Neurological Research最新文献_第2页

Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis. 与二硫化相关的免疫检查点基因CD276参与胶质母细胞瘤恶性表型和不良预后的形成。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-13 DOI: 10.1080/01616412.2025.2476506

Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui

{"title":"Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis.","authors":"Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui","doi":"10.1080/01616412.2025.2476506","DOIUrl":"https://doi.org/10.1080/01616412.2025.2476506","url":null,"abstract":"Background: Immunotherapy has promise for glioblastoma multiforme (GBM) treatment and disulfidptosis, a form of cell death involving disintegration of the actin cytoskeleton, is a potential target. The aim of the current study was to identify genes associated with disulfidptosis-related immune checkpoints in GBM and to analyze connections with malignancy.Methods: Two expression matrices from The Cancer Genome Atlas-Genotype Tissue Expression (TCGA-GTEx) and Chinese Glioma Genome Atlas (CGGA) cyber public data were utilized to analyze differentially expressed genes (DEGs) in GBM and interaction networks for DEG-coded proteins constructed with protein-protein interaction network analysis. Functional annotation was conducted to indicate DEG function. Hub genes were identified by machine-learning, using Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine Recursive Feature Elimination (SVM-RFE). Gene expression, immune cell composition and single-cell expression were assessed via bioinformatics and in vitro assays. Finally, xenograft nude mouse models were constructed for in vivo validation.Results: 35 DEGs were found in the TCGA-GTEx and 13 in the CGGA databases and linked to immune regulation and GBM progression. The key gene CD276 was screened by bioinformatics methods. CD276 had higher expression in GBM tissues than in control and was higher expression in GBM strain than in normal astrocytes. In vitro CD276 knockdown reduced GBM cell malignancy. Furthermore, CD276 knockdown suppressed tumor growth in vivo.Conclusion: CD276 was the most significant hub gene involved in disulfidptosis and immune checkpoints in GBM. Anti-CD276 therapy may have promise for GBM treatment.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-12 DOI: 10.1080/01616412.2025.2477240

Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao

{"title":"Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.","authors":"Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao","doi":"10.1080/01616412.2025.2477240","DOIUrl":"https://doi.org/10.1080/01616412.2025.2477240","url":null,"abstract":"Background: While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted.Methods: In our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties, vegetarian foods, cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases. In MR analysis, we employed multiple Mendelian randomization techniques such as MR-Egger, Inverse Variance Weighted methods and rigorously controlled the false discovery rates through the Bonferroni correction across 10 dietary exposures.Results: Our analysis identified a significant association between cooked vegetables (OR: 9.939; 95% CI: 2.066 ~ 47.822; p = 0.0042) and an elevated risk of intracranial aneurysms. Besides, the initial analysis suggested a statistically significant association between the dried fruit (OR: 0.385; 95%CI: 0.159 ~ 0.935; p = 0.0350), frequency of alcohol intake (OR: 1.419; 95% CI: 1.039 ~ 1.937; p = 0.0276) and the risk of intracranial aneurysms. However, this significance was not sustained after applying the Bonferroni correction for multiple testing, indicating a need for cautious interpretation despite the initially promising findings.Conclusion: This study identified a clear causal link between cooked vegetable intake and an increased risk of intracranial aneurysm, while suggesting a potential connection between the frequency of alcohol intake and the elevated risk, although this association did not reach statistical significance after multiple testing corrections.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-06 DOI: 10.1080/01616412.2025.2476515

Meihua Sun, Mingli Ge, Qinglin Shen

{"title":"Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.","authors":"Meihua Sun, Mingli Ge, Qinglin Shen","doi":"10.1080/01616412.2025.2476515","DOIUrl":"https://doi.org/10.1080/01616412.2025.2476515","url":null,"abstract":"Objective: To investigate the clinical effectiveness of acupoint injection in the treatment of acute phase of peripheral facial paralysis (PFP).Methods: A total of 85 patients with PFP were randomly divided into the control group, which was treated by prednisone acetate; the thermal design power (TDP) group, which was treated with acupuncture plus specific electromagnetic spectrum irradiation; and the acupoint injection group, which was treated with acupuncture plus specific electromagnetic spectrum irradiation combined with vitamin B1 (Vit B1) and vitamin B12 (Vit B12) acupoint injection. The treatment effectiveness was evaluated by Portmann score of facial paralysis, House-Brackmann (H-B) facial nerve function grading, serum levels of IL-6, IL-1β, and TNF-α, the cure time, and total effective rate.Results: The scores of Portmann and H-B in the TDP group were significantly higher than the control group, and the acupoint injection group was higher than the TDP group after each course of treatment (p < 0.05). The time to produce a significant effectiveness was shortened in the order of the acupoint injection group > the TDP group > the control group (p < 0.05). The cure rate was higher in the acupoint injection group (100%) than the TDP group (72.41%) and control group (67.86%) (p < 0.05). The serum levels of IL-6, IL-1β and TNF-α were obviously lower in the TDP group than the control group and in the acupoint injection group were lower than the TDP group (p < 0.05).Conclusion: Acupoint injection can significantly improve the curative effect, shorten the cure time, reduce the level of serum inflammatory factors, and promote the recovery of facial nerve function in the acute stage of PFP.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can lactate levels predict progression to status epilepticus in generalized convulsive epileptic seizures?

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-06 DOI: 10.1080/01616412.2025.2472829

İhsan Dengiz, Selen Acehan, Salim Satar, Muge Gulen, Sarper Sevdimbas, Mert Pehlivan, Melike Kucukceylan, Mehmet Gorur, Ali İsa Aslan, Figen Topalak

{"title":"Can lactate levels predict progression to status epilepticus in generalized convulsive epileptic seizures?","authors":"İhsan Dengiz, Selen Acehan, Salim Satar, Muge Gulen, Sarper Sevdimbas, Mert Pehlivan, Melike Kucukceylan, Mehmet Gorur, Ali İsa Aslan, Figen Topalak","doi":"10.1080/01616412.2025.2472829","DOIUrl":"https://doi.org/10.1080/01616412.2025.2472829","url":null,"abstract":"Objective: The aim of this study was to analyze the factors predicting the progression to status epilepticus (SE) in patients who presented with generalized convulsive epileptic (GCE) seizures.Materials and methods: Patients included in the study were grouped as SE (+) and (-) patients. In addition to hemogram, biochemistry and blood gas parameters, the levels of antiepileptic drugs used by the patients at the time of presentation to the emergency department (ED) were also studied. Blood gas parameters at the 2nd hour of follow-up were retaken and lactate clearance was calculated and recorded on the data form.Results: 26.7% of the patients were SE (+). A statistically significant, moderate correlation was observed between postictal time and both lactate0(r = 0.663; p < 0.001) and lactate2levels (r = 0.626; p < 0.001). In the analyses performed for the association with the presence of SE, presence of seizures within the last week (OR: 17.15, 95% CI: 1.322-222.505, p = 0.030), lactate2(OR: 2.055, 95% CI: 1.367-3.090, p = 0.001), lactate0(OR: 1.520, 95% CI: 1.030-1.283, p = 0.006), pulse rate (OR: 1.150, 95% CI: 1.150, 95% CI: 11.012-3.054, p = 0. 045) and leukocyte (OR: 0.469, 95% CI: 0.254-0.868, p = 0.016) values were independent predictors of the presence of SE. In the ROC analysis, it was determined that lactate0value had the highest predictive power (AUC: 0.908, 95% GA 0.860-0.955, p < 0.001).Conclusion: According to the study data, the presence of a significant increase in lactate levels at emergency department presentation should alert the clinician to status epilepticus.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-05 DOI: 10.1080/01616412.2025.2472828

Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge

{"title":"F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?","authors":"Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge","doi":"10.1080/01616412.2025.2472828","DOIUrl":"https://doi.org/10.1080/01616412.2025.2472828","url":null,"abstract":"Objectives: Motor unit number estimation (MUNE) methods including the one using F-waves (F-MUNE) are used to detect axonal loss in polyneuropathies. The aim of this study is to evaluate the amount of axonal loss by repeater F-wave parameters and F-MUNE in patients with type 2 diabetes mellitus (DM).Methods: In 24 controls and 49 patients with diabetic polyneuropathy, 90 F-waves elicited with supramaximal and 300 F-waves with submaximal stimulation of the ulnar nerve were recorded from the abductor digiti minimi muscle. F-MUNE values were calculated using the automated software with the repeater F-waves elicited using submaximal stimulation.Results: Ulnar repeater F-wave index and repeater neuron index were found to be significantly higher in patients with DM compared with the control group. The amplitudes of F-waves elicited using both sub- and supramaximal stimulus intensities were reduced in patients with polyneuropathy when compared with controls. The F-MUNE values were found to be similar between the two groups.Discussion: Repeater F-wave parameters recorded from the upper extremity might indicate the presence of axon loss in DM-related polyneuropathy. However, F-MUNE failed to reveal axonal loss in diabetic polyneuropathy probably because of its length-dependent nature and the dominance of low-amplitude F-waves, which might be secondary to several yet unknown mechanisms, mainly related to sensory fiber dysfunction.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-05 DOI: 10.1080/01616412.2025.2472841

Afef Achouri-Rassas, Saloua Fray, Zakaria Said, Samia Ben Sassi, Nadia Ben Ali, Ghada Baraket

{"title":"Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population.","authors":"Afef Achouri-Rassas, Saloua Fray, Zakaria Said, Samia Ben Sassi, Nadia Ben Ali, Ghada Baraket","doi":"10.1080/01616412.2025.2472841","DOIUrl":"https://doi.org/10.1080/01616412.2025.2472841","url":null,"abstract":"Background: Alzheimer's disease (AD) is the leading cause of major neurodegenerative cognitive impairment. The risk of developing AD is influenced by a complex interaction of genetic predisposition and environmental factors. Among the genetic risk factors, the APOE ɛ4 allele is the most significant, while variants in the TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) and ABCA7 (ATP-binding cassette transporter A7) genes have also been associated with an increased risk of AD.Objective: This study aimed to investigate the association of APOE ɛ4, TREM2 gene variants (rs75932628 [p.R47H] and rs2234253 [p.T96K]), and ABCA7 gene variants (rs142076058 and rs115550680) with sporadic AD in the Tunisian population. Methods: A case-control study was conducted including 222 Tunisian patients diagnosed with sporadic AD and 99 cognitively healthy controls. Genotyping was performed to assess the presence and association of the selected genetic variants with AD. Statistical analyses were conducted to determine the significance of genetic associations.Results: A significant association was found between the TREM2 rs2234253 (p.T96K) variant and AD, with the T allele identified as a risk factor in the Tunisian population. The APOE ɛ4 allele was also associated with an increased risk of developing AD. However, no significant association was observed for the ABCA7 gene variants or the TREM2 rs75932628 (p.R47H) variant in either the AD or control groups.Conclusion: Our findings suggest that the TREM2 rs2234253 (p.T96K) variant is a significant genetic risk factor for late-onset AD (LOAD) in the Tunisian population. Further studies with larger cohorts are needed to validate these findings and explore potential gene-gene interactions contributing to AD risk.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-05 DOI: 10.1080/01616412.2025.2472843

Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa

{"title":"U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.","authors":"Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa","doi":"10.1080/01616412.2025.2472843","DOIUrl":"https://doi.org/10.1080/01616412.2025.2472843","url":null,"abstract":"Background: Body mass index (BMI) is associated with the sites of intracerebral hemorrhage (ICH), which affect functional decline. However, the optimal BMI range for minimizing functional decline remains unclear. This study aimed to clarify the relationship between BMI and ICH-related functional decline.Methods: ICH survivors registered in the Japanese Registry Of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database from April 2016 to March 2020 were included. BMI was categorized according to the World Health Organization Asia-Pacific classification. The primary outcome was ICH-related functional decline, defined as an increase in the modified Rankin Scale (mRS) score at discharge compared to pre-stroke.Results: This study included 155,211 patients with ICH, with a mean BMI of 22.3 kg/m2. Among these patients, 74.1% experienced ICH-related functional decline. The overweight group (23.0 < BMI ≤ 25.0 kg/m2) exhibited the lowest rate of functional decline (Odds ratio: 0.90, 95% CI: 0.85-0.94). The relationship between BMI and ICH-related functional decline followed a U-shaped curve, indicating that a BMI range of 22.2-30.4 kg/m2 was associated with reduced odds of functional decline.Conclusion: In patients with ICH, both extremely low and high BMIs were associated with a higher likelihood of functional decline post-ICH onset. Maintaining a BMI within the range of 22.2-30.4 kg/m2 may be beneficial for reducing the risk of functional decline.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of memantine and donepezil on social memory, anxiety-like behavior and the expression levels of microRNA-124, microRNA-125b, and microRNA-132 in scopolamine-induced memory impairment in rats.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-03 DOI: 10.1080/01616412.2025.2472848

Pouria Bahmani Kolour, Hamed Ghazvini, Mobin Naderi, Hossein Ghalehnoei, Masoumeh Rezaei Talarposhti

{"title":"Effects of memantine and donepezil on social memory, anxiety-like behavior and the expression levels of microRNA-124, microRNA-125b, and microRNA-132 in scopolamine-induced memory impairment in rats.","authors":"Pouria Bahmani Kolour, Hamed Ghazvini, Mobin Naderi, Hossein Ghalehnoei, Masoumeh Rezaei Talarposhti","doi":"10.1080/01616412.2025.2472848","DOIUrl":"https://doi.org/10.1080/01616412.2025.2472848","url":null,"abstract":"Introduction: Almost all physiological processes are modulated by microRNAs, therefore, dysregulation of these small regulatory RNAs is observed in a variety of diseases, including cognitive impairments.Methods: In this study, 40 male Wistar rats were randomly divided into five groups of control, scopolamine, donepezil, memantine, and combined administration of donepezil + memantine. Rats in scopolamine, donepezil, memantine, and combined administration of donepezil + memantine groups received scopolamine (1 mg/kg-intraperitoneal) for 7 days. After the last administration of scopolamine, was started injecting donepezil (3 mg/kg-i.p.), memantine (10 mg/kg-i.p.), and combined administration of Donepezil + Memantine (0.5 mg/kg and 5 mg/kg-i.p., respectively), up to 21 days. Twenty-four hours after the last injection, elevated plus-maze, social interaction, open field tests, and gene expression analysis of miR-124, miR-125b, and miR-132 in the hippocampus were carried out.Results: The results of the behavioral tests indicate that donepezil and memantine significantly prevented Scopolamine-induced anxiety, sociability, and social memory decline. The gene expression of selected microRNAs did not significantly differ between the groups.Discussion: This study revealed that donepezil and memantine effectively prevent synaptic plasticity disruption and cognitive decline induced by scopolamine. Findings indicated that this treatment is unrelated to the expression of the selected microRNAs. The positive effects of memantine and donepezil depend on age, dosages, cognitive task demands, and possibly the length and timing of the treatment.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The correlation between vitamin B12 serum levels and migraine: a case-control study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/01616412.2025.2462735

Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed

{"title":"The correlation between vitamin B12 serum levels and migraine: a case-control study.","authors":"Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed","doi":"10.1080/01616412.2025.2462735","DOIUrl":"10.1080/01616412.2025.2462735","url":null,"abstract":"Objectives: Migraine represents the prevailing form of primary headache with no fully described etiology and pathophysiology. This study aimed to assess the association between vitamin B12 serum levels and both chronic and episodic migraine.Patients and methods: This study was conducted as a case-control study, including 90 migraineurs, divided into 48 with episodic migraine and 42 with chronic migraine as the case group, and 90 matched healthy participants as the control group. The serum level of vitamin B12 was measured using enzyme-linked immunosorbent assay (ELISA) for all subjects. Its association with the Migraine Disability Assessment (MIDAS) scale and migraine attack severity, measured using the Visual Analog Scale (VAS), was analyzed.Results: Migraineurs exhibited a notable reduction in serum vitamin B12 levels compared to the control group (243.97 ± 124.85 pg/ml vs. 302.69 ± 143.69 pg/ml, p = 0.014). Furthermore, chronic migraine patients had significantly lower serum vitamin B12 levels when compared to episodic migraine patients (202.7 ± 75.62 pg/ml vs. 269.17 ± 143.31 pg/ml, p = 0.026). A significant negative correlation was found between serum vitamin B12 levels and the severity of migraine attacks, as measured by the VAS (r = -0.407, p = 0.036).Conclusion: The current study highlighted that vitamin B12 deficiency is highly associated with migraine and its severity. Further interventional research is highly recommended to investigate the potential causality of this association.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"195-200"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1080/01616412.2025.2462734

Seval Yilmaz, Nezehat Özgül Ünlüer

{"title":"The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients.","authors":"Seval Yilmaz, Nezehat Özgül Ünlüer","doi":"10.1080/01616412.2025.2462734","DOIUrl":"10.1080/01616412.2025.2462734","url":null,"abstract":"Background: Multiple sclerosis (MS) affects muscle strength and postural stability. However, the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS is not well known. The aim of the study was to examine the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS patients.Materials and methods: The study included 21 mild-stage MS patients with an EDSS score of 4 or less and 21 healthy controls. The concentric and isometric strength of knee flexors and extensors was measured with the Biodex System 4 Dynamometer, and postural stability with the Biodex Balance System under eyes-open and eyes-closed conditions on a rigid surface.Results: Mild-stage MS patients had reduced concentric strength of knee extensors and flexors and increased postural sway compared with healthy controls (p < 0.05). Isometric strength of knee extensors and flexors in mild stage MS patients were similar to healthy controls (p > 0.05). There was a moderate positive correlation between concentric strength of knee extensors and flexors and isometric strength of knee flexors and open-eye postural stability indexes in mild stage multiple sclerosis patients (p < 0.05).Conclusions: While isometric strength of knee extensors and flexors was preserved, concentric strength of knee extensors and flexors was decreased, and postural stability was adversely affected in mild stage MS patients. The increase in the strength of the knee muscles was associated with an increase in their postural sway in mild stage MS patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"188-194"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0