{"title":"偏头痛患者血浆白质高密度与动脉粥样硬化指数的关系。","authors":"Gulhan Sarıcam, Fahrettin Ege, Memet Aslanyavrusu","doi":"10.1080/01616412.2025.2502784","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>White matter hyperintensities (WMH) are more commonly observed in patients with migraine compared to the general population; however, their pathophysiology remains incompletely understood. This study aims to investigate the relationship between the atherogenic index of plasma (AIP), a vascular risk marker, and WMH in patients with migraine.</p><p><strong>Methods: </strong>This study included 274 patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-III). The relationship between WMH and AIP in migraine patients was validated by Two-State Logistic Regression Analysis, and the cubic spline curve was used to determine linearity.</p><p><strong>Results: </strong>The mean age of the patients with migraine was 36.26 ± 8.37 years and 82.8% (<i>n</i> = 227) were female. The the prevalence of aura (<i>p</i> = 0.028), age (<i>p</i> = 0.001) and mean disease duration (<i>p</i> < 0.001, <i>t</i>=-4.257) were significantly higher in migraine patients with WMH than those without WMH. AIP (<i>p</i> < 0.001, <i>t</i>=-6.667), triglyceride (TG) (<i>p</i> < 0.001, <i>t</i>=-5.736) and body mass index (BMI) (<i>p</i> = 0.020, <i>t</i>=-2.344) were significantly higher in patients with WMH compared to those without WMH. A two-state regression analysis demonstrated a linear relationship between increased AIP (OR:7.101, 95% CI:3.417-14.174), TG (OR: 1.016, 95% CI: 1.005-2.023) and WHM in patients with migraine.</p><p><strong>Conclusion: </strong>In our study, we found positive correlation between WMH and AIP values in patients with migraine, and showed that AIP values were a statistically significant discriminator of WMH. Our results suggest that the AIP can be used as a cost-effective and significant marker for determining WMH in patients with migraine.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between white matter hyperintensity and atherogenic index of plasma in migraine.\",\"authors\":\"Gulhan Sarıcam, Fahrettin Ege, Memet Aslanyavrusu\",\"doi\":\"10.1080/01616412.2025.2502784\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>White matter hyperintensities (WMH) are more commonly observed in patients with migraine compared to the general population; however, their pathophysiology remains incompletely understood. This study aims to investigate the relationship between the atherogenic index of plasma (AIP), a vascular risk marker, and WMH in patients with migraine.</p><p><strong>Methods: </strong>This study included 274 patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-III). The relationship between WMH and AIP in migraine patients was validated by Two-State Logistic Regression Analysis, and the cubic spline curve was used to determine linearity.</p><p><strong>Results: </strong>The mean age of the patients with migraine was 36.26 ± 8.37 years and 82.8% (<i>n</i> = 227) were female. The the prevalence of aura (<i>p</i> = 0.028), age (<i>p</i> = 0.001) and mean disease duration (<i>p</i> < 0.001, <i>t</i>=-4.257) were significantly higher in migraine patients with WMH than those without WMH. AIP (<i>p</i> < 0.001, <i>t</i>=-6.667), triglyceride (TG) (<i>p</i> < 0.001, <i>t</i>=-5.736) and body mass index (BMI) (<i>p</i> = 0.020, <i>t</i>=-2.344) were significantly higher in patients with WMH compared to those without WMH. A two-state regression analysis demonstrated a linear relationship between increased AIP (OR:7.101, 95% CI:3.417-14.174), TG (OR: 1.016, 95% CI: 1.005-2.023) and WHM in patients with migraine.</p><p><strong>Conclusion: </strong>In our study, we found positive correlation between WMH and AIP values in patients with migraine, and showed that AIP values were a statistically significant discriminator of WMH. Our results suggest that the AIP can be used as a cost-effective and significant marker for determining WMH in patients with migraine.</p>\",\"PeriodicalId\":19131,\"journal\":{\"name\":\"Neurological Research\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurological Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/01616412.2025.2502784\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01616412.2025.2502784","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Relationship between white matter hyperintensity and atherogenic index of plasma in migraine.
Objective: White matter hyperintensities (WMH) are more commonly observed in patients with migraine compared to the general population; however, their pathophysiology remains incompletely understood. This study aims to investigate the relationship between the atherogenic index of plasma (AIP), a vascular risk marker, and WMH in patients with migraine.
Methods: This study included 274 patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-III). The relationship between WMH and AIP in migraine patients was validated by Two-State Logistic Regression Analysis, and the cubic spline curve was used to determine linearity.
Results: The mean age of the patients with migraine was 36.26 ± 8.37 years and 82.8% (n = 227) were female. The the prevalence of aura (p = 0.028), age (p = 0.001) and mean disease duration (p < 0.001, t=-4.257) were significantly higher in migraine patients with WMH than those without WMH. AIP (p < 0.001, t=-6.667), triglyceride (TG) (p < 0.001, t=-5.736) and body mass index (BMI) (p = 0.020, t=-2.344) were significantly higher in patients with WMH compared to those without WMH. A two-state regression analysis demonstrated a linear relationship between increased AIP (OR:7.101, 95% CI:3.417-14.174), TG (OR: 1.016, 95% CI: 1.005-2.023) and WHM in patients with migraine.
Conclusion: In our study, we found positive correlation between WMH and AIP values in patients with migraine, and showed that AIP values were a statistically significant discriminator of WMH. Our results suggest that the AIP can be used as a cost-effective and significant marker for determining WMH in patients with migraine.
期刊介绍：
Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields.
The scope of the journal includes:
•Stem cell applications
•Molecular neuroscience
•Neuropharmacology
•Neuroradiology
•Neurochemistry
•Biomathematical models
•Endovascular neurosurgery
•Innovation in neurosurgery.
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