Nature Reviews Urology最新文献_第9页

Krause corpuscles act as genital vibration detectors 克劳斯体细胞是生殖器振动探测器

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-16 DOI: 10.1038/s41585-024-00922-7

Annette Fenner

引用次数: 0

Increased xenokidney survival 提高异种肾存活率

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-15 DOI: 10.1038/s41585-024-00918-3

Louise Lloyd

引用次数: 0

Alternative promoters activate oncogenic programmes 替代启动子激活致癌程序

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-12 DOI: 10.1038/s41585-024-00919-2

Louise Lloyd

引用次数: 0

Microplastics in the penis 阴茎中的微塑料

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-12 DOI: 10.1038/s41585-024-00917-4

Louise Lloyd

引用次数: 0

Optimizing cystoscopy and TURBT: enhanced imaging and artificial intelligence 优化膀胱镜检查和 TURBT：增强成像和人工智能。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-09 DOI: 10.1038/s41585-024-00904-9

Eugene Shkolyar, Steve R. Zhou, Camella J. Carlson, Shuang Chang, Mark A. Laurie, Lei Xing, Audrey K. Bowden, Joseph C. Liao

{"title":"Optimizing cystoscopy and TURBT: enhanced imaging and artificial intelligence","authors":"Eugene Shkolyar, Steve R. Zhou, Camella J. Carlson, Shuang Chang, Mark A. Laurie, Lei Xing, Audrey K. Bowden, Joseph C. Liao","doi":"10.1038/s41585-024-00904-9","DOIUrl":"10.1038/s41585-024-00904-9","url":null,"abstract":"Diagnostic cystoscopy in combination with transurethral resection of the bladder tumour are the standard for the diagnosis, surgical treatment and surveillance of bladder cancer. The ability to inspect the bladder in its current form stems from a long chain of advances in imaging science and endoscopy. Despite these advances, bladder cancer recurrence and progression rates remain high after endoscopic resection. This stagnation is a result of the heterogeneity of cancer biology as well as limitations in surgical techniques and tools, as incomplete resection and provider-specific differences affect cancer persistence and early recurrence. An unmet clinical need remains for solutions that can improve tumour delineation and resection. Translational advances in enhanced cystoscopy technologies and artificial intelligence offer promising avenues to overcoming the progress plateau. Cystoscopy and transurethral resection of the bladder tumour are crucial in bladder cancer diagnosis, treatment and surveillance. Advances in enhanced cystoscopy technologies and artificial intelligence offer promising avenues to address the unmet need to improve tumour delineation and resection.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"46-54"},"PeriodicalIF":12.1,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer 前列腺癌中 PSMA 表达、调节和异质性的生物学决定因素。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-08 DOI: 10.1038/s41585-024-00900-z

Martin K. Bakht, Himisha Beltran

{"title":"Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer","authors":"Martin K. Bakht, Himisha Beltran","doi":"10.1038/s41585-024-00900-z","DOIUrl":"10.1038/s41585-024-00900-z","url":null,"abstract":"Prostate-specific membrane antigen (PSMA) is an important cell-surface imaging biomarker and therapeutic target in prostate cancer. The PSMA-targeted theranostic 177Lu-PSMA-617 was approved in 2022 for men with PSMA-PET-positive metastatic castration-resistant prostate cancer. However, not all patients respond to PSMA-radioligand therapy, in part owing to the heterogeneity of PSMA expression in the tumour. The PSMA regulatory network is composed of a PSMA transcription complex, an upstream enhancer that loops to the FOLH1 (PSMA) gene promoter, intergenic enhancers and differentially methylated regions. Our understanding of the PSMA regulatory network and the mechanisms underlying PSMA suppression is evolving. Clinically, molecular imaging provides a unique window into PSMA dynamics that occur on therapy and with disease progression, although challenges arise owing to the limited resolution of PET. PSMA regulation and heterogeneity — including intertumoural and inter-patient heterogeneity, temporal changes, lineage dynamics and the tumour microenvironment — affect PSMA theranostics. PSMA response and resistance to radioligand therapy are mediated by a number of potential mechanisms, and complementary biomarkers beyond PSMA are under development. Understanding the biological determinants of cell surface target regulation and heterogeneity can inform precision medicine approaches to PSMA theranostics as well as other emerging therapies. This review explores the basic biology of prostate-specific membrane antigen (PSMA) and its growing significance in molecular imaging and treatment. It emphasizes the importance of understanding PSMA regulation and heterogeneity for the effective application of PSMA-targeted radioligand therapy.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"26-45"},"PeriodicalIF":12.1,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Advances in sliding clip renorrhaphy for partial nephrectomy 作者更正：用于肾部分切除术的滑动夹肾切除术的进展。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-05 DOI: 10.1038/s41585-024-00915-6

David Homewood, Tayla Fay, Nicholas Tan, Andrew Silagy, Niall M. Corcoran, Nathan Lawrentschuk, Dinesh Agarwal

引用次数: 0

CRISPR–Cas9 potential for identifying novel therapeutic targets in muscle-invasive bladder cancer CRISPR-Cas9 在确定肌肉浸润性膀胱癌新治疗靶点方面的潜力。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-07-01 DOI: 10.1038/s41585-024-00901-y

Danielle J. Smith, Sapna Lunj, Antony D. Adamson, Sankari Nagarajan, Tim A. D. Smith, Kimberley J. Reeves, Peter J. Hoskin, Ananya Choudhury

{"title":"CRISPR–Cas9 potential for identifying novel therapeutic targets in muscle-invasive bladder cancer","authors":"Danielle J. Smith, Sapna Lunj, Antony D. Adamson, Sankari Nagarajan, Tim A. D. Smith, Kimberley J. Reeves, Peter J. Hoskin, Ananya Choudhury","doi":"10.1038/s41585-024-00901-y","DOIUrl":"10.1038/s41585-024-00901-y","url":null,"abstract":"Gene editing technologies help identify the genetic perturbations driving tumour initiation, growth, metastasis and resistance to therapeutics. This wealth of information highlights tumour complexity and is driving cancer research towards precision medicine approaches based on an individual’s tumour genetics. Bladder cancer is the 11th most common cancer in the UK, with high rates of relapse and low survival rates in patients with muscle-invasive bladder cancer (MIBC). MIBC is highly heterogeneous and encompasses multiple molecular subtypes, each with different responses to therapeutics. This evidence highlights the need to identify innovative therapeutic targets to address the challenges posed by this heterogeneity. CRISPR–Cas9 technologies have been used to advance our understanding of MIBC and determine novel drug targets through the identification of drug resistance mechanisms, targetable cell-cycle regulators, and novel tumour suppressor and oncogenes. However, the use of these technologies in the clinic remains a substantial challenge and will require careful consideration of dosage, safety and ethics. CRISPR–Cas9 offers considerable potential for revolutionizing bladder cancer therapies, but substantial research is required for validation before these technologies can be used in the clinical setting. In this Perspective, the authors provide an overview of current research using CRISPR–Cas gene editing technologies to understand biological mechanisms and identify novel therapeutic targets in muscle-invasive bladder cancer. Future perspectives about the use of CRISPR-based therapeutics in the clinic, as well as current limitations and ethical considerations, are also discussed.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"55-65"},"PeriodicalIF":12.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De-clear cell differentiated renal cell carcinoma — a new therapeutic target 去透明细胞分化型肾细胞癌--新的治疗目标

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-06-27 DOI: 10.1038/s41585-024-00911-w

Keith A. Lawson, W. Marston Linehan

引用次数: 0

Advances in sliding clip renorrhaphy for partial nephrectomy 用于肾部分切除术的滑动夹式肾切除术的进展。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-06-25 DOI: 10.1038/s41585-024-00906-7

David Homewood, Tayla Fay, Nicholas Tan, Andrew Silagy, Niall M. Corcoran, Nathan Lawrentschuk, Dinesh Agarwal

引用次数: 0