Neurological Research最新文献

{"title":"Static postural balance and manual dexterity are sex-dependent among a sample of relapsing-remitting multiple sclerosis patients.","authors":"Sonda Jallouli, Sameh Ghroubi, Imen Ben Dhia, Salma Sakka, Mariem Damak, Bedreddine Jaafar, Abdelmoneem Yahia, Mohamed Habib Elleuch, Chokri Mhiri, Omar Hammouda","doi":"10.1080/01616412.2025.2484426","DOIUrl":"https://doi.org/10.1080/01616412.2025.2484426","url":null,"abstract":"<p><strong>Background: </strong>Sex differences in physical, psycho-cognitive and sleep disorders, neuropathic pain and perceived fatigue related to multiple sclerosis (MS) have been studied, but contradictory findings were found. MS studies regarding difference between men and women in postural balance are very scarce and based on subjective assessments. We aimed to investigate the sex difference effects on postural balance and other physical measures among a sample of MS patients.</p><p><strong>Methods: </strong>Data from 8 men and 12 women with MS were compared. The assessed parameters were: static and dynamic postural balance (force platform), manual dexterity (Nine Hole Peg Test (NHPT)), leg muscle strength (Five-Repetition Sit-To-Stand Test), functional mobility (Timed up and Go Test), walking speed (Timed 25-Foot Walk Test), fall risk (Four Square Step Test), cognitive functions (Montreal cognitive assessment (MOCA) and React software), neuropathic pain (Neuropathic Pain Questionnaire 4 (DN4)), perceived fatigue (Hooper index), mood (Hospital Anxiety and Depression Scale), and sleep quality (Spiegel's questionnaire).</p><p><strong>Results: </strong>The center of pressure mean velocity was higher in women than in men in the static condition with eyes closed (<i>p</i> = 0.041, Hedges'g (g) = 0.71). Women showed lower MoCA scores (<i>p</i> = 0.028, g = 1.06) as well as higher NHPT duration (<i>p</i> = 0.002, g = 1.64) (in the dominant hand) and DN4 scores (<i>p</i> = 0.003, g = 1.59) than men. No significant sex differences were found for the remaining parameters.</p><p><strong>Conclusion: </strong>Based on this study among a sample of MS patients, women showed poorer static postural balance and manual dexterity than men probably due to their higher neuropathic pain and cognitive decline. These sex differences should be considered when organizing therapeutic training programs for this population.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-COVID from the perspective of neurologists at the outpatient clinic: A cross-sectional field study.","authors":"Artemios Artemiadis, Andreas G Tofarides, Andreas Liampas, Christiana Ioannou, Katerina Christodoulou, Rafaela Louka, George Vavougios, Panagiotis Zis, Panagiotis Bargiotas, Georgios Hadjigeorgiou","doi":"10.1080/01616412.2025.2472824","DOIUrl":"10.1080/01616412.2025.2472824","url":null,"abstract":"<p><strong>Objectives: </strong>Approximately 25% of individuals experience various symptoms months after the COVID-19 infection and are referred to as having Long-COVID syndrome. The primary objective of this study was to identify the pattern of neuropsychiatric symptoms and their influence on psychological health, sleep quality, and overall well-being.</p><p><strong>Methods: </strong>In this cross-sectional study, Long-COVID patients reported on their symptoms by using a predefined list. The symptom patterns were examined using cluster analysis. The clustering groups were compared based on psychological health, sleep, and well-being scores obtained from structured questionnaires.</p><p><strong>Results: </strong>There were 40 females and 13 males, with a mean age of 54.1 ± 12.2 years. The most frequently reported symptoms were fatigue (94.3%), followed by anxiety (79.2%), myalgias (75.5%), and concentration difficulties (71.7%). Clustering analysis revealed two clusters separated by the number of cognitive, psychiatric, general neurologic, and somatic symptoms (i.e. high and low number). Patients within the high number cluster reported significantly more symptoms of depression, anxiety and stress, and worse quality of sleep than the low number cluster. Overall, 32 patients (60.4%) were found to have poor well-being. Reporting more than 17 symptoms (58.6% of patients) predicted poor well-being with a sensitivity of 37.5% and specificity of 95.2% (<i>p</i> = 0.011).</p><p><strong>Discussion: </strong>In this study, Long-COVID patients presenting at the outpatient neurologic clinic were clustered based on the number of symptoms instead of the nature of these symptoms. A higher number of symptoms were associated with poorer psychological health, sleep quality, and overall well-being.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"251-257"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education level and health profile related to global cognitive impairment in an urban community in West Jakarta, Indonesia.","authors":"Yvonne Suzy Handajani, Yuda Turana, Kevin Kristian, Nelly Tina Widjaja, Aylenia Lysandra, Elisabeth Schröder-Butterfill, Antoninus Hengky","doi":"10.1080/01616412.2025.2470709","DOIUrl":"10.1080/01616412.2025.2470709","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the association of global cognitive with chronic conditions, physical impairment, olfactory function, socio-demographics and other factors among older adults in the urban community, West Jakarta.</p><p><strong>Materials and methods: </strong>The cross-sectional study involved 334 older adults aged 60 years and older who resided in urban community Jakarta, Indonesia. Trained interviewers visited and evaluated the respondents in the sub-district office. Cognitive function is examined using Montreal Cognitive Assessment-Indonesian Version (MoCA-INA). Respondents were clinically examined using a standardized protocol, which included medical history, general physical examination, cognitive assessment, and blood test for diabetes.</p><p><strong>Results: </strong>Global cognitive impairment was significantly associated with being female (adjusted odd ratio [AOR]: 1.99, 95% CI: 1.14-3.50) and low education (AOR: 4.79, 95% CI: 2.80-8.18). Moreover diabetes, impaired balance, and olfactory dysfunction have AOR:3.23 (95% CI: 1.39-7.51), 2.55% (95% CI: 1.07-6.07), and 2.26 (95% CI: 1.32-3.85) respectively.</p><p><strong>Conclusion: </strong>This paper highlights that cognitively impaired and diabetic as well as low education subject in urban community, West Jakarta, Indonesia. Global cognitive impairment was associated with being female, having obtained low levels of education, having diabetes, impaired balance and olfactory dysfunction.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"223-231"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study.","authors":"Aysu Yetis, Asuman Celikbilek, Bilal Ilanbey, Naime Meric Konar, Selcen Duran","doi":"10.1080/01616412.2025.2472836","DOIUrl":"10.1080/01616412.2025.2472836","url":null,"abstract":"<p><strong>Objective: </strong>Neurofilament light chain (NfL) has emerged as a promising biomarker for several neurological diseases. Therefore, we investigated its serum levels and their association with disease characteristics, including duration, severity, and medication use in patients with restless legs syndrome (RLS).</p><p><strong>Method: </strong>This cross-sectional prospective study included 71 RLS patients and 70 healthy controls. RLS patients were characterized based on disease duration, severity, and medication use. NfL levels were quantified using commercial enzyme-linked immunosorbent assay kits.</p><p><strong>Result: </strong>No significant differences in NfL levels were observed between RLS patients and controls (<i>p</i> > 0.05). Furthermore, the levels were not significantly associated with disease duration or severity in RLS patients (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>These findings do not support the use of NfL as a biomarker for RLS. Further large-scale studies are needed to evaluate its role in RLS.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"284-289"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.","authors":"Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa","doi":"10.1080/01616412.2025.2472843","DOIUrl":"10.1080/01616412.2025.2472843","url":null,"abstract":"<p><strong>Background: </strong>Body mass index (BMI) is associated with the sites of intracerebral hemorrhage (ICH), which affect functional decline. However, the optimal BMI range for minimizing functional decline remains unclear. This study aimed to clarify the relationship between BMI and ICH-related functional decline.</p><p><strong>Methods: </strong>ICH survivors registered in the Japanese Registry Of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database from April 2016 to March 2020 were included. BMI was categorized according to the World Health Organization Asia-Pacific classification. The primary outcome was ICH-related functional decline, defined as an increase in the modified Rankin Scale (mRS) score at discharge compared to pre-stroke.</p><p><strong>Results: </strong>This study included 155,211 patients with ICH, with a mean BMI of 22.3 kg/m². Among these patients, 74.1% experienced ICH-related functional decline. The overweight group (23.0 < BMI ≤ 25.0 kg/m²) exhibited the lowest rate of functional decline (Odds ratio: 0.90, 95% CI: 0.85-0.94). The relationship between BMI and ICH-related functional decline followed a U-shaped curve, indicating that a BMI range of 22.2-30.4 kg/m² was associated with reduced odds of functional decline.</p><p><strong>Conclusion: </strong>In patients with ICH, both extremely low and high BMIs were associated with a higher likelihood of functional decline post-ICH onset. Maintaining a BMI within the range of 22.2-30.4 kg/m² may be beneficial for reducing the risk of functional decline.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"296-305"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of the AMPK signaling pathway in preventing CCI-induced neuropathy in rats: focus on anti-inflammatory effects.","authors":"Amin Hasanvand, Maryam Ghandinezhad, Mohammadjavad Nourmohammadi, Fatemeh Hatami, Behrouz Beiranvand, Zahra Haghighatian, Peyman Amanolahi Baharvand, Ali Kharazmkia","doi":"10.1080/01616412.2025.2486523","DOIUrl":"https://doi.org/10.1080/01616412.2025.2486523","url":null,"abstract":"<p><strong>Objective: </strong>It has been shown that the AMPK signaling pathway helps maintain the structure of nerve cells and prevent damage caused by hypoxia by preserving the energy available in these cells. This signaling pathway is activated by various drugs, including metformin.</p><p><strong>Methods: </strong>In this study, thirty male rats were randomly divided into healthy rats, CCI (chronic constriction injury), CCI + metformin, CCI + dorsomorphin, and CCI + metformin + dorsomorphin groups. Behavioral tests were performed on the third, seventh, and fourteenth days after the induction of CCI. On the last day, the inflammatory cytokines and pathology were investigated after dissecting the spinal cords and sciatic nerves of the animals, respectively.</p><p><strong>Results: </strong>The results of this study indicated that metformin could improve performance in behavioral tests and reduce the levels of inflammatory cytokines. Histological analyses further revealed that metformin could decrease inflammation and necrosis in sciatic nerve tissue. Notably, this effect was observed despite dorsomorphin injection, which prevented the therapeutic effects of metformin in the fifth group.</p><p><strong>Conclusion: </strong>The results of this study indicated that stimulation of the AMPK signaling pathway could effectively preserve the structure of the sciatic nerve, reduce inflammation, and improve responses to behavioral tests.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate dietary flavonoid intake associated with lower prevalence of Parkinson's disease: data from the NHANES 2007-2010 and 2017-2018.","authors":"Shanshan Gong, Yuchang Fei","doi":"10.1080/01616412.2025.2482753","DOIUrl":"https://doi.org/10.1080/01616412.2025.2482753","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between dietary flavonoids and the prevalence of PD.</p><p><strong>Methods: </strong>We used data from the 2007-2010 and 2017-2018 National Health and Nutrition Examination Survey (NHANES). Dietary flavonoid intake was assessed through a two-day, 24-hour dietary recall method, and PD diagnosis was ascertained by the presence of 'Anti-Parkinson agents' among the reported prescription medications. Logistic regression, subgroup, and restricted cubic spline (RCS) models were employed to analyze the connection between dietary flavonoids and PD prevalence.</p><p><strong>Results: </strong>Our study revealed a correlation between the consumption of dietary total flavonoids, flavan-3-ols, and flavonols, and PD risk. Subgroup analysis indicated a negative correlation of dietary flavan-3-ols and total flavonoids with PD risk only among non-obese participants. Furthermore, our analysis using RCS demonstrated a nonlinear association between dietary flavonoids, flavan-3-ols, flavonols, and PD prevalence. We found that the optimal intake of total flavonoids, flavan-3-ols and flavonols wase 403.65 mg/day,346 mg/day and 26.74 mg/day, respectively. Above these thresholds, the risk of developing PD is elevated.</p><p><strong>Conclusions: </strong>Our study highlights a significant association between moderate dietary intake of total flavonoids, flavan-3-ols, and flavonols, and a reduced risk of PD. Our work may provide new therapeutic ideas for the prevention and treatment of PD and provide dietary flavonoid intake recommendations for PD patients.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histone demethylase KDM6B promotes glioma cell proliferation by increasing <i>PDGFRA</i> expression via chromatin loop formation.","authors":"Aixia Sui, Xiaoqiang Guo","doi":"10.1080/01616412.2025.2480326","DOIUrl":"https://doi.org/10.1080/01616412.2025.2480326","url":null,"abstract":"<p><strong>Objectives: </strong>Changes in gene expression pattern play an essential role in promoting the process of cancer. For example, platelet-derived growth factor receptor alpha (<i>PDGFRA</i>) is overexpressed in many cancers, including gliomas. Abnormal histone methylation is a typical characteristics of glioma, and our previous studies have shown that histone lysine demethylase 6B (KDM6B) is involved in glioma development by regulating the expression of specific oncogenes. In this study, the regulatory effect and underlying mechanism of KDM6B on <i>PDGFRA</i> expression were investigated.</p><p><strong>Methods: </strong>The expression information of KDM6B and <i>PDGFRA</i> in patients with glioma was analyzed in GEPIA database. The expression or activity of KDM6B was regulated with CRISPR interference/activation (CRISPRi/a) assays, gene knockdown and specific inhibitor. Cell proliferation was determined using cell counting kit assay. Chromatin immunoprecipitation assay (ChIP) and ChIP-loop assays were used to determine the H3K27me3 status in the <i>PDGFRA</i> promoter and DNA-DNA interactions mediated by KDM6B.</p><p><strong>Results: </strong>The expression of KDM6B and <i>PDGFRA</i> expression is positively correlated in gliomas. CRISPRi/a assays indicated that KDM6B has a positive regulatory role in <i>PDGFRA</i> expression in glioma cells and can promote glioma cell proliferation. KDM6B knockdown and inhibitor assays further proved that KDM6B promotes <i>PDGFRA</i> expression. ChIP assays indicated KDM6B reduces H3K27me3 level in the <i>PDGFRA</i> promoter. The ChIP-loop assays showed KDM6B increases the formation of chromatin loops, which facilitates the proximity of enhancer and promoter.</p><p><strong>Conclusion: </strong>This study reveals a new epigenetic mechanism of <i>PDGFRA</i> overexpression in glioma cells, that is, KDM6B catalyzes the demethylation of H3K27me3 and induces chromatin loop formation to activate <i>PDGFRA</i> expression. This study is of great significance for the understanding of glioma development and the application of new treatment strategies, such as radiation therapy combined with epigenetic therapy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical presentations of post ischemic and post traumatic brain injury scars associated seizures.","authors":"Vishal Chavda, Vimal Patel, Parmar Harisinh Vajesinh, Manuel De Jesus Encarnacion Ramirez, Gervith Reyes-Soto, Creed M Stary, Nicola Montemurro","doi":"10.1080/01616412.2025.2482755","DOIUrl":"https://doi.org/10.1080/01616412.2025.2482755","url":null,"abstract":"<p><strong>Objectives: </strong>Deep scarring inside the temporal lobe of the brain commonly causes focal seizures and structural epilepsy. Temporal herniation/protrusion including encephaloceles deduced by head and skull injury causes refractory epilepsy. In addition to debilitating seizures, epilepsy can cause cognitive and emotional problems with reduced quality of life.</p><p><strong>Methods: </strong>The major aim is to prevent the disorder in the first place: identify, detect, and reverse the processes responsible for its onset, and monitor and treat its progression.</p><p><strong>Results: </strong>Epilepsy often occurs following a latent period of months to years (epileptogenesis) because of brain insults, such as head trauma, stroke, or status epilepticus. Although this latent period clearly represents a therapeutic window, we are not able to stratify patients at risk for long-term epilepsy, which is prerequisite for preventative clinical trials. Moreover, because of the length of the latent period, an early biomarker for treatment response would be of high value. Finally, mechanistic biomarkers of epileptogenesis may provide more profound insight into the process of disease development.</p><p><strong>Discussion: </strong>This review discussed the pathophysiology associated with glial cells in scar epileptogenesis, neurological manifestations, clinical interventions, and current diagnostic and therapeutic approaches.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced expression of miR-128 in peripheral blood mononuclear cells: a potent candidate diagnostic biomarker for multiple sclerosis.","authors":"Hossein Akhgari, Alireza Ahmadi, Abedeh Rezaei, Ali Mohammadi, Reza Safaralizadeh","doi":"10.1080/01616412.2025.2481443","DOIUrl":"https://doi.org/10.1080/01616412.2025.2481443","url":null,"abstract":"<p><strong>Objectives: </strong>Millions of people worldwide, especially young adults, are affected by multiple sclerosis (MS), a demyelinating and autoimmune condition of the central nervous system (CNS). Many studies have focused on the diagnostic value of miRNAs circulating in body fluids of MS patients. Thus, this study aimed to assess the expression of miR-128 and its potential as a biomarker for MS in the Iranian population.</p><p><strong>Methods: </strong>This study recruited 85 MS patients and 30 healthy matched controls. Following the collection of blood samples, serum was isolated. RNA was then extracted, cDNA was synthesized, and miR-128 expression was measured by real-time PCR.</p><p><strong>Results: </strong>There was significant overexpression of miR-128 in MS patients in comparison with healthy controls (p-value <0.0001). In addition, there was a rather notable association between the subtypes of MS samples and the expression levels of miR-128. ROC analysis showed an AUC of 0.9111 (95%CI 0.85-0.97, p-value <0.0001) with sensitivity and specificity of 80.00% and 93.33%, respectively.</p><p><strong>Conclusion: </strong>The expression of miR-128 was significantly higher in PBMCs of MS patients in comparison with healthy controls. Additionally, miR-128 could be an excellent biomarker for MS patient diagnosis.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}