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The effect of eight weeks of aerobic training with vitamin C on some apoptotic markers in the hippocampus tissue of rats with Alzheimer's disease; an experimental study. 8周维生素C有氧训练对阿尔茨海默病大鼠海马组织部分凋亡标志物的影响一项实验性研究。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-02-01 Epub Date: 2025-01-04 DOI: 10.1080/01616412.2024.2448624
Azadeh Farzi, Amin Teymoor Davani, Asiye Seyed, Omidreza Salehi, Zahra Mosallanezhad
{"title":"The effect of eight weeks of aerobic training with vitamin C on some apoptotic markers in the hippocampus tissue of rats with Alzheimer's disease; an experimental study.","authors":"Azadeh Farzi, Amin Teymoor Davani, Asiye Seyed, Omidreza Salehi, Zahra Mosallanezhad","doi":"10.1080/01616412.2024.2448624","DOIUrl":"10.1080/01616412.2024.2448624","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to investigate the effect of eight weeks of aerobic training (AT) and vitamin C supplementation (VC) on apoptotic markers in hippocampus tissue of AD rats treated with trimethyltin (TMT).</p><p><strong>Materials and methods: </strong>In this experimental study, 32 Sprague- Dawley rats (mean age: 14-18 months and mean weight 270-320 g) were treated with (10 mg/kg) TMT and divided into 4 groups including: 1) ADcontrol, 2) VC, 3) AT and 4) AT+VC groups. In order to investigate the effects of AD induction on research variables, 8 healthy rats selected as healthy control group (HC). Groups 3 and 4 trained for eight weeks, three sessions per week and each session lasted 15-48 minutes with an intensity of 10-24 m/min. Groups 2 and 4 received 4 mg/kg VC orally. One-way ANOVA with Tukey's <i>post- hoc</i> tests were used for statistical analysis of data (<i>p</i> ≤ 0.05).</p><p><strong>Results: </strong>The gene expression levels of Caspase 3, FasL, Cyt-C and AP-1 in the AT, VC and AT+VC groups were significantly lower than TMT group (<i>p</i> ≤ 0.05); Caspase 3, FasL and Cyt-C levels were significantly lower in the AT+VC group compare to VC and ET groups (<i>p</i> ≤ 0.05). CytC levels in AT group were significantly lower than VC group (<i>p</i> = 0.002). Also, AP-1 levels in AT+VC group were significantly lower than AT group (<i>p</i> = 0.01).</p><p><strong>Conclusions: </strong>It seems that AT and VC, both alone and interactively, can probably induce their anti-apoptotic effects in the hippocampus tissue of rats with AD via a common signaling pathway.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"77-86"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of D-dimer/fibrinogen ratio and combination of D-dimer and fibrinogen with prognosis of stroke and stroke subtypes. d -二聚体/纤维蛋白原比值及d -二聚体与纤维蛋白原联合与脑卒中及脑卒中亚型预后的关系
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-02-01 Epub Date: 2024-12-31 DOI: 10.1080/01616412.2024.2448630
Yun Zhai, Mengmeng Huo, Yue Liu, Hongwei Sun, Yanyan Sun, Fang Li, Hongwei Sun, Ying Tang
{"title":"Association of D-dimer/fibrinogen ratio and combination of D-dimer and fibrinogen with prognosis of stroke and stroke subtypes.","authors":"Yun Zhai, Mengmeng Huo, Yue Liu, Hongwei Sun, Yanyan Sun, Fang Li, Hongwei Sun, Ying Tang","doi":"10.1080/01616412.2024.2448630","DOIUrl":"10.1080/01616412.2024.2448630","url":null,"abstract":"<p><strong>Objective: </strong>Here, we aim to investigate whether D-dimer (DD)/fibrinogen (FIB) ratio or combination of DD and FIB contribute to the prognosis of stroke and stroke subtypes.</p><p><strong>Methods: </strong>1413 patients with acute ischemic stroke (AIS) were recruited. We measured DD and FIB levels on admission and followed up with patients at discharge and 90-day following discharge. We analyzed the association between DD/FIB ratio and poor function outcome of AIS and different AIS subtypes. Similarly, logistic regression model was used to estimate the combined effect of DD level and FIB level on the poor outcomes of stroke and stroke subtypes.</p><p><strong>Results: </strong>The patients with DD+FIB+ or high DD/FIB ratio tended to have the high risk of severe neurological deficits at both discharge and 90-day following discharge. In the subgroup analysis, high DD/FIB ratio was significantly associated with the poor function outcome in cardioembolism (CE) and large-artery atherosclerosis (LAA) subtypes. DD+FIB+ was strongly associated with the poor function outcome in CE subtype at discharge and 90-day.</p><p><strong>Conclusion: </strong>DD/FIB ratio and combination of DD and FIB may have more significant prognostic value of stroke and stroke subtypes than either index of DD or FIB alone in AIS patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"96-104"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global trends and hot spots in cerebral venous sinus thrombosis research over the past 50 years: a bibliometric analysis. 过去 50 年脑静脉窦血栓研究的全球趋势和热点:文献计量分析。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI: 10.1080/01616412.2024.2430999
Fatma Yardibi, Seden Demirci
{"title":"Global trends and hot spots in cerebral venous sinus thrombosis research over the past 50 years: a bibliometric analysis.","authors":"Fatma Yardibi, Seden Demirci","doi":"10.1080/01616412.2024.2430999","DOIUrl":"10.1080/01616412.2024.2430999","url":null,"abstract":"<p><strong>Background: </strong>Cerebral venous sinus thrombosis (CVST) is an uncommon form of cerebrovascular disease. Although our understanding of CVST has improved significantly over the past decades, there has been no bibliometric analysis of CVST until now. We aimed to examine and visualize the hotspots and trends of the research related to CVST using a bibliometric analysis based on Citespace and provide new insights for scholars in their future researches in this area.</p><p><strong>Methods: </strong>The literature on CVST was collected from the Web of Science Core Collection database. Bibliometric analysis was performed using CiteSpace (6.2.R3) Advanced software.</p><p><strong>Results: </strong>A total of 2396 articles were included in the analysis. Publications regarding CVST have increased over time. U.S.A. contributed the most articles. Ferro JM had the highest number of published papers. Stroke was the journal with the most publications and the most commonly cited journal. Nine out of the top 10 cited journals belong to Q1. The risk factors for CVST, emerging and current treatment of CVST, and CVST related to COVID-19 and COVID-19 vaccines are the major potential research hot spots and trends.</p><p><strong>Conclusions: </strong>CVST is a rapidly expanding research area and has received increasing attention by the researchers. Our study can provide researchers valuable information on the current status and trends in this area and guide for future studies.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"23-34"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curcumin ameliorates aluminum oxide nanoparticle-induced memory deficit by regulating the hippocampal p38 signaling pathway in mice. 姜黄素通过调节小鼠海马p38信号通路改善氧化铝纳米粒子诱导的记忆缺陷
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1080/01616412.2024.2430998
Roksana Soukhaklari, Fatema Pirsalami, Leila Moezi, Maryam Moosavi
{"title":"Curcumin ameliorates aluminum oxide nanoparticle-induced memory deficit by regulating the hippocampal p38 signaling pathway in mice.","authors":"Roksana Soukhaklari, Fatema Pirsalami, Leila Moezi, Maryam Moosavi","doi":"10.1080/01616412.2024.2430998","DOIUrl":"10.1080/01616412.2024.2430998","url":null,"abstract":"<p><strong>Objectives: </strong>Exposure to aluminum (Al) has been shown to be strongly associated with the pathogenesis of Alzheimer's disease (AD). Recent evidence indicates that the toxicity of Al nanoparticle (Al-NP) is far greater than Al itself due to its particle size. Epidemiological studies suggest that curcumin lower the prevalence of AD. MAPKs (ERK, p38 and JNK) were suggested to be involved in AD pathology and memory impairment. The present study aimed to evaluate if curcumin has the ability to protect against behavioral deficits induced by subcutaneously administered Al-NP in mice. Furthermore, the levels of phosphorylated and total hippocampal MAPKs were assessed using western blottechnique.</p><p><strong>Methods: </strong>Al-NP (10 mg/kg/s.c.) was administered to adult male NMRI mice for 10 days with or without curcumin in doses of 2.5 or 25 mg/kg/oral gavage). Memory was assessed using passive avoidance apparatus and anxiety-like behavior was evaluated using elevated plus maze. Following the behavioral tasks, western blot analysis was performed on the hippocampal tissues to detect the levels of phosphorylated and total MAPKs.</p><p><strong>Results: </strong>The results revealed that Al-NP deteriorated memory with no significant effect on anxiety-like behaviors. Additionally, it activated hippocampal p38 signaling pathway with no effect on ERK and JNK. Curcumin treatment at the dose of 25 mg/kg restored memory and p38 activation.</p><p><strong>Discussion: </strong>This study suggests that subcutaneous Al-NP administration impairs memory and hippocampal p38 signaling with no effect on ERK and JNK. Co-administration of curcumin restored Al-NP induced memory impairment and hippocampal p38 phosphorylation.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"15-22"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemogram and inflammatory indices in pain-free periods in migraine patients without aura. 无先兆偏头痛患者无痛期的血象和炎症指标。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1080/01616412.2024.2438616
Hatice Ferhan Kömürcü, Ceren Erkalaycı, Eren Gozke
{"title":"Hemogram and inflammatory indices in pain-free periods in migraine patients without aura.","authors":"Hatice Ferhan Kömürcü, Ceren Erkalaycı, Eren Gozke","doi":"10.1080/01616412.2024.2438616","DOIUrl":"10.1080/01616412.2024.2438616","url":null,"abstract":"<p><strong>Objectives: </strong>Since neurogenic inflammation and hemoconcentration have a prominent role in the pathophysiology of migraine, evaluation of hemogram parameters and indices showing inflammation can yield important information. In this study, we have investigated blood cell counts and ratios, systemic inflammation index (SII), systemic inflammation response index (SIRI) and red cell index (RCI) in the painless periods between pain attacks in patients with episodic migraine without aura.</p><p><strong>Methods: </strong>Hemogram data of both 309 patients diagnosed with migraine without aura related to pain-free periods and 199 healthy individuals were retrospectively retrieved from hospital records. Data related to erythrocyte, leukocyte, lymphocyte, platelet, monocyte, eosinophil counts; hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio (MLR), and neutrophil/monocyte ratio, SII, SIRI and RCI values were scanned to reveal intergroup differences in terms of these parameters.</p><p><strong>Results: </strong>A comparison of laboratory parameters revealed that certain indices differed significantly between the migraine and control groups. MLR (<i>p</i> = 0.005) and RDW (<i>p</i> < 0.001) values were significantly lower, while platelet (<i>p</i> = 0.016), MPV (<i>p</i> < 0.001) and hematocrit (<i>p</i> = 0.014) were significantly higher in the migraine patient group compared to the control group. There was no significant difference between the two groups regarding other parameters.</p><p><strong>Discussion: </strong>Higher hematocrit, platelet, mean platelet volume and lower monocyte/lymphocyte ratio values in this study support that hemoconcentration and chronic inflammation persist even in the absence of pain attacks in migraine patients without aura.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"44-50"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between Toll-like receptor 4 Asp299Gly polymorphism and susceptibility to intracranial aneurysm among male and female patients within the North Indian population. 北印度人群中toll样受体4 Asp299Gly多态性与男性和女性颅内动脉瘤易感性之间的关系
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1080/01616412.2024.2438617
Anjali Singh, Ved Prakash Maurya, Ritu Dewangan, Mayank Singh, Arun Kumar Srivastava, Alok Kumar
{"title":"Associations between Toll-like receptor 4 Asp299Gly polymorphism and susceptibility to intracranial aneurysm among male and female patients within the North Indian population.","authors":"Anjali Singh, Ved Prakash Maurya, Ritu Dewangan, Mayank Singh, Arun Kumar Srivastava, Alok Kumar","doi":"10.1080/01616412.2024.2438617","DOIUrl":"10.1080/01616412.2024.2438617","url":null,"abstract":"<p><strong>Objectives: </strong>Intracranial aneurysms (IA), often remain asymptomatic until they get ruptured, invariably leads to subarachnoid hemorrhage (SAH), and is influenced by both genetic and environmental factors. Recent studies indicated inflammation as a key player in IA development. This study delves into genetic variations within inflammatory pathways, focusing on TLR4-mediated cytokine release as potential IA biomarkers.</p><p><strong>Methods: </strong>Eighty IA patients and eighty healthy controls from North India participated, and demographic and clinical data were analyzed, including gender-stratified comparisons of TLR4 Asp299Gly genotype and TLR4 expression. Histological and molecular analyses of blood and brain tissue were done using SEM imaging, qPCR, and western blot.</p><p><strong>Results: </strong>Our result revealed elevated TLR4 expression in IA patients, with SEM imaging indicating intracerebral damage. TLR4 Asp299Gly heterozygote genotype was less prevalent in IA patients, suggesting a protective effect against IA development. Moreover, TNF-α levels were significantly higher in IA patients, indicating an inflammatory response. Further, TNF-α expression was downregulated in heterozygous patients, suggesting TLR4 Asp299Gly gene polymorphism affects the activation of TNF-α expression. Gender-based analysis between control and aneurysm cases showed a decrease in TLR4 Asp299Gly heterozygote genotype with heightened TLR4 expression and neurological deficits in IA female patients compared to males.</p><p><strong>Conclusions: </strong>This study highlights the association between TLR4 Asp299Gly genotype and IA susceptibility in North Indian populations, linking increased TLR4 expression to IA pathogenesis. Gender-specific disparities in TLR4 genotype and expression underscore the need for personalized treatment strategies, with TLR4 signaling modulation emerging as a promising therapeutic avenue warranting further investigation.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"51-62"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-363-5p protects from neuropathic pain in chronic constriction injury (CCI) rat models and regulates Schwann cell injury via negatively modulating SERPING1. miR-363-5p在慢性收缩损伤(CCI)大鼠模型中保护神经性疼痛,并通过负调节SERPING1调节雪旺细胞损伤。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1080/01616412.2024.2438613
Huihui Wu, Liang Zhu, Xia Geng, Xiaona Guo, Tingting Wang, Jingjing Xu, Linkai Jiang, Weibo Zhang
{"title":"miR-363-5p protects from neuropathic pain in chronic constriction injury (CCI) rat models and regulates Schwann cell injury via negatively modulating SERPING1.","authors":"Huihui Wu, Liang Zhu, Xia Geng, Xiaona Guo, Tingting Wang, Jingjing Xu, Linkai Jiang, Weibo Zhang","doi":"10.1080/01616412.2024.2438613","DOIUrl":"10.1080/01616412.2024.2438613","url":null,"abstract":"<p><strong>Objectives: </strong>Due to the complex and unclear pathogenesis of neuropathic pain, there is a lack of effective therapeutic strategy. miR-363-5p was considered of great potential in mediating the development of neuropathic pain, which has not been confirmed with direct evidence. This study evaluated the role of miR-363-5p in neuropathic pain with animal and cell models, aiming to reveal the potential of miR-363-5p in target therapy of neuropathic pain.</p><p><strong>Methods: </strong>Chronic constriction injury (CCI) rat models were established as the neuropathic pain model. The expression of miR-363-5p and its target was evaluated by PCR. The painology behaviors were evaluated to assess the function of miR-363-5p. Schwann cells were induced with LPS mimicking cell injury during neuropathic pain. Inflammation and cell growth were estimated by ELISA and CCK8 assays.</p><p><strong>Results: </strong>Significant downregulation of miR-363-5p and upregulation of SERPING1 were observed in CCI rats. miR-363-5p negatively regulated SERPING1 in CCI rats and LPS-induced Schwann cells. Overexpressing miR-363-5p could improve pain threshold and alleviate inflammation in CCI rats. It also a ttenuated LPS-induced inflammation and reduced proliferation in Schwann cells. The overexpression of SERPING1 could reverse the protective effect of miR-363-5p on CCI rats and LPS-induced Schwann cell injury.</p><p><strong>Conclusion: </strong>miR-363-5p protected from neuropathic pain via alleviating Schwann cell injury by negatively modulating SERPING1.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"35-43"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of galcanezumab for cluster headache preventive treatment: a systematic review and meta-analysis. galcanezumab用于丛集性头痛预防治疗的有效性和安全性:一项系统回顾和荟萃分析。
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1080/01616412.2024.2440022
Marina Barbosa da Silva, Domênica Baroni Coelho de Oliveira Ferreira, Cristian D Mendieta, Hamilcar Pereira da Silva, Lívia Aguiar Nogueira-Rosa, Nathalia Moraes-Figueiredo
{"title":"Efficacy and safety of galcanezumab for cluster headache preventive treatment: a systematic review and meta-analysis.","authors":"Marina Barbosa da Silva, Domênica Baroni Coelho de Oliveira Ferreira, Cristian D Mendieta, Hamilcar Pereira da Silva, Lívia Aguiar Nogueira-Rosa, Nathalia Moraes-Figueiredo","doi":"10.1080/01616412.2024.2440022","DOIUrl":"10.1080/01616412.2024.2440022","url":null,"abstract":"<p><strong>Background: </strong>Galcanezumab is a monoclonal antibody targeting the CGRP pathway and represents the latest disease-specific and mechanism-based therapeutic option for cluster headache (CH).</p><p><strong>Objective: </strong>We performed a systematic review and meta-analysis to evaluate the efficacy and safety of galcanezumab for CH.</p><p><strong>Methods: </strong>We searched PubMed, Embase, and Cochrane Library for studies implementing galcanezumab for episodic and chronic CH. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Reporting Guidelines for Meta-analyses of Observational Studies (MOOSE) guidelines. The primary outcome was efficacy, defined by a reduction from the baseline of at least 50% in the weekly frequency of CH attacks and the Patient Global Impression of Improvement scale (PGI-I). Secondary outcomes included treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs).</p><p><strong>Results: </strong>A total of 504 patients were included from 6 studies, of which 2 were RCTs. The follow-up period ranged from 3 weeks to 15 months. The mean age was 44.4 ± 10.2 years, with 24.4% female patients. Overall efficacy was 76.0% (95% CI 0.67-0.85), TEAEs were observed in 48.0% of patients (95% CI 0.25-0.72), and the most common were nasopharyngitis, local injection pain, and local injection swelling. TEAEs were, however, considerably higher within the 300 mg dose group compared with the 240 mg dose group, 80.0% (95% CI 0.65-0.87) versus 28.0% (95% CI 0.12-0.47), respectively.</p><p><strong>Conclusion: </strong>This meta-analysis suggests that galcanezumab is effective in reducing the number of CH attacks and can be considered a safe medication.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"63-76"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Auditory evoked brainstem responses and medial olivocochlear efferent system in migraine patients with phonophobia. 偏头痛患者的听觉诱发脑干反应和橄榄耳内侧传出系统
IF 1.7 4区 医学
Neurological Research Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1080/01616412.2024.2430994
Emre Soylemez, Aydın Sinan Apaydin, Tugce Gurel Soylemez, Borna Farhoomand, Dursun Ceylan
{"title":"Auditory evoked brainstem responses and medial olivocochlear efferent system in migraine patients with phonophobia.","authors":"Emre Soylemez, Aydın Sinan Apaydin, Tugce Gurel Soylemez, Borna Farhoomand, Dursun Ceylan","doi":"10.1080/01616412.2024.2430994","DOIUrl":"10.1080/01616412.2024.2430994","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate Auditory Evoked Brainstem Responses (ABR) and Distortion Product Otoacoustic Emission (DPOAE) suppression in migraine patients with and without phonophobia.</p><p><strong>Methods: </strong>Thirty-two migraine patients with normal hearing and 30 healthy individuals were included in the study. Migraine characteristics and phonophobia status of migraine patients were noted. The patients were divided into two groups according to their phonophobia status. All participants underwent ABR, DPOAE and DPOAE suppression.</p><p><strong>Results: </strong>Migraine patients had less DPOAE suppression (1481 and 2222 hz) and shorter ABR wave latencies compared to the control group (<i>p</i> < 0.05). Twelve (37.5%) of the migraine patients did not have phonophobia, and 20 (62.5%) had phonophobia. Phonophobia was not found to affect DPOAE suppression (<i>p</i> > 0.05). However, ABR wave I and V latencies in migraine patients with phonophobia were shorter than in healthy individuals (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>There are changes in the auditory evoked brainstem responses and medial olivocochlear efferent system of migraine patients. While phonophobia in migraine patients does not affect the medial olivocochlear efferent system, it may affect auditory evoked brainstem responses.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"7-14"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mobile stroke units based on rural emergency medical stations for pre-hospital intravenous thrombolysis of stroke in remote areas. 基于农村急救站的流动卒中单元,用于偏远地区卒中的院前静脉溶栓治疗。
IF 1.7 4区 医学
Neurological Research Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1080/01616412.2024.2423588
Bin Liu, Pengcheng Zhang, Hongyun Wang, Qianqian Miao, Shuaishuai Wang, Wenting Zhang
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