Neurological Research最新文献

{"title":"Association of the PTGS2 8473T>C polymorphism with depression and nausea in Iranian migraineurs.","authors":"Elaheh Mozaffari, Maryam Mehrinejad Khotbehsara, Mostafa Faghani, Shiva Asadi, Saghar Hoseinzadeh, Mohammadreza Allahyartorkaman, Reza Nemati, Houman Salimipour, Ahmad Fazilat","doi":"10.1080/01616412.2025.2504146","DOIUrl":"10.1080/01616412.2025.2504146","url":null,"abstract":"<p><strong>Background: </strong>Migraine is a complex neurological disorder lacking reliable assessment methods. Non-steroidal anti-inflammatory drugs relieve migraine pain by inhibiting prostaglandin synthesis through COX-1 and COX-2 suppression. As COX-2 plays a key role in pain and inflammation, its modulation is vital in migraine therapy. We hypothesized that the COX-2 8473 T>C (rs5275) gene variant may be linked to migraine, depression, and nausea.</p><p><strong>Methods: </strong>In this case-control study, genomic DNA from 100 migraine patients and 100 controls was analyzed for the <i>COX-2 8473 T>C (rs5275)</i> polymorphism using PCR-RFLP.</p><p><strong>Results: </strong>Statistical analysis revealed a significant association between the <i>COX-2 8473 T>C</i> variant and increased risk of migraine progression, depression, and nausea. The T+ genotype was more prevalent in controls than in patients (93% and 68% respectively; <i>p</i> < 0.0001), while the C+ genotype was more frequent in patients than controls (70% and 25% respectively; <i>p </i>< 0.001). Among migraineurs with depression, 75% carried the C+ genotype compared to 25% in controls (<i>p</i> < 0.001). Similarly, 76.1% of migraine patients with nausea had the C+ genotype, versus 25% of controls (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The <i>COX-2 8473 C+</i> genotype appears to increase the risk of migraine, depression, and nausea, while the T+ genotype may have a protective effect. This comparative genomics study highlights the potential role of the <i>COX-2 8473 C+</i> genotype in migraine manifestation, though further research is needed to clarify its pathogenic involvement.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"807-816"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An adaptive frequency partitioning framework for epileptic seizure detection using TransseizNet.","authors":"G R Abijith, S Jothi, Chandrasekar A","doi":"10.1080/01616412.2025.2507323","DOIUrl":"10.1080/01616412.2025.2507323","url":null,"abstract":"<p><strong>Objectives: </strong>Epilepsy is a disorder causing repeated seizures because of unusual brain activity recorded using electroencephalography. Nevertheless, conventional epilepsy seizure detection approaches face difficulties such as poor epilepsy seizure detection accuracy and higher computational complexity. To overcome these limitations, this work proposes a novel TransseizNet framework for epilepsy seizure detection from the electroencephalography signal.</p><p><strong>Methods: </strong>The electroencephalography data from three datasets are pre-processed using the Savitzky-Golay filter. The proposed framework utilizes the Empirical Tunable Q-Wavelet Transform for signal decomposition, which is the combination of the Empirical Wavelet Transform and the Tunable Q-factor Wavelet Transform. This enhances time-frequency resolution and adaptively captures localized oscillatory patterns critical for precise seizure detection. The proposed framework utilizes a Wavelet-Graph Convolutional Network Vision Transformer for epilepsy seizure detection and classification. The integration of wavelet-driven attention with graph-based learning enhances spatial-temporal feature representation, which makes seizure detection more accurate, interpretable, and computationally efficient than the baseline approaches.</p><p><strong>Results: </strong>The TransseizNet model is trained and validated on three datasets and achieves an average accuracy of 98.65% a precision of 98.59%, a F1-score of 98.45%, a recall of 98.30%, a specificity of 98.52%, a computational time of 17 sec, and the detection latency of 2.5 sec, which outperforms the performance of baseline approaches in the detection of epileptic seizures.</p><p><strong>Discussion: </strong>TransseizNet framework provides superior performance in seizure detection by efficiently integrating adaptive frequency decomposition and hybrid deep learning. Its minimal detection latency, higher accuracy, and interpretability make it suitable for practical healthcare uses.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"876-890"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/01616412.2025.2510034","DOIUrl":"10.1080/01616412.2025.2510034","url":null,"abstract":"","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"i"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Autophagy-related Gene NLRC4 in spinal cord injury.","authors":"Qie Gu, Hongbo Fan, Siqi Zhang, Shuaishuai Xia, Xuemei Tan, Xiang Zhou","doi":"10.1080/01616412.2025.2503462","DOIUrl":"10.1080/01616412.2025.2503462","url":null,"abstract":"<p><strong>Background/objectives: </strong>To investigate the role of the autophagy-related gene NLR Family CARD Domain Containing 4 (NLRC4) in spinal cord injury via bioinformatics methods, which may provide new targets for the diagnosis and treatment of spinal cord injury.</p><p><strong>Methods: </strong>This analysis is based on the GEO database dataset GSE151371. To identify potential autophagy-related genes involved in SCI, protein‒protein interaction (PPI) networks were analyzed. Immune microenvironment analysis (LM22) was performed via the CIBERSORTx database to determine the makeup of 22 immune cell types. Furthermore, a rat spinal cord injury model was generated, and the expression of selected autophagy-related genes was validated via immunofluorescence labeling and Western blotting.</p><p><strong>Results: </strong>Disease enrichment analysis via the Metascape database revealed enrichment for diseases related to the spinal cord, inflammation, infection, and immunity, which aligns with the functional analysis results of previously identified genes. Through the PPI and autophagy-related genes, we identified NLRC4 within the key subnetwork of the PPI network, highlighting its significance as a key signature gene associated with SCI. NLRC4 expression was significantly increased in the three groups, which was correlated with the severity of SCI. In the rat SCI model, NLRC4 protein expression was significantly greater in the SCI group than in the sham group (<i>p</i> < 0.001), confirming the validity of the model.</p><p><strong>Conclusions: </strong>Since NLRC4 is an important gene involved in the autophagy that leads to spinal cord damage, it can be utilized to illuminate the optimal approach to immunotherapy for individuals with SCI and uncover new targets for therapy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"791-806"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of temporomandibular disorder comorbidity on pain, quality of life, sleep, and functional outcomes in chronic migraine patients not using preventive treatment: a cross-sectional study.","authors":"Alper Mengi, Ugur Uygunoglu","doi":"10.1080/01616412.2025.2507755","DOIUrl":"10.1080/01616412.2025.2507755","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate pain, quality of life, sleep, and functional outcomes between chronic migraine (CM) patients with temporomandibular disorder (TMD) and patients with CM alone.</p><p><strong>Methods: </strong>Thirty one patients with CM and thirty one patients with CM+TMD were recruited in the study. All patients had not been on preventive treatment for CM or TMD in the previous three months. TMD was examined by physical examination, guided by the subdomains of the Helkimo Clinical Dysfunction Index (HCDI). All patients were evaluated for allodynia using the Allodynia Symptom Checklist (ASC-12), quality of life using the 36-item Short Form Health Survey (SF-36), headache-related disability using the Migraine Disability Assessment Scale (MIDAS) and the Headache Impact Test (HIT-6), and sleep quality using the Pittsburgh Sleep Quality Index (PSQI).</p><p><strong>Results: </strong>The average pain intensity was higher in patients with CM+TMD (<i>p</i> < 0.001). The number of patients with a migraine attack duration of more than 3 days were significantly higher in the same group (<i>p</i> = 0.001). ASC-12 scores were significantly elevated in patients with CM+TMD (<i>p</i> < 0.001). MIDAS and HIT-6 scores were significantly higher in the CM+TMD patient group (<i>p</i> = 0.010, <i>p</i> < 0.001, respectively). HCDI score was significantly positively correlated with age, BMI, average number of headache days in a month, ASC-12 score, PSQI sleep disturbance domain score, and PSQI total score (<i>r</i> = 0.625, 0.406, 0.417, 0.484, 0.499, and 0.487, respectively).</p><p><strong>Conclusion: </strong>In patients with CM, TMD comorbidity significantly associated with high average pain intensity, migraine attack duration, and allodynia. Physicians managing headaches should not overlook TMD symptoms in CM and should benefit from collaborating with TMD specialists to address TMD symptoms effectively.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"891-899"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance and biological function of miR-3613-3p in glioma.","authors":"Yang Zhang, Peng Zhou, Hanchang Yu","doi":"10.1080/01616412.2025.2551870","DOIUrl":"https://doi.org/10.1080/01616412.2025.2551870","url":null,"abstract":"<p><strong>Objectives: </strong>Gliomas are a prevalent form of brain tumor with broad invasion, which has a worse prognosis and the survival rate. This study aims to investigate the clinical significance of miR-3613-3p in glioma patients.</p><p><strong>Methods: </strong>We collected blood samples from 84 glioma patients and 84 healthy controls for further analysis. The expression levels of miR-3613-3p were evaluated using RT-qPCR. Kaplan-Meier methods were used to assess overall survival, and we used multivariate Cox proportional hazards regression analysis to assess the prognostic factors. Apoptosis was evaluated through flow cytometry and the MTT assay measured the proliferation. The results of the dual-luciferase reporter assay were evidence for the relationship between miR-3613-3p and EphA7.</p><p><strong>Results: </strong>Kaplan-Meier analysis indicated that patients with low expression levels of miR-3613-3p exhibited a poorer prognosis compared to those with high expression levels. Multivariate Cox proportional hazards regression analysis confirmed that miR-3613-3p expression was associated with glioma patient prognosis. MiR-3613-3p inhibited proliferation and promoted apoptosis in glioma cells. MiR-3613-3p negatively regulated EphA7 expression levels, and overexpressing miR-3613-3p reversed the reduction of the apoptosis rate and increase of cell proliferation caused by overexpression of EphA7.</p><p><strong>Conclusion: </strong>In this research, we identified that high expression levels of miR-3613-3p were associated with a better prognosis and EphA7 was negatively regulated by miR-3613-3p to inhibit the development of glioma.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into modifiable risk factors of migraine: a Mendelian randomization analysis.","authors":"Junyi Yang, Yuanjie Duan, Qian Wu, Yumei Ma, Shutong Tan, Yue Zhang, Jian Zhang, Xu Liu","doi":"10.1080/01616412.2025.2504717","DOIUrl":"10.1080/01616412.2025.2504717","url":null,"abstract":"<p><strong>Objectives: </strong>Increasing epidemiological evidence has reported that various factors are associated with migraine risk and subtypes. Nevertheless, definitive conclusions regarding whether the putative modifiable risk factors are causally related to the pathogenesis of migraine have not been drawn.</p><p><strong>Methods: </strong>Using single-nucleotide polymorphisms as instrumental variables, we conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal effects of 38 modifiable factors, including dietary nutrients, lifestyle factors, cardiometabolic diseases, and associated traits, as well as reproductive characteristics and sex hormones, on the risk of migraine, migraine with aura (MA), and migraine without aura (MO). Subsequently, meta-analyses were performed to combine causal estimates from two independent genome-wide association studies.</p><p><strong>Results: </strong>In the combined findings with multiple test correction, genetically predicted higher alcohol intake frequency (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.12-1.40), lifetime smoking index (OR: 1.24; 95% CI: 1.08-1.42), insomnia (OR: 1.20; 95% CI: 1.17-1.24), long sleep duration (OR: 1.26; 95% CI: 1.07-1.50), and hypertension (OR: 1.76; 95% CI: 1.47-2.11) were causally linked to migraine incidence. Subgroup analyses revealed higher carbohydrate and sugar intake, alcohol consumption frequency, lifetime smoking index, insomnia, and hypertension causally increased susceptibility to MA, while later age at first birth (AFB) had a protective effect on MA risk. Meanwhile, the MR findings revealed a detrimental association between alcohol intake frequency, insomnia, hypertension, and early AFB and MO incidence.</p><p><strong>Discussion: </strong>Overall, our study demonstrated various causal risk factors for migraine and its subtypes risk, providing insights into its pathogenesis and potential prevention strategies. Further research is needed to validate these findings and explore their clinical implications and underlying mechanisms.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"844-863"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effect of Bergenin in diabetic neuropathy: modulation of AMPK and NF-κB signaling.","authors":"Ahmed I Foudah, Mohammed H Alqarni, Mohamed F Balaha, Sushma Devi, Aftab Alam","doi":"10.1080/01616412.2025.2504716","DOIUrl":"10.1080/01616412.2025.2504716","url":null,"abstract":"<p><strong>Aim and objectives: </strong>This study explores the therapeutic potential of Bergenin (BER), a plant-derived bioactive compound, in treating diabetic neuropathy, with a focus on its effects on activated protein kinase (AMPK) signaling pathways.</p><p><strong>Methodology: </strong>Diabetic rats were randomly divided into several groups: a control group, an STZ-only group, control groups treated with varying doses of BER (10, 20, and 40 mg/kg), and a group treated with pregabalin (PRE) at 10 mg/kg. After the treatment period, blood samples and sciatic nerve tissues were collected for analysis.</p><p><strong>Results: </strong>The results showed that BER, particularly at the highest dose, produced a sustained reduction in blood glucose levels, indicating a potential dose-dependent effect. BER also significantly alleviated cold allodynia, mechanical allodynia, and mechanical hyperalgesia, supporting its promise as a pain management option for diabetic neuropathy. Treatment with 40 mg/kg BER notably reduced oxidative stress markers and boosted antioxidant levels. Additionally, BER inhibited NF-kβ activity, reduced neuroinflammation, and suppressed the production of inflammatory cytokines such as TNF-α and NF-kβ. Activation of AMPK, confirmed by elevated P-AMPK levels, suggests that BER may help restore damaged cellular pathways associated with diabetic neuropathy.</p><p><strong>Conclusion: </strong>In conclusion, BER demonstrates strong potential as a therapeutic agent, reducing inflammation and oxidative stress while enhancing nerve function, likely through modulation of AMPK signaling pathways.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"826-843"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the cortical processing of pain in patients with migraine using middle latency somatosensory evoked potentials: a case-control study.","authors":"Alaa M Essam, Manar Mossad, Mona Hussein, Zeinab Mohammed, Rehab Elanwar","doi":"10.1080/01616412.2025.2502783","DOIUrl":"10.1080/01616412.2025.2502783","url":null,"abstract":"<p><strong>Objectives: </strong>Strong evidence suggested the presence of abnormal cortical processing of pain in patients with migraine during and in between the attacks. The aim of this work was to assess the possible alterations in cortical excitability in patients with migraine in between the attacks using middle latency somatosensory evoked potential. The second objective was to study the relationship between cortical excitability in patients with migraine, and severity, frequency, and duration of migraine headache attacks.</p><p><strong>Methods: </strong>This case-control study was conducted on 40 migraine patients and 40 age and sex matched healthy controls. Severity of migraine was assessed using Migraine Severity Scale (MIGSEV), Headache Impact Test-6 (HIT-6), and Visual Analogue Scale (VAS). The peak latencies and amplitudes of the middle latency somatosensory evoked potentials (SSEPs) were measured for patients and controls.</p><p><strong>Result: </strong>There was a statistically significant difference between Migraine patients and controls regarding middle latency SSEPs variables. There was no statistically significant correlation between middle latency SSEPs variables in patients with migraine and either age, body mass index (BMI), disease duration, monthly migraine days, duration of migraine headache attacks, MIGSEV, HIT-6, or VAS.</p><p><strong>Discussion: </strong>Patients with migraine have a significantly higher cortical excitability in comparison to controls. No significant relationship between cortical excitability in patients with migraine and either severity, frequency, or duration of migraine headache attacks.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"761-772"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of oral supplementation of vitamin B12 and plasma levels of homocysteine on progression and survival in a Chinese ALS cohort.","authors":"Nan Hu, Jianfeng Ding, Huihong Tian, Dongchao Shen, Xunzhe Yang, Jingwen Niu, Mingsheng Liu, Liying Cui","doi":"10.1080/01616412.2025.2553147","DOIUrl":"https://doi.org/10.1080/01616412.2025.2553147","url":null,"abstract":"<p><strong>Objective: </strong>We investigate the impact of plasma levels of folate, vitamin B12 (VB12), homocysteine (HCY) and oral supplementation of folate and VB12 on amyotrophic lateral sclerosis (ALS) progression and survival.</p><p><strong>Methods: </strong>Patients with sporadic ALS were consecutively enrolled and regularly followed up. Oral supplementation of folate and VB12 was recommended to all involved patients. Tests of plasma levels of folate, VB12 and HCY were conducted before or after medication.</p><p><strong>Results: </strong>A total of 120 sporadic ALS patients with results of plasma folate, VB12 or HCY were finally included. Oral supplementation of VB12 significantly increased the plasma levels of folate (<i>p</i> < 0.01) and VB12 (<i>p</i> < 0.01), and lower HCY (<i>p</i> < 0.001). The progression rate of ALS patients in the first 3-6 months was negatively related to the plasma level of VB12 (<i>p</i> = 0.008). After taking VB supplements, the progression rate in the first 3-6 months was comparable to previous progression rate (<i>p</i> = 0.102) and significantly lower than that in the 9-12 month follow-up (<i>p</i> < 0.01). There was no significant difference in survival time between the two groups that took VB12 and those who did not take it neither between patients with high and low serum levels of folate, VB12 or HCY.</p><p><strong>Conclusion: </strong>Oral intake of VB12 supplements may significantly increase plasma levels of folate and VB12 and decrease plasma levels of HCY in ALS patients. Oral supplementation of folate and VB12, and subsequent high levels of VB12 in serum, may lower the ALS progression at the early stages but show no significant impact on ALS survival time.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}