Nature Reviews Urology最新文献

Targeting the tumour cell surface in advanced prostate cancer

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-04-01 DOI: 10.1038/s41585-025-01014-w

Cristina Boixareu, Tarek Taha, Varadha Balaji Venkadakrishnan, Johann de Bono, Himisha Beltran

{"title":"Targeting the tumour cell surface in advanced prostate cancer","authors":"Cristina Boixareu, Tarek Taha, Varadha Balaji Venkadakrishnan, Johann de Bono, Himisha Beltran","doi":"10.1038/s41585-025-01014-w","DOIUrl":"https://doi.org/10.1038/s41585-025-01014-w","url":null,"abstract":"Prostate cancer remains a substantial health challenge, with >375,000 annual deaths amongst men worldwide. Most prostate cancer-related deaths are attributable to the development of resistance to standard-of-care treatments. Characterization of the diverse and complex surfaceome of treatment-resistant prostate cancer, combined with advances in drug development that leverage cell-surface proteins to enhance drug delivery or activate the immune system, have provided novel therapeutic opportunities to target advanced prostate cancer. The prostate cancer surfaceome, including proteins such as prostate-specific membrane antigen (PSMA), B7-H3, six transmembrane epithelial antigen of the prostate 1 (STEAP1), delta-like ligand 3 (DLL3), trophoblastic cell-surface antigen 2 (TROP2), prostate stem cell antigen (PSCA), HER3, CD46 and CD36, can be exploited as therapeutic targets, as regulatory mechanisms might contribute to the heterogeneity of expression of these proteins and subsequently affect treatment response and resistance. Specific treatment strategies targeting the surfaceome are in clinical development, including radionuclides, antibody–drug conjugates, T cell engagers and chimeric antigen receptor (CAR) T cells. Ultimately, biomarker development and clinical implementation of these agents will be informed and refined by further understanding of the biology of various targets; the target specificity and sensitivity of different agents; and off-target and toxic effects associated with these agents. Understanding the dynamic nature of cell-surface targets and non-overlapping expression patterns might also lead to future combinational strategies.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"12 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjuvant personalized cancer vaccine: is this the end of metastatic kidney cancer

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-27 DOI: 10.1038/s41585-025-01018-6

Manuela Schmidinger, Irene Huebner-Resch

引用次数: 0

A bladder blueprint to build better models for understanding homeostasis and disease

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-26 DOI: 10.1038/s41585-025-01013-x

Léa G. Deltourbe, Méline Durand, Ariana Costas, Molly A. Ingersoll

{"title":"A bladder blueprint to build better models for understanding homeostasis and disease","authors":"Léa G. Deltourbe, Méline Durand, Ariana Costas, Molly A. Ingersoll","doi":"10.1038/s41585-025-01013-x","DOIUrl":"https://doi.org/10.1038/s41585-025-01013-x","url":null,"abstract":"The bladder is a complex organ that can be affected by various pathologies, such as cancer or infection. It has a specific tissue structure composed of many different cell types and layers, including urothelial and endothelial cells but also a muscle layer controlling stretch and contraction to void urine. The bladder has constitutive and induced immune responses to infection or damage and harbours a microbiome. Each of these features can be influenced by factors including age and biological sex, which makes modelling homeostasis and disease in the bladder complex and challenging. To model diseases that affect the bladder, mouse models are an invaluable tool to understand the bladder in situ. However, stark differences exist between mice and humans, and so mouse models of human disease have limitations. Thus, models that more closely approximate human physiology would be expected to contribute to improved understanding of bladder biology. As technology advances, improvements in model development and creation of 3D bladder structures are enabling scientists to recapitulate essential aspects of human bladder physiology to gain increased understanding of bladder homeostasis and diseases.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"29 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considering urology in a planetary context

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-18 DOI: 10.1038/s41585-025-01019-5

引用次数: 0

The role of the urinary microbiome in genitourinary cancers

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01011-z

Seoho Lee, Karen Sfanos, Nirmish Singla

{"title":"The role of the urinary microbiome in genitourinary cancers","authors":"Seoho Lee, Karen Sfanos, Nirmish Singla","doi":"10.1038/s41585-025-01011-z","DOIUrl":"https://doi.org/10.1038/s41585-025-01011-z","url":null,"abstract":"Genitourinary cancers account for 20% of cancer instances globally and pose a substantial burden. The microbiome, defined as the ecosystem of organisms that reside within and on the human body, seems to be closely related to multiple cancers. Research on the gut microbiome has yielded substantial insights into the interactions of this entity with the immune system and cancer therapeutic efficacy, whereas the urinary microbiome has been relatively less well-studied. Advances in next-generation sequencing technologies led to new discoveries in the urinary microbiome, which might aid in early detection, risk stratification and personalized treatment strategies in genitourinary cancers. Mechanistic investigations have also suggested a role for the urinary microbiome in modulating the tumour microenvironment and host immune response. For example, distinct urinary microbial signatures have been linked to bladder cancer occurrence and recurrence risk, with specific taxa associated with cytokine production and inflammation. Urinary microbiome signatures have also been explored as potential biomarkers for non-invasive cancer detection. However, challenges remain in standardizing methodologies, validating findings across studies, and establishing causative mechanisms. As investigations into the urinary microbiome continue to evolve, so does the potential for developing microbiome-modulating therapies and enhancing diagnostic capabilities to improve outcomes in patients with genitourinary cancers.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"54 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A complex association with cadmium 与镉的复杂联系

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01022-w

Annette Fenner

{"title":"A complex association with cadmium","authors":"Annette Fenner","doi":"10.1038/s41585-025-01022-w","DOIUrl":"https://doi.org/10.1038/s41585-025-01022-w","url":null,"abstract":"Cadmium is a heavy metal that is often found in water systems and soil owing to its release from industrial processes. Occupational exposure is seen in those who work in production and use of nickel–cadmium batteries, phosphate fertilizers, copper and nickel smelting, and waste incineration and disposal. Furthermore, exposure in the general population can occur via cigarette smoke, water and consumption of foods that accumulate cadmium. The long half-life of this metal means that it can accumulate in human tissue, leading to a variety of health concerns. The mechanisms and causes of overactive bladder (OAB) remain unclear, but the known neurotoxic and pro-inflammatory properties of cadmium mean it is considered a possible contributing factor.Data were analysed from the 2007–2020 National Health and Nutrition Examination Survey (NHANES), and the relationship between blood cadmium levels and OAB and its components were assessed using weighted multivariate logistic regression. Prevalence of OAB in this database was 26.2% of the 15,467 respondents. Blood cadmium levels were associated with overall OAB, but this association was small and not significant after adjusting for other variables, although blood cadmium levels in the OAB group were statistically higher than in the non-OAB group. Cadmium was inversely associated with severity of nocturia (OR 0.85, 95% CI 0.74–0.98, P < 0.05) and was also linked to more severe incontinence in adults aged 50–59 years and in non-Hispanic Black patients.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"32 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to ambient air pollution increases risk 暴露于环境空气污染会增加风险

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01021-x

Annette Fenner

引用次数: 0

Melon seed extract protects against testis metal toxicity 甜瓜种子提取物可防止睾丸金属中毒

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01020-y

Annette Fenner

{"title":"Melon seed extract protects against testis metal toxicity","authors":"Annette Fenner","doi":"10.1038/s41585-025-01020-y","DOIUrl":"https://doi.org/10.1038/s41585-025-01020-y","url":null,"abstract":"Overexpression of free radicals induced by heavy metals such as aluminium (Al) and nickel (Ni) can be detrimental to male fertility. However, by-products of agriculture, such as peels, seeds and leaves, are rich in bioactive compounds and might, therefore, be useful as potential protectors of reproductive health. Cucumeropsis mannii is a melon whose seed is rich in alkaloids, flavonoids, glycosides, steroids and tannins, the husk of which is burned and becomes incorporated into the soil in Nigeria, where the study was performed. In the same area, crude oil exploration results in high levels of Ni and Al pollution.In the study, male rats were exposed to Ni, Al or a binary mixture of the two (Ni/Al), which decreased serum gonadotrophins (LH and FSH) and testosterone (T) compared with controls. Co-administration with melon seed husk extract (MSHE) nanoparticles significantly increased FSH, LH and T compared with the metal-only exposed groups; this effect was also seen in rats receiving MSHE alone. Interestingly, prolactin was significantly increased in metal-treated animals, but co-treatment with MSHE reduced these levels and MSHE-only treatment significantly lowered prolactin below the level seen in the metal-treated groups.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"14 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorination by-products in drinking water — association with bladder cancer risk

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01017-7

Maria Chiara Masone

引用次数: 0

GSTA2 mitigates DEHP-induced reproductive toxic effects

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-03-12 DOI: 10.1038/s41585-025-01016-8

Maria Chiara Masone

引用次数: 0