Nature Reviews Urology最新文献_第5页

Art, science and clinical urology with a Capitol AUA 艺术，科学和临床泌尿科与国会AUA。

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-05 DOI: 10.1038/s41585-026-01165-4

Annette Fenner

引用次数: 0

Epigenetic modulation of prostate cancer disparities in men with African ancestry. 非洲裔男性前列腺癌差异的表观遗传学调节。

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-05 DOI: 10.1038/s41585-026-01157-4

Jenna Craddock, Vanessa M Hayes

{"title":"Epigenetic modulation of prostate cancer disparities in men with African ancestry.","authors":"Jenna Craddock, Vanessa M Hayes","doi":"10.1038/s41585-026-01157-4","DOIUrl":"https://doi.org/10.1038/s41585-026-01157-4","url":null,"abstract":"Prostate cancer disproportionately affects men of African ancestry, yet the molecular mechanisms underlying these disparities remain poorly defined. Genomic studies have begun to reveal ancestry-linked risk alleles and somatic alterations, but the role of epigenetic dysregulation is only emerging. Drawing on multi-ancestral comparative analyses, with emphasis on cohorts from sub-Saharan Africa, we speculate that germline and somatic variation converge in epigenetic machinery genes to drive tumour evolution. African tumours harbour a heightened burden and diversity of both inherited and acquired variants, supporting a model of 'oncogenic cooperation' whereby germline diversity interacts with somatic mutations to broaden the range of pathogenic interactions. Limited yet complementary methylation analyses reveal tumour-specific and ancestry-specific reprogramming of promoters, enhancers and heterochromatin, suggesting that African tumours might be epigenetically primed for aggressive phenotypes. Chromatin remodelling defects emerge as potentially under-recognized disparity drivers, promoting genomic instability, altered gene regulation and therapeutic resistance. Collectively, these findings support a genome-epigenome-environment model in which inherited susceptibility, somatic variation and environmentally reinforced epigenetic reprogramming converge to shape aggressive African-associated prostate cancer. However, current insights are limited by European-centred baselines, under-representation of African cohorts and platform mismatches. Reducing prostate cancer health disparities requires equitable prostate cancer genomics and epigenomic research efforts that embrace the rich African ancestral population identifier.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoring time lost to race-based medicine. 恢复因种族医学而失去的时间。

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-04 DOI: 10.1038/s41585-026-01161-8

George Gheordunescu, Randy A Vince

引用次数: 0

The clinical utility of prostate MRI before biopsy 前列腺活检前MRI的临床应用。

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-04 DOI: 10.1038/s41585-026-01143-w

Connor Chestnut, Trevor McKoy, Antonio C. Westphalen, Daniel W. Lin, Yaw A. Nyame

{"title":"The clinical utility of prostate MRI before biopsy","authors":"Connor Chestnut, Trevor McKoy, Antonio C. Westphalen, Daniel W. Lin, Yaw A. Nyame","doi":"10.1038/s41585-026-01143-w","DOIUrl":"10.1038/s41585-026-01143-w","url":null,"abstract":"Approximately 1 in 8 men are diagnosed with prostate cancer during their lifetime. However, long-term data have shown that as many as half of diagnosed prostate cancers have low lethal potential. Early detection of prostate cancer relying on PSA alone is associated with potential harm to patients owing to false-positive results, prostate biopsy-related complications and over-detection and over-treatment of low-risk cancers. Multiparametric MRI offers an adjunctive strategy for improving the diagnostic yield of prostate biopsy and also for potentially reducing the need for biopsy in selected patients. Prostate MRI can increase the detection of clinically significant prostate cancer through targeted biopsy, especially in patients with a previous negative biopsy who did not undergo initial imaging. Prostate MRI improves clinically significant cancer detection, potentially reducing biopsy burden in patients on active surveillance. This Review discusses evidence of the utility of MRI before biopsy in the prostate cancer diagnostic pathway, particularly considering biopsy-naive patients, patients with previous negative biopsies and patients on active surveillance. Future perspectives of combining MRI with biomarkers and/or other novel biopsy modalities to improve the detection of clinically significant cancers are also explored.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"23 8","pages":"542-550"},"PeriodicalIF":13.6,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence. 聚丙烯网片降解和全身性疾病：生物学上的合理性不是临床证据。

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-02 DOI: 10.1038/s41585-026-01158-3

Bilal Chughtai, Jennifer Polo, Howard B Goldman

引用次数: 0

Reply to 'Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence'. 回复“聚丙烯网片降解和全身性疾病：生物学合理性不是临床证据”。

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-02 DOI: 10.1038/s41585-026-01159-2

Nicholas T H Farr, Pascal Achenbach, Karl-Dietrich Sievert

引用次数: 0

Single-cell and spatial RNA sequencing in prostate cancer 前列腺癌的单细胞和空间RNA测序。

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-05-28 DOI: 10.1038/s41585-026-01149-4

Amin Ali, Migle Mikutenaite, Joachim Weischenfeldt, Robert G. Bristow

{"title":"Single-cell and spatial RNA sequencing in prostate cancer","authors":"Amin Ali, Migle Mikutenaite, Joachim Weischenfeldt, Robert G. Bristow","doi":"10.1038/s41585-026-01149-4","DOIUrl":"10.1038/s41585-026-01149-4","url":null,"abstract":"Single-cell RNA sequencing (scRNA-seq) has become an indispensable tool in prostate biology research, considerably advancing our understanding from organ development to disease initiation and progression. This technology has provided profound insights into prostate disease, from benign prostatic hyperplasia to metastatic prostate cancer, particularly with respect to the tumour microenvironment, cellular lineage plasticity and resistance to androgen receptor-dependent therapies. scRNA-seq has revealed complex and potentially targetable interactions between epithelial, stromal and immune subtypes driving disease heterogeneity. As a complementary technology, spatial transcriptomics enables the characterization of tumour architecture using spatial resolution at the single-cell or multi-cell level. Importantly, these approaches also permit bioinformatic inference of large-scale copy number variants, enabling integrated genomic–transcriptomic analysis of clonal evolution and therapy resistance. Understanding the biological consequences of this heterogeneity could support patient sub-stratification, biomarker development and therapeutic strategies targeting genomic instability or tumour microenvironment interactions. In this Review, the authors describe current applications of single-cell transcriptomics in prostate cancer, including advantages, challenges and technical considerations. Molecular findings are summarized and how insights from single-cell and spatial transcriptomics, together with integrated multiomic analyses, could advance understanding are discussed.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"23 10","pages":"672-690"},"PeriodicalIF":13.6,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symptoms and subtypes of patients with lower urinary tract dysfunction - insights from the Symptoms of Lower Urinary Tract Dysfunction Research Network. 下尿路功能障碍患者的症状和亚型——来自下尿路功能障碍症状研究网络的见解

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2026-05-27 DOI: 10.1038/s41585-026-01155-6

Claire C Yang, Ziya Kirkali, Anne P Cameron, H Henry Lai, David Cella, Victor P Andreev, Karl J Kreder, Catherine S Bradley, Brian T Helfand, J Quentin Clemens, Cindy L Amundsen, Abigail R Smith, Kevin P Weinfurt

{"title":"Symptoms and subtypes of patients with lower urinary tract dysfunction - insights from the Symptoms of Lower Urinary Tract Dysfunction Research Network.","authors":"Claire C Yang, Ziya Kirkali, Anne P Cameron, H Henry Lai, David Cella, Victor P Andreev, Karl J Kreder, Catherine S Bradley, Brian T Helfand, J Quentin Clemens, Cindy L Amundsen, Abigail R Smith, Kevin P Weinfurt","doi":"10.1038/s41585-026-01155-6","DOIUrl":"https://doi.org/10.1038/s41585-026-01155-6","url":null,"abstract":"Lower urinary tract dysfunction presents with a wide range of bothersome urinary symptoms, which are common in both men and women, with incidence and prevalence increasing with age. Individuals with lower urinary tract symptoms (LUTS) suffer from the chronicity of their symptoms, have a reduced quality of life, and experience high morbidity with associated medical conditions. Various treatment options exist, but many patients do not find satisfactory or lasting relief. The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) was formed in 2012 with the goals of improving methods for assessing patient-reported experiences with LUTS; identifying and describing patient subtypes; and generating data, research tools and biological samples for future studies. LURN developed three self-report instruments for measuring LUTS. More than 1,000 men and women with LUTS seeking treatment were enrolled, and completed a baseline and interval assessments throughout a 12-month observational period. Findings from LURN studies showed that various biological, non-urological, psychosocial and behavioural factors contribute to the development and persistence of LUTS. Additionally, patients seeking care for LUTS often present with a wider variety of urological symptoms than previously thought. Diagnoses for these patients do not reliably fit into traditional categories such as overactive bladder or BPH. LURN has addressed its objectives by creating new, top-tier assessment tools; conducting studies to gather clinically relevant data to identify potential new and accurate patient subtypes; and collecting a wealth of data and biological samples for future research to continue subtype refinement.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: HER2 in urothelial cancer: clinical speed outpacing diagnostic clarity. 出版者更正：HER2在尿路上皮癌：临床速度超过诊断清晰度。

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2026-05-27 DOI: 10.1038/s41585-026-01160-9

Emanuele Crupi, Filippo Pederzoli, Robert A Huddart, Liang Cheng, Daniele Raggi

引用次数: 0

Prostatic acid phosphatase: a rediscovered target in prostate cancer. 前列腺酸性磷酸酶：前列腺癌的一个重新发现的靶点。

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2026-05-22 DOI: 10.1038/s41585-026-01156-5

Daniel Koehler, Tobias Maurer

引用次数: 0