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PEACEing together prostate cancer therapy 和平共处前列腺癌治疗
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00982-9
Louise Lloyd
{"title":"PEACEing together prostate cancer therapy","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00982-9","DOIUrl":"10.1038/s41585-024-00982-9","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"4-4"},"PeriodicalIF":12.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAK–STAT signalling and prostate basal cell fate JAK-STAT信号与前列腺基底细胞的命运
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00983-8
Louise Lloyd
{"title":"JAK–STAT signalling and prostate basal cell fate","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00983-8","DOIUrl":"10.1038/s41585-024-00983-8","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"4-4"},"PeriodicalIF":12.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Better PrEParation for HIV prevention in minority groups 加强对少数群体艾滋病毒预防的准备
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00981-w
Louise Lloyd
{"title":"Better PrEParation for HIV prevention in minority groups","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00981-w","DOIUrl":"10.1038/s41585-024-00981-w","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"4-4"},"PeriodicalIF":12.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robot-assisted radical prostatectomy haemostasis techniques and outcomes 机器人辅助根治性前列腺切除术止血技术及结果
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-12-05 DOI: 10.1038/s41585-024-00978-5
Gal Wald, Joshua Winograd, Mark Farha, Vanessa Dudley, Jim C. Hu
{"title":"Robot-assisted radical prostatectomy haemostasis techniques and outcomes","authors":"Gal Wald, Joshua Winograd, Mark Farha, Vanessa Dudley, Jim C. Hu","doi":"10.1038/s41585-024-00978-5","DOIUrl":"https://doi.org/10.1038/s41585-024-00978-5","url":null,"abstract":"The robot-assisted approach to radical prostatectomy has enabled same-day discharge. A substantial concern associated with this practice could be haemorrhage, but sound and thorough robot-assisted radical prostatectomy haemostasis surgical techniques that were introduced to prevent bleeding mitigate this phenomenon.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"16 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing the state of the art in congenital obstructive uropathy 推进先天性梗阻性尿路病变的最新进展
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00976-7
Ashley R. Jackson, Nathalia G. Amado, Nina Mann, Joost P. Schanstra, Rodrigo Ruano, Tahagod Mohamed, Richard S. Lee, Armando Lorenzo, Daryl McLeod, Brian Becknell
{"title":"Advancing the state of the art in congenital obstructive uropathy","authors":"Ashley R. Jackson, Nathalia G. Amado, Nina Mann, Joost P. Schanstra, Rodrigo Ruano, Tahagod Mohamed, Richard S. Lee, Armando Lorenzo, Daryl McLeod, Brian Becknell","doi":"10.1038/s41585-024-00976-7","DOIUrl":"https://doi.org/10.1038/s41585-024-00976-7","url":null,"abstract":"In March 2024, we convened a symposium to consider the state of the art regarding the mechanisms and management of congenital obstructive uropathy caused by bladder outlet obstruction, at which overarching themes emerged and opportunities for research were discussed to fill key knowledge gaps in achieving the best future for children with congenital obstructive uropathy.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"27 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time is on our side — rethinking the concept of time to treatment for prostate cancer 时间站在我们这一边——重新思考前列腺癌治疗的时间概念
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00977-6
Nynikka R. Palmer, Peter R. Carroll, Samuel L. Washington
{"title":"Time is on our side — rethinking the concept of time to treatment for prostate cancer","authors":"Nynikka R. Palmer, Peter R. Carroll, Samuel L. Washington","doi":"10.1038/s41585-024-00977-6","DOIUrl":"https://doi.org/10.1038/s41585-024-00977-6","url":null,"abstract":"Prostate cancer is often an indolent disease, and delays in treatment up to 6 months do not seem to affect cancer-free survival. Inadequate pre-treatment assessment and uninformed shared decision-making can lead to decision regret and disparities in receipt of treatments. Time is on our side to allocate sufficient time and resources to consider the most appropriate and individualized treatment decision in prostate cancer care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"26 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opening up about cancer and mental health 畅谈癌症和心理健康
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-11-27 DOI: 10.1038/s41585-024-00975-8
Anna Schueth
{"title":"Opening up about cancer and mental health","authors":"Anna Schueth","doi":"10.1038/s41585-024-00975-8","DOIUrl":"10.1038/s41585-024-00975-8","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"194-195"},"PeriodicalIF":12.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastasis development in non-muscle-invasive bladder cancer 非肌层浸润性膀胱癌的转移发展
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-20 DOI: 10.1038/s41585-024-00963-y
Michael Leyderman, Thenappan Chandrasekar, Petros Grivas, Roger Li, Seetharam Bhat, Alina Basnet, Oleg Shapiro, Joseph Jacob, Michael A. Daneshvar, Eyal Kord, Gennady Bratslavsky, Hanan Goldberg
{"title":"Metastasis development in non-muscle-invasive bladder cancer","authors":"Michael Leyderman, Thenappan Chandrasekar, Petros Grivas, Roger Li, Seetharam Bhat, Alina Basnet, Oleg Shapiro, Joseph Jacob, Michael A. Daneshvar, Eyal Kord, Gennady Bratslavsky, Hanan Goldberg","doi":"10.1038/s41585-024-00963-y","DOIUrl":"https://doi.org/10.1038/s41585-024-00963-y","url":null,"abstract":"<p>Non-muscle-invasive bladder cancer (NMIBC) is the most common type of bladder cancer presentation and is characterized by a varying probability of recurrence and progression. Sporadically, patients with NMIBC might also develop tumour metastases without any pathological evidence of muscle-invasive disease within the bladder, a condition known as metastatic NMIBC. In the published literature, this phenomenon is limited to several case reports and small reviews, with few data regarding the possible aetiologies. Several possible factors can be potentially associated with metastatic NMIBC, including tumour understaging, the number of transurethral resection procedures received by the patient, the presence of circulating tumour cells, the modality used for diagnostic cystoscopy and possible gender-associated differences. In this Perspective, our aim was to integrate and report currently available data on this relatively rare entity and provide some potential aetiological explanations.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"14 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tomorrow’s patient management: LLMs empowered by external tools 未来的病人管理：借助外部工具增强法学硕士的能力
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-20 DOI: 10.1038/s41585-024-00965-w
Kelvin Szolnoky, Tobias Nordström, Martin Eklund
{"title":"Tomorrow’s patient management: LLMs empowered by external tools","authors":"Kelvin Szolnoky, Tobias Nordström, Martin Eklund","doi":"10.1038/s41585-024-00965-w","DOIUrl":"https://doi.org/10.1038/s41585-024-00965-w","url":null,"abstract":"Large language models are gaining increasing interest in the medical community; however, an important but overlooked aspect of their capacity is their ability to integrate with tools. This integration greatly extends their potential application in health care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"197 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HSD3B1, prostate cancer mortality and modifiable outcomes HSD3B1、前列腺癌死亡率和可改变的结果
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-14 DOI: 10.1038/s41585-024-00953-0
Pedro F. S. Freitas, Alireza Abdshah, Rana R. McKay, Nima Sharifi
{"title":"HSD3B1, prostate cancer mortality and modifiable outcomes","authors":"Pedro F. S. Freitas, Alireza Abdshah, Rana R. McKay, Nima Sharifi","doi":"10.1038/s41585-024-00953-0","DOIUrl":"https://doi.org/10.1038/s41585-024-00953-0","url":null,"abstract":"<p>Androgen receptor stimulation by testosterone and dihydrotestosterone is crucial for prostate cancer progression. Despite the initial effectiveness of androgen deprivation therapy (ADT), castration-resistant prostate cancer eventually develops in most men. A common germline missense-encoding polymorphism in <i>HSD3B1</i> increases extra-gonadal androgen biosynthesis from adrenal precursors owing to increased availability of the encoded enzyme 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) — hence, it is called the adrenal-permissive enzyme. This mechanism explains the more rapid progression to castration-resistant prostate cancer in men who inherit this allele than in men without it via sustained androgen receptor activation despite ADT. Multiple clinical studies, including data derived from prospective phase III studies, have linked adrenal-permissive allele inheritance to inferior clinical responses to ADT and increased mortality, but reversal is possible with upfront adrenal androgen blockade. The adrenal-permissive allele exhibits divergent frequencies across various groups worldwide, which could contribute to differences in clinical outcomes among these populations. Large-scale data from the Million Veteran Program have shown homozygous <i>HSD3B1</i> adrenal-permissive allele inheritance to be an independent biomarker of prostate cancer-specific mortality. Together, these observations support the integration of <i>HSD3B1</i> into germline testing and clinical trials as it might help to identify groups at increased likelihood of benefiting from early, intensified, AR-targeting interventions. Lastly, 3βHSD1 is a promising target for pharmacological inhibition, which enables new strategies for systemic prostate cancer therapy.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"72 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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