Relationship between white matter hyperintensity and atherogenic index of plasma in migraine.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-05-10 DOI:10.1080/01616412.2025.2502784

Gulhan Sarıcam, Fahrettin Ege, Memet Aslanyavrusu

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引用次数: 0

Abstract

Objective: White matter hyperintensities (WMH) are more commonly observed in patients with migraine compared to the general population; however, their pathophysiology remains incompletely understood. This study aims to investigate the relationship between the atherogenic index of plasma (AIP), a vascular risk marker, and WMH in patients with migraine.

Methods: This study included 274 patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-III). The relationship between WMH and AIP in migraine patients was validated by Two-State Logistic Regression Analysis, and the cubic spline curve was used to determine linearity.

Results: The mean age of the patients with migraine was 36.26 ± 8.37 years and 82.8% (n = 227) were female. The the prevalence of aura (p = 0.028), age (p = 0.001) and mean disease duration (p < 0.001, t=-4.257) were significantly higher in migraine patients with WMH than those without WMH. AIP (p < 0.001, t=-6.667), triglyceride (TG) (p < 0.001, t=-5.736) and body mass index (BMI) (p = 0.020, t=-2.344) were significantly higher in patients with WMH compared to those without WMH. A two-state regression analysis demonstrated a linear relationship between increased AIP (OR:7.101, 95% CI:3.417-14.174), TG (OR: 1.016, 95% CI: 1.005-2.023) and WHM in patients with migraine.

Conclusion: In our study, we found positive correlation between WMH and AIP values in patients with migraine, and showed that AIP values were a statistically significant discriminator of WMH. Our results suggest that the AIP can be used as a cost-effective and significant marker for determining WMH in patients with migraine.

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偏头痛患者血浆白质高密度与动脉粥样硬化指数的关系。

目的：与一般人群相比，偏头痛患者更常观察到白质高强度（WMH）；然而，其病理生理机制尚不完全清楚。本研究旨在探讨偏头痛患者血浆动脉粥样硬化指数（AIP）与WMH之间的关系。方法：本研究纳入274例根据国际头痛疾病分类（ICHD-III）诊断为偏头痛的患者。采用双状态Logistic回归分析验证偏头痛患者WMH与AIP之间的关系，并采用三次样条曲线确定线性关系。结果：偏头痛患者平均年龄36.26±8.37岁，女性占82.8% （n = 227）。有WMH偏头痛患者的先兆患病率（p = 0.028）、年龄（p = 0.001）和平均病程（p =-4.257）均显著高于无WMH偏头痛患者。WMH患者AIP （p t=-6.667）、甘油三酯（TG）（p t=-5.736）和体重指数（BMI）（p = 0.020, t=-2.344）显著高于无WMH患者。双状态回归分析显示，偏头痛患者AIP （OR:7.101, 95% CI:3.417-14.174）、TG （OR: 1.016, 95% CI: 1.005-2.023）和WHM升高呈线性关系。结论：在我们的研究中，我们发现偏头痛患者的WMH与AIP值呈正相关，并且AIP值是WMH的一个有统计学意义的判别指标。我们的研究结果表明，AIP可以作为一种具有成本效益和显著性的偏头痛患者WMH测定指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.