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Promise without practice — charting the path forward for bladder cancer biomarkers 没有实践的承诺-绘制膀胱癌生物标志物的前进道路
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-07-02 DOI: 10.1038/s41585-025-01064-0
Marie-Pier St-Laurent, Peter C. Black
{"title":"Promise without practice — charting the path forward for bladder cancer biomarkers","authors":"Marie-Pier St-Laurent, Peter C. Black","doi":"10.1038/s41585-025-01064-0","DOIUrl":"10.1038/s41585-025-01064-0","url":null,"abstract":"Bladder cancer is a biologically heterogeneous disease, and ongoing efforts in biomarker research aim to support personalized treatment approaches. Circulating tumour DNA is approaching clinical integration through prospective trials, whereas other markers remain investigational owing to technical limitations, inconsistent findings and lack of validation. Rigorous biomarker-driven trials and cost-effectiveness studies are needed to enable the integration of molecular tools into routine practice. Biomarkers might ultimately lead to rational treatment de-escalation or escalation, improving outcomes while minimizing harm and cost.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"23 3","pages":"149-150"},"PeriodicalIF":14.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why women are not treated equally in healthcare and what can be done 为什么妇女在医疗保健中得不到平等对待？可以做些什么
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-25 DOI: 10.1038/s41585-025-01063-1
Rajvinder Khasriya, Harry Horsley
{"title":"Why women are not treated equally in healthcare and what can be done","authors":"Rajvinder Khasriya, Harry Horsley","doi":"10.1038/s41585-025-01063-1","DOIUrl":"10.1038/s41585-025-01063-1","url":null,"abstract":"Despite recognized sex-based differences in healthcare requirements, women continue to experience substantial disparities in treatment, diagnosis and research. This ‘gender health gap’ manifests through increased emergency wait times, dismissal of symptoms and inadequate research prioritization. Patient advocacy groups have emerged as powerful forces for change, successfully lobbying governments and raising awareness through social media. Addressing these disparities requires increased research funding, sex-specific study designs, improved medical education curricula and continued patient advocacy.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"23 2","pages":"65-67"},"PeriodicalIF":14.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updated favourable-histology Wilms tumour risk stratification: rationale for future Children’s Oncology Group clinical trials 最新的有利组织学Wilms肿瘤风险分层：未来儿童肿瘤组临床试验的基本原理
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-20 DOI: 10.1038/s41585-025-01055-1
Daniel J. Benedetti, Nicholas G. Cost, Peter F. Ehrlich, Nicholas Evageliou, Elizabeth Fialkowski, Lauren N. Parsons, Kelly L. Vallance, Lindsay A. Renfro, Andrew L. Hong, Jennifer H. Aldrink, Luke Pater, Arnold C. Paulino, Jesse K. Sandberg, Ethan A. Smith, Amy L. Treece, Jeffrey S. Dome, James I. Geller, Elizabeth A. Mullen
{"title":"Updated favourable-histology Wilms tumour risk stratification: rationale for future Children’s Oncology Group clinical trials","authors":"Daniel J. Benedetti, Nicholas G. Cost, Peter F. Ehrlich, Nicholas Evageliou, Elizabeth Fialkowski, Lauren N. Parsons, Kelly L. Vallance, Lindsay A. Renfro, Andrew L. Hong, Jennifer H. Aldrink, Luke Pater, Arnold C. Paulino, Jesse K. Sandberg, Ethan A. Smith, Amy L. Treece, Jeffrey S. Dome, James I. Geller, Elizabeth A. Mullen","doi":"10.1038/s41585-025-01055-1","DOIUrl":"10.1038/s41585-025-01055-1","url":null,"abstract":"Patients with Wilms tumour have benefited from the results of decades of large collaborative clinical trials, leading to improved care. In the National Wilms Tumor Study Group and now Children’s Oncology Group (COG) trials, risk stratification evolved and expanded with each generation of studies and, therefore, ensuring that each patient receives the appropriate therapy has become increasingly complex. A new risk stratification system has been developed that forms the basis of the upcoming COG favourable-histology Wilms tumour (FHWT) study. Topics of diagnostic and prognostic uncertainty, such as the findings of tumour pulmonary emboli or extra-abdominal lymphadenopathy at diagnosis, will be integrated into the central review determination of staging of FHWT by committee consensus to facilitate clinical classification for therapeutic studies. Clear documentation of the elements of current risk stratification are of particular importance as refinement of the classification of patients with FHWT continues in an effort to optimize research, personalize treatment and provide an educational resource. In this Consensus Statement, the authors describe the details of the evolution of the risk-based treatment of favourable-histology Wilms tumour (FHWT) and outline the rationale for the new risk stratification that will be used in the now open Children’s Oncology Group therapeutic trial for FHWT, AREN2231.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 11","pages":"775-788"},"PeriodicalIF":14.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41585-025-01055-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Turning back time in the testes 让时间在睾丸中倒流
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-18 DOI: 10.1038/s41585-025-01060-4
Louise Lloyd
{"title":"Turning back time in the testes","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01060-4","DOIUrl":"10.1038/s41585-025-01060-4","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 7","pages":"409-409"},"PeriodicalIF":14.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum computing in surgery and urology — taking a quantum leap 量子计算在外科和泌尿外科的应用——实现了巨大的飞跃
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-16 DOI: 10.1038/s41585-025-01058-y
Raghav Khanna, Nicholas Raison, Alejandro Granados, Sebastien Ourselin, Giorgio Gandaglia, Alberto Briganti, Francesco Montorsi, Prokar Dasgupta
{"title":"Quantum computing in surgery and urology — taking a quantum leap","authors":"Raghav Khanna, Nicholas Raison, Alejandro Granados, Sebastien Ourselin, Giorgio Gandaglia, Alberto Briganti, Francesco Montorsi, Prokar Dasgupta","doi":"10.1038/s41585-025-01058-y","DOIUrl":"10.1038/s41585-025-01058-y","url":null,"abstract":"Quantum computing can revolutionize surgery by accelerating the training of artificial intelligence models on large, diverse datasets, advancing robotic autonomy and facilitating a detailed study of biological structures and materials on a very minute scale. Substantial technical, financial and regulatory challenges must be overcome for the successful implementation of quantum computing in urology.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"23 1","pages":"2-3"},"PeriodicalIF":14.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pivotal role of PPARγ in UTO PPARγ在UTO中的关键作用
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-16 DOI: 10.1038/s41585-025-01061-3
Louise Lloyd
{"title":"Pivotal role of PPARγ in UTO","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01061-3","DOIUrl":"10.1038/s41585-025-01061-3","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 7","pages":"409-409"},"PeriodicalIF":14.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture to reduce nocturia in survivors of prostate cancer 针灸减少前列腺癌幸存者夜尿症
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-16 DOI: 10.1038/s41585-025-01059-x
Maria Chiara Masone
{"title":"Acupuncture to reduce nocturia in survivors of prostate cancer","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01059-x","DOIUrl":"10.1038/s41585-025-01059-x","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 7","pages":"409-409"},"PeriodicalIF":14.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translating the m6A epitranscriptome for prostate cancer 翻译前列腺癌的m6A表转录组
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-09 DOI: 10.1038/s41585-025-01054-2
Qian Tao  (, ), Qian Zhang  (, )
{"title":"Translating the m6A epitranscriptome for prostate cancer","authors":"Qian Tao \u0000 (, ), Qian Zhang \u0000 (, )","doi":"10.1038/s41585-025-01054-2","DOIUrl":"10.1038/s41585-025-01054-2","url":null,"abstract":"Mapping the N6-methyladenosine (m6A) transcriptome in prostate cancer has established its clinical potential value as a prognostic biomarker for this disease. A multidisciplinary approach that integrates genomics, transcriptomics, epitranscriptomics, proteomics and clinical oncology is essential to translate the intricacies of m6A modification into tangible benefits for patients","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 12","pages":"797-798"},"PeriodicalIF":14.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144238137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the power of semen analysis in primary health care — a path to men’s health and lifestyle transformation 释放精液分析在初级卫生保健中的力量——通往男性健康和生活方式转变的途径
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-06 DOI: 10.1038/s41585-025-01047-1
Hannah E. Lyons, Andrew Peel, Macarena Gonzalez, Josh Deluao, Oluwabunmi Olatunji, Victoria Nikitaras, Nicole O. McPherson
{"title":"Unlocking the power of semen analysis in primary health care — a path to men’s health and lifestyle transformation","authors":"Hannah E. Lyons, Andrew Peel, Macarena Gonzalez, Josh Deluao, Oluwabunmi Olatunji, Victoria Nikitaras, Nicole O. McPherson","doi":"10.1038/s41585-025-01047-1","DOIUrl":"10.1038/s41585-025-01047-1","url":null,"abstract":"Declining fertility, overlooked mental health, and reduced life expectancy underscore the urgent need for renewed attention to men’s health. A semen analysis, traditionally used to assess fertility, holds untapped potential as a tool for promoting lifestyle changes and preventing chronic diseases in men. Spermatogenesis is highly sensitive to environmental and lifestyle factors and can be an early indicator of overall health. Disruptions in this process can signal underlying systemic issues and predict long-term health risks, including cardiovascular disease and metabolic disorders. An increasing number of men seek to engage in preconception care, as fertility is closely tied to a man’s sense of masculinity, identity and aspirations for fatherhood. In this context, a semen analysis can be a powerful motivator to encourage healthy behaviours and proactive health management. By incorporating semen analysis into primary care, health care providers can leverage men’s desire for fatherhood as an entry point to discuss broader health concerns, such as mental well-being, nutrition and physical activity. This approach would address immediate reproductive health, and also promote long-term wellness, helping to reduce the burden of chronic disease in men. This Review discusses the association between semen parameters and men’s overall health, describing how these parameters can be influenced by lifestyle and environmental changes. Semen analysis is also presented as a potential tool to motivate men to undertake lifestyle changes to improve their reproductive and overall health.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 10","pages":"687-702"},"PeriodicalIF":14.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial dysfunction as a crucial mediator of ADT-induced cardiovascular risk 线粒体功能障碍是adt诱导心血管风险的重要中介
IF 14.6 1区 医学
Nature Reviews Urology Pub Date : 2025-06-05 DOI: 10.1038/s41585-025-01050-6
Yu-Hsiang Lin, Kuo-Jen Lin, Horng-Heng Juang
{"title":"Mitochondrial dysfunction as a crucial mediator of ADT-induced cardiovascular risk","authors":"Yu-Hsiang Lin, Kuo-Jen Lin, Horng-Heng Juang","doi":"10.1038/s41585-025-01050-6","DOIUrl":"10.1038/s41585-025-01050-6","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 8","pages":"562-563"},"PeriodicalIF":14.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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