Electroacupuncture combined with botulinum toxin type A promotes common peroneal nerve repair and activation of GDNF-BDNF/TrkB signaling pathway in post-stroke limb spasticity rats.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-08-28 DOI:10.1080/01616412.2025.2553149

Jinyu Qu, Jin Xiong, Weiwei Zhang, Xiaoying Cao, Juanli Jiang, Xiaodan Xu, Huan Wang, Yingchun Peng, Xuefang Shen, Changlong Luan, Lan Wen, Yili Wang

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引用次数: 0

Abstract

Background: Post-stroke limb spasticity (PSLS) is a rehabilitation problem that needs to be solved urgently, electroacupuncture (EA), a safe and effective adjunctive rehabilitation therapy with relatively few side effects, and botulinum toxin type A (BTX-A) can improve motor function; however, it is not clear whether EA combined with BTX-A is more effective in improving PSLS. This study will investigate the effects and mechanisms of EA combined with BTX-A to improve PSLS in rats.

Methods: PSLS rat model was prepared and treated with EA, BTX-A, or EA+BTX-A, Zea longa, modified Ashworth, and modified neurological severity score to assess the changes of neurological function and dystonia, and to observe the cerebral infarction condition, fibers changes of gastrocnemius muscle, common peroneal nerve pathology morphology, changes of neural repair factors and GDNF/BDNF/TrkB signaling pathway in the rats, respectively.

Results: The results showed that EA combined with BTX-A effectively promotes the recovery of neurological function in rats with post-stroke limb spasticity, improves axonal and myelin regeneration of the gastrocnemius nerve on the operated side, promotes the repair of the common peroneal nerve, and activates the GDNF-BDNF/TrkB signaling pathway.

Conclusions: Collectively, EA combined with BTX-A for the treatment of PSLS may be associated with the promotion of common peroneal nerve repair and modulation of the GDNF-BDNF/TrkB signaling pathway.

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电针联合A型肉毒杆菌毒素促进脑卒中后肢体痉挛大鼠腓总神经修复和GDNF-BDNF/TrkB信号通路的激活

背景：脑卒中后肢体痉挛（PSLS）是一个亟待解决的康复问题，电针（EA）是一种安全有效、副作用相对较少的辅助康复疗法，a型肉毒毒素（BTX-A）可改善运动功能；然而，尚不清楚EA联合BTX-A是否更有效地改善PSLS。本研究将探讨EA联合BTX-A对大鼠PSLS的改善作用及其机制。方法：制备PSLS大鼠模型，分别用EA、BTX-A、或EA+BTX-A、Zea longa、改良Ashworth、改良神经严重度评分法评价大鼠神经功能和张力障碍的变化，观察大鼠脑梗死情况、腓肠肌纤维变化、腓总神经病理形态、神经修复因子和GDNF/BDNF/TrkB信号通路的变化。结果：结果显示，EA联合BTX-A能有效促进脑卒中后肢体痉挛大鼠神经功能恢复，促进手术侧腓骨神经轴突和髓鞘再生，促进腓总神经修复，激活GDNF-BDNF/TrkB信号通路。结论：总的来说，EA联合BTX-A治疗PSLS可能与促进腓总神经修复和调节GDNF-BDNF/TrkB信号通路有关。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.