Neurological Research最新文献_第7页

U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline. 身体质量指数与脑出血相关功能下降呈u型关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1080/01616412.2025.2472843

Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa

{"title":"U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.","authors":"Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa","doi":"10.1080/01616412.2025.2472843","DOIUrl":"10.1080/01616412.2025.2472843","url":null,"abstract":"Background: Body mass index (BMI) is associated with the sites of intracerebral hemorrhage (ICH), which affect functional decline. However, the optimal BMI range for minimizing functional decline remains unclear. This study aimed to clarify the relationship between BMI and ICH-related functional decline.Methods: ICH survivors registered in the Japanese Registry Of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database from April 2016 to March 2020 were included. BMI was categorized according to the World Health Organization Asia-Pacific classification. The primary outcome was ICH-related functional decline, defined as an increase in the modified Rankin Scale (mRS) score at discharge compared to pre-stroke.Results: This study included 155,211 patients with ICH, with a mean BMI of 22.3 kg/m2. Among these patients, 74.1% experienced ICH-related functional decline. The overweight group (23.0 < BMI ≤ 25.0 kg/m2) exhibited the lowest rate of functional decline (Odds ratio: 0.90, 95% CI: 0.85-0.94). The relationship between BMI and ICH-related functional decline followed a U-shaped curve, indicating that a BMI range of 22.2-30.4 kg/m2 was associated with reduced odds of functional decline.Conclusion: In patients with ICH, both extremely low and high BMIs were associated with a higher likelihood of functional decline post-ICH onset. Maintaining a BMI within the range of 22.2-30.4 kg/m2 may be beneficial for reducing the risk of functional decline.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"296-305"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study. 血清神经丝轻链作为不宁腿综合征的潜在生物标志物：一项横断面研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1080/01616412.2025.2472836

Aysu Yetis, Asuman Celikbilek, Bilal Ilanbey, Naime Meric Konar, Selcen Duran

引用次数: 0

Investigating the role of the AMPK signaling pathway in preventing CCI-induced neuropathy in rats: focus on anti-inflammatory effects. 研究AMPK信号通路在预防cci诱导的大鼠神经病变中的作用：重点研究抗炎作用。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-28 DOI: 10.1080/01616412.2025.2486523

Amin Hasanvand, Maryam Ghandinezhad, Mohammadjavad Nourmohammadi, Fatemeh Hatami, Behrouz Beiranvand, Zahra Haghighatian, Peyman Amanolahi Baharvand, Ali Kharazmkia

{"title":"Investigating the role of the AMPK signaling pathway in preventing CCI-induced neuropathy in rats: focus on anti-inflammatory effects.","authors":"Amin Hasanvand, Maryam Ghandinezhad, Mohammadjavad Nourmohammadi, Fatemeh Hatami, Behrouz Beiranvand, Zahra Haghighatian, Peyman Amanolahi Baharvand, Ali Kharazmkia","doi":"10.1080/01616412.2025.2486523","DOIUrl":"https://doi.org/10.1080/01616412.2025.2486523","url":null,"abstract":"Objective: It has been shown that the AMPK signaling pathway helps maintain the structure of nerve cells and prevent damage caused by hypoxia by preserving the energy available in these cells. This signaling pathway is activated by various drugs, including metformin.Methods: In this study, thirty male rats were randomly divided into healthy rats, CCI (chronic constriction injury), CCI + metformin, CCI + dorsomorphin, and CCI + metformin + dorsomorphin groups. Behavioral tests were performed on the third, seventh, and fourteenth days after the induction of CCI. On the last day, the inflammatory cytokines and pathology were investigated after dissecting the spinal cords and sciatic nerves of the animals, respectively.Results: The results of this study indicated that metformin could improve performance in behavioral tests and reduce the levels of inflammatory cytokines. Histological analyses further revealed that metformin could decrease inflammation and necrosis in sciatic nerve tissue. Notably, this effect was observed despite dorsomorphin injection, which prevented the therapeutic effects of metformin in the fifth group.Conclusion: The results of this study indicated that stimulation of the AMPK signaling pathway could effectively preserve the structure of the sciatic nerve, reduce inflammation, and improve responses to behavioral tests.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical presentations of post ischemic and post traumatic brain injury scars associated seizures. 缺血性和创伤性脑损伤瘢痕相关癫痫发作的临床表现。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-25 DOI: 10.1080/01616412.2025.2482755

Vishal Chavda, Vimal Patel, Parmar Harisinh Vajesinh, Manuel De Jesus Encarnacion Ramirez, Gervith Reyes-Soto, Creed M Stary, Nicola Montemurro

{"title":"Clinical presentations of post ischemic and post traumatic brain injury scars associated seizures.","authors":"Vishal Chavda, Vimal Patel, Parmar Harisinh Vajesinh, Manuel De Jesus Encarnacion Ramirez, Gervith Reyes-Soto, Creed M Stary, Nicola Montemurro","doi":"10.1080/01616412.2025.2482755","DOIUrl":"https://doi.org/10.1080/01616412.2025.2482755","url":null,"abstract":"Objectives: Deep scarring inside the temporal lobe of the brain commonly causes focal seizures and structural epilepsy. Temporal herniation/protrusion including encephaloceles deduced by head and skull injury causes refractory epilepsy. In addition to debilitating seizures, epilepsy can cause cognitive and emotional problems with reduced quality of life.Methods: The major aim is to prevent the disorder in the first place: identify, detect, and reverse the processes responsible for its onset, and monitor and treat its progression.Results: Epilepsy often occurs following a latent period of months to years (epileptogenesis) because of brain insults, such as head trauma, stroke, or status epilepticus. Although this latent period clearly represents a therapeutic window, we are not able to stratify patients at risk for long-term epilepsy, which is prerequisite for preventative clinical trials. Moreover, because of the length of the latent period, an early biomarker for treatment response would be of high value. Finally, mechanistic biomarkers of epileptogenesis may provide more profound insight into the process of disease development.Discussion: This review discussed the pathophysiology associated with glial cells in scar epileptogenesis, neurological manifestations, clinical interventions, and current diagnostic and therapeutic approaches.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The correlation between vitamin B12 serum levels and migraine: a case-control study. 维生素B12血清水平与偏头痛的相关性：一项病例对照研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/01616412.2025.2462735

Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed

{"title":"The correlation between vitamin B12 serum levels and migraine: a case-control study.","authors":"Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed","doi":"10.1080/01616412.2025.2462735","DOIUrl":"10.1080/01616412.2025.2462735","url":null,"abstract":"Objectives: Migraine represents the prevailing form of primary headache with no fully described etiology and pathophysiology. This study aimed to assess the association between vitamin B12 serum levels and both chronic and episodic migraine.Patients and methods: This study was conducted as a case-control study, including 90 migraineurs, divided into 48 with episodic migraine and 42 with chronic migraine as the case group, and 90 matched healthy participants as the control group. The serum level of vitamin B12 was measured using enzyme-linked immunosorbent assay (ELISA) for all subjects. Its association with the Migraine Disability Assessment (MIDAS) scale and migraine attack severity, measured using the Visual Analog Scale (VAS), was analyzed.Results: Migraineurs exhibited a notable reduction in serum vitamin B12 levels compared to the control group (243.97 ± 124.85 pg/ml vs. 302.69 ± 143.69 pg/ml, p = 0.014). Furthermore, chronic migraine patients had significantly lower serum vitamin B12 levels when compared to episodic migraine patients (202.7 ± 75.62 pg/ml vs. 269.17 ± 143.31 pg/ml, p = 0.026). A significant negative correlation was found between serum vitamin B12 levels and the severity of migraine attacks, as measured by the VAS (r = -0.407, p = 0.036).Conclusion: The current study highlighted that vitamin B12 deficiency is highly associated with migraine and its severity. Further interventional research is highly recommended to investigate the potential causality of this association.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"195-200"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients. 轻度多发性硬化症患者膝关节屈伸肌同心及等距强度与姿势稳定性的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1080/01616412.2025.2462734

Seval Yilmaz, Nezehat Özgül Ünlüer

{"title":"The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients.","authors":"Seval Yilmaz, Nezehat Özgül Ünlüer","doi":"10.1080/01616412.2025.2462734","DOIUrl":"10.1080/01616412.2025.2462734","url":null,"abstract":"Background: Multiple sclerosis (MS) affects muscle strength and postural stability. However, the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS is not well known. The aim of the study was to examine the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS patients.Materials and methods: The study included 21 mild-stage MS patients with an EDSS score of 4 or less and 21 healthy controls. The concentric and isometric strength of knee flexors and extensors was measured with the Biodex System 4 Dynamometer, and postural stability with the Biodex Balance System under eyes-open and eyes-closed conditions on a rigid surface.Results: Mild-stage MS patients had reduced concentric strength of knee extensors and flexors and increased postural sway compared with healthy controls (p < 0.05). Isometric strength of knee extensors and flexors in mild stage MS patients were similar to healthy controls (p > 0.05). There was a moderate positive correlation between concentric strength of knee extensors and flexors and isometric strength of knee flexors and open-eye postural stability indexes in mild stage multiple sclerosis patients (p < 0.05).Conclusions: While isometric strength of knee extensors and flexors was preserved, concentric strength of knee extensors and flexors was decreased, and postural stability was adversely affected in mild stage MS patients. The increase in the strength of the knee muscles was associated with an increase in their postural sway in mild stage MS patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"188-194"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between the dynamics of red cell distribution width to lymphocyte ratio and clinical outcomes in patients with traumatic brain injury. 外伤性脑损伤患者红细胞分布宽度与淋巴细胞比值动态变化与临床预后的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1080/01616412.2025.2462732

Ehsan Alimohammadi, Elnaz Fatahi, Samira Shiri, Akram Amiri, Seyed Reza Bagheri

{"title":"The association between the dynamics of red cell distribution width to lymphocyte ratio and clinical outcomes in patients with traumatic brain injury.","authors":"Ehsan Alimohammadi, Elnaz Fatahi, Samira Shiri, Akram Amiri, Seyed Reza Bagheri","doi":"10.1080/01616412.2025.2462732","DOIUrl":"10.1080/01616412.2025.2462732","url":null,"abstract":"Background: Traumatic brain injury (TBI) is a major cause of morbidity and mortality, particularly among young individuals. This study investigates the correlation between the dynamic of Red Cell Distribution Width to Lymphocyte Ratio (RDWLR) and clinical outcomes in patients with moderate to severe TBI.Methods: A retrospective analysis was conducted on 405 consecutive patients with moderate to severe TBI admitted between July 2018 and July 2023. Clinical outcomes were assessed using the Glasgow Outcome Scale (GOS), categorized into favorable (GOS 4,5) and unfavorable outcomes (GOS 1,2,3). Data on demographics, clinical presentation, radiological findings, and laboratory tests were collected. Binary logistic regression analyzed the independent associations between variables, including changes in RDWLR over four days.Results: Among the 405 patients, 53.1% were male, with an average age of 33.21 years. ROC curve analysis identified a delta RDWLR threshold of 0.001. Of the patients, 67.1% had low delta RDWLR, while 33.8% had high delta RDWLR. Multivariate analysis showed that Glasgow Coma Scale (GCS) (OR 3.22; p < 0.001), light reflex (OR 1.87; p = 0.025), Rotterdam CT score (OR 2.33; p = 0.025), and change in RDWLR (OR 1.68; p = 0.031) were significantly associated with poor clinical outcomes.Conclusions: These findings suggest that delta RDWLR has potential as as a prognostic indicator of poor clinical outcomes in patients with moderate to severe traumatic brain injury (TBI), providing a cost-effective biomarker for clinical prognosis. However, further validation through prospective multicenter studies is needed.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"172-177"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD22 exacerbates brain injury in subarachnoid hemorrhage by inhibiting microglial phagocytic function. CD22通过抑制小胶质细胞吞噬功能加重蛛网膜下腔出血脑损伤。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-15 DOI: 10.1080/01616412.2025.2462731

Erliang Jin, Jing Han, Wanxi Pan, Longfei Yao, Lai Jiang, Hua Tang

{"title":"CD22 exacerbates brain injury in subarachnoid hemorrhage by inhibiting microglial phagocytic function.","authors":"Erliang Jin, Jing Han, Wanxi Pan, Longfei Yao, Lai Jiang, Hua Tang","doi":"10.1080/01616412.2025.2462731","DOIUrl":"10.1080/01616412.2025.2462731","url":null,"abstract":"Introduction: Subarachnoid hemorrhage (SAH) is a neurological emergency with a high mortality rate. The phagocytic and homeostatic functions of microglial cells play a crucial role after SAH. This study aims to investigate the mechanism of CD22-mediated abnormal microglial phagocytosis in brain injury caused by SAH.Materials and methods: BV2 microglial cells were exposed to 10 µM oxyhemoglobin for 24 hours to establish an in vitro SAH model. After CD22 knockdown, cell viability was assessed using the cell counting kit-8. The microglial phagocytic function was evaluated using pHrodo Red E.coli BioParticles and fluorescence microscopy. The expression levels of Kruppel-like factor 4 (KLF4), miR-150-3p, and CD22 were analyzed by real-time quantitative reverse transcription polymerase chain reaction and Western blot analysis. The binding relationship of KLF4 to the miR-150-3p promoter and the binding relationship of miR-150-3p to the CD22 3'UTR sequence were analyzed. Overexpression of KLF4 and inhibition of miR-150-3p in SAH cells were conducted to validate the mechanism.Results: SAH inhibited the microglial phagocytic function. CD22 was overexpressed in the SAH cell model. CD22 inhibition increased the microglial phagocytic function. miR-150-3p targeted and inhibited CD22 expression. Overexpression of miR-150-3p resulted in downregulation of CD22 and increased phagocytic function in microglial cells. KLF4 bound to the miR-150-3p promoter and promoted miR-150-3p expression. Overexpression of KLF4 reversed the inhibitory effect of miR-150-3p inhibition on phagocytic function in SAH cell model.Conclusion: KLF4 enhances the microglial phagocytic function in SAH by promoting miR-150-3p and inhibiting CD22.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"211-221"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative study of cognitive function and reaction time in obese and non-obese adults. 肥胖和非肥胖成人认知功能和反应时间的比较研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/01616412.2025.2462739

Hacı Ömer Yılmaz, Kezban Şahin, Hilal Ayvaz

{"title":"A comparative study of cognitive function and reaction time in obese and non-obese adults.","authors":"Hacı Ömer Yılmaz, Kezban Şahin, Hilal Ayvaz","doi":"10.1080/01616412.2025.2462739","DOIUrl":"10.1080/01616412.2025.2462739","url":null,"abstract":"Objective: Obesity may negatively affect the physical health and cognitive functions of individuals and delay their reaction time to stimuli. However, the association among obesity, cognitive functions, and reaction times is yet to be fully elucidated. The aim of this study was to assess the effect of obesity on cognitive functions and visual and auditory reaction times in adults.Methods: Data of 100 participants (50 obese and 50 normal) were analyzed in the study. Anthropometric parameters and 24-h dietary recall data were recorded. The Montreal Cognitive Assessment (MoCA) was used to evaluate the cognitive functions, Simple Reaction Time Task (SRTT)-Visual and SRTT-Auditory were used to assess visual and auditory reaction times of the participants, respectively.Results: The mean MoCA score of the obese was significantly lower than normal (17.46 and 25.22, respectively; p < 0.001). In addition, the mean auditory (p < 0.001) and visual (p < 0.05) reaction times of obese were significantly longer than normal. Similarly, this condition was also observed for the fastest and lowest values of auditory and visual reaction times. Additionally, obesity caused a decrease in the MoCA score (β = -0.762; p < 0.001) and delayed visual (β = 0.423; p < 0.001) and auditory (β = 0.590; p < 0.001) reactions. The negative effect of obesity was maintained after controlling for potential factors (MoCA, β = -0.594; p < 0.001; SRTT-Auditory, β = 0.409; p < 0.01; SRTT-Visual, β = 0.330; p < 0.05).Conclusion: Obese participants showed worse cognitive, auditory and visual performance. Additional research will be necessary in the future to shed light on the fundamental mechanisms involved.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"201-210"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of tranexamic acid against hydrogen peroxide-induced cytotoxicity on human neuroblastoma SH-SY5Y cells. 氨甲环酸抗过氧化氢诱导的人神经母细胞瘤SH-SY5Y细胞毒性的神经保护作用。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1080/01616412.2025.2462030

Ali Niapour, Yavar Mohebi, Hossein Ghalehnoei

{"title":"Neuroprotective effects of tranexamic acid against hydrogen peroxide-induced cytotoxicity on human neuroblastoma SH-SY5Y cells.","authors":"Ali Niapour, Yavar Mohebi, Hossein Ghalehnoei","doi":"10.1080/01616412.2025.2462030","DOIUrl":"10.1080/01616412.2025.2462030","url":null,"abstract":"Introduction: Tranexamic acid (TA) is an anticoagulant drug that is used worldwide. However, the adverse effects of TA may insult the nervous system. This study aimed to investigate the dual effects of TA on SH-SY5Y cells, including its detrimental and neuroprotective effects.Methods: SH-SY5Y cells were treated with various concentrations of TA and exposed to H2O2 for 24 hours. The neuroprotective effects of TA were evaluated in H2O2-challenged cells. To assess the neuroprotective effects of TA, SH-SY5Y cells were pretreated with TA for 12 hours and then exposed to H2O2 for 24 hours. Cell viability was assessed using the MTT assay. Flow cytometry was used to evaluate cellular apoptosis. The expression of Bax, Bcl-2, and Caspase-3 genes was analyzed by real-time PCR. Additionally, Akt phosphorylation was evaluated using western blotting.Results: At high concentrations, TA reduced cell viability and induced apoptosis by up-regulating BAX and Caspase-3 gene expression and down-regulating BCL-2 transcript. Furthermore, Akt phosphorylation was reduced following TA treatment. TA exhibited protective effects against H2O2-induced cell stress by down-regulating Bax and Caspase-3 gene expression, up-regulating Bcl-2 expression, and increasing the p-AKT/AKT ratio.Conclusion: Our findings demonstrated that TA exerts its neuroprotective effect at lower concentrations, but induces apoptosis in SH-SY5Y cells at high concentrations.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"163-171"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0