Prognostic value of combined monitoring of serum S100A12 and optic nerve sheath diameter in patients with traumatic intracranial hematoma: a single-center prospective observational study.

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-09-09 DOI:10.1080/01616412.2025.2556247

Yajing Zhao, Rui Qin

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引用次数: 0

Abstract

Objective: To investigate the prognostic significance of concurrent monitoring of serum S100 calcium-binding protein A12 (S100A12) and optic nerve sheath diameter (ONSD) in patients with traumatic intracranial hematoma.

Methods: This prospective observational study included 198 patients with traumatic intracranial hematoma from Xingtai Central Hospital (February 2022-June 2024). Serum S100A12 and ONSD were measured at admission and postoperatively, and patients received minimally invasive therapy. Patients were categorized into good prognosis (n = 150) and poor prognosis (n = 48) groups based on their outcomes. Levels of S100A12 and ONSD were compared between groups. ROC analysis evaluated prognostic utility, Pearson correlation assessed the relationship between S100A12 and ONSD, and multivariate logistic regression identified risk factors.

Results: Pre- and post-treatment, both serum S100A12 and ONSD were higher in the poor prognosis group than in the good prognosis group (all p < 0.05). ROC analysis showed an AUC of 0.889 for combined S100A12 and ONSD in predicting prognosis. Pearson correlation revealed a strong positive correlation between S100A12 and ONSD in the poor prognosis group (r = 0.708, p < 0.001). Multivariate logistic regression indicated that a higher Glasgow Coma Scale (GCS) score at admission was protective, while larger preoperative hematoma volume and elevated S100A12 and ONSD were risk factors for poor prognosis (all p < 0.05).

Conclusion: Serum S100A12 and ONSD may serve as potential targets for assessing prognosis in patients with traumatic intracranial hematoma undergoing minimally invasive treatment.

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血清S100A12与视神经鞘直径联合监测对外伤性颅内血肿患者预后价值的单中心前瞻性观察研究

目的：探讨同时监测血清S100钙结合蛋白A12 （S100A12）和视神经鞘直径（ONSD）对外伤性颅内血肿患者预后的意义。方法：本前瞻性观察研究纳入邢台市中心医院（2022年2月- 2024年6月）198例外伤性颅内血肿患者。入院时和术后测定血清S100A12和ONSD，患者接受微创治疗。根据预后情况将患者分为预后良好组（n = 150）和预后不良组（n = 48）。比较各组间S100A12和ONSD水平。ROC分析评估预后效用，Pearson相关性评估S100A12与ONSD之间的关系，多因素logistic回归确定危险因素。结果：治疗前后，预后不良组血清S100A12和ONSD均高于预后良好组（pr均为0.708,p p）。结论：血清S100A12和ONSD可作为创伤性颅内血肿微创治疗患者预后评估的潜在指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.