Neurological Research最新文献

{"title":"Deep cervical muscle endurance, trunk position sense, and swallowing performance in Parkinson's disease with temporomandibular disorder: a comparative study.","authors":"Melike Otlu, Ayşe Abit Kocaman, Mustafa Ertuğrul Yaşa","doi":"10.1080/01616412.2025.2528153","DOIUrl":"https://doi.org/10.1080/01616412.2025.2528153","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of temporomandibular disorder (TMD) among Parkinson's disease (PD) is relatively high, but deep cervical muscle endurance, trunk position sense, and swallowing performance in PD with TMD is still lacking. The aim of the study was to compare deep cervical flexor muscle endurance, trunk position sense and swallowing disorders in PD with and without TMD.</p><p><strong>Method: </strong>The study was conducted in 80 persons with PD. The patients were divided into two groups based on TMD. Trunk position sense was assessed with a digital inclinometer, temporomandibular joint dysfunction with 'Helkimo Clinical Craniomandibular Index', deep cervical muscle endurance with 'Cranio Cervical Flexor Test', and swallowing disorder with Eating Assessment Tool-EAT 10'. All patients were tested during the 'on' phase following drug therapy.</p><p><strong>Results: </strong>No significant differences were found in trunk position sense, deep cervical muscle endurance and swallowing performance between the groups (<i>p</i> > 0.0071).</p><p><strong>Conclusion: </strong>It was shown in the study that trunk position sense, deep cervical muscle endurance and swallowing performance didn't change in PD with TMD. The absence of significant differences in trunk position sense, deep cervical muscle endurance, and swallowing performance between the groups suggests that Temporomandibular dysfunction (TMD) appears not to impose further impact on these parameters in individuals diagnosed with Parkinson's disease.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The upregulation of caveolin-1 expression via the TLR4-Myd88 pathway contributes to cerebral vasospasm.","authors":"Quan Yan, Tai'an Fang, Xuefei Liu, Guojia Du","doi":"10.1080/01616412.2025.2491778","DOIUrl":"10.1080/01616412.2025.2491778","url":null,"abstract":"<p><p>Cerebral vasospasm (CVS) following subarachnoid hemorrhage (SAH) significantly impacts patient morbidity and mortality. This study aimed to investigate the role of the TLR4-MyD88 signaling pathway in the pathogenesis of CVS and its relationship with Caveolin-1 (CAV-1). We established a rat model of SAH using the double blood injection method in the cisterna magna to induce CVS. Various techniques, including pathological assessments, immunohistochemistry, Western blotting, and RT-qPCR, were employed to evaluate the expression of Toll-like receptor 4 (TLR4), MyD88, NF-κB, and CAV-1. The results showed a significant upregulation of TLR4, MyD88, NF-κB, and CAV-1 in SAH rats, with the upregulation correlating with CVS. Furthermore, the application of methyl-β-cyclodextrin (MβCD) effectively reduced CAV-1 expression and ameliorated CVS severity. Additionally, dexmedetomidine (DEX) treatment downregulated inflammatory markers and improved CVS, suggesting a potential therapeutic role through modulating the TLR4-MyD88 pathway. This study highlights the complex interplay between neuroinflammation, CAV-1, and CVS, proposing new avenues for therapeutic interventions in managing CVS post-SAH.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"594-603"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the causal association between coffee and migraine using Mendelian randomization analysis.","authors":"Ayin Chen, Liang Gao, Mozi Chen, Fujian Chen","doi":"10.1080/01616412.2025.2495931","DOIUrl":"10.1080/01616412.2025.2495931","url":null,"abstract":"<p><p><b>Background</b>: Migraine is a chronic neurological disorder influenced by various risk factors, including inadequate medication, anxiety, sleep disorders, depression, and stress-inducing events. Coffee is well-known for its diverse bioactive properties and may help relieve acute migraine symptoms; however, stopping long-term coffee consumption can unexpectedly trigger migraines. While some migraine sufferers view caffeine as a potential trigger, research suggests it may also have preventive effects. The complex physiological and pharmacological mechanisms behind coffee and its active components are not fully understood. <b>Objective</b>: This study aims to clarify the relationship between coffee consumption and its components and the risk of developing migraines.<b>Methods</b>: We conducted a Mendelian randomization (MR) analysis, using genetic variants as proxies for exposure to reduce confounding factors and biases.<b>Results</b>: Our results show a significant inverse relationship between coffee intake and migraine risk, consistent with previous epidemiological studies that indicate coffee may protect against headache disorders. The MR analysis also found that 7-methylxanthine is linked to a lower risk of migraines, while caffeic acid sulfate is associated with a higher risk. Sensitivity analyses showed no heterogeneity in SNP selection for all components, except for trigonelline, and both MR-Egger and MR-PRESSO tests did not indicate horizontal pleiotropy or outliers. Our research highlights the significant impact of coffee and its components on migraine risk, providing valuable dietary recommendations. The protective effect of coffee may be closely related to adenosine receptor antagonism, which warrants further investigation to better understand the underlying mechanisms.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"604-611"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JM-20 administration to animals with lesion of the nigrostriatal dopamine pathway induced by 6-hydroxydopamine, partially reverses motor damage and oxidative stress.","authors":"Luis Arturo Fonseca-Fonseca, Laura Reina Taño Portuondo, Jeney Ramírez-Sánchez, Nancy Pavón Fuentes, Abel Mondelo Rodríguez, Víctor Diogenes Amaral da Silva, Silvia Lima Costa, Yanier Núñez-Figueredo","doi":"10.1080/01616412.2025.2490089","DOIUrl":"10.1080/01616412.2025.2490089","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have shown that JM-20, a new chemical hybrid molecule, protects against rotenone and 6-hydroxydopamine (6-OHDA) neurotoxicity. Also, we demonstrated that JM-20 inhibit the formation of toxic alpha-synuclein aggregated species and aminochrome cytotoxicity.</p><p><strong>Objective: </strong>The present study sought to determine the neuroprotective property of JM-20 in animals with a partial lesion of the nigrostriatal dopamine pathway induced by 6-OHDA.</p><p><strong>Methods: </strong>For <i>in</i> <i>vivo</i> studies, adult male Wistar rats were lesioned in the right substantia nigra pars compacta (SNpc) with a 6-OHDA administration. Fifteen days after surgery, the animal's asymmetry levels were assessed. Those with asymmetry values higher than 50% were divided into two groups: animals that did not receive any treatment and those that were administered with JM-20 (40 mg/kg, intragastric via gavage) for 27 days. Every 7 days, the asymmetry values of the animals were analyzed until day 42 after the surgery. At the end of the experiment, the animals were euthanized, and the SNpc and striatum were taken out for the analysis of oxidative stress.</p><p><strong>Results: </strong>Our results reveal a behavioral function progressively recovered in the JM-20-treated animals, diminishing the percentage of motor asymmetry. Also, it improves some oxidative stress markers in the SNpc and the striatum of these animals.</p><p><strong>Conclusion: </strong>Our study provides the preclinical evidence to support the long-term neuroprotective potential of JM-20 in 6-OHDA hemiparkinson rat model, pointing out to its possible use as a disease-modifying agent in PD.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"557-566"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/01616412.2025.2492417","DOIUrl":"10.1080/01616412.2025.2492417","url":null,"abstract":"","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"i-ii"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle risk factors and stroke: findings from the national health and nutrition examination survey (1999-2020) and a Mendelian randomization analysis.","authors":"Xiaomin Feng, Zhangping He, Zuoyu Qin, Jing Lu, Chao Qin, Yanyan Tang","doi":"10.1080/01616412.2025.2490959","DOIUrl":"10.1080/01616412.2025.2490959","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the relationship between lifestyle risk factors and stroke, as well as to quantify causality, using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR).</p><p><strong>Methods: </strong>We analyzed data from 28,226 individuals who participated in NHANES between 1999 and 2020. To evaluate the association between lifestyle risk factors and stroke, we used weighted multivariate logistic regression. Genome-wide association study (GWAS) summary data were utilized to conduct bidirectional two-sample MR and multivariate MR analyses.</p><p><strong>Results: </strong>The NHANES observational study found that waist circumference, smoking, and creatinine were consistently and positively associated with stroke in multivariable-adjusted models, with odds ratios (OR) of 1.010 (95% confidence interval [CI], 1.001-1.019, <i>p</i> = 0.046), 1.653 (95% CI, 1.310-2.084, <i>p</i> < 0.001), and 1.400 (95% CI, 1.183-1.657, <i>p</i> < 0.001), respectively. Conversely, engaging in vigorous physical activities was a protective factor against stroke, with an OR of 0.572 (95% CI, 0.342-0.961, <i>p</i> = 0.037). Bidirectional two-sample and multivariate MR analyses revealed a causal link between smoking, waist circumference, and stroke (OR = 1.237, 95% CI, 1.130-1.354; OR = 1.239, 95% CI, 1.149-1.335, respectively).</p><p><strong>Discussion: </strong>Vigorous activities, especially fitness and recreational activities, serve as a protective factor against stroke. Smoking and increased waist circumference represent consistent lifestyle-related risk factors for stroke.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"582-593"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with seizure recurrence in patients undergoing repeat epilepsy surgery: a retrospective analysis.","authors":"Yue Hu, Guoqiang Chen, Yaoling Liu, Rui Zhang, Jianwei Chen, Junjian Zhou, Zhaozhao Zhang, Jianfei Hu, Qiang Liu, Guangming Zhang","doi":"10.1080/01616412.2025.2490090","DOIUrl":"10.1080/01616412.2025.2490090","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy surgery is a crucial intervention for cases of drug-resistant epilepsy, aiming to achieve seizure freedom. Despite significant success rates, some patients continue to experience seizures post-surgery, leading to the need for repeat interventions.</p><p><strong>Methods: </strong>This study employed a retrospective observational design, focusing on patients who underwent repeat epilepsy surgery at our hospital. All patients underwent standardized evaluations, including electroencephalography (EEG), magnetic resonance imaging (MRI), and, in select cases, positron emission tomography (PET) and invasive intracranial electrode monitoring.</p><p><strong>Results: </strong>In a retrospective analysis of 43 patients who underwent repeat epilepsy surgery, with an average follow-up of 43.95 months, 53.5% achieved favorable outcomes based on ILAE Class 1 or 2 criteria. Preoperative MRI indicating lesions was associated with a better prognosis, with an odds ratio (OR) of 0.049 (95% CI: 0.003 to 0.873, <i>p</i> = 0.040). Conversely, EEG showing multifocal epileptiform discharges predicted poorer outcomes, with an OR of 25.082 (95% CI: 1.726 to 364.533, <i>p</i> = 0.018). Surgical complications occurred in 30.2% of patients, with visual field defects, mild hemiparesis, and infections being the most common.</p><p><strong>Conclusions: </strong>A thorough assessment involving imaging, EEG, and invasive evaluation indicates that repeat epilepsy surgery is a safe and selective option for patients who have not achieved seizure freedom after initial resective surgery.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"567-577"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in use of gabapentinoids among adults in the United States from 2003-2018.","authors":"Hok Leong Chin","doi":"10.1080/01616412.2025.2490091","DOIUrl":"10.1080/01616412.2025.2490091","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the prevalence and trends in gabapentinoid use among the US population. It also aimed to contribute to the current literature by providing additional context across different sociodemographic subgroups.</p><p><strong>Methods: </strong>This study utilized data from the 2003-2004 cycles to the 2017-2018 cycles, including a total of 115,554 participants aged 20 years and older. Gabapentinoid use was determined through a questionnaire that inquired about prescription medication use during the past 30 days. Analyses were weighted and conducted using STATA/SE version 17.0. Trends were assessed using logistic regression.</p><p><strong>Results: </strong>Gabapentinoid use significantly increased from 0.6% (95% CI, 0.4%-0.7%) in 2003-2004 to 1.8% (95% CI, 1.6%-2.0%) in 2017-2018, primarily driven by increased gabapentin utilization. The trends were similar across different subgroups.</p><p><strong>Conclusions: </strong>The findings revealed a substantial rise in gabapentinoid use, particularly gabapentin, aligned with other studies. Safety concerns are underscored, emphasizing the potential for abuse and misuse, especially amid the opioid epidemic.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"578-581"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the single- and dual-task Figure-of-8 Walk tests in stroke patients.","authors":"Emel Taşvuran Horata, Güzin Kara Çakıcı, Zeynep Arıkan, Fatma Eken, Emre Baskan, Suat Erel","doi":"10.1080/01616412.2025.2495939","DOIUrl":"10.1080/01616412.2025.2495939","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the validity and reliability of the single- and dual-task Figure-of-8 Walk (F8W) tests in stroke patients.</p><p><strong>Methods: </strong>Thirty-two patients aged 61.09   ±   9.27 years (mean) were enrolled. The general cognitive function and stroke severity were assessed using the Standardized Mini Mental Test and National Institutes of Health Stroke Scale, respectively. The single- and dual-task F8W tests were performed in the study. The F8W test with a cognitive task of counting backward by threes (F8W  +  cog), and the F8W test with a motor task of carrying a glass of water on a tray (F8W  +  mot) consisted dual-task F8W. Relative and absolute reliability was assessed using the test-retest method and Bland-Altman plots. Intraclass correlation coefficients (ICC) and standard error of measurement (SEM) values were calculated. To assess convergent validity, the Timed Up and Go Test (TUGT), the 10-Meter Walk Test (10mWT), the Modified Four-Square Step Test (mFSST), and the Six-Spot Step Test (SSST) were administered.</p><p><strong>Results: </strong>The test-retest reliability of the F8W, F8W  +  cog, and F8W  +  mot tests demonstrated excellent results, with ICC values of 0.938, 0.929, and 0.935, respectively, and SEM values of 4.57, 5.52, and 5.01. Bland-Altman plots demonstrated that the F8W, F8W  +  cog, and F8W  +  mot were quite compatible with all tests (<i>p</i> > 0.99). All F8W tests were moderate to very strong correlation with the TUGT, 10mWT, mFSST, and SSST (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>The single- and dual-task F8W tests are useful reliable and valid tests in stroke patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"637-645"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and prognostic clinical factors of anti-gamma-aminobutyric acid-B receptor (GABAB-R) encephalitis in Türkiye: a multicenter study.","authors":"Rabia Gokcen Gozubatik-Celik, Betul Baykan, Ahmed Serkan Emekli, Erdem Tuzun, Aysun Soysal, Cihat Uzunkopru, Demet Ilhan Algın, Erol Comruk, Elif Şanlı, Fatma Akkoyun Arıkan, Hasmet Hanagası, Murat Kürtüncü, Ozdem Erturk Cetin, Sibel Velioglu, Tuba Cerrahoglu Sirin, Ulgen Yalaz Tekan, Vildan Yayla, Vedat Cilingir, Vuslat Yılmaz, Zeliha Basturk Ayhan, Murat Terzi","doi":"10.1080/01616412.2025.2495932","DOIUrl":"10.1080/01616412.2025.2495932","url":null,"abstract":"<p><strong>Introduction: </strong>GABAB-R encephalitis is a rare recognized autoimmune disease. This study investigates the clinical and laboratory features, treatment response, prognosis, and malignancy associations in GABAB-R encephalitis.</p><p><strong>Methods: </strong>We included consecutive encephalitis patients with GABAB-R autoantibodies and retrospectively analyzed their clinical data, neuroimaging, EEG findings, seizure characteristics, treatment responses, prognosis, and cancer presence. Prognosis was classified using the final Modified Rankin Score (mRS), with mRS > 2 indicating poor prognosis.</p><p><strong>Results: </strong>There were 17 patients with GABAB-R antibodies (12 males). The mean age at onset was 61.29 (range: 37-86), and the mean follow-up was 20.3 months (range: 6-60). The most common findings at onset were seizures, observed in 10 patients (58.8%), which increased to 13 patients (76.5%) during follow-up, psychiatric symptoms in 35.3%, and hyponatremia in 35.3%. Ten patients required intensive care unit (ICU) admission, and 11 patients had an underlying malignancy, predominantly lung cancer. Additionally, one patient had CASPR2 antibodies, and another had AMPA-R antibodies. Lesion probability map analysis revealed predominant involvement of the bilateral mesiotemporal regions. Patients with a final modified Rankin Scale Score greater than 2 (<i>n</i> = 10) exhibited a higher prevalence of psychiatric symptoms, ICU admission, and hyponatremia. Of the 12 patients on anti-seizure medications, only 8 achieved seizure-free status during follow-up. Those with a paraneoplastic etiology were more likely to present with psychiatric symptoms. Mortality, which occurred in 7 patients, was associated with persistent seizures (4/4 vs 3/10; <i>p</i> = 0.015) and ICU admission (7/7 vs 3/10 <i>p</i> = 0.010) Patients with both serum and CSF antibody positivity showed trends towards exhibiting higher rates of lung cancer and mortality.</p><p><strong>Discussion: </strong>Male gender and seizures are common in GABAB-R encephalitis, which also displays high malignancy and mortality rates. Remarkable prognostic factors include psychiatric symptoms, seizures, malignancy, and hyponatremia. 4(23%) of 17 patients with GABA-B receptor antibody encephalitis experience persistent seizures during follow-up.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"612-625"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}