Neurological Research最新文献_第4页

The relationship between serum GDF15 levels and non-motor symptoms in Parkinson's disease. 帕金森病患者血清GDF15水平与非运动症状的关系

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-18 DOI: 10.1080/01616412.2025.2480331

Jianli Wang, Ting Geng, Xiaomei Yao, Yiming Liu

{"title":"The relationship between serum GDF15 levels and non-motor symptoms in Parkinson's disease.","authors":"Jianli Wang, Ting Geng, Xiaomei Yao, Yiming Liu","doi":"10.1080/01616412.2025.2480331","DOIUrl":"10.1080/01616412.2025.2480331","url":null,"abstract":"Objectives: The primary aim was to investigate the relationship between serum growth differentiation factor-15 (GDF15) levels and non-motor symptom (NMS) in Parkinson's disease (PD) patients. The secondary aim was to explore the diagnostic value of GDF15 for specific NMS.Methods: A total of 102 PD patients were enrolled in this study, including 47 males and 55 females. Doctors collected the clinical and demographic information of patients and detected the level of serum GDF15. Next, linear univariate and multivariate linear regression analyses were used to assess the correlation between GDF15 and NMS. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off value of GDF15 and evaluate its diagnostic value.Results: In PD patients, there was no significant difference in serum GDF15 levels between males and females (p = 0.831). Age of PD onset, pesticide use, depression, sexual dysfunction, Epworth Sleepiness Scale (ESS) and Hamilton Depression Scale (HAMD) were associated with serum GDF15. Serum GDF15 was negatively correlated with HAMD, depression and sexual dysfunction and positively correlated with ESS. Each 10 pg/ml increase in serum GDF15 levels was associated with a 4% lower risk of depression and a 5% lower risk of sexual dysfunction. Notably, serum GDF15 may be a biomarker for distinguishing depression and sexual dysfunction in PD patients.Conclusion: Elevated serum GDF15 reduced the risk of PD with depression and sexual dysfunction. Serum GDF15 may be a biomarker for distinguishing depression and sexual dysfunction in PD patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis. 与二硫化相关的免疫检查点基因CD276参与胶质母细胞瘤恶性表型和不良预后的形成。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-13 DOI: 10.1080/01616412.2025.2476506

Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui

{"title":"Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis.","authors":"Jianwei Zhuo, Jing Zhang, Yinong Xu, Meng Ji, Haitao Shen, Gang Cui","doi":"10.1080/01616412.2025.2476506","DOIUrl":"https://doi.org/10.1080/01616412.2025.2476506","url":null,"abstract":"Background: Immunotherapy has promise for glioblastoma multiforme (GBM) treatment and disulfidptosis, a form of cell death involving disintegration of the actin cytoskeleton, is a potential target. The aim of the current study was to identify genes associated with disulfidptosis-related immune checkpoints in GBM and to analyze connections with malignancy.Methods: Two expression matrices from The Cancer Genome Atlas-Genotype Tissue Expression (TCGA-GTEx) and Chinese Glioma Genome Atlas (CGGA) cyber public data were utilized to analyze differentially expressed genes (DEGs) in GBM and interaction networks for DEG-coded proteins constructed with protein-protein interaction network analysis. Functional annotation was conducted to indicate DEG function. Hub genes were identified by machine-learning, using Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine Recursive Feature Elimination (SVM-RFE). Gene expression, immune cell composition and single-cell expression were assessed via bioinformatics and in vitro assays. Finally, xenograft nude mouse models were constructed for in vivo validation.Results: 35 DEGs were found in the TCGA-GTEx and 13 in the CGGA databases and linked to immune regulation and GBM progression. The key gene CD276 was screened by bioinformatics methods. CD276 had higher expression in GBM tissues than in control and was higher expression in GBM strain than in normal astrocytes. In vitro CD276 knockdown reduced GBM cell malignancy. Furthermore, CD276 knockdown suppressed tumor growth in vivo.Conclusion: CD276 was the most significant hub gene involved in disulfidptosis and immune checkpoints in GBM. Anti-CD276 therapy may have promise for GBM treatment.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis. 探索饮食因素对颅内动脉瘤风险的影响：来自孟德尔随机化分析的见解。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-12 DOI: 10.1080/01616412.2025.2477240

Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao

{"title":"Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.","authors":"Junren Ma, Kang Zong, Yonghui Wang, Congyan Wu, Hanchen Liu, Ruyue Lin, Rui Li, Chao Zou, Qiao Zuo, Yi Xu, Jianmin Liu, Rui Zhao","doi":"10.1080/01616412.2025.2477240","DOIUrl":"https://doi.org/10.1080/01616412.2025.2477240","url":null,"abstract":"Background: While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted.Methods: In our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties, vegetarian foods, cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases. In MR analysis, we employed multiple Mendelian randomization techniques such as MR-Egger, Inverse Variance Weighted methods and rigorously controlled the false discovery rates through the Bonferroni correction across 10 dietary exposures.Results: Our analysis identified a significant association between cooked vegetables (OR: 9.939; 95% CI: 2.066 ~ 47.822; p = 0.0042) and an elevated risk of intracranial aneurysms. Besides, the initial analysis suggested a statistically significant association between the dried fruit (OR: 0.385; 95%CI: 0.159 ~ 0.935; p = 0.0350), frequency of alcohol intake (OR: 1.419; 95% CI: 1.039 ~ 1.937; p = 0.0276) and the risk of intracranial aneurysms. However, this significance was not sustained after applying the Bonferroni correction for multiple testing, indicating a need for cautious interpretation despite the initially promising findings.Conclusion: This study identified a clear causal link between cooked vegetable intake and an increased risk of intracranial aneurysm, while suggesting a potential connection between the frequency of alcohol intake and the elevated risk, although this association did not reach statistical significance after multiple testing corrections.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis. 穴位注射配合特定电磁波谱照射与针刺治疗周围性面瘫的疗效观察。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-06 DOI: 10.1080/01616412.2025.2476515

Meihua Sun, Mingli Ge, Qinglin Shen

{"title":"Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.","authors":"Meihua Sun, Mingli Ge, Qinglin Shen","doi":"10.1080/01616412.2025.2476515","DOIUrl":"https://doi.org/10.1080/01616412.2025.2476515","url":null,"abstract":"Objective: To investigate the clinical effectiveness of acupoint injection in the treatment of acute phase of peripheral facial paralysis (PFP).Methods: A total of 85 patients with PFP were randomly divided into the control group, which was treated by prednisone acetate; the thermal design power (TDP) group, which was treated with acupuncture plus specific electromagnetic spectrum irradiation; and the acupoint injection group, which was treated with acupuncture plus specific electromagnetic spectrum irradiation combined with vitamin B1 (Vit B1) and vitamin B12 (Vit B12) acupoint injection. The treatment effectiveness was evaluated by Portmann score of facial paralysis, House-Brackmann (H-B) facial nerve function grading, serum levels of IL-6, IL-1β, and TNF-α, the cure time, and total effective rate.Results: The scores of Portmann and H-B in the TDP group were significantly higher than the control group, and the acupoint injection group was higher than the TDP group after each course of treatment (p < 0.05). The time to produce a significant effectiveness was shortened in the order of the acupoint injection group > the TDP group > the control group (p < 0.05). The cure rate was higher in the acupoint injection group (100%) than the TDP group (72.41%) and control group (67.86%) (p < 0.05). The serum levels of IL-6, IL-1β and TNF-α were obviously lower in the TDP group than the control group and in the acupoint injection group were lower than the TDP group (p < 0.05).Conclusion: Acupoint injection can significantly improve the curative effect, shorten the cure time, reduce the level of serum inflammatory factors, and promote the recovery of facial nerve function in the acute stage of PFP.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The correlation between vitamin B12 serum levels and migraine: a case-control study. 维生素B12血清水平与偏头痛的相关性：一项病例对照研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/01616412.2025.2462735

Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed

{"title":"The correlation between vitamin B12 serum levels and migraine: a case-control study.","authors":"Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed","doi":"10.1080/01616412.2025.2462735","DOIUrl":"10.1080/01616412.2025.2462735","url":null,"abstract":"Objectives: Migraine represents the prevailing form of primary headache with no fully described etiology and pathophysiology. This study aimed to assess the association between vitamin B12 serum levels and both chronic and episodic migraine.Patients and methods: This study was conducted as a case-control study, including 90 migraineurs, divided into 48 with episodic migraine and 42 with chronic migraine as the case group, and 90 matched healthy participants as the control group. The serum level of vitamin B12 was measured using enzyme-linked immunosorbent assay (ELISA) for all subjects. Its association with the Migraine Disability Assessment (MIDAS) scale and migraine attack severity, measured using the Visual Analog Scale (VAS), was analyzed.Results: Migraineurs exhibited a notable reduction in serum vitamin B12 levels compared to the control group (243.97 ± 124.85 pg/ml vs. 302.69 ± 143.69 pg/ml, p = 0.014). Furthermore, chronic migraine patients had significantly lower serum vitamin B12 levels when compared to episodic migraine patients (202.7 ± 75.62 pg/ml vs. 269.17 ± 143.31 pg/ml, p = 0.026). A significant negative correlation was found between serum vitamin B12 levels and the severity of migraine attacks, as measured by the VAS (r = -0.407, p = 0.036).Conclusion: The current study highlighted that vitamin B12 deficiency is highly associated with migraine and its severity. Further interventional research is highly recommended to investigate the potential causality of this association.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"195-200"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients. 轻度多发性硬化症患者膝关节屈伸肌同心及等距强度与姿势稳定性的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1080/01616412.2025.2462734

Seval Yilmaz, Nezehat Özgül Ünlüer

{"title":"The relationship between concentric and isometric strength of knee flexor and extensor muscles and postural stability in mild stage multiple sclerosis patients.","authors":"Seval Yilmaz, Nezehat Özgül Ünlüer","doi":"10.1080/01616412.2025.2462734","DOIUrl":"10.1080/01616412.2025.2462734","url":null,"abstract":"Background: Multiple sclerosis (MS) affects muscle strength and postural stability. However, the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS is not well known. The aim of the study was to examine the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS patients.Materials and methods: The study included 21 mild-stage MS patients with an EDSS score of 4 or less and 21 healthy controls. The concentric and isometric strength of knee flexors and extensors was measured with the Biodex System 4 Dynamometer, and postural stability with the Biodex Balance System under eyes-open and eyes-closed conditions on a rigid surface.Results: Mild-stage MS patients had reduced concentric strength of knee extensors and flexors and increased postural sway compared with healthy controls (p < 0.05). Isometric strength of knee extensors and flexors in mild stage MS patients were similar to healthy controls (p > 0.05). There was a moderate positive correlation between concentric strength of knee extensors and flexors and isometric strength of knee flexors and open-eye postural stability indexes in mild stage multiple sclerosis patients (p < 0.05).Conclusions: While isometric strength of knee extensors and flexors was preserved, concentric strength of knee extensors and flexors was decreased, and postural stability was adversely affected in mild stage MS patients. The increase in the strength of the knee muscles was associated with an increase in their postural sway in mild stage MS patients.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"188-194"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD22 exacerbates brain injury in subarachnoid hemorrhage by inhibiting microglial phagocytic function. CD22通过抑制小胶质细胞吞噬功能加重蛛网膜下腔出血脑损伤。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-15 DOI: 10.1080/01616412.2025.2462731

Erliang Jin, Jing Han, Wanxi Pan, Longfei Yao, Lai Jiang, Hua Tang

{"title":"CD22 exacerbates brain injury in subarachnoid hemorrhage by inhibiting microglial phagocytic function.","authors":"Erliang Jin, Jing Han, Wanxi Pan, Longfei Yao, Lai Jiang, Hua Tang","doi":"10.1080/01616412.2025.2462731","DOIUrl":"10.1080/01616412.2025.2462731","url":null,"abstract":"Introduction: Subarachnoid hemorrhage (SAH) is a neurological emergency with a high mortality rate. The phagocytic and homeostatic functions of microglial cells play a crucial role after SAH. This study aims to investigate the mechanism of CD22-mediated abnormal microglial phagocytosis in brain injury caused by SAH.Materials and methods: BV2 microglial cells were exposed to 10 µM oxyhemoglobin for 24 hours to establish an in vitro SAH model. After CD22 knockdown, cell viability was assessed using the cell counting kit-8. The microglial phagocytic function was evaluated using pHrodo Red E.coli BioParticles and fluorescence microscopy. The expression levels of Kruppel-like factor 4 (KLF4), miR-150-3p, and CD22 were analyzed by real-time quantitative reverse transcription polymerase chain reaction and Western blot analysis. The binding relationship of KLF4 to the miR-150-3p promoter and the binding relationship of miR-150-3p to the CD22 3'UTR sequence were analyzed. Overexpression of KLF4 and inhibition of miR-150-3p in SAH cells were conducted to validate the mechanism.Results: SAH inhibited the microglial phagocytic function. CD22 was overexpressed in the SAH cell model. CD22 inhibition increased the microglial phagocytic function. miR-150-3p targeted and inhibited CD22 expression. Overexpression of miR-150-3p resulted in downregulation of CD22 and increased phagocytic function in microglial cells. KLF4 bound to the miR-150-3p promoter and promoted miR-150-3p expression. Overexpression of KLF4 reversed the inhibitory effect of miR-150-3p inhibition on phagocytic function in SAH cell model.Conclusion: KLF4 enhances the microglial phagocytic function in SAH by promoting miR-150-3p and inhibiting CD22.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"211-221"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between the dynamics of red cell distribution width to lymphocyte ratio and clinical outcomes in patients with traumatic brain injury. 外伤性脑损伤患者红细胞分布宽度与淋巴细胞比值动态变化与临床预后的关系。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1080/01616412.2025.2462732

Ehsan Alimohammadi, Elnaz Fatahi, Samira Shiri, Akram Amiri, Seyed Reza Bagheri

{"title":"The association between the dynamics of red cell distribution width to lymphocyte ratio and clinical outcomes in patients with traumatic brain injury.","authors":"Ehsan Alimohammadi, Elnaz Fatahi, Samira Shiri, Akram Amiri, Seyed Reza Bagheri","doi":"10.1080/01616412.2025.2462732","DOIUrl":"10.1080/01616412.2025.2462732","url":null,"abstract":"Background: Traumatic brain injury (TBI) is a major cause of morbidity and mortality, particularly among young individuals. This study investigates the correlation between the dynamic of Red Cell Distribution Width to Lymphocyte Ratio (RDWLR) and clinical outcomes in patients with moderate to severe TBI.Methods: A retrospective analysis was conducted on 405 consecutive patients with moderate to severe TBI admitted between July 2018 and July 2023. Clinical outcomes were assessed using the Glasgow Outcome Scale (GOS), categorized into favorable (GOS 4,5) and unfavorable outcomes (GOS 1,2,3). Data on demographics, clinical presentation, radiological findings, and laboratory tests were collected. Binary logistic regression analyzed the independent associations between variables, including changes in RDWLR over four days.Results: Among the 405 patients, 53.1% were male, with an average age of 33.21 years. ROC curve analysis identified a delta RDWLR threshold of 0.001. Of the patients, 67.1% had low delta RDWLR, while 33.8% had high delta RDWLR. Multivariate analysis showed that Glasgow Coma Scale (GCS) (OR 3.22; p < 0.001), light reflex (OR 1.87; p = 0.025), Rotterdam CT score (OR 2.33; p = 0.025), and change in RDWLR (OR 1.68; p = 0.031) were significantly associated with poor clinical outcomes.Conclusions: These findings suggest that delta RDWLR has potential as as a prognostic indicator of poor clinical outcomes in patients with moderate to severe traumatic brain injury (TBI), providing a cost-effective biomarker for clinical prognosis. However, further validation through prospective multicenter studies is needed.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"172-177"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative study of cognitive function and reaction time in obese and non-obese adults. 肥胖和非肥胖成人认知功能和反应时间的比较研究。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/01616412.2025.2462739

Hacı Ömer Yılmaz, Kezban Şahin, Hilal Ayvaz

{"title":"A comparative study of cognitive function and reaction time in obese and non-obese adults.","authors":"Hacı Ömer Yılmaz, Kezban Şahin, Hilal Ayvaz","doi":"10.1080/01616412.2025.2462739","DOIUrl":"10.1080/01616412.2025.2462739","url":null,"abstract":"Objective: Obesity may negatively affect the physical health and cognitive functions of individuals and delay their reaction time to stimuli. However, the association among obesity, cognitive functions, and reaction times is yet to be fully elucidated. The aim of this study was to assess the effect of obesity on cognitive functions and visual and auditory reaction times in adults.Methods: Data of 100 participants (50 obese and 50 normal) were analyzed in the study. Anthropometric parameters and 24-h dietary recall data were recorded. The Montreal Cognitive Assessment (MoCA) was used to evaluate the cognitive functions, Simple Reaction Time Task (SRTT)-Visual and SRTT-Auditory were used to assess visual and auditory reaction times of the participants, respectively.Results: The mean MoCA score of the obese was significantly lower than normal (17.46 and 25.22, respectively; p < 0.001). In addition, the mean auditory (p < 0.001) and visual (p < 0.05) reaction times of obese were significantly longer than normal. Similarly, this condition was also observed for the fastest and lowest values of auditory and visual reaction times. Additionally, obesity caused a decrease in the MoCA score (β = -0.762; p < 0.001) and delayed visual (β = 0.423; p < 0.001) and auditory (β = 0.590; p < 0.001) reactions. The negative effect of obesity was maintained after controlling for potential factors (MoCA, β = -0.594; p < 0.001; SRTT-Auditory, β = 0.409; p < 0.01; SRTT-Visual, β = 0.330; p < 0.05).Conclusion: Obese participants showed worse cognitive, auditory and visual performance. Additional research will be necessary in the future to shed light on the fundamental mechanisms involved.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"201-210"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of tranexamic acid against hydrogen peroxide-induced cytotoxicity on human neuroblastoma SH-SY5Y cells. 氨甲环酸抗过氧化氢诱导的人神经母细胞瘤SH-SY5Y细胞毒性的神经保护作用。

IF 1.7 4区医学

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1080/01616412.2025.2462030

Ali Niapour, Yavar Mohebi, Hossein Ghalehnoei

{"title":"Neuroprotective effects of tranexamic acid against hydrogen peroxide-induced cytotoxicity on human neuroblastoma SH-SY5Y cells.","authors":"Ali Niapour, Yavar Mohebi, Hossein Ghalehnoei","doi":"10.1080/01616412.2025.2462030","DOIUrl":"10.1080/01616412.2025.2462030","url":null,"abstract":"Introduction: Tranexamic acid (TA) is an anticoagulant drug that is used worldwide. However, the adverse effects of TA may insult the nervous system. This study aimed to investigate the dual effects of TA on SH-SY5Y cells, including its detrimental and neuroprotective effects.Methods: SH-SY5Y cells were treated with various concentrations of TA and exposed to H2O2 for 24 hours. The neuroprotective effects of TA were evaluated in H2O2-challenged cells. To assess the neuroprotective effects of TA, SH-SY5Y cells were pretreated with TA for 12 hours and then exposed to H2O2 for 24 hours. Cell viability was assessed using the MTT assay. Flow cytometry was used to evaluate cellular apoptosis. The expression of Bax, Bcl-2, and Caspase-3 genes was analyzed by real-time PCR. Additionally, Akt phosphorylation was evaluated using western blotting.Results: At high concentrations, TA reduced cell viability and induced apoptosis by up-regulating BAX and Caspase-3 gene expression and down-regulating BCL-2 transcript. Furthermore, Akt phosphorylation was reduced following TA treatment. TA exhibited protective effects against H2O2-induced cell stress by down-regulating Bax and Caspase-3 gene expression, up-regulating Bcl-2 expression, and increasing the p-AKT/AKT ratio.Conclusion: Our findings demonstrated that TA exerts its neuroprotective effect at lower concentrations, but induces apoptosis in SH-SY5Y cells at high concentrations.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"163-171"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0