Nature Reviews Urology最新文献

iCAFs control chemoresistance icaf控制化学耐药

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-07-14 DOI: 10.1038/s41585-025-01068-w

Louise Lloyd

引用次数: 0

Non-human primates as a translational model for the study of male reproductive health 非人灵长类动物作为雄性生殖健康研究的翻译模型

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-07-07 DOI: 10.1038/s41585-025-01062-2

R. Clayton Edenfield, Jasper C. Bash, Lyndsey E. Shorey-Kendrick, Rahul J. D’Mello, Travis L. Rice-Stitt, Olivia L. Hagen, Jason A. Graham, Kyle E. Orwig, Charles A. Easley, Jason C. Hedges, Carol B. Hanna, Jamie O. Lo

{"title":"Non-human primates as a translational model for the study of male reproductive health","authors":"R. Clayton Edenfield, Jasper C. Bash, Lyndsey E. Shorey-Kendrick, Rahul J. D’Mello, Travis L. Rice-Stitt, Olivia L. Hagen, Jason A. Graham, Kyle E. Orwig, Charles A. Easley, Jason C. Hedges, Carol B. Hanna, Jamie O. Lo","doi":"10.1038/s41585-025-01062-2","DOIUrl":"https://doi.org/10.1038/s41585-025-01062-2","url":null,"abstract":"Male fertility is complex and influenced by genetic, hormonal, environmental and lifestyle factors. However, limitations to human studies necessitate the use of reliable preclinical models to better understand the underlying mechanisms of male fertility. Rhesus macaques (Macaca mulatta), with their close genetic and physiological similarities to humans, offer an invaluable model for male reproductive health studies. The suitability of rhesus macaques for studying male infertility is based on similarities in spermatogenesis, hormonal cycles and the way in which assisted reproductive technologies can be applied, and key differences and similarities between human and rhesus macaque sperm structure, function and cryopreservation techniques highlight the translational potential of findings derived from macaque models. Furthermore, insights into the epigenetic and proteomic characteristics of sperm in both species improve understanding of how these findings can help to advance clinical diagnostics, male contraception and fertility preservation and illuminate the regulatory omics of normal reproduction. Thus, the rhesus macaque model offers critical insights into male fertility and studies in this species could contribute to advances in therapies for male infertility.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"51 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and therapeutic landscape of non-clear cell renal carcinoma. 非透明细胞肾癌的分子和治疗前景。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-07-04 DOI: 10.1038/s41585-025-01056-0

Prerna R Nepali, Ahmed Eraky, Kennedy E Okhawere, Navneet Dogra, Reza Mehrazin, Ketan Badani, Natasha Kyprianou

{"title":"Molecular and therapeutic landscape of non-clear cell renal carcinoma.","authors":"Prerna R Nepali, Ahmed Eraky, Kennedy E Okhawere, Navneet Dogra, Reza Mehrazin, Ketan Badani, Natasha Kyprianou","doi":"10.1038/s41585-025-01056-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01056-0","url":null,"abstract":"Non-clear cell renal cell carcinomas (nccRCC) include diverse subtypes such as papillary, oncocytic and chromophobe, collecting duct, molecularly defined and other rare histological subtypes, each associated with unique clinical, pathological, genetic and molecular features as well as therapeutic challenges. Surgical resection remains the primary approach for the treatment of localized nccRCC but optimal outcomes depend on tumour stage and the patient's overall health. Clinically established treatment guidelines tailored for patients diagnosed with nccRCC are limited owing to the molecular and histological heterogeneity of nccRCC. Progress has been made in systemic therapy for metastatic disease but nccRCC treatment still poses challenges as patients experience variable treatment responses to immunotherapy, targeted therapies, chemotherapy and some combination strategies. Molecular biomarkers as well as established techniques, such as immunohistochemical and genetic analysis, have a crucial role in early detection, prognosis prediction and personalization of targeted therapies for nccRCC. The increasing identification of potential signatures and actionable molecular targets will aid in the clinical decision-making for patients diagnosed with these rare tumours towards optimization of the therapeutic response and treatment outcomes.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the human prostate at the cellular level 在细胞水平上绘制人类前列腺图谱

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-07-02 DOI: 10.1038/s41585-025-01057-z

Olivier Cussenot

引用次数: 0

Promise without practice — charting the path forward for bladder cancer biomarkers 没有实践的承诺-绘制膀胱癌生物标志物的前进道路

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-07-02 DOI: 10.1038/s41585-025-01064-0

Marie-Pier St-Laurent, Peter C. Black

引用次数: 0

Why women are not treated equally in healthcare and what can be done 为什么妇女在医疗保健中得不到平等对待？可以做些什么

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-25 DOI: 10.1038/s41585-025-01063-1

Rajvinder Khasriya, Harry Horsley

引用次数: 0

Updated favourable-histology Wilms tumour risk stratification: rationale for future Children’s Oncology Group clinical trials 最新的有利组织学Wilms肿瘤风险分层：未来儿童肿瘤组临床试验的基本原理

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-20 DOI: 10.1038/s41585-025-01055-1

Daniel J. Benedetti, Nicholas G. Cost, Peter F. Ehrlich, Nicholas Evageliou, Elizabeth Fialkowski, Lauren N. Parsons, Kelly L. Vallance, Lindsay A. Renfro, Andrew L. Hong, Jennifer H. Aldrink, Luke Pater, Arnold C. Paulino, Jesse K. Sandberg, Ethan A. Smith, Amy L. Treece, Jeffrey S. Dome, James I. Geller, Elizabeth A. Mullen

{"title":"Updated favourable-histology Wilms tumour risk stratification: rationale for future Children’s Oncology Group clinical trials","authors":"Daniel J. Benedetti, Nicholas G. Cost, Peter F. Ehrlich, Nicholas Evageliou, Elizabeth Fialkowski, Lauren N. Parsons, Kelly L. Vallance, Lindsay A. Renfro, Andrew L. Hong, Jennifer H. Aldrink, Luke Pater, Arnold C. Paulino, Jesse K. Sandberg, Ethan A. Smith, Amy L. Treece, Jeffrey S. Dome, James I. Geller, Elizabeth A. Mullen","doi":"10.1038/s41585-025-01055-1","DOIUrl":"https://doi.org/10.1038/s41585-025-01055-1","url":null,"abstract":"Patients with Wilms tumour have benefited from the results of decades of large collaborative clinical trials, leading to improved care. In the National Wilms Tumor Study Group and now Children’s Oncology Group (COG) trials, risk stratification evolved and expanded with each generation of studies and, therefore, ensuring that each patient receives the appropriate therapy has become increasingly complex. A new risk stratification system has been developed that forms the basis of the upcoming COG favourable-histology Wilms tumour (FHWT) study. Topics of diagnostic and prognostic uncertainty, such as the findings of tumour pulmonary emboli or extra-abdominal lymphadenopathy at diagnosis, will be integrated into the central review determination of staging of FHWT by committee consensus to facilitate clinical classification for therapeutic studies. Clear documentation of the elements of current risk stratification are of particular importance as refinement of the classification of patients with FHWT continues in an effort to optimize research, personalize treatment and provide an educational resource.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"2 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turning back time in the testes 让时间在睾丸中倒流

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-18 DOI: 10.1038/s41585-025-01060-4

Louise Lloyd

{"title":"Turning back time in the testes","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01060-4","DOIUrl":"https://doi.org/10.1038/s41585-025-01060-4","url":null,"abstract":"Leydig cells are particularly vulnerable to testis ageing, new preclinical data in Nature Communications have shown. The pivotal factor in this process is ketogenesis, impairment of which drives testicular ageing and enhancement ameliorates it. These observations have implications for men’s reproductive health.Histological and functional analyses of testes from young (2-month-old) and aged (24-month-old) mice showed considerable testicular ageing in aged mice. β-galactosidase — a marker of cellular senescence — staining revealed that senescence increased with age and was associated with Leydig cells. A Leydig cell senescence signature was discovered using single-cell RNA sequencing. Gene set enrichment analysis revealed that upregulated genes associated with increased age were related to inflammation and downregulated genes were related to metabolism. Specifically, differential gene expression analysis showed that Hmgcs2 — which encodes the rate-limiting enzyme for ketogenesis — was most substantially downregulated, and immunofluorescence revealed a considerable reduction in HMGCS2 expression in aged mice. Assessment of intratesticular ketone bodies showed that acetoacetic acid and β-hydroxybutyric acid concentrations were diminished in aged testes.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"26 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum computing in surgery and urology — taking a quantum leap 量子计算在外科和泌尿外科的应用——实现了巨大的飞跃

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-16 DOI: 10.1038/s41585-025-01058-y

Raghav Khanna, Nicholas Raison, Alejandro Granados, Sebastien Ourselin, Giorgio Gandaglia, Alberto Briganti, Francesco Montorsi, Prokar Dasgupta

引用次数: 0

Pivotal role of PPARγ in UTO PPARγ在UTO中的关键作用

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-16 DOI: 10.1038/s41585-025-01061-3

Louise Lloyd

引用次数: 0