Nature Reviews Urology最新文献_第9页

Pathophysiological effects of hypoxia on testis function and spermatogenesis 低氧对睾丸功能和精子发生的病理生理影响

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-06 DOI: 10.1038/s41585-024-00969-6

Tessa Lord

{"title":"Pathophysiological effects of hypoxia on testis function and spermatogenesis","authors":"Tessa Lord","doi":"10.1038/s41585-024-00969-6","DOIUrl":"https://doi.org/10.1038/s41585-024-00969-6","url":null,"abstract":"Multiple conditions can cause hypoxia in the testis, including exposure to high altitude, sleep apnoea, testicular torsion and varicocele. Varicocele accounts for up to 44% of instances of primary infertility, but the cumulative contribution of hypoxic conditions to male infertility is undefined. Results of controlled hypobaric hypoxia studies have demonstrated a substantial detrimental effect of short-term and long-term exposures on sperm; however, downstream effects on embryo development and offspring health are less well understood. Hypoxia can have direct and indirect effects on the molecular biology and biochemistry of germ cells, including changes to gene expression, metabolism, oxidative stress and to the endocrine environment. Hypoxia also has often-overlooked effects on the epididymis, such as altered composition and gene expression of epithelial cells, with knock-on effects on sperm maturation, including the capacity to acrosome react. Evidence from model species shows that paternal hypoxia exposure results in disrupted embryo development and transgenerational effects on male fertility and offspring physiology. Overall, hypoxia induces a complex, multifaceted subfertility phenotype that is reversible with resolution of the exposure, in part because of a resilient testis stem cell population that thrives in hypoxia. However, the potential for transgenerational effects deserves further exploration, particularly in considering the purported decline in sperm counts over the past 50 years.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"42 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic therapy for treating overactive bladder is not supported by clinical evidence 临床证据不支持抗生素治疗膀胱过度活动

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-02 DOI: 10.1038/s41585-024-00974-9

Jelizaveta Pereca, Adrian Wagg, Megan Kennedy, Christopher Chapple

{"title":"Antibiotic therapy for treating overactive bladder is not supported by clinical evidence","authors":"Jelizaveta Pereca, Adrian Wagg, Megan Kennedy, Christopher Chapple","doi":"10.1038/s41585-024-00974-9","DOIUrl":"https://doi.org/10.1038/s41585-024-00974-9","url":null,"abstract":"A number of reports have suggested that the use of prolonged antibiotic treatment could be an effective therapy for patients with overactive bladder (OAB); however, this approach is contrary to existing recommendations regarding the prolonged non-specific use of antibiotics. The existing evidence in this area seems to be circumstantial and anecdotal but, despite this limitation, the use of long-term antibiotic therapy for OAB seems to be increasing. Review and synthesis of the existing evidence for use of antibiotic therapy in patients with OAB identify few studies — just seven papers and four conference proceedings — which are heterogeneous in their design, inclusion and exclusion criteria, treatment regimen employed, approach to the use of antimuscarinic medications, follow-up protocols, and measured outcomes. Overall, the limitation of these published data, the potential adverse events associated with long-term antibiotic use, concerns about antimicrobial resistance and the wide availability of other conventional treatments mean that no compelling data support the routine use of antibiotic therapy and that antibiotic treatment of OAB is not supported by an adequate contemporary evidence base. In the absence of acute urinary tract infection, the management of the non-specific syndrome of OAB should follow existing evidence-based investigational and treatment guidelines. Contemporary therapy following attention to fluid intake relies upon anticholinergic or β3-adrenergic agonist treatment with progression to intravesical onabotulinumtoxinA therapy or neuromodulation in non-responders to oral therapy.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"252 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting surgical outcome for renal tumours 预测肾肿瘤的手术结果

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-12-11 DOI: 10.1038/s41585-024-00987-4

Isobel Leake

引用次数: 0

Neoadjuvant therapy in MIBC MIBC的新辅助治疗

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-12-11 DOI: 10.1038/s41585-024-00989-2

Isobel Leake

引用次数: 0

Diagnosis of ccRCC ccRCC的诊断

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-12-11 DOI: 10.1038/s41585-024-00988-3

Isobel Leake

引用次数: 0

Personalized 3D models for prostate cancer surgery 前列腺癌手术的个性化3D模型

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-12-11 DOI: 10.1038/s41585-024-00986-5

Maria Chiara Masone

引用次数: 0

Virtual reality for nephrolithotomy 虚拟现实用于肾镜取石术

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-12-11 DOI: 10.1038/s41585-024-00990-9

Isobel Leake

引用次数: 0

The mechanism of action of neuromodulation in the treatment of overactive bladder 神经调节治疗膀胱过动症的作用机制

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-12-09 DOI: 10.1038/s41585-024-00967-8

Jan Krhut, Hanne Kobberø, Reine Kanaan, Mikkel Fode, Mads Poulsen, Peter Zvara

{"title":"The mechanism of action of neuromodulation in the treatment of overactive bladder","authors":"Jan Krhut, Hanne Kobberø, Reine Kanaan, Mikkel Fode, Mads Poulsen, Peter Zvara","doi":"10.1038/s41585-024-00967-8","DOIUrl":"https://doi.org/10.1038/s41585-024-00967-8","url":null,"abstract":"Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placebo-controlled studies have confirmed its clinical effect. Many neuromodulation methods using different devices and stimulation parameters, targeting different neural structures have been introduced, but only a limited number have been adopted into routine clinical use. A substantial volume of basic research and clinical studies addressing specific effects of neuromodulation in the treatment of overactive bladder (OAB) have been published to date; however, their mechanistic implications have not been comprehensively summarized. Thus, our understanding of the mechanism of action of neuromodulation in OAB treatment is mainly based on postulated theories. Results from animal experiments suggest that different neuromodulation methods used to treat OAB share the same basic principles. The most likely explanation for the effect of neuromodulation in OAB therapy is the suppression of bladder afferent signalling, promotion of spinal guarding reflexes and modulation of non-specific supraspinal regulatory circuits.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"28 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serial ctDNA to understand PARPi resistance 序列ctDNA了解PARPi抗性

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-12-09 DOI: 10.1038/s41585-024-00984-7

Annette Fenner

引用次数: 0

PFOA affects androgen metabolism 全氟辛酸影响雄激素代谢

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00985-6

Louise Lloyd

引用次数: 0