Nature Reviews Urology最新文献

{"title":"Reply to 'Should we screen for sleep apnoea in men with idiopathic infertility?'","authors":"Tessa Lord","doi":"10.1038/s41585-025-01094-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01094-8","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"126 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we screen for sleep apnoea in men with idiopathic infertility?","authors":"Tathiana A Alvarenga,Matheus Brandão Vasco,Bianca Camilo Schimenes,Sergio Tufik,Monica Levy Andersen","doi":"10.1038/s41585-025-01093-9","DOIUrl":"https://doi.org/10.1038/s41585-025-01093-9","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"99 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The opportunities and barriers for developing tumour-infiltrating lymphocyte therapy for patients with advanced genitourinary cancers.","authors":"Marine Potez,Gabriel Roman Souza,Philippe E Spiess,Shari Pilon-Thomas,Jad Chahoud","doi":"10.1038/s41585-025-01088-6","DOIUrl":"https://doi.org/10.1038/s41585-025-01088-6","url":null,"abstract":"Adoptive cell therapy using tumour-infiltrating lymphocytes (TILs) has been a very successful model of enhancing immune-based therapies. Clinical benefits have been shown for patients with advanced melanoma, leading to the first FDA approval for this immune modality in 2024. Although clinical trials conducted decades ago for advanced renal-cell cancer did not show significant clinical benefits, recent advances in the TIL generation process, manipulation techniques, preparative regimens and combination with immune checkpoint inhibitors offer new hope for reexploring optimized TIL therapy for genitourinary cancers. The current landscape of TIL therapy has seen progress in TIL manufacturing, optimization and delivery methodologies that have the potential to improve the safety and efficacy of TIL therapy in the management of advanced genitourinary malignancies. Furthermore, innovative combination approaches and novel strategies could enhance the clinical viability of TIL therapy and warrant evaluation in clinical trials treating patients with genitourinary cancers.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"4 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise, diet and psychological support for patients with testicular cancer.","authors":"Logan G Briggs,Sarah P Psutka,Matthew J Van Ligten,Kelsey L Beck,Debarshi Sinha,Vikram S Gill,Khalid Y Alkhatib,Adri M Durant,Paul A Bain,Jaxon Quillen,Christopher Dodoo,Phillip M Pierorazio,Haidar Abdul-Muhsin,Mark D Tyson,Quoc-Dien Trinh,Sara C Parke","doi":"10.1038/s41585-025-01089-5","DOIUrl":"https://doi.org/10.1038/s41585-025-01089-5","url":null,"abstract":"Prehabilitative and rehabilitative exercise, psychological support and nutrition interventions have proven beneficial in many cancer populations. Testicular cancer survivors have high rates of metabolic syndrome, cardiovascular disease, hypogonadism and psychosocial issues, and might yield greater benefit from such interventions than the average cancer survivor population. Results from the few studies available in this field suggest that exercise can improve fatigue, metabolic syndrome, cardiovascular risk profile and physical performance measures (such as VO2 max), whereas psychological support programmes have been shown to improve fatigue and mental health. However, a paucity of data exists on best practices for provision of nutrition, exercise and psychological support within the testicular cancer space, patients and caregivers, highlighting the urgent need for additional work in this field. Overall, prehabilitation and rehabilitation interventions for testicular cancer are safe and efficacious, and should be implemented by clinicians at diagnosis and throughout survivorship.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"2 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End of the TRUS era: transperineal biopsy takes the lead in prostate cancer detection","authors":"David Hennes, Abdullah Al-Khanaty, David C. Chen, Eoin Dinneen, Christa Babst, Nathan Lawrentschuk, Marlon L. Perera, Declan G. Murphy","doi":"10.1038/s41585-025-01090-y","DOIUrl":"https://doi.org/10.1038/s41585-025-01090-y","url":null,"abstract":"Transrectal ultrasound-guided prostate biopsy is associated with limitations including high infection rates, sampling limitations and patient discomfort, which have led to the development of the transperineal approach. Randomized trials show that transperineal biopsy offers at least equivalent detection of clinically significant prostate cancer, providing robust evidence for a clinical practice change.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"36 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring promising biomarkers based on pathogenic mechanisms in interstitial cystitis/bladder pain syndrome","authors":"Kerong Xin, Siyu Wu, Rong Li, Chiyu Tan, Yuanhong Jiang, Jiazheng Yu, Xu Liu, Shijie Li, Zhenhua Li, Xiaonan Chen","doi":"10.1038/s41585-025-01078-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01078-8","url":null,"abstract":"<p>Interstitial cystitis/bladder pain syndrome (IC/BPS), characterized by bladder discomfort and lower urinary tract symptoms, is often either overtreated or undertreated owing to the complexity and variability of symptoms and the lack of reliable diagnostic tools, leading to reduced quality of life and prolonged illness. The pathophysiology of IC/BPS remains unclear, with multiple hypotheses — such as autoimmune inflammation, oxidative stress and urothelial dysfunction — offering potential explanations. Consequently, a diverse range of urinary biomarkers has emerged, although their diagnostic reliability remains inconsistent. As technology advances, biomarkers are increasingly shifting towards multiplex assays, encompassing genomics, transcriptomics, proteomics and cell-based methods; however, cutting-edge research and clinical validation are not yet integrated into the limited diagnostic tools available. Clinical phenotypes from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network studies provide multi-level biomarker research — including molecular, imaging and other modalities — to support the diagnosis of IC/BPS. Integrating these observations will advance the development of precision medicine for the diagnosis of IC/BPS, thereby improving management of this complex condition.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"118 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-grade non-muscle-invasive bladder cancer: molecular landscape, treatment strategies and emerging therapies","authors":"Lexiaochuan Wen, Hiroko Miyagi, Philippe E. Spiess, Alice Yu, Cathy L. Mendelsohn, Wei Shen Tan, Sarah P. Psutka, Seth P. Lerner, Liang Cheng, Lars Dyrskjøt, Joshua J. Meeks, Shahrokh F. Shariat, Paolo Gontero, Benjamin Pradere, Gary D. Steinberg, Ashish M. Kamat, Roger Li","doi":"10.1038/s41585-025-01072-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01072-0","url":null,"abstract":"<p>Low-grade non-muscle invasive bladder cancer is a specific category of bladder cancer with a favourable prognosis; however, its management presents several challenges. The risk of stage progression is very low, but approximately half of patients will experience recurrence within the first 5 years after diagnosis. This high propensity for recurrence, coupled with the threat of progression, mandates ongoing surveillance. However, the optimal frequency and duration of follow-up monitoring remain undefined. Current management strategies for low-grade non-muscle invasive bladder cancer rely heavily on routine office cystoscopy, with few advances in diagnostic and treatment options over the past 25 years. Our basic understanding of disease biology has substantially advanced. However, at present, considerable variations in clinical practice exist, with implications for increased financial and treatment burden for patients and health care systems. Molecular signatures and biomarker discoveries are crucial to understand disease behaviour and inform novel treatment strategies. Emerging therapies, such as advanced drug-delivery systems, immunomodulatory agents and targeted therapies, offer the potential to improve patient outcomes, streamline management and reduce the need for surveillance cystoscopies. Actionable avenues for future research in the field include prospective validation of novel biomarkers and therapies with the ultimate aim of optimizing patient care and reducing health care costs.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"6 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New evidence and novel techniques for assessing intraoperative margins during radical prostatectomy","authors":"Siyu Huang, David C. Chen, David Hennes, Declan G. Murphy, Nathan Lawrentschuk, Marlon L. Perera","doi":"10.1038/s41585-025-01087-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01087-7","url":null,"abstract":"New evidence shows that NeuroSAFE, an intraoperative frozen section technique during radical prostatectomy, improves erectile function recovery. Traditional NeuroSAFE using frozen section analysis might not work for all centres, but new technologies for intraoperative margin assessment might facilitate more pragmatic alternatives during radical prostatectomy.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"31 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current landscape of single-port robotic surgery in urology","authors":"Arianna Biasatti, Nicolas A. Soputro, Francesco Porpiglia, Sisto Perdonà, Firas Abdollah, Ryan Nelson, Craig Rogers, Lee C. Zhao, Ahmed Ghazi, Ben Challacombe, Christopher Eden, Agostino Mattei, Christian D. Fankhauser, Alberto Breda, Bernardo Rocco, Francesco Montorsi, Alberto Briganti, Antony A. Pellegrino, Alexandre Mottrie, Ruben De Groote, Alexander Haese, Markus Graefen, Marcio C. Moschovas, Vipul Patel, Giuseppe Simone, Antonio Galfano, Silvia Secco, Riccardo Bertolo, Savio D. Pandolfo, Vito Pansadoro, Filipe L. F. Carvalho, Jean V. Joseph, Mohammad Ramadan, Jaschar Shakuri-Rad, Bertram Yuh, Jeffrey Nix, David I. Lee, Soroush Rais-Bahrami, Sij Hemal, Mohamed Eltemamy, Alp T. Beksac, Zeyad Schwen, Li-Ming Su, Maurizio Buscarini, Michael Palese, Ash Tewari, Peter Wiklund, Edward E. Cherullo, Srinivas Vourganti, Jennifer A. Linehan, Zhenjie Wu, Michael Stifelman, Mutahar Ahmed, Reza Mehrazin, Ketan Badani, Richard E. Link, Simone Crivellaro, Jihad Kaouk, Riccardo Autorino","doi":"10.1038/s41585-025-01081-z","DOIUrl":"https://doi.org/10.1038/s41585-025-01081-z","url":null,"abstract":"<p>The advent of the purpose-built da Vinci single-port robotic platform marks a pivotal advancement in minimally invasive urological surgery. Designed to overcome the ergonomic and technical limitations of prior single-site approaches, the single-port system enables complex procedures through a single incision, with enhanced dexterity, optimized use of confined spaces and improved cosmetic and peri-operative outcomes. The single-port system has been increasingly used across a wide range of urological indications, including robot-assisted radical prostatectomy, partial nephrectomy, nephroureterectomy and reconstructive surgeries such as pyeloplasty and ureteral re-implantation. Innovative access strategies, such as the single-port transvesical and low anterior access approaches, have facilitated regionalized and multi-quadrant surgeries without the need for repositioning or robot re-docking. These advances have translated into reduced morbidity, faster recovery and increased feasibility of opioid-sparing, same-day discharge protocols. As surgical expertise deepens and technology evolves, the single-port robotic platform stands as a refinement of minimally invasive surgery, and also as a potential paradigm shift in urological practice.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"58 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to ‘Enhancing spatial transcriptomics in clear-cell renal cell carcinoma’","authors":"Jesper Jespersen, Iben Lyskjær","doi":"10.1038/s41585-025-01086-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01086-8","url":null,"abstract":"<p>We appreciate the thoughtful feedback from Chengming Li, Junxiu Sheng and Guangzhen Wu and the constructive effort to expand upon the translational potential of spatial transcriptomics in clear-cell renal cell carcinoma (ccRCC) detailed in our recent Review¹ (Lessons learned from spatial transcriptomic analyses in clear-cell renal cell carcinoma. <i>Nat. Rev. Urol</i>. https://doi.org/10.1038/s41585-024-00980-x; 2025)¹, which are valuable (Enhancing spatial transcriptomics in clear-cell renal cell carcinoma. <i>Nat. Rev. Urol</i>. https://doi.org/10.1038/s41585-025-01085-9; 2025)². We have taken the opportunity to respond to the points raised.</p><p>We agree that transcript and protein levels often diverge and that proteomic and metabolomic validation can strengthen the functional interpretation of transcriptomic data. However, we do want to highlight that, in the context of biomarker development, transcriptional patterns alone have shown predictive value^3,4,5,6 and in certain circumstances might be sufficient to delineate clinically relevant phenotypes without protein-level confirmation.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"18 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}