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The bladder tumour microbiome and BCG response 膀胱肿瘤微生物群与卡介苗反应
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-06-18 DOI: 10.1038/s41585-024-00910-x
Louise Lloyd
{"title":"The bladder tumour microbiome and BCG response","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00910-x","DOIUrl":"10.1038/s41585-024-00910-x","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 7","pages":"389-389"},"PeriodicalIF":12.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progression-free survival end points in prostate cancer: are we truly making progress 前列腺癌无进展生存期终点：我们是否真正取得了进展
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-06-17 DOI: 10.1038/s41585-024-00902-x
Ravi A. Madan, Edwin M. Posadas, Richard J. Lee
{"title":"Progression-free survival end points in prostate cancer: are we truly making progress","authors":"Ravi A. Madan, Edwin M. Posadas, Richard J. Lee","doi":"10.1038/s41585-024-00902-x","DOIUrl":"10.1038/s41585-024-00902-x","url":null,"abstract":"Recently, several therapeutic strategies in prostate cancer have been granted regulatory approval based on progression-free survival benefits alone, which is a relative change in the therapeutic development of prostate cancer treatments. Previously, overall survival was a requirement for approvals. Whether this approach is warranted or beneficial to patients remains unclear.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 11","pages":"646-648"},"PeriodicalIF":12.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141333766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell penile cancer atlas to identify disease drivers 单细胞阴茎癌图谱确定疾病驱动因素
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-06-14 DOI: 10.1038/s41585-024-00909-4
Maria Chiara Masone
{"title":"Single-cell penile cancer atlas to identify disease drivers","authors":"Maria Chiara Masone","doi":"10.1038/s41585-024-00909-4","DOIUrl":"10.1038/s41585-024-00909-4","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 7","pages":"390-390"},"PeriodicalIF":12.1,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promising efficacy of UTI vaccines as an alternative to antibiotics 尿毒症疫苗替代抗生素的疗效令人期待
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-06-14 DOI: 10.1038/s41585-024-00905-8
Quentin Mak, Julian Greig, Prokar Dasgupta, Sachin Malde, Nicholas Raison
{"title":"Promising efficacy of UTI vaccines as an alternative to antibiotics","authors":"Quentin Mak, Julian Greig, Prokar Dasgupta, Sachin Malde, Nicholas Raison","doi":"10.1038/s41585-024-00905-8","DOIUrl":"10.1038/s41585-024-00905-8","url":null,"abstract":"Antibiotics are the mainstay prophylaxis and treatment for recurrent urinary tract infections (UTIs). However, antibiotic resistance is rising globally, leading to infections that are harder to treat. In view of this resistance, alternative, non-antibiotic treatments for recurrent UTIs are now being developed; among them, UTI vaccines have shown promising results.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 12","pages":"701-702"},"PeriodicalIF":12.1,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new signalling-based system for germ cell reprogramming 基于信号的生殖细胞重编程新系统
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-06-13 DOI: 10.1038/s41585-024-00907-6
Maria Chiara Masone
{"title":"A new signalling-based system for germ cell reprogramming","authors":"Maria Chiara Masone","doi":"10.1038/s41585-024-00907-6","DOIUrl":"10.1038/s41585-024-00907-6","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 7","pages":"390-390"},"PeriodicalIF":12.1,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prompt-based stewardship to reduce extended-spectrum antibiotic treatment in UTI 减少尿毒症扩展谱抗生素治疗的及时监管。
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-06-13 DOI: 10.1038/s41585-024-00908-5
Maria Chiara Masone
{"title":"A prompt-based stewardship to reduce extended-spectrum antibiotic treatment in UTI","authors":"Maria Chiara Masone","doi":"10.1038/s41585-024-00908-5","DOIUrl":"10.1038/s41585-024-00908-5","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 7","pages":"390-390"},"PeriodicalIF":12.1,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engaging medical students in urological academic research 让医科学生参与泌尿外科学术研究。
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-06-11 DOI: 10.1038/s41585-024-00903-w
Kamil Malshy, Taylor Braunagel, Anna Ochsner, Borivoj Golijanin, Elias Hyams
{"title":"Engaging medical students in urological academic research","authors":"Kamil Malshy, Taylor Braunagel, Anna Ochsner, Borivoj Golijanin, Elias Hyams","doi":"10.1038/s41585-024-00903-w","DOIUrl":"10.1038/s41585-024-00903-w","url":null,"abstract":"Medical students provide an unmistakable contribution to clinical research, owing to a diverse skill set, spanning from data collection to analysis and academic writing. Being involved in clinical urology also helps students to clarify career paths and boost competitiveness for residency matches. However, medical students’ involvement encounters challenges, including time constraints and a need for honed research skills. Addressing these hurdles necessitates effective mentorship.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 11","pages":"644-645"},"PeriodicalIF":12.1,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rediscovering citrate as a biomarker for prostate cancer 重新发现作为前列腺癌生物标志物的柠檬酸盐。
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-05-29 DOI: 10.1038/s41585-024-00899-3
Lucas Galey, Ayokunle Olanrewaju, Hermann Nabi, Jean-Sébastien Paquette, Frédéric Pouliot, Étienne Audet-Walsh
{"title":"Rediscovering citrate as a biomarker for prostate cancer","authors":"Lucas Galey, Ayokunle Olanrewaju, Hermann Nabi, Jean-Sébastien Paquette, Frédéric Pouliot, Étienne Audet-Walsh","doi":"10.1038/s41585-024-00899-3","DOIUrl":"10.1038/s41585-024-00899-3","url":null,"abstract":"For many years, PSA has been the most commonly used biomarker for prostate cancer screening and diagnosis. Although serum PSA measurement is highly sensitive, this biomarker has several limitations. Citrate, a molecule closely linked to the unique metabolism of prostate cancer, has the potential to be used as a complementary biomarker alongside PSA.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 10","pages":"573-575"},"PeriodicalIF":12.1,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nocturia and obstructive sleep apnoea 夜尿和阻塞性睡眠呼吸暂停。
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-05-23 DOI: 10.1038/s41585-024-00887-7
Olaf P. J. Vrooman, Philip E. V. van Kerrebroeck, Michael R. van Balken, Gommert A. van Koeveringe, Mohammad S. Rahnama’i
{"title":"Nocturia and obstructive sleep apnoea","authors":"Olaf P. J. Vrooman, Philip E. V. van Kerrebroeck, Michael R. van Balken, Gommert A. van Koeveringe, Mohammad S. Rahnama’i","doi":"10.1038/s41585-024-00887-7","DOIUrl":"10.1038/s41585-024-00887-7","url":null,"abstract":"Nocturia, the need to urinate at night, is a common symptom in patients with obstructive sleep apnoea (OSA). Continuous positive airway pressure treatment can reduce nocturia in some patients, but the underlying mechanisms are complex and not fully understood. OSA affects the autonomic nervous system, oxidative stress and endothelial damage. Furthermore, the commonly held theory attributing polyuria to a false signal of cardiac overload and response natriuresis has limitations. A comprehensive approach to the management of nocturia in OSA, considering factors such as comorbidities, medication use, alcohol consumption and lifestyle, is needed. Effective management of nocturia in OSA requires a multidisciplinary approach, and urologists should be aware of the potential effect of OSA on physiology and refer patients for further testing at a sleep centre. In addition to continuous positive airway pressure, other interventions such as oral appliances and surgical obstruction treatment could be beneficial for some patients. Overall, understanding the complex interplay between OSA and nocturia is crucial for optimizing patient outcomes. In this Review, the authors provide urologists and other interested physicians with an improved understanding of the multifactorial pathophysiology underlying the correlation between obstructive sleep apnoea and nocturia. They describe current evidence, identify topics for future research, and provide practical recommendations for managing patients with this complex condition.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 12","pages":"735-753"},"PeriodicalIF":12.1,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical models of bladder cancer: BBN and beyond 膀胱癌临床前模型：BBN 及其他
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-05-20 DOI: 10.1038/s41585-024-00885-9
David Matye, Juliann Leak, Benjamin L. Woolbright, John A. Taylor III
{"title":"Preclinical models of bladder cancer: BBN and beyond","authors":"David Matye, Juliann Leak, Benjamin L. Woolbright, John A. Taylor III","doi":"10.1038/s41585-024-00885-9","DOIUrl":"10.1038/s41585-024-00885-9","url":null,"abstract":"Preclinical modelling is a crucial component of advancing the understanding of cancer biology and therapeutic development. Several models exist for understanding the pathobiology of bladder cancer and evaluating therapeutics. N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced bladder cancer is a commonly used model that recapitulates many of the features of human disease. Particularly in mice, BBN is a preferred laboratory model owing to a high level of reproducibility, high genetic fidelity to the human condition, and its relative ease of use. However, important aspects of the model are often overlooked in laboratory studies. Moreover, the advent of new models has yielded a variety of methodologies that complement the use of BBN. Toxicokinetics, histopathology, molecular genetics and sex can differ between available models and are important factors to consider in bladder cancer modelling. In this Review, the authors comprehensively assess current models of bladder cancer with an emphasis on the N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced bladder cancer model owing to its high fidelity to the human condition.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 12","pages":"723-734"},"PeriodicalIF":12.1,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141069439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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