脑脊液儿茶酚胺水平与阿尔茨海默病、炎症和神经元损伤生物标志物的关系

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-08-03 DOI:10.1080/01616412.2025.2542944

Isabel Portela Moreira, Paula Serrão, Lucinda Sequeira, Maria José Sá, Maria Augusta Vieira-Coelho, Joana Guimarães

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引用次数: 0

摘要

目的：蓝斑的改变是阿尔茨海默病（AD）的早期事件之一。我们旨在评估脑脊液（CSF） l -二羟基苯丙氨酸（L-DOPA）、多巴胺和去甲肾上腺素与阿尔茨海默病脑脊液生物标志物（β-淀粉样蛋白和p-tau）、神经元破坏（神经丝）和炎症（白细胞、IgG指数、白细胞介素-6和10）之间的关系。方法：我们进行了一项横断面观察性研究，包括35例AD患者，16例额颞叶痴呆患者和38例正常对照（NC）。结果：AD组左旋多巴含量低于NC组（p = 0.032），神经纤维含量高于NC组（p = 0.005）。去甲肾上腺素水平与年龄呈正相关（r = 0.260, p = 0.015）。左旋多巴水平与神经丝呈负相关（r = -0.228, p = 0.038）。白细胞介素-6与AD患者L-DOPA （r = 0.382, p = 0.026）、去甲肾上腺素（r = 0.485, p = 0.004）水平呈正相关。结论：神经丝与神经元损伤有关，AD患者左旋多巴水平降低可能与神经元损伤有关。在AD中看到的儿茶酚胺能失调似乎与β-淀粉样蛋白和p-tau病理无关。

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Relationship between cerebrospinal fluid catecholamines levels and biomarkers of Alzheimer's disease, inflammation and neuronal injury.

Objectives: Changes in the locus coeruleus are among the earliest events in Alzheimer's disease (AD). We aimed to evaluate the relationship between cerebrospinal fluid (CSF) L-dihydroxyphenylalanine (L-DOPA), dopamine, and norepinephrine with CSF biomarkers of AD pathology (β-amyloid and p-tau), neuronal destruction (neurofilaments), and inflammation (leukocytes, IgG index, interleukin-6 and 10).

Methods: We conducted a cross-sectional, observational study, including 35 patients with AD, 16 with frontotemporal dementia, and 38 normal controls (NC).

Results: L-DOPA was lower (p = 0.032) and neurofilaments were higher (p = 0.005) in AD than in NC. Norepinephrine levels were positively correlated with age (r = 0.260, p = 0.015 among all patients). L-DOPA levels were negatively correlated with neurofilaments (r = -0.228, p = 0.038 among all participants). Interleukin-6 was positively correlated with L-DOPA (r = 0.382, p = 0.026) and norepinephrine (r = 0.485, p = 0.004) levels in AD.

Conclusion: Since neurofilaments are associated with neuronal damage, decreased L-DOPA levels in AD could be related to neuronal destruction. Catecholaminergic dysregulation seen in AD seems independent of β-amyloid and p-tau pathology.

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.