Neurological Research最新文献

{"title":"Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population.","authors":"Afef Achouri-Rassas, Saloua Fray, Zakaria Said, Samia Ben Sassi, Nadia Ben Ali, Ghada Baraket","doi":"10.1080/01616412.2025.2472841","DOIUrl":"10.1080/01616412.2025.2472841","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is the leading cause of major neurodegenerative cognitive impairment. The risk of developing AD is influenced by a complex interaction of genetic predisposition and environmental factors. Among the genetic risk factors, the APOE ɛ4 allele is the most significant, while variants in the TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) and ABCA7 (ATP-binding cassette transporter A7) genes have also been associated with an increased risk of AD.</p><p><strong>Objective: </strong>This study aimed to investigate the association of APOE ɛ4, TREM2 gene variants (rs75932628 [p.R47H] and rs2234253 [p.T96K]), and ABCA7 gene variants (rs142076058 and rs115550680) with sporadic AD in the Tunisian population. Methods: A case-control study was conducted including 222 Tunisian patients diagnosed with sporadic AD and 99 cognitively healthy controls. Genotyping was performed to assess the presence and association of the selected genetic variants with AD. Statistical analyses were conducted to determine the significance of genetic associations.</p><p><strong>Results: </strong>A significant association was found between the TREM2 rs2234253 (p.T96K) variant and AD, with the T allele identified as a risk factor in the Tunisian population. The APOE ɛ4 allele was also associated with an increased risk of developing AD. However, no significant association was observed for the ABCA7 gene variants or the TREM2 rs75932628 (p.R47H) variant in either the AD or control groups.</p><p><strong>Conclusion: </strong>Our findings suggest that the TREM2 rs2234253 (p.T96K) variant is a significant genetic risk factor for late-onset AD (LOAD) in the Tunisian population. Further studies with larger cohorts are needed to validate these findings and explore potential gene-gene interactions contributing to AD risk.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"290-295"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an <i>in vitro</i> study.","authors":"Haizhen Jia, Huajun Fan, Jiarui Liang, Runqing He","doi":"10.1080/01616412.2025.2470714","DOIUrl":"10.1080/01616412.2025.2470714","url":null,"abstract":"<p><strong>Objective: </strong>Ferroptosis, a regulated cell death pathway driven by lipid peroxidation and iron overload, is implicated in neuronal injury caused by hypoxia/reoxygenation (H/R). Caffeine, a widely consumed psychoactive compound, has shown neuroprotective effects in various central nervous system disorders, but its role in regulating ferroptosis remains unclear. This study investigates the neuroprotective effects of caffeine on ferroptosis and its regulation of ACSL4, a key ferroptosis-related protein.</p><p><strong>Methods: </strong>Molecular docking was performed to evaluate the interaction between caffeine and ferroptosis-related proteins ACSL4 and GPX4. HT-22 cells were subjected to H/R to establish an <i>in vitro</i> injury model, followed by treatment with caffeine at varying concentrations. ACSL4 was silenced or overexpressed to explore its role in caffeine-mediated ferroptosis regulation. Cell viability, inflammatory cytokines, ferroptosis markers, and mitochondrial function were assessed.</p><p><strong>Results: </strong>Molecular docking revealed favorable binding affinities of caffeine with ACSL4 (-5.6 kcal/mol) and GPX4 (-4.6 kcal/mol). Caffeine treatment dose-dependently improved cell viability, reduced TNF-α, IL-1β, and IL-6 levels, and inhibited ferroptosis by downregulating ACSL4 and upregulating GPX4. Overexpression of ACSL4 reversed these protective effects, increasing lipid peroxidation markers (iron, Fe2+, ROS, and MDA) and reducing GSH levels and mitochondrial membrane potential. Conversely, silencing ACSL4 enhanced caffeine's protective effects, confirming its role as a critical target of caffeine-mediated ferroptosis inhibition.</p><p><strong>Conclusion: </strong>Caffeine protects against H/R-induced neuronal injury by regulating ACSL4-mediated ferroptosis, reducing oxidative stress and inflammation. These findings highlight ACSL4 as a therapeutic target and provide mechanistic insights into caffeine's neuroprotective potential.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"242-250"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the efficacy and safety of combined arterial and venous thrombolysis in the treatment of acute ischemic stroke.","authors":"Wenjun Liu, Guohui Ye, Shiqi Xie, Hai Hu","doi":"10.1080/01616412.2025.2482766","DOIUrl":"https://doi.org/10.1080/01616412.2025.2482766","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the efficacy and safety of combined arterial and venous thrombolysis in the treatment of acute ischemic stroke.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) were systematically evaluated by comprehensive literature review and inclusion criteria. Cochrane bias risk assessment tool was used to evaluate the research quality, and RevMan 5.3 software was used for Meta-analysis. The main outcome indicators included NIHSS, MRS, recanalization rate, cerebral hemorrhage and mortality.</p><p><strong>Results: </strong>20 articles were finally included, including 2287 subjects, including 1096 cases in the combined group and 1191 cases in the control group, all of which were randomized controlled experiments. The improvement of NIHSS score in combined thrombolysis group was better than that in control group (OR = 1.79, <i>p</i> < 0.001). The improvement of mRS score in the combined thrombolysis group was better than that in the control group (OR = 1.54, <i>p</i> < 0.01). The recanalization rate of artery and vein combined with thrombolysis was better (OR = 2.91, <i>p</i> < 0.01). There was no significant difference in the risk of symptomatic cerebral hemorrhage after thrombolysis between the two groups (<i>p</i> > 0.05). The combined thrombolysis group had a better risk of death after thrombolysis (OR = 0.53, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Arteriovenous thrombolysis combined with acute cerebral infarction has advantages in NIHSS, MRS and recanalization rate. However, there was no significant increase in arterial or intravenous thrombolysis for symptomatic cerebral hemorrhage. Arteriovenous combined thrombolysis may have curative effect and acceptable safety in acute ischemic stroke.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can lactate levels predict progression to status epilepticus in generalized convulsive epileptic seizures?","authors":"İhsan Dengiz, Selen Acehan, Salim Satar, Muge Gulen, Sarper Sevdimbas, Mert Pehlivan, Melike Kucukceylan, Mehmet Gorur, Ali İsa Aslan, Figen Topalak","doi":"10.1080/01616412.2025.2472829","DOIUrl":"10.1080/01616412.2025.2472829","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to analyze the factors predicting the progression to status epilepticus (SE) in patients who presented with generalized convulsive epileptic (GCE) seizures.</p><p><strong>Materials and methods: </strong>Patients included in the study were grouped as SE (+) and (-) patients. In addition to hemogram, biochemistry and blood gas parameters, the levels of antiepileptic drugs used by the patients at the time of presentation to the emergency department (ED) were also studied. Blood gas parameters at the 2nd hour of follow-up were retaken and lactate clearance was calculated and recorded on the data form.</p><p><strong>Results: </strong>26.7% of the patients were SE (+). A statistically significant, moderate correlation was observed between postictal time and both lactate₀(<i>r</i> = 0.663; <i>p</i> < 0.001) and lactate₂levels (<i>r</i> = 0.626; <i>p</i> < 0.001). In the analyses performed for the association with the presence of SE, presence of seizures within the last week (OR: 17.15, 95% CI: 1.322-222.505, <i>p</i> = 0.030), lactate₂(OR: 2.055, 95% CI: 1.367-3.090, <i>p</i> = 0.001), lactate₀(OR: 1.520, 95% CI: 1.030-1.283, <i>p</i> = 0.006), pulse rate (OR: 1.150, 95% CI: 1.150, 95% CI: 11.012-3.054, <i>p</i> = 0. 045) and leukocyte (OR: 0.469, 95% CI: 0.254-0.868, <i>p</i> = 0.016) values were independent predictors of the presence of SE. In the ROC analysis, it was determined that lactate₀value had the highest predictive power (AUC: 0.908, 95% GA 0.860-0.955, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>According to the study data, the presence of a significant increase in lactate levels at emergency department presentation should alert the clinician to status epilepticus.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"267-276"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of memantine and donepezil on social memory, anxiety-like behavior and the expression levels of microRNA-124, microRNA-125b, and microRNA-132 in scopolamine-induced memory impairment in rats.","authors":"Pouria Bahmani Kolour, Hamed Ghazvini, Mobin Naderi, Hossein Ghalehnoei, Masoumeh Rezaei Talarposhti","doi":"10.1080/01616412.2025.2472848","DOIUrl":"10.1080/01616412.2025.2472848","url":null,"abstract":"<p><strong>Introduction: </strong>Almost all physiological processes are modulated by microRNAs, therefore, dysregulation of these small regulatory RNAs is observed in a variety of diseases, including cognitive impairments.</p><p><strong>Methods: </strong>In this study, 40 male Wistar rats were randomly divided into five groups of control, scopolamine, donepezil, memantine, and combined administration of donepezil + memantine. Rats in scopolamine, donepezil, memantine, and combined administration of donepezil + memantine groups received scopolamine (1 mg/kg-intraperitoneal) for 7 days. After the last administration of scopolamine, was started injecting donepezil (3 mg/kg-i.p.), memantine (10 mg/kg-i.p.), and combined administration of Donepezil + Memantine (0.5 mg/kg and 5 mg/kg-i.p., respectively), up to 21 days. Twenty-four hours after the last injection, elevated plus-maze, social interaction, open field tests, and gene expression analysis of miR-124, miR-125b, and miR-132 in the hippocampus were carried out.</p><p><strong>Results: </strong>The results of the behavioral tests indicate that donepezil and memantine significantly prevented Scopolamine-induced anxiety, sociability, and social memory decline. The gene expression of selected microRNAs did not significantly differ between the groups.</p><p><strong>Discussion: </strong>This study revealed that donepezil and memantine effectively prevent synaptic plasticity disruption and cognitive decline induced by scopolamine. Findings indicated that this treatment is unrelated to the expression of the selected microRNAs. The positive effects of memantine and donepezil depend on age, dosages, cognitive task demands, and possibly the length and timing of the treatment.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"306-317"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of serum oxidative stress parameters in migraine patients.","authors":"Gözde Ülfer, Burcu Polat, Ahmet Yabalak, Çağrı Çakıcı","doi":"10.1080/01616412.2025.2483873","DOIUrl":"https://doi.org/10.1080/01616412.2025.2483873","url":null,"abstract":"<p><strong>Objectives: </strong>This study was conducted to evaluate the correlation between serum oxidative stress parameters and clinical characteristics of patients with migraine by measuring total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia- modified albumin (IMA), and thiol/disulfide homeostasis levels.</p><p><strong>Materials and methods: </strong>The study included a total of 152 individuals, of whom 76 were diagnosed with migraine and 76 were controls. Disease duration, attack duration, attack frequency, Visual Analog Scale scores, comorbidities, were recorded in the migraine group. Using the serum samples of the patient and control groups, oxidative stress parameters were analyzed by colorimetric methods and evaluated together with clinical findings.</p><p><strong>Results: </strong>In the patient group, the measured total thiol, native thiol, IMA, TOS, and OSI levels were statistically significantly higher than those in the control group (for each group; <i>p</i> < 0.01). The mean TAS level of the patient group was significantly lower than that of the control group (<i>p</i> < 0.01). A significant positive correlation was found between the frequency of attacks and the measured IMA levels (r: 0.244; <i>p</i> = 0.034; <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>This study found that TAS levels decreased, while TOS, OSI, and IMA levels increased during the interictal period in patients with migraine. These parameters shifting toward an oxidant balance may indicate that oxidative stress also plays a role in the pathogenesis of migraine. In addition, the significant positive correlation between the frequency of attacks and IMA levels are likely to indicate that secondary ischemic mechanisms may play a role in the pathophysiology of this condition.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static postural balance and manual dexterity are sex-dependent among a sample of relapsing-remitting multiple sclerosis patients.","authors":"Sonda Jallouli, Sameh Ghroubi, Imen Ben Dhia, Salma Sakka, Mariem Damak, Bedreddine Jaafar, Abdelmoneem Yahia, Mohamed Habib Elleuch, Chokri Mhiri, Omar Hammouda","doi":"10.1080/01616412.2025.2484426","DOIUrl":"https://doi.org/10.1080/01616412.2025.2484426","url":null,"abstract":"<p><strong>Background: </strong>Sex differences in physical, psycho-cognitive and sleep disorders, neuropathic pain and perceived fatigue related to multiple sclerosis (MS) have been studied, but contradictory findings were found. MS studies regarding difference between men and women in postural balance are very scarce and based on subjective assessments. We aimed to investigate the sex difference effects on postural balance and other physical measures among a sample of MS patients.</p><p><strong>Methods: </strong>Data from 8 men and 12 women with MS were compared. The assessed parameters were: static and dynamic postural balance (force platform), manual dexterity (Nine Hole Peg Test (NHPT)), leg muscle strength (Five-Repetition Sit-To-Stand Test), functional mobility (Timed up and Go Test), walking speed (Timed 25-Foot Walk Test), fall risk (Four Square Step Test), cognitive functions (Montreal cognitive assessment (MOCA) and React software), neuropathic pain (Neuropathic Pain Questionnaire 4 (DN4)), perceived fatigue (Hooper index), mood (Hospital Anxiety and Depression Scale), and sleep quality (Spiegel's questionnaire).</p><p><strong>Results: </strong>The center of pressure mean velocity was higher in women than in men in the static condition with eyes closed (<i>p</i> = 0.041, Hedges'g (g) = 0.71). Women showed lower MoCA scores (<i>p</i> = 0.028, g = 1.06) as well as higher NHPT duration (<i>p</i> = 0.002, g = 1.64) (in the dominant hand) and DN4 scores (<i>p</i> = 0.003, g = 1.59) than men. No significant sex differences were found for the remaining parameters.</p><p><strong>Conclusion: </strong>Based on this study among a sample of MS patients, women showed poorer static postural balance and manual dexterity than men probably due to their higher neuropathic pain and cognitive decline. These sex differences should be considered when organizing therapeutic training programs for this population.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-COVID from the perspective of neurologists at the outpatient clinic: A cross-sectional field study.","authors":"Artemios Artemiadis, Andreas G Tofarides, Andreas Liampas, Christiana Ioannou, Katerina Christodoulou, Rafaela Louka, George Vavougios, Panagiotis Zis, Panagiotis Bargiotas, Georgios Hadjigeorgiou","doi":"10.1080/01616412.2025.2472824","DOIUrl":"10.1080/01616412.2025.2472824","url":null,"abstract":"<p><strong>Objectives: </strong>Approximately 25% of individuals experience various symptoms months after the COVID-19 infection and are referred to as having Long-COVID syndrome. The primary objective of this study was to identify the pattern of neuropsychiatric symptoms and their influence on psychological health, sleep quality, and overall well-being.</p><p><strong>Methods: </strong>In this cross-sectional study, Long-COVID patients reported on their symptoms by using a predefined list. The symptom patterns were examined using cluster analysis. The clustering groups were compared based on psychological health, sleep, and well-being scores obtained from structured questionnaires.</p><p><strong>Results: </strong>There were 40 females and 13 males, with a mean age of 54.1 ± 12.2 years. The most frequently reported symptoms were fatigue (94.3%), followed by anxiety (79.2%), myalgias (75.5%), and concentration difficulties (71.7%). Clustering analysis revealed two clusters separated by the number of cognitive, psychiatric, general neurologic, and somatic symptoms (i.e. high and low number). Patients within the high number cluster reported significantly more symptoms of depression, anxiety and stress, and worse quality of sleep than the low number cluster. Overall, 32 patients (60.4%) were found to have poor well-being. Reporting more than 17 symptoms (58.6% of patients) predicted poor well-being with a sensitivity of 37.5% and specificity of 95.2% (<i>p</i> = 0.011).</p><p><strong>Discussion: </strong>In this study, Long-COVID patients presenting at the outpatient neurologic clinic were clustered based on the number of symptoms instead of the nature of these symptoms. A higher number of symptoms were associated with poorer psychological health, sleep quality, and overall well-being.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"251-257"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study.","authors":"Aysu Yetis, Asuman Celikbilek, Bilal Ilanbey, Naime Meric Konar, Selcen Duran","doi":"10.1080/01616412.2025.2472836","DOIUrl":"10.1080/01616412.2025.2472836","url":null,"abstract":"<p><strong>Objective: </strong>Neurofilament light chain (NfL) has emerged as a promising biomarker for several neurological diseases. Therefore, we investigated its serum levels and their association with disease characteristics, including duration, severity, and medication use in patients with restless legs syndrome (RLS).</p><p><strong>Method: </strong>This cross-sectional prospective study included 71 RLS patients and 70 healthy controls. RLS patients were characterized based on disease duration, severity, and medication use. NfL levels were quantified using commercial enzyme-linked immunosorbent assay kits.</p><p><strong>Result: </strong>No significant differences in NfL levels were observed between RLS patients and controls (<i>p</i> > 0.05). Furthermore, the levels were not significantly associated with disease duration or severity in RLS patients (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>These findings do not support the use of NfL as a biomarker for RLS. Further large-scale studies are needed to evaluate its role in RLS.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"284-289"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education level and health profile related to global cognitive impairment in an urban community in West Jakarta, Indonesia.","authors":"Yvonne Suzy Handajani, Yuda Turana, Kevin Kristian, Nelly Tina Widjaja, Aylenia Lysandra, Elisabeth Schröder-Butterfill, Antoninus Hengky","doi":"10.1080/01616412.2025.2470709","DOIUrl":"10.1080/01616412.2025.2470709","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the association of global cognitive with chronic conditions, physical impairment, olfactory function, socio-demographics and other factors among older adults in the urban community, West Jakarta.</p><p><strong>Materials and methods: </strong>The cross-sectional study involved 334 older adults aged 60 years and older who resided in urban community Jakarta, Indonesia. Trained interviewers visited and evaluated the respondents in the sub-district office. Cognitive function is examined using Montreal Cognitive Assessment-Indonesian Version (MoCA-INA). Respondents were clinically examined using a standardized protocol, which included medical history, general physical examination, cognitive assessment, and blood test for diabetes.</p><p><strong>Results: </strong>Global cognitive impairment was significantly associated with being female (adjusted odd ratio [AOR]: 1.99, 95% CI: 1.14-3.50) and low education (AOR: 4.79, 95% CI: 2.80-8.18). Moreover diabetes, impaired balance, and olfactory dysfunction have AOR:3.23 (95% CI: 1.39-7.51), 2.55% (95% CI: 1.07-6.07), and 2.26 (95% CI: 1.32-3.85) respectively.</p><p><strong>Conclusion: </strong>This paper highlights that cognitively impaired and diabetic as well as low education subject in urban community, West Jakarta, Indonesia. Global cognitive impairment was associated with being female, having obtained low levels of education, having diabetes, impaired balance and olfactory dysfunction.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"223-231"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}