Nature Reviews Urology最新文献

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Considering urology in a planetary context 在全球范围内考虑泌尿学
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-03-18 DOI: 10.1038/s41585-025-01019-5
{"title":"Considering urology in a planetary context","authors":"","doi":"10.1038/s41585-025-01019-5","DOIUrl":"10.1038/s41585-025-01019-5","url":null,"abstract":"Recognizing that human healthcare influences the health of our planet and that our environment affects human health is increasingly important. Thus, in recognition of Earth Day and to support research in this area, Nature Reviews Urology presents articles putting the field of urology into a planetary context.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"187-187"},"PeriodicalIF":12.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41585-025-01019-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143641059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the urinary microbiome in genitourinary cancers 泌尿系统微生物群在泌尿生殖系统癌症中的作用
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01011-z
Seoho Lee, Karen Sfanos, Nirmish Singla
{"title":"The role of the urinary microbiome in genitourinary cancers","authors":"Seoho Lee, Karen Sfanos, Nirmish Singla","doi":"10.1038/s41585-025-01011-z","DOIUrl":"https://doi.org/10.1038/s41585-025-01011-z","url":null,"abstract":"<p>Genitourinary cancers account for 20% of cancer instances globally and pose a substantial burden. The microbiome, defined as the ecosystem of organisms that reside within and on the human body, seems to be closely related to multiple cancers. Research on the gut microbiome has yielded substantial insights into the interactions of this entity with the immune system and cancer therapeutic efficacy, whereas the urinary microbiome has been relatively less well-studied. Advances in next-generation sequencing technologies led to new discoveries in the urinary microbiome, which might aid in early detection, risk stratification and personalized treatment strategies in genitourinary cancers. Mechanistic investigations have also suggested a role for the urinary microbiome in modulating the tumour microenvironment and host immune response. For example, distinct urinary microbial signatures have been linked to bladder cancer occurrence and recurrence risk, with specific taxa associated with cytokine production and inflammation. Urinary microbiome signatures have also been explored as potential biomarkers for non-invasive cancer detection. However, challenges remain in standardizing methodologies, validating findings across studies, and establishing causative mechanisms. As investigations into the urinary microbiome continue to evolve, so does the potential for developing microbiome-modulating therapies and enhancing diagnostic capabilities to improve outcomes in patients with genitourinary cancers.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"54 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A complex association with cadmium 与镉的复杂联系
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01022-w
Annette Fenner
{"title":"A complex association with cadmium","authors":"Annette Fenner","doi":"10.1038/s41585-025-01022-w","DOIUrl":"10.1038/s41585-025-01022-w","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"197-197"},"PeriodicalIF":12.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to ambient air pollution increases risk 暴露于环境空气污染会增加风险
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01021-x
Annette Fenner
{"title":"Exposure to ambient air pollution increases risk","authors":"Annette Fenner","doi":"10.1038/s41585-025-01021-x","DOIUrl":"10.1038/s41585-025-01021-x","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"197-197"},"PeriodicalIF":12.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melon seed extract protects against testis metal toxicity 甜瓜种子提取物可防止睾丸金属中毒
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01020-y
Annette Fenner
{"title":"Melon seed extract protects against testis metal toxicity","authors":"Annette Fenner","doi":"10.1038/s41585-025-01020-y","DOIUrl":"10.1038/s41585-025-01020-y","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"197-197"},"PeriodicalIF":12.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chlorination by-products in drinking water — association with bladder cancer risk 饮用水中的氯化副产物与膀胱癌风险的关系
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01017-7
Maria Chiara Masone
{"title":"Chlorination by-products in drinking water — association with bladder cancer risk","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01017-7","DOIUrl":"10.1038/s41585-025-01017-7","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"198-198"},"PeriodicalIF":12.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GSTA2 mitigates DEHP-induced reproductive toxic effects GSTA2减轻dehp诱导的生殖毒性作用
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-03-12 DOI: 10.1038/s41585-025-01016-8
Maria Chiara Masone
{"title":"GSTA2 mitigates DEHP-induced reproductive toxic effects","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01016-8","DOIUrl":"10.1038/s41585-025-01016-8","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"198-198"},"PeriodicalIF":12.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-service training programmes to enhance surgical capacity in a resource-limited setting 在职培训方案,在资源有限的情况下提高手术能力
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-03-12 DOI: 10.1038/s41585-025-01015-9
Maria Chiara Masone
{"title":"In-service training programmes to enhance surgical capacity in a resource-limited setting","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01015-9","DOIUrl":"10.1038/s41585-025-01015-9","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"198-198"},"PeriodicalIF":12.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the effects of prostate cancer therapies on cardiovascular health 评估前列腺癌治疗对心血管健康的影响
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-26 DOI: 10.1038/s41585-025-01002-0
Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi
{"title":"Assessing the effects of prostate cancer therapies on cardiovascular health","authors":"Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi","doi":"10.1038/s41585-025-01002-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01002-0","url":null,"abstract":"<p>Contemporary advances in prostate cancer treatments have markedly improved patient outcomes, yet concerns persist regarding the increased cardiovascular toxicity of prostate cancer treatments, which is multifaceted. Local therapies entail non-negligible cardiovascular risks. The effects of androgen deprivation therapy, which is pivotal in disease management, on cardiovascular health remains contentious, with gonadotropin-releasing hormone agonists and antagonists showing varying cardiovascular outcomes. Despite the ongoing controversy over the cardiovascular risks of gonadotropin-releasing hormone antagonists versus agonists, current evidence does not support favouring one over the other based solely on cardiovascular risk. Combination therapy with androgen receptor pathway inhibitors and androgen deprivation therapy shows additive cardiovascular risks, but robust comparative data are lacking. Chemotherapies such as docetaxel and cabazitaxel, along with emerging targeted therapies and radiopharmaceuticals, are associated with varied cardiovascular risks, necessitating personalized patient assessment. Clinicians should adhere to cardio-oncology guidelines when prescribing therapeutic agents, especially for patients with pre-existing cardiovascular conditions. Optimal monitoring and management strategies are essential to mitigate cardiovascular morbidity and mortality.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"15 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing perioperative care in MIBC: insights from NIAGARA 推进MIBC围手术期护理:来自NIAGARA的见解
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-24 DOI: 10.1038/s41585-025-01009-7
Stephan Brönimann, Shahrokh F. Shariat
{"title":"Advancing perioperative care in MIBC: insights from NIAGARA","authors":"Stephan Brönimann, Shahrokh F. Shariat","doi":"10.1038/s41585-025-01009-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01009-7","url":null,"abstract":"The results of the NIAGARA trial have considerably advanced treatment for patients with muscle-invasive bladder cancer, establishing a new therapeutic standard for cisplatin-eligible patients. Future trials will help to answer remaining questions about perioperative treatment optimization.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"10 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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