Nature Reviews Urology最新文献

Excluding PLND in favourable intermediate-risk prostate cancer: a PSMA-PET-directed perspective. 在有利的中危前列腺癌中排除PLND: psma - pet指导的观点。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-24 DOI: 10.1038/s41585-025-01105-8

David Song,Kamil Malshy,Edward M Messing,Jean V Joseph,Jathin Bandari

引用次数: 0

Clinical translation of polygenic scores for prostate cancer screening. 前列腺癌筛查多基因评分的临床翻译。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-13 DOI: 10.1038/s41585-025-01095-7

Dmitry Ratner,Jason L Vassy

引用次数: 0

A urologist as a urological patient. 作为泌尿科病人的泌尿科医生。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-13 DOI: 10.1038/s41585-025-01099-3

Henry H Woo

引用次数: 0

The hypoxic ECM and neutrophils in MIBC immunotherapy resistance. 缺氧ECM和中性粒细胞在MIBC免疫治疗耐药中的作用。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-13 DOI: 10.1038/s41585-025-01092-w

Fraser Child,Sapna Lunj,Julie Gough,Martin J Humphries,Luisa Vanesa Biolatti,Peter J Hoskin,Ananya Choudhury,Conrado Guerrero Quiles

{"title":"The hypoxic ECM and neutrophils in MIBC immunotherapy resistance.","authors":"Fraser Child,Sapna Lunj,Julie Gough,Martin J Humphries,Luisa Vanesa Biolatti,Peter J Hoskin,Ananya Choudhury,Conrado Guerrero Quiles","doi":"10.1038/s41585-025-01092-w","DOIUrl":"https://doi.org/10.1038/s41585-025-01092-w","url":null,"abstract":"Immune-checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD1) and programmed cell death 1 ligand 1 (PDL1) have improved survival for patients with different types of solid tumour. However, clinical response in patients with muscle-invasive bladder cancer (MIBC) is limited, with only 20-30% demonstrating a sustained response. An improved understanding of ICI mechanisms and robust biomarkers will increase efficacy and enable patient stratification in MIBC. Hypoxia (low oxygen tension) and neutrophil infiltration are prevalent in MIBC and are associated with immunotherapy resistance. Hypoxia-associated extracellular matrix (ECM) remodelling can induce pro-tumour or anti-tumour neutrophil polarization through biomechanical and biochemical signalling. Hypoxia-associated ECM mechanisms alter neutrophil recruitment, polarization, activation and affect T cell-centric immunotherapies. However, the specific mechanisms by which hypoxia, ECM and neutrophils confer immunotherapy resistance in MIBC are not yet fully understood. ICI resistance could be overcome by targeting specific ECM remodelling-related and neutrophil-related pathways to elicit durable and efficacious responses in 70-80% of patients with MIBC who are currently non-responsive to ICIs.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"7 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145283443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic targeting of prostate-specific membrane antigen could limit its potential as benchmark imaging. 前列腺特异性膜抗原的治疗靶向可能限制其作为基准成像的潜力。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-13 DOI: 10.1038/s41585-025-01100-z

Melissa L Abel,Adam Sharp,Edwin M Posadas,Fatima Karzai,Frank I Lin,Peter L Choyke,Ravi A Madan

引用次数: 0

Digital twins for personalized treatment in uro-oncology in the era of artificial intelligence. 人工智能时代泌尿肿瘤个性化治疗的数字双胞胎。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-10 DOI: 10.1038/s41585-025-01096-6

Magdalena Görtz,Carlos Brandl,Anna Nitschke,Anja Riediger,Daniel Stromer,Michael Byczkowski,Vincent Heuveline,Matthias Weidemüller

{"title":"Digital twins for personalized treatment in uro-oncology in the era of artificial intelligence.","authors":"Magdalena Görtz,Carlos Brandl,Anna Nitschke,Anja Riediger,Daniel Stromer,Michael Byczkowski,Vincent Heuveline,Matthias Weidemüller","doi":"10.1038/s41585-025-01096-6","DOIUrl":"https://doi.org/10.1038/s41585-025-01096-6","url":null,"abstract":"'Digital twins', also called 'digital patient twins' or 'virtual human twins' - digital patient-specific models derived from multimodal health data - are a strong focus in health care and are emerging as a promising tool for improving personalized care in uro-oncology. These models can integrate clinical, genomic, imaging and histopathological information to simulate organ behaviour and disease progress as well as predict responses to treatments. The concept of digital twins has shown potential in various fields, but its application in uro-oncology is still evolving, with few assessments of their feasibility and clinical utility. The advent of artificial intelligence adds a new dimension to their development, potentially enabling the synthesis of diverse, high-quality datasets to improve modelling accuracy and support real-time decision-making. However, substantial challenges exist, including data integration, patient privacy, computational demands and ethical frameworks. In addition, the interpretability of predictions remains essential for gaining clinical trust and guiding patient-centred decisions. The use of digital twins in uro-oncology has the potential to improve patient stratification and treatment planning; however, barriers must be overcome for their successful implementation in clinical routine. By integrating new technologies, fostering interdisciplinary collaboration and prioritizing transparency, digital twins could shape the future of precision uro-oncology.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"121 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on mechanisms and treatment options for priapism. 阴茎勃起障碍的机制和治疗方案的最新进展。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-08 DOI: 10.1038/s41585-025-01069-9

Karl H Pang,Hussain M Alnajjar,Alex Lal,Asif Muneer

{"title":"An update on mechanisms and treatment options for priapism.","authors":"Karl H Pang,Hussain M Alnajjar,Alex Lal,Asif Muneer","doi":"10.1038/s41585-025-01069-9","DOIUrl":"https://doi.org/10.1038/s41585-025-01069-9","url":null,"abstract":"Priapism is an abnormal prolonged penile erection that persists in the absence of any sexual stimulation. Priapism can be subcategorized into three types: ischaemic (low-flow or veno-occlusive), non-ischaemic (high-flow or arterial) and stuttering priapism. Ischaemic priapism is the most common subtype and is associated with multiple aetiologies, most commonly haemoglobinopathies and antipsychotic medications. The mechanisms underlying stuttering priapism are complex, and involve dysregulation of the nitric oxide signalling pathway, Rho-Rho kinase pathway, adenosine, opiorphins, oxidative stress and androgens. The investigation and management of priapism involve a stepwise approach. A clinical history, examination and a blood-gas analysis from the corpus cavernosum helps to distinguish between ischaemic and non-ischaemic subtypes. Colour Doppler ultrasonography and penile MRI can be used in more complex cases, or those with a delayed presentation. Treatment involves cavernosal blood aspiration followed by instillation of an α-adrenergic receptor agonist such as phenylephrine, proceeding to penile shunt surgery (within the first 24-48 h) if the priapism persists. Insertion of a penile prosthesis is indicated when a shunting procedure or penoscrotal decompression fails, or if a patient presents with a priapism persisting longer than 36-48 h depending on the guidelines used. For non-ischaemic priapism following failed conservative treatment, selective arterial embolization of the arteriocorporal fistula can be performed. The aetiology and pathophysiology of the different priapism subtypes help to determine the management of specific patients.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"1 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI for antibiotic design. 人工智能用于抗生素设计。

IF 14.6 1区医学

Nature Reviews Urology Pub Date : 2025-10-08 DOI: 10.1038/s41585-025-01102-x

Louise Lloyd

引用次数: 0

Man plus machine: large language models can augment medical student education. 人加机器：大型语言模型可以增强医学生的教育。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-10-08 DOI: 10.1038/s41585-025-01097-5

Mihir S Shah,Matthew Buck

引用次数: 0

Ultra-processed food affects male fertility parameters. 超加工食品影响男性生育参数。