Nature Reviews Urology最新文献

Endocrine-disrupting chemicals as prostate carcinogens 干扰内分泌的化学物质作为前列腺癌物

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-16 DOI: 10.1038/s41585-025-01031-9

Mariana Feijó, Tiago M. A. Carvalho, Lara R. S. Fonseca, Cátia V. Vaz, Bruno J. Pereira, José Eduardo B. Cavaco, Cláudio J. Maia, Ana P. Duarte, Endre Kiss-Toth, Sara Correia, Sílvia Socorro

{"title":"Endocrine-disrupting chemicals as prostate carcinogens","authors":"Mariana Feijó, Tiago M. A. Carvalho, Lara R. S. Fonseca, Cátia V. Vaz, Bruno J. Pereira, José Eduardo B. Cavaco, Cláudio J. Maia, Ana P. Duarte, Endre Kiss-Toth, Sara Correia, Sílvia Socorro","doi":"10.1038/s41585-025-01031-9","DOIUrl":"https://doi.org/10.1038/s41585-025-01031-9","url":null,"abstract":"Endocrine-disrupting chemicals (EDCs) are natural or synthetic compounds that are ubiquitous in the environment and in daily-usage products and interfere with the normal function of the endocrine system leading to adverse health effects in humans. Exposure to these chemicals might elevate the risk of metabolic disorders, developmental and reproductive defects, and endocrine-related cancers. Prostate cancer is the most common hormone-dependent cancer in men, and the fifth leading cause of cancer-related mortality, partly owing to a lack of knowledge about the mechanisms that lead to aggressive castration-resistant forms. In addition to the dependence of early-stage prostate cancer on androgen actions, the prostate is a target of oestrogenic regulation. This hormone dependence, along with the fact that exogenous influences are major risk factors for prostate cancer, make the prostate a likely target of harmful actions from EDCs. Various sources of EDCs and their different modes of action might explain their role in prostate carcinogenesis.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"18 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology and potential multimodal therapeutic strategies for IC/BPS. IC/BPS的病理生理学和潜在的多模式治疗策略。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-15 DOI: 10.1038/s41585-025-01044-4

Jia-Fong Jhang,Wan-Ru Yu,Yuan-Hong Jiang,Hann-Chorng Kuo

引用次数: 0

What happens in Vegas … shapes the future of urology 在维加斯发生的一切…塑造了泌尿外科的未来

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-15 DOI: 10.1038/s41585-025-01048-0

Maria Chiara Masone

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XYGO: proposing a new holistic measure of gender identity and sexual orientation. XYGO：提出一种新的性别认同和性取向的整体衡量标准。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-13 DOI: 10.1038/s41585-025-01041-7

Alexi Di Cristofaro,Tommaso B Jannini,Elena Colonnello,Erika Limoncin,Daniele Mollaioli,Giacomo Ciocca,Andrea Sansone,Emmanuele A Jannini

{"title":"XYGO: proposing a new holistic measure of gender identity and sexual orientation.","authors":"Alexi Di Cristofaro,Tommaso B Jannini,Elena Colonnello,Erika Limoncin,Daniele Mollaioli,Giacomo Ciocca,Andrea Sansone,Emmanuele A Jannini","doi":"10.1038/s41585-025-01041-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01041-7","url":null,"abstract":"Gender identity (GI) and sexual orientation (SO) are key aspects of an individual's sexual identity, which is a major driver of human sexuality. Although definitions for GI and SO have been long established and represented in clinical and theoretical research, often without acknowledgement of their relationship to one another, the ideal means by which they should be measured is unclear. Various tools for measurement have been proposed, each presenting different methodological approaches along with their respective flaws and issues. By providing a comprehensive overview of the major instruments for measuring GI and SO, the XYGO tool aims to integrate their strengths by developing a new, cohesive and inclusive perspective on sexual identity, taking into consideration both dimensions of this unique characteristic of human sexuality. This holistic perspective integrates these components into a single construct capable of providing a more immediate and tailored interpretation to facilitate everyday clinical practice and potentially improve research in sexual medicine and psychosexology.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"74 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testosterone replacement therapy and spermatogenesis in reproductive age men 睾酮替代疗法与育龄男性精子发生

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-09 DOI: 10.1038/s41585-025-01032-8

Bryan D. Naelitz, Leila Momtazi-Mar, Sanjay Vallabhaneni, Rossella Cannarella, Sarah C. Vij, Neel V. Parekh, Raevti Bole, Scott D. Lundy

{"title":"Testosterone replacement therapy and spermatogenesis in reproductive age men","authors":"Bryan D. Naelitz, Leila Momtazi-Mar, Sanjay Vallabhaneni, Rossella Cannarella, Sarah C. Vij, Neel V. Parekh, Raevti Bole, Scott D. Lundy","doi":"10.1038/s41585-025-01032-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01032-8","url":null,"abstract":"Testosterone has a pivotal role in spermatogenesis, erectile function, libido and expression of secondary sexual characteristics. The prevalence of symptomatic, laboratory-proven testosterone deficiency increases with age and is often treated with testosterone replacement therapy (TRT). Treatment with exogenous androgens suppresses gonadotropin levels, inhibits endogenous testosterone production and drastically reduces intratesticular testosterone, consequently impairing spermatogenesis. Sperm production often slowly resumes after TRT cessation. However, the rate of recovery shows highly variable kinetics that might complicate family planning. Medical therapies (including aromatase inhibitors and selective oestrogen receptor antagonists) and exogenous gonadotropins (including human chorionic gonadotropin and follicle-stimulating hormone) may be used to preserve or restore spermatogenesis in select populations receiving TRT. Exogenous testosterone is contraindicated in men trying to conceive, but new short-acting formulations, including oral testosterone undecanoate and nasal testosterone gel, might incompletely suppress the hypothalamic–pituitary–gonadal axis and partially preserve spermatogenesis.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"109 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The disruption of circadian rhythm as a potential mechanism of nocturia-like symptoms - a paediatric urology perspective. 昼夜节律的破坏作为夜尿症样症状的潜在机制-儿科泌尿学的观点。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-05-01 DOI: 10.1038/s41585-025-01024-8

María P Herrera, Cristina Dominguez

引用次数: 0

Disruption of circadian rhythm as a potential pathogenesis of nocturia. 昼夜节律紊乱是夜尿症的潜在发病机制。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-05-01 Epub Date: 2024-11-14 DOI: 10.1038/s41585-024-00961-0

Qi-Xiang Song, Sylvia O Suadicani, Hiromitsu Negoro, Hai-Hong Jiang, Rita Jabr, Christopher Fry, Wei Xue, Margot S Damaser

{"title":"Disruption of circadian rhythm as a potential pathogenesis of nocturia.","authors":"Qi-Xiang Song, Sylvia O Suadicani, Hiromitsu Negoro, Hai-Hong Jiang, Rita Jabr, Christopher Fry, Wei Xue, Margot S Damaser","doi":"10.1038/s41585-024-00961-0","DOIUrl":"10.1038/s41585-024-00961-0","url":null,"abstract":"Increasing evidence suggested the multifactorial nature of nocturia, but the true pathogenesis of this condition still remains to be elucidated. Contemporary clinical medications are mostly symptom based, aimed at either reducing nocturnal urine volume or targeting autonomic receptors within the bladder to facilitate urine storage. The day-night switch of the micturition pattern is controlled by circadian clocks located both in the central nervous system and in the peripheral organs. Arousal threshold and secretion of melatonin and vasopressin increase at night-time to achieve high-quality sleep and minimize nocturnal urine production. In response to the increased vasopressin, the kidney reduces the glomerular filtration rate and facilitates the reabsorption of water. Synchronously, in the bladder, circadian oscillation of crucial molecules occurs to reduce afferent sensory input and maintain sufficient bladder capacity during the night sleep period. Thus, nocturia might occur as a result of desynchronization in one or more of these circadian regulatory mechanisms. Disrupted rhythmicity of the central nervous system, kidney and bladder (known as the brain-kidney-bladder circadian axis) contributes to the pathogenesis of nocturia. Novel insights into the chronobiological nature of nocturia will be crucial to promote a revolutionary shift towards effective therapeutics targeting the realignment of the circadian rhythm.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":"276-293"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to 'The disruption of circadian rhythm as a potential mechanism of nocturia-like symptoms - a paediatric urology perspective'. 回复“昼夜节律的破坏是夜尿症样症状的潜在机制——儿科泌尿学观点”。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-05-01 DOI: 10.1038/s41585-025-01025-7

Qi-Xiang Song, Sylvia Suadicani, Hiromitsu Negoro, Hai-Hong Jiang, Rita Jabr, Christopher Fry, Wei Xue, Margot S Damaser

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Towards precision medicine in clinical trials for the treatment of urologic chronic pelvic pain syndrome: lessons from the MAPP Research Network 在泌尿系统慢性盆腔疼痛综合征的临床试验中走向精准医学：来自MAPP研究网络的经验教训

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-04-30 DOI: 10.1038/s41585-025-01030-w

Alisa J. Stephens Shields, J. Quentin Clemens, Michel A. Pontari, H. Henry Lai, Robert Moldwin, David A. Williams, Catherine S. Bradley, John T. Farrar, J. Richard Landis, Chris Mullins, Bruce D. Naliboff, Siobhan Sutcliffe, Stephen J. Walker, Claire C. Yang, Daniel J. Clauw

{"title":"Towards precision medicine in clinical trials for the treatment of urologic chronic pelvic pain syndrome: lessons from the MAPP Research Network","authors":"Alisa J. Stephens Shields, J. Quentin Clemens, Michel A. Pontari, H. Henry Lai, Robert Moldwin, David A. Williams, Catherine S. Bradley, John T. Farrar, J. Richard Landis, Chris Mullins, Bruce D. Naliboff, Siobhan Sutcliffe, Stephen J. Walker, Claire C. Yang, Daniel J. Clauw","doi":"10.1038/s41585-025-01030-w","DOIUrl":"https://doi.org/10.1038/s41585-025-01030-w","url":null,"abstract":"Randomized clinical trials have resulted in few approved therapies for the treatment of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively referred to as urologic chronic pelvic pain syndrome. Heterogenous patient populations, mismatches of treatments to patient phenotypes, non-specific outcomes and use of standard study designs not leveraging phenotypic heterogeneity might have contributed to the inability of previous trials to demonstrate existing efficacy. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network has identified important phenotypic characteristics associated with differential symptom severity and treatment responsiveness. Based on Multidisciplinary Approach to the Study of Chronic Pelvic Pain findings and external research, empirically informed strategies were generated for defining patient populations, specifying treatments and selecting primary outcomes for future randomized clinical trials in urologic chronic pelvic pain syndrome. Explicitly specifying the scope of eligibility criteria across heterogeneous patient subgroups defined by pain widespreadness, the presence of Hunner lesions, the presence of pain with bladder filling or relieved by voiding, the extent of chronic overlapping pain conditions, and pelvic floor tenderness is needed. Therapies should be selected based on the mechanism of action and relevance to the mechanism of pain and dominant symptomology that the patient experiences. Evidence suggests that pain and urinary symptoms should be evaluated separately. Promising trial designs for identifying effective therapies in this heterogeneous patient population include sequential multiple assignment randomized trials and adaptive designs.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"86 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconstructive urologists can address the care gap for adults with intersex traits 再造泌尿科医生可以解决有双性人特征的成年人的护理差距

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-04-29 DOI: 10.1038/s41585-025-01038-2

Maetal E. Haas Kogan, Barbara Chubak, Elizabeth R. Boskey, Steven J. Staffa, Carl G. Streed, Katharine B. Dalke, Arlene Baratz, Cecile Ferrando, Frances W. Grimstad

引用次数: 0