Nature Reviews Urology最新文献_第5页

Electrical stimulation for the hypocontractile bladder 电刺激治疗收缩功能减退的膀胱

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-30 DOI: 10.1038/s41585-024-00949-w

Nima Nassiri, Lauren Schafrank, Michael Chen, Madeleine Burg, Victor Nitti

引用次数: 0

Measuring and improving the cradle-to-grave environmental performance of urological procedures 衡量和改进泌尿外科手术从摇篮到坟墓的环境绩效

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-27 DOI: 10.1038/s41585-024-00937-0

Joseph B. John, William K. Gray, Tim W. R. Briggs, John S. McGrath

{"title":"Measuring and improving the cradle-to-grave environmental performance of urological procedures","authors":"Joseph B. John, William K. Gray, Tim W. R. Briggs, John S. McGrath","doi":"10.1038/s41585-024-00937-0","DOIUrl":"https://doi.org/10.1038/s41585-024-00937-0","url":null,"abstract":"<p>An urgent need for societal transformation exists to reduce the environmental impact of humanity, because environmental health affects human health. Health care causes ~5% of global greenhouse gas emissions and other substantial and ongoing environmental harms. Thus, health-care professionals and managers must lead ongoing efforts to improve the environmental performance of health systems. Life-cycle assessment (LCA) is a methodology that enables estimation of environmental impacts of products and processes. It models environmental effects from ‘cradle’ (raw material extraction) to ‘grave’ (end of useful life) and conventionally reports a range of different impact categories. LCA is a valuable tool when used appropriately. Maximizing its utility requires rational assumptions alongside careful consideration of system boundaries and data sources. Well-executed LCAs are detailed and transparently reported, enabling findings to be adapted or generalized to different settings. Attention should be given to modelling mitigation solutions in LCAs. This important step can guide health-care systems towards new and innovative solutions that embed progress towards international climate agreements. Many urological conditions are common, recurrent or chronic, requiring resource-intensive management with large associated environmental impacts. LCAs in urology have predominantly focussed on greenhouse gas emissions and have enabled identification of modifiable ‘hotspots’ including electricity use, travel, single-use items, irrigation, reprocessing and waste incineration. However, the methodological and reporting quality of published urology LCAs generally requires improvement and standardization. Health-care evaluation and commissioning frameworks that value LCA findings alongside clinical outcomes and cost could accelerate sustainable innovations. Rapid implementation strategies for known environmentally sustainable solutions are also needed.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"58 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary bladder transplantation in humans - current status and future perspectives. 人类膀胱移植--现状与未来展望。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-20 DOI: 10.1038/s41585-024-00935-2

Michał C Czarnogórski,Krzysztof Koper,Piotr Petrasz,Malte W Vetterlein,Marta Pokrywczyńska,Kajetan Juszczak,Tomasz Drewa,Jan Adamowicz

{"title":"Urinary bladder transplantation in humans - current status and future perspectives.","authors":"Michał C Czarnogórski,Krzysztof Koper,Piotr Petrasz,Malte W Vetterlein,Marta Pokrywczyńska,Kajetan Juszczak,Tomasz Drewa,Jan Adamowicz","doi":"10.1038/s41585-024-00935-2","DOIUrl":"https://doi.org/10.1038/s41585-024-00935-2","url":null,"abstract":"Urinary bladder vascularized allograft transplantation in humans is currently extensively being investigated worldwide, owing to the theoretical potential of this approach as a therapeutic option for individuals with end-stage, non-oncological bladder conditions or congenital bladder pathologies. To date, a successful attempt at urinary bladder autotransplantation was carried out in a heart-beating brain-dead research human donor. The robot-assisted surgical technique was shown to be optimal for performing this procedure, achieving a good performance in terms of both bladder allograft collection as well as vascular, ureterovesical and vesicourethral anastomoses. The urinary bladder vascularized allograft would be an alternative to traditional urinary diversion methods that rely on the use of intestinal segments, potentially avoiding adverse effects associated with these approaches. However, different from ileal urinary diversion, bladder transplantation would require lifelong immune suppression. Clinical trials are in progress to assess the vascularized bladder allograft transplantation technique, as well as the safety of this procedure in oncological and non-oncological indications.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"77 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota influence bladder tumour development 肠道微生物群影响膀胱肿瘤的发展

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-09-16 DOI: 10.1038/s41585-024-00947-y

Louise Lloyd

引用次数: 0

Prescribing clinician specialty influences adherence to PrEP 开处方的临床医生专业影响 PrEP 的依从性

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00945-0

Maria Chiara Masone

引用次数: 0

piRNA pathway disruption in human infertility 人类不孕症中的 piRNA 通路干扰

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00946-z

Maria Chiara Masone

引用次数: 0

A wearable UBVM device to monitor bladder volume 监测膀胱容量的可穿戴 UBVM 设备

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00944-1

Maria Chiara Masone

引用次数: 0

Intralesional heterogeneity on PSMA PET–CT predicts mCRPC outcomes PSMA PET-CT 显示的区域内异质性可预测 mCRPC 的预后

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00943-2

Maria Chiara Masone

引用次数: 0

AI in prostate MRI: enhancing accuracy and reducing overdiagnosis 前列腺磁共振成像中的人工智能：提高准确性并减少过度诊断

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-11 DOI: 10.1038/s41585-024-00940-5

Baris Turkbey

引用次数: 0

Human sperm RNA in male infertility 男性不育症中的人类精子 RNA

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-10 DOI: 10.1038/s41585-024-00920-9

Rossella Cannarella, Andrea Crafa, Roberto Curto, Laura M. Mongioì, Vincenzo Garofalo, Vittorio Cannarella, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero

{"title":"Human sperm RNA in male infertility","authors":"Rossella Cannarella, Andrea Crafa, Roberto Curto, Laura M. Mongioì, Vincenzo Garofalo, Vittorio Cannarella, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero","doi":"10.1038/s41585-024-00920-9","DOIUrl":"https://doi.org/10.1038/s41585-024-00920-9","url":null,"abstract":"<p>The function and value of specific sperm RNAs in apparently idiopathic male infertility are currently poorly understood. Whether differences exist in the sperm RNA profile between patients with infertility and fertile men needs clarification. Similarly, the utility of sperm RNAs in predicting successful sperm retrieval and assisted reproductive technique (ART) outcome is unknown. Patients with infertility and fertile individuals seem to have differences in the expression of non-coding RNAs that regulate genes controlling spermatogenesis. Several RNAs seem to influence embryo quality and development. Also, RNA types seem to predict successful sperm retrieval in patients with azoospermia. These findings suggest that sperm RNAs could influence decision-making during the management of patients with infertility. This evidence might help to identify possible therapeutic approaches aimed at modulating the expression of dysregulated genes in patients with infertility. Performing prospective studies with large sample sizes is necessary to investigate cost-effective panels consisting of proven molecular targets to ensure that this evidence can be translated to clinical practice.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"382 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0