Source renewal is essential for mouse TIME models

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-10-14 DOI:10.1038/s41585-024-00960-1

Annette Fenner

引用次数: 0

查看原文本刊更多论文

源头更新对小鼠 TIME 模型至关重要

科学报告》（Scientific Reports）上的一项研究利用等位移植技术研究了小鼠繁殖核对前列腺癌发展和瘤内巨噬细胞群的影响，说明了了解小鼠模型对探索肿瘤免疫微环境（TIME）的重要性。将 TRAMP-C1 细胞植入来自两个繁殖核（nA 和 nB）的 C57BL/6J 小鼠体内，测量肿瘤生长期和瘤内巨噬细胞概况。69天后，54%的nB小鼠出现肿瘤种植，而100%的nA小鼠在28天后出现肿瘤种植。在两组小鼠的TIME中都观察到了明显增加的M2巨噬细胞特征，但它们之间没有明显差异。然而，nB 组肿瘤中的 M1 巨噬细胞数量（11-27%）约为 nA 组（4-15%）的两倍，而且非极化巨噬细胞数量较少；nA 组的 M1:M2 平均比例为 1:8，nB 组为 1:4。同一亚系小鼠的肿瘤进展和巨噬细胞数量不同，这说明了动物来源更新对控制小鼠癌症模型变量的重要性，尤其是在 TIME 研究中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.