发布求助
文献互助 智能选刊 最新文献

Nature Reviews Urology最新文献

筛选
英文 中文
Understanding the roles of the WFDC cluster in sperm development and function 了解WFDC簇在精子发育和功能中的作用
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-17 DOI: 10.1038/s41585-025-00999-8
Annette Fenner
{"title":"Understanding the roles of the WFDC cluster in sperm development and function","authors":"Annette Fenner","doi":"10.1038/s41585-025-00999-8","DOIUrl":"https://doi.org/10.1038/s41585-025-00999-8","url":null,"abstract":"<p>A study in <i>Proceedings of the National Academy of Sciences</i> has elucidated the roles of the whey acidic protein four-disulfide core (WFDC) gene cluster in spermatogenesis and sperm function.</p><p>The fact that this reproductive-tract-specific cluster — comprising 11 genes in humans (<i>SPINT3</i>, <i>WFDC6</i>, <i>EPPIN</i>, <i>WFDC8</i>, <i>WFDC9</i>, <i>WFDC10A</i>, <i>WFDC11</i>, <i>WFDC10B</i>, <i>WFDC13</i>, <i>SPINT4</i> and <i>WFDC3)</i> and 13 in rodents — is so well conserved across species suggests combined critical functions of the cluster.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"5 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostate cancer epigenetics — from pathophysiology to clinical application 前列腺癌表观遗传学——从病理生理学到临床应用
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-024-00991-8
Vera Constâncio, João Lobo, José Pedro Sequeira, Rui Henrique, Carmen Jerónimo
{"title":"Prostate cancer epigenetics — from pathophysiology to clinical application","authors":"Vera Constâncio, João Lobo, José Pedro Sequeira, Rui Henrique, Carmen Jerónimo","doi":"10.1038/s41585-024-00991-8","DOIUrl":"https://doi.org/10.1038/s41585-024-00991-8","url":null,"abstract":"<p>Prostate cancer is a multifactorial disease influenced by various molecular features. Over the past decades, epigenetics, which is the study of changes in gene expression without altering the DNA sequence, has been recognized as a major driver of this disease. In the past 50 years, advancements in technological tools to characterize the epigenome have highlighted crucial roles of epigenetic mechanisms throughout the entire spectrum of prostate cancer, from initiation to progression, including localized disease, metastatic dissemination, castration resistance and neuroendocrine transdifferentiation. Substantial advances in the understanding of epigenetic mechanisms in the pathophysiology of prostate cancer have been carried out, but translating preclinical achievements into clinical practice remains challenging. Ongoing research and biomarker-oriented clinical trials are expected to increase the likelihood of successfully integrating epigenetics into prostate cancer clinical management.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"7 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A distinct TAM subset mediates immunotherapy resistance in prostate cancer 一个独特的TAM亚群介导前列腺癌的免疫治疗抵抗
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00996-x
Maria Chiara Masone
{"title":"A distinct TAM subset mediates immunotherapy resistance in prostate cancer","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-00996-x","DOIUrl":"https://doi.org/10.1038/s41585-025-00996-x","url":null,"abstract":"<p>Immune checkpoint inhibitor (ICI) efficacy in patients with metastatic castration-resistant prostate cancer (mCRPC) is hampered by resistance. Understanding the mechanisms underlying ICI resistance is crucial to improve therapeutic efficacy.</p><p>A new study published in <i>Nature</i> identified a distinct macrophage subset that shows increasing abundance as the disease progresses and that is responsible for immunotherapy resistance.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"13 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The burden of kidney transplant evaluation — an older adults’ perspective 肾移植负担评估——老年人视角
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00997-w
Maria Chiara Masone
{"title":"The burden of kidney transplant evaluation — an older adults’ perspective","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-00997-w","DOIUrl":"https://doi.org/10.1038/s41585-025-00997-w","url":null,"abstract":"<p>Kidney transplantation is a crucial treatment option for older adults (defined as ≥65 years old) with kidney failure, but the evaluation process for transplantation is often complex and burdensome, with many older adults not ultimately receiving a kidney.</p><p>In a study published in <i>JAMA Internal Medicine</i>, the authors explored the experiences of older adults and their families during the kidney transplant evaluation process. By using qualitative methods, including semi-structured interviews with 26 older adults and 7 family members, some dominant themes emerged, mostly related to the fact that the evaluation process is complex, lengthy and often leaves patients feeling responsible yet powerless about actively shaping this process.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"87 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Particulate matter leaves a bitter taste in testes 微粒物质在睾丸中留下苦涩的味道
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-01000-2
Louise Lloyd
{"title":"Particulate matter leaves a bitter taste in testes","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01000-2","DOIUrl":"https://doi.org/10.1038/s41585-025-01000-2","url":null,"abstract":"<p>New data show that bitter taste transduction has an essential role maintaining male reproductive health. This process is key in the inflammatory response to inhalable particulate matter and provides a mechanism by which exposure to particulate matter adversely affects male fertility. Bitter taste molecules could be potential targets for male infertility management.</p><p>A particulate matter exposure mouse model was established using intraperitoneal injection of ovalbumin (OVA) and subsequent aerosol inhalation of OVA. In OVA-exposed mice, testis weight, testis coefficient, seminiferous epithelium height, tubular diameter, number of maturing spermatids and Johnsen score were notably reduced and arrangement of spermatogenic cells was disordered. These effects were attenuated in mice who also received oral baicalin, a bitter compound.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"1 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of the Revi system in treating urgency urinary incontinence Revi系统治疗急迫性尿失禁的疗效观察
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00998-9
Maria Chiara Masone
{"title":"Efficacy of the Revi system in treating urgency urinary incontinence","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-00998-9","DOIUrl":"https://doi.org/10.1038/s41585-025-00998-9","url":null,"abstract":"<p>The 2-year follow-up results of the OASIS trial, assessing the efficacy of the novel implantable tibial neuromodulation device Revi in treating urgency urinary incontinence (UUI), were published in <i>The Journal of Urology</i>.</p><p>The Revi device is powered by an external, battery-operated wearable, which eliminates the need for an implanted battery, in turn providing more freedom margin for patients over other implantable devices, which are associated with high rates of reintervention also due to battery replacement.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"37 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Turning down the heat in NEPC 降低NEPC的热度
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00995-y
Louise Lloyd
{"title":"Turning down the heat in NEPC","authors":"Louise Lloyd","doi":"10.1038/s41585-025-00995-y","DOIUrl":"https://doi.org/10.1038/s41585-025-00995-y","url":null,"abstract":"<p>Heat shock protein 60 (HSP60), the main chaperone of the mitochondrial unfolded protein response, could be a potential therapeutic target in neuroendocrine prostate cancer (NEPC). Preclinical evidence shows that HSP60 inhibition reduces NEPC growth in vivo.</p><p>In the TRAMP mouse model, oxidative phosphorylation complex activity was dysfunctional in mitochondrial fractions from tumour samples. The mitochondrial unfolded protein response, assessed using HSP60 as a surrogate readout, was increased in several models of aggressive prostate cancer and patient sample datasets.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"68 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pain management in percutaneous nephrolithotomy — an approach rooted in pathophysiology 经皮肾镜取石术中的疼痛处理——一种基于病理生理学的方法
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-13 DOI: 10.1038/s41585-024-00973-w
Kelli Aibel, Robert Chang, Arinze J. Ochuba, Kevin Koo, Jared S. Winoker
{"title":"Pain management in percutaneous nephrolithotomy — an approach rooted in pathophysiology","authors":"Kelli Aibel, Robert Chang, Arinze J. Ochuba, Kevin Koo, Jared S. Winoker","doi":"10.1038/s41585-024-00973-w","DOIUrl":"https://doi.org/10.1038/s41585-024-00973-w","url":null,"abstract":"<p>Pain related to percutaneous nephrolithotomy (PCNL) is multifactorial and poorly elucidated. However, understanding the pathophysiology of pain can enable a practical approach to pain management, which can be tailored to each patient. A number of potential mechanisms underlie pain perception in PCNL, and these mechanisms can be leveraged at various points on the perioperative care pathway. These interventions provide opportunities for modulation of pain associated with PCNL but must take into account various technical, pharmacological and patient-related considerations. Technical considerations include the influence of percutaneous access, stone removal and drainage techniques. Pharmacological aspects include the use of various analgesics and anaesthesia approaches. Patient factors include consideration of the biopsychosocial model in pain experience to understand each individual’s response to pain. By understanding the contemporary evidence surrounding the physiology of postoperative pain and identifying tangible intervention points, we can seek to mitigate postoperative pain in patients undergoing PCNL.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"87 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lessons learned from spatial transcriptomic analyses in clear-cell renal cell carcinoma 透明细胞肾细胞癌空间转录组分析的经验教训
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-09 DOI: 10.1038/s41585-024-00980-x
Jesper Jespersen, Cecilie Lindgaard, Laura Iisager, Johanne Ahrenfeldt, Iben Lyskjær
{"title":"Lessons learned from spatial transcriptomic analyses in clear-cell renal cell carcinoma","authors":"Jesper Jespersen, Cecilie Lindgaard, Laura Iisager, Johanne Ahrenfeldt, Iben Lyskjær","doi":"10.1038/s41585-024-00980-x","DOIUrl":"https://doi.org/10.1038/s41585-024-00980-x","url":null,"abstract":"<p>Spatial transcriptomics has emerged as a powerful tool for discerning the heterogeneity of the tumour microenvironment across various cancers, including renal cell carcinoma (RCC). Spatial transcriptomics-based studies conducted in clear-cell RCC (the only RCC subtype studied using this technique to date) have given insights into spatial interactions within this disease. These insights include the role of epithelial-to-mesenchymal transitioning, revealing proximity-dependent interactions between tumour cells, fibroblasts, interleukin-2-expressing macrophages and hyalinized regions. Investigations into metabolic programmes have shown high transcriptional heterogeneity within tumours, with a tendency of increased metabolic activity towards the tumour centre. T cell infiltration has been shown to be independent of neoantigen burden, although T cell activity correlates with both metabolic states and various transcripts expressed by tumour cells, fibroblasts and monocytes. The role of tertiary lymphoid structures in both plasma cell maturation and their infiltration of the tumour has been shown through tracks of fibroblasts. Collectively, these findings indicate the potential of spatial transcriptomics to reveal predictive spatial features, supporting its promise in the development of biomarkers for clear-cell RCC management.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"9 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiological effects of hypoxia on testis function and spermatogenesis 低氧对睾丸功能和精子发生的病理生理影响
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-06 DOI: 10.1038/s41585-024-00969-6
Tessa Lord
{"title":"Pathophysiological effects of hypoxia on testis function and spermatogenesis","authors":"Tessa Lord","doi":"10.1038/s41585-024-00969-6","DOIUrl":"https://doi.org/10.1038/s41585-024-00969-6","url":null,"abstract":"<p>Multiple conditions can cause hypoxia in the testis, including exposure to high altitude, sleep apnoea, testicular torsion and varicocele. Varicocele accounts for up to 44% of instances of primary infertility, but the cumulative contribution of hypoxic conditions to male infertility is undefined. Results of controlled hypobaric hypoxia studies have demonstrated a substantial detrimental effect of short-term and long-term exposures on sperm; however, downstream effects on embryo development and offspring health are less well understood. Hypoxia can have direct and indirect effects on the molecular biology and biochemistry of germ cells, including changes to gene expression, metabolism, oxidative stress and to the endocrine environment. Hypoxia also has often-overlooked effects on the epididymis, such as altered composition and gene expression of epithelial cells, with knock-on effects on sperm maturation, including the capacity to acrosome react. Evidence from model species shows that paternal hypoxia exposure results in disrupted embryo development and transgenerational effects on male fertility and offspring physiology. Overall, hypoxia induces a complex, multifaceted subfertility phenotype that is reversible with resolution of the exposure, in part because of a resilient testis stem cell population that thrives in hypoxia. However, the potential for transgenerational effects deserves further exploration, particularly in considering the purported decline in sperm counts over the past 50 years.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"42 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信