Neurological Research最新文献_第8页

Prevalence and clinical correlates of nonmotor symptoms in Parkinson's disease in a tertiary health-care center in Turkey. 土耳其一家三级医疗保健中心帕金森病患者非运动症状的患病率和临床相关性。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1080/01616412.2024.2381162

H Onder, S Comoglu

{"title":"Prevalence and clinical correlates of nonmotor symptoms in Parkinson's disease in a tertiary health-care center in Turkey.","authors":"H Onder, S Comoglu","doi":"10.1080/01616412.2024.2381162","DOIUrl":"10.1080/01616412.2024.2381162","url":null,"abstract":"Objective: The objective was to determine the prevalence and clinical correlates of nonmotor symptoms in Parkinson's disease patients in movement disorders outpatient clinics.Methods: We enrolled all consecutive PD patients who visited our movement disorders outpatient clinics between January and December 2023; and agreed to participate in the study. In addition to the evaluation of demographic and clinical features, clinical scales, including the MDS-UPDRS, NMSS, and FOOGQ, were performed.Results: Overall, we enrolled 163 PD subjects with a mean age of 63.9 ± 10.4 (F/M = 27/136). The disease duration was 3.5 (20) y [median (range)]. The median score of the NMSS was 41 points. The NMSs burden levels were severe in 25.2%, and very severe in 25.2% of the subjects. The subitems with the highest scores were sleep/fatigue, mood/cognition, urinary, and miscellaneous. The analyses within the patient group with newly diagnosed PD also revealed high NMSS scores. Comparisons of the NMSS between distinct PD stages revealed greater NMSS scores in the severe stage than in the mild stage (p = 0.001). Correlation analyses between the clinical scores and the NMSS scores revealed positive correlations between the NMSS scores and the scores on all the clinical scales including the MDS-UPDRS 1-4, and FOGQ.Conclusion: We reported the first data regarding the NMS burden in PD patients from Turkey. We found a high prevalence and severity of various domains of NMSs, most of which were sleep/fatigue, mood/cognition, urinary, and miscellaneous. More than half of the patients had severe to very severe NMS burden. Although NMSs were more common severe-stage disease, they were also prevalent in the subgroup with newly diagnosed patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1054-1062"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors of cerebral aneurysms rupture in an Indonesian population. 印度尼西亚人口中脑动脉瘤破裂的风险因素。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-06 DOI: 10.1080/01616412.2024.2376308

Beny Rilianto, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Pratiwi Raissa Windiani, Kelvin Theandro Gotama, Muhammad Kusdiansah, Abrar Arham

{"title":"Risk factors of cerebral aneurysms rupture in an Indonesian population.","authors":"Beny Rilianto, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Pratiwi Raissa Windiani, Kelvin Theandro Gotama, Muhammad Kusdiansah, Abrar Arham","doi":"10.1080/01616412.2024.2376308","DOIUrl":"10.1080/01616412.2024.2376308","url":null,"abstract":"Background: The demographic, clinical, and angiographic features of ruptured aneurysms compared to unruptured cerebral aneurysms in Indonesia are still limited. This study aims to determine risk factors for rupture according to clinical patterns and morphological features in the Indonesian population.Method: We retrospectively reviewed all cerebral aneurysm registries at the largest comprehensive stroke center in Indonesia from January 2019 to January 2022. We compared demographic and vascular risk factors as well as angiographic features between patients with ruptured and unruptured aneurysms with univariate and multivariate analyses.Results: Of 275 patients, 231 (84%) had ruptured cerebral aneurysms. We found a significant difference between the ruptured and unruptured groups in variables such as age, hypertension, dyslipidemia, smoking, location, and type of aneurysm. It was found that only the anterior circulation site (OR 4.91, 95% CI 1.47-16.48; p < 0.01) and saccular type (OR 5.45, 95% CI 1.42-20.93; p = 0.01) were significantly linked to ruptured aneurysms.Conclusion: Our findings revealed that anterior location and saccular type were substantially linked with ruptured aneurysms in the Indonesian population.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"989-995"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

USP7 alleviates neuronal inflammation and apoptosis in spinal cord injury via deubiquitinating NRF1/KLF7 axis. USP7 通过去泛素化 NRF1/KLF7 轴减轻脊髓损伤中的神经元炎症和凋亡。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-15 DOI: 10.1080/01616412.2024.2376999

Qifei Xu, Fanguo Kong, Guanghui Zhao, Junwei Jin, Shengkai Feng, Ming Li

{"title":"USP7 alleviates neuronal inflammation and apoptosis in spinal cord injury via deubiquitinating NRF1/KLF7 axis.","authors":"Qifei Xu, Fanguo Kong, Guanghui Zhao, Junwei Jin, Shengkai Feng, Ming Li","doi":"10.1080/01616412.2024.2376999","DOIUrl":"10.1080/01616412.2024.2376999","url":null,"abstract":"Background: Ubiquitin-specific protease 7 (USP7) has been found to be associated with motor function recovery after spinal cord injury (SCI). Therefore, its role and mechanism in SCI process need further exploration.Methods: SCI rat models were established via performing laminectomy at the T9-T11 spinal vertebrae and cutting spinal cord tissues. SCI cell models were constructed by inducing PC12 cells with lipopolysaccharide (LPS). The protein levels of USP7, nuclear respiratory factor 1 (NRF1), Krüppel-like factor 7 (KLF7) and apoptosis-related markers were detected by western blot. Cell viability and apoptosis were tested by cell counting kit-8 assay and flow cytometry. The contents of inflammatory factors were examined using ELISA. The interaction between NRF1 and USP7 or KLF7 was analyzed by co-immunoprecipitation assay, chromatin immunoprecipitation assay and dual-luciferase reporter assay, respectively.Results: USP7 was downregulated in SCI rat models and LPS-induced PC12 cells. Overexpressed USP7 promoted viability, while repressed apoptosis and inflammation in LPS-induced PC12 cells. USP7 could stabilize NRF1 protein expression via deubiquitination, and NRF1 knockdown reversed the protective effect of USP7 against LPS-induced PC12 cell injury. NRF1 is bound to KLF7 promoter to enhance its transcription. NRF1 overexpression inhibited LPS-induced PC12 cell inflammation and apoptosis via increasing KLF7 expression.Conclusion: USP7 alleviated inflammation and apoptosis in LPS-induced PC12 cells via NRF1/KLF7 axis, indicating that targeting of USP7/NRF1/KLF7 axis might be a promising treatment strategy for SCI.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1008-1017"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No causal link between herpes zoster and ischemic stroke: evidence from Mendelian randomization study. 带状疱疹与缺血性中风之间没有因果关系：孟德尔随机研究的证据。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-14 DOI: 10.1080/01616412.2024.2363098

Yao Wang, Peng Xu, Ke Wang, Xinchen Ji, Jing Lu, Tianying Chang, Baitong Wang, Dongmei Zhang, Xinzhi Chen, Jian Wang

{"title":"No causal link between herpes zoster and ischemic stroke: evidence from Mendelian randomization study.","authors":"Yao Wang, Peng Xu, Ke Wang, Xinchen Ji, Jing Lu, Tianying Chang, Baitong Wang, Dongmei Zhang, Xinzhi Chen, Jian Wang","doi":"10.1080/01616412.2024.2363098","DOIUrl":"10.1080/01616412.2024.2363098","url":null,"abstract":"Objective: The association between herpes zoster (HZ) and stroke has been the subject of much previous research. Nevertheless, the connection remains ambiguous. A two-sample Mendelian randomisation study was conducted to explore the potential causal link between HZ and ischaemic stroke, including its subtypes.Methods: For our MR analysis, we identified genetic instrumental variables related to both HZ and stroke by screening two prominent publicly accessible genome-wide association study databases. The primary approach involved using the inverse variance weighting method. To supplement this, we also employed methods such as MR-Egger regression, the weighted median approach, simple and weighted models. Lastly, to ascertain the stability and reliability of the results, we conducted tests for heterogeneity detection, horizontal pleiotropy assessment, and a leave-one-out analysis.Results: The genetically predicted HZ did not indicate an association with stroke risk ([OR] 1.041; 95% [CI] 0.958-1.131;p = 0.336). This lack of association also held true for different subtypes of stroke: ischaemic stroke (OR = 1.047, 95% CI = 0.955-1.148, p = 0.323), large vessel stroke (OR = 1.13, 95% CI = 0.90-1.41, p = 0.272), cardioembolic stroke (OR = 1.020, 95% CI = 0.859-1.211, p = 0.816), small vessel stroke (OR = 1.14, 95% CI = 0.93-1.40, p = 0.195), and lacunar stroke (OR = 1.195, 95% CI = 0.967-1.476, p = 0.097).Conclusion: This MR study showed that not uncover a causal link between herpes zoster and ischaemic stroke. Additional research will be necessary in the future to shed light on the fundamental mechanisms involved.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"907-916"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of antisaccades in patients with cerebral small vessel disease accompanied by white matter hyperintensities. 伴有白质高密度症的脑小血管疾病患者的反斜视表现。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-18 DOI: 10.1080/01616412.2024.2367934

Huimin Fan, Jing Feng, Yuchuan Ding, Pan Gu, Liying Wang, Xiaomeng Chen, Xiaokun Geng

{"title":"Performance of antisaccades in patients with cerebral small vessel disease accompanied by white matter hyperintensities.","authors":"Huimin Fan, Jing Feng, Yuchuan Ding, Pan Gu, Liying Wang, Xiaomeng Chen, Xiaokun Geng","doi":"10.1080/01616412.2024.2367934","DOIUrl":"10.1080/01616412.2024.2367934","url":null,"abstract":"Objectives: The antisaccades (AS) task is considered a reliable indicator of inhibitory control of eye movements in humans. Achieving good AS performance requires efficient cognitive processes that are sensitive to changes in brain structure. White matter hyperintensities (WMH) can cause subcortical-cortical dysconnectivity, affecting diverse cognitive domains. Thus, the AS task was investigated in patients with WMH in cerebral small vessel disease (CSVD).Methods: In this retrospective study, 75 participants with WMH, determined by neuroimaging standards for CSVD research, were admitted to the Department of Neurology of Beijing Luhe Hospital, Capital Medical University from January 2021 to December 2022. All subjects underwent the AS task, Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and 3.0T brain MRI. Additionally, 61 healthy subjects were recruited to characterize WMH profiles.Results: Compared to the control group, patients with WMH had a significantly increased AS error rate (49.81%, p = 0.001) and lower gain (76.00%, p = 0.042). The AS error rate was significantly higher in patients with WMH in the frontal lobe than in those without WMH (p = 0.004). After adjusting for confounders (age), a positive correlation was found between the AS error rate and MoCA scores for patients with WMH (coefficient = 0.262, p = 0.024).Conclusions: Patients with WMH due to CSVD exhibited abnormal AS performances, particularly in the frontal lobe. The eye movement paradigms, the new diagnostic forms in neurology, can be utilized to investigate the distributed cortical and subcortical systems involved in cognitive control processes, offering simple, well-tolerated and highly sensitive advantages over traditional measures.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"917-924"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and diagnostic delay in cluster headache in Egypt. 埃及丛集性头痛的临床特征和诊断延误。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-27 DOI: 10.1080/01616412.2024.2367936

Mona Af Nada, Salsabil Abo Al-Azayem, Mona K Moawad

{"title":"Clinical characteristics and diagnostic delay in cluster headache in Egypt.","authors":"Mona Af Nada, Salsabil Abo Al-Azayem, Mona K Moawad","doi":"10.1080/01616412.2024.2367936","DOIUrl":"10.1080/01616412.2024.2367936","url":null,"abstract":"Background: Early diagnosis of CH is a cornerstone and it is important to detect causes leading to diagnostic delay. Limited published data exist regarding CH in Egypt, and with no data showing characteristics of CH or causes of diagnostic delay .Aim: To investigate clinical characteristics, for CH and detect causes of diagnostic delay in Egypt.Methodology: A cross-sectional study was conducted including all patients (age: 18-60 years) with primary headache disorders in Egypt with CH patients consecutively recruited over 1 year. Demographic and clinical characteristics as well as rate of diagnostic delay were collected.Results: This registry included 1187 patients with primary headaches over a year. CH accounted for 1.9% . The majority of CH patients were males (82%), and a mean age of 37.9 ± 10 years. The mean age of disease onset was 25 ± 8 years. Sixty-five percent had episodic CH, while 34.8% had chronic CH. Most of the patients (95.7%) had strictly unilateral pain (right side 52.2%, left side 43.5%). Autonomic features were rhinorrhea (91%), ptosis (87%), and lacrimation (78%). Migrainous features were found in 26% of patients. Bout duration of CH lasted on an average of 1-4 months. Time interval of diagnostic delay ranged from 0.5 to 29 years, with a mean diagnostic delay of 9.8 ± 7.9 years.Conclusion: This study showed that CHs present 1.9% of primary headache disorders in Egypt, with males more affected than females. the incidence of smoking was higher among CH patients. Marked diagnostic delay was found which necessitate an action toward raising awareness.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"925-932"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting postoperative delirium after percutaneous transluminal angioplasty and stenting in patients with intracranial atherosclerotic stenosis. 颅内动脉粥样硬化性狭窄患者经皮腔内血管成形术和支架植入术后谵妄的预测。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-23 DOI: 10.1080/01616412.2024.2370730

Wanchun Zhu, Yiman Shen, Hua Zhao, Yinda Tang, Xuhui Wang, Shiting Li

{"title":"Predicting postoperative delirium after percutaneous transluminal angioplasty and stenting in patients with intracranial atherosclerotic stenosis.","authors":"Wanchun Zhu, Yiman Shen, Hua Zhao, Yinda Tang, Xuhui Wang, Shiting Li","doi":"10.1080/01616412.2024.2370730","DOIUrl":"10.1080/01616412.2024.2370730","url":null,"abstract":"Objective: Known as a major surgical complication, postoperative delirium (POD) has not been well studied in patients with intracranial atherosclerotic stenosis (ICAS). This study aimed to investigate the correlation between perioperative clinical characteristics and the occurrence of POD.Methods: Patients' demographic characteristics and perioperative testing data were collected. Binary logistic regression was conducted for assessing related risk factors. A nomogram was developed to predict the occurrence of POD after percutaneous transluminal angioplasty and stenting (PTAS) in patients with ICAS.Results: The occurrence of POD in this study was 30.67%. Among all the clinical and laboratory characteristics in patients, age (OR = 1.234, 95%CI = 1.004-1.517, p = 0.046), gender (OR = 5.676, 95%CI = 1.028-31.334, p = 0.046), preoperative MMSE scores (OR = 2.298, 95%CI = 1.005-5.259, p = 0.049), the degree of stenosis (OR = 6.294, 95%CI = 1.043-37.974, p = 0.045), operating time (OR = 1.088, 95%CI = 1.023-1.157, p = 0.006), and HbA1c levels (OR = 2.226, 95%CI = 1.199-4.130, p = 0.011) were the independent risk factors.Conclusion: Male patients with advanced-age, lower preoperative MMSE scores, severe stenosis, longer operating time, and higher HbA1c levels are closely related to POD after PTAS. Fully perioperative assessments may play an important role in predicting the occurrence of POD.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"956-964"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The additive effect between bupropion and citicoline upon induction of anti-nociceptive effect in nerve-ligated mice. 安非他酮和柠檬胆碱在诱导神经绑定小鼠抗痛觉效应时的相加效应。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-03 DOI: 10.1080/01616412.2024.2370203

Nastaran Raissi-Dehkordi, Bardia Hajikarimloo, Negar Raissi-Dehkordi, Fatemeh Khakpai, Mohammad-Reza Zarrindast

{"title":"The additive effect between bupropion and citicoline upon induction of anti-nociceptive effect in nerve-ligated mice.","authors":"Nastaran Raissi-Dehkordi, Bardia Hajikarimloo, Negar Raissi-Dehkordi, Fatemeh Khakpai, Mohammad-Reza Zarrindast","doi":"10.1080/01616412.2024.2370203","DOIUrl":"10.1080/01616412.2024.2370203","url":null,"abstract":"Objectives: Bupropion is an atypical antidepressant that shows robust efficacy in the regulation of neuropathic pain. Citicoline is a dietary supplement which is used as a neuroprotective agent for central nervous system (CNS) disorders. The probable interaction between bupropion and citicoline on neuropathic pain was assessed in male mice.Methods: Neuropathic pain was induced by sciatic nerve ligation. Neuropathic pain was examined in nerve-ligated mice using tail-flick and hot-plate tests.Results: The results indicated that intraperitoneal (i.p.) administration of citicoline (50 and 100 mg/kg) induced an anti-nociceptive effect in nerve-ligated animals. Similarly, i.p. injection of bupropion (2.5 and 5 mg/kg) induced anti-nociceptive effects in nerve-ligated mice. Co-administration of different doses of bupropion (2.5 and 5 mg/kg) along with a low dose of citicoline (25 mg/kg) caused an anti-nociceptive effect by enhancement of tail-flick and hot plate latencies. Interestingly, there is an additive effect between bupropion and citicoline upon the induction of the anti-nociceptive effect.Conclusions: Based on these results, it can be concluded that there is an interaction between bupropion and citicoline upon induction of an anti-nociceptive effect in nerve-ligated mice.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"939-946"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of ferroptosis on the in vitro OGD/R model in rat microglia. 铁蛋白沉积对大鼠小胶质细胞体外 OGD/R 模型的影响

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-16 DOI: 10.1080/01616412.2024.2370205

Tao Ye, Ning Zhang, Anbang Zhang, Xiuqi Sun, Bo Pang, Xuemei Wu

{"title":"The influence of ferroptosis on the in vitro OGD/R model in rat microglia.","authors":"Tao Ye, Ning Zhang, Anbang Zhang, Xiuqi Sun, Bo Pang, Xuemei Wu","doi":"10.1080/01616412.2024.2370205","DOIUrl":"10.1080/01616412.2024.2370205","url":null,"abstract":"Objective: We aimed to explore the influence of ferroptosis on an oxygen-glucose deprivation/reoxygenation (OGD/R) model in primary rat microglia.Methods: Primary microglia were extracted from rats and cultured in vitro. The cells were subjected to a hypoxic environment for 6 h in a glucose-free medium, and then re-oxygenated for 24 h in DMEM/F12. Rat microglia were pretreated with the ferroptosis activator erastin and the ferroptosis inhibitor ferrostatin 1 for 24 h, followed by detection of cell cycle progression and apoptosis by flow cytometry. Intracellular total iron levels were measured. In addition, the relative levels of reactive oxygen species (ROS), malondialdehyde (MDA), and superoxide dismutase (SOD) were determined using enzyme-linked immunosorbent assay. The protein levels of 15-lox2, GPX4, SLC7A11, ACSL4, and TFR1 were examined by western blotting.Results: Compared with rat microglia subjected to OGD/R, pretreatment with erastin did not influence cell apoptosis but significantly enhanced total iron levels, MDA, and ROS levels, whereas it reduced SOD levels. Moreover, it upregulated ACSL4, TFR1, and 15-lox2 and downregulated GPX4 and SLC7A11. Pretreatment with ferrostatin 1 significantly inhibited cell apoptosis and cell cycle arrest in the G0/G1 phase. It significantly reduced total iron levels, MDA, and ROS levels and enhanced SOD levels, which also downregulated ACSL4, TFR1, and 15-lox2, and upregulated GPX4 and SLC7A11.Conclusion: Our study showed that inhibition of ferroptosis is favorable against potential OGD/R-induced damage in rat microglia.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"947-955"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resection of meningiomas located in motor eloquent areas - comparative analysis of navigated transcranial magnetic stimulation and conventional neuronavigation. 位于运动区的脑膜瘤切除术--导航经颅磁刺激与传统神经导航的比较分析。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-07-02 DOI: 10.1080/01616412.2024.2370731

Thomas Eibl, Michael Schrey, Jakob Rossmann, Adrian Liebert, Leonard Ritter, Rüdiger Lange, Hans-Herbert Steiner, Karl-Michael Schebesch

{"title":"Resection of meningiomas located in motor eloquent areas - comparative analysis of navigated transcranial magnetic stimulation and conventional neuronavigation.","authors":"Thomas Eibl, Michael Schrey, Jakob Rossmann, Adrian Liebert, Leonard Ritter, Rüdiger Lange, Hans-Herbert Steiner, Karl-Michael Schebesch","doi":"10.1080/01616412.2024.2370731","DOIUrl":"10.1080/01616412.2024.2370731","url":null,"abstract":"Background: Navigated transcranial magnetic stimulation (nTMS) has been established as a preoperative diagnostic procedure in glioma surgery, increasing the extent of resection and preserving functional outcome. nTMS motor mapping for the resection of motor eloquent meningiomas has not been evaluated in a comparative analysis, yet.Methods: We conducted a retrospective matched-pair analysis for tumor location and size in meningioma patients with tumors located over or close to the primary motor cortex. Half of the study population received nTMS motor mapping preoperatively (nTMS-group). The primary endpoint were permanent surgery-related motor deficits. Additional factors associated with new motor deficits were evaluated apart from nTMS.Results: 62 patients (mean age 62 ± 15.8 years) were evaluated. 31 patients received preoperative nTMS motor mapping. In this group, motor thresholds (rMT) corresponded with tumor location and preoperative motor status, but could not predict motor outcome. No patient with preoperative intact motor function had a surgery-related permanent deficit in the nTMS group whereas four patients in the non-TMS group with preoperative intact motor status harbored from permanent deficits. 13 patients (21.3%) had a permanent motor deficit postoperatively with no difference between the nTMS and the non-TMS-group. Worsening in motor function was associated with higher patient age (p = 0.01) and contact to the superior sagittal sinus (p = 0.027).Conclusion: nTMSmotor mapping did not lead to postoperative preservation in motorfunction. nTMS data corresponded well with the preoperative motorstatus and were associated with postoperative permanent deficits if tumors were located over the motor hotspot according to nTMS.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"965-971"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0