Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi
{"title":"Assessing the effects of prostate cancer therapies on cardiovascular health","authors":"Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi","doi":"10.1038/s41585-025-01002-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01002-0","url":null,"abstract":"<p>Contemporary advances in prostate cancer treatments have markedly improved patient outcomes, yet concerns persist regarding the increased cardiovascular toxicity of prostate cancer treatments, which is multifaceted. Local therapies entail non-negligible cardiovascular risks. The effects of androgen deprivation therapy, which is pivotal in disease management, on cardiovascular health remains contentious, with gonadotropin-releasing hormone agonists and antagonists showing varying cardiovascular outcomes. Despite the ongoing controversy over the cardiovascular risks of gonadotropin-releasing hormone antagonists versus agonists, current evidence does not support favouring one over the other based solely on cardiovascular risk. Combination therapy with androgen receptor pathway inhibitors and androgen deprivation therapy shows additive cardiovascular risks, but robust comparative data are lacking. Chemotherapies such as docetaxel and cabazitaxel, along with emerging targeted therapies and radiopharmaceuticals, are associated with varied cardiovascular risks, necessitating personalized patient assessment. Clinicians should adhere to cardio-oncology guidelines when prescribing therapeutic agents, especially for patients with pre-existing cardiovascular conditions. Optimal monitoring and management strategies are essential to mitigate cardiovascular morbidity and mortality.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"15 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing perioperative care in MIBC: insights from NIAGARA","authors":"Stephan Brönimann, Shahrokh F. Shariat","doi":"10.1038/s41585-025-01009-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01009-7","url":null,"abstract":"The results of the NIAGARA trial have considerably advanced treatment for patients with muscle-invasive bladder cancer, establishing a new therapeutic standard for cisplatin-eligible patients. Future trials will help to answer remaining questions about perioperative treatment optimization.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"10 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Navigating burnout in healthcare: the price of care in an uncaring system","authors":"Zainab Noor, Shannon L. Wallace","doi":"10.1038/s41585-025-01006-w","DOIUrl":"https://doi.org/10.1038/s41585-025-01006-w","url":null,"abstract":"Burnout in healthcare is not merely a by-product of overwork, but a systemic issue driven by a culture of relentless productivity and insufficient support. Self-care practices such as exercise and mindfulness offer temporary relief, but do little to address the root causes of burnout embedded in the healthcare system. By promoting self-compassion and collaboration over competition, healthcare can move beyond burnout, restoring the ‘human being’ in every ‘human doing’ and creating a sustainable, supportive system for all.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"10 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bladder instillations of gentamicin to treat refractory recurrent urinary tract infection","authors":"Sachin Malde","doi":"10.1038/s41585-025-01010-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01010-0","url":null,"abstract":"Bladder instillation of gentamicin is safe and effective in treating recurrent urinary tract infection that has failed to resolve with current guideline-based treatments. It also reduces the rate of antimicrobial resistance.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"14 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing diversity barriers in prostate cancer clinical trials for equitable healthcare outcomes","authors":"Peter Lang, Matt Vassar","doi":"10.1038/s41585-025-01008-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01008-8","url":null,"abstract":"Prostate cancer is the most common cancer in men, yet disparities persist in screening, diagnosis and treatment among populations with low socioeconomic status. Minority groups face barriers to clinical trial inclusion including limited awareness and financial challenges. Promoting diversity in clinical trials is crucial for inclusivity, improving treatment efficacy and achieving equitable health outcomes in prostate cancer care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"16 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini
{"title":"Treatment strategies in human papillomavirus-related advanced penile cancer","authors":"Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini","doi":"10.1038/s41585-025-00994-z","DOIUrl":"https://doi.org/10.1038/s41585-025-00994-z","url":null,"abstract":"<p>Penile cancer is a rare neoplasm with heterogeneous prevalence influenced by risk factors such as smoking, poor hygiene and human papillomavirus (HPV) infection. Southern Africa, South America and Southeast Asia have the highest incidence of this disease. Penile squamous cell carcinomas (PSCCs) account for the majority of instances of penile cancer, with HPV-related carcinogenesis implicated in up to half of them. Increases in PSCC incidence in industrialized nations parallel the rising high-risk HPV infection rates, particularly HPV-16. Early-stage, localized PSCC is often manageable, but treatment options in advanced disease remain limited, with poor survival outcomes. Emerging evidence suggests that HPV-positive PSCC might exhibit unique therapeutic responses, including increased sensitivity to radiotherapy and chemotherapy, as has been observed in HPV-driven head and neck squamous cell carcinoma. Results of studies in HPV-positive PSCC demonstrate improved responses to chemoradiotherapy and immunotherapy, underscoring the potential for tailored treatments and de-escalation. Additionally, incorporating immunotherapy with radiotherapy in HPV-driven PSCC might provide greater oncological benefits than standard chemotherapy. These observations suggest that treatment strategies for HPV-positive PSCC might benefit from de-escalated chemoradiotherapy regimens or immunotherapy incorporation, potentially optimizing efficacy while minimizing toxic effects. Furthermore, biomarkers such as tumour mutational burden, programmed cell death ligand 1 expression, and genetic alterations could be crucial for predicting treatment response. Comprehensive biomarker assessment and accurate HPV status determination are essential for developing patient-tailored therapeutic strategies. These data provide evidence of the potential benefits of individualized approaches based on tumour biology and biomarker profiles.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"129 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bringing bi-paternal offspring a step closer","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01012-y","DOIUrl":"https://doi.org/10.1038/s41585-025-01012-y","url":null,"abstract":"<p>Bi-paternal mice that survived to adulthood have been successfully created, according to new research published in <i>Cell Stem Cell</i>. This advance has implications for reproductive and regenerative medicine.</p><p>Previously, the instability of genomic imprinting has limited the potential of embryonic stem cells to produce viable offspring. In this study, the authors used frameshift mutations, gene deletions and regulatory region edits to introduce 20 genetic modifications that affected hundreds of imprinting genes to address the most severe developmental defects observed in bi-paternal embryos.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"13 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An exploratory study of new predictive biomarkers of castration resistance","authors":"Annette Fenner","doi":"10.1038/s41585-025-01007-9","DOIUrl":"https://doi.org/10.1038/s41585-025-01007-9","url":null,"abstract":"<p>Data published in the <i>British Journal of Cancer</i> describe the identification and analysis of four biomarkers that could be used as a real-time prognostic tool for development of castration-resistant prostate cancer (CRPC).</p><p>No biomarkers are currently available to predict the onset of castration resistance. Identification of patients who are likely to stop responding to androgen deprivation therapy (ADT) would enable prompt cessation of this treatment and progression to other modalities.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"33 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GDF15 blockade can reduce immunotherapy resistance in urothelial cancer","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01005-x","DOIUrl":"https://doi.org/10.1038/s41585-025-01005-x","url":null,"abstract":"<p>A new study published in <i>Nature</i> reports results from the phase I/IIa study GDFATHER, showing synergistic effects of the neutralizing anti-GDF15 antibody visugromab in combination with the anti-PD1 antibody nivolumab in patients with urothelial cancer.</p><p>This trial builds on results in preclinical models showing that GDF15 blockade enhanced the efficacy of PD1-mediated immunotherapy, indicating the potential of anti-GDF15 antibodies in mitigating immunotherapy resistance.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"55 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The key to humanitarian urology: do not import the surgeon, create trained local surgical teams","authors":"J. Rubio-Briones, A. Gallioli","doi":"10.1038/s41585-025-01003-z","DOIUrl":"https://doi.org/10.1038/s41585-025-01003-z","url":null,"abstract":"Humanitarian surgical missions provide substantial benefits to the involved surgeon and to the recipient communities. These missions should be planned and executed with the final aim to train local teams to implement innovative or standard surgical techniques.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"31 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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