Neurological Research最新文献

{"title":"Short-term outcomes of atrial fibrillation patients undergoing carotid stent placement or carotid endarterectomy in the United States.","authors":"Adnan I Qureshi, Hatem Tolba, Mohammed Sulaiman Khan, Camilo R Gomez, Chun Shing Kwok","doi":"10.1080/01616412.2025.2496929","DOIUrl":"10.1080/01616412.2025.2496929","url":null,"abstract":"<p><strong>Background: </strong>Patients with atrial fibrillation (AF) were excluded from the trials evaluating carotid artery stent placement (CAS) or carotid endarterectomy (CEA). We identified the prevalence of atrial fibrillation and how it might be associated with outcomes in patients with symptomatic internal carotid artery (ICA) stenosis.</p><p><strong>Methods: </strong>We analyzed the data from the National Inpatient Sample between 2016 and 2021 with stenosis of ICA who underwent CAS or CEA. We compared the end points of intra- and post-procedural cerebral infarction, hemorrhage, discharge home and death based on the presence or absence of AF. We also compared the outcomes in AF patients who had CAS with those who had CEA.</p><p><strong>Results: </strong>Atrial fibrillation was present in 3,785 (18.3%) of 20,645 patients who underwent either CAS or CEA between 2016 and 2021, while 16,860 did not have atrial fibrillation. The proportion of patients who developed acute myocardial infarction, respiratory failure, acute kidney injury, or required blood transfusion was higher in patients with atrial fibrillation among both CAS- and CEA-treated patients. There was no difference in odds of post-procedural stroke and/or death in patients with atrial fibrillation (compared with those without atrial fibrillation) who were treated with CAS (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.62-1.60, <i>p</i> = 0.98) and those treated with CEA (OR 1.09, 95% CI 0.69-1.73, <i>p</i> = 0.72 in the multivariate analysis after adjusting for potential confounders. The length of stay and hospitalization cost were significantly higher in patients with atrial fibrillation. There was no difference in post-procedural stroke and/or death (10.7% versus 8.7%, <i>p</i> = 0.41) and discharge home (32.4% versus 26.8%, <i>p</i> = 0.13) in patients with atrial fibrillation who underwent CEA compared to those who underwent CAS in propensity-matched analysis.</p><p><strong>Conclusion: </strong>One in five patients with symptomatic ICA stenosis who undergo CAS or CEA have AF. We did not identify higher risk of post-procedural stroke and/or death irrespective of the procedure, but resource utilization was higher in AF patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"658-665"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of wake-up stroke: a systematic review and meta-analysis.","authors":"Yuting Zhao, Jia Li, Ying Zhu, Qiuxia Qian, Xiaoling Qian, Longchun Hua, Jianxun Cao, Yuxia Ma","doi":"10.1080/01616412.2025.2534517","DOIUrl":"https://doi.org/10.1080/01616412.2025.2534517","url":null,"abstract":"<p><strong>Background: </strong>Wake-up stroke (WUS) is a subgroup of ischemic stroke in which patients show no abnormality before sleep, while wake up with neurological deficits, and the prevalence varied widely across studies. To obtain a true estimate of WUS, we conducted a systematic review and meta-analysis of previously published data.</p><p><strong>Methods: </strong>PubMed, the Cochrane Library, Web of Science, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure Database (CNKI), Wanfang Database and Weipu Database (VIP) were searched from their inception through 1 April 2025 to identify population-based, observational studies that reported the prevalence of WUS.</p><p><strong>Results: </strong>The meta-analysis included 37 studies involving 196,744 individuals. The pooled prevalence of WUS was 23.1% (95% CI: 21.1%-25.1%, I² = 98.8%). The results of the subgroup analysis showed that the pooled prevalence of WUS was 22.8% (95% CI: 21%-25%) in women and 24% (95% CI: 22%-26%) in men. The pooled prevalence of WUS based on the cross-sectional studies and cohort studies, respectively, was 25.1% (95% CI: 23%-27%) and 17.4% (95% CI: 15%-20%). Based on the regional analysis, the prevalence of WUS was 25% (95% CI: 23%-27%) in Asia, 18.5% (95% CI: 14%-22%) in Europe, and 24.1% (95% CI: 18%-31%) in North America.</p><p><strong>Conclusions: </strong>The prevalence of WUS is 23.1%, with higher rates observed in men and the Asian region. Increased awareness and training among healthcare professionals are essential for early recognition, potentially improving diagnosis and management in emergency settings. Promoting education on WUS is also vital for reducing associated morbidity and mortality.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal expression of miR-136-5p in glioma cancer patients and its correlation with CT signs.","authors":"Jiaxin Yin, Xiang Zhang","doi":"10.1080/01616412.2025.2532818","DOIUrl":"https://doi.org/10.1080/01616412.2025.2532818","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRNAs) have attracted considerable attention as promising new tumor biomarkers.</p><p><strong>Aims: </strong>This study primarily integrates computed tomography (CT) findings to investigate the expression and potential implications of miR-136-5p in glioma.</p><p><strong>Methods: </strong>Human glioma samples were obtained from 122 glioma tissues and 80 adjacent tissues resected by surgery from confirmed patients. Reverse transcription quantitative PCR (RT-qPCR) was used to detect the expression of the genes. Receiver Operating Characteristic (ROC) curve was used to evaluate the diagnostic value of miR-136-5p combined with Computed Tomography (CT) in glioma. Correlation analysis was conducted employing Pearson's method. The target genes of miR-136-5p were identified using the TargetScan online database and validated through dual luciferase reporter assays.</p><p><strong>Results: </strong>In glioma tissues, the expression of miR-136-5p was markedly downregulated. Its expression correlates with CT signs and clinicopathological features of glioma patients. Both CT detection and miR-136-5p expression showed significant potential in diagnosing glioma, and combining the two improved the diagnostic value of glioma. Furthermore, the overexpression of miR-136-5p has been shown to negatively regulate the expression of the BCL9L gene in U87 and U251 glioma cell lines, thereby inhibiting tumor cell proliferation and promoting apoptotic processes.</p><p><strong>Conclusions: </strong>miR-136-5p is downregulated in glioma tissues and closely correlates with tumor CT signs. It may serve as a promising biomarker to assist in glioma diagnosis using CT scans.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous sinus stenting for idiopathic intracranial hypertension in the MENA region: initial results from the VEHICLE Registry.","authors":"Ossama Yassin Mansour, Aser Goma, Jaidaa Mekky, Mohamed Shafik, Farid Aladham, Ibrahim Alnaami, Hosam Maher Al-Jehani, Abdulrahman Alshamy, Faisal Alghamdi, Ozlem Aykac, Mohamed Khaled Elwia, Hany El Hamadani, Mehdi Farhodi, Mahmoud Galal, Mohamed Ghorbani, Erdem Gurkas, Nadia Hammami, Mohamed Hamdy, Tamer Hassan, Farouk Hassan, Syed I Hussain, Yahia Imam, Seby John, Wael Khalifa, Amina El Khamlichi, Amr Mahmoud, Mostafa Mahmoud, Ehab S Mohamed, Nada Nasr, Atilla Ozcan Ozdemir, Umair Rashid, Salma Said, Abdulmonem Saied, Mohammed Wasay, Hany Zaki Eldeen","doi":"10.1080/01616412.2025.2533420","DOIUrl":"https://doi.org/10.1080/01616412.2025.2533420","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical outcomes and safety of venous sinus stenting in idiopathic intracranial hypertension (IIH) patients across multiple centers in the Middle East and North Africa (MENA) region through the Venous stEnt for idiopathic intraCranial hypertEnsion (VEHICLE) Registry.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of prospectively collected data from the VEHICLE Registry (NCT06692790) between August 2023 and August 2024. From an initial pool of 187 cases, 100 patients met all inclusion criteria: IIH diagnosis based on modified Dandy criteria, neuroimaging-confirmed venous sinus stenosis, refractory or intolerant to medical therapy, underwent venous pressure manometry, and had complete follow-up data. All patients underwent venous sinus stenting at nine collaborating centers.</p><p><strong>Results: </strong>Of 100 patients, 73% were female. All presented with headaches, while 87% reported visual disturbances. Venous stenoses predominantly affected the right transverse sinus (56%). At six months, 83% achieved marked symptom resolution, 80% had normalized optic nerve heads, and stent patency was confirmed in 90%. Papilledema grades improved significantly from median Grade III at baseline to Grade I at 6 months (<i>p</i> < 0.001), correlating with increased QOL scores (<i>p</i> < 0.001). Sixteen percent required revision procedures. Complication rates were low, with no procedure-related mortality.</p><p><strong>Discussion: </strong>Significant improvements in headache, papilledema, and quality of life were observed with a favorable safety profile with venous sinus stenting for medically refractory IIH. However, the retrospective design and lack of a control group limit definitive conclusions about efficacy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue and its contributing factors in people with multiple sclerosis: a cross-sectional study.","authors":"Ida Mohammadi, Saeed Vaheb, Shahryar Rajai Firouzabadi, Mohammad Yazdan Panah, Vahid Shaygannejad, Omid Mirmosayyeb","doi":"10.1080/01616412.2025.2537328","DOIUrl":"https://doi.org/10.1080/01616412.2025.2537328","url":null,"abstract":"<p><strong>Background: </strong>Fatigue is a common and debilitating symptom in people with multiple sclerosis (PwMS), yet its contributing factors are not fully understood. This study examined how fatigue severity relates to physical activity, limb function, mood, and demographics within a unified framework.</p><p><strong>Methods: </strong>In this cross-sectional study, PwMS were recruited in Isfahan, Iran, from April 2023 to April 2024. Participants completed the Fatigue Severity Scale, and data were collected on demographics, cognitive processing speed (Symbol Digit Modalities Test), physical activity (IPAQ), upper limb function (9-Hole Peg Test), lower limb function (Timed 25-Foot Walk), depression, and anxiety (Beck inventories). Associations between fatigue severity and these factors were analyzed using stepwise linear and logistic regression models.</p><p><strong>Results: </strong>Among 141 participants (90.1% female; mean age: 37.87 ± 9.74 years), fatigue prevalence was 61.7%. Higher fatigue severity was significantly associated with greater depression (B (95% CI) = 0.47 (0.32, 0.63), β = 0.481), poorer lower limb function (B (95% CI) = 1.82 (0.48, 3.16), β = 0.234), progressive MS (B (95% CI) = 7.38 (1.85, 12.91), β = 0.186), and lower physical activity (B (95% CI) = -0.0006 (-0.001, -0.0001), β = -0.156). Logistic regression indicated that being married (OR (95% CI) = 3.06 (1.20, 7.80), worse lower limb function (OR (95% CI) = 1.55 (1.01, 2.37), and higher depression scores (OR (95% CI) = 1.06 (1.01, 1.10) were associated with increased odds of clinically significant fatigue.</p><p><strong>Conclusion: </strong>Fatigue was common among PwMS and was independently associated with depression, reduced lower extremity function, progressive MS, lower physical activity, and marital status. These findings highlight key physical and psychological factors associated with fatigue; however, longitudinal studies are needed to establish causality.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPEDITION: an Exploratory deep learning method to quantitatively predict hematoma progression after intracerebral hemorrhage.","authors":"Siqi Chen, Zixiao Li, Yinsheng Li, Donghua Mi","doi":"10.1080/01616412.2025.2536668","DOIUrl":"https://doi.org/10.1080/01616412.2025.2536668","url":null,"abstract":"<p><strong>Objects: </strong>This study aims to develop an Exploratory deep learning method to quantitatively predict hematoma progression (EXPEDITION in short) after intracerebral hemorrhage (ICH).</p><p><strong>Methods: </strong>Patients with primary ICH in the basal ganglia or thalamus were retrospectively enrolled, and their baseline non-contrast CT (NCCT) image, CT perfusion (CTP) images, and subsequent re-examining NCCT images from the 2nd to the 8th day after baseline CTP were collected. The subjects who had received three or more re-examining scans were categorized into the test data set, and others were assigned to the training data set. Hematoma volume was estimated by manually outlining the lesion shown on each NCCT scan. Cerebral venous hemodynamic feature was extracted from CTP images. Then, EXPEDITION was trained. The Bland-Altman analysis was used to assess the prediction performance.</p><p><strong>Results: </strong>A total of 126 patients were enrolled initially, and 73 patients were included in the final analysis. They were then categorized into the training data set (58 patients with 93 scans) and the test data set (15 patients with 50 scans). For the test set, the mean difference [mean ±1.96SD] of hematoma volume between the EXPEDITION prediction and the reference is -0.96 [-9.64, +7.71] mL. Specifically, in the test set, the consistency between the true and the predicted volume values was compared, indicating that the EXPEDITION achieved the needed accuracy for quantitative prediction of hematoma progression.</p><p><strong>Conclusions: </strong>An Exploratory deep learning method, EXPEDITION, was proposed to quantitatively predict hematoma progression after primary ICH in basal ganglia or thalamus.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: regarding the article \"efficacy and safety of hematopoietic and mesenchymal stem cells in multiple sclerosis: a meta-analysis\".","authors":"Murat Kürtüncü","doi":"10.1080/01616412.2025.2534518","DOIUrl":"https://doi.org/10.1080/01616412.2025.2534518","url":null,"abstract":"","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the relationship between autoimmune neurologic diseases and mental disorders: evidence from Mendelian randomization study.","authors":"Yu Shen, WenWen Xiang, Qun Xiong, Si Luo, Hao Chen, Ziwei Song, Yusen Qiu, Lijun Pang, Daojun Hong","doi":"10.1080/01616412.2025.2534082","DOIUrl":"https://doi.org/10.1080/01616412.2025.2534082","url":null,"abstract":"<p><strong>Introduction: </strong>Traditional epidemiologic studies suggest that autoimmune neurologic diseases may be associated with mental disorders (MDs). We used Mendelian randomization (MR) studies to explore the causal relationship between autoimmune neurologic diseases and MDs from the genetic perspective.</p><p><strong>Methods: </strong>In our study, autoimmune neurologic diseases include multiple sclerosis (MS), neuromyelitis optica (NMO), and myasthenia gravis (MG); MDs include anxiety, major depressive disorder (MDD), attention deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar affective disorder (BIP). A two-sample MR approach was used to explore causal relationships. The inverse variance weighted (IVW) method was the primary method for MR analysis. In addition, we included all MG datasets for meta-analysis after MR analysis with ADHD.</p><p><strong>Results: </strong>Regarding the causal effects of MDs on autoimmune neurologic diseases, our analyses revealed a causal relationship between genetically predicted ADHD and MG (OR 2.250; 95% CI 1.267-3.998; <i>p</i> = 0.006), and no potential genetic causal relationships were found between the other diseases. However, according to the MR‒Egger analysis, there was no indication of directional pleiotropy. For the causal effects of autoimmune neurologic diseases on MDs, no potential genetic causal relationships were identified between any of the diseases. We performed a meta-analysis for MG and ADHD, there was no significant genetic causal relationship between ADHD and MG (OR 1.30 (95% CI 0.95-1.79); <i>p</i> = 0.10).</p><p><strong>Conclusion: </strong>This study revealed that there was no genetic mechanism linking autoimmune neurologic diseases and MDs to each other. These findings provide a foundation for the prevention and treatment of comorbid conditions in clinical research.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of tramadol and levetiracetam in preventing peridural fibrosis after laminectomy in rats.","authors":"Ibrahim Umud Bulut, Ulas Yuksel, Bahar Kartal, Asli Fahriye Ceylan, Mustafa Ilker Karagedik, Alemiddin Ozdemir, Mustafa Ogden, Bulent Bakar","doi":"10.1080/01616412.2025.2538130","DOIUrl":"https://doi.org/10.1080/01616412.2025.2538130","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the therapeutic effects of tramadol hydrochloride and levetiracetam on preventing peridural fibrosis after laminectomy in rats.</p><p><strong>Methods: </strong>Under sedation anesthesia, standard laminectomies at T9, T10, and T11 were performed on 32 male Wistar albino rats weighing 300-350 g. The rats were then divided into groups: Sham (no pharmacological agent administered, <i>n</i> = 6 + 2); MP group (10 mg/kg/day methylprednisolone sodium succinate administered intraperitoneally for 14 days, <i>n</i> = 6 + 2); TRA group (0.6 mg/kg/day tramadol hydrochloride administered intraperitoneally for 14 days, <i>n</i> = 6 + 2); and LEV group (15 mg/kg/day levetiracetam administered intraperitoneally for 14 days, <i>n</i> = 6 + 2). Four weeks after surgery, all animals were euthanized, and their spinal columns were removed en bloc. Peridural fibrosis and collagen density were evaluated using hematoxylin-eosin and Masson-Trichrome staining, respectively. Collagen and alpha-SMA levels were assessed with COL1A1 and ACTA2 staining, respectively. ELISA measurements were taken for TNF-α, IL-6, TGF-ß, CTGF, caspase-3, and GSH/GSSG levels. Western blot analysis was performed to determine pAMPK, mTOR, pmTOR, and mTOR/p-mTOR levels.</p><p><strong>Results: </strong>Histopathological and immunohistochemical analyses showed that methylprednisolone and tramadol reduced peridural fibrosis, collagen density, and collagen formation. Both agents exhibited anti-inflammatory and anti-apoptotic effects by decreasing TNF-α, IL-6, caspase-3, TGF-β, and CTGF levels. They demonstrated antioxidant properties by increasing GSH/GSSG levels, and they supported autophagy by increasing pAMPK and decreasing pmTOR levels.</p><p><strong>Conclusion: </strong>In summary, all three agents possessed anti-inflammatory, antioxidant, anti-apoptotic, and autophagy-associated tissue regenerative properties. Due to these effects, they have the potential to reduce peridural fibrosis in the rat laminectomy model.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-17"},"PeriodicalIF":1.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of bundle-based preventive care on healthcare-associated infection control in neurosurgical patients.","authors":"Xiaowei Xu, Liqin Wei, Weiwei Wang, Yu Sun, Li Zheng, Yan Wang","doi":"10.1080/01616412.2025.2537329","DOIUrl":"https://doi.org/10.1080/01616412.2025.2537329","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the effects of bundle-based preventive care on the control of healthcare-associated infections (HAIs) in patients undergoing neurosurgical procedures.</p><p><strong>Methods: </strong>One hundred and twenty patients who underwent neurosurgery were enrolled and randomly assigned, using a random number table method, to either the control group (<i>n</i> = 60), which received routine nursing care, or the observation group (<i>n</i> = 60), which bundle-based preventive care. The incidence of HAIs, antibiotic usage, and pathogen detection rates were compared between the two groups. In addition, adverse events and length of hospital stay were recorded. Nursing quality and patient satisfaction were also evaluated.</p><p><strong>Results: </strong>The observation group showed significantly better outcomes than the control group. Specifically, its HAI rate (6.67% vs. 21.67%) and total pathogen detection rate (6.67% vs. 20.00%) were significantly lower (<i>p</i> < 0.05). The use of dual and triple antibiotic regimens was also reduced (<i>p</i> < 0.05). Moreover, the observation group experienced fewer adverse events and a shorter hospital stay (<i>p</i> < 0.05). Nursing quality scores - including hand hygiene, disinfection and isolation, nursing communication, and documentation - were all higher in the observation group (<i>p</i> < 0.05). Patient satisfaction was significantly improved as well (95.00% vs. 83.33%, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Bundle-based preventive care can effectively reduce postoperative HAIs and antibiotic usage in neurosurgical patients, lower the incidence of adverse events, and significantly improve nursing quality and patient satisfaction.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}