Low mean platelet volume: a risk factor for increased intraoperative blood loss in degenerative lumbar surgery.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-07-31 DOI:10.1080/01616412.2025.2541292

Ehsan Alimohammadi, Alireza Sadeghsalehi, Fatemeh Ranjbari, Seifollah Ghahari Ahangar, Seyed Reza Bagheri

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引用次数: 0

Abstract

Background: Major intraoperative blood loss (MIBL) is associated with increased morbidity and poorer outcomes. This study investigates whether preoperative mean platelet volume (MPV) may serve as a predictive biomarker for MIBL in patients undergoing degenerative lumbar surgery.

Methods: A retrospective review of 421 patients with lumbar degenerative disease who underwent surgery from July 2019 to July 2022 was conducted. MIBL was defined as blood loss > 1000 ml. Patients were divided into MIBL and non-MIBL groups. Potential risk factors, including MPV, were compared. The optimal MPV cutoff (10.1) was determined using ROC analysis and Youden's index. Patients were grouped into high MPV (≥10.1 fL)and low MPV ( < 10.1 fL). Logistic regression identified independent risk factors for MIBL.

Results: The cohort included 192 males (45.6%) and 229 females (54.4%), with a mean age of 61.4 ± 8.6 years. MIBL occurred in 73 patients (17.3%). The MPV distribution was 37.8% ( < 10.1 fL) and 62.2% (≥10.1 fL). Logistic regression revealed that higher mean arterial pressure (OR 3.11, 95% CI 1.72-5.21, p < 0.001), greater number of fused levels (OR 2.73, 95% CI 1.72-4.53, p = 0.016), longer surgical duration (OR 1.89, 95% CI 1.43-2.89, p = 0.021), and lower MPV (OR 1.72, 95% CI 1.17-2.26, p = 0.027)were independently associated with MIBL.

Conclusions: Lower MPV may indicate an increased risk of intraoperative blood loss in lumbar degenerative surgery. Monitoring MPV - a simple, cost-effective biomarker - may assist in optimizing fluid management and blood conservation strategies. However, given the retrospective nature of this study, these findings should be interpreted with caution.

查看原文本刊更多论文

低平均血小板体积：退行性腰椎手术中术中出血量增加的危险因素。

背景：术中大量失血（MIBL）与发病率增加和预后较差相关。本研究探讨了术前平均血小板体积（MPV）是否可以作为退行性腰椎手术患者MIBL的预测性生物标志物。方法：对2019年7月至2022年7月行腰椎退行性疾病手术治疗的421例患者进行回顾性分析。MIBL定义为失血量> 1000ml。将患者分为MIBL组和非MIBL组。比较包括MPV在内的潜在危险因素。采用ROC分析和约登指数确定最佳MPV截止值（10.1）。结果：男性192例（45.6%），女性229例（54.4%），平均年龄61.4±8.6岁。73例（17.3%）发生MIBL。MPV分布为37.8% (p = 0.016)，较长的手术时间（OR 1.89, 95% CI 1.43-2.89, p = 0.021）和较低的MPV （OR 1.72, 95% CI 1.17-2.26, p = 0.027）与MIBL独立相关。结论：较低的MPV可能表明腰椎退行性手术中术中失血风险增加。监测MPV是一种简单、经济的生物标志物，可以帮助优化流体管理和血液保护策略。然而，考虑到本研究的回顾性，这些发现应谨慎解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.