抗癫痫药物模式和癫痫患者抑郁的预测因素。

IF 1.5 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-10-07 DOI:10.1080/01616412.2025.2571953

Ogunjimi Luqman, Ogunjimi Olabisi, Alabi Akinyinka, Aderinola Aderonke, Murtala Akanji, Oyenuga Ibironke, Kasumu Emmanuel, Alli Khadijat, Fagbemi Ayotomiwa, Akindolani Precious, Akinbodu Shittabey, Ottun Kofoworola, Adeyemo Stella, Johnson Deborah, Oluseyije Oluwatobiloba, Kasali Adeola, Osalusi Bamidele, Fehintola Fatai

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引用次数: 0

摘要

方法：本横断面研究招募尼日利亚西南部选定三级医院门诊就诊的940名PWE，临床确诊并有脑电图（EEG）支持，年龄≥15岁，无心因性非癫痫发作史。采用Zung抑郁自评评分（ZSRDS）评估抑郁程度，采用利物浦不良事件量表（LAEP）评估ASM的不良反应。结果：抑郁症患病率为44.5%。在多变量logistic回归中，抑郁的独立预测因素包括年龄较小（OR 0.94, p = 0.032）、LAEP平均评分较低（OR 0.90, p = 0.001）和ASM持续时间p。结论：虽然PWE中抑郁普遍存在，但不良事件、未使用ASM和使用ASM持续时间是抑郁的预测因素。卫生保健提供者应努力预防不良事件，并通过适当的药物治疗干预实现早期癫痫发作控制。

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Pattern of anti-seizure medications and predictors of depression in people with epilepsy.

Method: This cross-sectional study recruited 940 PWE attending outpatient clinics of selected tertiary hospitals in southwestern Nigeria, with diagnosis confirmed clinically and supported by electroencephalography (EEG), aged ≥15 years, with no history of psychogenic non-epileptic seizures. Zung Self-Rating Depression Score (ZSRDS) was used to assess depression, and Liverpool Adverse Event Profile (LAEP) was used to assess the adverse effects of ASM.

Results: The prevalence of depression was 44.5%. In multivariable logistic regression, independent predictors of depression included younger age (OR 0.94, p < 0.001), higher age of seizure onset (OR 1.09, p < 0.05), seizure duration < 2 years (OR 1.76, p = 0.032), lower mean LAEP score (OR 0.90, p < 0.001), not being on an ASM (OR 2.12, p = 0.001), and ASM duration < 2 years (OR 4.15, p < 0.001).

Conclusion: While depression is prevalent among PWE, adverse events, non-use of ASM, and duration of ASM use were among the predictors of depression. Health care providers should work towards preventing adverse events and achieving early seizure control with appropriate pharmacotherapeutic intervention.

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.