Nature Reviews Urology最新文献_第6页

Cell death score predicts prostate cancer metastasis and immunotherapy response 细胞死亡评分可预测前列腺癌转移和免疫疗法反应

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-10 DOI: 10.1038/s41585-024-00954-z

Maria Chiara Masone

引用次数: 0

Interactions between androgen and IGF1 axes in prostate tumorigenesis 雄激素和 IGF1 轴在前列腺肿瘤发生中的相互作用

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-07 DOI: 10.1038/s41585-024-00942-3

Yao Mawulikplimi Adzavon, Zoran Culig, Zijie Sun

{"title":"Interactions between androgen and IGF1 axes in prostate tumorigenesis","authors":"Yao Mawulikplimi Adzavon, Zoran Culig, Zijie Sun","doi":"10.1038/s41585-024-00942-3","DOIUrl":"https://doi.org/10.1038/s41585-024-00942-3","url":null,"abstract":"Androgen signalling through the androgen receptor (AR) is essential for prostate tumorigenesis. However, androgen signalling pathways also interact with other growth factor-mediated signalling pathways to regulate the prostatic cell cycle, differentiation, apoptosis and proliferation in the initiation and progression of prostate cancer. Insulin-like growth factor 1 (IGF1) is one of the most prominent growth factors in prostate tumorigenesis. Clinical and experimental evidence has demonstrated that IGF1 signalling supports both androgen-dependent and androgen-independent prostate tumorigenesis, suggesting that improved understanding of the interactions between the IGF1 and androgen axes might aid the development of new therapeutic strategies. Available data have shown a dynamic role of androgen–AR signalling in the activation of IGF1-signalling pathways by augmenting transcription of the IGF1 receptor in prostatic basal epithelial cells and by increasing IGF1 secretion through the suppression of IGF-binding protein 3 expression in prostatic stromal cells. In turn, IGF1 stimulates Wnt–β-catenin signalling in prostatic basal progenitors to promote prostatic oncogenic transformation and prostate cancer development. These findings highlight the cooperative, autocrine and paracrine interactions that underlie the oncogenic effects of androgens and IGF1 and open up new opportunities for therapeutic targeting.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"224 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-based diets and urological health 植物性饮食与泌尿系统健康

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-07 DOI: 10.1038/s41585-024-00939-y

Stacy Loeb, James F. Borin, Greeshma Venigalla, Manish Narasimman, Natasha Gupta, Alexander P. Cole, Katherine Amin

{"title":"Plant-based diets and urological health","authors":"Stacy Loeb, James F. Borin, Greeshma Venigalla, Manish Narasimman, Natasha Gupta, Alexander P. Cole, Katherine Amin","doi":"10.1038/s41585-024-00939-y","DOIUrl":"https://doi.org/10.1038/s41585-024-00939-y","url":null,"abstract":"Plant-based diets have grown in popularity owing to multiple health and environmental benefits. Some evidence suggests that plant-based diets are associated with benefits for urological health. In genitourinary oncology, most research has focused on prostate cancer. Clinical trial results suggest a favourable influence of healthy lifestyle modifications including plant-based diets before and after prostate cancer treatment. Epidemiological evidence shows that a diet higher in plant-based and lower in animal-based food is associated with a lower risk of aggressive prostate cancer and better quality-of-life scores than a diet with less plant-based and more animal-based food. Studies on bladder and kidney cancer are scarce, but limited data suggest that vegetarian or plant-forward dietary patterns (increased consumption of fruits and vegetables and minimizing meat) are associated with a lower risk of development of these cancers than dietary patterns with fewer fruits and vegetables and more meat. With respect to benign urological conditions, epidemiological studies suggest that plant-based dietary patterns are associated with a lower risk of benign prostatic hyperplasia and urinary tract infections than non-plant-based dietary patterns. Compared with diets high in animal-based foods and low in plant-based foods, a substantial body of epidemiological evidence also suggests that increased consumption of healthy plant-based food is associated with a lower risk of erectile dysfunction. Plant-based dietary patterns that are high in fruits and vegetables with normal calcium intake, while limiting animal protein and salt, are associated with a lower risk of kidney stone development than dietary patterns that do not follow these parameters. Overall, increasing consumption of plant-based foods and reducing intake of animal-based foods has favourable associations with multiple urological conditions.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"6 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pimping in the clinical learning environment: representation of women in surgery 临床学习环境中的 "拉皮条"：女性在外科手术中的代表性

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-01 DOI: 10.1038/s41585-024-00950-3

Efe Chantal Ghanney Simons, John J. Guardiola, Indira Bhavsar-Burke

引用次数: 0

Metaverse in surgery — origins and future potential 外科中的元宇宙--起源与未来潜力

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-30 DOI: 10.1038/s41585-024-00941-4

Enrico Checcucci, Alessandro Veccia, Stefano Puliatti, Pieter De Backer, Pietro Piazza, Karl-Friedrich Kowalewski, Severin Rodler, Mark Taratkin, Ines Rivero Belenchon, Loic Baekelandt, Sabrina De Cillis, Alberto Piana, Ahmed Eissa, Juan Gomez Rivas, Giovanni Cacciamani, Francesco Porpiglia

{"title":"Metaverse in surgery — origins and future potential","authors":"Enrico Checcucci, Alessandro Veccia, Stefano Puliatti, Pieter De Backer, Pietro Piazza, Karl-Friedrich Kowalewski, Severin Rodler, Mark Taratkin, Ines Rivero Belenchon, Loic Baekelandt, Sabrina De Cillis, Alberto Piana, Ahmed Eissa, Juan Gomez Rivas, Giovanni Cacciamani, Francesco Porpiglia","doi":"10.1038/s41585-024-00941-4","DOIUrl":"https://doi.org/10.1038/s41585-024-00941-4","url":null,"abstract":"The metaverse refers to a collective virtual space that combines physical and digital realities to create immersive, interactive environments. This space is powered by technologies such as augmented reality (AR), virtual reality (VR), artificial intelligence (AI) and blockchain. In healthcare, the metaverse can offer many applications. Specifically in surgery, potential uses of the metaverse include the possibility of conducting immersive surgical training in a VR or AR setting, and enhancing surgical planning through the adoption of three-dimensional virtual models and simulated procedures. At the intraoperative level, AR-guided surgery can assist the surgeon in real time to increase surgical precision in tumour identification and selective management of vessels. In post-operative care, potential uses of the metaverse include recovery monitoring and patient education. In urology, AR and VR have been widely explored in the past decade, mainly for surgical navigation in prostate and kidney cancer surgery, whereas only anecdotal metaverse experiences have been reported to date, specifically in partial nephrectomy. In the future, further integration of AI will improve the metaverse experience, potentially increasing the possibility of carrying out surgical navigation, data collection and virtual trials within the metaverse. However, challenges concerning data security and regulatory compliance must be addressed before the metaverse can be used to improve patient care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"26 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrical stimulation for the hypocontractile bladder 电刺激治疗收缩功能减退的膀胱

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-30 DOI: 10.1038/s41585-024-00949-w

Nima Nassiri, Lauren Schafrank, Michael Chen, Madeleine Burg, Victor Nitti

引用次数: 0

Measuring and improving the cradle-to-grave environmental performance of urological procedures 衡量和改进泌尿外科手术从摇篮到坟墓的环境绩效

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-27 DOI: 10.1038/s41585-024-00937-0

Joseph B. John, William K. Gray, Tim W. R. Briggs, John S. McGrath

{"title":"Measuring and improving the cradle-to-grave environmental performance of urological procedures","authors":"Joseph B. John, William K. Gray, Tim W. R. Briggs, John S. McGrath","doi":"10.1038/s41585-024-00937-0","DOIUrl":"https://doi.org/10.1038/s41585-024-00937-0","url":null,"abstract":"An urgent need for societal transformation exists to reduce the environmental impact of humanity, because environmental health affects human health. Health care causes ~5% of global greenhouse gas emissions and other substantial and ongoing environmental harms. Thus, health-care professionals and managers must lead ongoing efforts to improve the environmental performance of health systems. Life-cycle assessment (LCA) is a methodology that enables estimation of environmental impacts of products and processes. It models environmental effects from ‘cradle’ (raw material extraction) to ‘grave’ (end of useful life) and conventionally reports a range of different impact categories. LCA is a valuable tool when used appropriately. Maximizing its utility requires rational assumptions alongside careful consideration of system boundaries and data sources. Well-executed LCAs are detailed and transparently reported, enabling findings to be adapted or generalized to different settings. Attention should be given to modelling mitigation solutions in LCAs. This important step can guide health-care systems towards new and innovative solutions that embed progress towards international climate agreements. Many urological conditions are common, recurrent or chronic, requiring resource-intensive management with large associated environmental impacts. LCAs in urology have predominantly focussed on greenhouse gas emissions and have enabled identification of modifiable ‘hotspots’ including electricity use, travel, single-use items, irrigation, reprocessing and waste incineration. However, the methodological and reporting quality of published urology LCAs generally requires improvement and standardization. Health-care evaluation and commissioning frameworks that value LCA findings alongside clinical outcomes and cost could accelerate sustainable innovations. Rapid implementation strategies for known environmentally sustainable solutions are also needed.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"58 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary bladder transplantation in humans - current status and future perspectives. 人类膀胱移植--现状与未来展望。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-20 DOI: 10.1038/s41585-024-00935-2

Michał C Czarnogórski,Krzysztof Koper,Piotr Petrasz,Malte W Vetterlein,Marta Pokrywczyńska,Kajetan Juszczak,Tomasz Drewa,Jan Adamowicz

{"title":"Urinary bladder transplantation in humans - current status and future perspectives.","authors":"Michał C Czarnogórski,Krzysztof Koper,Piotr Petrasz,Malte W Vetterlein,Marta Pokrywczyńska,Kajetan Juszczak,Tomasz Drewa,Jan Adamowicz","doi":"10.1038/s41585-024-00935-2","DOIUrl":"https://doi.org/10.1038/s41585-024-00935-2","url":null,"abstract":"Urinary bladder vascularized allograft transplantation in humans is currently extensively being investigated worldwide, owing to the theoretical potential of this approach as a therapeutic option for individuals with end-stage, non-oncological bladder conditions or congenital bladder pathologies. To date, a successful attempt at urinary bladder autotransplantation was carried out in a heart-beating brain-dead research human donor. The robot-assisted surgical technique was shown to be optimal for performing this procedure, achieving a good performance in terms of both bladder allograft collection as well as vascular, ureterovesical and vesicourethral anastomoses. The urinary bladder vascularized allograft would be an alternative to traditional urinary diversion methods that rely on the use of intestinal segments, potentially avoiding adverse effects associated with these approaches. However, different from ileal urinary diversion, bladder transplantation would require lifelong immune suppression. Clinical trials are in progress to assess the vascularized bladder allograft transplantation technique, as well as the safety of this procedure in oncological and non-oncological indications.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"77 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota influence bladder tumour development 肠道微生物群影响膀胱肿瘤的发展

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-09-16 DOI: 10.1038/s41585-024-00947-y

Louise Lloyd

引用次数: 0

Prescribing clinician specialty influences adherence to PrEP 开处方的临床医生专业影响 PrEP 的依从性

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00945-0

Maria Chiara Masone

引用次数: 0