Neurological Research最新文献_第3页

Relationship between sympathetic skin response and RR interval variation with the prognosis of Guillain-Barre syndrome patients. 交感神经皮肤反应和 RR 间期变化与格林-巴利综合征患者预后的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-21 DOI: 10.1080/01616412.2025.2476514

Behnaz Ansari, Mahdiyeh Gholipoor Khotbesara, Keivan Basiri

{"title":"Relationship between sympathetic skin response and RR interval variation with the prognosis of Guillain-Barre syndrome patients.","authors":"Behnaz Ansari, Mahdiyeh Gholipoor Khotbesara, Keivan Basiri","doi":"10.1080/01616412.2025.2476514","DOIUrl":"https://doi.org/10.1080/01616412.2025.2476514","url":null,"abstract":"Background: Guillain-Barré syndrome (GBS) is an inflammatory disorder causing severe disability and death. The sympathetic skin response (SSR) and RR interval variability are non-invasive tests that measure autonomic dysfunction. The aim of this study was to investigate the relationship of SSR and RR interval variation with prognosis in patients with GBS in Isfahan, Iran.Methods: This cross-sectional study analyzed 32 patients with GBS in Iran between 2023 and 2024. Patients underwent EMG-NCV during their hospitalization, measuring SSR and RR interval variation. Patients' GBS disability scores were calculated and recorded on the day of hospital discharge and one month after. Gender distribution, types of GBS, intubation status, length of ICU and ward stay, GBS disability scores, and plasmapheresis volume are also compared.Results: In 19 patients (59.3%), both SSR and RR interval variability were abnormal. There were no statistically significant differences between patients with and without autonomic dysfunction (AD) for the variables compared. There were no significant differences between groups with normal and abnormal SSR and between groups with normal and abnormal RR interval variation. Age and intubation status significantly affect GBS disability scores at discharge and one month after discharge, while gender does not significantly impact any outcomes. Many variables, such as age, gender, type of GBS, intubation status, and lengths of stay, do not show significant differences between the compared groups based on AD, SSR, and RR interval variability.Conclusions: The study highlights the lack of correlation between AD, SSR, and RR interval variation in patients with GBS.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is artificial intelligence successful in the Turkish neurology board exam?

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-20 DOI: 10.1080/01616412.2025.2481444

Ayse Betul Acar, Ece Yanik, Emine Altin, Ozlem Kurtkaya Kocak

{"title":"Is artificial intelligence successful in the Turkish neurology board exam?","authors":"Ayse Betul Acar, Ece Yanik, Emine Altin, Ozlem Kurtkaya Kocak","doi":"10.1080/01616412.2025.2481444","DOIUrl":"https://doi.org/10.1080/01616412.2025.2481444","url":null,"abstract":"Objectives: OpenAI declared that GPT-4 performed better in academic and certain specialty areas. Medical licensing exams assess the clinical competence of doctors. We aimed to investigate for the first time howChatGPT will perform in the Turkish Neurology Proficiency Exam.Methods: TheGPT-4 version of ChatGPT was used in the study due to the presence ofimage-based questions. The multiple-choice sections of the TurkishNeurology Proficiency Exams conducted by the Turkish NeurologyAssociation (TND) in 2021, 2022 and 2023 were applied to ChatGPT-4.Questions and multiple-choice answers were used in their originalTurkish forms in the official national examination standards.Results: The success rate in all three exams ranges from 79% to 82%. There were common and different mistakes in the two trials. When the incorrect answers were re-evaluated, the correct answers were obtained.Conclusions: This is the first study to investigate the performance of ChatGPT on the real Neurology Proficiency Examination. The success rate was shown to be above GPT-3.5. Furthermore, this study showed that translating questions from the original language into English did not affect the performance of GPT-4 in medical licensing exams, unlike GPT-3.5. It is therefore very important that the information obtained is accurate and verifiable. ChatGPT-4's ability to find the correct answer with feedback on questions that it initially answered incorrectly may be due to the model's ability to generate flexible and adaptive answers.These models should be used carefully and consciously, knowing that they will not always give the correct answer.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-4"},"PeriodicalIF":1.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Six-spot step test under three different task conditions to assess dual-task ability in people with multiple sclerosis.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-19 DOI: 10.1080/01616412.2025.2480325

Özge Ertekin, Zuhal Abasıyanık, Turhan Kahraman, Seda Daştan, Serkan Özakbaş

{"title":"Six-spot step test under three different task conditions to assess dual-task ability in people with multiple sclerosis.","authors":"Özge Ertekin, Zuhal Abasıyanık, Turhan Kahraman, Seda Daştan, Serkan Özakbaş","doi":"10.1080/01616412.2025.2480325","DOIUrl":"https://doi.org/10.1080/01616412.2025.2480325","url":null,"abstract":"Background: The Six-Spot Step Test (SSST) is a valid measure to assess the ability of people with multiple sclerosis (pwMS) to maintain balance whilst challenging stability during walking. This study aimed to compare the performance of three different SSST conditions in pwMS and healthy controls (HC) and to explore whether incorporating cognitive tasks into the SSST improves its discriminative capacity by increasing cognitive load.Methods: Fifty-two pwMS (median EDSS = 1.75) and 19 HC were recruited. Participants performed the SSST under three different task conditions: conventional SSST, SSST with word-list generation task (WLG), and SSST with the serial-7 backward task. The dual-task cost (DTC) was calculated for two cognitive task conditions.Results: There was a significant difference across different SSST conditions in both groups. There was also significant condition*group interaction [F (2,132) = 3.69, p = 0.028, η2 = 0.053]. PwMS completed all SSST conditions in a longer duration compared to HC. The DTC of SSST with backward and WLG tasks was greater in the MS group than in HC. However, there was no significant differences in the number of correct answers during the dual-task conditions between pwMS and HC. All three conditions showed excellent discriminative ability between pwMS and HC (Area Under Curve value > 0.8).Significance: The SSST had the ability to discriminate between pwMS and HC in both conventional method and with secondary cognitive task. The SSST could be used to evaluate early walking and dual-task deficits even in pwMS with mild disability for future research and clinical practice.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term effects of various exercise training modalities on balance, gait and fatigue in patients with multiple sclerosis: a randomized controlled study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-19 DOI: 10.1080/01616412.2025.2481427

Hakan Polat, Serkan Usgu

{"title":"Long-term effects of various exercise training modalities on balance, gait and fatigue in patients with multiple sclerosis: a randomized controlled study.","authors":"Hakan Polat, Serkan Usgu","doi":"10.1080/01616412.2025.2481427","DOIUrl":"https://doi.org/10.1080/01616412.2025.2481427","url":null,"abstract":"Objective: To investigate the long-term effects of vestibular exercises (VE), cervical stabilization exercises (CSE) and standard balance exercises (SBE) on balance, gait and fatigue in patients with multiple sclerosis.Methods: Thirty-five patients were randomly allocated to three groups, performing different exercises three days a week for 12 weeks. Assessments were conducted at baseline, at Week 12 and at a 6-month follow-up using the Functional Reach Test (FRT), Four-Square Step Test (FSST), 2-Minute Walk Test (2MWT), Timed Up and Go (TUG) test, and Fatigue Impact Scale (FIS).Results: At 12 weeks, both CSE and VE groups improved on FRT and 2MWT, with the CSE group also experiencing improvements on FSST, TUG, and FIS (p < 0.05). The SBE group showed no significant changes. At 6 months, FRT, FSST, and 2MWT improvements persisted in the VE group, while the CSE group-maintained TUG and FIS gains. The VE group had superior FRT at 6 months, while the CSE group showed greater FSST improvements at 12 weeks. The VE group exhibited greater 2MWT improvements than the CSE group at 6 months, while the CSE group had better TUG results at both timepoints. Both CSE and VE groups showed greater reductions in fatigue (FIS) than the SBE group at 6 months.Discussion: VE provide long-term benefits for balance and gait speed, while CSE enhance gait endurance and postural control during training. Both modalities contribute to long-term fatigue reduction. SBE are less effective, highlighting the need for targeted interventions such as VE and CSE for sustained improvements.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between serum GDF15 levels and non-motor symptoms in Parkinson's disease.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-18 DOI: 10.1080/01616412.2025.2480331

Jianli Wang, Ting Geng, Xiaomei Yao, Yiming Liu

{"title":"The relationship between serum GDF15 levels and non-motor symptoms in Parkinson's disease.","authors":"Jianli Wang, Ting Geng, Xiaomei Yao, Yiming Liu","doi":"10.1080/01616412.2025.2480331","DOIUrl":"10.1080/01616412.2025.2480331","url":null,"abstract":"Objectives: The primary aim was to investigate the relationship between serum growth differentiation factor-15 (GDF15) levels and non-motor symptom (NMS) in Parkinson's disease (PD) patients. The secondary aim was to explore the diagnostic value of GDF15 for specific NMS.Methods: A total of 102 PD patients were enrolled in this study, including 47 males and 55 females. Doctors collected the clinical and demographic information of patients and detected the level of serum GDF15. Next, linear univariate and multivariate linear regression analyses were used to assess the correlation between GDF15 and NMS. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off value of GDF15 and evaluate its diagnostic value.Results: In PD patients, there was no significant difference in serum GDF15 levels between males and females (p = 0.831). Age of PD onset, pesticide use, depression, sexual dysfunction, Epworth Sleepiness Scale (ESS) and Hamilton Depression Scale (HAMD) were associated with serum GDF15. Serum GDF15 was negatively correlated with HAMD, depression and sexual dysfunction and positively correlated with ESS. Each 10 pg/ml increase in serum GDF15 levels was associated with a 4% lower risk of depression and a 5% lower risk of sexual dysfunction. Notably, serum GDF15 may be a biomarker for distinguishing depression and sexual dysfunction in PD patients.Conclusion: Elevated serum GDF15 reduced the risk of PD with depression and sexual dysfunction. Serum GDF15 may be a biomarker for distinguishing depression and sexual dysfunction in PD patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis. 与二硫化相关的免疫检查点基因CD276参与胶质母细胞瘤恶性表型和不良预后的形成。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-13 DOI: 10.1080/01616412.2025.2476506

Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui

{"title":"Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis.","authors":"Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui","doi":"10.1080/01616412.2025.2476506","DOIUrl":"https://doi.org/10.1080/01616412.2025.2476506","url":null,"abstract":"Background: Immunotherapy has promise for glioblastoma multiforme (GBM) treatment and disulfidptosis, a form of cell death involving disintegration of the actin cytoskeleton, is a potential target. The aim of the current study was to identify genes associated with disulfidptosis-related immune checkpoints in GBM and to analyze connections with malignancy.Methods: Two expression matrices from The Cancer Genome Atlas-Genotype Tissue Expression (TCGA-GTEx) and Chinese Glioma Genome Atlas (CGGA) cyber public data were utilized to analyze differentially expressed genes (DEGs) in GBM and interaction networks for DEG-coded proteins constructed with protein-protein interaction network analysis. Functional annotation was conducted to indicate DEG function. Hub genes were identified by machine-learning, using Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine Recursive Feature Elimination (SVM-RFE). Gene expression, immune cell composition and single-cell expression were assessed via bioinformatics and in vitro assays. Finally, xenograft nude mouse models were constructed for in vivo validation.Results: 35 DEGs were found in the TCGA-GTEx and 13 in the CGGA databases and linked to immune regulation and GBM progression. The key gene CD276 was screened by bioinformatics methods. CD276 had higher expression in GBM tissues than in control and was higher expression in GBM strain than in normal astrocytes. In vitro CD276 knockdown reduced GBM cell malignancy. Furthermore, CD276 knockdown suppressed tumor growth in vivo.Conclusion: CD276 was the most significant hub gene involved in disulfidptosis and immune checkpoints in GBM. Anti-CD276 therapy may have promise for GBM treatment.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-12 DOI: 10.1080/01616412.2025.2477240

Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao

{"title":"Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.","authors":"Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao","doi":"10.1080/01616412.2025.2477240","DOIUrl":"https://doi.org/10.1080/01616412.2025.2477240","url":null,"abstract":"Background: While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted.Methods: In our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties, vegetarian foods, cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases. In MR analysis, we employed multiple Mendelian randomization techniques such as MR-Egger, Inverse Variance Weighted methods and rigorously controlled the false discovery rates through the Bonferroni correction across 10 dietary exposures.Results: Our analysis identified a significant association between cooked vegetables (OR: 9.939; 95% CI: 2.066 ~ 47.822; p = 0.0042) and an elevated risk of intracranial aneurysms. Besides, the initial analysis suggested a statistically significant association between the dried fruit (OR: 0.385; 95%CI: 0.159 ~ 0.935; p = 0.0350), frequency of alcohol intake (OR: 1.419; 95% CI: 1.039 ~ 1.937; p = 0.0276) and the risk of intracranial aneurysms. However, this significance was not sustained after applying the Bonferroni correction for multiple testing, indicating a need for cautious interpretation despite the initially promising findings.Conclusion: This study identified a clear causal link between cooked vegetable intake and an increased risk of intracranial aneurysm, while suggesting a potential connection between the frequency of alcohol intake and the elevated risk, although this association did not reach statistical significance after multiple testing corrections.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-06 DOI: 10.1080/01616412.2025.2476515

Meihua Sun, Mingli Ge, Qinglin Shen

{"title":"Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.","authors":"Meihua Sun, Mingli Ge, Qinglin Shen","doi":"10.1080/01616412.2025.2476515","DOIUrl":"https://doi.org/10.1080/01616412.2025.2476515","url":null,"abstract":"Objective: To investigate the clinical effectiveness of acupoint injection in the treatment of acute phase of peripheral facial paralysis (PFP).Methods: A total of 85 patients with PFP were randomly divided into the control group, which was treated by prednisone acetate; the thermal design power (TDP) group, which was treated with acupuncture plus specific electromagnetic spectrum irradiation; and the acupoint injection group, which was treated with acupuncture plus specific electromagnetic spectrum irradiation combined with vitamin B1 (Vit B1) and vitamin B12 (Vit B12) acupoint injection. The treatment effectiveness was evaluated by Portmann score of facial paralysis, House-Brackmann (H-B) facial nerve function grading, serum levels of IL-6, IL-1β, and TNF-α, the cure time, and total effective rate.Results: The scores of Portmann and H-B in the TDP group were significantly higher than the control group, and the acupoint injection group was higher than the TDP group after each course of treatment (p < 0.05). The time to produce a significant effectiveness was shortened in the order of the acupoint injection group > the TDP group > the control group (p < 0.05). The cure rate was higher in the acupoint injection group (100%) than the TDP group (72.41%) and control group (67.86%) (p < 0.05). The serum levels of IL-6, IL-1β and TNF-α were obviously lower in the TDP group than the control group and in the acupoint injection group were lower than the TDP group (p < 0.05).Conclusion: Acupoint injection can significantly improve the curative effect, shorten the cure time, reduce the level of serum inflammatory factors, and promote the recovery of facial nerve function in the acute stage of PFP.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The correlation between vitamin B12 serum levels and migraine: a case-control study.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/01616412.2025.2462735

Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed

{"title":"The correlation between vitamin B12 serum levels and migraine: a case-control study.","authors":"Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed","doi":"10.1080/01616412.2025.2462735","DOIUrl":"10.1080/01616412.2025.2462735","url":null,"abstract":"Objectives: Migraine represents the prevailing form of primary headache with no fully described etiology and pathophysiology. This study aimed to assess the association between vitamin B12 serum levels and both chronic and episodic migraine.Patients and methods: This study was conducted as a case-control study, including 90 migraineurs, divided into 48 with episodic migraine and 42 with chronic migraine as the case group, and 90 matched healthy participants as the control group. The serum level of vitamin B12 was measured using enzyme-linked immunosorbent assay (ELISA) for all subjects. Its association with the Migraine Disability Assessment (MIDAS) scale and migraine attack severity, measured using the Visual Analog Scale (VAS), was analyzed.Results: Migraineurs exhibited a notable reduction in serum vitamin B12 levels compared to the control group (243.97 ± 124.85 pg/ml vs. 302.69 ± 143.69 pg/ml, p = 0.014). Furthermore, chronic migraine patients had significantly lower serum vitamin B12 levels when compared to episodic migraine patients (202.7 ± 75.62 pg/ml vs. 269.17 ± 143.31 pg/ml, p = 0.026). A significant negative correlation was found between serum vitamin B12 levels and the severity of migraine attacks, as measured by the VAS (r = -0.407, p = 0.036).Conclusion: The current study highlighted that vitamin B12 deficiency is highly associated with migraine and its severity. Further interventional research is highly recommended to investigate the potential causality of this association.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"195-200"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients.

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1080/01616412.2025.2462734

Seval Yilmaz, Nezehat Özgül Ünlüer

{"title":"The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients.","authors":"Seval Yilmaz, Nezehat Özgül Ünlüer","doi":"10.1080/01616412.2025.2462734","DOIUrl":"10.1080/01616412.2025.2462734","url":null,"abstract":"Background: Multiple sclerosis (MS) affects muscle strength and postural stability. However, the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS is not well known. The aim of the study was to examine the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS patients.Materials and methods: The study included 21 mild-stage MS patients with an EDSS score of 4 or less and 21 healthy controls. The concentric and isometric strength of knee flexors and extensors was measured with the Biodex System 4 Dynamometer, and postural stability with the Biodex Balance System under eyes-open and eyes-closed conditions on a rigid surface.Results: Mild-stage MS patients had reduced concentric strength of knee extensors and flexors and increased postural sway compared with healthy controls (p < 0.05). Isometric strength of knee extensors and flexors in mild stage MS patients were similar to healthy controls (p > 0.05). There was a moderate positive correlation between concentric strength of knee extensors and flexors and isometric strength of knee flexors and open-eye postural stability indexes in mild stage multiple sclerosis patients (p < 0.05).Conclusions: While isometric strength of knee extensors and flexors was preserved, concentric strength of knee extensors and flexors was decreased, and postural stability was adversely affected in mild stage MS patients. The increase in the strength of the knee muscles was associated with an increase in their postural sway in mild stage MS patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"188-194"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0