Neurological Research最新文献

{"title":"Endovascular thrombectomy versus medical management for basilar artery occlusion stroke with mild neurological deficit - results from the BASILAR registry.","authors":"Zhenyu Kong, Liang Ye, Hong Wang, Bo Yang, Jianhui Xu, Keping Qiao, Tiantian Fan, Guanxiao Ding, Zihan Qiu, Zeng Zhao, Xiangdong Xie, Shunfu Jiang, Hongmei Xu, Jeffrey L Saver, Götz Thomalla, Qingwu Yang, Hongfei Sang, Thanh N Nguyen, Zhongming Qiu, Jun Luo, Mingchao Li, Yong Liang","doi":"10.1080/01616412.2025.2559304","DOIUrl":"https://doi.org/10.1080/01616412.2025.2559304","url":null,"abstract":"<p><strong>Background: </strong>Endovascular thrombectomy (EVT) benefits basilar artery occlusion (BAO) patients with moderate-to-severe deficits, but its role in patients with mild neurological deficits (NIHSS ≤10) remains controversial. This study aimed to compare clinical and safety outcomes of EVT plus medical management (MM) versus MM alone in acute BAO patients with mild deficits.</p><p><strong>Methods: </strong>Ninety-eight patients from the BASILAR registry met the criteria and were included in this analysis (EVT: <i>n</i> = 70; MM: <i>n</i> = 28). Inverse probability weighting (IPW) adjusted for baseline imbalances. A systematic review and meta-analysis of seven studies was conducted to synthesize existing evidence. Interventions included EVT plus MM versus MM alone. The primary outcome was 90-day functional independence (modified Rankin Scale [mRS] 0-2); secondary outcomes included excellent (mRS 0-1) and favorable (mRS 0-3) outcomes, mortality, and symptomatic intracranial hemorrhage (sICH).</p><p><strong>Results: </strong>In the BASILAR cohort, EVT was associated with higher likelihood of functional independence (IPW-adjusted odds ratio [aOR] 8.46, 95% CI 2.29-31.17; <i>p</i> < 0.001) versus MM, with no increased risk of sICH (1.3% vs. 0%) and death (aOR 0.35, 95% CI 0.07-1.63, <i>p</i> = 0.18). Meta-analysis confirmed higher association of EVT with higher odds of functional independence (pooled aOR 1.78, 95% CI 1.00-3.18; <i>p</i> = 0.05) and excellent outcomes (aOR 3.98, 95% CI 1.32-11.95; <i>p</i> = 0.01), without elevated risk of sICH and death.</p><p><strong>Conclusion: </strong>In acute BAO patients with mild neurological deficits, EVT was associated with improved functional independence without increased risks of mortality or sICH. These findings advocate for reconsidering the role of EVT role in this population, pending validation through randomized trials.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon guide catheters for endovascular thrombectomy: a systematic review and meta-analysis of randomized controlled trials.","authors":"Hongyu Ma, Yu Gao, Manyue Ge, Guojie Chen, Xiaoxi Zhang, Hongye Xu, Zifu Li, Yu Zhou, Pengfei Yang, Jianmin Liu","doi":"10.1080/01616412.2025.2556246","DOIUrl":"https://doi.org/10.1080/01616412.2025.2556246","url":null,"abstract":"<p><strong>Objective: </strong>Whether temporary blood flow arrest using balloon guide catheters (BGC) facilitates endovascular thrombectomy for acute ischemic stroke due to large-vessel occlusion (AIS-LVO) remains controversial. We conducted a meta-analysis of randomized controlled trials to evaluate the efficacy and safety of BGC utilization during thrombectomy for AIS-LVO.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane Library, Elsevier, and Web of Science databases were searched from inception to 1 June 2025, for studies evaluating BGC in AIS-LVO patients undergoing thrombectomy. Eligibility screening and data extraction were independently conducted by two investigators following PRISMA guidelines. The primary outcome was 90-day functional independence, defined as a modified Rankin scale (mRS) score of 0-2.</p><p><strong>Results: </strong>Of 431 articles identified, two randomized trials involving 460 patients met the inclusion criteria, in which 230 patients received thrombectomy with blood flow arrest using BGC, and 230 patients without flow arrest. Compared with the nonflow arrest group, the flow arrest group showed no significant difference in 90-day functional independence (34.78% vs. 37.83%; odds ratio[OR], 0.88 [95% confidence interval [CI], 0.6-1.28]; <i>p</i> = 0.50), rates of eTICI 2c-3 at the end of the procedure (77.39% vs. 78.26%; OR, 0.95 [95% CI, 0.61-1.48]; <i>p</i> = 0.83), or emboli to new territory (3.04% vs. 6.09%; OR, 0.4 [95% CI, 0.04-3.58]; <i>p</i> = 0.41). Safety outcomes did not differ significantly between groups.</p><p><strong>Conclusion: </strong>Temporary blood flow arrest with BGC did not significantly improve the functional independence in patients receiving thrombectomy for AIS-LVO. This technique remains a subject for future studies to confirm its efficacy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A-to-I editing of miR-579-3p exacerbates neonatal hypoxic-ischemic brain injury via regulation of ABCD3-dependent lipid metabolism in astrocytes.","authors":"KeXin Wang, Fang Wang","doi":"10.1080/01616412.2025.2559296","DOIUrl":"https://doi.org/10.1080/01616412.2025.2559296","url":null,"abstract":"<p><strong>Background: </strong>Neonatal hypoxic-ischemic brain injury (HIBD) often results in high morbidity and mortality, with a complicated pathogenesis. This investigation is focused on uncovering the role and mechanism of edited miR-579-3p in HIBD.</p><p><strong>Methods: </strong>Western blot analysis and RT-qPCR were employed to examine the expression of protein and mRNA. To assess cell proliferation and apoptosis, MTT, EdU, and flow cytometry assays were utilized. Commercially available kits were obtained to detect ROS level. The VLCFA concentration was determined through ELISA. A dual-luciferase reporter assay verified the miRNA targets.</p><p><strong>Results: </strong>Increased editing level of miR-579-3p at position 4 induced by ADAR2 enzyme was observed in HIE patients, which was related to HIE clinical grade. Functionally, wild-type and edited miR-579-3p showed opposite effect on astrocytes activity. Specifically, ed-miR-579-3p restrained the cell viability of astrocytes with OGD/R treatment and accelerates apoptosis. Mechanically, A-to-I RNA editing alters the targets of miR-579-3p. And ed-miR-579-3p obtains novel target ABCD3 and loses TRAF6. TRAF6 overexpression restrained the cell viability of astrocytes with OGD/R treatment, which was not affected by edited miR-579-3p. Further, edited miR-579-3p restrained the cell viability of astrocytes with OGD/R treatment by impairing ABCD3-mediated β-oxidation of VLCFA. In vivo experiment also demonstrated that edited miR-579-3p aggravated brain damage in HIBD by impairing ABCD3-mediated astrocytes lipid metabolism.</p><p><strong>Conclusion: </strong>Edited miR-579-3p aggravates brain damage in HIBD by impairing ABCD3-mediated VLCFA β-oxidation of astrocytes.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with prolonged intensive unit stay following mechanical thrombectomy for acute ischemic stroke.","authors":"Saqib A Chaudhry, Aysha Jadran, Hamza Khan, Rauf Chaudhry, Duaa Chaudhry, Zarina Laleka, Sairah Bashir, Pouya Tahsili Fahadan, Laith Altaweel, Ashfaq Shuaib, Adnan I Qureshi","doi":"10.1080/01616412.2025.2559308","DOIUrl":"https://doi.org/10.1080/01616412.2025.2559308","url":null,"abstract":"<p><strong>Objective and background: </strong>The aim of the study was to investigate factors affecting the length of stay (LoS) in the intensive care unit (ICU) following mechanical thrombectomy (MT) for acute ischemic stroke.</p><p><strong>Methods: </strong>We conducted a retrospective analysis using data from a prospective stroke registry at a comprehensive stroke center between January 2019 and June 2024. ICU stay for more than 48 hours was defined as prolonged ICU stay.</p><p><strong>Results: </strong>Out of 808 patients, 39.2% (<i>n</i> = 317) required a prolonged ICU LoS. Prolonged ICU stay was more likely to have a baseline National Institutes of Health Stroke Scale NIHSS ≥ 15, higher mean HbA1c levels, posterior circulation stroke, intubation for the procedure, symptomatic intracerebral hemorrhage, in-patient mortality and ICU complications including pneumonia, deep vein thrombosis, pulmonary embolism, urinary tract infection (all <i>p</i> value < 0.05). Patients receiving thrombolysis prior to thrombectomy were less likely to have a prolonged LoS (<i>p</i> = 0.0025). Independent predictors for prolonged ICU LoS included baseline NIHSS ≥ 15 (odds ratio [OR] 1.83, <i>p</i> = 0.0004), intubation prior to the procedure (OR 2.20, <i>p</i> < 0.0001), receiving IV thrombolysis (OR 0.66, <i>p</i> = 0.0144), recanalization (OR 0.48, <i>p</i> = 0.0085, composite ICU complications (OR 2.66, <i>p</i> < 0.0001), and symptomatic intracranial hemorrhage (sICH) (OR 3.38, <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Almost one-third of the acute ischemic stroke patients required a prolonged LoS following MT. A better understanding of the factors associated with prolonged ICU stay may assist in appropriate allocation of resources.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of interhospital transfer on patients undergoing endovascular thrombectomy for acute ischemic stroke from a comprehensive stroke center.","authors":"Saqib A Chaudhry, Aysha Jadran, Zarina Laleka, Mohammad Rauf Chaudhry, Heela Afzal, Jing Wang, Zelalem Bahiru, Fang Yun, Pouya Tahsili Fahadan, Laith Altaweel, Adnan I Qureshi, Ashfaq Shuaib","doi":"10.1080/01616412.2025.2560070","DOIUrl":"https://doi.org/10.1080/01616412.2025.2560070","url":null,"abstract":"<p><strong>Background: </strong>Patients with acute stroke frequently require transfer to a comprehensive stroke center (CSC) for endovascular thrombectomy (EVT). We studied the impact of the transfer on functional outcomes for acute ischemic stroke caused by large vessel occlusion (LVO).</p><p><strong>Methods: </strong>We conducted a retrospective analysis using data from a prospective stroke registry on patients who underwent EVT for LVO between January 2019 and June 2024 at a CSC.</p><p><strong>Results: </strong>Three hundred and seventy-six of seven hundred seventy three patients were transferred to the CSC and were significantly younger (67.4 ± 15.2 vs. 71.7 ± 15.0, p-value = 0.0002). No significant differences were observed in baseline characteristics, including gender, admission National Institutes of Health Stroke Scale (NIHSS), and the rate of intravenous thrombolysis between the two groups. The time from symptom onset to groin puncture was significantly longer for the transfer group (690.1 min vs. 486.0 min, <i>p</i> < 0.0001). The time of symptom onset to reperfusion time was also longer for the transfer group (713.3 min vs. 521.8 min, <i>p</i> < 0.0001). The groin puncture to reperfusion time (39.0 min vs. 36.8 min, <i>p</i> = 0.2183), and door-in to reperfusion time (312 min vs. 223.3 min, <i>p</i> = 0.0731), were comparable between the two cohorts. Likewise, the rates of successful reperfusion TICI grade ≥2B, symptomatic intracranial hemorrhage (sICH), discharge to home, and in-hospital mortality were similar between the two groups (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Despite significantly longer time intervals from symptom onset to the initiation of mechanical thrombectomy in transfer patients, there were no adverse consequences on prognosis.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific behavioral impairments and neuronal alterations in Wistar rats following repeated sevoflurane exposure during developmental stages.","authors":"Mahdieh Nasiri, Amir Barzegar Behrooz, Soheila Adeli, Nitesh Sanghai, Seyed Khalil Pestehei, Javad Fahanik Babaei","doi":"10.1080/01616412.2025.2559303","DOIUrl":"https://doi.org/10.1080/01616412.2025.2559303","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the effects of repeated exposure to sevoflurane as an anesthetic agent during various developmental stages, namely neonatal, preadolescent, and adult, on behavioral, synaptic, and neuronal plasticity in male and female Wistar rats.</p><p><strong>Methods: </strong>Rats were exposed to sevoflurane during three developmental stages: neonatal (PN7), pre-adolescence (PN28), and adulthood (PN90). Behavioral performance was evaluated with the Morris Water Maze. Electrophysiological analyses measured population spike (PS) amplitude, slope, and long-term potentiation (LTP) to assess synaptic plasticity. Short-term plasticity was additionally studied using paired-pulse facilitation tests.</p><p><strong>Results: </strong>Repeated neonatal exposure to sevoflurane caused significant impairments in spatial learning and memory, whereas exposures during pre-adolescence and adulthood had minimal effects. Electrophysiological data revealed a reduction in PS amplitude and slope, as well as impaired LTP, particularly in neonatal and pre-adolescent groups, with more severe deficits observed in males. Paired-pulse facilitation indicated greater short-term plasticity deficits in males at shorter intervals.</p><p><strong>Discussion: </strong>The findings of this study highlight the increased vulnerability of the developing brain, particularly during the neonatal period, to the adverse effects of repeated exposure to sevoflurane, resulting in long-lasting impairments in synaptic function and behavior. The results emphasize the importance of caution when administering sevoflurane to young children and suggest that early-life exposure may have lasting effects on cognitive and synaptic health.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of combined monitoring of serum S100A12 and optic nerve sheath diameter in patients with traumatic intracranial hematoma: a single-center prospective observational study.","authors":"Yajing Zhao, Rui Qin","doi":"10.1080/01616412.2025.2556247","DOIUrl":"https://doi.org/10.1080/01616412.2025.2556247","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prognostic significance of concurrent monitoring of serum S100 calcium-binding protein A12 (S100A12) and optic nerve sheath diameter (ONSD) in patients with traumatic intracranial hematoma.</p><p><strong>Methods: </strong>This prospective observational study included 198 patients with traumatic intracranial hematoma from Xingtai Central Hospital (February 2022-June 2024). Serum S100A12 and ONSD were measured at admission and postoperatively, and patients received minimally invasive therapy. Patients were categorized into good prognosis (<i>n</i> = 150) and poor prognosis (<i>n</i> = 48) groups based on their outcomes. Levels of S100A12 and ONSD were compared between groups. ROC analysis evaluated prognostic utility, Pearson correlation assessed the relationship between S100A12 and ONSD, and multivariate logistic regression identified risk factors.</p><p><strong>Results: </strong>Pre- and post-treatment, both serum S100A12 and ONSD were higher in the poor prognosis group than in the good prognosis group (all <i>p</i> < 0.05). ROC analysis showed an AUC of 0.889 for combined S100A12 and ONSD in predicting prognosis. Pearson correlation revealed a strong positive correlation between S100A12 and ONSD in the poor prognosis group (<i>r</i> = 0.708, <i>p</i> < 0.001). Multivariate logistic regression indicated that a higher Glasgow Coma Scale (GCS) score at admission was protective, while larger preoperative hematoma volume and elevated S100A12 and ONSD were risk factors for poor prognosis (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Serum S100A12 and ONSD may serve as potential targets for assessing prognosis in patients with traumatic intracranial hematoma undergoing minimally invasive treatment.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroxisome proliferator-activated receptor pathway and key genes in cerebellar dysfunction induced by chronic intermittent alcohol exposure: a transcriptomic study.","authors":"Yifan Zheng, Guangtao Sun, Shuang Wei, Lingyi Kong, Jin Guo, Wei Pan, Xiaofeng Zhu, Xunzhong Qi","doi":"10.1080/01616412.2025.2556244","DOIUrl":"https://doi.org/10.1080/01616412.2025.2556244","url":null,"abstract":"<p><strong>Background: </strong>We conducted a transcriptomic analysis to examine cerebellar transcriptional changes in a mouse model of chronic intermittent alcohol exposure.</p><p><strong>Methods: </strong>We established a mouse model of chronic intermittent alcohol exposure and conducted a cerebellar transcriptomic analysis. After identifying differentially expressed genes, we analyzed pathway enrichment using the Kyoto Encyclopedia of Genes and Genomes and Gene Ontology. We subsequently constructed a protein - protein interaction network and screened for key genes whose expression levels were validated by real-time quantitative reverse transcription polymerase chain reaction.</p><p><strong>Results: </strong>We identified 212 differentially expressed genes. The peroxisome proliferator-activated receptor (PPAR) pathway was the pathway with the most significant differential expression in the model of chronic intermittent alcohol exposure. Bloc1s6, Gsk3b, Ppard, and Napb were identified as key target genes. The PPAR pathway and these four target genes may be involved in the mechanisms underlying cerebellar dysfunction induced by chronic alcohol exposure and may also contribute to the development of increased alcohol preference.</p><p><strong>Conclusion: </strong>The PPAR pathway and four target genes (Bloc1s6, Gsk3b, Ppard, and Napb) may contribute to cerebellar dysfunction and increased alcohol preference induced by chronic alcohol exposure. These findings could help identify potential therapeutic targets for chronic alcohol exposure and alcohol preference and support further investigation into the underlying mechanisms involved.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of inpatient rehabilitation on self-care and functional activities in acute ischemic stroke patients who underwent thrombectomy.","authors":"Syed A Gillani, Mohammad Maan Al-Salihi, Moeez Ahmed, Ibrahim A Bhatti, Rami Fakih, Martin Ngo, Sarah Reid, Brandi R French, Camilo R Gomez, Adnan I Qureshi","doi":"10.1080/01616412.2025.2556252","DOIUrl":"https://doi.org/10.1080/01616412.2025.2556252","url":null,"abstract":"<p><strong>Background: </strong>The benefits of rehabilitation in acute ischemic stroke patients following thrombectomy remain underexplored. We assessed which activities of daily living (ADLs) show the greatest improvement after goal-directed therapy in an inpatient rehabilitation setting.</p><p><strong>Methods: </strong>We retrospectively analyzed pre- and post-rehabilitation functional assessments in 40 acute ischemic stroke patients treated with mechanical thrombectomy. All patients received goal-directed therapy at a rehabilitation facility. Activities were grouped into two domains: (1) self-care (eating, oral hygiene, toileting hygiene, showering/bathing, dressing) and (2) functional mobility (footwear management, rolling, sit-to-lying, lying-to-sitting, sit-to-stand). Mean percent changes were calculated for each activity.</p><p><strong>Results: </strong>Patients had a mean rehabilitation stay of 18 ± 9 days. In the self-care domain, the greatest relative improvements were observed in showering/bathing (44% ± 17%), upper body dressing (39% ± 19%), and toileting hygiene (39% ± 29%). In the mobility domain, the sit-to-lying activity showed the highest improvement (44% ± 20%). All measured activities demonstrated functional gains post-rehabilitation.</p><p><strong>Conclusions: </strong>Goal-directed inpatient rehabilitation was associated with substantial improvements in both self-care and functional mobility following thrombectomy. The most notable gains were in showering/bathing and sit-to-lying transitions. These findings demonstrate that structured inpatient rehabilitation is associated with measurable improvements in functional recovery in stroke patients post-thrombectomy.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture promotes myelin repair in the corpus callosum region of cerebral ischemic rats by modulating microglia activation and polarization.","authors":"Wei Wang, Cuicui Chan, Xiuxiu Wang, Feng Wu","doi":"10.1080/01616412.2025.2559306","DOIUrl":"https://doi.org/10.1080/01616412.2025.2559306","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke can damage the cerebral white matter, resulting in myelin loss and neurological deficits. Moreover, microglial activation plays an important role in ischemic stroke; therefore, inhibiting microglial activation has become an effective therapeutic target for ischemic stroke.</p><p><strong>Objective: </strong>This study aimed to investigate the effects of electroacupuncture (EA) on microglial activation and polarization, and the role of oligodendrocyte genesis in myelin reformation after ischemic stroke.</p><p><strong>Methods: </strong>A rat model of permanent middle cerebral artery occlusion (p-MCAO) was established and treated with EA. The reparative effect of EA on corpus callosum (CC) injury in p-MCAO rats was evaluated using a nesting assay, Luxol fast blue staining, immunofluorescence staining, and Western blot. Additionally, quantitative real-time polymerase chain reaction was employed to measure inflammatory factors IL-1β and IL-10 expression levels.</p><p><strong>Results: </strong>The results showed that p-MCAO rats exhibited significantly impaired nesting ability, severe myelin loss in the CC region, reduced Olig2 protein expression, activated microglia, and predominately M1-type microglial polarization. EA treatment improved nesting behavior, mitigated myelin loss, enhanced Olig2 expression, suppressed excessive microglial activation, downregulated IL-1β, and upregulated IL-10 expression levels.</p><p><strong>Conclusions: </strong>These findings indicate that EA facilitates myelin repair in ischemic cerebral white matter by suppressing M1 microglial polarization, inducing an M2 phenotypic shift, modulating inflammatory responses, and enhancing oligodendrocyte regeneration.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}