Nature Reviews Urology最新文献

Translating the m6A epitranscriptome for prostate cancer 翻译前列腺癌的m6A表转录组

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-09 DOI: 10.1038/s41585-025-01054-2

Qian Tao, Qian Zhang

引用次数: 0

Unlocking the power of semen analysis in primary health care — a path to men’s health and lifestyle transformation 释放精液分析在初级卫生保健中的力量——通往男性健康和生活方式转变的途径

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-06 DOI: 10.1038/s41585-025-01047-1

Hannah E. Lyons, Andrew Peel, Macarena Gonzalez, Josh Deluao, Oluwabunmi Olatunji, Victoria Nikitaras, Nicole O. McPherson

{"title":"Unlocking the power of semen analysis in primary health care — a path to men’s health and lifestyle transformation","authors":"Hannah E. Lyons, Andrew Peel, Macarena Gonzalez, Josh Deluao, Oluwabunmi Olatunji, Victoria Nikitaras, Nicole O. McPherson","doi":"10.1038/s41585-025-01047-1","DOIUrl":"https://doi.org/10.1038/s41585-025-01047-1","url":null,"abstract":"Declining fertility, overlooked mental health, and reduced life expectancy underscore the urgent need for renewed attention to men’s health. A semen analysis, traditionally used to assess fertility, holds untapped potential as a tool for promoting lifestyle changes and preventing chronic diseases in men. Spermatogenesis is highly sensitive to environmental and lifestyle factors and can be an early indicator of overall health. Disruptions in this process can signal underlying systemic issues and predict long-term health risks, including cardiovascular disease and metabolic disorders. An increasing number of men seek to engage in preconception care, as fertility is closely tied to a man’s sense of masculinity, identity and aspirations for fatherhood. In this context, a semen analysis can be a powerful motivator to encourage healthy behaviours and proactive health management. By incorporating semen analysis into primary care, health care providers can leverage men’s desire for fatherhood as an entry point to discuss broader health concerns, such as mental well-being, nutrition and physical activity. This approach would address immediate reproductive health, and also promote long-term wellness, helping to reduce the burden of chronic disease in men.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"10 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial dysfunction as a crucial mediator of ADT-induced cardiovascular risk 线粒体功能障碍是adt诱导心血管风险的重要中介

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-05 DOI: 10.1038/s41585-025-01050-6

Yu-Hsiang Lin, Kuo-Jen Lin, Horng-Heng Juang

{"title":"Mitochondrial dysfunction as a crucial mediator of ADT-induced cardiovascular risk","authors":"Yu-Hsiang Lin, Kuo-Jen Lin, Horng-Heng Juang","doi":"10.1038/s41585-025-01050-6","DOIUrl":"https://doi.org/10.1038/s41585-025-01050-6","url":null,"abstract":"We read with great interest the recent Review article by Tisseverasinghe et al.1, which offers a comprehensive overview of cardiovascular risks associated with various prostate cancer therapies, including androgen deprivation therapy (ADT) (Assessing the effects of prostate cancer therapies on cardiovascular health. Nat. Rev. Urol. https://doi.org/10.1038/s41585-025-01002-0; 2025). We wish to highlight an additional perspective, according to which mitochondrial dysfunction is likely to be a central mechanism bridging ADT to the diverse cardiometabolic sequelae.Accumulating evidence indicates that low testosterone levels induce oxidative stress and impair mitochondrial function2. Mitochondria, the cell’s powerhouse, regulate ATP production, redox balance and apoptosis. Perturbations in these processes during testosterone suppression might explain the heightened risk of atherosclerosis, QT prolongation and heart failure in men receiving ADT3,4. Indeed, cardiomyocytes are known to depend heavily on efficient mitochondrial ATP synthesis, and even subtle mitochondrial impairment can precipitate electrical instability (leading to arrhythmias) and structural remodelling (promoting cardiomyopathies)4.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"7 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to ‘Mitochondrial dysfunction as a crucial mediator of ADT-induced cardiovascular risk’ 回复“线粒体功能障碍是adt诱导心血管风险的关键中介”

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-06-05 DOI: 10.1038/s41585-025-01049-z

Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi

{"title":"Reply to ‘Mitochondrial dysfunction as a crucial mediator of ADT-induced cardiovascular risk’","authors":"Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi","doi":"10.1038/s41585-025-01049-z","DOIUrl":"https://doi.org/10.1038/s41585-025-01049-z","url":null,"abstract":"We appreciate the thoughtful comments from Yu-Hsiang Lin et al. regarding our Review article (Assessing the effects of prostate cancer therapies on cardiovascular health. Nat. Rev. Urol. https://doi.org/10.1038/s41585-025-01002-0; 2025)1. In their Correspondence (Mitochondrial dysfunction as a crucial mediator of ADT-induced cardiovascular risk. Nat. Rev. Urol. https://doi.org/10.1038/s41585-025-01050-6; 2025)2, the authors highlight the potential role of mitochondrial dysfunction as a unifying mechanism underlying the diverse systemic effects of androgen deprivation therapy (ADT), including cardiovascular, metabolic and neurocognitive complications.We agree that mitochondrial dysfunction is indeed a possible understudied contributor to ADT-induced cardiotoxicity. As Lin et al. note, low testosterone levels have been linked to oxidative stress and impaired mitochondrial function, which could contribute to conditions such as atherosclerosis, arrhythmias and heart failure3,4. These observations are further supported by preclinical and clinical evidence suggesting that ADT disrupts processes heavily reliant on mitochondrial integrity, including cellular energy metabolism, redox balance and apoptosis pathways5,6. Beyond cardiovascular effects, we also agree that mitochondrial dysfunction might potentially have a role in the progression of castration-resistant prostate cancer and ADT-associated neurocognitive decline. The observed shift towards aerobic glycolysis, often referred to as the Warburg effect, in prostate cancer cells under ADT might suggest a possible role for mitochondrial regulation in both oncogenesis and treatment resistance7.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"39 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular imaging of renal cell carcinomas: ready for prime time. 肾细胞癌的分子成像：准备就绪。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-06-01 Epub Date: 2024-11-14 DOI: 10.1038/s41585-024-00962-z

Qianyun Wu, Hongda Shao, Wei Zhai, Gang Huang, Jianjun Liu, Jeremie Calais, Weijun Wei

引用次数: 0

Effects of degradation-associated polypropylene particles in the surrounding tissue after surgical mesh implantation 手术补片植入后周围组织中降解相关聚丙烯颗粒的影响

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-23 DOI: 10.1038/s41585-025-01046-2

Nicholas T. H. Farr, Pascal Achenbach, Karl-Dietrich Sievert

引用次数: 0

Telesurgery in urology - advances, challenges and future directions. 泌尿外科远程手术的进展、挑战和未来方向。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-22 DOI: 10.1038/s41585-025-01045-3

Andrea Gallioli,Francesco Di Bello,Alberto Breda

引用次数: 0

Pride, not prejudice 骄傲，而不是偏见

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-21 DOI: 10.1038/s41585-025-01053-3

引用次数: 0

Pronouns in English: a user's guide. 英语代词：使用指南。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-20 DOI: 10.1038/s41585-025-01043-5

Rachel Oliver,Stephanie Lynnette,Tristan Brown,Tina Rashid

引用次数: 0

Synergistic targeting strategies for prostate cancer. 前列腺癌的协同靶向策略。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-05-20 DOI: 10.1038/s41585-025-01042-6

Xuanji Li,Zeyu Han,Jianzhong Ai

{"title":"Synergistic targeting strategies for prostate cancer.","authors":"Xuanji Li,Zeyu Han,Jianzhong Ai","doi":"10.1038/s41585-025-01042-6","DOIUrl":"https://doi.org/10.1038/s41585-025-01042-6","url":null,"abstract":"Prostate cancer is the second most commonly diagnosed cancer and the fifth leading cause of death among men worldwide. Androgen deprivation therapy is a common prostate cancer treatment, but its efficacy is often hindered by the development of resistance, which results in reducing survival benefits. Immunotherapy showed great promise in treating solid tumours; however, clinically significant improvements have not been demonstrated for patients with prostate cancer, highlighting specific drawbacks of this therapeutic modality. Hence, exploring novel strategies to synergistically enhance the efficacy of prostate cancer immunotherapy is imperative. Clinical investigations have focused on the combined use of targeted or gene therapy and immunotherapy for prostate cancer. Notably, tumour-specific antigens and inflammatory mediators are released from tumour cells after targeted or gene therapy, and the recruitment and infiltration of immune cells, including CD8+ T cells and natural killer cells activated by immunotherapy, are further augmented, markedly improving the efficacy and prognosis of prostate cancer. Thus, immunotherapy, targeted therapy and gene therapy could have reciprocal synergistic effects in prostate cancer in combination, resulting in a proposed synergistic model encompassing these three therapeutic modalities, presenting novel potential treatment strategies for prostate cancer.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"88 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0