Neurological Research最新文献_第8页

Awareness of risk factors for cerebrovascular diseases among acute ischemic stroke patients in Shenzhen, China. 中国深圳急性缺血性脑卒中患者对脑血管疾病危险因素的认识。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-26 DOI: 10.1080/01616412.2024.2381161

Shiyu Hu, Zhihao Lei, Yang Wang, Lijie Ren

{"title":"Awareness of risk factors for cerebrovascular diseases among acute ischemic stroke patients in Shenzhen, China.","authors":"Shiyu Hu, Zhihao Lei, Yang Wang, Lijie Ren","doi":"10.1080/01616412.2024.2381161","DOIUrl":"10.1080/01616412.2024.2381161","url":null,"abstract":"Background and purpose: Unawareness of the risk factors is one of the most important issues that need to be settled for stroke prevention. We aimed to evaluate the awareness of risk factors for cerebrovascular diseases (CVDs) among acute ischemic stroke patients and to investigate the characteristics of patients who were unaware of their risk factors in Shenzhen, China.Methods: Registered data on awareness of CVD risk factors of patients with confirmed acute ischemic stroke (AIS) from June 2020 to December 2022 were analyzed in May 2023. The data were extracted from the database of Shenzhen Quality Control Center for Management of Cerebrovascular Diseases.Results: Totally, there were 5147 AIS patients with complete data eligible for this study. AIS patients' awareness regarding existing hypertension, diabetes, dyslipidemia, and atrial fibrillation (AF) was 76.1%, 76.2%, 24.2%, and 53.4%, respectively. Patients who were lack of awareness of the CVD risk factors were more likely to be males, individuals with younger ages, and those without medical insurance or a CVD history.Conclusions: The overall awareness of the CVD risk factors was suboptimal among AIS patients in Shenzhen, especially for the existing dyslipidemia. The health education of AIS should be further improved in males as well as individuals without medical insurance or any CVD histories. Age was an independent factor associated with the lack of awareness of the CVD risk factors. The stroke screening program should be extended to younger people.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1046-1053"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exoskeleton-assisted upper limb rehabilitation after stroke: a randomized controlled trial. 外骨骼辅助中风后上肢康复：随机对照试验。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-26 DOI: 10.1080/01616412.2024.2381385

İrem Akgün, İlkşan Demirbüken, Eren Timurtaş, Mehmet Kutay Pehlivan, Ali Utku Pehlivan, Mine Gülden Polat, Gerard E Francisco, Nuray Yozbatiran

{"title":"Exoskeleton-assisted upper limb rehabilitation after stroke: a randomized controlled trial.","authors":"İrem Akgün, İlkşan Demirbüken, Eren Timurtaş, Mehmet Kutay Pehlivan, Ali Utku Pehlivan, Mine Gülden Polat, Gerard E Francisco, Nuray Yozbatiran","doi":"10.1080/01616412.2024.2381385","DOIUrl":"10.1080/01616412.2024.2381385","url":null,"abstract":"Objectives: The upper-limb exoskeleton training program which is repetetive and task-specific therapy can improve motor functions in patients with stroke. To compare the effect of an upper-limb exoskeleton training program with Bobath concept on upper limb motor functions in individuals with chronic stroke.Methods: Participants were randomly assigned to exoskeleton group (EG, n = 12) or to Bobath group (BG, n = 12). Interventions were matched in terms of session duration and total number of sessions and performed 2 times per week for 6-weeks. Primary outcome was Fugl-Meyer-Upper Extremity (FMA-UE). Secondary outcomes were Modified Ashworth Scale (elbow and wrist flexor muscles), Motor Activity Log-30 which is consist of two parts as an amount of use (AOU) and quality of movement (QOM), and The Nottingham Extended Activities of Daily Living (NEADL) index.Results: After 12-sessions of training, the mean (SD) FMA-UE score increased by 5.7 (2.9) in the EG, and 1.9 (1.5) points in the BG (p < .05). In total, 40% of participants (5/12) demonstrated a clinically meaningful improvement (≥5.25 points) in the FM-UE, while none of the participants reached MCID score in the bobath group. Changes in the AOU, QOM, and NEADL were significantly larger in the EG compared to BG (p < .05). 7/12 (58.33%) of participants for AOU and 5/12 (42%) of participants for QOM in the EG showed that clinically meaningful change. 5/12 of participants (42%) in the EG demonstrated ≥4.9-point increase in NEADL score.Discussion: High-intensity repetitive arm and hand exercises with an exoskeleton device was safe and feasible. Exoskeleton-assisted training demonstrated significant benefits in improving upper limb functions and quality of life in individuals after stroke.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1074-1082"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of world stroke campaign on stroke literacy and knowledge in Taiwan. 世界卒中运动对台湾卒中素养和知识的影响。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI: 10.1080/01616412.2024.2381159

Bing-Yan Jiang, Lung Chan, Hung-Chou Chen, Ka-Wai Tam, Tsan-Hon Liou, Reuben Escorpizo, Li-Fong Lin

{"title":"Effects of world stroke campaign on stroke literacy and knowledge in Taiwan.","authors":"Bing-Yan Jiang, Lung Chan, Hung-Chou Chen, Ka-Wai Tam, Tsan-Hon Liou, Reuben Escorpizo, Li-Fong Lin","doi":"10.1080/01616412.2024.2381159","DOIUrl":"10.1080/01616412.2024.2381159","url":null,"abstract":"Objectives: Stroke is a leading cause of death in Taiwan. Poor public knowledge of stroke may lead to delays in prehospital arrival, resulting in unfavorable prognoses. Studies have investigated public knowledge of stroke and highlighted the importance of stroke education, however, few such studies have been conducted in Taiwan. This study assessed the changes in public knowledge of stroke between 2012 and 2020 by conducting a survey during two World Stroke Day events. Furthermore, this study identified areas where educational efforts may have been insufficient.Materials & methods: Questionnaires were distributed to the participants of 2012 and 2020 World Stroke Day events in Taiwan. In total, 328 and 336 questionnaires were completed, respectively. Stroke literacy and knowledge were analyzed between 2012 and 2020. Data were analyzed using the chi-square test or independent t-test. p < 0.05 indicates statistical significance.Results: Hypertension was the most recognized risk factor for stroke in both years (p < 0.001), and recognition of most of the given risk factors significantly increased. In addition, recognition of more than half of the stroke warning signs significantly increased, awareness of the correct acute stroke response also increased (p < 0.001), and overall stroke literacy in Taiwan increased (p = 0.001).Conclusion: Stroke literacy and knowledge in Taiwan have improved significantly between 2012 and 2020, but many people still lack adequate stroke knowledge and awareness. Government health department must take this sort of intervention continually (campaigns) and novel approaches (e.g. board game…) to improve stroke literacy and knowledge in public health.Registration id: N202109072, approved by the Joint Institutional Review Board of Taipei Medical University on 2021/11/02.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1026-1036"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circ_0076490 silencing inhibits MAPK1 expression to decrease the proliferation and increase apoptosis of Jurkat cells by regulating miR-144-3p in myasthenia gravis. 在肌无力患者中，Circ_0076490沉默可通过调节miR-144-3p抑制MAPK1的表达，从而减少Jurkat细胞的增殖并增加其凋亡。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-08-29 DOI: 10.1080/01616412.2024.2394324

Qin Ye, Chengyao Gu, Wang Yan

{"title":"Circ_0076490 silencing inhibits MAPK1 expression to decrease the proliferation and increase apoptosis of Jurkat cells by regulating miR-144-3p in myasthenia gravis.","authors":"Qin Ye, Chengyao Gu, Wang Yan","doi":"10.1080/01616412.2024.2394324","DOIUrl":"10.1080/01616412.2024.2394324","url":null,"abstract":"Background: Myasthenia gravis (MG) is a both neuromuscular junction and antibody-mediated autoimmune disease, and its pathogenesis involves the regulation of circular RNAs (circRNAs). However, the role of circ_0076490 in MG and the underlying mechanism remain unknown.Methods: RNA levels of circ_0076490, microRNA-144-3p (miR-144-3p), and mitogen-activated protein kinase 1 (MAPK1) were detected by quantitative real-time polymerase chain reaction. Cell viability and proliferation were investigated by cell counting kit-8 and 5-Ethynyl-29-deoxyuridine assays, respectively. Cell cycle and apoptosis were assessed by flow cytometry analysis. The putative binding relationship of miR-144-3p and circ_0076490 or MAPK1 was predicted by circular RNA interactome and TargetScan online databases, respectively, and identified through dual-luciferase reporter assay and RNA pull-down assay.Results: We observed dramatic increases of circ_0076490 and MAPK1 expression and a decrease of miR-144-3p expression in the peripheral blood of MG patients in comparison with healthy controls. Reduced expression of circ_0076490 induced an inhibitory effect on the proliferation of Jurkat cells and a promoting effect on cell apoptosis. Additionally, miR-144-3p was identified as a target miRNA of circ_0076490, and its depletion attenuated circ_0076490 knockdown-mediated effects on the proliferation and apoptosis of Jurkat cells. MAPK1 was a target gene of miR-144-3p and its overexpression rescued decreased cell proliferation and increased cell apoptosis induced by miR-144-3p introduction. Furthermore, circ_0076490 regulated MAPK1 expression by interacting with miR-144-3p.Conclusion: Circ_0076490 knockdown inhibited proliferation and induced apoptosis of Jurkat cells through the regulation of the miR-144-3p/MAPK1 axis, providing potential targets for developing improved therapy of MG.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1083-1093"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury. YTHDF1（而非YTHDF3）的缺失可减少脑外伤后大脑和肠道的损伤。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI: 10.1080/01616412.2024.2381160

Wei Zhao, Ruzhi Li, Xiang Zhong, Peizan Huang

引用次数: 0

Acute effect of myofascial stretching exercise on spasticity, balance, ambulation status and mobility of posterior chain muscles in multiple sclerosis. 肌筋膜拉伸运动对多发性硬化症患者痉挛、平衡、行走状态和后链肌肉活动度的急性影响。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-10 DOI: 10.1080/01616412.2024.2377003

Hanife Abakay, M Fatih Yetkin, Hanife Doğan, Ayşe Güç, Havva Talay Çalış

{"title":"Acute effect of myofascial stretching exercise on spasticity, balance, ambulation status and mobility of posterior chain muscles in multiple sclerosis.","authors":"Hanife Abakay, M Fatih Yetkin, Hanife Doğan, Ayşe Güç, Havva Talay Çalış","doi":"10.1080/01616412.2024.2377003","DOIUrl":"10.1080/01616412.2024.2377003","url":null,"abstract":"Objective: To investigate the acute effect of myofascial stretching exercises on spasticity, balance, ambulation status and mobility of posterior chain muscles in multiple sclerosis.Method: The study was conducted as a randomised controlled experimental study. The study included a total of 80 individuals diagnosed with multiple sclerosis (MS) with a mean age of 43.5 ± 9.62 years (experimental group) and 41.4 ± 10.4 years (control group). All individuals were treated once and evaluated before and after the session. After recording the sociodemographic characteristics, spasticity assessment was performed with the Modified Ashword Scale (MAS), balance assessment with the Berg Balance Scale (BBS), ambulation status with the Timed Up and Go Test (TUG), and posterior chain muscle mobility (PCMM) with finger-to-ground distance measurement.Results: The TUG (time to complete the distance) measurements of the experimental group after treatment were lower than those of the control group (p < 0.05). The value of PCMM measurements of the experimental group before the treatment was lower than that of the control group (p < 0.001). The difference in positive increase in PCMM measurements in the experimental group was higher than that in the control group (p < 0.05). After the treatment, the MAS value in the left knee of the experimental group was lower than that of the control group (p < 0.05).Discussion: Myofascial stretching exercises applied to individuals with MS made an acute contribution to ambulation status and mobility of posterior chain muscles. There was no difference in the evaluation of spasticity and balance.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1018-1025"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and clinical correlates of nonmotor symptoms in Parkinson's disease in a tertiary health-care center in Turkey. 土耳其一家三级医疗保健中心帕金森病患者非运动症状的患病率和临床相关性。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1080/01616412.2024.2381162

H Onder, S Comoglu

{"title":"Prevalence and clinical correlates of nonmotor symptoms in Parkinson's disease in a tertiary health-care center in Turkey.","authors":"H Onder, S Comoglu","doi":"10.1080/01616412.2024.2381162","DOIUrl":"10.1080/01616412.2024.2381162","url":null,"abstract":"Objective: The objective was to determine the prevalence and clinical correlates of nonmotor symptoms in Parkinson's disease patients in movement disorders outpatient clinics.Methods: We enrolled all consecutive PD patients who visited our movement disorders outpatient clinics between January and December 2023; and agreed to participate in the study. In addition to the evaluation of demographic and clinical features, clinical scales, including the MDS-UPDRS, NMSS, and FOOGQ, were performed.Results: Overall, we enrolled 163 PD subjects with a mean age of 63.9 ± 10.4 (F/M = 27/136). The disease duration was 3.5 (20) y [median (range)]. The median score of the NMSS was 41 points. The NMSs burden levels were severe in 25.2%, and very severe in 25.2% of the subjects. The subitems with the highest scores were sleep/fatigue, mood/cognition, urinary, and miscellaneous. The analyses within the patient group with newly diagnosed PD also revealed high NMSS scores. Comparisons of the NMSS between distinct PD stages revealed greater NMSS scores in the severe stage than in the mild stage (p = 0.001). Correlation analyses between the clinical scores and the NMSS scores revealed positive correlations between the NMSS scores and the scores on all the clinical scales including the MDS-UPDRS 1-4, and FOGQ.Conclusion: We reported the first data regarding the NMS burden in PD patients from Turkey. We found a high prevalence and severity of various domains of NMSs, most of which were sleep/fatigue, mood/cognition, urinary, and miscellaneous. More than half of the patients had severe to very severe NMS burden. Although NMSs were more common severe-stage disease, they were also prevalent in the subgroup with newly diagnosed patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1054-1062"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors of cerebral aneurysms rupture in an Indonesian population. 印度尼西亚人口中脑动脉瘤破裂的风险因素。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-06 DOI: 10.1080/01616412.2024.2376308

Beny Rilianto, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Pratiwi Raissa Windiani, Kelvin Theandro Gotama, Muhammad Kusdiansah, Abrar Arham

{"title":"Risk factors of cerebral aneurysms rupture in an Indonesian population.","authors":"Beny Rilianto, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Pratiwi Raissa Windiani, Kelvin Theandro Gotama, Muhammad Kusdiansah, Abrar Arham","doi":"10.1080/01616412.2024.2376308","DOIUrl":"10.1080/01616412.2024.2376308","url":null,"abstract":"Background: The demographic, clinical, and angiographic features of ruptured aneurysms compared to unruptured cerebral aneurysms in Indonesia are still limited. This study aims to determine risk factors for rupture according to clinical patterns and morphological features in the Indonesian population.Method: We retrospectively reviewed all cerebral aneurysm registries at the largest comprehensive stroke center in Indonesia from January 2019 to January 2022. We compared demographic and vascular risk factors as well as angiographic features between patients with ruptured and unruptured aneurysms with univariate and multivariate analyses.Results: Of 275 patients, 231 (84%) had ruptured cerebral aneurysms. We found a significant difference between the ruptured and unruptured groups in variables such as age, hypertension, dyslipidemia, smoking, location, and type of aneurysm. It was found that only the anterior circulation site (OR 4.91, 95% CI 1.47-16.48; p < 0.01) and saccular type (OR 5.45, 95% CI 1.42-20.93; p = 0.01) were significantly linked to ruptured aneurysms.Conclusion: Our findings revealed that anterior location and saccular type were substantially linked with ruptured aneurysms in the Indonesian population.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"989-995"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

USP7 alleviates neuronal inflammation and apoptosis in spinal cord injury via deubiquitinating NRF1/KLF7 axis. USP7 通过去泛素化 NRF1/KLF7 轴减轻脊髓损伤中的神经元炎症和凋亡。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-11-01 Epub Date: 2024-07-15 DOI: 10.1080/01616412.2024.2376999

Qifei Xu, Fanguo Kong, Guanghui Zhao, Junwei Jin, Shengkai Feng, Ming Li

{"title":"USP7 alleviates neuronal inflammation and apoptosis in spinal cord injury via deubiquitinating NRF1/KLF7 axis.","authors":"Qifei Xu, Fanguo Kong, Guanghui Zhao, Junwei Jin, Shengkai Feng, Ming Li","doi":"10.1080/01616412.2024.2376999","DOIUrl":"10.1080/01616412.2024.2376999","url":null,"abstract":"Background: Ubiquitin-specific protease 7 (USP7) has been found to be associated with motor function recovery after spinal cord injury (SCI). Therefore, its role and mechanism in SCI process need further exploration.Methods: SCI rat models were established via performing laminectomy at the T9-T11 spinal vertebrae and cutting spinal cord tissues. SCI cell models were constructed by inducing PC12 cells with lipopolysaccharide (LPS). The protein levels of USP7, nuclear respiratory factor 1 (NRF1), Krüppel-like factor 7 (KLF7) and apoptosis-related markers were detected by western blot. Cell viability and apoptosis were tested by cell counting kit-8 assay and flow cytometry. The contents of inflammatory factors were examined using ELISA. The interaction between NRF1 and USP7 or KLF7 was analyzed by co-immunoprecipitation assay, chromatin immunoprecipitation assay and dual-luciferase reporter assay, respectively.Results: USP7 was downregulated in SCI rat models and LPS-induced PC12 cells. Overexpressed USP7 promoted viability, while repressed apoptosis and inflammation in LPS-induced PC12 cells. USP7 could stabilize NRF1 protein expression via deubiquitination, and NRF1 knockdown reversed the protective effect of USP7 against LPS-induced PC12 cell injury. NRF1 is bound to KLF7 promoter to enhance its transcription. NRF1 overexpression inhibited LPS-induced PC12 cell inflammation and apoptosis via increasing KLF7 expression.Conclusion: USP7 alleviated inflammation and apoptosis in LPS-induced PC12 cells via NRF1/KLF7 axis, indicating that targeting of USP7/NRF1/KLF7 axis might be a promising treatment strategy for SCI.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1008-1017"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No causal link between herpes zoster and ischemic stroke: evidence from Mendelian randomization study. 带状疱疹与缺血性中风之间没有因果关系：孟德尔随机研究的证据。

IF 1.7 4区医学

Neurological Research Pub Date : 2024-10-01 Epub Date: 2024-06-14 DOI: 10.1080/01616412.2024.2363098

Yao Wang, Peng Xu, Ke Wang, Xinchen Ji, Jing Lu, Tianying Chang, Baitong Wang, Dongmei Zhang, Xinzhi Chen, Jian Wang

{"title":"No causal link between herpes zoster and ischemic stroke: evidence from Mendelian randomization study.","authors":"Yao Wang, Peng Xu, Ke Wang, Xinchen Ji, Jing Lu, Tianying Chang, Baitong Wang, Dongmei Zhang, Xinzhi Chen, Jian Wang","doi":"10.1080/01616412.2024.2363098","DOIUrl":"10.1080/01616412.2024.2363098","url":null,"abstract":"Objective: The association between herpes zoster (HZ) and stroke has been the subject of much previous research. Nevertheless, the connection remains ambiguous. A two-sample Mendelian randomisation study was conducted to explore the potential causal link between HZ and ischaemic stroke, including its subtypes.Methods: For our MR analysis, we identified genetic instrumental variables related to both HZ and stroke by screening two prominent publicly accessible genome-wide association study databases. The primary approach involved using the inverse variance weighting method. To supplement this, we also employed methods such as MR-Egger regression, the weighted median approach, simple and weighted models. Lastly, to ascertain the stability and reliability of the results, we conducted tests for heterogeneity detection, horizontal pleiotropy assessment, and a leave-one-out analysis.Results: The genetically predicted HZ did not indicate an association with stroke risk ([OR] 1.041; 95% [CI] 0.958-1.131;p = 0.336). This lack of association also held true for different subtypes of stroke: ischaemic stroke (OR = 1.047, 95% CI = 0.955-1.148, p = 0.323), large vessel stroke (OR = 1.13, 95% CI = 0.90-1.41, p = 0.272), cardioembolic stroke (OR = 1.020, 95% CI = 0.859-1.211, p = 0.816), small vessel stroke (OR = 1.14, 95% CI = 0.93-1.40, p = 0.195), and lacunar stroke (OR = 1.195, 95% CI = 0.967-1.476, p = 0.097).Conclusion: This MR study showed that not uncover a causal link between herpes zoster and ischaemic stroke. Additional research will be necessary in the future to shed light on the fundamental mechanisms involved.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"907-916"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0