Galadu Subah, Rohan Patel, Ariel Sacknovitz, Michael Fortunato, Zachary Vazquez, Yomna Hammouda, Anaz Uddin, Austin Li, Aiden K Lui, Sunny Chi, Kevin Clare, Esewi Aifuwa, Jude Al-Mufti, Brittany Russo, Ahya Ali, Hosam Al-Jehani, Chaitanya Medicherla, Sarah C Parauda, Stephanie Gandelman, Stephan Mayer, Chirag Gandhi, Fawaz Al-Mufti
{"title":"A nationwide analysis of acute ischemic stroke in intravascular large B-cell lymphoma: the needle in a haystack.","authors":"Galadu Subah, Rohan Patel, Ariel Sacknovitz, Michael Fortunato, Zachary Vazquez, Yomna Hammouda, Anaz Uddin, Austin Li, Aiden K Lui, Sunny Chi, Kevin Clare, Esewi Aifuwa, Jude Al-Mufti, Brittany Russo, Ahya Ali, Hosam Al-Jehani, Chaitanya Medicherla, Sarah C Parauda, Stephanie Gandelman, Stephan Mayer, Chirag Gandhi, Fawaz Al-Mufti","doi":"10.1080/01616412.2025.2554920","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>A significantly increased risk of cerebrovascular disease (CVD) is well documented among patients diagnosed with various malignancies. Cancer patients face nearly double the risk of acute ischemic stroke (AIS) compared to the general population. Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of non-Hodgkin B-cell lymphoma characterized by the proliferation of neoplastic lymphoma cells within the vasculature of organs. Occurring in <0.5 per 1,000,000 persons, it is exceptionally rare. This study investigates AIS occurrence in IVLBCL patients.</p><p><strong>Methods: </strong>The National Inpatient Sample (NIS) was queried from the period of 2010-2019 using the International Classification of Diseases (ICD) 9th and 10th edition codes to identify patients admitted for AIS either with or without IVLBCL.</p><p><strong>Results: </strong>We identified 44 cases of IVLBCL among 705,928 AIS patients. We found that IVLBCL patients who experienced AIS were generally older (74.5 vs. 70.15 years, <i>p</i> < 0.0001), had less severe strokes (0.33 vs. 0.47, <i>p</i> < 0.01), longer hospital stays (12.22 vs. 5.99 days, <i>p</i> < 0.01), and received similar treatments compared to non-IVBCL AIS cases. Multivariate regression identified age at AIS admission, hypertension, and substance abuse as significant predictors of AIS in IVLBCL patients (all: OR > 1.0, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>While limited by database constraints and IVLBCL's rarity, this study highlights the potential link between IVLBCL and AIS. These findings not only emphasize the importance of vigilance and preventive measures in managing the health of cancer patients but also suggest potential avenues for enhancing patient care and outcomes.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.5000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01616412.2025.2554920","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: A significantly increased risk of cerebrovascular disease (CVD) is well documented among patients diagnosed with various malignancies. Cancer patients face nearly double the risk of acute ischemic stroke (AIS) compared to the general population. Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of non-Hodgkin B-cell lymphoma characterized by the proliferation of neoplastic lymphoma cells within the vasculature of organs. Occurring in <0.5 per 1,000,000 persons, it is exceptionally rare. This study investigates AIS occurrence in IVLBCL patients.
Methods: The National Inpatient Sample (NIS) was queried from the period of 2010-2019 using the International Classification of Diseases (ICD) 9th and 10th edition codes to identify patients admitted for AIS either with or without IVLBCL.
Results: We identified 44 cases of IVLBCL among 705,928 AIS patients. We found that IVLBCL patients who experienced AIS were generally older (74.5 vs. 70.15 years, p < 0.0001), had less severe strokes (0.33 vs. 0.47, p < 0.01), longer hospital stays (12.22 vs. 5.99 days, p < 0.01), and received similar treatments compared to non-IVBCL AIS cases. Multivariate regression identified age at AIS admission, hypertension, and substance abuse as significant predictors of AIS in IVLBCL patients (all: OR > 1.0, p < 0.05).
Conclusion: While limited by database constraints and IVLBCL's rarity, this study highlights the potential link between IVLBCL and AIS. These findings not only emphasize the importance of vigilance and preventive measures in managing the health of cancer patients but also suggest potential avenues for enhancing patient care and outcomes.
目的：在诊断为各种恶性肿瘤的患者中，脑血管疾病（CVD）的风险显著增加。与一般人群相比，癌症患者面临的急性缺血性中风（AIS）风险几乎是其两倍。血管内大b细胞淋巴瘤（IVLBCL）是一种罕见的侵袭性非霍奇金b细胞淋巴瘤亚型，其特征是肿瘤淋巴瘤细胞在器官血管内增殖。方法：使用国际疾病分类（ICD）第9版和第10版代码查询2010-2019年期间的全国住院患者样本（NIS），以识别患有或不患有IVLBCL的AIS患者。结果：我们在705928例AIS患者中发现44例IVLBCL。我们发现经历AIS的IVLBCL患者通常年龄较大（74.5岁vs 70.15岁，p p p 1.0, p）。结论：尽管受到数据库约束和IVLBCL罕见性的限制，本研究强调了IVLBCL与AIS之间的潜在联系。这些发现不仅强调了警惕和预防措施在管理癌症患者健康方面的重要性，而且还提出了加强患者护理和结果的潜在途径。
期刊介绍：
Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields.
The scope of the journal includes:
•Stem cell applications
•Molecular neuroscience
•Neuropharmacology
•Neuroradiology
•Neurochemistry
•Biomathematical models
•Endovascular neurosurgery
•Innovation in neurosurgery.
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