and X-23648, providing genetic insights into the pathogenesis of PD. However, these results are based on European populations and require further experimental validation.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of wake-up stroke: a systematic review and meta-analysis.","authors":"Yuting Zhao, Jia Li, Ying Zhu, Qiuxia Qian, Xiaoling Qian, Longchun Hua, Jianxun Cao, Yuxia Ma","doi":"10.1080/01616412.2025.2534517","DOIUrl":"https://doi.org/10.1080/01616412.2025.2534517","url":null,"abstract":"<p><strong>Background: </strong>Wake-up stroke (WUS) is a subgroup of ischemic stroke in which patients show no abnormality before sleep, while wake up with neurological deficits, and the prevalence varied widely across studies. To obtain a true estimate of WUS, we conducted a systematic review and meta-analysis of previously published data.</p><p><strong>Methods: </strong>PubMed, the Cochrane Library, Web of Science, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure Database (CNKI), Wanfang Database and Weipu Database (VIP) were searched from their inception through 1 April 2025 to identify population-based, observational studies that reported the prevalence of WUS.</p><p><strong>Results: </strong>The meta-analysis included 37 studies involving 196,744 individuals. The pooled prevalence of WUS was 23.1% (95% CI: 21.1%-25.1%, I² = 98.8%). The results of the subgroup analysis showed that the pooled prevalence of WUS was 22.8% (95% CI: 21%-25%) in women and 24% (95% CI: 22%-26%) in men. The pooled prevalence of WUS based on the cross-sectional studies and cohort studies, respectively, was 25.1% (95% CI: 23%-27%) and 17.4% (95% CI: 15%-20%). Based on the regional analysis, the prevalence of WUS was 25% (95% CI: 23%-27%) in Asia, 18.5% (95% CI: 14%-22%) in Europe, and 24.1% (95% CI: 18%-31%) in North America.</p><p><strong>Conclusions: </strong>The prevalence of WUS is 23.1%, with higher rates observed in men and the Asian region. Increased awareness and training among healthcare professionals are essential for early recognition, potentially improving diagnosis and management in emergency settings. Promoting education on WUS is also vital for reducing associated morbidity and mortality.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal expression of miR-136-5p in glioma cancer patients and its correlation with CT signs.","authors":"Jiaxin Yin, Xiang Zhang","doi":"10.1080/01616412.2025.2532818","DOIUrl":"https://doi.org/10.1080/01616412.2025.2532818","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRNAs) have attracted considerable attention as promising new tumor biomarkers.</p><p><strong>Aims: </strong>This study primarily integrates computed tomography (CT) findings to investigate the expression and potential implications of miR-136-5p in glioma.</p><p><strong>Methods: </strong>Human glioma samples were obtained from 122 glioma tissues and 80 adjacent tissues resected by surgery from confirmed patients. Reverse transcription quantitative PCR (RT-qPCR) was used to detect the expression of the genes. Receiver Operating Characteristic (ROC) curve was used to evaluate the diagnostic value of miR-136-5p combined with Computed Tomography (CT) in glioma. Correlation analysis was conducted employing Pearson's method. The target genes of miR-136-5p were identified using the TargetScan online database and validated through dual luciferase reporter assays.</p><p><strong>Results: </strong>In glioma tissues, the expression of miR-136-5p was markedly downregulated. Its expression correlates with CT signs and clinicopathological features of glioma patients. Both CT detection and miR-136-5p expression showed significant potential in diagnosing glioma, and combining the two improved the diagnostic value of glioma. Furthermore, the overexpression of miR-136-5p has been shown to negatively regulate the expression of the BCL9L gene in U87 and U251 glioma cell lines, thereby inhibiting tumor cell proliferation and promoting apoptotic processes.</p><p><strong>Conclusions: </strong>miR-136-5p is downregulated in glioma tissues and closely correlates with tumor CT signs. It may serve as a promising biomarker to assist in glioma diagnosis using CT scans.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous sinus stenting for idiopathic intracranial hypertension in the MENA region: initial results from the VEHICLE Registry.","authors":"Ossama Yassin Mansour, Aser Goma, Jaidaa Mekky, Mohamed Shafik, Farid Aladham, Ibrahim Alnaami, Hosam Maher Al-Jehani, Abdulrahman Alshamy, Faisal Alghamdi, Ozlem Aykac, Mohamed Khaled Elwia, Hany El Hamadani, Mehdi Farhodi, Mahmoud Galal, Mohamed Ghorbani, Erdem Gurkas, Nadia Hammami, Mohamed Hamdy, Tamer Hassan, Farouk Hassan, Syed I Hussain, Yahia Imam, Seby John, Wael Khalifa, Amina El Khamlichi, Amr Mahmoud, Mostafa Mahmoud, Ehab S Mohamed, Nada Nasr, Atilla Ozcan Ozdemir, Umair Rashid, Salma Said, Abdulmonem Saied, Mohammed Wasay, Hany Zaki Eldeen","doi":"10.1080/01616412.2025.2533420","DOIUrl":"https://doi.org/10.1080/01616412.2025.2533420","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical outcomes and safety of venous sinus stenting in idiopathic intracranial hypertension (IIH) patients across multiple centers in the Middle East and North Africa (MENA) region through the Venous stEnt for idiopathic intraCranial hypertEnsion (VEHICLE) Registry.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of prospectively collected data from the VEHICLE Registry (NCT06692790) between August 2023 and August 2024. From an initial pool of 187 cases, 100 patients met all inclusion criteria: IIH diagnosis based on modified Dandy criteria, neuroimaging-confirmed venous sinus stenosis, refractory or intolerant to medical therapy, underwent venous pressure manometry, and had complete follow-up data. All patients underwent venous sinus stenting at nine collaborating centers.</p><p><strong>Results: </strong>Of 100 patients, 73% were female. All presented with headaches, while 87% reported visual disturbances. Venous stenoses predominantly affected the right transverse sinus (56%). At six months, 83% achieved marked symptom resolution, 80% had normalized optic nerve heads, and stent patency was confirmed in 90%. Papilledema grades improved significantly from median Grade III at baseline to Grade I at 6 months (<i>p</i> < 0.001), correlating with increased QOL scores (<i>p</i> < 0.001). Sixteen percent required revision procedures. Complication rates were low, with no procedure-related mortality.</p><p><strong>Discussion: </strong>Significant improvements in headache, papilledema, and quality of life were observed with a favorable safety profile with venous sinus stenting for medically refractory IIH. However, the retrospective design and lack of a control group limit definitive conclusions about efficacy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue and its contributing factors in people with multiple sclerosis: a cross-sectional study.","authors":"Ida Mohammadi, Saeed Vaheb, Shahryar Rajai Firouzabadi, Mohammad Yazdan Panah, Vahid Shaygannejad, Omid Mirmosayyeb","doi":"10.1080/01616412.2025.2537328","DOIUrl":"https://doi.org/10.1080/01616412.2025.2537328","url":null,"abstract":"<p><strong>Background: </strong>Fatigue is a common and debilitating symptom in people with multiple sclerosis (PwMS), yet its contributing factors are not fully understood. This study examined how fatigue severity relates to physical activity, limb function, mood, and demographics within a unified framework.</p><p><strong>Methods: </strong>In this cross-sectional study, PwMS were recruited in Isfahan, Iran, from April 2023 to April 2024. Participants completed the Fatigue Severity Scale, and data were collected on demographics, cognitive processing speed (Symbol Digit Modalities Test), physical activity (IPAQ), upper limb function (9-Hole Peg Test), lower limb function (Timed 25-Foot Walk), depression, and anxiety (Beck inventories). Associations between fatigue severity and these factors were analyzed using stepwise linear and logistic regression models.</p><p><strong>Results: </strong>Among 141 participants (90.1% female; mean age: 37.87 ± 9.74 years), fatigue prevalence was 61.7%. Higher fatigue severity was significantly associated with greater depression (B (95% CI) = 0.47 (0.32, 0.63), β = 0.481), poorer lower limb function (B (95% CI) = 1.82 (0.48, 3.16), β = 0.234), progressive MS (B (95% CI) = 7.38 (1.85, 12.91), β = 0.186), and lower physical activity (B (95% CI) = -0.0006 (-0.001, -0.0001), β = -0.156). Logistic regression indicated that being married (OR (95% CI) = 3.06 (1.20, 7.80), worse lower limb function (OR (95% CI) = 1.55 (1.01, 2.37), and higher depression scores (OR (95% CI) = 1.06 (1.01, 1.10) were associated with increased odds of clinically significant fatigue.</p><p><strong>Conclusion: </strong>Fatigue was common among PwMS and was independently associated with depression, reduced lower extremity function, progressive MS, lower physical activity, and marital status. These findings highlight key physical and psychological factors associated with fatigue; however, longitudinal studies are needed to establish causality.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dl-3-n-Butylphthalide alleviates cerebral ischemia-reperfusion injury via the miR-20a-5p/XIAP axis.","authors":"Guang Yao, Juan Xu, Qiong Chen, Ruping Xiang","doi":"10.1080/01616412.2025.2539488","DOIUrl":"https://doi.org/10.1080/01616412.2025.2539488","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the neuroprotective effects of Dl-3-n-Butylphthalide (NBP) against cerebral ischemia-reperfusion injury (CIRI), with a focus on NBP's underlying molecular mechanism.</p><p><strong>Methods: </strong>A CIRI rat model was established, followed by treatment with NBP with/without microRNA-20a-5p (miR-20a-5p) mimic or negative control. Neurological deficits, brain infarct size, and histopathological changes were assessed. In vitro, an oxygen-glucose deprivation/reoxygenation (OGD/R)-induced PC12 cell model was developed, followed by cell viability and apoptosis evaluation. miR-20a-5p, X-linked inhibitor of apoptosis protein (XIAP), and apoptosis-related protein levels were detected. A dual-luciferase reporter assay was performed to confirm the interaction between miR-20a-5p and XIAP.</p><p><strong>Results: </strong>NBP treatment significantly restored neurological function, reduced infarct size, and inhibited neuronal apoptosis. Mechanistically, NBP downregulated miR-20a-5p and upregulated XIAP. The protective effects of NBP were abolished by miR-20a-5p overexpression.</p><p><strong>Conclusion: </strong>NBP exerts neuroprotective effects against CIRI by modulating the miR-20a-5p/XIAP axis. NBP may serve as a therapeutic agent for CIRI.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ApoE ε4 allele, homocysteine, and inflammatory factors (hs-CRP, IL-6, TNF-α) with cognitive dysfunction in Alzheimer's disease patients and development and validation of a predictive model.","authors":"Li Wang, Qing Sun","doi":"10.1080/01616412.2025.2539489","DOIUrl":"10.1080/01616412.2025.2539489","url":null,"abstract":"<p><strong>Objective: </strong>This study focuses on the cognitive dysfunction in patients with Alzheimer's disease (AD), aims to in-depth analysis of the Apolipoprotein E (ApoE) gene polymorphism, homocysteine (Hcy) and the intrinsic relationship between the disease, and build accurate and effective prediction model.</p><p><strong>Methods: </strong>A total of 193 AD patients were divided into a training set (<i>n</i> = 135) and a validation set (<i>n</i> = 58) according to the ratio of 7:3. The risk factors were screened by univariate and multivariate Logistic regression in the training set, and the nomogram model was constructed. The receiver operating characteristic curve (ROC) was drawn and the calibration curve was used to evaluate the effectiveness of the model. The model was verified in the validation set, and the clinical value was evaluated by decision curve analysis (DCA).</p><p><strong>Results: </strong>The multivariate Logistic regression analysis showed that high PSQI score, elevated Hcy, ApoE ε4 allele carrying, decreased folic acid, elevated hs-CRP and IL-6 were the independent risk factors for cognitive dysfunction in AD patients (<i>p</i> < 0.05). The nomogram model performed well in the training and validation sets for calibration and prediction, with C-index values of 0.863 and 0.769, respectively, area under ROC curve (AUC) values of 0.870 and 0.771.</p><p><strong>Conclusion: </strong>The nomogram prediction model constructed based on ApoE gene polymorphism and Hcy et al. can be used to predict the risk of cognitive dysfunction in AD patients and provide a reference basis for formulating personalized intervention plan in clinic. However, it still needs further verification by large sample and multi-center study.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPEDITION: an Exploratory deep learning method to quantitatively predict hematoma progression after intracerebral hemorrhage.","authors":"Siqi Chen, Zixiao Li, Yinsheng Li, Donghua Mi","doi":"10.1080/01616412.2025.2536668","DOIUrl":"https://doi.org/10.1080/01616412.2025.2536668","url":null,"abstract":"<p><strong>Objects: </strong>This study aims to develop an Exploratory deep learning method to quantitatively predict hematoma progression (EXPEDITION in short) after intracerebral hemorrhage (ICH).</p><p><strong>Methods: </strong>Patients with primary ICH in the basal ganglia or thalamus were retrospectively enrolled, and their baseline non-contrast CT (NCCT) image, CT perfusion (CTP) images, and subsequent re-examining NCCT images from the 2nd to the 8th day after baseline CTP were collected. The subjects who had received three or more re-examining scans were categorized into the test data set, and others were assigned to the training data set. Hematoma volume was estimated by manually outlining the lesion shown on each NCCT scan. Cerebral venous hemodynamic feature was extracted from CTP images. Then, EXPEDITION was trained. The Bland-Altman analysis was used to assess the prediction performance.</p><p><strong>Results: </strong>A total of 126 patients were enrolled initially, and 73 patients were included in the final analysis. They were then categorized into the training data set (58 patients with 93 scans) and the test data set (15 patients with 50 scans). For the test set, the mean difference [mean ±1.96SD] of hematoma volume between the EXPEDITION prediction and the reference is -0.96 [-9.64, +7.71] mL. Specifically, in the test set, the consistency between the true and the predicted volume values was compared, indicating that the EXPEDITION achieved the needed accuracy for quantitative prediction of hematoma progression.</p><p><strong>Conclusions: </strong>An Exploratory deep learning method, EXPEDITION, was proposed to quantitatively predict hematoma progression after primary ICH in basal ganglia or thalamus.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: regarding the article \"efficacy and safety of hematopoietic and mesenchymal stem cells in multiple sclerosis: a meta-analysis\".","authors":"Murat Kürtüncü","doi":"10.1080/01616412.2025.2534518","DOIUrl":"https://doi.org/10.1080/01616412.2025.2534518","url":null,"abstract":"","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the relationship between autoimmune neurologic diseases and mental disorders: evidence from Mendelian randomization study.","authors":"Yu Shen, WenWen Xiang, Qun Xiong, Si Luo, Hao Chen, Ziwei Song, Yusen Qiu, Lijun Pang, Daojun Hong","doi":"10.1080/01616412.2025.2534082","DOIUrl":"https://doi.org/10.1080/01616412.2025.2534082","url":null,"abstract":"<p><strong>Introduction: </strong>Traditional epidemiologic studies suggest that autoimmune neurologic diseases may be associated with mental disorders (MDs). We used Mendelian randomization (MR) studies to explore the causal relationship between autoimmune neurologic diseases and MDs from the genetic perspective.</p><p><strong>Methods: </strong>In our study, autoimmune neurologic diseases include multiple sclerosis (MS), neuromyelitis optica (NMO), and myasthenia gravis (MG); MDs include anxiety, major depressive disorder (MDD), attention deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar affective disorder (BIP). A two-sample MR approach was used to explore causal relationships. The inverse variance weighted (IVW) method was the primary method for MR analysis. In addition, we included all MG datasets for meta-analysis after MR analysis with ADHD.</p><p><strong>Results: </strong>Regarding the causal effects of MDs on autoimmune neurologic diseases, our analyses revealed a causal relationship between genetically predicted ADHD and MG (OR 2.250; 95% CI 1.267-3.998; <i>p</i> = 0.006), and no potential genetic causal relationships were found between the other diseases. However, according to the MR‒Egger analysis, there was no indication of directional pleiotropy. For the causal effects of autoimmune neurologic diseases on MDs, no potential genetic causal relationships were identified between any of the diseases. We performed a meta-analysis for MG and ADHD, there was no significant genetic causal relationship between ADHD and MG (OR 1.30 (95% CI 0.95-1.79); <i>p</i> = 0.10).</p><p><strong>Conclusion: </strong>This study revealed that there was no genetic mechanism linking autoimmune neurologic diseases and MDs to each other. These findings provide a foundation for the prevention and treatment of comorbid conditions in clinical research.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}