Prevalence of wake-up stroke: a systematic review and meta-analysis.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-07-28 DOI:10.1080/01616412.2025.2534517

Yuting Zhao, Jia Li, Ying Zhu, Qiuxia Qian, Xiaoling Qian, Longchun Hua, Jianxun Cao, Yuxia Ma

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引用次数: 0

Abstract

Background: Wake-up stroke (WUS) is a subgroup of ischemic stroke in which patients show no abnormality before sleep, while wake up with neurological deficits, and the prevalence varied widely across studies. To obtain a true estimate of WUS, we conducted a systematic review and meta-analysis of previously published data.

Methods: PubMed, the Cochrane Library, Web of Science, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure Database (CNKI), Wanfang Database and Weipu Database (VIP) were searched from their inception through 1 April 2025 to identify population-based, observational studies that reported the prevalence of WUS.

Results: The meta-analysis included 37 studies involving 196,744 individuals. The pooled prevalence of WUS was 23.1% (95% CI: 21.1%-25.1%, I² = 98.8%). The results of the subgroup analysis showed that the pooled prevalence of WUS was 22.8% (95% CI: 21%-25%) in women and 24% (95% CI: 22%-26%) in men. The pooled prevalence of WUS based on the cross-sectional studies and cohort studies, respectively, was 25.1% (95% CI: 23%-27%) and 17.4% (95% CI: 15%-20%). Based on the regional analysis, the prevalence of WUS was 25% (95% CI: 23%-27%) in Asia, 18.5% (95% CI: 14%-22%) in Europe, and 24.1% (95% CI: 18%-31%) in North America.

Conclusions: The prevalence of WUS is 23.1%, with higher rates observed in men and the Asian region. Increased awareness and training among healthcare professionals are essential for early recognition, potentially improving diagnosis and management in emergency settings. Promoting education on WUS is also vital for reducing associated morbidity and mortality.

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醒脑卒中的患病率：系统回顾和荟萃分析。

背景：觉醒卒中（WUS）是缺血性卒中的一个亚组，患者在睡眠前无异常，而醒来时伴有神经功能障碍，在不同的研究中患病率差异很大。为了获得WUS的真实估计，我们对先前发表的数据进行了系统回顾和荟萃分析。方法：检索PubMed、Cochrane图书馆、Web of Science、Embase、中国生物医学文献数据库（CBM）、中国国家知识基础数据库（CNKI）、万方数据库和卫普数据库（VIP），从建库到2025年4月1日，确定报告WUS患病率的基于人群的观察性研究。结果：荟萃分析包括37项研究，涉及196,744人。WUS的总患病率为23.1% （95% CI: 21.1% ~ 25.1%, I2 = 98.8%）。亚组分析结果显示，女性WUS的总患病率为22.8% (95% CI: 21%-25%)，男性为24% （95% CI: 22%-26%）。基于横断面研究和队列研究的WUS合并患病率分别为25.1% （95% CI: 23%-27%）和17.4% （95% CI: 15%-20%）。根据区域分析，WUS患病率在亚洲为25% (95% CI: 23%-27%)，在欧洲为18.5% (95% CI: 14%-22%)，在北美为24.1% （95% CI: 18%-31%）。结论：WUS的患病率为23.1%，男性和亚洲地区的患病率更高。提高保健专业人员的认识和培训对于早期识别至关重要，这可能会改善紧急情况下的诊断和管理。促进WUS教育对于降低相关发病率和死亡率也至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.